Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.HN.11 2.47457502
2G.S1.02 5.14714535
3G.S1.04 4.05571437
4G.S1.05 6.47679419
5G.H1.01 5.40464439
6G.H1.08 5.865438
7G.S2.06 8.02107439
8G.S2.08 7.44071435
9G.S3.01 6.0375434
10G.S3.03 8.00143537
11G.S3.04 6.91514516
12G.S3.05 3.92057537
13G.S3.06 7.25024615
14G.s3h2.03 4.61607419
15G.H2.03 6.37357419
16G.H2.04 4.0525409
17G.H2.06 5.81224719
18G.H2.07 5.81102719
19G.h2s4.01 7.296519
20G.S4.02 4.58286518
21G.S4.04 6.31536479
22G.s4h3.04 6.671435168
23G.s4h3.05 6.410364169
24G.s4h3.14 1.55393406
25G.H3.01 4.91457509
26G.H3.03 3.874294134
27G.H3.06 4.75857406
28G.H3.09 6.81612779
29G.H3.17 8.045615
30G.H3.18 5.17171519
31G.S5.03 3.51607438
32G.S5.04 4.58943579
33G.S5.07 4.42286439
34G.HG.04 7.491794169
35G.HG.07 4.161794169
36G.HG.15 4.03171507
37G.hgh4.02 6.881435137
38G.hgh4.05 6.4925407
39G.H4.03 6.12114504
40G.H4.05 2.810714224
41G.H4.10 7.177145136
42G.H4.15 6.45179478
43G.h4s6.02 5.31478
44G.S6.02 9.09893407
45G.s6h5.01 6.73536439
46G.H5.03 7.28643438
47G.H5.06 8.86321433
48G.H5.08 6.85143438
49G.H5.09 3.88393434
50G.H5.13 9.1625408
51G.H5.26 8.13357405
52b.1x1 2.1575404
53b.1x7 2.96643408
54b.1x16 2.57404
55b.1x19 5.01571406
56b.h2x1 4.84405
57b.b1x4 4.06514597
58b.l1x3 7.57694769
59b.b2x1 10.3903518
60b.b2x5 7.23514567
61b.b3x3 4.97714458
62b.l3x2 4.97971569
63b.b4x3 5.84714457
64b.b4x4 9.425468
65b.b4x5 4.60714457
66b.b4x6 10.3076669
67b.b5x2 4.795715217
68b.b5x3 6.7402769
69b.b5x5 6.11572455
70b.b5x7 6.78821407
71b.l5x1 5.04321458
72b.l5x2 4.27786456
73b.l5x5 9.18976619
74b.b6x5 4.22911856
75b.b7x1 7.005404
76b.b8x3 5.03321406
77b.b8x4 6.16429556
78b.l8x1 4.30214455
79b.l8x5 2.71714403
80b.b9x3 5.53929456
81b.l9x3 8.386295109
82b.l9x6 5.35921918
83b.b10x3 4.08929408
84b.b10x5 4.54452609
85b.b11x2 4.38429407
86b.b11x4 6.592864109
87b.l11x2 7.866074109
88b.b12x3 3.96357488
89b.b12x6 8.205517108
90b.b13x7 8.06657587
91b.l13x3 7.45689
92b.l13x6 7.18893419
93b.b14x3 5.79464485
94b.b15x1 6.59612789
95b.b15x2 7.06857446
96b.l15x1 4.732517
97b.b16x4 10.945486
98b.b16x5 5.49393405
99b.b16x6 8.91857688
100b.b17x5 7.66357447
101b.b17x7 8.95321448
102b.l17x3 7.92694749
103b.l17x6 7.49393419
104b.b18x3 4.34107448
105b.b18x5 5.19821405
106b.l18x1 6.785246116
107b.l18x2 5.708214117
108b.b19x2 8.18743546
109b.b19x4 6.74821448
110b.l19x2 6.43486549
111b.b20x2 6.08393446
112b.b20x4 11.0766548
113b.b20x6 6.74796746
114b.b21x1 9.96643447
115b.b21x2 3.52607406
116b.b21x5 5.7025404
117b.b21x7 7.68914505
118b.l21x2 4.98321404
119b.b22x5 5.588336117
120b.l22x5 6.69196179
121b.b23x1 4.00929405
122b.b23x6 7.560246197
123b.b24x6 6.740714198
124b.l24x3 3.2875405
125b.b25x3 6.27754195
126b.l25x3 9.525715159
127b.l25x6 12.6832418
128b.l27x1 11.8435719
129b.l27x2 7.126434159
130b.b28x3 5.06571407
131b.b28x4 9.290364156
132b.b28x6 8.619145159
133b.b28x7 5.71607499
134g.h1x3 1.30714403
135g.h1x5 1.96929406
136g.h2x11 9.895714116
137g.ctx3 7.69409
138g.ctx6 3.832506
139g.ctx14 5.90464499
140g.ctx15 7.84214499
141g.ctx16 5.12937998
142NT 8.61905925
1431x42 3.00971506
1442x40 7.265145148
1452x42 5.21357408
1462x46 4.476434129
1472x51 3.67407
1482x57 5.76071626
1492x61 5.66857526
1502x64 8.07036423
1512x65 6.93679424
152E1 4.66309624
1533x36 4.30452626
1543x44 3.19321406
1553x49 6.69679409
1563x50 8.158214129
157I2x53 7.31743507
1584x46 4.288574248
1594x50 5.00254249
160E2 13.02792025
1615x39 6.24629527
1625x43 7.47238625
1635x50 3.19464407
1645x51 4.70343527
1655x58 6.080716129
166I3 3.92679833
1676x48 6.09514528
168E3 5.25643421
1697x34 7.26321424
1707x52 3.40393409
1717x53 5.367147129
1728x49 4.820364146
173Lig 8.981211320
174H.HA.19 0.5821434200
175H.HC.03 0.2845715200
176H.HC.07 0.4685714200
177H.HD.07 0.655400
178H.hdhe.01 0.522619600
179H.HE.05 0.499714500
180H.HE.06 0.613214400
181H.HF.06 0.849643400
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1G.HN.43 b.b5x3 16.05957.47714NoYes099
2G.HN.39 G.HN.43 16.26653.93857NoNo059
3G.HN.39 b.b5x5 16.37064.03143NoYes055
4b.b4x5 b.b5x5 15.80737.57571YesYes575
5b.b4x5 b.b6x5 16.00113.28286YesYes576
6b.b2x4 b.b6x5 29.21253.27NoYes066
7b.b10x4 b.b2x4 29.310312.4143NoNo066
8b.b10x2 b.b10x4 24.85914.57429NoNo066
9b.b10x2 b.b14x3 34.28563.85286NoYes065
10b.b11x5 b.b14x3 43.06037.08143NoYes065
11b.b10x1 b.b11x5 58.52264.42429NoNo096
12b.b10x1 b.l9x6 58.59443.27NoYes098
13G.H2.07 b.l9x6 74.11466.34YesYes198
14G.H2.04 G.H2.07 74.95164.28571YesYes099
15G.H2.04 G.H3.08 86.7673.81714YesNo099
16G.H3.08 G.S4.04 86.80815.74286NoYes099
17G.S4.04 G.S5.04 82.2643.47714YesYes799
18G.S5.04 G.S5.06 1004.74429YesNo098
19G.S5.06 G.s4h3.01 51.47387.31429NoNo087
20G.HG.04 G.s4h3.01 51.025813.2229YesNo097
21G.H4.03 G.HG.04 51.19333.68571YesYes049
22G.H4.03 G.H4.04 98.9615.29YesNo044
23G.H4.04 I3 98.84052.32571NoYes343
24G.H5.06 I3 43.84926.41286YesYes333
25G.H5.06 G.S5.03 40.46333.41YesYes338
26G.H5.10 G.S5.03 40.66454.17571NoYes068
27G.H5.10 G.S6.02 40.54115.72NoYes067
28G.S6.02 G.h4s6.12 19.931815.8714YesNo074
29G.H5.17 G.h4s6.12 19.78743.85714NoNo054
306x29 G.H5.17 39.60543.24429NoNo055
316x29 G.H5.26 38.04543.33571NoYes055
32G.H5.20 G.H5.26 36.17268.52714NoYes095
33G.H5.20 G.H5.25 34.94514.15143NoNo097
343x50 G.H5.25 34.330814.0557YesNo097
35G.S5.06 G.S6.05 48.54757.48428NoNo084
36G.H4.07 G.S6.05 48.7763.96143NoNo054
37G.H4.03 G.H4.07 48.7414.57571YesNo045
38G.H5.13 G.S6.02 20.149410.8343YesYes087
39G.H5.13 G.H5.17 20.14910.4686YesNo085
40G.H5.05 I3 54.46065.3NoYes353
41G.H5.05 G.S2.08 54.45354.51429NoYes355
42G.H5.08 G.S2.08 51.1486.73714YesYes385
43G.H5.08 G.S3.01 50.67565.91571YesYes384
44G.H2.04 G.H2.08 19.74143.4YesNo098
45G.S3.01 I2x51 50.02856.18714YesNo047
46G.H2.06 b.l9x6 18.03593.58YesYes198
47G.H2.08 G.H3.15 19.48133.23571NoNo188
48G.H3.15 G.H3.17 36.59374.84286NoYes185
49G.S4.02 G.S5.02 19.81953.78429YesNo086
50G.H3.17 b.l25x6 34.07825.14286YesYes158
51b.l22x5 g.ctx6 16.19574.68429YesYes096
52b.l22x5 b.l24x2 17.84329.71714YesNo1796
53b.h2x5 b.l24x2 18.18216.94857NoNo056
54b.h2x1 b.h2x5 18.37063.79143YesNo055
55b.b21x5 b.h2x1 18.83917.47143YesYes045
56b.b21x5 b.b21x7 20.53110.4343YesYes045
57b.b21x7 b.b24x6 29.56110.1986YesYes058
58b.b23x6 b.b24x6 29.82038.40571YesYes1978
59b.b23x6 b.l23x2 32.28234.10714YesNo078
60b.l21x7 b.l23x2 33.28538.00143NoNo058
61b.l21x7 b.l23x1 33.67176.44857NoNo056
62b.l23x1 b.l25x6 34.064617.5271NoYes068
63G.H5.15 I2x51 49.86143.31143NoNo077
64G.H5.15 G.H5.19 49.72053.84571NoNo078
65G.H5.19 I2x53 49.579613.1243NoYes087
663x49 I2x53 42.59289.85286YesYes097
67b.lhb1x11 g.ctx5 10.3495.04857NoNo049
68b.l22x1 g.ctx5 10.66653.86NoNo099
69b.b25x7 b.lhb1x11 12.70815.45NoNo074
70b.b25x7 b.b28x6 11.296314.8071NoYes079
71b.b4x6 b.b5x3 10.588211.4343YesYes699
72b.b10x2 b.b6x2 13.6862.65571NoNo068
73b.b10x3 b.b6x2 13.54735.31143YesNo088
74b.b12x5 b.b13x4 21.0733.36714NoNo064
75b.b12x7 b.b13x4 20.83322.68714NoNo094
76b.b11x5 b.l13x7 15.51314.84857NoNo069
77b.b13x5 b.b13x7 19.65796.48571NoYes047
78b.b12x7 b.l12x3 20.11317.43429NoNo095
79b.l17x5 b.l19x1 16.82164.20571NoNo069
80b.l17x5 b.l19x2 16.55874.20714NoYes069
81b.l17x3 b.l19x2 14.30324.32YesYes499
822x42 3x49 42.03134.77714YesYes089
832x42 4x46 39.68783.61YesYes088
844x46 4x50 38.26734.33429YesYes2489
853x38 4x50 37.99147.77857NoYes079
863x38 4x53 37.83183.18714NoNo078
873x37 4x53 37.67363.68NoNo068
883x37 5x43 37.51866.06286NoYes065
89E2 NT 10.318217.0929YesYes255
905x43 Lig 19.414513.4014YesYes250
916x48 7x45 13.45736.29571YesNo089
927x45 7x49 16.3718.75857NoNo099
932x46 7x49 22.11073.53143YesNo099
942x46 7x53 22.25733.85143YesYes1299
953x50 7x53 24.56178.23143YesYes1299
96b.b13x2 b.l12x3 19.87282.22571NoNo045
97H.hdhe.01 b.b13x2 19.62740.321429YesNo004
98H.hdhe.01 H.hdhe.03 17.99180.334286YesNo000
99H.HD.07 H.hdhe.03 17.52450.348571YesNo000
100G.H3.09 G.S5.02 19.84775.74YesNo096
101G.H3.09 G.S5.04 18.89115.57YesYes799
102G.H3.18 G.S4.02 17.44458.07286YesYes198
103G.H3.15 G.H3.18 17.31363.79714NoYes189
104b.b14x3 b.b15x1 11.81537.13571YesYes859
105b.b12x5 b.b13x5 19.42465.68429NoNo064
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
NTNT9.92YesYes5522
2x64NT9.327142YesYes3512
E2NT17.09292YesYes5512
2x65NT6.291432YesYes4522
7x31NT7.177142NoYes2522
1x392x613.362NoYes6621
1x397x394.141432NoNo6522
2x533x363.367140NoYes8621
2x572x615.968572YesYes6611
2x573x324.492862YesNo6511
2x573x364.134292YesYes6611
2x577x384.717142YesNo6511
2x577x425.394292YesNo6612
2x57Lig9.857142YesYes6010
2x603x286.120NoNo4512
2x60Lig3.931430NoYes4010
2x612x6512.12142YesYes6412
2x617x393.375712YesNo6512
2x61Lig3.517142YesYes6010
2x643x253.674292YesNo3912
2x64Lig11.20142YesYes3010
3x22E28.064292NoYes3521
3x253x296.078572NoNo9421
3x25E28.864292NoYes9521
3x26E23.375712NoYes5521
3x29Lig6.411432NoYes4010
3x32Lig3.615712NoYes5010
3x334x574.582NoNo4712
3x335x435.022862NoYes4511
3x33Lig10.92142NoYes4010
3x366x486.587142YesYes6812
3x367x416.384292YesNo6712
3x36Lig3.655712YesYes6010
3x375x436.062860NoYes6521
4x605x3911.32430NoYes5721
E2E243.862YesYes5511
5x36E218.68430NoYes4521
5x38E27.930NoYes4521
5x37E25.842NoYes4521
5x40E25.794290NoYes5521
6x58E29.378570NoYes3521
7x31E25.267142NoYes2521
E2E311.132YesYes5112
7x34E213.90572YesYes4511
6x55E24.515712NoYes6521
E2Lig33.24862YesYes5010
5x39E29.142YesYes7511
5x395x435.234292YesYes7511
5x435x4711.29142YesNo5712
5x436x553.821432YesNo5612
5x43Lig13.40142YesYes5010
6x487x416.905712YesNo8722
6x547x345.954290NoYes4421
7x34Lig6.411432YesYes4010
7x38Lig6.992NoYes5010
2x642x658.078572YesYes3412
3x29E25.372NoYes4511
4x59E24.230NoYes5521
5x39Lig3.592862YesYes7010
6x517x342.781430NoYes6421
5x395x421.942YesNo7512
3x363x391.698572YesNo6912
4x63E21.005710NoYes4521

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
92.86Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
92.86Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
92.31Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
92.31Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
86.67Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
85.71Single5XR8AM8415XR8-CB1-AM841
84.62Single7V3ZCP559407V3Z-CB1-CP55940
81.25Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
80.00Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
78.57Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
76.92Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
76.92Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
75.00Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
73.33Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
73.33Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
73.33Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
73.33Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
70.59Single5ZTYAM102575ZTY-CB2-AM10257
70.59Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
70.59Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
66.67Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
66.67Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
66.67Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
66.67Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
64.71Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
64.71Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
64.29Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
62.50Single5XRAAM115425XRA-CB1-AM11542
62.50Single7FEECP559407FEE-CB1-CP55940-ZCZ011
62.50Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
60.00Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
58.82Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
58.82Single6KQICP559406KQI-CB1-CP55940-Org27569
58.82Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
58.82Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
55.56Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
53.33Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
52.38Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
50.00Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
50.00Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
50.00Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
50.00Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
50.00Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
50.00Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
50.00Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
50.00Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
50.00Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
50.00Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
50.00Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
47.83Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
47.37Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
47.06Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
47.06Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
47.06Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
47.06Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
47.06Single8JXSPF-61428JXS-D1-PF-6142
46.67Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
45.45Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
45.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
45.00Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
45.00Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
45.00Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
44.44Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
44.44Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
44.44Single8E0GBU728E0G-μ-BU72
44.44Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
44.44Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
43.75Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
43.75Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
43.75Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
43.75Single8K5CAcipimox8K5C-HCA2-Acipimox
43.75Consensushca_onOrthosteric Ligandhca2_on
43.48Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
42.86Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
42.86Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
42.86Consensuslpl_onOrthosteric Ligands1p_on lpa_on
42.86Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
42.11Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
42.11Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
42.11Single7YITNalfurafine7YIT-κ-Nalfurafine
42.11Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
42.11Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
42.11Consensuslpl_offOrthosteric Ligands1p_off lpa_off
42.11Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
42.11Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
42.11Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
41.67Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
41.67Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
41.67Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
41.67Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
41.18Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
41.18Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
41.18Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
41.18Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
41.18Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
41.18Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
41.18Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
41.18Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
41.18Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
41.18Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
41.18Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
41.18Consensushca_on_gpOrthosteric Ligandhca2_on_gp
41.18Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
40.91Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
40.91Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
40.91Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
40.00Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
40.00Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
40.00Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
40.00Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
40.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
40.00Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
40.00Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
40.00Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
40.00Single8K5BNiacin8K5B-HCA2-Niacin
40.00Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
40.00Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
40.00Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
40.00Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
40.00Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
40.00Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
39.13Single6W25SHU91196W25-MC4-SHU9119-Ca
39.13Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
39.13Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
39.13Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
39.13Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
39.13Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
38.89Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
38.89Single5C1MBU725C1M-μ-BU72
38.89Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
38.89Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
38.89Single7C4SS1P7C4S-S1P3-S1P
38.89Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
38.89Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
38.89Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
38.89Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
38.89Single8TF5Oleic acid8TF5-GPR6-Oleic acid
38.89Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
38.89Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
38.89Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
38.89Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
38.89Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
38.46Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
38.46Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
38.46Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
38.46Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
38.46Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
38.10Single4UG2CGS216804UG2-A2A-CGS21680
38.10Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
38.10Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
38.10Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
38.10Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
38.10Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
38.10Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
38.10Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
37.50Single6AKXA4R6AKX-CCR5-A4R
37.50Single6AKYMaraviroc6AKY-CCR5-Maraviroc
37.50Single6B73MP11046B73-κ-MP1104
37.50Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
37.50Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
37.50Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
37.50Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
37.50Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
37.50Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
37.50Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
37.50Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
37.50Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
37.50Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
37.50Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
37.50Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
37.50Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
37.50Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
37.50Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
37.50Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
37.50Consensusorexin_offOrthosteric Ligandox2_off ox1_off
37.50Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
37.50Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
37.50Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
37.50Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
37.50Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
36.84Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
36.84Single4DJHJDTic4DJH-κ-JDTic
36.84Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
36.84Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
36.84Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
36.84Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
36.84Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
36.84Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
36.84Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
36.84Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
36.84Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
36.84Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
36.84Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
36.84Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
36.84Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
36.84Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
36.84Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
36.84Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
36.84Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
36.84Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
36.84Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
36.84Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
36.84Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
36.84Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
36.84Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
36.84Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
36.84Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
36.84Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
36.84Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
36.36Single4XT1Fractalkine4XT1-US28-Fractalkine
36.36Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
36.36Single7QA8Peptide7QA8-STE2-Peptide
36.36Single7QA8Peptide7QA8-STE2-Peptide
36.36Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
36.36Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
36.36Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
36.36Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
36.36Single8KIGSHU91198KIG-MC3-SHU9119-Ca
36.36Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
36.36Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
36.36Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
36.00Single8ZRTET-18ZRT-ETB-ET-1
36.00Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
36.00Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
35.29Single4MBSMaraviroc4MBS-CCR5-Maraviroc
35.29Single4ZJCSB-6740424ZJC-OX1-SB-674042
35.29Single6TPGEMPA6TPG-OX2-EMPA
35.29Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
35.29Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
35.29Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
35.29Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
35.29Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
35.29Single8IHKAcifran8IHK-HCA3-Acifran
35.29Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
35.29Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
35.29Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
35.29Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
35.29Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
35.29Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.29Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
35.29Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
35.29Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
35.00Single4RWADIPP-NH24RWA-δ-DIPP-NH2
35.00Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
35.00Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
35.00Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
35.00Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
35.00Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
35.00Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
35.00Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
35.00Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
35.00Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
35.00Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
35.00Single8XYIVUF106618XYI-CXCR3-VUF10661
35.00Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
35.00Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
35.00Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
35.00Consensusalpha1_offOrthosteric Ligandalpha1a_off
35.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
35.00Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
35.00Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
35.00Consensuslpa_offOrthosteric Ligandlpa1_off
35.00Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
35.00Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
35.00Consensusorexin_onOrthosteric Ligandox2_on
35.00Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
34.78Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
34.78Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
34.78Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
34.78Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
34.78Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
34.78Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
34.78Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
34.78Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
34.78Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
34.78Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
34.78Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
34.78Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
34.78Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
34.78Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
34.62Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
34.62Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
34.48Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
34.48Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
34.38Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
34.38Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
33.33Single2Y04Salbutamol2Y04-β1-Salbutamol
33.33Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
33.33Single3OE6IT1t3OE6-CXCR4-IT1t
33.33Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
33.33Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
33.33Single4YAYZD-71554YAY-AT1-ZD-7155
33.33Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
33.33Single5X93K-87945X93-ETB-K-8794
33.33Single6DRXLisuride6DRX-5-HT2B-Lisuride
33.33Single6TOTLemborexant6TOT-OX1-Lemborexant
33.33Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
33.33Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
33.33Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
33.33Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
33.33Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
33.33Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
33.33Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
33.33Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
33.33Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
33.33Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
33.33Single7UL4Alvimopan7UL4-μ-Alvimopan
33.33Single7UM4AS26747237UM4-5-HT5A-AS2674723
33.33Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
33.33Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
33.33Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
33.33Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
33.33Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
33.33Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
33.33Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
33.33Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
33.33Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
33.33Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
33.33Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
33.33Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
33.33Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
33.33Single7YXAONO-54306087YXA-S1P5-ONO-5430608
33.33Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
33.33Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
33.33Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
33.33Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
33.33Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
33.33Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
33.33Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
33.33Single8JXRLSD8JXR-D1-LSD
33.33Single8K5DGSK2560738K5D-HCA2-GSK256073
33.33Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
33.33Single8T1WCVN4248T1W-GPR6-CVN424
33.33Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
33.33Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
33.33Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
33.33Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
33.33Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
33.33Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
33.33Single9CHXS-Carazolol9CHX-β2-S-Carazolol
33.33Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
33.33Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
33.33Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
33.33Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
33.33Consensus5ht2_onOrthosteric Ligand5ht2b_on
33.33Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
33.33Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
33.33Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
33.33Consensusangiotensin_onOrthosteric Ligandat1_on
33.33Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
33.33Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
33.33Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
33.33Consensusblt_onOrthosteric Ligandblt1_on
33.33Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
33.33Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
33.33Consensusendothelin_offOrthosteric Ligandetb_off
33.33Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
33.33Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
33.33Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
33.33Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
33.33Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
33.33Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
33.33Consensusleukotriene_onOrthosteric Ligandblt_on
33.33Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
33.33Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
33.33Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
33.33Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
33.33Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
33.33Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
33.33Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
33.33Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
33.33Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
32.26Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
32.14Single6IGLIRL16206IGL-ETB-IRL1620
32.14Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
32.14Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
32.14Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
32.14Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
32.14Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
32.00Single6JODAngiotensin II6JOD-AT2-Angiotensin II
32.00Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
32.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
32.00Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
32.00Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
32.00Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
32.00Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
32.00Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
32.00Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
32.00Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
32.00Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
32.00Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
32.00Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
32.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
32.00Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
32.00Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
31.82Single3NY9ICI118-5513NY9-β2-ICI118-551
31.82Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
31.82Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
31.82Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
31.82Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
31.82Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
31.82Single7SK9CCX6627SK9-ACKR3-CCX662
31.82Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
31.82Single8QJ2pN1628QJ2-MC4-pN162-Gs
31.82Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
31.82Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
31.58Single2Y03Isoprenaline2Y03-β1-Isoprenaline
31.58Single2YCWS-Carazolol2YCW-β1-S-Carazolol
31.58Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
31.58Single5D6LS-Carazolol5D6L-β2-S-Carazolol
31.58Single5TVNLSD5TVN-5-HT2B-LSD
31.58Single5WQCEMPA5WQC-OX2-EMPA
31.58Single5XPRBosentan5XPR-ETB-Bosentan
31.58Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
31.58Single6TP6Filorexant6TP6-OX1-Filorexant
31.58Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
31.58Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
31.58Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
31.58Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
31.58Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
31.58Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
31.58Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
31.58Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.58Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
31.58Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
31.58Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
31.58Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
31.58Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
31.58Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
31.58Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
31.58Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
31.58Single8S4DCMF-0198S4D-Apelin-CMF-019
31.58Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.58Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
31.58Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
31.58Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
31.58Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
31.58Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
31.58Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
31.58Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
31.58Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
31.58Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
31.58Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
31.58Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
31.58Consensustrace-amine_onOrthosteric Ligandta1_on
31.25Single3OE9IT1t3OE9-CXCR4-IT1t
31.25Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
31.25Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
31.25Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
31.25Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
31.25Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
31.25Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
31.25Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
31.25Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
31.25Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
31.25Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
31.25Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
31.25Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
31.03Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
31.03Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
31.03Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
31.03Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
31.03Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
31.03Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
30.77Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
30.77Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
30.77Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
30.77Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
30.77Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
30.77Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
30.77Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
30.77Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
30.77Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
30.77Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
30.77Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
30.43Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
30.43Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
30.43Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
30.43Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
30.43Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
30.43Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
30.43Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
30.43Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
30.43Single8WDTphotoNECA8WDT-A2A-photoNECA
30.43Single8WKYPG-9348WKY-MC4-PG-934
30.43Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
30.43Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
30.43Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
30.43Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
30.43Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
30.00Single2YDVNECA2YDV-A2A-NECA
30.00Single3P0GBI1671073P0G-β2-BI167107
30.00Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
30.00Single4UHRCGS216804UHR-A2A-CGS21680
30.00Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
30.00Single5D5AS-Carazolol5D5A-β2-S-Carazolol
30.00Single5D5BS-Carazolol5D5B-β2-S-Carazolol
30.00Single5G53NECA5G53-A2A-NECA-Gs
30.00Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
30.00Single6H7JIsoprenaline6H7J-β1-Isoprenaline
30.00Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
30.00Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
30.00Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
30.00Single6TQ7SB-3348676TQ7-OX1-SB-334867
30.00Single7B6WCyclazosin7B6W-α1b-Cyclazosin
30.00Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
30.00Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
30.00Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
30.00Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
30.00Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
30.00Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
30.00Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
30.00Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
30.00Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
30.00Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
30.00Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
30.00Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
30.00Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
30.00Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
30.00Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
30.00Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
30.00Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
30.00Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
30.00Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
30.00Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
30.00Consensusa2_onOrthosteric Liganda2b_on
30.00Consensusa2_on_gpOrthosteric Liganda2b_on_gp
30.00Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
30.00Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
30.00Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
30.00Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
30.00Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
30.00Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
30.00Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
30.00Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
30.00Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
30.00Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
30.00Consensuslpa_onOrthosteric Ligandlpa1_on
30.00Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
30.00Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
30.00Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
30.00Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.00Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
29.63Single4XT3Fractalkine4XT3-US28-Fractalkine
29.63Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
29.63Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
29.63Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
29.63Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
29.63Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
29.63Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
29.63Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
29.63Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
29.63Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
29.41Single3ODUIT1t3ODU-CXCR4-IT1t
29.41Single5WS3EMPA5WS3-OX2-EMPA
29.41Single5ZKQABT-4915ZKQ-PAF-ABT-491
29.41Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
29.41Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
29.41Single6TODEMPA6TOD-OX1-EMPA-Na
29.41Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
29.41Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
29.41Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.41Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
29.41Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
29.41Single7XRRLemborexant7XRR-OX2-Lemborexant
29.41Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
29.41Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
29.41Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.41Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
29.41Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
29.41Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
29.41Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
29.41Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
29.41Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
29.41Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
29.41Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
29.41Single8Y0HVUF114188Y0H-CXCR3-VUF11418
29.41Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
29.41Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
29.41Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.41Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
29.41Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
29.41Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
29.41Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
29.17Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
29.17Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
29.17Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
29.17Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
29.17Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
29.17Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
29.17Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
29.17Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
29.17Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
29.17Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
29.17Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
29.03Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
28.95Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
28.57Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
28.57Single3D4STimolol3D4S-β2-Timolol
28.57Single4LDEBI1671074LDE-β2-BI167107
28.57Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
28.57Single4PY02MeSATP4PY0-P2Y12-2MeSATP
28.57Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
28.57Single6A93Risperidone6A93-5-HT2A-Risperidone
28.57Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
28.57Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
28.57Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
28.57Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
28.57Single6MXTSalmeterol6MXT-β2-Salmeterol
28.57Single6ZG4HTL00099366ZG4-M1-HTL0009936
28.57Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
28.57Single7DFPSpiperone7DFP-D2-Spiperone
28.57Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
28.57Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
28.57Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
28.57Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
28.57Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
28.57Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
28.57Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
28.57Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
28.57Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
28.57Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
28.57Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
28.57Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
28.57Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
28.57Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
28.57Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
28.57Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
28.57Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
28.57Single8JJ8Formoterol8JJ8-β2-Formoterol
28.57Single8JJLOlodaterol8JJL-β2-Olodaterol
28.57Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
28.57Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
28.57Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
28.57Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
28.57Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
28.57Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
28.57Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
28.57Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
28.57Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
28.57Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
28.57Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
28.12Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
28.12Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
28.00Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
28.00Single6PT2KGCHM076PT2-δ-KGCHM07
28.00Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
28.00Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
28.00Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
28.00Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
28.00Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
28.00Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
28.00Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
28.00Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
28.00Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
28.00Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
28.00Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
28.00Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
27.78Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
27.78Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
27.78Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
27.78Single6PS0S-Carazolol6PS0-β2-S-Carazolol
27.78Single6PS4ICI118-5516PS4-β2-ICI118-551
27.78Single6PS5S-Propranolol6PS5-β2-S-Propranolol
27.78Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
27.78Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
27.78Single6TPNHTL66416TPN-OX2-HTL6641
27.78Single6VI4JDTic6VI4-κ-JDTic
27.78Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
27.78Single6ZG9GSK10347026ZG9-M1-GSK1034702
27.78Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
27.78Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
27.78Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
27.78Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
27.78Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
27.78Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
27.78Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
27.78Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.78Single7UL3Famotidine7UL3-H2-Famotidine
27.78Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
27.78Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
27.78Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.78Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
27.78Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
27.78Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
27.78Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
27.78Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
27.78Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
27.78Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
27.78Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
27.78Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
27.78Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
27.78Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
27.78Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
27.78Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
27.78Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
27.78Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
27.78Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
27.78Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.78Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.78Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.78Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
27.78Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
27.78Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
27.78Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
27.78Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
27.78Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
27.78Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
27.78Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
27.78Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
27.78Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
27.78Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
27.78Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
27.78Consensusalpha1_onOrthosteric Ligandalpha1a_on
27.78Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
27.78Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
27.78Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
27.78Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
27.78Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
27.78Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
27.78Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
27.78Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
27.59Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
27.59Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
27.59Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
27.59Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
27.59Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
27.59Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
27.27Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
27.27Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
27.27Single6K1QIRL25006K1Q-ETB-IRL2500
27.27Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
27.27Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
27.27Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
27.27Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
27.27Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
27.27Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
27.27Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
27.27Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.27Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
27.27Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
27.27Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
27.27Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
27.27Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
27.27Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
27.27Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single8XVJMacitentan8XVJ-ETA-Macitentan
27.27Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
27.27Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
27.27Consensuscck_onOrthosteric Ligandccka_on cckb_on
27.27Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
27.27Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
27.27Consensusprostanoid_offOrthosteric Ligandep_off dp_off
27.27Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
27.27Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
27.27Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
26.92Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
26.92Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
26.92Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
26.92Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
26.92Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.92Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
26.92Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
26.92Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
26.92Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
26.92Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
26.92Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
26.92Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
26.67Single3OE8IT1t3OE8-CXCR4-IT1t
26.67Single5GLHEndothelin-15GLH-ETB-Endothelin-1
26.67Single6IGKEndothelin-36IGK-ETB-Endothelin-3
26.67Single6TQ9SB-4081246TQ9-OX1-SB-408124
26.67Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.67Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
26.67Single9CHUNoradrenaline9CHU-β2-Noradrenaline
26.67Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
26.67Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
26.67Consensusbombesin_onOrthosteric Ligandbb2_on
26.67Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
26.67Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
26.67Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
26.67Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
26.67Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
26.32Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
26.32Single3NY8ICI118-5513NY8-β2-ICI118-551
26.32Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
26.32Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
26.32Single4EJ4Naltrindole4EJ4-δ-Naltrindole
26.32Single4GBRS-Carazolol4GBR-β2-S-Carazolol
26.32Single4QKX35V4QKX-β2-35V
26.32Single5DHGC-355DHG-NOP-C-35
26.32Single5DHHSB-6121115DHH-NOP-SB-612111
26.32Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
26.32Single5TGZAM65385TGZ-CB1-AM6538
26.32Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
26.32Single6GPSMK08126GPS-CCR2-MK0812
26.32Single6H7MSalbutamol6H7M-β1-Salbutamol
26.32Single6IIVDaltroban6IIV-TP-Daltroban
26.32Single6PS1Timolol6PS1-β2-Timolol
26.32Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
26.32Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
26.32Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
26.32Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
26.32Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
26.32Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
26.32Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
26.32Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
26.32Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
26.32Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
26.32Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
26.32Single7WC7Lisuride7WC7-5-HT2A-Lisuride
26.32Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
26.32Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
26.32Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
26.32Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
26.32Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
26.32Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
26.32Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
26.32Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
26.32Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
26.32Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
26.32Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
26.32Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
26.32Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
26.32Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
26.32Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
26.32Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
26.32Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
26.32Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
26.32Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
26.32Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
26.32Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
26.32Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.32Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
26.32Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
26.32Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
26.32Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
26.32Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
26.32Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
26.32Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
26.32Consensus5ht5_onOrthosteric Ligand5ht5a_on
26.32Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
26.32Consensusa3_onOrthosteric Liganda3a_on
26.32Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
26.32Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
26.32Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
26.32Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
26.32Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
26.32Consensusdopamine_offOrthosteric Ligandd2_off d3_off
26.32Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
26.32Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
26.32Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
26.32Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
26.32Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
26.32Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
26.09Single5EE7MK08935EE7-Glucagon-MK0893
26.09Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
26.09Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
26.09Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
26.09Single6PT3DPI-2876PT3-δ-DPI-287
26.09Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.09Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
26.09Single7XN9L-054,5227XN9-SST2-L-054,522
26.09Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
26.09Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
26.09Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
26.09Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Single8X5YAstemizole8X5Y-H1-Astemizole
26.09Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
26.09Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
26.09Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
26.09Consensuskisspeptin_onOrthosteric Ligandkiss1_on
25.93Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
25.93Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
25.93Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
25.93Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
25.93Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
25.93Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
25.93Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
25.93Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
25.93Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
25.93Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
25.93Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
25.81Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
25.00Single2RH1S-Carazolol2RH1-β2-S-Carazolol
25.00Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
25.00Single4IARErgotamine4IAR-5-HT1B-Ergotamine
25.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
25.00Single5JQHS-Carazolol5JQH-β2-S-Carazolol
25.00Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
25.00Single5WIUNemonapride5WIU-D4-Nemonapride
25.00Single5WIVNemonapride5WIV-D4-Nemonapride-Na
25.00Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
25.00Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
25.00Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
25.00Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
25.00Single6D26Fevipiprant6D26-DP2-Fevipiprant
25.00Single6E67BI1671076E67-β2-BI167107-Gs (fused)
25.00Single6FJ3PTH6FJ3-PTH1-PTH
25.00Single6GPXMK08126GPX-CCR2-MK0812
25.00Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
25.00Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
25.00Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
25.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
25.00Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
25.00Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
25.00Single6PS6Timolol6PS6-β2-Timolol
25.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
25.00Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
25.00Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
25.00Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
25.00Single7C61Ergotamine7C61-5-HT1B-Ergotamine
25.00Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
25.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
25.00Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
25.00Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
25.00Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
25.00Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
25.00Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
25.00Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
25.00Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
25.00Single7W41PD1762527W41-BB2-PD176252
25.00Single7WC6LSD7WC6-5-HT2A-LSD
25.00Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
25.00Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
25.00Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
25.00Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
25.00Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
25.00Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
25.00Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
25.00Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
25.00Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
25.00Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
25.00Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
25.00Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
25.00Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
25.00Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
25.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
25.00Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
25.00Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
25.00Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
25.00Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
25.00Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
25.00Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
25.00Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
25.00Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
25.00Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
25.00Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
25.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
25.00Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
25.00Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
25.00Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
25.00Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
25.00Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
25.00Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
25.00Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
25.00Consensusa3_on_gpOrthosteric Liganda3a_on_gp
25.00Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
25.00Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
25.00Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
25.00Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
25.00Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
25.00Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
25.00Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
25.00Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
25.00Consensusamine_offonOrthosteric Ligandamine_off amine_on
25.00Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
25.00Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
25.00Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
25.00Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
25.00Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
25.00Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
25.00Consensusblt_offOrthosteric Ligandblt1_off
25.00Consensusbombesin_offOrthosteric Ligandbb2_off
25.00Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
25.00Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
25.00Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
25.00Consensusdp_offOrthosteric Liganddp2_off
25.00Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
25.00Consensusep_offOrthosteric Ligandep4_off
25.00Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
25.00Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
25.00Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
25.00Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
25.00Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
25.00Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
25.00Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
25.00Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
25.00Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
25.00Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
25.00Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
25.00Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
25.00Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
25.00Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
25.00Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
25.00Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
24.14Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
24.14Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
24.14Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
24.14Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
24.14Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
24.14Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
24.14Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
24.14Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
24.00Single3QAKUK-4320973QAK-A2A-UK-432097
24.00Single6HLOAprepitant6HLO-NK1-Aprepitant
24.00Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
24.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
24.00Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
24.00Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
24.00Single7XNACYN1548067XNA-SST2-CYN154806
24.00Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
24.00Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
24.00Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
24.00Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
24.00Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
24.00Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
24.00Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
24.00Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
23.81Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
23.81Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
23.81Single4U15Tiotropium4U15-M3-Tiotropium
23.81Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
23.81Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
23.81Single6J21Aprepitant6J21-NK1-Aprepitant
23.81Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
23.81Single6OL9Tiotropium6OL9-M5-Tiotropium
23.81Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
23.81Single6WGTLSD6WGT-5-HT2A-LSD
23.81Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
23.81Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
23.81Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
23.81Single7TUYGSK682753A7TUY-GPR183-GSK682753A
23.81Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
23.81Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
23.81Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
23.81Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.81Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
23.81Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
23.81Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
23.81Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
23.81Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
23.81Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
23.81Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
23.81Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
23.81Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
23.81Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
23.81Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
23.81Single8XVLZibotentan8XVL-ETA-Zibotentan
23.81Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
23.81Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
23.81Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
23.81Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
23.81Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
23.81Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
23.81Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
23.81Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
23.81Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
23.81Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
23.81Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
23.81Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
23.81Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
23.81Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
23.81Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
23.81Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
23.81Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
23.81Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
23.81Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
23.53Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
23.53Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
23.53Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
23.53Single7SRQLSD7SRQ-5-HT2B-LSD
23.53Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
23.53Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
23.53Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
23.53Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
23.53Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
23.53Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.53Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
23.53Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
23.53Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
23.53Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
23.53Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
23.53Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.53Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
23.53Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
23.53Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
23.53Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
23.53Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
23.53Single9B9Y7DY9B9Y-CB1-7DY
23.53Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
23.53Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
23.53Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
23.33Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
23.33Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
23.33Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
23.33Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
23.33Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
23.33Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
23.33Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
23.33Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
23.33Consensusbradykinin_onOrthosteric Ligandbk2_on
23.33Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
23.33Consensusendothelin_onOrthosteric Ligandetb_on eta_on
23.33Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
23.08Single3OE0CVX153OE0-CXCR4-CVX15
23.08Single5WF5UK-4320975WF5-A2A-UK-432097
23.08Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
23.08Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
23.08Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
23.08Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
23.08Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
23.08Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
23.08Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
23.08Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
23.08Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
23.08Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
23.08Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
23.08Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
22.73Single4AMIBucindolol4AMI-β1-Bucindolol
22.73Single5CXVTiotropium5CXV-M1-Tiotropium
22.73Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
22.73Single5X33BIIL2605X33-BLT1-BIIL260
22.73Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
22.73Single6CM4Risperidone6CM4-D2-Risperidone
22.73Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
22.73Single6IIURamatroban6IIU-TP-Ramatroban
22.73Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
22.73Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
22.73Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
22.73Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
22.73Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
22.73Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
22.73Single7K15MKD0467K15-BLT1-MKD046-Na
22.73Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
22.73Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
22.73Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.73Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
22.73Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
22.73Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
22.73Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
22.73Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single8JWY2-1188JWY-A2A-2-118
22.73Single8JWZAB9288JWZ-A2A-AB928-Na
22.73Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
22.73Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
22.73Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
22.73Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
22.73Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
22.73Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
22.73Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
22.73Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
22.73Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
22.73Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
22.73Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
22.73Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
22.73Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
22.73Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
22.73Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
22.73Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
22.73Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
22.73Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
22.73Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
22.58Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
22.58Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
22.58Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
22.22Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
22.22Single3PWHZM-2413853PWH-A2A-ZM-241385
22.22Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
22.22Single4S0VSuvorexant4S0V-OX2-Suvorexant
22.22Single5U09Taranabant5U09-CB1-Taranabant
22.22Single6DS0Ly2660976DS0-5-HT2B-Ly266097
22.22Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
22.22Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
22.22Single6ME2Ramelteon6ME2-MT1-Ramelteon
22.22Single6ME9Ramelteon6ME9-MT2-Ramelteon
22.22Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
22.22Single6TPJSuvorexant6TPJ-OX2-Suvorexant
22.22Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
22.22Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
22.22Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
22.22Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
22.22Single7F8YDevazepide7F8Y-CCKA-Devazepide
22.22Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
22.22Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
22.22Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
22.22Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
22.22Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
22.22Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
22.22Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
22.22Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
22.22Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
22.22Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
22.22Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
22.22Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
22.22Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
22.22Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
22.22Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
22.22Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
22.22Single8GNGIstradefylline8GNG-A2A-Istradefylline
22.22Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
22.22Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
22.22Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
22.22Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
22.22Single8IWESpermidine8IWE-TA9-Spermidine
22.22Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
22.22Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
22.22Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
22.22Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
22.22Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.22Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.22Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
22.22Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
22.22Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
22.22Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
22.22Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
22.22Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
22.22Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
22.22Single9BA0A1AKN9BA0-CB1-A1AKN
22.22Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
22.22Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
22.22Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
22.22Consensusalpha2_offOrthosteric Ligandalpha2c_off
22.22Consensusangiotensin_offOrthosteric Ligandat1_off
22.22Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
22.22Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
22.22Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
22.22Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
22.22Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
22.22Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
22.22Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
22.22Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
22.22Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
22.22Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
22.22Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
22.22Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
22.22Consensusvasop-oxy_onOrthosteric Ligandv2_on
22.22Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
21.88Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
21.88Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
21.88Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
21.88Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
21.74Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
21.74Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
21.74Single6H7LDobutamine6H7L-β1-Dobutamine
21.74Single6IBLArformoterol6IBL-β1-Arformoterol
21.74Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
21.74Single7EZCUKA7EZC-A2A-UKA
21.74Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
21.74Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
21.74Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
21.74Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
21.74Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
21.74Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
21.74Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
21.74Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
21.74Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
21.74Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
21.74Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
21.74Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
21.74Consensuschemerin_onOrthosteric Ligandcml1_on
21.74Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
21.43Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
21.43Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
21.43Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
21.43Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
21.43Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
21.43Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
21.43Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
21.43Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
21.21Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
21.21Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
21.05Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
21.05Single2YDOAdenosine2YDO-A2A-Adenosine
21.05Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
21.05Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
21.05Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
21.05Single6A94Zotepine6A94-5-HT2A-Zotepine
21.05Single6IQLL7458706IQL-D4-L745870
21.05Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
21.05Single6KUXRS-799486KUX-α2a-RS-79948
21.05Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
21.05Single6TP3Nemorexant6TP3-OX1-Nemorexant
21.05Single6V9SGTPL114036V9S-OX1-GTPL11403
21.05Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
21.05Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
21.05Single7AROLUF58337ARO-A2A-LUF5833-Na
21.05Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
21.05Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
21.05Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
21.05Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
21.05Single7T32ZM-2413857T32-A2A-ZM-241385
21.05Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
21.05Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
21.05Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
21.05Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
21.05Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
21.05Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
21.05Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
21.05Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
21.05Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
21.05Single8K2WAMG4878K2W-CXCR3-AMG487
21.05Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.05Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
21.05Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
21.05Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
21.05Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
21.05Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
21.05Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
21.05Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
21.05Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.05Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
21.05Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
21.05Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
21.05Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
21.05Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
21.05Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
21.05Single9BJKNaloxone9BJK-μ-Naloxone-NAM
21.05Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
21.05Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
21.05Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
21.05Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
21.05Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
21.05Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
20.83Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
20.83Single5WF6UK-4320975WF6-A2A-UK-432097
20.83Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
20.83Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
20.83Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
20.83Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
20.83Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
20.83Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
20.83Single8IEIA1LYA8IEI-GPR156-A1LYA
20.83Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
20.83Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
20.83Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
20.83Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
20.83Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
20.83Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
20.83Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
20.83Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
20.83Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
20.69Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
20.69Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
20.69Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
20.69Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
20.69Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
20.69Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
20.69Single7SK3CXCL127SK3-ACKR3-CXCL12
20.69Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
20.69Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
20.69Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
20.59Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
20.00Single2Y01Dobutamine2Y01-β1-Dobutamine
20.00Single2Y02Carmoterol2Y02-β1-Carmoterol
20.00Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
20.00Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
20.00Single4DAJTiotropium4DAJ-M3-Tiotropium
20.00Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
20.00Single4MQSIperoxo4MQS-M2-Iperoxo
20.00Single4U14Tiotropium4U14-M3-Tiotropium
20.00Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
20.00Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
20.00Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
20.00Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
20.00Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
20.00Single5UENDU1725UEN-A1-DU172
20.00Single5UIGCmpd-15UIG-A2A-Cmpd-1
20.00Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
20.00Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
20.00Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
20.00Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
20.00Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
20.00Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
20.00Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
20.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
20.00Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
20.00Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
20.00Single7BU7BI1671077BU7-β1-BI167107
20.00Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
20.00Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
20.00Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
20.00Single7F8XNN90567F8X-CCKA-NN9056
20.00Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
20.00Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
20.00Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
20.00Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
20.00Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
20.00Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
20.00Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
20.00Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
20.00Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
20.00Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
20.00Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
20.00Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
20.00Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
20.00Single8CU6LJ-45178CU6-A2A-LJ-4517
20.00Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
20.00Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
20.00Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
20.00Single8IEBA1LYA8IEB-GPR156-A1LYA
20.00Single8IEIA1LYA8IEI-GPR156-A1LYA
20.00Single8IEPA1LYA8IEP-GPR156-A1LYA
20.00Single8IEPA1LYA8IEP-GPR156-A1LYA
20.00Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
20.00Single8JJOAlprenolol8JJO-β2-Alprenolol
20.00Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
20.00Single8RLNLUF58348RLN-A2A-LUF5834
20.00Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
20.00Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
20.00Single8X63Mepyramine8X63-H1-Mepyramine
20.00Single8X64Desloratadine8X64-H1-Desloratadine
20.00Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
20.00Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
20.00Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
20.00Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
20.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
20.00Single9B9ZA1AKO9B9Z-CB1-A1AKO
20.00Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
20.00Single9IYAONO-97105319IYA-GPR55-ONO-9710531
20.00Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
20.00Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
20.00Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
20.00Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
20.00Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
20.00Consensusalpha2_onOrthosteric Ligandalpha2b_on
20.00Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
20.00Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
20.00Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
20.00Consensuscck_offOrthosteric Ligandccka_off
20.00Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
20.00Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
20.00Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
20.00Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
20.00Consensushistamine_offOrthosteric Ligandh1_off
20.00Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
20.00Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
20.00Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
20.00Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
20.00Consensussomatostatin_offOrthosteric Ligandsst2_off
19.35Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
19.35Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
19.35Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
19.35Single8IY6Endothelin-18IY6-ETB-Endothelin-1
19.35Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
19.23Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
19.23Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
19.23Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
19.23Single8IEBA1LYA8IEB-GPR156-A1LYA
19.23Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
19.23Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
19.05Single2Y00Dobutamine2Y00-β1-Dobutamine
19.05Single4NTJAZD12834NTJ-P2Y12-AZD1283
19.05Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
19.05Single5N2RPSB-365N2R-A2A-PSB-36-Na
19.05Single5N2SPSB365N2S-A1-PSB36
19.05Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
19.05Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
19.05Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
19.05Single6HLPNetupitant6HLP-NK1-Netupitant
19.05Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
19.05Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
19.05Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.05Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.05Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
19.05Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
19.05Single8QOTNanobody-E8QOT-μ-Nanobody-E
19.05Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
19.05Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
19.05Single8ZMFA1L108ZMF-5-HT2C-A1L10
19.05Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
19.05Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
19.05Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
19.05Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
19.05Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
19.05Consensusadenosine_offOrthosteric Liganda1_off a2_off
19.05Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
19.05Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
19.05Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
19.05Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.05Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.75Single8A2OTheophylline8A2O-A2A-Theophylline-Na
18.75Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
18.75Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
18.75Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
18.52Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.52Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
18.52Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
18.52Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
18.18Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
18.18Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
18.18Single4BV0Neurotensin4BV0-NTS1-Neurotensin
18.18Single5TZRMK86665TZR-FFA1-MK8666
18.18Single5V54Methiothepin5V54-5-HT1B-Methiothepin
18.18Single6E59L-7607356E59-NK1-L-760735
18.18Single6J20Aprepitant6J20-NK1-Aprepitant
18.18Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
18.18Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
18.18Single6OS1TRV0266OS1-AT1-TRV026
18.18Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
18.18Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
18.18Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
18.18Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
18.18Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
18.18Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
18.18Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
18.18Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
18.18Single8EA0Iperoxo8EA0-M3-Iperoxo
18.18Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
18.18Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
18.18Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
18.18Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
18.18Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
18.18Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
18.18Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
18.18Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
18.18Single9BJKNAM9BJK-μ-Naloxone-NAM
18.18Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
18.18Consensus5ht1_offOrthosteric Ligand5ht1b_off
18.18Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
18.18Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
18.18Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
18.18Consensusneurotensin_onOrthosteric Ligandnts1_on
18.18Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
18.18Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
17.86Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
17.86Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
17.86Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
17.86Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
17.86Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
17.86Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
17.65Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
17.65Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
17.65Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
17.65Single6ME5Agomelatine6ME5-MT1-Agomelatine
17.65Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
17.65Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
17.65Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.65Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.65Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
17.65Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
17.65Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
17.65Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
17.65Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
17.65Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
17.65Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
17.65Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
17.65Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
17.39Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
17.39Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
17.39Single4N4WSANT-14N4W-SMO-SANT-1
17.39Single4XEENeurotensin4XEE-NTS1-Neurotensin
17.39Single4XESNeurotensin4XES-NTS1-Neurotensin
17.39Single6OS2TRV0266OS2-AT1-TRV026
17.39Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
17.39Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
17.39Single6YVRNTS8-136YVR-NTS1-NTS8-13
17.39Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
17.39Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
17.39Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
17.39Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
17.39Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
17.39Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
17.39Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
17.39Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
17.39Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
17.39Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
17.39Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
17.39Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
17.39Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
17.39Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
17.24Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
17.24Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
17.24Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.14Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
17.14Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
16.67Single3PBLEticlopride3PBL-D3-Eticlopride
16.67Single4BUONeurotensin4BUO-NTS1-Neurotensin
16.67Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
16.67Single5L7IVismodegib5L7I-SMO-Vismodegib
16.67Single6HLLCP999946HLL-NK1-CP99994
16.67Single6LI0C176LI0-GPR52-C17
16.67Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
16.67Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
16.67Single6TP4ACT-4622066TP4-OX1-ACT-462206
16.67Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
16.67Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
16.67Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
16.67Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
16.67Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
16.67Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
16.67Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
16.67Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
16.67Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
16.67Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
16.67Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
16.67Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
16.67Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
16.67Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
16.67Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
16.67Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
16.67Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
16.67Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
16.67Consensusgq_nucleotideOrthosteric Ligandgq_p2y
16.67Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
16.67Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
16.13Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
16.00Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
16.00Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
16.00Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
15.79Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
15.79Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
15.79Single4BWBNeurotensin4BWB-NTS1-Neurotensin
15.79Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
15.79Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
15.79Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
15.79Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
15.79Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
15.79Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
15.79Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
15.79Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
15.79Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
15.79Single7BR3Elagolix7BR3-GnRH1-Elagolix
15.79Single7F8ULintitript7F8U-CCKA-Lintitript
15.79Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
15.79Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
15.79Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
15.79Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
15.79Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
15.79Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
15.79Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
15.79Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.79Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
15.79Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
15.79Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
15.79Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
15.79Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
15.79Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
15.79Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.79Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.79Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
15.79Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
15.79Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
15.79Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
15.79Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
15.79Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
15.79Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
15.79Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
15.79Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
15.79Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
15.62Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
15.62Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
15.38Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
15.38Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
15.38Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
15.38Single8XWNCXCL88XWN-CXCR2-CXCL8
15.38Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
15.15Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
15.00Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
15.00Single3REYXAC3REY-A2A-XAC
15.00Single3RZECidoxepin3RZE-H1-Cidoxepin
15.00Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
15.00Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
15.00Single5IU7Q274563465IU7-A2A-Q27456346-Na
15.00Single5IUBQ274563445IUB-A2A-Q27456344-Na
15.00Single5JTBZM-2413855JTB-A2A-ZM-241385
15.00Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
15.00Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
15.00Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
15.00Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
15.00Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
15.00Single6AQFZM-2413856AQF-A2A-ZM-241385
15.00Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
15.00Single6MH8ZM-2413856MH8-A2A-ZM-241385
15.00Single6TPKRetosiban6TPK-OT-Retosiban
15.00Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
15.00Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
15.00Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
15.00Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
15.00Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
15.00Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
15.00Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
15.00Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
15.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
15.00Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
15.00Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
15.00Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
15.00Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
15.00Consensusa2_offOrthosteric Liganda2a_off
15.00Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
15.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
15.00Consensusgrh_offOrthosteric Ligandgnrh1_off
15.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
15.00Consensusopsins_offOrthosteric Ligandrhodopsin_off
15.00Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
15.00Consensussensory_offOrthosteric Ligandopsins_off
15.00Consensusvasop-oxy_offOrthosteric Ligandot_off
14.81Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
14.81Single7SK5CXCL127SK5-ACKR3-CXCL12
14.81Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
14.71Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
14.29Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
14.29Single3EMLZM-2413853EML-A2A-ZM-241385
14.29Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
14.29Single4QIMANTA XV4QIM-SMO-ANTA XV
14.29Single5DSGTiotropium5DSG-M4-Tiotropium
14.29Single5IU8Q274563475IU8-A2A-Q27456347-Na
14.29Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
14.29Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
14.29Single5T04Neurotensin5T04-NTS1-Neurotensin
14.29Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
14.29Single6D27CAY104716D27-DP2-CAY10471
14.29Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
14.29Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
14.29Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
14.29Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
14.29Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
14.29Single6S0LZM-2413856S0L-A2A-ZM-241385
14.29Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
14.29Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
14.29Single7F83PF-051904577F83-Ghrelin-PF-05190457
14.29Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
14.29Single7PYRPSB-21157PYR-A2A-PSB-2115
14.29Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
14.29Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
14.29Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
14.29Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
14.29Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
14.29Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
14.29Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
14.29Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
14.29Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
14.29Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
13.89Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
13.89Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
13.79Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
13.79Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
13.64Single4JKVTaladegib4JKV-SMO-Taladegib
13.64Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
13.64Single5CGCHTL142425CGC-mGlu5-HTL14242
13.64Single5IUAQ274563485IUA-A2A-Q27456348-Na
13.64Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
13.64Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
13.64Single6LUQHaloperidol6LUQ-D2-Haloperidol
13.64Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
13.64Single6S0QZM-2413856S0Q-A2A-ZM-241385
13.64Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
13.64Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
13.64Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
13.64Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
13.64Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
13.64Single7SINNPS-21437SIN-CaS-NPS-2143
13.64Single7SINNPS-21437SIN-CaS-NPS-2143
13.64Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
13.64Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.64Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
13.64Single8GNEKW-63568GNE-A2A-KW-6356-Na
13.64Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
13.64Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
13.64Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
13.33Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
13.33Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
13.33Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
13.04Single5V56TC1145V56-SMO-TC114
13.04Single5V57TC1145V57-SMO-TC114
13.04Single7F1TMIP-1a7F1T-CCR5-MIP-1a
13.04Single7PX4PSB-21137PX4-A2A-PSB-2113
13.04Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
13.04Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
13.04Consensustachykinin_offOrthosteric Ligandnk1_off
12.50Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
12.50Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
12.50Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
12.50Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
12.50Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
12.50Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
12.50Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
12.50Single7WC4Serotonin7WC4-5-HT2A-Serotonin
12.50Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
12.50Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8PWNTheophylline8PWN-A2A-Theophylline
12.50Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
12.20Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
12.12Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
12.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
12.00Single5CGDHTL142425CGD-mGlu5-HTL14242
12.00Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
12.00Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
12.00Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
12.00Single8XVUCXCL28XVU-CXCR2-CXCL2
12.00Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
11.76Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
11.76Single3RFMCaffeine3RFM-A2A-Caffeine
11.76Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
11.76Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
11.76Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
11.76Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
11.76Consensusp2y_offOrthosteric Ligandp2y1_off
11.76Consensussensory_onOrthosteric Ligandopsins_on
11.54Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
11.54Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
11.54Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
11.11Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
11.11Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
11.11Single4XNWMRS25004XNW-P2Y1-MRS2500
11.11Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
11.11Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
11.11Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
11.11Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
11.11Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
11.11Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
11.11Single7WC5Psilocin7WC5-5-HT2A-Psilocin
11.11Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
11.11Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
11.11Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
11.11Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
11.11Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
11.11Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
11.11Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
11.11Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
11.11Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
11.11Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
11.11Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
10.71Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
10.53Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
10.53Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
10.53Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
10.53Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
10.53Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
10.53Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
10.53Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
10.53Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
10.53Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
10.53Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
10.53Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
10.53Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
10.53Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
10.53Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
10.53Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
10.00Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
10.00Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
10.00Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
10.00Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
10.00Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
10.00Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
10.00Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
10.00Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
10.00Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
10.00Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
10.00Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
10.00Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
10.00Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
10.00Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
9.68Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
9.52Single5UVIZM-2413855UVI-A2A-ZM-241385
9.52Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
9.52Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
9.52Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
9.52Single6ZINSR486926ZIN-NTS1-SR48692
9.52Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.52Single7VODCariprazine7VOD-5-HT2A-Cariprazine
9.52Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
9.09Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
9.09Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
9.09Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
9.09Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
8.70Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
8.70Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
8.70Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
8.70Single6Z4SSR486926Z4S-NTS1-SR48692
8.70Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
8.70Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
8.70Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
8.70Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
8.70Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
8.70Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
8.70Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
8.70Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
8.70Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
8.33Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
8.33Single7P2L4YI7P2L-mGlu5-4YI
8.33Single7R0CAVP7R0C-V2-AVP-Arrestin2
8.33Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
8.33Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
8.33Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
8.33Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
8.33Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
8.33Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
8.33Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
8.33Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
8.00Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
8.00Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
8.00Single8XQJJN2418XQJ-Apelin-JN241
8.00Single8XWACXCL18XWA-CXCR2-CXCL1
8.00Single8XWMCXCL68XWM-CXCR2-CXCL6
8.00Single8XWSCXCL58XWS-CXCR2-CXCL5
8.00Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
7.69Single8XWFCXCL38XWF-CXCR2-CXCL3
7.69Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
7.41Single6KNMJN241-96KNM-Apelin-JN241-9
7.41Single8XQJJN2418XQJ-Apelin-JN241
6.90Single7SHEPI; PE7SHE-GPR158-PI; PE
6.67Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
6.25Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
6.25Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
6.25Single5MZPCaffeine5MZP-A2A-Caffeine-Na
6.25Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
5.88Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
5.56Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
5.56Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
5.56Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
5.56Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
5.26Single3UZAGTPL92363UZA-A2A-GTPL9236
5.26Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
5.26Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
5.26Single7V6A-7V6A-M4-PubChem 9864275-Gi1/β1/γ2
5.26Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.26Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
5.26Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.26Consensusgi_sensoryOrthosteric Ligandgi_opsins
5.26Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.26Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.00Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
5.00Single4O9RCyclopamine4O9R-SMO-Cyclopamine
5.00Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
5.00Single7UL2SR486927UL2-NTS1-SR48692-Na
5.00Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
5.00Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
5.00Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
5.00Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
5.00Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
5.00Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
5.00Consensusneurotensin_offOrthosteric Ligandnts1_off
5.00Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
4.76Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
4.76Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
4.76Single4QINSAG1.54QIN-SMO-SAG1.5
4.76Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
4.76Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
4.76Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
4.76Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
4.76Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
4.55Single6FFIMMPEP6FFI-mGlu5-MMPEP
4.55Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
4.55Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
4.55Single7VV6C48/807VV6-MRGPRX2-C48/80
4.55Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
4.55Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single8IYXYL-3658IYX-GPR34-YL-365
4.35Single6FFHFenobam6FFH-mGlu5-Fenobam
4.35Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
4.17Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
4.17Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
4.17Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
4.17Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
4.00Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
3.85Single7SHEPI; PE7SHE-GPR158-PI; PE
3.85Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
3.70Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.33Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7

Consensus Members
Id Members
8GUR 8GUR-CB2-CP55,940-Gi1/β1/γ2
8GUS 8GUS-CB2-HU-308-Gi1/β1/γ2
8GUT 8GUT-CB2-LEI-102-Gi1/β1/γ2
8GUQ 8GUQ-CB2-Olorinab-Gi1/β1/γ2
6KPF 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2
6PT0 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2
6KPG 6KPG-CB1-AM841-Gi1/β1/γ2
Net Summary
Imin 3.16143
Number of Linked Nodes 995
Number of Links 1193
Number of Hubs 181
Number of Links mediated by Hubs 694
Number of Communities 24
Number of Nodes involved in Communities 244
Number of Links involved in Communities 359
Path Summary
Number Of Nodes in MetaPath 106
Number Of Links MetaPath 105
Number of Shortest Paths 2374318
Length Of Smallest Path 3
Average Path Length 34.9659
Length of Longest Path 62
Minimum Path Strength 0.192857
Average Path Strength 5.73903
Maximum Path Strength 25.9664
Minimum Path Correlation 0.701429
Average Path Correlation 0.979289
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.69492
Average % Of Corr. Nodes 34.0407
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 50.1959
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
gi_lipidgi_cannabinoid
gi_ffa
gi_leukotriene
gi_lpa
gi_s1p



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download gi_cannabinoid.zip



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