Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:I26 4.23754199
2A:A:L30 3.18754196
3A:A:L41 5.32754126
4A:A:L44 8.232519
5A:A:L45 5.59754138
6A:A:L46 4.73167618
7A:A:K53 7.3054139
8A:A:E209 12.0775419
9A:A:F219 6.486676128
10A:A:H220 14.9725417
11A:A:M221 3.46254138
12A:A:F222 13.242517
13A:A:D223 5.5254139
14A:A:R232 7.3425418
15A:A:K233 7.402519
16A:A:W234 8.386519
17A:A:I235 4.2675419
18A:A:C237 3.645418
19A:A:F238 8.84333619
20A:A:I244 4.932518
21A:A:I245 3.62254137
22A:A:F246 6.158519
23A:A:V247 4.01407
24A:A:D249 7.6954178
25A:A:Y253 9.405408
26A:A:L270 5.65516
27A:A:F273 8.9975419
28A:A:I276 5.545418
29A:A:W277 10.6416
30A:A:W281 8.78714715
31A:A:L282 5.97419
32A:A:I288 5.29409
33A:A:L289 6.795419
34A:A:F290 5.5725409
35A:A:F312 5.192518
36A:A:F315 8.02167616
37A:A:Y318 5.494516
38A:A:T325 5.64412
39A:A:V334 3.93404
40A:A:T335 3.835414
41A:A:K338 6.292515
42A:A:Y339 4.8425413
43A:A:F340 9.616517
44A:A:F345 8.6175418
45A:A:C359 5.615415
46A:A:Y360 8.218336148
47A:A:H362 8.1054149
48A:A:F363 11.0025415
49A:A:C365 5.12408
50A:A:F376 5.2845128
51A:A:L388 4.4985208
52A:A:Y391 7.52584
53B:B:L14 2.4575408
54B:B:R22 4.93406
55B:B:L30 4.966535
56B:B:V40 4.76167633
57B:B:I43 5.975433
58B:B:H54 9.926549
59B:B:I58 5.074549
60B:B:Y59 6.85667618
61B:B:M61 4.332546
62B:B:W63 7.414547
63B:B:S72 4.858549
64B:B:D76 6.93449
65B:B:L79 5.8375497
66B:B:I81 4.836597
67B:B:W82 11.132509
68B:B:S84 3.7725445
69B:B:Y85 12.845444
70B:B:N88 5.58407
71B:B:K89 7.2785199
72B:B:I93 4.648507
73B:B:L95 5.45498
74B:B:W99 8.79714719
75B:B:M101 4.306519
76B:B:Y105 6.18167696
77B:B:N110 8.21754114
78B:B:Y111 7.725114
79B:B:V112 5.505498
80B:B:C114 4.1825498
81B:B:L117 4.9925419
82B:B:I123 3.8954116
83B:B:Y124 4.8696
84B:B:L126 5.3025495
85B:B:H142 6.94667619
86B:B:Y145 5.82667618
87B:B:C149 3.475418
88B:B:F151 6.098509
89B:B:Q156 6.2425405
90B:B:V158 5.412565
91B:B:T159 5.524519
92B:B:S161 7.57419
93B:B:D163 7.788519
94B:B:C166 4.076568
95B:B:L168 4.06566
96B:B:W169 10.6383618
97B:B:I171 3.5454116
98B:B:Q176 6.8025414
99B:B:F180 8.618567
100B:B:H183 6.66969
101B:B:V187 4.748569
102B:B:M188 5.495418
103B:B:L192 3.9775465
104B:B:F199 8.18569
105B:B:V200 8.17456
106B:B:S201 5.2625469
107B:B:C204 7.08417
108B:B:D205 6.308569
109B:B:K209 12.605466
110B:B:L210 6.9475455
111B:B:W211 9.915668
112B:B:Q220 8.5925457
113B:B:F222 7.45333658
114B:B:H225 9.78571759
115B:B:I229 7.2525457
116B:B:I232 5.4825458
117B:B:F234 6.4175405
118B:B:F235 8.415636
119B:B:P236 8.8675437
120B:B:F241 8.692556
121B:B:T243 6.43458
122B:B:D247 7.832559
123B:B:R251 9.17333658
124B:B:F253 6.13667656
125B:B:D254 5.0325439
126B:B:L255 6.27456
127B:B:D258 8.202557
128B:B:Q259 3.5985216
129B:B:M262 5.7225434
130B:B:Y264 8.10333635
131B:B:H266 9.2275434
132B:B:I269 5.454534
133B:B:F278 5.65637
134B:B:R283 6.716539
135B:B:L284 5.4275435
136B:B:L285 4.825406
137B:B:Y289 7.79857737
138B:B:N295 8.04667636
139B:B:V296 6.215435
140B:B:W297 9.3675438
141B:B:D298 9.674539
142B:B:L300 5.51436
143B:B:K301 8.0375435
144B:B:R304 9.9535
145B:B:H311 9.146676109
146B:B:R314 13.246518
147B:B:V315 4.7754107
148B:B:M325 5.75645
149B:B:T329 5.9725108
150B:B:W332 12.3387819
151B:B:L336 5.3425447
152B:B:K337 10.974106
153B:B:W339 8.747147109
154G:G:L37 4.76437
155G:G:M38 3.6275434
156G:G:Y40 16.02436
157G:G:C41 4.54437
158G:G:L50 3.945409
159G:G:L51 5.89406
160G:G:V54 9.31546
161G:G:F61 5.83429748
162H:H:?1 20.395150
163L:L:V2 5.592520
164L:L:S3 6.5975420
165L:L:E4 6.224520
166L:L:I5 6.272520
167L:L:Q6 8.69667620
168L:L:M8 3.284520
169L:L:H9 6.634520
170L:L:H14 3.8825420
171L:L:W23 9.306570
172L:L:L24 5.32570
173L:L:L28 5.72470
174R:R:K34 4.545474
175R:R:E111 6.98477
176R:R:W112 6.8225227
177R:R:D113 6.72479
178R:R:I115 4.242575
179R:R:L116 5.6575475
180R:R:W118 13.602579
181R:R:P132 6.8075479
182R:R:Y134 6.46505
183R:R:I135 6.9225477
184R:R:F138 8.548574
185R:R:H143 3.6954183
186R:R:Y145 5.7554184
187R:R:R146 14.434578
188R:R:W154 11.835479
189R:R:T163 4.62475
190R:R:Y167 6.7575
191R:R:F184 5.75426
192R:R:L187 5.255425
193R:R:Y191 5.826527
194R:R:Y195 6.55857727
195R:R:L199 2.97754237
196R:R:L202 4.845409
197R:R:F212 7.7365247
198R:R:L215 5.254249
199R:R:R219 8.13714789
200R:R:H223 6.155409
201R:R:L226 7.4025429
202R:R:F227 4.76333609
203R:R:F230 8.51286728
204R:R:M231 2.8754238
205R:R:R233 8.68728
206R:R:I237 4.622527
207R:R:K240 7.8125427
208R:R:L244 6.47625
209R:R:F288 7.44427
210R:R:L289 4.918527
211R:R:Y290 7.16409
212R:R:N295 11.725428
213R:R:Y296 8.70667627
214R:R:Y297 5.22254266
215R:R:W298 11.3365259
216R:R:I299 4.906529
217R:R:L300 6.335408
218R:R:E302 11.0725409
219R:R:Y305 5.0225888
220R:R:L309 7.63488
221R:R:I310 4.7725408
222R:R:F311 7.16754276
223R:R:F314 5.32254127
224R:R:F315 6.13686
225R:R:F324 4.385487
226R:R:L331 3.654264
227R:R:W339 9.155428
228R:R:V342 3.09405
229R:R:R343 9.216528
230R:R:W352 11.57628
231R:R:K360 8.094527
232R:R:W361 6.8825428
233R:R:Q364 6.752527
234R:R:F378 6.4325169
235R:R:L413 5.4825409
236R:R:F417 6.344509
237R:R:H420 8.48528
238R:R:Y421 10.77728
239R:R:F424 8.38833627
240R:R:M425 2.6225406
241R:R:T427 7.115425
242R:R:Y429 12.4975426
243R:R:V432 8.9275425
244R:R:W437 8.07725
245R:R:Q440 8.36833626
246R:R:M441 7.12833626
247R:R:Y443 7.238524
248R:R:E444 8.445427
249R:R:M445 4.5875406
250R:R:N448 8.402526
251R:R:F450 5.4725427
252R:R:Q451 7.232529
253R:R:Y459 8.29508
254R:R:C460 3.686509
255R:R:N463 6.515489
256R:R:E469 10.62754249
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:K89 B:B:W82 12.62289.28YesYes099
2B:B:L70 B:B:W82 13.81616.83NoYes059
3A:A:L30 B:B:K78 10.81924.23YesNo068
4A:A:D33 B:B:K78 10.50678.3NoNo058
5G:G:F61 G:G:P60 17.77878.67YesNo489
6B:B:M325 G:G:P60 30.80015.03YesNo459
7B:B:M325 G:G:N59 46.64154.21YesNo459
8B:B:N340 G:G:N59 48.39415.45NoNo099
9B:B:N340 G:G:L50 48.67052.75NoYes099
10B:B:V327 G:G:L50 41.57032.98NoYes069
11B:B:L286 B:B:V327 41.43032.98NoNo076
12B:B:L286 B:B:L318 93.94374.15NoNo076
13B:B:L318 B:B:S275 99.81273NoNo068
14B:B:S275 B:B:T274 1004.8NoNo088
15B:B:D290 B:B:T274 47.04457.23NoNo168
16A:A:W281 B:B:D290 47.12127.82YesNo156
17A:A:N279 A:A:W281 94.98233.39NoYes185
18A:A:L282 A:A:N279 82.12639.61YesNo198
19A:A:I244 A:A:L282 69.8915.71YesYes189
20A:A:I244 A:A:V287 89.88823.07YesNo086
21A:A:V287 A:A:W277 89.85444.9NoYes066
22A:A:H357 A:A:W277 98.88921.16NoYes076
23A:A:H357 A:A:S286 98.71112.79NoNo078
24A:A:S286 A:A:Y360 98.51173.82NoYes1488
25B:B:T321 B:B:W63 13.683712.13NoYes477
26B:B:D323 B:B:T321 13.92377.23NoNo477
27B:B:D323 B:B:M325 15.10665.54NoYes475
28B:B:R314 B:B:T274 53.143112.94YesNo188
29A:A:W281 B:B:R314 47.09713YesYes158
30A:A:I235 A:A:N279 12.88785.66YesNo198
31A:A:I235 A:A:L46 12.49922.85YesYes198
32A:A:L44 A:A:W234 20.64693.42YesYes199
33A:A:W234 B:B:Y145 29.49172.89YesYes198
34A:A:I276 A:A:L282 12.52172.85YesYes189
35A:A:F246 A:A:L46 18.43.65YesYes198
36A:A:F246 A:A:I276 15.08346.28YesYes198
37B:B:G162 B:B:S161 31.02783.71NoYes199
38B:B:G162 B:B:Y145 31.0094.35NoYes198
39A:A:F246 A:A:V248 13.15073.93YesNo097
40A:A:F246 A:A:F273 23.21568.57YesYes199
41A:A:F345 A:A:V248 12.73826.55YesNo087
42A:A:F273 A:A:F345 15.31549.65YesYes198
43A:A:L289 A:A:L291 12.32874.15YesNo198
44A:A:F363 A:A:L291 10.81757.31YesNo158
45A:A:F345 A:A:L270 29.594312.18YesYes186
46A:A:F312 A:A:L270 18.20083.65YesYes186
47A:A:F312 A:A:F340 16.71155.36YesYes187
48A:A:D381 A:A:Y360 93.60269.2NoYes088
49A:A:D381 A:A:Q385 93.52593.92NoNo085
50A:A:L388 A:A:Q385 93.30063.99YesNo2085
51A:A:L388 R:R:I310 12.49982.85YesYes088
52R:R:I310 R:R:L306 11.6214.28YesNo089
53A:A:Y391 R:R:L306 12.398818.76YesNo049
54A:A:L388 A:A:L393 80.49465.54YesNo088
55A:A:L393 R:R:L413 80.2778.3NoYes089
56B:B:I43 B:B:V40 59.04123.07YesYes333
57B:B:R283 B:B:V40 56.82835.23YesYes393
58B:B:L300 B:B:R283 36.06358.5YesYes369
59B:B:L300 B:B:T34 16.71282.95YesNo365
60B:B:L30 B:B:T34 16.48035.9YesNo355
61B:B:L261 B:B:L30 19.17244.15NoYes055
62B:B:L261 G:G:V30 19.35794.47NoNo058
63B:B:Q259 G:G:V30 18.34635.73YesNo2168
64B:B:Q259 B:B:R22 16.91424.67YesYes066
65B:B:L300 G:G:M38 19.34014.24YesYes364
66B:B:L30 G:G:M38 16.78242.83YesYes354
67B:B:L30 B:B:M262 14.99525.65YesYes354
68B:B:I43 B:B:V296 50.200310.75YesYes335
69B:B:L286 B:B:V296 52.53434.47NoYes075
70B:B:R68 B:B:Y85 11.040925.72NoYes454
71B:B:D66 B:B:R68 10.76413.57NoNo085
72B:B:D66 B:B:L69 10.5069.5NoNo085
73B:B:H142 B:B:S161 29.255212.55YesYes199
74B:B:H142 B:B:T159 17.91958.21YesYes199
75B:B:C149 B:B:T159 17.83593.38YesYes189
76B:B:C149 B:B:T102 17.60035.07YesNo088
77B:B:C148 B:B:T102 17.4583.38NoNo068
78B:B:H142 B:B:W169 10.07096.35YesYes198
79B:B:C148 B:B:L190 14.95686.35NoNo065
80B:B:G202 B:B:I229 14.18683.53NoYes067
81B:B:G202 B:B:H183 14.21193.18NoYes069
82B:B:H183 B:B:V187 11.04565.54YesYes699
83B:B:L190 B:B:S160 12.47089.01NoNo056
84B:B:R283 G:G:C41 20.87124.18YesYes397
85B:B:F235 G:G:C41 20.76014.19YesYes367
86B:B:M262 B:B:Y264 13.86219.58YesYes345
87B:B:W297 B:B:Y264 22.607115.43YesYes385
88R:R:F417 R:R:L413 76.97596.09YesYes099
89R:R:F417 R:R:N374 75.14468.46YesNo099
90R:R:I299 R:R:N374 72.9054.25YesNo099
91R:R:I299 R:R:N295 69.59375.66YesYes298
92R:R:N295 R:R:R233 81.523914.46YesYes288
93L:L:E4 R:R:R233 50.48533.49YesYes208
94L:L:E4 R:R:M445 43.08718.12YesYes006
95R:R:L187 R:R:M445 42.1624.24YesYes056
96R:R:H442 R:R:L187 40.11677.71NoYes055
97R:R:H442 R:R:R186 39.911410.16NoNo055
98R:R:E182 R:R:R186 39.29391.16NoNo025
99H:H:?1 R:R:E182 39.08774.76YesNo002
100H:H:?1 R:R:T178 38.241215.87YesNo1503
101R:R:L292 R:R:R233 13.40567.29NoYes268
102L:L:I5 R:R:L292 13.31422.85YesNo206
103R:R:R233 R:R:Y195 15.395313.38YesYes287
104L:L:E4 R:R:I237 10.00445.47YesYes207
105R:R:F288 R:R:I237 12.77873.77YesYes277
106R:R:K240 R:R:L244 13.26364.23YesYes275
107R:R:E177 R:R:T178 38.0721.41NoNo013
108L:L:R25 R:R:E177 37.6569.3NoNo001
109L:L:R25 R:R:L174 37.44898.5NoNo003
110R:R:L174 R:R:V171 37.24174.47NoNo033
111L:L:L28 R:R:V171 37.03275.96YesNo003
112L:L:L28 R:R:I115 26.26742.85YesYes705
113R:R:I115 R:R:L116 17.69472.85YesYes755
114R:R:D113 R:R:L116 10.29534.07YesYes795
115R:R:W118 R:R:Y167 13.92067.72YesYes795
116R:R:V129 R:R:W118 13.99216.13NoYes059
117R:R:P130 R:R:V129 11.90633.53NoNo055
118R:R:H143 R:R:P130 11.20783.05YesNo035
119R:R:F227 R:R:H223 12.39144.53YesYes099
120R:R:C351 R:R:L244 11.17433.17NoYes295
121B:B:Y85 G:G:P60 12.7418.08YesNo449
122A:A:I244 A:A:L44 19.84715.71YesYes189
123B:B:S160 B:B:V187 11.71236.46NoYes669
124R:R:F230 R:R:N295 10.98619.33YesYes288
125R:R:H223 R:R:R219 11.80464.51YesYes099
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:S1 R:R:Q440 5.78 2 No Yes 0 6 0 1
L:L:V2 R:R:Y296 3.79 2 Yes Yes 0 7 0 1
L:L:V2 R:R:Q364 4.3 2 Yes Yes 0 7 0 1
L:L:V2 R:R:I367 6.14 2 Yes No 0 7 0 1
L:L:V2 R:R:L368 2.98 2 Yes No 0 4 0 1
L:L:S3 R:R:Q440 5.78 2 Yes Yes 0 6 0 1
L:L:S3 R:R:M441 4.6 2 Yes Yes 0 6 0 1
L:L:S3 R:R:E444 12.94 2 Yes Yes 0 7 0 1
L:L:S3 R:R:M445 3.07 2 Yes Yes 0 6 0 1
L:L:E4 R:R:Y195 10.1 2 Yes Yes 0 7 0 1
L:L:E4 R:R:R233 3.49 2 Yes Yes 0 8 0 1
L:L:E4 R:R:I237 5.47 2 Yes Yes 0 7 0 1
L:L:E4 R:R:M445 8.12 2 Yes Yes 0 6 0 1
L:L:E4 R:R:N448 3.94 2 Yes Yes 0 6 0 1
L:L:I5 R:R:L289 2.85 2 Yes Yes 0 7 0 1
L:L:I5 R:R:L292 2.85 2 Yes No 0 6 0 1
L:L:I5 R:R:Q364 9.61 2 Yes Yes 0 7 0 1
L:L:Q6 R:R:Y429 23.67 2 Yes Yes 0 6 0 1
L:L:Q6 R:R:W437 4.38 2 Yes Yes 0 5 0 1
L:L:Q6 R:R:Q440 6.4 2 Yes Yes 0 6 0 1
L:L:Q6 R:R:M441 6.8 2 Yes Yes 0 6 0 1
L:L:L7 R:R:M441 2.83 0 No Yes 0 6 0 1
L:L:M8 R:R:K240 2.88 2 Yes Yes 0 7 0 1
L:L:M8 R:R:L244 2.83 2 Yes Yes 0 5 0 1
L:L:M8 R:R:V285 3.04 2 Yes No 0 6 0 1
L:L:M8 R:R:F288 3.73 2 Yes Yes 0 7 0 1
L:L:H9 R:R:S355 9.76 2 Yes No 0 7 0 1
L:L:H9 R:R:K360 6.55 2 Yes Yes 0 7 0 1
L:L:H9 R:R:Y429 7.62 2 Yes Yes 0 6 0 1
L:L:N10 R:R:V432 4.43 2 No Yes 0 5 0 1
L:L:N10 R:R:W437 5.65 2 No Yes 0 5 0 1
L:L:L11 R:R:F184 8.53 0 No Yes 0 6 0 1
L:L:L11 R:R:Y245 14.07 0 No No 0 4 0 1
L:L:H14 R:R:R181 4.51 2 Yes No 0 3 0 1
L:L:H14 R:R:F184 4.53 2 Yes Yes 0 6 0 1
L:L:L15 R:R:R181 4.86 2 No No 0 3 0 1
L:L:N16 R:R:V31 7.39 0 No No 0 6 0 1
L:L:N16 R:R:L354 4.12 0 No No 0 5 0 1
L:L:E19 R:R:T33 2.82 0 No No 0 7 0 1
L:L:R20 R:R:Y136 6.17 0 No No 0 4 0 1
L:L:R20 R:R:D137 11.91 0 No No 0 5 0 1
L:L:V21 R:R:E177 8.56 0 No No 0 1 0 1
L:L:W23 R:R:K34 6.96 7 Yes Yes 0 4 0 1
L:L:W23 R:R:Q37 16.43 7 Yes No 0 7 0 1
L:L:W23 R:R:I38 5.87 7 Yes No 0 7 0 1
L:L:L24 R:R:I135 2.85 7 Yes Yes 0 7 0 1
L:L:L24 R:R:D137 4.07 7 Yes No 0 5 0 1
L:L:L24 R:R:F138 7.31 7 Yes Yes 0 4 0 1
L:L:R25 R:R:L174 8.5 0 No No 0 3 0 1
L:L:R25 R:R:E177 9.3 0 No No 0 1 0 1
L:L:K27 R:R:L41 7.05 0 No No 0 8 0 1
L:L:K27 R:R:I115 5.82 0 No Yes 0 5 0 1
L:L:L28 R:R:I115 2.85 7 Yes Yes 0 5 0 1
L:L:L28 R:R:F138 8.53 7 Yes Yes 0 4 0 1
L:L:L28 R:R:V171 5.96 7 Yes No 0 3 0 1
L:L:V31 R:R:I115 4.61 0 No Yes 0 5 0 1
L:L:V31 R:R:Y167 8.83 0 No Yes 0 5 0 1
L:L:F34 R:R:E111 10.49 0 No Yes 0 7 0 1
L:L:F34 R:R:D113 4.78 0 No Yes 0 9 0 1
L:L:?35 R:R:T163 3.65 0 No Yes 0 5 0 1
R:R:M32 R:R:Y136 5.99 0 No No 6 4 2 1
R:R:E35 R:R:T33 4.23 0 No No 5 7 2 1
R:R:E35 R:R:K34 4.05 0 No Yes 5 4 2 1
R:R:I38 R:R:K34 5.82 7 No Yes 7 4 1 1
R:R:H42 R:R:I38 6.63 0 No No 4 7 2 1
R:R:H42 R:R:L41 3.86 0 No No 4 8 2 1
R:R:L41 R:R:Y134 5.86 0 No Yes 8 5 1 2
R:R:E111 R:R:R146 6.98 7 Yes Yes 7 8 1 2
R:R:E111 R:R:W154 7.63 7 Yes Yes 7 9 1 2
R:R:E111 R:R:T163 2.82 7 Yes Yes 7 5 1 1
R:R:W112 R:R:Y134 2.89 22 Yes Yes 7 5 2 2
R:R:D113 R:R:L116 4.07 7 Yes Yes 9 5 1 2
R:R:D113 R:R:W118 12.28 7 Yes Yes 9 9 1 2
R:R:D113 R:R:Y167 5.75 7 Yes Yes 9 5 1 1
R:R:I115 R:R:L116 2.85 7 Yes Yes 5 5 1 2
R:R:I115 R:R:P132 5.08 7 Yes Yes 5 9 1 2
R:R:L116 R:R:P132 9.85 7 Yes Yes 5 9 2 2
R:R:L116 R:R:Y167 5.86 7 Yes Yes 5 5 2 1
R:R:A144 R:R:W118 3.89 7 No Yes 7 9 2 2
R:R:R146 R:R:W118 37.99 7 Yes Yes 8 9 2 2
R:R:W118 R:R:Y167 7.72 7 Yes Yes 9 5 2 1
R:R:I135 R:R:P132 5.08 7 Yes Yes 7 9 1 2
R:R:F138 R:R:P132 7.22 7 Yes Yes 4 9 1 2
R:R:I135 R:R:Y134 8.46 7 Yes Yes 7 5 1 2
R:R:F138 R:R:I135 11.3 7 Yes Yes 4 7 1 1
R:R:C170 R:R:F138 8.38 0 No Yes 9 4 2 1
R:R:A144 R:R:Y167 5.34 7 No Yes 7 5 2 1
R:R:R146 R:R:W154 13.99 7 Yes Yes 8 9 2 2
R:R:R146 R:R:T163 9.06 7 Yes Yes 8 5 2 1
R:R:L156 R:R:T163 2.95 0 No Yes 4 5 2 1
R:R:R162 R:R:V157 9.15 0 No No 3 4 1 2
R:R:H160 R:R:R162 19.18 0 No No 4 3 2 1
R:R:L174 R:R:V171 4.47 0 No No 3 3 1 1
R:R:E180 R:R:V432 11.41 0 No Yes 3 5 2 1
R:R:D185 R:R:R181 9.53 0 No No 2 3 2 1
R:R:F184 R:R:V432 3.93 2 Yes Yes 6 5 1 1
R:R:F184 R:R:W437 6.01 2 Yes Yes 6 5 1 1
R:R:L187 R:R:W437 3.42 2 Yes Yes 5 5 2 1
R:R:L187 R:R:M441 5.65 2 Yes Yes 5 6 2 1
R:R:L187 R:R:M445 4.24 2 Yes Yes 5 6 2 1
R:R:I190 R:R:M445 2.92 0 No Yes 6 6 2 1
R:R:Y191 R:R:Y195 3.97 2 Yes Yes 7 7 2 1
R:R:I237 R:R:Y191 3.63 2 Yes Yes 7 7 1 2
R:R:D241 R:R:Y191 8.05 2 No Yes 8 7 2 2
R:R:R233 R:R:Y195 13.38 2 Yes Yes 8 7 1 1
R:R:A234 R:R:Y195 4 0 No Yes 8 7 2 1
R:R:I237 R:R:Y195 6.04 2 Yes Yes 7 7 1 1
R:R:S449 R:R:Y195 6.36 2 No Yes 9 7 2 1
R:R:L292 R:R:R233 7.29 2 No Yes 6 8 1 1
R:R:N295 R:R:R233 14.46 2 Yes Yes 8 8 2 1
R:R:R233 R:R:Y296 14.4 2 Yes Yes 8 7 1 1
R:R:R233 R:R:Y421 4.12 2 Yes Yes 8 8 1 2
R:R:N448 R:R:R233 3.62 2 Yes Yes 6 8 1 1
R:R:D241 R:R:I237 4.2 2 No Yes 8 7 2 1
R:R:F288 R:R:I237 3.77 2 Yes Yes 7 7 1 1
R:R:D241 R:R:K240 5.53 2 No Yes 8 7 2 1
R:R:K240 R:R:L244 4.23 2 Yes Yes 7 5 1 1
R:R:F288 R:R:K240 18.61 2 Yes Yes 7 7 1 1
R:R:L244 R:R:Y245 10.55 2 Yes No 5 4 1 1
R:R:L244 R:R:V285 4.47 2 Yes No 5 6 1 1
R:R:C351 R:R:L244 3.17 2 No Yes 9 5 2 1
R:R:D353 R:R:L244 13.57 2 No Yes 5 5 2 1
R:R:L289 R:R:V285 2.98 2 Yes No 7 6 1 1
R:R:F288 R:R:L289 3.65 2 Yes Yes 7 7 1 1
R:R:L289 R:R:W339 7.97 2 Yes Yes 7 8 1 2
R:R:I363 R:R:L289 7.14 2 No Yes 7 7 2 1
R:R:L292 R:R:Y296 5.86 2 No Yes 6 7 1 1
R:R:A293 R:R:I367 3.25 0 No No 6 7 2 1
R:R:I367 R:R:Y296 8.46 2 No Yes 7 7 1 1
R:R:I371 R:R:Y296 4.84 2 No Yes 7 7 2 1
R:R:Y296 R:R:Y421 14.89 2 Yes Yes 7 8 1 2
R:R:I363 R:R:W339 8.22 2 No Yes 7 8 2 2
R:R:C351 R:R:D353 3.11 2 No No 9 5 2 2
R:R:D353 R:R:L354 8.14 2 No No 5 5 2 1
R:R:K360 R:R:S355 6.12 2 Yes No 7 7 1 1
R:R:K360 R:R:W361 10.44 2 Yes Yes 7 8 1 2
R:R:K360 R:R:Q364 5.42 2 Yes Yes 7 7 1 1
R:R:K360 R:R:Y429 11.94 2 Yes Yes 7 6 1 1
R:R:Q364 R:R:W361 7.67 2 Yes Yes 7 8 1 2
R:R:Q364 R:R:Y429 6.76 2 Yes Yes 7 6 1 1
R:R:I371 R:R:Y421 9.67 2 No Yes 7 8 2 2
R:R:H420 R:R:Y421 18.51 2 Yes Yes 8 8 2 2
R:R:H420 R:R:Y443 3.27 2 Yes Yes 8 4 2 2
R:R:H420 R:R:N448 7.65 2 Yes Yes 8 6 2 1
R:R:N448 R:R:Y421 16.28 2 Yes Yes 6 8 1 2
R:R:F424 R:R:T427 7.78 2 Yes Yes 7 5 2 2
R:R:F424 R:R:Q440 14.05 2 Yes Yes 7 6 2 1
R:R:F424 R:R:Y443 8.25 2 Yes Yes 7 4 2 2
R:R:E444 R:R:F424 5.83 2 Yes Yes 7 7 1 2
R:R:Q440 R:R:T427 12.76 2 Yes Yes 6 5 1 2
R:R:T430 R:R:W437 3.64 0 No Yes 5 5 2 1
R:R:V432 R:R:W437 15.94 2 Yes Yes 5 5 1 1
R:R:M441 R:R:W437 17.45 2 Yes Yes 6 5 1 1
R:R:M441 R:R:Q440 5.44 2 Yes Yes 6 6 1 1
R:R:E444 R:R:Y443 4.49 2 Yes Yes 7 4 1 2
R:R:E444 R:R:N448 10.52 2 Yes Yes 7 6 1 1
L:L:D30 R:R:H114 2.52 0 No No 0 4 0 1
L:L:H32 R:R:R162 2.26 0 No No 0 3 0 1
R:R:F238 R:R:Y195 2.06 0 No Yes 7 7 2 1
R:R:G357 R:R:S355 1.86 0 No No 6 7 2 1
L:L:G12 R:R:L354 1.71 0 No No 0 5 0 1
R:R:E177 R:R:T178 1.41 0 No No 1 3 1 2
L:L:E22 R:R:K34 1.35 0 No Yes 0 4 0 1
R:R:H114 R:R:W112 1.06 0 No Yes 4 7 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
80.00Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
77.42Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
77.42Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
75.00Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
75.00Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
74.19Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
73.33Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
73.33Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
67.74Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
66.67Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
66.67Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
64.52Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
64.52Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
63.89Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
62.50Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
62.50Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
61.29Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
60.61Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
60.00Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
57.58Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
57.58Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
54.55Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
54.29Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
53.57Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
53.12Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
52.78Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
51.52Single6FJ3PTH6FJ3-PTH1-PTH
51.52Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
51.52Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
51.52Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
51.52Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
51.35Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
50.00Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
50.00Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
50.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
50.00Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
48.57Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
48.57Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
48.48Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
48.48Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
48.48Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
48.48Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
47.22Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
47.06Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
47.06Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
47.06Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
47.06Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
46.88Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
46.15Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
45.71Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
45.71Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
45.71Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
44.44Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
44.12Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
42.86Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
42.86Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
42.11Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
41.67Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
41.67Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
41.18Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
41.18Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
41.18Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
41.18Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
41.18Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
41.18Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
41.18Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
40.54Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
40.54Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
40.54Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
40.00Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
40.00Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
40.00Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
39.47Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
39.39Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
39.39Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
38.46Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
38.24Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
37.84Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
37.50Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
37.50Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
37.50Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
37.14Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
36.84Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
36.84Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
36.84Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
36.59Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
36.36Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
36.36Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
36.11Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
35.90Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
35.48Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
35.48Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
35.48Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
35.00Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
35.00Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
34.38Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
34.38Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
34.29Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
34.21Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
34.21Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
34.21Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
33.33Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
33.33Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
33.33Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
33.33Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
33.33Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
33.33Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
33.33Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
33.33Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
33.33Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
32.43Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
32.35Single7QA8Peptide7QA8-STE2-Peptide
32.35Single7QA8Peptide7QA8-STE2-Peptide
32.26Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
32.26Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
32.26Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
32.26Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
32.26Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
32.26Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
31.58Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
31.43Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
31.25Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
31.25Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
31.25Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
31.25Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
31.25Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
31.25Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
31.25Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
31.25Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
31.03Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
30.77Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
30.77Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
30.30Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
30.30Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
30.30Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
30.30Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
30.00Single7V3ZCP559407V3Z-CB1-CP55940
29.79Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
29.73Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
29.41Single5EE7MK08935EE7-Glucagon-MK0893
29.41Single5ZTYAM102575ZTY-CB2-AM10257
29.41Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
29.41Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
29.41Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
29.03Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
29.03Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
29.03Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
29.03Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
29.03Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
29.03Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
28.57Single4XT1Fractalkine4XT1-US28-Fractalkine
28.57Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
28.57Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
28.57Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
28.12Single5XR8AM8415XR8-CB1-AM841
28.12Single5XRAAM115425XRA-CB1-AM11542
28.12Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
28.12Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
27.78Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
27.78Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
27.78Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
27.78Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
27.50Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
27.50Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
27.50Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
27.50Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
27.50Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
27.50Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
27.27Single6KQICP559406KQI-CB1-CP55940-Org27569
27.27Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
27.27Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
27.27Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
27.27Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
27.27Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
27.27Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
27.27Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
27.27Consensuslpl_offOrthosteric Ligands1p_off lpa_off
27.27Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
27.03Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
27.03Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
27.03Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
26.83Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
26.83Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
26.67Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
26.67Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
26.67Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
26.47Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
26.47Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
26.47Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
26.47Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
26.47Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
26.32Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
26.32Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
26.32Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.32Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
26.32Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
26.19Single6IGKEndothelin-36IGK-ETB-Endothelin-3
26.19Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
26.19Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
26.19Consensusbombesin_onOrthosteric Ligandbb2_on
26.19Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
26.19Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
25.81Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
25.81Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
25.81Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
25.81Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
25.81Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
25.81Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
25.71Single4UG2CGS216804UG2-A2A-CGS21680
25.71Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
25.71Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
25.71Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
25.71Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
25.71Single8QJ2pN1628QJ2-MC4-pN162-Gs
25.64Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
25.64Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
25.64Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
25.64Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
25.64Single8ZRTET-18ZRT-ETB-ET-1
25.64Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
25.64Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
25.64Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
25.64Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.00Single4XT3Fractalkine4XT3-US28-Fractalkine
25.00Single7C4SS1P7C4S-S1P3-S1P
25.00Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
25.00Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
25.00Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
25.00Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
25.00Single8TF5Oleic acid8TF5-GPR6-Oleic acid
25.00Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
25.00Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
25.00Consensuslpl_onOrthosteric Ligands1p_on lpa_on
25.00Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
25.00Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
25.00Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
25.00Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
24.39Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
24.39Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
24.39Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
24.39Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
24.32Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
24.32Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
24.32Single7XNACYN1548067XNA-SST2-CYN154806
24.32Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
24.32Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
24.32Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
24.24Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
24.24Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
24.24Single7FEECP559407FEE-CB1-CP55940-ZCZ011
24.24Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
24.24Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
24.24Single8E0GBU728E0G-μ-BU72
24.24Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
24.24Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
24.24Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
24.24Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
23.68Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
23.68Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
23.68Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
23.68Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
23.53Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
23.53Single7DFPSpiperone7DFP-D2-Spiperone
23.53Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
23.53Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
23.53Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
23.53Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
23.53Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
23.53Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
23.40Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
23.40Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
23.33Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
23.33Single5U09Taranabant5U09-CB1-Taranabant
23.33Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
23.33Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
23.33Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
23.33Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
23.26Single5GLHEndothelin-15GLH-ETB-Endothelin-1
23.26Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
23.26Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
23.26Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
23.26Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
23.08Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
23.08Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
23.08Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
23.08Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
23.08Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
23.08Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
22.86Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
22.86Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
22.86Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
22.86Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
22.86Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
22.86Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
22.86Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
22.86Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
22.86Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
22.86Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
22.73Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
22.73Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
22.58Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
22.58Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
22.58Single8K5CAcipimox8K5C-HCA2-Acipimox
22.58Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
22.58Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
22.58Consensushca_onOrthosteric Ligandhca2_on
22.50Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
22.50Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
22.50Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
22.50Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
22.50Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
22.50Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
22.50Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
22.22Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
22.22Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
22.22Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
22.22Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
22.22Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
22.22Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
22.22Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
22.22Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
22.22Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
21.95Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
21.95Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
21.95Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
21.95Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
21.88Single5TGZAM65385TGZ-CB1-AM6538
21.88Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
21.88Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
21.88Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
21.88Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
21.88Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
21.88Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
21.88Single9B9ZA1AKO9B9Z-CB1-A1AKO
21.88Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
21.88Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
21.88Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
21.88Consensushca_on_gpOrthosteric Ligandhca2_on_gp
21.62Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
21.62Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
21.62Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
21.62Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
21.62Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
21.62Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
21.62Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
21.62Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
21.62Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
21.62Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
21.62Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
21.62Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
21.62Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
21.62Consensussomatostatin_offOrthosteric Ligandsst2_off
21.43Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
21.43Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
21.43Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
21.21Single5C1MBU725C1M-μ-BU72
21.21Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
21.21Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
21.21Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
21.21Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
21.21Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.21Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
21.21Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
21.21Single8JXSPF-61428JXS-D1-PF-6142
21.21Single8S4DCMF-0198S4D-Apelin-CMF-019
21.21Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
21.21Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
21.21Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
21.21Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
21.21Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
21.05Single3QAKUK-4320973QAK-A2A-UK-432097
21.05Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
21.05Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
21.05Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
21.05Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
21.05Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
21.05Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
21.05Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
21.05Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
21.05Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
21.05Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
21.05Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
20.93Single6IGLIRL16206IGL-ETB-IRL1620
20.93Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
20.93Single8IY6Endothelin-18IY6-ETB-Endothelin-1
20.93Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
20.93Consensusendothelin_onOrthosteric Ligandetb_on eta_on
20.93Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
20.75Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
20.69Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
20.59Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
20.59Single4BV0Neurotensin4BV0-NTS1-Neurotensin
20.59Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
20.59Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
20.59Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
20.59Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
20.59Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
20.59Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
20.59Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
20.59Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
20.59Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
20.59Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
20.59Single8EA0Iperoxo8EA0-M3-Iperoxo
20.59Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
20.59Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.59Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
20.59Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
20.59Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
20.59Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
20.59Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
20.59Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.59Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.59Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
20.59Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
20.59Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
20.59Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
20.59Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
20.59Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
20.59Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
20.59Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.59Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
20.59Consensusneurotensin_onOrthosteric Ligandnts1_on
20.59Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
20.59Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
20.51Single5WF5UK-4320975WF5-A2A-UK-432097
20.51Single6W25SHU91196W25-MC4-SHU9119-Ca
20.51Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
20.51Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
20.51Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
20.51Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
20.51Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
20.51Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.51Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.51Consensusangiotensin_onOrthosteric Ligandat1_on
20.51Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
20.51Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
20.51Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
20.51Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
20.51Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
20.51Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
20.51Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
20.51Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
20.51Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
20.51Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
20.00Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
20.00Single4XEENeurotensin4XEE-NTS1-Neurotensin
20.00Single4XESNeurotensin4XES-NTS1-Neurotensin
20.00Single6A93Risperidone6A93-5-HT2A-Risperidone
20.00Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
20.00Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
20.00Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
20.00Single6YVRNTS8-136YVR-NTS1-NTS8-13
20.00Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
20.00Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
20.00Single7K15MKD0467K15-BLT1-MKD046-Na
20.00Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
20.00Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
20.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
20.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
20.00Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
20.00Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
20.00Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
20.00Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
20.00Single7YITNalfurafine7YIT-κ-Nalfurafine
20.00Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
20.00Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
20.00Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
20.00Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
20.00Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
20.00Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
20.00Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
20.00Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
20.00Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
20.00Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
20.00Single8K5BNiacin8K5B-HCA2-Niacin
20.00Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
20.00Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.00Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
20.00Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
20.00Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
20.00Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
20.00Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
20.00Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
20.00Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
20.00Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
20.00Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
20.00Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
20.00Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
20.00Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
20.00Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
20.00Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
20.00Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
20.00Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
20.00Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
20.00Consensuslpa_offOrthosteric Ligandlpa1_off
20.00Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
20.00Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
20.00Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
20.00Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
20.00Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
20.00Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
20.00Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
20.00Consensusorexin_onOrthosteric Ligandox2_on
20.00Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
19.51Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
19.51Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
19.51Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
19.51Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
19.51Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
19.51Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
19.51Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
19.51Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
19.51Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
19.51Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
19.51Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
19.44Single4BUONeurotensin4BUO-NTS1-Neurotensin
19.44Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
19.44Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
19.44Single5X93K-87945X93-ETB-K-8794
19.44Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
19.44Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
19.44Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
19.44Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
19.44Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
19.44Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
19.44Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
19.44Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
19.44Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
19.44Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
19.44Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
19.44Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
19.44Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
19.44Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
19.44Consensuscck_onOrthosteric Ligandccka_on cckb_on
19.44Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
19.44Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
19.44Consensusendothelin_offOrthosteric Ligandetb_off
19.44Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
19.44Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.44Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.44Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
19.44Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
19.44Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
19.44Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
19.44Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
19.44Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
19.44Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
19.44Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
19.35Single4BWBNeurotensin4BWB-NTS1-Neurotensin
19.35Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
19.35Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
19.35Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
19.35Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
19.35Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
19.35Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
19.35Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
19.35Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
19.35Single8Y0HVUF114188Y0H-CXCR3-VUF11418
19.35Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
19.35Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
19.35Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
19.35Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
19.15Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
19.05Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
19.05Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
19.05Single7SK3CXCL127SK3-ACKR3-CXCL12
19.05Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
19.05Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
19.05Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
19.05Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
19.05Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
19.05Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
19.05Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
18.92Single3NY9ICI118-5513NY9-β2-ICI118-551
18.92Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
18.92Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
18.92Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
18.92Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
18.92Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.92Single7SK9CCX6627SK9-ACKR3-CCX662
18.92Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
18.92Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
18.92Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
18.92Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
18.92Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
18.75Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
18.75Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.75Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
18.75Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
18.75Single8IHKAcifran8IHK-HCA3-Acifran
18.75Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
18.75Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
18.75Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
18.75Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
18.75Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
18.75Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
18.75Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
18.75Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
18.75Consensusgrh_offOrthosteric Ligandgnrh1_off
18.60Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
18.60Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
18.60Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
18.42Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
18.42Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
18.42Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
18.42Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
18.42Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
18.42Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
18.42Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
18.42Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
18.42Single8IEBA1LYA8IEB-GPR156-A1LYA
18.42Single8IEIA1LYA8IEI-GPR156-A1LYA
18.42Single8IEPA1LYA8IEP-GPR156-A1LYA
18.42Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
18.42Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
18.42Single8WDTphotoNECA8WDT-A2A-photoNECA
18.42Single8WKYPG-9348WKY-MC4-PG-934
18.42Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.42Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
18.42Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
18.42Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
18.42Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
18.42Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
18.42Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
18.18Single4DAJTiotropium4DAJ-M3-Tiotropium
18.18Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
18.18Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
18.18Single4YAYZD-71554YAY-AT1-ZD-7155
18.18Single5T04Neurotensin5T04-NTS1-Neurotensin
18.18Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
18.18Single6TOTLemborexant6TOT-OX1-Lemborexant
18.18Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
18.18Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
18.18Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
18.18Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
18.18Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
18.18Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
18.18Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
18.18Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
18.18Single7YXAONO-54306087YXA-S1P5-ONO-5430608
18.18Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
18.18Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
18.18Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
18.18Single8K5DGSK2560738K5D-HCA2-GSK256073
18.18Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
18.18Single8T1WCVN4248T1W-GPR6-CVN424
18.18Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
18.18Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
18.18Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
18.18Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
18.18Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
18.18Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
18.18Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
17.95Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
17.95Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
17.95Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
17.95Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
17.95Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
17.95Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
17.95Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
17.95Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
17.95Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
17.95Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
17.95Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
17.95Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
17.95Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
17.95Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
17.95Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
17.95Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
17.95Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
17.78Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
17.78Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
17.78Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
17.65Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
17.65Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
17.65Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
17.65Single6TP6Filorexant6TP6-OX1-Filorexant
17.65Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
17.65Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
17.65Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
17.65Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
17.65Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
17.65Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
17.65Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
17.65Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
17.65Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
17.65Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
17.65Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.65Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
17.65Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
17.65Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
17.65Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
17.65Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
17.65Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
17.65Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
17.65Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
17.65Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
17.65Consensusblt_offOrthosteric Ligandblt1_off
17.65Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
17.65Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.65Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
17.50Single3OE0CVX153OE0-CXCR4-CVX15
17.50Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
17.50Single6PT2KGCHM076PT2-δ-KGCHM07
17.50Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
17.50Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
17.50Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
17.50Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
17.50Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
17.50Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
17.50Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
17.50Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
17.50Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
17.39Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
17.39Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
17.24Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
17.14Single2YDVNECA2YDV-A2A-NECA
17.14Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
17.14Single4DJHJDTic4DJH-κ-JDTic
17.14Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
17.14Single4UHRCGS216804UHR-A2A-CGS21680
17.14Single5G53NECA5G53-A2A-NECA-Gs
17.14Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
17.14Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
17.14Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
17.14Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
17.14Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
17.14Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
17.14Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
17.14Single6TQ7SB-3348676TQ7-OX1-SB-334867
17.14Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
17.14Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
17.14Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
17.14Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
17.14Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
17.14Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
17.14Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
17.14Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.14Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.14Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
17.14Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
17.14Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
17.14Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
17.14Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
17.14Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
17.14Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
17.14Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
17.14Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
17.14Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
17.14Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
17.14Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
17.14Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
17.14Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
17.14Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
17.14Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
17.14Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
17.14Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
17.14Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
17.14Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
17.14Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
17.14Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
17.14Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
17.14Consensuslpa_onOrthosteric Ligandlpa1_on
17.14Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
17.14Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
17.14Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
17.14Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
17.07Single6JODAngiotensin II6JOD-AT2-Angiotensin II
17.07Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
17.07Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
17.07Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
17.07Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
17.07Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
17.07Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
17.07Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
17.07Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
17.07Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
17.07Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
17.07Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
17.07Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
17.07Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
17.07Consensusvasop-oxy_onOrthosteric Ligandv2_on
17.07Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
16.67Single3OE6IT1t3OE6-CXCR4-IT1t
16.67Single4N4WSANT-14N4W-SMO-SANT-1
16.67Single4RWADIPP-NH24RWA-δ-DIPP-NH2
16.67Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
16.67Single5CXVTiotropium5CXV-M1-Tiotropium
16.67Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
16.67Single5X33BIIL2605X33-BLT1-BIIL260
16.67Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
16.67Single6CM4Risperidone6CM4-D2-Risperidone
16.67Single6IIURamatroban6IIU-TP-Ramatroban
16.67Single6OS2TRV0266OS2-AT1-TRV026
16.67Single6ZG4HTL00099366ZG4-M1-HTL0009936
16.67Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
16.67Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
16.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
16.67Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
16.67Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
16.67Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
16.67Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
16.67Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
16.67Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
16.67Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.67Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
16.67Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
16.67Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
16.67Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
16.67Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
16.67Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
16.67Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
16.67Single8XYIVUF106618XYI-CXCR3-VUF10661
16.67Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
16.67Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
16.67Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
16.67Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
16.67Consensusalpha1_offOrthosteric Ligandalpha1a_off
16.67Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
16.67Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
16.67Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
16.67Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
16.67Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
16.67Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
16.67Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
16.67Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
16.67Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
16.67Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
16.22Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
16.22Single5CGDHTL142425CGD-mGlu5-HTL14242
16.22Single6K1QIRL25006K1Q-ETB-IRL2500
16.22Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
16.22Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
16.22Single7EZCUKA7EZC-A2A-UKA
16.22Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
16.22Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
16.22Single7UM4AS26747237UM4-5-HT5A-AS2674723
16.22Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
16.22Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.22Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
16.22Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
16.22Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
16.22Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
16.22Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
16.22Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
16.22Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
16.22Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
16.22Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
16.22Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
16.22Single8XVUCXCL28XVU-CXCR2-CXCL2
16.22Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
16.22Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
16.22Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
16.22Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
16.22Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
16.22Consensusprostanoid_offOrthosteric Ligandep_off dp_off
16.13Single3OE9IT1t3OE9-CXCR4-IT1t
16.13Single6LI0C176LI0-GPR52-C17
16.13Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
16.13Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
16.13Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
16.13Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.13Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
16.13Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
16.13Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
16.13Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.13Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
16.13Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
16.13Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
16.13Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
16.13Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
16.13Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
16.13Single9B9Y7DY9B9Y-CB1-7DY
16.13Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
16.13Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
15.91Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
15.79Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
15.79Single5WF6UK-4320975WF6-A2A-UK-432097
15.79Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
15.79Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
15.79Single6PT3DPI-2876PT3-δ-DPI-287
15.79Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
15.79Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
15.79Single8IEIA1LYA8IEI-GPR156-A1LYA
15.79Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
15.79Single8X5YAstemizole8X5Y-H1-Astemizole
15.79Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
15.79Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
15.79Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
15.79Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
15.62Single3ODUIT1t3ODU-CXCR4-IT1t
15.62Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
15.62Single4S0VSuvorexant4S0V-OX2-Suvorexant
15.62Single5ZKQABT-4915ZKQ-PAF-ABT-491
15.62Single6AKXA4R6AKX-CCR5-A4R
15.62Single6AKYMaraviroc6AKY-CCR5-Maraviroc
15.62Single6B73MP11046B73-κ-MP1104
15.62Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
15.62Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
15.62Single6TPJSuvorexant6TPJ-OX2-Suvorexant
15.62Single7BR3Elagolix7BR3-GnRH1-Elagolix
15.62Single7F8YDevazepide7F8Y-CCKA-Devazepide
15.62Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
15.62Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
15.62Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
15.62Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.62Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
15.62Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
15.62Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
15.62Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
15.62Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
15.62Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
15.62Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.62Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.62Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
15.62Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
15.62Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
15.62Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
15.62Single8IWESpermidine8IWE-TA9-Spermidine
15.62Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
15.62Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
15.62Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
15.62Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
15.62Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
15.62Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
15.62Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
15.62Single9BA0A1AKN9BA0-CB1-A1AKN
15.62Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
15.62Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
15.62Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
15.62Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
15.62Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
15.62Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
15.62Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
15.62Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
15.62Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
15.62Consensusorexin_offOrthosteric Ligandox2_off ox1_off
15.62Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
15.62Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
15.56Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
15.56Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
15.56Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
15.56Consensusbradykinin_onOrthosteric Ligandbk2_on
15.56Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
15.56Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
15.56Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
15.38Single7F8XNN90567F8X-CCKA-NN9056
15.38Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
15.38Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
15.38Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
15.38Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
15.38Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
15.38Single8IEPA1LYA8IEP-GPR156-A1LYA
15.38Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
15.38Single8KIGSHU91198KIG-MC3-SHU9119-Ca
15.38Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
15.38Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.38Single8XWNCXCL88XWN-CXCR2-CXCL8
15.38Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
15.38Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
15.38Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
15.15Single2YDOAdenosine2YDO-A2A-Adenosine
15.15Single4MBSMaraviroc4MBS-CCR5-Maraviroc
15.15Single4ZJCSB-6740424ZJC-OX1-SB-674042
15.15Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
15.15Single6TP3Nemorexant6TP3-OX1-Nemorexant
15.15Single6TPGEMPA6TPG-OX2-EMPA
15.15Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
15.15Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
15.15Single6ZG9GSK10347026ZG9-M1-GSK1034702
15.15Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
15.15Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
15.15Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
15.15Single7T32ZM-2413857T32-A2A-ZM-241385
15.15Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
15.15Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
15.15Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
15.15Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
15.15Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
15.15Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
15.15Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
15.15Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
15.15Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
15.15Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
15.15Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
15.15Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
15.15Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
15.15Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
15.15Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
15.15Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
15.15Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
15.15Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
15.15Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.15Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
15.15Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
15.15Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
15.15Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
15.15Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
15.15Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
15.15Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
15.15Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
15.15Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
15.15Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
15.15Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
15.15Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
15.15Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
15.15Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
15.15Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
15.00Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
15.00Single6HLOAprepitant6HLO-NK1-Aprepitant
15.00Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
15.00Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
15.00Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
15.00Single7SK5CXCL127SK5-ACKR3-CXCL12
15.00Single8IEBA1LYA8IEB-GPR156-A1LYA
15.00Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
15.00Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
15.00Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
14.71Single2Y04Salbutamol2Y04-β1-Salbutamol
14.71Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
14.71Single4MQSIperoxo4MQS-M2-Iperoxo
14.71Single4U14Tiotropium4U14-M3-Tiotropium
14.71Single5DHGC-355DHG-NOP-C-35
14.71Single5DHHSB-6121115DHH-NOP-SB-612111
14.71Single5DSGTiotropium5DSG-M4-Tiotropium
14.71Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
14.71Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
14.71Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
14.71Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
14.71Single6DRXLisuride6DRX-5-HT2B-Lisuride
14.71Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
14.71Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
14.71Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
14.71Single6GPSMK08126GPS-CCR2-MK0812
14.71Single6IIVDaltroban6IIV-TP-Daltroban
14.71Single6PS1Timolol6PS1-β2-Timolol
14.71Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
14.71Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
14.71Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
14.71Single7F83PF-051904577F83-Ghrelin-PF-05190457
14.71Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
14.71Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
14.71Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
14.71Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
14.71Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
14.71Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
14.71Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
14.71Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
14.71Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
14.71Single7UL4Alvimopan7UL4-μ-Alvimopan
14.71Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
14.71Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
14.71Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
14.71Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
14.71Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
14.71Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
14.71Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
14.71Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
14.71Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
14.71Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
14.71Single8JXRLSD8JXR-D1-LSD
14.71Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
14.71Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
14.71Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
14.71Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
14.71Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
14.71Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.71Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.71Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.71Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
14.71Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
14.71Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
14.71Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
14.71Single8X63Mepyramine8X63-H1-Mepyramine
14.71Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
14.71Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
14.71Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
14.71Single9CHXS-Carazolol9CHX-β2-S-Carazolol
14.71Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
14.71Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
14.71Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
14.71Consensusa3_onOrthosteric Liganda3a_on
14.71Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
14.71Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
14.71Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
14.71Consensusblt_onOrthosteric Ligandblt1_on
14.71Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
14.71Consensuscck_offOrthosteric Ligandccka_off
14.71Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
14.71Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
14.71Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
14.71Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
14.71Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
14.71Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
14.71Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
14.71Consensushistamine_offOrthosteric Ligandh1_off
14.71Consensusleukotriene_onOrthosteric Ligandblt_on
14.71Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
14.71Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
14.71Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
14.71Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
14.71Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
14.71Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
14.71Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
14.63Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
14.63Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.63Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
14.63Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
14.63Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
14.29Single2Y03Isoprenaline2Y03-β1-Isoprenaline
14.29Single4JKVTaladegib4JKV-SMO-Taladegib
14.29Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
14.29Single5CGCHTL142425CGC-mGlu5-HTL14242
14.29Single5JQHS-Carazolol5JQH-β2-S-Carazolol
14.29Single5N2RPSB-365N2R-A2A-PSB-36-Na
14.29Single5N2SPSB365N2S-A1-PSB36
14.29Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
14.29Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
14.29Single5TVNLSD5TVN-5-HT2B-LSD
14.29Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
14.29Single5WQCEMPA5WQC-OX2-EMPA
14.29Single5XPRBosentan5XPR-ETB-Bosentan
14.29Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
14.29Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
14.29Single6D26Fevipiprant6D26-DP2-Fevipiprant
14.29Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
14.29Single6GPXMK08126GPX-CCR2-MK0812
14.29Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
14.29Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
14.29Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
14.29Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
14.29Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
14.29Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
14.29Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
14.29Single6PS6Timolol6PS6-β2-Timolol
14.29Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
14.29Single7C61Ergotamine7C61-5-HT1B-Ergotamine
14.29Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
14.29Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
14.29Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
14.29Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
14.29Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
14.29Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
14.29Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
14.29Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
14.29Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
14.29Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
14.29Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
14.29Single8QOTNanobody-E8QOT-μ-Nanobody-E
14.29Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
14.29Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
14.29Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
14.29Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
14.29Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
14.29Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
14.29Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
14.29Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
14.29Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
14.29Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
14.29Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
14.29Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
14.29Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
14.29Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
14.29Consensusa3_on_gpOrthosteric Liganda3a_on_gp
14.29Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
14.29Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
14.29Consensusadenosine_offOrthosteric Liganda1_off a2_off
14.29Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
14.29Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
14.29Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
14.29Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
14.29Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
14.29Consensusdp_offOrthosteric Liganddp2_off
14.29Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
14.29Consensusep_offOrthosteric Ligandep4_off
14.29Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
14.29Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
14.29Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
14.29Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
14.29Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
14.29Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
14.29Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Consensustrace-amine_onOrthosteric Ligandta1_on
13.95Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
13.95Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
13.95Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
13.95Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
13.89Single3P0GBI1671073P0G-β2-BI167107
13.89Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
13.89Single4U15Tiotropium4U15-M3-Tiotropium
13.89Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
13.89Single5V54Methiothepin5V54-5-HT1B-Methiothepin
13.89Single5V56TC1145V56-SMO-TC114
13.89Single5V57TC1145V57-SMO-TC114
13.89Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
13.89Single6H7JIsoprenaline6H7J-β1-Isoprenaline
13.89Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
13.89Single6OL9Tiotropium6OL9-M5-Tiotropium
13.89Single6OS1TRV0266OS1-AT1-TRV026
13.89Single6WGTLSD6WGT-5-HT2A-LSD
13.89Single7B6WCyclazosin7B6W-α1b-Cyclazosin
13.89Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
13.89Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
13.89Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
13.89Single7P2L4YI7P2L-mGlu5-4YI
13.89Single7TUYGSK682753A7TUY-GPR183-GSK682753A
13.89Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
13.89Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
13.89Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
13.89Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
13.89Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
13.89Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
13.89Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
13.89Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
13.89Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
13.89Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
13.89Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
13.89Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
13.89Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
13.89Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
13.89Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
13.89Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
13.89Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
13.89Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
13.89Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
13.89Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
13.89Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
13.89Consensus5ht1_offOrthosteric Ligand5ht1b_off
13.89Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
13.89Consensusa2_onOrthosteric Liganda2b_on
13.89Consensusa2_on_gpOrthosteric Liganda2b_on_gp
13.89Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
13.89Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
13.89Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
13.89Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
13.89Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
13.89Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
13.89Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
13.89Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
13.89Consensusrelaxin_onOrthosteric Ligandrxfp4_on
13.89Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
13.89Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.89Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
13.79Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
13.79Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
13.64Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
13.51Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
13.51Single4LDEBI1671074LDE-β2-BI167107
13.51Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
13.51Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
13.51Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
13.51Single6MXTSalmeterol6MXT-β2-Salmeterol
13.51Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
13.51Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
13.51Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
13.51Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
13.51Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
13.51Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
13.51Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
13.51Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.51Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.51Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
13.51Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
13.51Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
13.51Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
13.51Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
13.51Single8JJ8Formoterol8JJ8-β2-Formoterol
13.51Single8JJLOlodaterol8JJL-β2-Olodaterol
13.51Single8JWY2-1188JWY-A2A-2-118
13.51Single8JWZAB9288JWZ-A2A-AB928-Na
13.51Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
13.51Single8XWMCXCL68XWM-CXCR2-CXCL6
13.51Single8XWSCXCL58XWS-CXCR2-CXCL5
13.51Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
13.51Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
13.51Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
13.51Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
13.51Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
13.51Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
13.51Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
13.51Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
13.51Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.51Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.33Single3OE8IT1t3OE8-CXCR4-IT1t
13.33Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.33Single9CHUNoradrenaline9CHU-β2-Noradrenaline
13.16Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
13.16Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
13.16Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
13.16Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
13.16Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
13.16Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
13.16Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
13.16Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.16Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
13.16Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
13.16Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
13.16Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.16Single8XVJMacitentan8XVJ-ETA-Macitentan
13.16Single8XWFCXCL38XWF-CXCR2-CXCL3
13.16Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
13.16Consensuschemerin_onOrthosteric Ligandcml1_on
12.90Single4XNWMRS25004XNW-P2Y1-MRS2500
12.90Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
12.90Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
12.90Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
12.90Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.90Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
12.90Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
12.90Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
12.90Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
12.90Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
12.90Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
12.90Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
12.90Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
12.90Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
12.90Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
12.90Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
12.90Consensus5ht2_onOrthosteric Ligand5ht2b_on
12.90Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.90Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
12.82Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
12.82Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
12.82Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
12.82Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
12.82Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
12.82Single7XN9L-054,5227XN9-SST2-L-054,522
12.82Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
12.82Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
12.82Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
12.82Consensuskisspeptin_onOrthosteric Ligandkiss1_on
12.82Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
12.82Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
12.82Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
12.50Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
12.50Single4IARErgotamine4IAR-5-HT1B-Ergotamine
12.50Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
12.50Single5L7IVismodegib5L7I-SMO-Vismodegib
12.50Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
12.50Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
12.50Single7SRQLSD7SRQ-5-HT2B-LSD
12.50Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
12.50Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
12.50Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
12.50Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
12.50Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
12.50Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
12.50Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
12.50Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
12.50Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
12.50Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
12.50Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
12.50Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
12.50Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
12.50Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
12.50Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
12.50Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
12.50Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
12.50Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
12.50Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
12.50Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
12.50Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
12.50Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
12.50Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
12.50Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
12.50Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
12.50Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
12.50Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
12.50Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
12.20Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
12.12Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
12.12Single3PWHZM-2413853PWH-A2A-ZM-241385
12.12Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
12.12Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
12.12Single5WS3EMPA5WS3-OX2-EMPA
12.12Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
12.12Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
12.12Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
12.12Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
12.12Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
12.12Single6TODEMPA6TOD-OX1-EMPA-Na
12.12Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
12.12Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
12.12Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
12.12Single7F8ULintitript7F8U-CCKA-Lintitript
12.12Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
12.12Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
12.12Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.12Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
12.12Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
12.12Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
12.12Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
12.12Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
12.12Single7XRRLemborexant7XRR-OX2-Lemborexant
12.12Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
12.12Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
12.12Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
12.12Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
12.12Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.12Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
12.12Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
12.12Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
12.12Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
12.12Single8GNGIstradefylline8GNG-A2A-Istradefylline
12.12Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
12.12Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
12.12Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
12.12Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
12.12Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
12.12Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
12.12Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
12.12Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.12Consensusalpha2_offOrthosteric Ligandalpha2c_off
12.12Consensusangiotensin_offOrthosteric Ligandat1_off
12.12Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
12.12Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
12.12Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
12.12Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
12.12Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
12.12Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
12.12Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
11.90Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
11.90Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
11.90Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
11.90Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
11.76Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
11.76Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
11.76Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
11.76Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
11.76Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
11.76Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
11.76Single5IU7Q274563465IU7-A2A-Q27456346-Na
11.76Single5IUBQ274563445IUB-A2A-Q27456344-Na
11.76Single5JTBZM-2413855JTB-A2A-ZM-241385
11.76Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
11.76Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
11.76Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
11.76Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
11.76Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
11.76Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
11.76Single6IQLL7458706IQL-D4-L745870
11.76Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
11.76Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
11.76Single6PS0S-Carazolol6PS0-β2-S-Carazolol
11.76Single6PS4ICI118-5516PS4-β2-ICI118-551
11.76Single6PS5S-Propranolol6PS5-β2-S-Propranolol
11.76Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
11.76Single6TPNHTL66416TPN-OX2-HTL6641
11.76Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
11.76Single6V9SGTPL114036V9S-OX1-GTPL11403
11.76Single6VI4JDTic6VI4-κ-JDTic
11.76Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
11.76Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
11.76Single7AROLUF58337ARO-A2A-LUF5833-Na
11.76Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
11.76Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
11.76Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
11.76Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
11.76Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
11.76Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
11.76Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
11.76Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
11.76Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76Single7UL3Famotidine7UL3-H2-Famotidine
11.76Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
11.76Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
11.76Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
11.76Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
11.76Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
11.76Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
11.76Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
11.76Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
11.76Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
11.76Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.76Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.76Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
11.76Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
11.76Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
11.76Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
11.76Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
11.76Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
11.76Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
11.76Single8K2WAMG4878K2W-CXCR3-AMG487
11.76Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.76Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
11.76Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
11.76Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.76Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.76Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
11.76Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
11.76Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
11.76Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
11.76Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
11.76Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
11.76Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
11.76Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
11.76Consensusa2_offOrthosteric Liganda2a_off
11.76Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
11.76Consensusalpha1_onOrthosteric Ligandalpha1a_on
11.76Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
11.76Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
11.76Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
11.76Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
11.76Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
11.76Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
11.76Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
11.76Consensusopsins_offOrthosteric Ligandrhodopsin_off
11.76Consensussensory_offOrthosteric Ligandopsins_off
11.43Single3EMLZM-2413853EML-A2A-ZM-241385
11.43Single3NY8ICI118-5513NY8-β2-ICI118-551
11.43Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
11.43Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
11.43Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
11.43Single4EJ4Naltrindole4EJ4-δ-Naltrindole
11.43Single4GBRS-Carazolol4GBR-β2-S-Carazolol
11.43Single4QIMANTA XV4QIM-SMO-ANTA XV
11.43Single4QKX35V4QKX-β2-35V
11.43Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
11.43Single5IU8Q274563475IU8-A2A-Q27456347-Na
11.43Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
11.43Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
11.43Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
11.43Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
11.43Single5UENDU1725UEN-A1-DU172
11.43Single5UIGCmpd-15UIG-A2A-Cmpd-1
11.43Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
11.43Single6D27CAY104716D27-DP2-CAY10471
11.43Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
11.43Single6H7MSalbutamol6H7M-β1-Salbutamol
11.43Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
11.43Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
11.43Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
11.43Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
11.43Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
11.43Single6S0LZM-2413856S0L-A2A-ZM-241385
11.43Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.43Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
11.43Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
11.43Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
11.43Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
11.43Single7PYRPSB-21157PYR-A2A-PSB-2115
11.43Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
11.43Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
11.43Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
11.43Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
11.43Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
11.43Single7WC7Lisuride7WC7-5-HT2A-Lisuride
11.43Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
11.43Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
11.43Single8CU6LJ-45178CU6-A2A-LJ-4517
11.43Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
11.43Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
11.43Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
11.43Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
11.43Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
11.43Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
11.43Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
11.43Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.43Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.43Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.43Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.43Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.43Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.43Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.43Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.43Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.43Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.43Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
11.43Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
11.43Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
11.43Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
11.43Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
11.43Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
11.43Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
11.43Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
11.43Single8JJOAlprenolol8JJO-β2-Alprenolol
11.43Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
11.43Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
11.43Single8RLNLUF58348RLN-A2A-LUF5834
11.43Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
11.43Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
11.43Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.43Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.43Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.43Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.43Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
11.43Single8X64Desloratadine8X64-H1-Desloratadine
11.43Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
11.43Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
11.43Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
11.43Consensus5ht5_onOrthosteric Ligand5ht5a_on
11.43Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
11.43Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
11.43Consensusalpha2_onOrthosteric Ligandalpha2b_on
11.43Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
11.43Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
11.43Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
11.43Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
11.43Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
11.43Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
11.43Consensusdopamine_offOrthosteric Ligandd2_off d3_off
11.43Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
11.43Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
11.43Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
11.36Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single2RH1S-Carazolol2RH1-β2-S-Carazolol
11.11Single2YCWS-Carazolol2YCW-β1-S-Carazolol
11.11Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
11.11Single5D6LS-Carazolol5D6L-β2-S-Carazolol
11.11Single5IUAQ274563485IUA-A2A-Q27456348-Na
11.11Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
11.11Single5WIUNemonapride5WIU-D4-Nemonapride
11.11Single5WIVNemonapride5WIV-D4-Nemonapride-Na
11.11Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
11.11Single6E67BI1671076E67-β2-BI167107-Gs (fused)
11.11Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
11.11Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
11.11Single6LUQHaloperidol6LUQ-D2-Haloperidol
11.11Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
11.11Single6S0QZM-2413856S0Q-A2A-ZM-241385
11.11Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
11.11Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
11.11Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
11.11Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
11.11Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
11.11Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
11.11Single7SINNPS-21437SIN-CaS-NPS-2143
11.11Single7SINNPS-21437SIN-CaS-NPS-2143
11.11Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
11.11Single7W41PD1762527W41-BB2-PD176252
11.11Single7WC6LSD7WC6-5-HT2A-LSD
11.11Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
11.11Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
11.11Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
11.11Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
11.11Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8GNEKW-63568GNE-A2A-KW-6356-Na
11.11Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
11.11Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
11.11Single8ZMFA1L108ZMF-5-HT2C-A1L10
11.11Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
11.11Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
11.11Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
11.11Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
11.11Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
11.11Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
11.11Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
11.11Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
11.11Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
11.11Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
11.11Consensusamine_offonOrthosteric Ligandamine_off amine_on
11.11Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
11.11Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
11.11Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
11.11Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
11.11Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
11.11Consensusbombesin_offOrthosteric Ligandbb2_off
11.11Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
11.11Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
11.11Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
11.11Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
11.11Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
10.81Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
10.81Single5D5AS-Carazolol5D5A-β2-S-Carazolol
10.81Single5D5BS-Carazolol5D5B-β2-S-Carazolol
10.81Single5TZRMK86665TZR-FFA1-MK8666
10.81Single6E59L-7607356E59-NK1-L-760735
10.81Single6J20Aprepitant6J20-NK1-Aprepitant
10.81Single6J21Aprepitant6J21-NK1-Aprepitant
10.81Single7F1TMIP-1a7F1T-CCR5-MIP-1a
10.81Single7PX4PSB-21137PX4-A2A-PSB-2113
10.81Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
10.81Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
10.81Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
10.81Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
10.81Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
10.81Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
10.81Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
10.81Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
10.81Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
10.81Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
10.81Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
10.81Single8XVLZibotentan8XVL-ETA-Zibotentan
10.81Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
10.81Single9BJKNAM9BJK-μ-Naloxone-NAM
10.81Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
10.81Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
10.81Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
10.81Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
10.81Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
10.81Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
10.81Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
10.81Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
10.81Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
10.53Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
10.53Single3D4STimolol3D4S-β2-Timolol
10.53Single4AMIBucindolol4AMI-β1-Bucindolol
10.53Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
10.53Single4PY02MeSATP4PY0-P2Y12-2MeSATP
10.53Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
10.53Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
10.53Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
10.53Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
10.53Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
10.53Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
10.53Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
10.53Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53Single8XWACXCL18XWA-CXCR2-CXCL1
10.53Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
10.53Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
10.53Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
10.53Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
10.53Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
10.34Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
10.34Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
10.26Single6H7LDobutamine6H7L-β1-Dobutamine
10.26Single6IBLArformoterol6IBL-β1-Arformoterol
10.26Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
10.26Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
10.26Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
10.26Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.26Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
10.26Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
10.26Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
10.26Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
10.00Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
10.00Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
10.00Single8HS2Fab0468HS2-GPR20-Fab046
10.00Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
10.00Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
10.00Single8XQJJN2418XQJ-Apelin-JN241
10.00Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
10.00Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
9.76Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
9.76Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
9.76Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
9.76Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
9.68Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
9.68Single6TQ9SB-4081246TQ9-OX1-SB-408124
9.68Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
9.68Single8A2OTheophylline8A2O-A2A-Theophylline-Na
9.68Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
9.68Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
9.68Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
9.68Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
9.68Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
9.68Consensusp2y_offOrthosteric Ligandp2y1_off
9.38Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
9.38Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
9.38Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
9.38Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
9.38Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
9.38Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
9.38Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
9.38Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
9.38Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
9.09Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
9.09Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
9.09Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
9.09Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
9.09Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
9.09Single4O9RCyclopamine4O9R-SMO-Cyclopamine
9.09Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
9.09Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
9.09Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
9.09Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
9.09Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
9.09Single7UL2SR486927UL2-NTS1-SR48692-Na
9.09Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
9.09Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
9.09Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
9.09Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
9.09Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
9.09Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
9.09Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
9.09Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
9.09Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
9.09Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
9.09Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
9.09Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.09Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.09Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
9.09Consensusgq_nucleotideOrthosteric Ligandgq_p2y
9.09Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
9.09Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
9.09Consensusneurotensin_offOrthosteric Ligandnts1_off
9.09Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
8.82Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
8.82Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
8.82Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
8.82Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
8.82Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
8.82Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
8.82Single4QINSAG1.54QIN-SMO-SAG1.5
8.82Single6DS0Ly2660976DS0-5-HT2B-Ly266097
8.82Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
8.82Single6ME2Ramelteon6ME2-MT1-Ramelteon
8.82Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
8.82Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
8.82Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
8.82Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
8.82Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
8.82Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
8.82Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
8.82Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
8.82Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
8.82Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
8.82Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
8.82Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
8.82Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.82Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
8.82Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
8.82Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
8.82Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.82Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
8.82Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
8.82Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
8.82Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
8.82Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.82Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.82Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.82Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
8.82Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
8.82Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
8.82Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
8.82Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
8.82Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
8.82Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
8.82Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
8.82Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
8.82Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
8.82Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
8.57Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
8.57Single3REYXAC3REY-A2A-XAC
8.57Single3RZECidoxepin3RZE-H1-Cidoxepin
8.57Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
8.57Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
8.57Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
8.57Single5UVIZM-2413855UVI-A2A-ZM-241385
8.57Single6A94Zotepine6A94-5-HT2A-Zotepine
8.57Single6AQFZM-2413856AQF-A2A-ZM-241385
8.57Single6FFIMMPEP6FFI-mGlu5-MMPEP
8.57Single6KUXRS-799486KUX-α2a-RS-79948
8.57Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
8.57Single6MH8ZM-2413856MH8-A2A-ZM-241385
8.57Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
8.57Single6TPKRetosiban6TPK-OT-Retosiban
8.57Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
8.57Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
8.57Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
8.57Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
8.57Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
8.57Single7VODCariprazine7VOD-5-HT2A-Cariprazine
8.57Single7VV6C48/807VV6-MRGPRX2-C48/80
8.57Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
8.57Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
8.57Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
8.57Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
8.57Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
8.57Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.57Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
8.57Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
8.57Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
8.57Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.57Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
8.57Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
8.57Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
8.57Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
8.57Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
8.57Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
8.57Single9BJKNaloxone9BJK-μ-Naloxone-NAM
8.57Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
8.57Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
8.57Consensusvasop-oxy_offOrthosteric Ligandot_off
8.33Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
8.33Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
8.33Single2Y01Dobutamine2Y01-β1-Dobutamine
8.33Single2Y02Carmoterol2Y02-β1-Carmoterol
8.33Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
8.33Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
8.33Single6FFHFenobam6FFH-mGlu5-Fenobam
8.33Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
8.33Single7BU7BI1671077BU7-β1-BI167107
8.33Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
8.33Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
8.33Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
8.33Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
8.33Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.33Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
8.33Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
8.33Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
8.33Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
8.33Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
8.33Single9IYAONO-97105319IYA-GPR55-ONO-9710531
8.33Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
8.33Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
8.33Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
8.11Single2Y00Dobutamine2Y00-β1-Dobutamine
8.11Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
8.11Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
8.11Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
8.11Single6Z4SSR486926Z4S-NTS1-SR48692
8.11Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.11Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.11Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
8.11Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
8.11Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
8.11Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
8.11Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
8.11Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
8.11Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
7.89Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
7.89Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
7.89Single7R0CAVP7R0C-V2-AVP-Arrestin2
7.89Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
7.89Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
7.89Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
7.89Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
7.89Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
7.89Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
7.89Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
7.69Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
7.69Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
7.69Single8XQJJN2418XQJ-Apelin-JN241
7.69Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
7.69Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
7.69Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
7.69Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
7.50Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
7.50Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
7.32Single6KNMJN241-96KNM-Apelin-JN241-9
7.32Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
7.32Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
7.32Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
7.32Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
7.32Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
6.98Single7SHEPI; PE7SHE-GPR158-PI; PE
6.98Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
6.67Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
6.45Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
6.45Single7WC4Serotonin7WC4-5-HT2A-Serotonin
6.45Single8PWNTheophylline8PWN-A2A-Theophylline
6.25Single3RFMCaffeine3RFM-A2A-Caffeine
6.25Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
6.25Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
6.25Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
6.25Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
6.06Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
6.06Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
6.06Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
6.06Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
6.06Single6ME5Agomelatine6ME5-MT1-Agomelatine
6.06Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
6.06Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
6.06Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
6.06Single7WC5Psilocin7WC5-5-HT2A-Psilocin
6.06Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.06Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
6.06Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
6.06Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
6.06Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
6.06Single8JPSCCL78JPS-ACKR1-CCL7
6.06Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
6.06Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
6.06Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
6.06Consensusgi_sensoryOrthosteric Ligandgi_opsins
6.06Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
6.06Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.88Single3PBLEticlopride3PBL-D3-Eticlopride
5.88Single6HLLCP999946HLL-NK1-CP99994
5.88Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
5.88Single6TP4ACT-4622066TP4-OX1-ACT-462206
5.88Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
5.88Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
5.88Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
5.71Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
5.71Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
5.71Single6ME9Ramelteon6ME9-MT2-Ramelteon
5.71Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
5.71Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
5.71Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
5.71Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
5.71Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
5.71Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
5.56Single6ZINSR486926ZIN-NTS1-SR48692
5.56Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
5.56Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
5.56Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
5.41Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
5.26Single4NTJAZD12834NTJ-P2Y12-AZD1283
5.26Single6HLPNetupitant6HLP-NK1-Netupitant
5.26Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
5.13Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
5.13Consensustachykinin_offOrthosteric Ligandnk1_off
5.00Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
4.88Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
4.88Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
4.55Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.57Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
3.57Single6D35Cholesterol6D35-SMO-Cholesterol
3.57Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
3.57Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
3.57Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
3.57Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
3.57Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
3.57Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
3.57Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
3.57Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
3.57Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
3.57Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
3.57Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.57Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.57Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.57Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
3.57Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
3.57Single7DTTCa7DTT-CaS-Ca-Ca
3.57Single7DTTCa7DTT-CaS-Ca-Ca
3.57Single7DTUTryptophan7DTU-CaS-Tryptophan
3.57Single7DTUTryptophan7DTU-CaS-Tryptophan
3.57Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
3.57Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
3.57Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
3.57Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
3.57Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.57Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.57Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.57Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.57Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
3.57Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
3.57Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
3.57Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
3.57Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
3.57Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
3.57Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
3.57Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
3.57Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
3.57Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
3.57Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
3.57Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
3.57Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
3.57Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
3.57Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
3.57Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
3.57Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
3.57Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.57Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.57Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.57Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
3.57Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
3.57Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
3.57Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
3.57Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
3.57Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
3.57Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
3.57Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.57Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.57Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.57Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
3.57Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.57Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.57Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.57Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
3.57Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
3.57Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
3.57Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
3.57Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
3.57Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
3.57Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
3.57Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
3.57Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
3.57Single7XW7K1-707XW7-TSH-K1-70
3.57Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
3.57Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
3.57Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
3.57Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
3.57Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
3.57Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
3.57Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
3.57Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
3.57Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
3.57Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
3.57Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
3.57Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
3.57Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
3.57Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
3.57Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
3.57Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
3.57Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
3.57Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
3.57Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
3.57Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
3.57Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
3.57Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
3.57Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
3.57Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
3.57Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
3.57Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
3.57Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
3.57Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
3.57Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
3.57Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
3.57Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
3.57Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
3.57Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
3.57Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
3.57Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
3.57Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
3.57Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
3.57Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
3.57Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
3.57Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
3.57Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
3.57Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
3.57Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
3.57Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
3.57Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
3.57Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
3.57Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
3.57Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
3.57Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
3.57Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
3.57Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
3.57Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
3.57Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
3.57Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
3.57Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
3.57Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
3.57Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
3.57Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
3.57Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.57Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.57Single8WVXNorrin8WVX-LGR4-Norrin
3.57Single8WVYNorrin8WVY-LGR4-Norrin
3.57Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
3.57Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
3.57Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
3.57Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
3.57Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
3.57Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
3.57Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
3.57Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
3.57Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
3.57Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
3.57Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
3.57Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
3.57Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
3.57Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
3.57Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
3.57Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
3.57Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
3.57Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
3.57Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
3.57Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
3.57Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
3.57Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
3.57Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
3.57Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
3.57Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
3.57Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
3.57Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
3.57Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
3.57Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
3.57Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
3.57Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
3.57Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
3.57Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
3.57Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
3.57Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
3.45Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.45Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.45Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.45Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
3.45Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.45Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.45Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.45Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
3.45Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.45Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
3.45Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
3.45Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
3.45Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
3.45Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
3.33Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
3.33Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
3.33Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
3.33Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
3.23Single5MZPCaffeine5MZP-A2A-Caffeine-Na
3.23Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
3.23Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
3.23Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
3.23Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
3.23Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
3.23Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23Single9IVMLSN33188399IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
3.12Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
3.12Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
3.12Single5L7DCholesterol5L7D-SMO-Cholesterol
3.12Single6VCBLSN31604406VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
3.12Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
3.12Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
3.12Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
3.12Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
3.03Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
3.03Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
3.03Consensussensory_onOrthosteric Ligandopsins_on
2.94Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
2.94Single3UZAGTPL92363UZA-A2A-GTPL9236
2.94Single8ZPLCholesterol8ZPL-CXCR4-HF51116-Cholesterol
2.94Single8ZPMCholesterol8ZPM-CXCR4-AMD070-Cholesterol
2.94Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
2.94Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
2.94Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
2.86Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
2.86Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
2.86Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
2.86Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
2.86Single8HNNSCH5467388HNN-CXCR3-SCH546738
2.78Single4K5YCP-3763954K5Y-CRF1-CP-376395
2.78Single4XNVBPTU4XNV-P2Y1-BPTU
2.78Single6C1QNDT95137276C1Q-C5a1-PMX53-NDT9513727
2.70Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
2.70Single8IYXYL-3658IYX-GPR34-YL-365
2.63Single4Z9GCP-3763954Z9G-CRF1-CP-376395
2.63Single8GTIBMK-C2058GTI-CRF1-BMK-C205
2.56Single8GTGBMK-I1528GTG-CRF1-BMK-I152
2.56Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
2.44Single7SHEPI; PE7SHE-GPR158-PI; PE
2.44Single8GTMBMK-C2038GTM-CRF1-BMK-C203
2.38Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
2.27Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
2.27Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
2.17Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
2.17Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
2.13Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
2.00Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3

PDB Summary
PDB 9JR3
Class B1
SubFamily Peptide
Type Parathyroid Hormone
SubType PTH1
Species Homo Sapiens
Ligand PTH
Other Ligand(s) -
Protein Partners chim(NtGi1L-Gs-CtGq)/Beta1/Gamma2
PDB Resolution 2.8
Date 2024-10-16
D.O.I. To be published
Net Summary
Imin 2.79
Number of Linked Nodes 947
Number of Links 1263
Number of Hubs 256
Number of Links mediated by Hubs 871
Number of Communities 28
Number of Nodes involved in Communities 376
Number of Links involved in Communities 595
Path Summary
Number Of Nodes in MetaPath 126
Number Of Links MetaPath 125
Number of Shortest Paths 1809678
Length Of Smallest Path 3
Average Path Length 29.3822
Length of Longest Path 69
Minimum Path Strength 1.28
Average Path Strength 6.54611
Maximum Path Strength 31.32
Minimum Path Correlation 0.7
Average Path Correlation 0.990295
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.7027
Average % Of Corr. Nodes 57.0685
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 57.1611
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• parathyroid hormone receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • type 1 parathyroid hormone receptor binding   • molecular transducer activity   • molecular function activator activity   • signaling receptor activity   • molecular function regulator activity   • signaling receptor regulator activity   • receptor ligand activity   • signaling receptor activator activity   • peptide hormone receptor binding   • hormone receptor binding   • hormone activity   • response to stimulus   • response to chemical   • response to xenobiotic stimulus   • response to parathyroid hormone   • response to hormone   • response to endogenous stimulus   • magnesium ion homeostasis   • inorganic ion homeostasis   • chemical homeostasis   • homeostatic process   • monoatomic ion homeostasis   • monoatomic cation homeostasis   • developmental process   • multicellular organismal process
Gene OntologyBiological Process• response to stimulus   • response to chemical   • response to xenobiotic stimulus   • response to parathyroid hormone   • response to hormone   • response to endogenous stimulus   • magnesium ion homeostasis   • inorganic ion homeostasis   • chemical homeostasis   • homeostatic process   • monoatomic ion homeostasis   • monoatomic cation homeostasis   • developmental process   • multicellular organismal process   • ossification   • bone mineralization   • animal organ development   • anatomical structure development   • biomineral tissue development   • tissue development   • multicellular organismal-level homeostasis   • homeostasis of number of cells within a tissue   • anatomical structure homeostasis   • tissue homeostasis   • homeostasis of number of cells   • biosynthetic process   • metabolic process   • cellular process   • macromolecule metabolic process   • macromolecule biosynthetic process   • multicellular organism development   • skeletal system development   • system development   • regulation of biosynthetic process   • regulation of biological process   • regulation of cellular process   • biological regulation   • positive regulation of biological process   • regulation of macromolecule metabolic process   • gene expression   • positive regulation of macromolecule biosynthetic process   • regulation of gene expression   • positive regulation of metabolic process   • positive regulation of gene expression   • positive regulation of biosynthetic process   • regulation of macromolecule biosynthetic process   • positive regulation of macromolecule metabolic process   • regulation of metabolic process   • positive regulation of cellular process   • RNA metabolic process   • primary metabolic process   • nucleobase-containing compound biosynthetic process   • nucleic acid metabolic process   • RNA biosynthetic process   • nucleobase-containing compound metabolic process   • DNA-templated transcription   • nucleic acid biosynthetic process   • transcription by RNA polymerase II   • negative regulation of apoptotic process in bone marrow cell   • negative regulation of programmed cell death   • apoptotic process in bone marrow cell   • regulation of apoptotic process in bone marrow cell   • regulation of apoptotic process   • negative regulation of biological process   • regulation of programmed cell death   • cell death   • negative regulation of apoptotic process   • negative regulation of cellular process   • apoptotic process   • programmed cell death   • regulation of generation of precursor metabolites and energy   • regulation of primary metabolic process   • positive regulation of glycogen metabolic process   • regulation of small molecule metabolic process   • small molecule metabolic process   • carbohydrate biosynthetic process   • hexose metabolic process   • positive regulation of glucose metabolic process   • positive regulation of glycogen biosynthetic process   • energy reserve metabolic process   • positive regulation of carbohydrate metabolic process   • regulation of glycogen metabolic process   • monosaccharide metabolic process   • regulation of glycogen biosynthetic process   • glucan biosynthetic process   • energy derivation by oxidation of organic compounds   • regulation of glucan biosynthetic process   • regulation of polysaccharide metabolic process   • polysaccharide metabolic process   • glucan metabolic process   • regulation of carbohydrate metabolic process   • regulation of glucose metabolic process   • carbohydrate metabolic process   • polysaccharide biosynthetic process   • glycogen metabolic process   • generation of precursor metabolites and energy   • glycogen biosynthetic process   • regulation of polysaccharide biosynthetic process   • regulation of carbohydrate biosynthetic process   • positive regulation of small molecule metabolic process   • glucose metabolic process   • phosphate ion homeostasis   • signaling   • cell-cell signaling   • cell communication   • intracellular calcium ion homeostasis   • calcium ion homeostasis   • cellular homeostasis   • intracellular monoatomic cation homeostasis   • intracellular chemical homeostasis   • intracellular monoatomic ion homeostasis   • regulation of developmental process   • regulation of biomineral tissue development   • regulation of bone mineralization   • positive regulation of ossification   • positive regulation of developmental process   • positive regulation of biomineral tissue development   • regulation of multicellular organismal process   • regulation of multicellular organismal development   • positive regulation of bone mineralization   • positive regulation of multicellular organismal process   • regulation of ossification   • response to alcohol   • response to oxygen-containing compound   • response to ethanol   • cellular response to stimulus   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • response to metal ion   • response to lead ion   • cell population proliferation   • positive regulation of cell population proliferation   • positive regulation of cell proliferation in bone marrow   • cell proliferation in bone marrow   • regulation of cell proliferation in bone marrow   • regulation of cell population proliferation   • response to nutrient levels   • response to vitamin D   • response to lipid   • response to nutrient   • response to vitamin   • hormone-mediated signaling pathway   • apoptotic signaling pathway   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • hormone-mediated apoptotic signaling pathway   • cellular response to hormone stimulus   • nucleoside phosphate metabolic process   • ribose phosphate metabolic process   • cAMP metabolic process   • cyclic purine nucleotide metabolic process   • carbohydrate derivative metabolic process   • nucleotide metabolic process   • cyclic nucleotide metabolic process   • purine-containing compound metabolic process   • purine nucleotide metabolic process   • ribonucleotide metabolic process   • organophosphate metabolic process   • nucleobase-containing small molecule metabolic process   • phosphate-containing compound metabolic process   • purine ribonucleotide metabolic process   • phosphorus metabolic process   • regulation of cartilage development   • regulation of chondrocyte differentiation   • connective tissue development   • cellular developmental process   • negative regulation of cartilage development   • negative regulation of chondrocyte differentiation   • regulation of cell differentiation   • cell differentiation   • negative regulation of cell differentiation   • negative regulation of developmental process   • chondrocyte differentiation   • negative regulation of multicellular organismal process   • cartilage development   • negative regulation of metabolic process   • negative regulation of gene expression   • negative regulation of biosynthetic process   • negative regulation of macromolecule biosynthetic process   • negative regulation of macromolecule metabolic process   • regulation of localization   • hexose transmembrane transport   • D-glucose import   • transport   • carbohydrate transport   • positive regulation of D-glucose transmembrane transport   • localization   • positive regulation of transmembrane transport   • regulation of D-glucose import   • positive regulation of D-glucose import   • regulation of transport   • establishment of localization   • transmembrane transport   • regulation of transmembrane transport   • positive regulation of transport   • D-glucose transmembrane transport   • regulation of D-glucose transmembrane transport   • monosaccharide transmembrane transport   • carbohydrate transmembrane transport   • positive regulation of cell communication   • regulation of signaling   • positive regulation of signal transduction   • regulation of signal transduction   • positive regulation of response to stimulus   • regulation of response to stimulus   • regulation of cell communication   • positive regulation of signaling   • response to cadmium ion   • small GTPase-mediated signal transduction   • Rho protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • regulation of leukocyte proliferation   • osteoclast proliferation   • regulation of osteoclast proliferation   • positive regulation of osteoclast proliferation   • leukocyte proliferation   • positive regulation of leukocyte proliferation   • bone maturation   • regulation of bone mineralization involved in bone maturation   • negative regulation of biomineral tissue development   • negative regulation of bone mineralization   • ossification involved in bone maturation   • bone development   • bone mineralization involved in bone maturation   • developmental maturation   • negative regulation of bone mineralization involved in bone maturation   • negative regulation of ossification   • anatomical structure maturation   • animal organ maturation   • positive regulation of DNA-templated transcription   • regulation of RNA metabolic process   • regulation of nucleobase-containing compound metabolic process   • regulation of RNA biosynthetic process   • regulation of transcription by RNA polymerase II   • positive regulation of nucleobase-containing compound metabolic process   • positive regulation of transcription by RNA polymerase II   • positive regulation of RNA metabolic process   • positive regulation of RNA biosynthetic process   • regulation of DNA-templated transcription   • regulation of inositol phosphate biosynthetic process   • alcohol metabolic process   • positive regulation of phosphate metabolic process   • inositol phosphate metabolic process   • regulation of phosphate metabolic process   • polyol biosynthetic process   • polyol metabolic process   • positive regulation of phosphorus metabolic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • positive regulation of inositol phosphate biosynthetic process   • organophosphate biosynthetic process   • inositol phosphate biosynthetic process   • alcohol biosynthetic process   • regulation of phosphorus metabolic process   • positive regulation of alcohol biosynthetic process   • tissue remodeling   • bone remodeling   • bone resorption   • response to fibroblast growth factor   • response to growth factor   • cellular anatomical structure   • extracellular region   • extracellular space   • binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • enzyme regulator activity   • molecular function activator activity   • phosphorus-oxygen lyase activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • adenylate cyclase activator activity   • adenylate cyclase activity   • cation binding   • metal ion binding   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • hair follicle placode formation   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • cellular response to nitrogen compound   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to nitrogen compound   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • cognition   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • adaptive thermogenesis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • protein localization   • establishment of protein localization   • nitrogen compound transport   • cellular macromolecule localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • protein secretion   • regulation of protein secretion   • regulation of secretion   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • regulation of protein transport   • peptide transport   • protein transport   • regulation of cellular localization   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • organelle   • vesicle   • extracellular membrane-bounded organelle   • intracellular anatomical structure   • cytoplasm   • cytosol   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • trans-Golgi network   • organelle membrane   • cytoskeletal protein binding   • spectrin binding   • enzyme binding   • GTPase binding   • phosphoric ester hydrolase activity   • alkylglycerophosphoethanolamine phosphodiesterase activity   • hydrolase activity, acting on ester bonds   • phosphoric diester hydrolase activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • positive regulation of cytosolic calcium ion concentration   • sensory perception of taste   • sensory organ development   • eye development   • retina development in camera-type eye   • visual system development   • camera-type eye development   • sensory system development   • response to decreased oxygen levels   • cellular response to oxygen levels   • cellular response to hypoxia   • cellular response to decreased oxygen levels   • cellular response to stress   • response to hypoxia   • response to oxygen levels   • response to abiotic stimulus   • phospholipase C-activating G protein-coupled receptor signaling pathway   • muscle cell apoptotic process   • striated muscle cell apoptotic process   • cardiac muscle cell apoptotic process   • photoreceptor inner segment   • somatodendritic compartment   • cell projection   • dendrite   • dendritic tree   • neuron projection   • plasma membrane bounded cell projection   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • photoreceptor outer segment   • photoreceptor cell cilium   • ciliary membrane   • photoreceptor outer segment membrane   • bounding membrane of organelle   • plasma membrane region   • cell projection membrane   • synapse   • cell junction   • cell body   • identical protein binding   • protein homodimerization activity   • protein dimerization activity   • amide binding   • peptide hormone binding   • hormone binding   • peptide receptor activity   • molecular transducer activity   • G protein-coupled receptor activity   • G protein-coupled peptide receptor activity   • signaling receptor activity   • transmembrane signaling receptor activity   • parathyroid hormone receptor activity   • osteoblast development   • cell development   • osteoblast differentiation   • embryo development ending in birth or egg hatching   • chordate embryonic development   • embryo development   • in utero embryonic development   • cell maturation   • cell surface receptor signaling pathway   • negative regulation of cell population proliferation   • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger   • apical part of cell   • apical plasma membrane   • basal part of cell   • basal plasma membrane   • basolateral plasma membrane   • receptor complex   • nucleus   • G-protein beta-subunit binding
Gene OntologyCellular Component
SCOP2Domain Identifier• G protein-coupled receptor-like
SCOP2Family Identifier• G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeNAG
PDB ResiduesH:H:?1 H:H:?2
Environment DetailsOpen EMBL-EBI Page
CodeNAG
NameN-Acetylglucosamine
SynonymsN-Acetylchitosamine
Identifier
FormulaC8 H15 N O6
Molecular Weight221.208
SMILES
PubChem24139
Formal Charge0
Total Atoms30
Total Chiral Atoms5
Total Bonds30
Total Aromatic Bonds0

CodeNH2
PDB ResiduesL:L:?35
Environment DetailsOpen EMBL-EBI Page
CodeNH2
NameAMINO GROUP
Synonyms
Identifier
FormulaH2 N
Molecular Weight16.023
SMILES
PubChem123329
Formal Charge0
Total Atoms3
Total Chiral Atoms0
Total Bonds2
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>9JR3_Chain_A
GIFETKFQV DKVNFHMFD VGRKWIQCF NDVTAIIFV VSSYNRLQE 
ALNFKSIWN NRWLRTISV ILFLNKQDL LAEKVLAGK SKIEDYFPE 
FARYTTPED ATPEPGEDP RVTRAKYFI REFISTASG DGRHCYPHF 
TCAVDTENR RFNDCDIIM LRYLDDDVS AEDKAAAER SKMIDKNLR 
EDGEKARRT LRLLLLGAD NSGKSTIVK QNENVKVDI AIKL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>9JR3_Chain_B
LDQLRQEAE QLKNQIRDA RKACADATL SQITNNIDP VGRIQMRTR 
RTLRGHLAK IYAMHWGTD SRLLVSASQ DGKLIIWDS YTTNKVHAI 
PLRSSWVMT CAYAPSGNY VACGGLDNI CSIYNLKTR EGNVRVSRE 
LAGHTGYLS CCRFLDDNQ IVTSSGDTT CALWDIETG QQTTTFTGH 
TGDVMSLSL APDTRLFVS GACDASAKL WDVREGMCR QTFTGHESD 
INAICFFPN GNAFATGSD DATCRLFDL RADQELMTY SHDNIICGI 
TSVSFSKSG RLLLAGYDD FNCNVWDAL KADRAGVLA GHDNRVSCL 
GVTDDGMAV ATGSWDSFL KIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>9JR3_Chain_G
QARKLVEQL KMEANIDRI KVSKAAADL MAYCEAHAK EDPLLTPVP 
ASENPF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ03431
Sequence
>9JR3_Chain_R
VMTKEEQIF LLHRAQAQC EKRLKECLP EWDHILCWP LGEVVAVPC 
PDYIYDFNH KGHAYRRCW ELVPGHNRT WANYSECVK FLTNETRER 
EVFDRLGMI YTVGYSVSL ASLTVAVLI LAYFRRLHC TRNYIHMHL 
FLSFMLRAV SIFVKDAVL YSYAGCRVA VTFFLYFLA TNYYWILVE 
GLYLHSLIF MAFFSEKKY LWGFTVFGW GLPAVFVAV WVSVRATLA 
NTGCWDLSS GNKKWIIQV PILASIVLN FILFINIVR VLATKLRET 
TRQQYRKLL KSTLVLMPL FGVHYIVFM ATPYTEVSG TLWQVQMHY 
EMLFNSFQG FFVAIIYCF CNGEVQAEI KKSWSRWTL ALDF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9JR3B1PeptideParathyroid HormonePTH1Homo sapiensPTH-chim(NtGi1L-Gs-CtGq)/β1/γ22.82024-10-16To be published
9JR2B1PeptideParathyroid HormonePTH1Homo sapiensPTH-chim(NtGi1L-Gs-CtGq)/β1/γ22.82024-10-16To be published
8JR9B1PeptideParathyroid HormonePTH1Homo sapiens-PCO371chim(NtGi1-Gs)/β1/γ22.572023-08-0210.1038/s41586-023-06467-w
7Y36B1PeptideParathyroid HormonePTH1Homo sapiensTeriparatide-Gs/β1/γ22.82023-07-05To be published
7Y35B1PeptideParathyroid HormonePTH1Homo sapiensAbaloparatide-Gs/β1/γ22.92023-07-05To be published
8GW8B1PeptideParathyroid HormonePTH1Homo sapiens-KHFGs/β1/γ22.92023-06-1410.1038/s41586-023-06169-3
8FLUB1PeptideParathyroid HormonePTH1Homo sapiensLong-Acting PTH-Gs/β1/γ22.762023-04-2610.1016/j.str.2023.04.002
8FLTB1PeptideParathyroid HormonePTH1Homo sapiensM-PTH(1-14)-Gs/β1/γ23.032023-04-2610.1016/j.str.2023.04.002
8FLSB1PeptideParathyroid HormonePTH1Homo sapiensAbaloparatide-Gs/β1/γ23.092023-04-2610.1016/j.str.2023.04.002
8FLRB1PeptideParathyroid HormonePTH1Homo sapiensPTHrP(1-36)-Gs/β1/γ22.942023-04-2610.1016/j.str.2023.04.002
8FLQB1PeptideParathyroid HormonePTH1Homo sapiensPTH-Gs/β1/γ22.552023-04-2610.1016/j.str.2023.04.002
8HAOB1PeptideParathyroid HormonePTH1Homo sapiensPTH-chim(NtGi1-Gs)/β1/γ23.762022-12-2110.1038/s41401-022-01032-z
8HAFB1PeptideParathyroid HormonePTH1Homo sapiensPTHrP(1-36)-chim(NtGi1-Gs)/β1/γ23.252022-12-2110.1038/s41401-022-01032-z
8HA0B1PeptideParathyroid HormonePTH1Homo sapiensPTH-chim(NtGi1-Gs)/β1/γ22.622022-12-2110.1038/s41401-022-01032-z
7VVOB1PeptideParathyroid HormonePTH1Homo sapiensPTH-Gs/β1/γ24.12022-08-0310.1016/j.molcel.2022.07.003
7VVNB1PeptideParathyroid HormonePTH1Homo sapiensPTH-Gs/β1/γ23.82022-08-0310.1016/j.molcel.2022.07.003
7VVMB1PeptideParathyroid HormonePTH1Homo sapiensPTH-Gs/β1/γ23.22022-08-0310.1016/j.molcel.2022.07.003
7VVLB1PeptideParathyroid HormonePTH1Homo sapiensPTH-Gs/β1/γ22.82022-08-0310.1016/j.molcel.2022.07.003
7VVKB1PeptideParathyroid HormonePTH1Homo sapiensPTH-Gs/β1/γ23.32022-08-0310.1016/j.molcel.2022.07.003
7VVJB1PeptideParathyroid HormonePTH1Homo sapiensPTHrP(1-36)-Gs/β1/γ23.22022-08-0310.1016/j.molcel.2022.07.003
6NBIB1PeptideParathyroid HormonePTH1Homo sapiensLong-Acting PTH Analog-Gs/β1/γ242019-04-1710.1126/science.aav7942
6NBHB1PeptideParathyroid HormonePTH1Homo sapiensLong-Acting PTH Analog-Gs/β1/γ23.52019-04-1710.1126/science.aav7942
6NBFB1PeptideParathyroid HormonePTH1Homo sapiensLong-Acting PTH Analog-Gs/β1/γ232019-04-1710.1126/science.aav7942
6FJ3B1PeptideParathyroid HormonePTH1Homo sapiensPTH--2.52018-11-2110.1038/s41594-018-0151-4




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