psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:V2	R:R:Q364	10.03	No	Yes	0	0	7
2	L:L:V2	R:R:I367	7.68	No	No	0	0	7
3	L:L:S3	R:R:Q440	5.78	No	Yes	0	0	6
4	L:L:S3	R:R:E444	11.5	No	No	0	0	7
5	L:L:E4	R:R:Y195	6.73	Yes	Yes	1	0	7
6	L:L:E4	R:R:I237	4.1	Yes	Yes	1	0	7
7	L:L:E4	R:R:L292	3.98	Yes	No	0	0	6
8	L:L:E4	R:R:M445	9.47	Yes	No	0	0	6
9	L:L:E4	R:R:N448	6.57	Yes	Yes	1	0	6
10	L:L:H5	L:L:L8	3.86	Yes	Yes	0	0	0
11	L:L:H5	L:L:H9	20.3	Yes	Yes	0	0	0
12	L:L:H5	R:R:L289	11.57	Yes	Yes	0	0	7
13	L:L:H5	R:R:Q364	6.18	Yes	Yes	0	0	7
14	L:L:D10	L:L:Q6	7.83	No	Yes	1	0	0
15	L:L:Q6	R:R:Y429	27.05	Yes	Yes	1	0	6
16	L:L:Q6	R:R:W437	5.48	Yes	Yes	1	0	5
17	L:L:Q6	R:R:Q440	5.12	Yes	Yes	1	0	6
18	L:L:Q6	R:R:M441	6.8	Yes	No	1	0	6
19	L:L:L7	R:R:M445	4.24	No	No	0	0	6
20	L:L:L8	R:R:K240	5.64	Yes	Yes	1	0	7
21	L:L:L8	R:R:Y245	5.86	Yes	Yes	1	0	4
22	L:L:L8	R:R:F288	3.65	Yes	Yes	1	0	7
23	L:L:L8	R:R:D353	14.93	Yes	Yes	1	0	5
24	L:L:H9	R:R:S355	8.37	Yes	No	0	0	7
25	L:L:H9	R:R:K360	3.93	Yes	Yes	1	0	7
26	L:L:H9	R:R:Y429	5.44	Yes	Yes	1	0	6
27	L:L:D10	R:R:V432	4.38	No	No	1	0	5
28	L:L:D10	R:R:W437	8.93	No	Yes	1	0	5
29	L:L:K11	R:R:F184	12.41	No	Yes	0	0	6
30	L:L:K11	R:R:Y245	21.5	No	Yes	0	0	4
31	L:L:G12	L:L:I15	3.53	No	No	0	0	0
32	L:L:G12	R:R:D353	5.03	No	Yes	0	0	5
33	L:L:D17	L:L:K13	8.3	No	No	6	0	0
34	L:L:K13	R:R:V31	10.62	No	No	6	0	6
35	L:L:I15	L:L:Q16	5.49	No	No	0	0	0
36	L:L:Q16	L:L:R19	14.02	No	Yes	0	0	0
37	L:L:D17	L:L:R20	11.91	No	Yes	0	0	0
38	L:L:D17	R:R:V31	5.84	No	No	6	0	6
39	L:L:F22	L:L:L18	10.96	No	No	0	0	0
40	L:L:L18	R:R:E180	6.63	No	No	0	0	3
41	L:L:R19	R:R:T33	3.88	Yes	No	7	0	7
42	L:L:R19	R:R:K34	7.43	Yes	No	0	0	4
43	L:L:R19	R:R:E35	5.82	Yes	No	7	0	5
44	L:L:R20	R:R:Q37	4.67	Yes	No	0	0	7
45	L:L:R20	R:R:Y136	8.23	Yes	No	0	0	4
46	L:L:R20	R:R:D137	15.48	Yes	No	0	0	5
47	L:L:R21	R:R:D137	15.48	No	No	0	0	5
48	L:L:R21	R:R:E177	18.61	No	No	0	0	1
49	L:L:F23	L:L:L27	3.65	No	No	0	0	0
50	L:L:F23	R:R:I38	3.77	No	No	0	0	7
51	L:L:L24	R:R:F138	6.09	No	Yes	0	0	4
52	L:L:H25	L:L:H26	17.91	No	No	0	0	0
53	L:L:E30	L:L:H26	6.15	No	No	0	0	0
54	L:L:E30	L:L:L27	5.3	No	No	0	0	0
55	L:L:I28	R:R:Y167	31.43	No	Yes	0	0	5
56	L:L:I31	R:R:I115	10.3	No	Yes	0	0	5
57	L:L:I31	R:R:Y167	3.63	No	Yes	0	0	5
58	R:R:L354	R:R:V31	5.96	No	No	0	5	6
59	R:R:E36	R:R:M32	10.83	No	No	0	6	6
60	R:R:M32	R:R:Y136	8.38	No	No	0	6	4
61	R:R:E35	R:R:T33	8.47	No	No	7	5	7
62	R:R:E36	R:R:T33	4.23	No	No	0	6	7
63	R:R:I38	R:R:K34	5.82	No	No	0	7	4
64	R:R:I135	R:R:Q37	6.86	Yes	No	0	7	7
65	R:R:I135	R:R:L41	4.28	Yes	No	0	7	8
66	R:R:A44	R:R:Y134	9.34	No	No	0	7	5
67	R:R:Q45	R:R:W112	21.9	No	Yes	0	7	7
68	R:R:A46	R:R:E49	4.53	No	Yes	0	5	6
69	R:R:C48	R:R:W112	10.45	No	Yes	0	8	7
70	R:R:C117	R:R:C48	7.28	No	No	0	9	8
71	R:R:E49	R:R:K50	4.05	Yes	No	0	6	4
72	R:R:L120	R:R:P107	9.85	No	No	0	4	3
73	R:R:C108	R:R:C148	5.46	No	No	0	9	9
74	R:R:C108	R:R:W154	22.2	No	Yes	0	9	9
75	R:R:L109	R:R:P110	4.93	No	No	0	5	6
76	R:R:D113	R:R:R146	5.96	No	Yes	0	9	8
77	R:R:I115	R:R:L116	7.14	Yes	No	2	5	5
78	R:R:I115	R:R:P132	5.08	Yes	Yes	2	5	9
79	R:R:I115	R:R:I135	4.42	Yes	Yes	2	5	7
80	R:R:F138	R:R:I115	6.28	Yes	Yes	2	4	5
81	R:R:L116	R:R:W118	7.97	No	Yes	2	5	9
82	R:R:L116	R:R:P132	9.85	No	Yes	2	5	9
83	R:R:P119	R:R:W118	4.05	No	Yes	2	6	9
84	R:R:V127	R:R:W118	4.9	Yes	Yes	2	7	9
85	R:R:V129	R:R:W118	8.58	No	Yes	0	5	9
86	R:R:R146	R:R:W118	28.99	Yes	Yes	2	8	9
87	R:R:W118	R:R:W154	10.31	Yes	Yes	2	9	9
88	R:R:P119	R:R:V127	3.53	No	Yes	2	6	7
89	R:R:C148	R:R:G121	3.92	No	No	0	9	7
90	R:R:A122	R:R:E125	4.53	No	No	0	1	5
91	R:R:G124	R:R:R150	7.51	No	No	0	7	1
92	R:R:V126	R:R:Y145	7.57	No	No	0	4	4
93	R:R:V127	R:R:W154	6.13	Yes	Yes	2	7	9
94	R:R:P130	R:R:V129	3.53	No	No	0	5	5
95	R:R:C131	R:R:P132	3.77	Yes	Yes	2	9	9
96	R:R:C131	R:R:F138	6.98	Yes	Yes	2	9	4
97	R:R:C131	R:R:H140	5.9	Yes	No	0	9	3
98	R:R:C131	R:R:C170	5.46	Yes	No	2	9	9
99	R:R:P132	R:R:Y134	15.3	Yes	No	2	9	5
100	R:R:I135	R:R:P132	5.08	Yes	Yes	2	7	9
101	R:R:F138	R:R:P132	5.78	Yes	Yes	2	4	9
102	R:R:D133	R:R:H140	3.78	No	No	0	2	3
103	R:R:I135	R:R:Y134	4.84	Yes	No	2	7	5
104	R:R:F138	R:R:I135	17.58	Yes	Yes	2	4	7
105	R:R:F138	R:R:Y167	10.32	Yes	Yes	2	4	5
106	R:R:C170	R:R:F138	12.57	No	Yes	2	9	4
107	R:R:K141	R:R:N139	5.6	No	No	0	3	4
108	R:R:K172	R:R:N139	18.19	No	No	0	3	4
109	R:R:R147	R:R:Y145	12.35	No	No	0	3	4
110	R:R:N166	R:R:Y145	5.81	No	No	0	7	4
111	R:R:R146	R:R:W154	36.99	Yes	Yes	2	8	9
112	R:R:R146	R:R:T163	9.06	Yes	No	0	8	5
113	R:R:E155	R:R:R147	15.12	No	No	0	4	3
114	R:R:D149	R:R:N151	4.04	No	No	0	5	5
115	R:R:D149	R:R:E155	14.29	No	No	0	5	4
116	R:R:N151	R:R:S153	4.47	No	No	0	5	4
117	R:R:E155	R:R:W164	8.72	No	No	0	4	5
118	R:R:P158	R:R:V157	3.53	No	No	8	4	4
119	R:R:R162	R:R:V157	5.23	No	No	0	3	4
120	R:R:V157	R:R:W164	7.36	No	No	8	4	5
121	R:R:P158	R:R:W164	6.76	No	No	8	4	5
122	R:R:H160	R:R:R162	11.28	No	No	0	4	3
123	R:R:N166	R:R:S168	7.45	No	No	0	7	6
124	R:R:C170	R:R:Y167	6.72	No	Yes	2	9	5
125	R:R:V171	R:R:Y167	15.14	No	Yes	0	3	5
126	R:R:E180	R:R:R181	5.82	No	Yes	0	3	3
127	R:R:F184	R:R:R181	6.41	Yes	Yes	1	6	3
128	R:R:R181	R:R:S433	3.95	Yes	No	0	3	3
129	R:R:R186	R:R:V183	3.92	No	No	0	5	4
130	R:R:Q438	R:R:V183	4.3	No	No	0	4	4
131	R:R:F184	R:R:V432	6.55	Yes	No	1	6	5
132	R:R:F184	R:R:W437	5.01	Yes	Yes	1	6	5
133	R:R:H442	R:R:R186	11.28	No	No	0	5	5
134	R:R:H442	R:R:L187	9	No	No	0	5	5
135	R:R:G188	R:R:Y191	5.79	No	Yes	0	5	7
136	R:R:Y191	R:R:Y195	5.96	Yes	Yes	1	7	7
137	R:R:I237	R:R:Y191	4.84	Yes	Yes	1	7	7
138	R:R:D241	R:R:Y191	6.9	No	Yes	1	8	7
139	R:R:M445	R:R:Y191	8.38	No	Yes	0	6	7
140	R:R:S449	R:R:Y191	3.82	No	Yes	1	9	7
141	R:R:F238	R:R:T192	5.19	No	No	0	7	7
142	R:R:G194	R:R:V193	3.68	No	No	0	9	6
143	R:R:F450	R:R:G194	9.03	Yes	No	0	7	9
144	R:R:R233	R:R:Y195	10.29	Yes	Yes	1	8	7
145	R:R:A234	R:R:Y195	5.34	No	Yes	0	8	7
146	R:R:I237	R:R:Y195	6.04	Yes	Yes	1	7	7
147	R:R:S449	R:R:Y195	6.36	No	Yes	1	9	7
148	R:R:F238	R:R:S196	5.28	No	No	0	7	7
149	R:R:F450	R:R:V197	3.93	Yes	No	0	7	5
150	R:R:G452	R:R:S198	3.71	No	No	0	9	9
151	R:R:L199	R:R:M231	4.24	No	No	0	7	8
152	R:R:F453	R:R:S201	7.93	No	No	0	6	8
153	R:R:F227	R:R:L202	6.09	Yes	Yes	0	9	9
154	R:R:F230	R:R:L202	3.65	Yes	Yes	0	8	9
155	R:R:L202	R:R:M231	4.24	Yes	No	0	9	8
156	R:R:F461	R:R:V204	5.24	No	No	0	8	5
157	R:R:A205	R:R:C460	3.61	No	Yes	0	9	9
158	R:R:F227	R:R:V206	3.93	Yes	No	0	9	5
159	R:R:C460	R:R:I208	4.91	Yes	No	0	9	8
160	R:R:L209	R:R:N220	9.61	Yes	No	0	7	9
161	R:R:L209	R:R:M224	7.07	Yes	No	0	7	5
162	R:R:F227	R:R:L209	3.65	Yes	Yes	0	9	7
163	R:R:F212	R:R:L215	6.09	Yes	No	0	7	9
164	R:R:E469	R:R:F212	25.65	No	Yes	0	9	7
165	R:R:F212	R:R:I470	5.02	Yes	No	0	7	5
166	R:R:E465	R:R:L215	7.95	No	No	0	9	9
167	R:R:L215	R:R:V466	5.96	No	No	0	9	9
168	R:R:C217	R:R:N220	4.72	No	No	0	8	9
169	R:R:T218	R:R:Y305	3.75	No	Yes	3	7	8
170	R:R:E317	R:R:T218	5.64	No	No	3	6	7
171	R:R:L321	R:R:T218	5.9	No	No	0	6	7
172	R:R:N220	R:R:R219	12.05	No	No	0	9	9
173	R:R:E465	R:R:R219	4.65	No	No	0	9	9
174	R:R:H225	R:R:Y221	20.69	Yes	Yes	4	8	7
175	R:R:L321	R:R:Y221	10.55	No	Yes	0	6	7
176	R:R:T325	R:R:Y221	6.24	No	Yes	4	5	7
177	R:R:E302	R:R:I222	5.47	No	No	0	9	9
178	R:R:I222	R:R:Y305	4.84	No	Yes	0	9	8
179	R:R:F227	R:R:H223	4.53	Yes	No	0	9	9
180	R:R:E302	R:R:H223	8.62	No	No	0	9	9
181	R:R:H223	R:R:Y459	5.44	No	No	0	9	8
182	R:R:H225	R:R:W298	15.87	Yes	Yes	4	8	9
183	R:R:H225	R:R:T325	8.21	Yes	No	4	8	5
184	R:R:H225	R:R:W329	5.29	Yes	Yes	4	8	9
185	R:R:F230	R:R:L226	6.09	Yes	No	0	8	9
186	R:R:N295	R:R:S229	7.45	Yes	No	0	8	9
187	R:R:S229	R:R:W298	4.94	No	Yes	0	9	9
188	R:R:F230	R:R:N295	16.92	Yes	Yes	1	8	8
189	R:R:F230	R:R:I299	3.77	Yes	Yes	1	8	9
190	R:R:F230	R:R:Q451	9.37	Yes	Yes	1	8	9
191	R:R:F230	R:R:G452	7.53	Yes	No	0	8	9
192	R:R:F230	R:R:V455	6.55	Yes	No	0	8	9
193	R:R:F291	R:R:L232	13.4	Yes	No	0	5	8
194	R:R:L292	R:R:R233	3.64	No	Yes	0	6	8
195	R:R:N295	R:R:R233	12.05	Yes	Yes	1	8	8
196	R:R:R233	R:R:Y296	12.35	Yes	No	1	8	7
197	R:R:R233	R:R:Y421	4.12	Yes	Yes	1	8	8
198	R:R:N448	R:R:R233	4.82	Yes	Yes	1	6	8
199	R:R:F291	R:R:S236	6.61	Yes	No	0	5	7
200	R:R:F288	R:R:I237	3.77	Yes	Yes	1	7	7
201	R:R:D241	R:R:K240	4.15	No	Yes	1	8	7
202	R:R:K240	R:R:L244	4.23	Yes	Yes	1	7	5
203	R:R:K240	R:R:Y245	7.17	Yes	Yes	1	7	4
204	R:R:F288	R:R:K240	14.89	Yes	Yes	1	7	7
205	R:R:D241	R:R:Y245	6.9	No	Yes	1	8	4
206	R:R:A284	R:R:V243	5.09	No	No	0	6	5
207	R:R:L244	R:R:Y245	4.69	Yes	Yes	1	5	4
208	R:R:L244	R:R:V285	4.47	Yes	No	0	5	6
209	R:R:D353	R:R:L244	8.14	Yes	Yes	1	5	5
210	R:R:D353	R:R:Y245	4.6	Yes	Yes	1	5	4
211	R:R:C281	R:R:C351	7.28	No	No	1	9	9
212	R:R:N348	R:R:R282	13.26	No	No	5	7	8
213	R:R:R282	R:R:W352	24.99	No	Yes	5	8	8
214	R:R:F287	R:R:V283	5.24	No	No	0	3	4
215	R:R:F288	R:R:L289	4.87	Yes	Yes	0	7	7
216	R:R:F288	R:R:L292	3.65	Yes	No	0	7	6
217	R:R:L289	R:R:W339	6.83	Yes	Yes	0	7	8
218	R:R:I363	R:R:L289	5.71	No	Yes	0	7	7
219	R:R:F291	R:R:Y290	7.22	Yes	Yes	0	5	9
220	R:R:T294	R:R:Y290	8.74	No	Yes	0	8	9
221	R:R:A333	R:R:Y290	5.34	No	Yes	0	5	9
222	R:R:V336	R:R:Y290	3.79	No	Yes	0	7	9
223	R:R:T294	R:R:W329	8.49	No	Yes	0	8	9
224	R:R:P332	R:R:T294	5.25	No	No	0	9	8
225	R:R:I299	R:R:N295	5.66	Yes	Yes	1	9	8
226	R:R:I367	R:R:Y296	8.46	No	No	0	7	7
227	R:R:Y296	R:R:Y421	13.9	No	Yes	1	7	8
228	R:R:F327	R:R:Y297	6.19	Yes	Yes	0	5	6
229	R:R:P332	R:R:Y297	9.74	No	Yes	0	9	6
230	R:R:F335	R:R:Y297	4.13	No	Yes	0	5	6
231	R:R:S370	R:R:Y297	6.36	No	Yes	0	7	6
232	R:R:V301	R:R:W298	8.58	No	Yes	0	8	9
233	R:R:G328	R:R:W298	8.44	No	Yes	0	9	9
234	R:R:W298	R:R:W329	24.37	Yes	Yes	4	9	9
235	R:R:I299	R:R:N374	4.25	Yes	No	0	9	9
236	R:R:I299	R:R:Q451	5.49	Yes	Yes	1	9	9
237	R:R:L300	R:R:L304	5.54	Yes	No	0	8	5
238	R:R:F327	R:R:L300	3.65	Yes	Yes	0	5	8
239	R:R:L300	R:R:S370	7.51	Yes	No	0	8	7
240	R:R:L300	R:R:L373	5.54	Yes	No	0	8	7
241	R:R:L300	R:R:N374	9.61	Yes	No	0	8	9
242	R:R:F324	R:R:V301	6.55	No	No	0	7	8
243	R:R:F327	R:R:V301	3.93	Yes	No	0	5	8
244	R:R:E302	R:R:L416	11.93	No	No	0	9	9
245	R:R:F417	R:R:G303	6.02	No	No	0	9	9
246	R:R:L304	R:R:L377	4.15	No	No	0	5	7
247	R:R:L309	R:R:Y305	14.07	No	Yes	3	8	8
248	R:R:F315	R:R:Y305	4.13	Yes	Yes	3	6	8
249	R:R:E317	R:R:Y305	5.61	No	Yes	3	6	8
250	R:R:F324	R:R:Y305	7.22	No	Yes	0	7	8
251	R:R:F311	R:R:H307	18.1	No	Yes	9	6	8
252	R:R:H307	R:R:L377	10.29	Yes	No	0	8	7
253	R:R:H307	R:R:N380	8.93	Yes	No	9	8	8
254	R:R:H307	R:R:I381	3.98	Yes	No	0	8	9
255	R:R:F315	R:R:S308	13.21	Yes	No	0	6	7
256	R:R:F315	R:R:L309	4.87	Yes	No	3	6	8
257	R:R:F311	R:R:N380	12.08	No	No	9	6	8
258	R:R:F311	R:R:V384	6.55	No	No	0	6	8
259	R:R:F315	R:R:M312	6.22	Yes	No	0	6	5
260	R:R:F315	R:R:Y320	12.38	Yes	No	0	6	4
261	R:R:K319	R:R:S316	13.77	No	No	0	6	7
262	R:R:F327	R:R:L331	4.87	Yes	No	0	5	4
263	R:R:F335	R:R:P366	17.34	No	No	0	5	9
264	R:R:I363	R:R:V336	6.14	No	No	0	7	7
265	R:R:V340	R:R:W339	4.9	No	Yes	0	5	8
266	R:R:R343	R:R:W339	7	No	Yes	5	8	8
267	R:R:W339	R:R:W352	3.75	Yes	Yes	5	8	8
268	R:R:R343	R:R:W352	14.99	No	Yes	5	8	8
269	R:R:R343	R:R:S356	6.59	No	Yes	0	8	4
270	R:R:L346	R:R:T345	4.42	No	No	0	3	3
271	R:R:N348	R:R:W352	6.78	No	Yes	5	7	8
272	R:R:G357	R:R:S356	3.71	No	Yes	0	6	4
273	R:R:K359	R:R:S356	10.71	No	Yes	0	3	4
274	R:R:N358	R:R:W361	5.65	No	Yes	0	4	8
275	R:R:K360	R:R:W361	9.28	Yes	Yes	1	7	8
276	R:R:K360	R:R:Q364	8.14	Yes	Yes	1	7	7
277	R:R:K360	R:R:Y429	13.14	Yes	Yes	1	7	6
278	R:R:Q364	R:R:W361	12.05	Yes	Yes	1	7	8
279	R:R:V365	R:R:W361	3.68	No	Yes	0	5	8
280	R:R:Q364	R:R:Y429	5.64	Yes	Yes	1	7	6
281	R:R:P366	R:R:V365	5.3	No	No	0	9	5
282	R:R:L368	R:R:M425	4.24	No	Yes	0	4	6
283	R:R:I371	R:R:Y421	9.67	No	Yes	0	7	8
284	R:R:I371	R:R:M425	5.83	No	Yes	0	7	6
285	R:R:L373	R:R:L377	4.15	No	No	0	7	7
286	R:R:F375	R:R:I379	3.77	No	No	0	7	5
287	R:R:F375	R:R:I422	13.82	No	No	0	7	5
288	R:R:F378	R:R:V382	6.55	No	No	0	9	7
289	R:R:F378	R:R:F417	5.36	No	No	0	9	9
290	R:R:F378	R:R:V419	5.24	No	No	0	9	7
291	R:R:T410	R:R:V382	4.76	No	No	0	9	7
292	R:R:L385	R:R:S409	6.01	No	No	0	8	9
293	R:R:R390	R:R:T387	3.88	No	No	0	6	7
294	R:R:E391	R:R:T387	4.23	No	No	0	7	7
295	R:R:L389	R:R:Q402	5.32	No	No	0	8	6
296	R:R:K405	R:R:L389	4.23	No	No	0	8	8
297	R:R:C397	R:R:T392	6.76	No	No	0	5	7
298	R:R:C397	R:R:N393	7.87	No	No	0	5	7
299	R:R:D398	R:R:R400	20.25	No	No	0	6	8
300	R:R:D398	R:R:Q402	6.53	No	No	0	6	6
301	R:R:Q401	R:R:T399	12.76	No	No	0	6	6
302	R:R:Q402	R:R:T399	4.25	No	No	0	6	6
303	R:R:K405	R:R:R404	4.95	No	No	0	8	6
304	R:R:K405	R:R:K408	7.18	No	No	0	8	8
305	R:R:I458	R:R:V412	6.14	No	No	0	8	8
306	R:R:M414	R:R:V419	7.61	No	No	0	8	7
307	R:R:F417	R:R:L416	7.31	No	No	0	9	9
308	R:R:L416	R:R:Y459	19.93	No	No	0	9	8
309	R:R:H420	R:R:Y421	18.51	Yes	Yes	1	8	8
310	R:R:H420	R:R:Y443	4.36	Yes	Yes	1	8	4
311	R:R:F447	R:R:H420	5.66	No	Yes	1	5	8
312	R:R:H420	R:R:N448	5.1	Yes	Yes	1	8	6
313	R:R:H420	R:R:Q451	8.65	Yes	Yes	1	8	9
314	R:R:N448	R:R:Y421	13.96	Yes	Yes	1	6	8
315	R:R:Q451	R:R:Y421	10.15	Yes	Yes	1	9	8
316	R:R:F424	R:R:V423	6.55	Yes	No	1	7	6
317	R:R:V423	R:R:Y443	5.05	No	Yes	1	6	4
318	R:R:F424	R:R:T427	3.89	Yes	No	1	7	5
319	R:R:F424	R:R:Q440	5.86	Yes	Yes	1	7	6
320	R:R:F424	R:R:Y443	8.25	Yes	Yes	1	7	4
321	R:R:E444	R:R:F424	7	No	Yes	0	7	7
322	R:R:Q440	R:R:T427	9.92	Yes	No	1	6	5
323	R:R:T430	R:R:W437	6.06	No	Yes	0	5	5
324	R:R:E431	R:R:S433	4.31	No	No	0	3	3
325	R:R:V432	R:R:W437	13.48	No	Yes	1	5	5
326	R:R:Q438	R:R:W437	7.67	No	Yes	0	4	5
327	R:R:M441	R:R:W437	19.78	No	Yes	1	6	5
328	R:R:M441	R:R:Q440	5.44	No	Yes	1	6	6
329	R:R:F447	R:R:Y443	10.32	No	Yes	1	5	4
330	R:R:E444	R:R:N448	6.57	No	Yes	0	7	6
331	R:R:F453	R:R:I457	11.3	No	No	0	6	6
332	R:R:I458	R:R:Y459	12.09	No	No	0	8	8
333	R:R:C460	R:R:F461	4.19	Yes	No	0	9	8
334	R:R:E465	R:R:N463	5.26	No	No	0	9	9
335	R:R:N463	R:R:V466	8.87	No	No	0	9	9
336	R:R:E469	R:R:K472	4.05	No	No	0	9	7
337	R:R:E469	R:R:S473	5.75	No	No	0	9	4
338	R:R:T478	R:R:W474	14.55	No	No	0	4	5
339	R:R:I362	R:R:W339	3.52	No	Yes	0	8	8
340	R:R:P428	R:R:T427	3.5	No	No	0	7	5
341	R:R:A456	R:R:S201	3.42	No	No	0	8	8
342	R:R:L228	R:R:W329	3.42	No	Yes	0	4	9
343	R:R:G142	R:R:N139	3.39	No	No	0	5	4
344	R:R:E169	R:R:G142	3.27	No	No	0	5	5
345	R:R:A293	R:R:I367	3.25	No	No	0	6	7
346	R:R:F450	R:R:F453	3.22	Yes	No	0	7	6
347	R:R:F450	R:R:F454	3.22	Yes	No	0	7	6
348	R:R:H114	R:R:W112	3.17	No	Yes	0	4	7
349	R:R:C460	R:R:L209	3.17	Yes	Yes	0	9	7
350	R:R:C281	R:R:L244	3.17	No	Yes	1	9	5
351	R:R:C351	R:R:L244	3.17	No	Yes	1	9	5
352	R:R:T286	R:R:V340	3.17	No	No	0	7	5
353	R:R:A456	R:R:L202	3.15	No	Yes	0	8	9
354	R:R:A386	R:R:L406	3.15	No	No	0	6	8
355	R:R:F212	R:R:Y211	3.09	Yes	No	0	7	2
356	R:R:I362	R:R:V338	3.07	No	No	0	8	5
357	R:R:K359	R:R:V342	3.04	No	No	0	3	5
358	R:R:M425	R:R:V372	3.04	Yes	No	0	6	4
359	L:L:A1	L:L:Q6	3.03	No	Yes	0	0	0
360	R:R:M231	R:R:T203	3.01	No	No	0	8	3
361	R:R:G395	R:R:R400	3	No	No	0	5	8
362	R:R:L199	R:R:V235	2.98	No	No	0	7	4
363	R:R:L436	R:R:T430	2.95	No	No	0	4	5
364	R:R:A128	R:R:H143	2.93	No	No	0	5	3
365	R:R:G350	R:R:Y278	2.9	No	No	0	5	4
366	R:R:G418	R:R:Y421	2.9	No	Yes	0	9	8
367	R:R:F454	R:R:P415	2.89	No	No	0	6	9
368	R:R:I190	R:R:L446	2.85	No	No	0	6	5
369	R:R:I310	R:R:L306	2.85	No	No	0	8	9
370	R:R:I381	R:R:L306	2.85	No	No	0	9	9
371	R:R:I310	R:R:L309	2.85	No	No	0	8	8
372	R:R:I381	R:R:L413	2.85	No	No	0	9	9
373	R:R:A165	R:R:R146	2.77	No	Yes	0	7	8
374	R:R:A313	R:R:F314	2.77	No	No	0	7	7
375	R:R:L389	R:R:L406	2.77	No	No	0	8	8
376	R:R:E36	R:R:L40	2.65	No	No	0	6	5
377	R:R:E49	R:R:L52	2.65	Yes	No	0	6	4
378	L:L:S14	R:R:R181	2.64	No	Yes	1	0	3
379	L:L:S14	R:R:F184	2.64	No	Yes	1	0	6
380	R:R:F375	R:R:V419	2.62	No	No	0	7	7
381	R:R:A44	R:R:W112	2.59	No	Yes	0	7	7
382	R:R:A144	R:R:W118	2.59	No	Yes	0	7	9
383	R:R:R179	R:R:T178	2.59	No	No	0	3	3
384	R:R:E49	R:R:Q45	2.55	Yes	No	0	6	7
385	R:R:S316	R:R:Y320	2.54	No	No	0	7	4
386	R:R:F238	R:R:L199	2.44	No	No	0	7	7
387	R:R:F450	R:R:L446	2.44	Yes	No	0	7	5
388	R:R:L40	R:R:R43	2.43	No	No	0	5	4
389	R:R:E182	R:R:R179	2.33	No	No	0	2	3
390	R:R:F287	R:R:F291	2.14	No	Yes	0	3	5
391	R:R:R282	R:R:Y278	2.06	No	No	0	8	4
392	R:R:G330	R:R:P332	2.03	No	No	0	7	9
393	R:R:C148	R:R:G152	1.96	No	No	0	9	9
394	R:R:P107	R:R:P123	1.95	No	No	0	3	7
395	R:R:A279	R:R:G280	1.95	No	No	0	4	4
396	R:R:A122	R:R:P123	1.87	No	No	0	1	7
397	R:R:G247	R:R:S246	1.86	No	No	0	4	4
398	R:R:G434	R:R:S433	1.86	No	No	0	5	3
399	R:R:G323	R:R:V326	1.84	No	No	0	1	4
400	R:R:A242	R:R:S246	1.71	No	No	0	4	4
401	R:R:C281	R:R:V243	1.71	No	No	0	9	5
402	R:R:A347	R:R:S356	1.71	No	Yes	0	7	4
403	R:R:A284	R:R:V239	1.7	No	No	0	6	5
404	R:R:G464	R:R:N463	1.7	No	No	0	7	9
405	R:R:L120	R:R:P110	1.64	No	No	0	4	6
406	R:R:C462	R:R:I457	1.64	No	No	0	6	6
407	R:R:C462	R:R:I458	1.64	No	No	0	6	8
408	R:R:G464	R:R:Q467	1.64	No	No	0	7	8
409	L:L:A29	L:L:I28	1.62	No	No	0	0	0
410	R:R:A210	R:R:M224	1.61	No	No	0	4	5
411	R:R:A426	R:R:M425	1.61	No	Yes	0	5	6
412	R:R:S409	R:R:T410	1.6	No	No	0	9	9
413	R:R:G142	R:R:H143	1.59	No	No	0	5	3
414	R:R:I376	R:R:V372	1.54	No	No	0	4	4
415	R:R:K318	R:R:S316	1.53	No	No	0	5	7
416	R:R:M189	R:R:V193	1.52	No	No	0	4	6
417	R:R:L406	R:R:S409	1.5	No	No	0	8	9
418	R:R:L331	R:R:V334	1.49	No	No	0	4	4
419	R:R:L346	R:R:V342	1.49	No	No	0	3	5
420	R:R:L156	R:R:T163	1.47	No	No	0	4	5
421	R:R:D398	R:R:T392	1.45	No	No	0	6	7
422	R:R:P107	R:R:R106	1.44	No	No	0	3	1
423	R:R:E169	R:R:S168	1.44	No	No	0	5	6
424	R:R:K471	R:R:K472	1.44	No	No	0	5	7
425	R:R:E125	R:R:V126	1.43	No	No	0	5	4
426	R:R:E125	R:R:V127	1.43	No	Yes	0	5	7
427	R:R:E177	R:R:T178	1.41	No	No	0	1	3
428	R:R:L411	R:R:M414	1.41	No	No	0	8	8
429	R:R:L407	R:R:L411	1.38	No	No	0	8	8
430	R:R:H216	R:R:M224	1.31	No	No	0	8	5
431	R:R:R383	R:R:V382	1.31	No	No	0	8	7
432	R:R:F424	R:R:V439	1.31	Yes	No	0	7	5
433	R:R:A344	R:R:W352	1.3	No	Yes	0	4	8
434	R:R:K472	R:R:R214	1.24	No	No	0	7	7
435	R:R:V326	R:R:W322	1.23	No	No	0	4	3
436	L:L:R21	R:R:N176	1.21	No	No	0	0	3
437	R:R:N161	R:R:R162	1.21	No	No	0	7	3
438	R:R:E111	R:R:R146	1.16	No	Yes	0	7	8
439	R:R:R213	R:R:R214	1.07	No	No	0	8	7
440	R:R:W322	R:R:Y221	0.96	No	Yes	0	3	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:E4	6.17	5	1	0
2	L:L:H5	10.4775	4	0	0
3	L:L:Q6	9.21833	6	1	0
4	L:L:L8	6.788	5	1	0
5	L:L:H9	9.51	4	1	0
6	L:L:R19	7.7875	4	7	0
7	L:L:R20	10.0725	4	0	0
8	R:R:E49	3.445	4	0	6
9	R:R:W112	9.5275	4	0	7
10	R:R:I115	6.644	5	2	5
11	R:R:W118	9.62714	7	2	9
12	R:R:V127	3.9975	4	2	7
13	R:R:C131	5.5275	4	2	9
14	R:R:P132	7.47667	6	2	9
15	R:R:I135	7.17667	6	2	7
16	R:R:F138	9.37143	7	2	4
17	R:R:R146	14.155	6	2	8
18	R:R:W154	18.9075	4	2	9
19	R:R:Y167	13.448	5	2	5
20	R:R:R181	4.705	4	1	3
21	R:R:F184	6.604	5	1	6
22	R:R:Y191	5.94833	6	1	7
23	R:R:Y195	6.78667	6	1	7
24	R:R:L202	4.2825	4	0	9
25	R:R:L209	5.875	4	0	7
26	R:R:F212	9.9625	4	0	7
27	R:R:Y221	9.61	4	4	7
28	R:R:H225	12.515	4	4	8
29	R:R:F227	4.55	4	0	9
30	R:R:F230	7.69714	7	1	8
31	R:R:R233	7.87833	6	1	8
32	R:R:I237	4.6875	4	1	7
33	R:R:K240	7.216	5	1	7
34	R:R:L244	4.645	6	1	5
35	R:R:Y245	8.45333	6	1	4
36	R:R:F288	6.166	5	1	7
37	R:R:L289	7.245	4	0	7
38	R:R:Y290	6.2725	4	0	9
39	R:R:F291	7.3425	4	0	5
40	R:R:N295	10.52	4	1	8
41	R:R:Y297	6.605	4	0	6
42	R:R:W298	12.44	5	4	9
43	R:R:I299	4.7925	4	1	9
44	R:R:L300	6.37	5	0	8
45	R:R:Y305	6.60333	6	3	8
46	R:R:H307	10.325	4	9	8
47	R:R:F315	8.162	5	3	6
48	R:R:F327	4.66	4	0	5
49	R:R:W329	10.3925	4	4	9
50	R:R:W339	5.2	5	5	8
51	R:R:W352	10.362	5	5	8
52	R:R:D353	8.175	4	1	5
53	R:R:S356	5.68	4	0	4
54	R:R:K360	8.6225	4	1	7
55	R:R:W361	7.665	4	1	8
56	R:R:Q364	8.408	5	1	7
57	R:R:H420	8.456	5	1	8
58	R:R:Y421	10.4586	7	1	8
59	R:R:F424	5.47667	6	1	7
60	R:R:M425	3.68	4	0	6
61	R:R:Y429	12.8175	4	1	6
62	R:R:W437	9.48714	7	1	5
63	R:R:Q440	6.424	5	1	6
64	R:R:Y443	6.995	4	1	4
65	R:R:N448	7.404	5	1	6
66	R:R:F450	4.368	5	0	7
67	R:R:Q451	8.415	4	1	9
68	R:R:C460	3.97	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:Q6	R:R:Q440	14.5172	5.12	Yes	Yes	1	0	6
2	R:R:E444	R:R:N448	10.8118	6.57	No	Yes	0	7	6
3	R:R:L292	R:R:R233	71.9832	3.64	No	Yes	0	6	8
4	L:L:H5	L:L:L8	21.1418	3.86	Yes	Yes	0	0	0
5	L:L:L8	R:R:F288	73.363	3.65	Yes	Yes	1	0	7
6	L:L:H5	R:R:L289	13.3161	11.57	Yes	Yes	0	0	7
7	R:R:F288	R:R:L289	20.038	4.87	Yes	Yes	0	7	7
8	L:L:Q6	R:R:W437	10.9761	5.48	Yes	Yes	1	0	5
9	L:L:L8	R:R:D353	86.5675	14.93	Yes	Yes	1	0	5
10	L:L:K11	R:R:Y245	21.732	21.5	No	Yes	0	0	4
11	R:R:F184	R:R:W437	13.1837	5.01	Yes	Yes	1	6	5
12	L:L:G12	R:R:D353	100	5.03	No	Yes	0	0	5
13	L:L:G12	L:L:I15	99.606	3.53	No	No	0	0	0
14	L:L:R20	R:R:Y136	92.4184	8.23	Yes	No	0	0	4
15	R:R:M32	R:R:Y136	92.8682	8.38	No	No	0	6	4
16	R:R:E36	R:R:M32	93.3132	10.83	No	No	0	6	6
17	R:R:E36	R:R:T33	94.6292	4.23	No	No	0	6	7
18	L:L:R19	R:R:T33	94.8318	3.88	Yes	No	7	0	7
19	L:L:Q16	L:L:R19	98.8084	14.02	No	Yes	0	0	0
20	L:L:I15	L:L:Q16	99.2088	5.49	No	No	0	0	0
21	R:R:F184	R:R:R181	14.2237	6.41	Yes	Yes	1	6	3
22	L:L:R20	R:R:Q37	86.7924	4.67	Yes	No	0	0	7
23	R:R:I135	R:R:Q37	86.3027	6.86	Yes	No	0	7	7
24	R:R:I115	R:R:I135	34.7083	4.42	Yes	Yes	2	5	7
25	R:R:I115	R:R:L116	34.2761	7.14	Yes	No	2	5	5
26	R:R:L116	R:R:W118	67.9476	7.97	No	Yes	2	5	9
27	R:R:V127	R:R:W118	45.343	4.9	Yes	Yes	2	7	9
28	R:R:E125	R:R:V127	44.5024	1.43	No	Yes	0	5	7
29	R:R:A122	R:R:E125	10.6395	4.53	No	No	0	1	5
30	R:R:I135	R:R:P132	36.0674	5.08	Yes	Yes	2	7	9
31	R:R:L116	R:R:P132	35.0337	9.85	No	Yes	2	5	9
32	R:R:E125	R:R:V126	32.9154	1.43	No	No	0	5	4
33	R:R:V126	R:R:Y145	31.4527	7.57	No	No	0	4	4
34	R:R:N166	R:R:Y145	13.6511	5.81	No	No	0	7	4
35	R:R:N166	R:R:S168	12.1469	7.45	No	No	0	7	6
36	R:R:E169	R:R:S168	10.6395	1.44	No	No	0	5	6
37	R:R:R147	R:R:Y145	16.6499	12.35	No	No	0	3	4
38	R:R:E155	R:R:R147	15.1521	15.12	No	No	0	4	3
39	R:R:N295	R:R:R233	78.0989	12.05	Yes	Yes	1	8	8
40	R:R:F230	R:R:N295	54.9712	16.92	Yes	Yes	1	8	8
41	R:R:F230	R:R:L202	71.8859	3.65	Yes	Yes	0	8	9
42	R:R:F230	R:R:Q451	16.5399	9.37	Yes	Yes	1	8	9
43	R:R:A456	R:R:L202	10.4098	3.15	No	Yes	0	8	9
44	R:R:F227	R:R:L202	60.2303	6.09	Yes	Yes	0	9	9
45	R:R:F227	R:R:L209	23.1341	3.65	Yes	Yes	0	9	7
46	R:R:L209	R:R:N220	15.9704	9.61	Yes	No	0	7	9
47	R:R:N220	R:R:R219	14.3434	12.05	No	No	0	9	9
48	R:R:E465	R:R:R219	13.5251	4.65	No	No	0	9	9
49	R:R:N295	R:R:S229	19.0027	7.45	Yes	No	0	8	9
50	R:R:S229	R:R:W298	18.3854	4.94	No	Yes	0	9	9
51	R:R:V301	R:R:W298	11.8853	8.58	No	Yes	0	8	9
52	R:R:F324	R:R:V301	12.2011	6.55	No	No	0	7	8
53	R:R:F324	R:R:Y305	11.6763	7.22	No	Yes	0	7	8
54	R:R:F227	R:R:H223	44.3429	4.53	Yes	No	0	9	9
55	R:R:E302	R:R:H223	22.7784	8.62	No	No	0	9	9
56	R:R:H223	R:R:Y459	22.3956	5.44	No	No	0	9	8
57	R:R:I299	R:R:N295	10.2216	5.66	Yes	Yes	1	9	8
58	R:R:I363	R:R:L289	11.8566	5.71	No	Yes	0	7	7
59	R:R:I363	R:R:V336	11.0319	6.14	No	No	0	7	7
60	R:R:V336	R:R:Y290	10.4305	3.79	No	Yes	0	7	9
61	R:R:L289	R:R:W339	21.0014	6.83	Yes	Yes	0	7	8
62	R:R:I299	R:R:N374	15.5971	4.25	Yes	No	0	9	9
63	R:R:L300	R:R:N374	14.9798	9.61	Yes	No	0	8	9
64	R:R:E302	R:R:L416	22.9969	11.93	No	No	0	9	9
65	R:R:L416	R:R:Y459	20.5149	19.93	No	No	0	9	8
66	R:R:F417	R:R:L416	40.9134	7.31	No	No	0	9	9
67	R:R:F378	R:R:F417	38.275	5.36	No	No	0	9	9
68	R:R:F378	R:R:V382	27.5941	6.55	No	No	0	9	7
69	R:R:T410	R:R:V382	24.8919	4.76	No	No	0	9	7
70	R:R:S409	R:R:T410	23.5361	1.6	No	No	0	9	9
71	R:R:L406	R:R:S409	20.8148	1.5	No	No	0	8	9
72	R:R:L389	R:R:L406	18.0807	2.77	No	No	0	8	8
73	R:R:L389	R:R:Q402	12.5744	5.32	No	No	0	8	6
74	R:R:H420	R:R:Y443	15.5652	4.36	Yes	Yes	1	8	4
75	R:R:F424	R:R:Q440	16.5845	5.86	Yes	Yes	1	7	6
76	R:R:F288	R:R:L292	74.8768	3.65	Yes	No	0	7	6
77	R:R:F424	R:R:Y443	12.048	8.25	Yes	Yes	1	7	4
78	L:L:K11	R:R:F184	20.3458	12.41	No	Yes	0	0	6
79	R:R:D353	R:R:Y245	12.0193	4.6	Yes	Yes	1	5	4
80	R:R:H420	R:R:Q451	14.2987	8.65	Yes	Yes	1	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:V2	R:R:Q364	10.03	0	No	Yes	0	7	0	1
L:L:V2	R:R:I367	7.68	0	No	No	0	7	0	1
L:L:S3	R:R:Q440	5.78	0	No	Yes	0	6	0	1
L:L:S3	R:R:E444	11.5	0	No	No	0	7	0	1
L:L:E4	R:R:Y195	6.73	1	Yes	Yes	0	7	0	1
L:L:E4	R:R:I237	4.1	1	Yes	Yes	0	7	0	1
L:L:E4	R:R:L292	3.98	1	Yes	No	0	6	0	1
L:L:E4	R:R:M445	9.47	1	Yes	No	0	6	0	1
L:L:E4	R:R:N448	6.57	1	Yes	Yes	0	6	0	1
L:L:H5	R:R:L289	11.57	0	Yes	Yes	0	7	0	1
L:L:H5	R:R:Q364	6.18	0	Yes	Yes	0	7	0	1
L:L:Q6	R:R:Y429	27.05	1	Yes	Yes	0	6	0	1
L:L:Q6	R:R:W437	5.48	1	Yes	Yes	0	5	0	1
L:L:Q6	R:R:Q440	5.12	1	Yes	Yes	0	6	0	1
L:L:Q6	R:R:M441	6.8	1	Yes	No	0	6	0	1
L:L:L7	R:R:M445	4.24	0	No	No	0	6	0	1
L:L:L8	R:R:K240	5.64	1	Yes	Yes	0	7	0	1
L:L:L8	R:R:Y245	5.86	1	Yes	Yes	0	4	0	1
L:L:L8	R:R:F288	3.65	1	Yes	Yes	0	7	0	1
L:L:L8	R:R:D353	14.93	1	Yes	Yes	0	5	0	1
L:L:H9	R:R:S355	8.37	1	Yes	No	0	7	0	1
L:L:H9	R:R:K360	3.93	1	Yes	Yes	0	7	0	1
L:L:H9	R:R:Y429	5.44	1	Yes	Yes	0	6	0	1
L:L:D10	R:R:V432	4.38	1	No	No	0	5	0	1
L:L:D10	R:R:W437	8.93	1	No	Yes	0	5	0	1
L:L:K11	R:R:F184	12.41	0	No	Yes	0	6	0	1
L:L:K11	R:R:Y245	21.5	0	No	Yes	0	4	0	1
L:L:G12	R:R:D353	5.03	0	No	Yes	0	5	0	1
L:L:K13	R:R:V31	10.62	6	No	No	0	6	0	1
L:L:D17	R:R:V31	5.84	6	No	No	0	6	0	1
L:L:L18	R:R:E180	6.63	0	No	No	0	3	0	1
L:L:R19	R:R:T33	3.88	7	Yes	No	0	7	0	1
L:L:R19	R:R:K34	7.43	7	Yes	No	0	4	0	1
L:L:R19	R:R:E35	5.82	7	Yes	No	0	5	0	1
L:L:R20	R:R:Q37	4.67	0	Yes	No	0	7	0	1
L:L:R20	R:R:Y136	8.23	0	Yes	No	0	4	0	1
L:L:R20	R:R:D137	15.48	0	Yes	No	0	5	0	1
L:L:R21	R:R:D137	15.48	0	No	No	0	5	0	1
L:L:R21	R:R:E177	18.61	0	No	No	0	1	0	1
L:L:F23	R:R:I38	3.77	0	No	No	0	7	0	1
L:L:L24	R:R:F138	6.09	0	No	Yes	0	4	0	1
L:L:I28	R:R:Y167	31.43	0	No	Yes	0	5	0	1
L:L:I31	R:R:I115	10.3	0	No	Yes	0	5	0	1
L:L:I31	R:R:Y167	3.63	0	No	Yes	0	5	0	1
R:R:L354	R:R:V31	5.96	0	No	No	5	6	2	1
R:R:E36	R:R:M32	10.83	0	No	No	6	6	2	2
R:R:M32	R:R:Y136	8.38	0	No	No	6	4	2	1
R:R:E35	R:R:T33	8.47	7	No	No	5	7	1	1
R:R:E36	R:R:T33	4.23	0	No	No	6	7	2	1
R:R:I38	R:R:K34	5.82	0	No	No	7	4	1	1
R:R:I135	R:R:Q37	6.86	2	Yes	No	7	7	2	1
R:R:I115	R:R:L116	7.14	2	Yes	No	5	5	1	2
R:R:I115	R:R:P132	5.08	2	Yes	Yes	5	9	1	2
R:R:I115	R:R:I135	4.42	2	Yes	Yes	5	7	1	2
R:R:F138	R:R:I115	6.28	2	Yes	Yes	4	5	1	1
R:R:L116	R:R:P132	9.85	2	No	Yes	5	9	2	2
R:R:C131	R:R:P132	3.77	2	Yes	Yes	9	9	2	2
R:R:C131	R:R:F138	6.98	2	Yes	Yes	9	4	2	1
R:R:C131	R:R:C170	5.46	2	Yes	No	9	9	2	2
R:R:I135	R:R:P132	5.08	2	Yes	Yes	7	9	2	2
R:R:F138	R:R:P132	5.78	2	Yes	Yes	4	9	1	2
R:R:F138	R:R:I135	17.58	2	Yes	Yes	4	7	1	2
R:R:F138	R:R:Y167	10.32	2	Yes	Yes	4	5	1	1
R:R:C170	R:R:F138	12.57	2	No	Yes	9	4	2	1
R:R:C170	R:R:Y167	6.72	2	No	Yes	9	5	2	1
R:R:V171	R:R:Y167	15.14	0	No	Yes	3	5	2	1
R:R:E180	R:R:R181	5.82	0	No	Yes	3	3	1	1
R:R:F184	R:R:R181	6.41	1	Yes	Yes	6	3	1	1
R:R:R181	R:R:S433	3.95	1	Yes	No	3	3	1	2
R:R:F184	R:R:V432	6.55	1	Yes	No	6	5	1	1
R:R:F184	R:R:W437	5.01	1	Yes	Yes	6	5	1	1
R:R:Y191	R:R:Y195	5.96	1	Yes	Yes	7	7	2	1
R:R:I237	R:R:Y191	4.84	1	Yes	Yes	7	7	1	2
R:R:D241	R:R:Y191	6.9	1	No	Yes	8	7	2	2
R:R:M445	R:R:Y191	8.38	0	No	Yes	6	7	1	2
R:R:S449	R:R:Y191	3.82	1	No	Yes	9	7	2	2
R:R:R233	R:R:Y195	10.29	1	Yes	Yes	8	7	2	1
R:R:A234	R:R:Y195	5.34	0	No	Yes	8	7	2	1
R:R:I237	R:R:Y195	6.04	1	Yes	Yes	7	7	1	1
R:R:S449	R:R:Y195	6.36	1	No	Yes	9	7	2	1
R:R:L292	R:R:R233	3.64	0	No	Yes	6	8	1	2
R:R:R233	R:R:Y296	12.35	1	Yes	No	8	7	2	2
R:R:R233	R:R:Y421	4.12	1	Yes	Yes	8	8	2	2
R:R:N448	R:R:R233	4.82	1	Yes	Yes	6	8	1	2
R:R:F288	R:R:I237	3.77	1	Yes	Yes	7	7	1	1
R:R:D241	R:R:K240	4.15	1	No	Yes	8	7	2	1
R:R:K240	R:R:L244	4.23	1	Yes	Yes	7	5	1	2
R:R:K240	R:R:Y245	7.17	1	Yes	Yes	7	4	1	1
R:R:F288	R:R:K240	14.89	1	Yes	Yes	7	7	1	1
R:R:D241	R:R:Y245	6.9	1	No	Yes	8	4	2	1
R:R:L244	R:R:Y245	4.69	1	Yes	Yes	5	4	2	1
R:R:D353	R:R:L244	8.14	1	Yes	Yes	5	5	1	2
R:R:D353	R:R:Y245	4.6	1	Yes	Yes	5	4	1	1
R:R:F288	R:R:L289	4.87	1	Yes	Yes	7	7	1	1
R:R:F288	R:R:L292	3.65	1	Yes	No	7	6	1	1
R:R:L289	R:R:W339	6.83	0	Yes	Yes	7	8	1	2
R:R:I363	R:R:L289	5.71	0	No	Yes	7	7	2	1
R:R:I367	R:R:Y296	8.46	0	No	No	7	7	1	2
R:R:Y296	R:R:Y421	13.9	1	No	Yes	7	8	2	2
R:R:K360	R:R:W361	9.28	1	Yes	Yes	7	8	1	2
R:R:K360	R:R:Q364	8.14	1	Yes	Yes	7	7	1	1
R:R:K360	R:R:Y429	13.14	1	Yes	Yes	7	6	1	1
R:R:Q364	R:R:W361	12.05	1	Yes	Yes	7	8	1	2
R:R:Q364	R:R:Y429	5.64	1	Yes	Yes	7	6	1	1
R:R:H420	R:R:Y421	18.51	1	Yes	Yes	8	8	2	2
R:R:H420	R:R:N448	5.1	1	Yes	Yes	8	6	2	1
R:R:N448	R:R:Y421	13.96	1	Yes	Yes	6	8	1	2
R:R:F424	R:R:T427	3.89	1	Yes	No	7	5	2	2
R:R:F424	R:R:Q440	5.86	1	Yes	Yes	7	6	2	1
R:R:E444	R:R:F424	7	0	No	Yes	7	7	1	2
R:R:Q440	R:R:T427	9.92	1	Yes	No	6	5	1	2
R:R:T430	R:R:W437	6.06	0	No	Yes	5	5	2	1
R:R:V432	R:R:W437	13.48	1	No	Yes	5	5	1	1
R:R:Q438	R:R:W437	7.67	0	No	Yes	4	5	2	1
R:R:M441	R:R:W437	19.78	1	No	Yes	6	5	1	1
R:R:M441	R:R:Q440	5.44	1	No	Yes	6	6	1	1
R:R:E444	R:R:N448	6.57	0	No	Yes	7	6	1	1
R:R:A293	R:R:I367	3.25	0	No	No	6	7	2	1
L:L:S14	R:R:R181	2.64	1	No	Yes	0	3	0	1
L:L:S14	R:R:F184	2.64	1	No	Yes	0	6	0	1
R:R:E177	R:R:T178	1.41	0	No	No	1	3	1	2
L:L:R21	R:R:N176	1.21	0	No	No	0	3	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7VVJ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.53
Number of Linked Nodes	372
Number of Links	440
Number of Hubs	68
Number of Links mediated by Hubs	247
Number of Communities	9
Number of Nodes involved in Communities	83
Number of Links involved in Communities	126

Path Summary
Number Of Nodes in MetaPath	81
Number Of Links MetaPath	80
Number of Shortest Paths	134461
Length Of Smallest Path	3
Average Path Length	19.0678
Length of Longest Path	48
Minimum Path Strength	1.095
Average Path Strength	7.22026
Maximum Path Strength	29.595
Minimum Path Correlation	0.7
Average Path Correlation	0.96479
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.33333
Average % Of Corr. Nodes	64.2701
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.314
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • protein binding • binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to stimulus • response to stimulus • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to stress • response to chemical • response to oxygen levels • response to abiotic stimulus • cellular process • cell population proliferation • regulation of biological process • regulation of cellular process • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • cell projection membrane • synapse • cell junction • cell body • G-protein beta-subunit binding • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • molecular transducer activity • molecular function activator activity • signaling receptor binding • signaling receptor activity • signaling receptor activator activity • hormone activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • peptide hormone receptor binding • hormone receptor binding • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • ossification • bone mineralization • biomineral tissue development • tissue development • multi-multicellular organism process • reproductive process • female pregnancy • multi-organism reproductive process • negative regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • skeletal system development • regulation of chondrocyte differentiation • regulation of cartilage development • regulation of developmental process • cellular developmental process • connective tissue development • negative regulation of cartilage development • cell development • regulation of cell differentiation • negative regulation of chondrocyte differentiation • negative regulation of chondrocyte development • regulation of cell development • regulation of chondrocyte development • cell differentiation • negative regulation of cell differentiation • regulation of multicellular organismal process • regulation of multicellular organismal development • negative regulation of developmental process • negative regulation of cell development • chondrocyte differentiation • negative regulation of multicellular organismal process • chondrocyte development • cartilage development • regulation of biosynthetic process • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • regulation of metabolic process • epidermis development • cell-cell signaling • nucleoside phosphate metabolic process • ribose phosphate metabolic process • cAMP metabolic process • cyclic purine nucleotide metabolic process • carbohydrate derivative metabolic process • primary metabolic process • nucleotide metabolic process • cyclic nucleotide metabolic process • purine-containing compound metabolic process • nucleobase-containing compound metabolic process • purine nucleotide metabolic process • ribonucleotide metabolic process • organophosphate metabolic process • nucleobase-containing small molecule metabolic process • phosphate-containing compound metabolic process • small molecule metabolic process • purine ribonucleotide metabolic process • phosphorus metabolic process • osteoblast development • osteoblast differentiation • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • identical protein binding • protein homodimerization activity • protein dimerization activity • amide binding • peptide hormone binding • hormone binding • peptide receptor activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • transmembrane signaling receptor activity • parathyroid hormone receptor activity • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • embryo development ending in birth or egg hatching • chordate embryonic development • embryo development • in utero embryonic development • anatomical structure maturation • cell maturation • developmental maturation • cell surface receptor signaling pathway • regulation of inositol phosphate biosynthetic process • alcohol metabolic process • positive regulation of phosphate metabolic process • inositol phosphate metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • regulation of phosphate metabolic process • polyol biosynthetic process • regulation of carbohydrate metabolic process • carbohydrate metabolic process • polyol metabolic process • positive regulation of phosphorus metabolic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • carbohydrate biosynthetic process • positive regulation of inositol phosphate biosynthetic process • organophosphate biosynthetic process • inositol phosphate biosynthetic process • alcohol biosynthetic process • regulation of phosphorus metabolic process • positive regulation of carbohydrate metabolic process • regulation of carbohydrate biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • multicellular organismal-level homeostasis • tissue remodeling • bone remodeling • anatomical structure homeostasis • tissue homeostasis • bone resorption • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • intracellular membraneless organelle • nucleolus • membraneless organelle • apical part of cell • apical plasma membrane • basal part of cell • basal plasma membrane • basolateral plasma membrane • receptor complex
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q03431
Sequence	>7VVJ_nogp_Chain_R V M T K E E Q I F L L H R A Q A Q C E K R L R P C L P E W D H I L C W P L G A P G E V V A V P C P D Y I Y D F N H K G H A Y R R C D R N G S W E L V P G H N R T W A N Y S E C V K N E T R E R E V F D R L G M I Y T V G Y S V S L A S L T V A V L I L A Y F R R L H C T R N Y I H M H L F L S F M L R A V S I F V K D A V L Y S G A G Y A G C R V A V T F F L Y F L A T N Y Y W I L V E G L Y L H S L I F M A F F S E K K Y L W G F T V F G W G L P A V F V A V W V S V R A T L A N T G C W D L S S G N K K W I I Q V P I L A S I V L N F I L F I N I V R V L A T K L R E T N A G R C D T R Q Q Y R K L L K S T L V L M P L F G V H Y I V F M A T P Y T E V S G T L W Q V Q M H Y E M L F N S F Q G F F V A I I Y C F C N G E V Q A E I K K S W S R W T L A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9JR3	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-10-16	To be published
	9JR3 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2024-10-16	To be published
	9JR2	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-10-16	To be published
	9JR2 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2024-10-16	To be published
	8JR9	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371	chim(NtGi1-Gs)/β1/γ2	2.57	2023-08-02	10.1038/s41586-023-06467-w
	8JR9 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371		2.57	2023-08-02	10.1038/s41586-023-06467-w
	7Y36	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Teriparatide	-	Gs/β1/γ2	2.8	2023-07-05	To be published
	7Y36 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Teriparatide	-		2.8	2023-07-05	To be published
	7Y35	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/β1/γ2	2.9	2023-07-05	To be published
	7Y35 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-		2.9	2023-07-05	To be published
	8GW8	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	KHF	Gs/β1/γ2	2.9	2023-06-14	10.1038/s41586-023-06169-3
	8GW8 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	KHF		2.9	2023-06-14	10.1038/s41586-023-06169-3
	8FLU	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-	Gs/β1/γ2	2.76	2023-04-26	10.1016/j.str.2023.04.002
	8FLU (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-		2.76	2023-04-26	10.1016/j.str.2023.04.002
	8FLT	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	M-PTH(1-14)	-	Gs/β1/γ2	3.03	2023-04-26	10.1016/j.str.2023.04.002
	8FLT (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	M-PTH(1-14)	-		3.03	2023-04-26	10.1016/j.str.2023.04.002
	8FLS	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/β1/γ2	3.09	2023-04-26	10.1016/j.str.2023.04.002
	8FLS (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-		3.09	2023-04-26	10.1016/j.str.2023.04.002
	8FLR	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/β1/γ2	2.94	2023-04-26	10.1016/j.str.2023.04.002
	8FLR (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		2.94	2023-04-26	10.1016/j.str.2023.04.002
	8FLQ	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.55	2023-04-26	10.1016/j.str.2023.04.002
	8FLQ (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.55	2023-04-26	10.1016/j.str.2023.04.002
	8HAO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/β1/γ2	3.76	2022-12-21	10.1038/s41401-022-01032-z
	8HAO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.76	2022-12-21	10.1038/s41401-022-01032-z
	8HAF	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	chim(NtGi1-Gs)/β1/γ2	3.25	2022-12-21	10.1038/s41401-022-01032-z
	8HAF (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		3.25	2022-12-21	10.1038/s41401-022-01032-z
	8HA0	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/β1/γ2	2.62	2022-12-21	10.1038/s41401-022-01032-z
	8HA0 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.62	2022-12-21	10.1038/s41401-022-01032-z
	7VVO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	4.1	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		4.1	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVN	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.8	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVN (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.8	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVM	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.2	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVM (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.2	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVL	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.8	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVL (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVK	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.3	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVK (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.3	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVJ	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/β1/γ2	3.2	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVJ (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		3.2	2022-08-03	10.1016/j.molcel.2022.07.003
	6NBI	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	4	2019-04-17	10.1126/science.aav7942
	6NBI (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		4	2019-04-17	10.1126/science.aav7942
	6NBH	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	3.5	2019-04-17	10.1126/science.aav7942
	6NBH (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		3.5	2019-04-17	10.1126/science.aav7942
	6NBF	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	3	2019-04-17	10.1126/science.aav7942
	6NBF (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		3	2019-04-17	10.1126/science.aav7942
	6FJ3	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	-	2.5	2018-11-21	10.1038/s41594-018-0151-4

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