Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Q19 8.6225444
2A:A:Y37 8.9145164
3A:A:K53 6.052509
4A:A:F219 6.712867138
5A:A:F222 9.91627
6A:A:Q227 6.1925429
7A:A:K233 6.315629
8A:A:W234 7.462529
9A:A:F238 11.1025429
10A:A:Y253 7.236508
11A:A:F273 5.21167679
12A:A:W277 12.06476
13A:A:W281 12.09625
14A:A:L289 5.8975479
15A:A:F290 6.96149
16A:A:L291 4.6725478
17A:A:N292 5.495409
18A:A:L296 4.94254176
19A:A:Y311 9.6325406
20A:A:F312 4.726508
21A:A:F315 10.245156
22A:A:Y318 7.4185156
23A:A:P321 4.5275405
24A:A:E330 8.5925403
25A:A:D331 8.7375404
26A:A:V334 5.285404
27A:A:K338 11.8675475
28A:A:Y339 9.495473
29A:A:F340 11.5045157
30A:A:R342 7.358574
31A:A:F345 8.158578
32A:A:I348 5.6425404
33A:A:R356 9.6075402
34A:A:Y358 10.3025404
35A:A:Y360 10.5525408
36A:A:F363 10.78575
37A:A:T364 9.48754149
38A:A:N371 6.3045149
39A:A:R373 5.10754135
40A:A:R374 5.723336144
41A:A:F376 7.616676138
42A:A:R385 11.52754185
43A:A:H387 7.72254118
44A:A:L388 5.23254108
45A:A:Y391 7.76754114
46A:A:L393 5.59254108
47B:B:L14 4.524208
48B:B:R22 7.2775406
49B:B:H54 11.195449
50B:B:K57 11.614529
51B:B:Y59 10.692528
52B:B:W63 7.62507
53B:B:R68 10.0025445
54B:B:V71 4.02498
55B:B:D76 7.484169
56B:B:K78 5.4575408
57B:B:L79 5.324597
58B:B:I80 9.3475448
59B:B:W82 14.4075449
60B:B:D83 8.9525448
61B:B:T86 7.1725446
62B:B:N88 9.7775447
63B:B:K89 7.05667649
64B:B:H91 7.74495
65B:B:I93 7.0775407
66B:B:L95 4.936598
67B:B:W99 9.86667629
68B:B:M101 6.1175429
69B:B:Y105 4.70333696
70B:B:Y111 6.7475404
71B:B:V112 4.1875498
72B:B:C114 5.38498
73B:B:Y124 5.425696
74B:B:L126 4.6975495
75B:B:E138 4.7475406
76B:B:H142 7.926529
77B:B:Y145 7.88428728
78B:B:F151 5.98333609
79B:B:Q156 6.035455
80B:B:T159 5.18629
81B:B:S160 5.2456
82B:B:D163 8.302529
83B:B:C166 4.16458
84B:B:L168 5.886556
85B:B:W169 7.85833628
86B:B:F180 8.69557
87B:B:H183 9.04659
88B:B:V187 4.6625459
89B:B:L190 5.12455
90B:B:F199 8.89559
91B:B:V200 8.88466
92B:B:S201 5.2625459
93B:B:C204 6.18427
94B:B:D205 6.618559
95B:B:K209 12.2075456
96B:B:L210 7.265405
97B:B:W211 9.025658
98B:B:D212 5.744249
99B:B:Q220 9.8025467
100B:B:F222 8.758568
101B:B:H225 9.42286769
102B:B:D228 9.7575429
103B:B:I232 5.09468
104B:B:F235 8.067147126
105B:B:P236 6.0154127
106B:B:N237 8.45254125
107B:B:F241 8.848566
108B:B:T243 7.685468
109B:B:D246 5.548529
110B:B:D247 9.67469
111B:B:T249 7.9025466
112B:B:R251 12.026568
113B:B:F253 7.505666
114B:B:R256 8.785409
115B:B:D258 9.408567
116B:B:M262 6.1375404
117B:B:Y264 8.112505
118B:B:I273 6.19426
119B:B:F278 5.995717127
120B:B:R283 7.6145219
121B:B:L286 4.525407
122B:B:Y289 6.56857727
123B:B:D290 6.948526
124B:B:C294 4.945485
125B:B:H311 8.57689
126B:B:R314 16.362528
127B:B:L318 5.4025486
128B:B:W332 11.2457729
129B:B:D333 8.2875489
130B:B:K337 9.038586
131B:B:W339 8.93689
132B:B:N340 8.7625449
133G:G:Y40 11.27254126
134G:G:D48 5.488509
135G:G:P60 7.955449
136G:G:F61 7.23571748
137L:L:E4 5.232510
138L:L:H5 11.715410
139L:L:Q6 7.562510
140L:L:H9 10.054510
141L:L:R20 8.0654250
142L:L:I31 9.0875430
143R:R:C48 5.9325408
144R:R:W112 8.66254267
145R:R:I115 6.376535
146R:R:L116 6.2435
147R:R:W118 10.4325439
148R:R:V129 4.2825435
149R:R:P132 6.795439
150R:R:I135 9.465437
151R:R:F138 9.10333634
152R:R:Y145 6.6075434
153R:R:R146 9.40167638
154R:R:W154 7.30667639
155R:R:W164 4.7575435
156R:R:N166 6.98537
157R:R:Y167 7.43857735
158R:R:E180 5.1975403
159R:R:F184 5.39416
160R:R:L187 4.9125415
161R:R:Y191 6.548507
162R:R:Y195 5.18429717
163R:R:L202 4.316519
164R:R:F212 7.3625277
165R:R:L215 5.2654279
166R:R:R219 6.925119
167R:R:H223 6.82754119
168R:R:F230 8.76667618
169R:R:R233 8.02429718
170R:R:I237 4.84417
171R:R:D241 5.94408
172R:R:F288 7.49407
173R:R:L289 6.408517
174R:R:Y290 6.356519
175R:R:F291 8.45405
176R:R:N295 11.725418
177R:R:Y296 9.07617
178R:R:Y297 6.736516
179R:R:W298 9.88714719
180R:R:I299 5.105419
181R:R:L300 5.9575408
182R:R:E302 11.08409
183R:R:Y305 8.3065118
184R:R:F311 9.48754296
185R:R:F314 9.14407
186R:R:W329 9.865419
187R:R:L331 5.4325414
188R:R:P332 4.10333619
189R:R:F335 8.895415
190R:R:W339 6.44333618
191R:R:R343 9.2325418
192R:R:W352 11.44518
193R:R:D353 8.1725405
194R:R:K359 6.12513
195R:R:K360 7.3517
196R:R:W361 7.1575418
197R:R:Q364 8.828517
198R:R:F378 7.388336109
199R:R:K388 8.33254189
200R:R:L413 6.2654109
201R:R:F417 7.2645109
202R:R:H420 10.5067618
203R:R:Y421 12.185618
204R:R:F424 6.658517
205R:R:M425 3.715406
206R:R:T427 5.4025415
207R:R:Y429 9.87516
208R:R:V432 7.845415
209R:R:W437 8.165815
210R:R:Q440 8.0125416
211R:R:M441 9.7075416
212R:R:Y443 7.794514
213R:R:N448 8.658516
214R:R:F450 6.135417
215R:R:Q451 6.966519
216R:R:F453 7.0625406
217R:R:Y459 9.0775408
218R:R:C460 4.2575409
219R:R:N463 5.98254199
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:I80 B:B:K78 24.96684.36YesYes088
2B:B:D76 B:B:K78 44.44524.15YesYes098
3A:A:Y37 B:B:D76 46.60724.6YesYes1649
4A:A:R42 A:A:Y37 50.216521.61NoYes094
5A:A:F222 A:A:R42 50.57664.28YesNo079
6A:A:F222 B:B:W99 52.508423.05YesYes279
7B:B:Q75 B:B:W99 53.7024.38NoYes299
8B:B:K57 B:B:Q75 26.72769.49YesNo299
9B:B:K57 B:B:W332 27.073818.57YesYes299
10A:A:W281 B:B:W332 28.0025.62YesYes259
11A:A:W281 B:B:D290 39.08518.93YesYes256
12B:B:C271 B:B:D290 97.68623.11NoYes256
13B:B:C271 B:B:Y289 97.69614.03NoYes257
14B:B:W297 B:B:Y289 98.72165.79NoYes287
15B:B:W297 B:B:Y264 99.14716.4NoYes085
16B:B:L252 B:B:Y264 50.05737.03NoYes075
17B:B:F278 B:B:L252 50.13194.87YesNo077
18B:B:F235 B:B:F278 50.43639.65YesYes1267
19B:B:F235 B:B:G282 50.14934.52YesNo1269
20B:B:G282 B:B:S281 1003.71NoNo099
21B:B:S281 G:G:D48 99.98155.89NoYes099
22G:G:D48 G:G:L50 99.6695.43YesNo099
23B:B:V327 G:G:L50 99.65014.47NoNo069
24B:B:L286 B:B:V327 99.47055.96YesNo076
25B:B:C294 B:B:L286 99.82163.17YesYes057
26B:B:C294 B:B:G288 49.55793.92YesNo857
27B:B:G288 B:B:V315 49.5713.68NoNo077
28B:B:H311 B:B:V315 49.54134.15YesNo097
29B:B:D333 B:B:H311 99.03527.56YesYes899
30B:B:D312 B:B:D333 98.86589.31NoYes059
31B:B:D312 R:R:R214 98.795217.87NoNo057
32R:R:E469 R:R:R214 98.724712.79NoNo097
33R:R:E469 R:R:L215 98.32993.98NoYes2799
34R:R:E465 R:R:L215 97.90595.3NoYes099
35R:R:E465 R:R:R219 97.56253.49NoYes099
36R:R:H223 R:R:R219 78.67577.9YesYes1199
37B:B:Q75 B:B:Y59 27.326319.16NoYes298
38B:B:W332 B:B:Y59 27.83729.65YesYes298
39B:B:R314 B:B:W332 27.933622.99YesYes289
40B:B:D290 B:B:R314 28.090816.68YesYes268
41B:B:L285 B:B:Y264 49.9783.52NoYes065
42B:B:F278 B:B:L285 50.001613.4YesNo1276
43B:B:F278 B:B:P236 49.85814.33YesYes1277
44B:B:G282 B:B:P236 49.86944.06NoYes1297
45B:B:C294 B:B:L308 50.16459.52YesNo857
46B:B:L308 B:B:W339 50.094317.08NoYes879
47B:B:H311 B:B:W339 49.51933.17YesYes899
48A:A:Y391 R:R:R219 18.043113.38YesYes1149
49A:A:H387 R:R:L309 10.139116.71YesNo1188
50A:A:K233 B:B:Y145 29.20343.58YesYes298
51A:A:K233 B:B:D246 29.41815.53YesYes299
52A:A:K280 A:A:W281 10.27617.4NoYes055
53A:A:K280 A:A:R283 10.1844.95NoNo053
54A:A:R283 A:A:R356 10.09212.79NoYes032
55B:B:G162 B:B:Y145 27.87558.69NoYes298
56B:B:G162 B:B:S161 27.80093.71NoNo299
57B:B:H142 B:B:S161 27.16115.34YesNo299
58B:B:H142 B:B:T159 24.32176.85YesYes299
59B:B:C149 B:B:T159 21.85643.38NoYes089
60B:B:C149 B:B:T102 21.76426.76NoNo088
61B:B:C148 B:B:T102 21.6723.38NoNo068
62B:B:C148 B:B:L190 20.26046.35NoYes565
63B:B:L168 B:B:V213 17.56292.98YesNo064
64B:B:R214 B:B:V213 17.37496.54NoNo094
65B:B:D212 B:B:R214 17.18683.57YesNo099
66B:B:D212 B:B:L198 16.43435.43YesNo093
67B:B:L198 B:B:L210 16.24628.3NoYes035
68B:B:F199 B:B:L190 10.18013.65YesYes595
69B:B:K78 B:B:P94 18.1015.02YesNo085
70B:B:I93 B:B:P94 17.73943.39YesNo075
71B:B:I93 B:B:Y124 10.13768.46YesYes076
72R:R:E302 R:R:H223 70.751712.31YesYes099
73R:R:E302 R:R:L226 62.939115.9YesNo099
74R:R:F230 R:R:L226 62.86147.31YesNo089
75R:R:F230 R:R:N295 54.360718.12YesYes188
76R:R:N295 R:R:R233 56.224315.67YesYes188
77L:L:E4 R:R:R233 18.0713.49YesYes108
78R:R:R233 R:R:Y195 36.23366.17YesYes187
79L:L:E4 R:R:I237 17.84664.1YesYes107
80R:R:I237 R:R:Y195 17.85526.04YesYes177
81R:R:I222 R:R:W298 15.03493.52NoYes099
82R:R:D241 R:R:I237 34.86614.2YesYes087
83R:R:D241 R:R:Y245 51.81693.45YesNo084
84R:R:D353 R:R:Y245 49.561710.34YesNo054
85R:R:Y191 R:R:Y195 17.68053.97YesYes077
86R:R:D241 R:R:Y191 17.43569.2YesYes087
87L:L:G12 R:R:D353 47.9533.35NoYes005
88L:L:G12 R:R:L354 47.69951.71NoNo005
89L:L:Q16 R:R:L354 47.44611.98NoNo005
90L:L:Q16 R:R:V31 46.68541.43NoNo006
91L:L:K13 R:R:V31 46.43196.07NoNo006
92L:L:D17 L:L:K13 46.17835.53NoNo000
93L:L:D17 L:L:R20 45.92478.34NoYes000
94L:L:R20 R:R:Q37 43.89815.84YesNo007
95R:R:I135 R:R:Q37 43.64448.23YesNo077
96R:R:I135 R:R:P132 25.52485.08YesYes379
97R:R:I115 R:R:P132 15.31543.39YesYes359
98R:R:F138 R:R:I135 16.846318.84YesYes347
99R:R:F138 R:R:I115 15.31895.02YesYes345
100R:R:I115 R:R:Y167 25.528813.3YesYes355
101R:R:R146 R:R:Y167 15.83485.14YesYes385
102R:R:R146 R:R:W154 21.45368YesYes389
103R:R:L109 R:R:W154 16.85794.56NoYes059
104R:R:L109 R:R:P110 16.09183.28NoNo056
105B:B:D290 B:B:G272 30.36631.68YesNo064
106B:B:I80 B:B:W82 15.559414.09YesYes489
107B:B:D246 B:B:G272 30.27691.68YesNo094
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:V2 R:R:Y296 3.79 0 No Yes 0 7 0 1
L:L:V2 R:R:Q364 10.03 0 No Yes 0 7 0 1
L:L:S3 R:R:E444 11.5 0 No No 0 7 0 1
L:L:E4 R:R:Y195 7.86 1 Yes Yes 0 7 0 1
L:L:E4 R:R:R233 3.49 1 Yes Yes 0 8 0 1
L:L:E4 R:R:I237 4.1 1 Yes Yes 0 7 0 1
L:L:E4 R:R:M445 6.77 1 Yes No 0 6 0 1
L:L:E4 R:R:N448 3.94 1 Yes Yes 0 6 0 1
L:L:H5 R:R:L289 11.57 1 Yes Yes 0 7 0 1
L:L:H5 R:R:Q364 11.13 1 Yes Yes 0 7 0 1
L:L:Q6 R:R:Y429 12.4 1 Yes Yes 0 6 0 1
L:L:Q6 R:R:W437 4.38 1 Yes Yes 0 5 0 1
L:L:Q6 R:R:Q440 6.4 1 Yes Yes 0 6 0 1
L:L:Q6 R:R:M441 6.8 1 Yes Yes 0 6 0 1
L:L:L7 R:R:L187 4.15 0 No Yes 0 5 0 1
L:L:L8 R:R:D353 10.86 1 No Yes 0 5 0 1
L:L:H9 R:R:S355 9.76 1 Yes No 0 7 0 1
L:L:H9 R:R:K360 6.55 1 Yes Yes 0 7 0 1
L:L:H9 R:R:Y429 9.8 1 Yes Yes 0 6 0 1
L:L:D10 R:R:V432 5.84 1 No Yes 0 5 0 1
L:L:D10 R:R:W437 8.93 1 No Yes 0 5 0 1
L:L:K11 R:R:F184 3.72 0 No Yes 0 6 0 1
L:L:K11 R:R:Y245 16.72 0 No No 0 4 0 1
L:L:G12 R:R:D353 3.35 0 No Yes 0 5 0 1
L:L:K13 R:R:V31 6.07 0 No No 0 6 0 1
L:L:S14 R:R:F184 5.28 0 No Yes 0 6 0 1
L:L:I15 R:R:R181 6.26 0 No No 0 3 0 1
L:L:Q16 R:R:T33 7.09 0 No No 0 7 0 1
L:L:Q16 R:R:L354 11.98 0 No No 0 5 0 1
L:L:R20 R:R:Q37 5.84 25 Yes No 0 7 0 1
L:L:R20 R:R:Y136 6.17 25 Yes No 0 4 0 1
L:L:R20 R:R:D137 11.91 25 Yes No 0 5 0 1
L:L:R21 R:R:D137 7.15 0 No No 0 5 0 1
L:L:F23 R:R:K34 7.44 3 No No 0 4 0 1
L:L:F23 R:R:I38 6.28 3 No No 0 7 0 1
L:L:L24 R:R:I135 5.71 3 No Yes 0 7 0 1
L:L:L24 R:R:F138 6.09 3 No Yes 0 4 0 1
L:L:I28 R:R:F138 6.28 3 No Yes 0 4 0 1
L:L:I31 R:R:D113 12.59 3 Yes No 0 9 0 1
L:L:I31 R:R:I115 5.89 3 Yes Yes 0 5 0 1
L:L:I31 R:R:Y167 9.67 3 Yes Yes 0 5 0 1
L:L:H32 R:R:N166 12.75 3 No Yes 0 7 0 1
L:L:H32 R:R:Y167 9.8 3 No Yes 0 5 0 1
L:L:H32 R:R:S168 5.58 3 No No 0 6 0 1
R:R:M32 R:R:Y136 3.59 0 No No 6 4 2 1
R:R:E35 R:R:T33 7.06 0 No No 5 7 2 1
R:R:I38 R:R:K34 5.82 3 No No 7 4 1 1
R:R:I135 R:R:Q37 8.23 3 Yes No 7 7 1 1
R:R:D113 R:R:R146 7.15 0 No Yes 9 8 1 2
R:R:I115 R:R:L116 4.28 3 Yes Yes 5 5 1 2
R:R:I115 R:R:P132 3.39 3 Yes Yes 5 9 1 2
R:R:F138 R:R:I115 5.02 3 Yes Yes 4 5 1 1
R:R:I115 R:R:Y167 13.3 3 Yes Yes 5 5 1 1
R:R:L116 R:R:W118 4.56 3 Yes Yes 5 9 2 2
R:R:L116 R:R:P132 11.49 3 Yes Yes 5 9 2 2
R:R:R146 R:R:W118 24.99 3 Yes Yes 8 9 2 2
R:R:W118 R:R:Y167 4.82 3 Yes Yes 9 5 2 1
R:R:I135 R:R:P132 5.08 3 Yes Yes 7 9 1 2
R:R:F138 R:R:P132 7.22 3 Yes Yes 4 9 1 2
R:R:F138 R:R:I135 18.84 3 Yes Yes 4 7 1 1
R:R:D137 R:R:Y136 5.75 25 No No 5 4 1 1
R:R:C170 R:R:F138 11.17 0 No Yes 9 4 2 1
R:R:A144 R:R:Y167 4 0 No Yes 7 5 2 1
R:R:N166 R:R:Y145 8.14 3 Yes Yes 7 4 1 2
R:R:E169 R:R:Y145 12.35 3 No Yes 5 4 2 2
R:R:A165 R:R:R146 4.15 3 No Yes 7 8 2 2
R:R:R146 R:R:Y167 5.14 3 Yes Yes 8 5 2 1
R:R:A165 R:R:Y167 5.34 3 No Yes 7 5 2 1
R:R:N166 R:R:S168 8.94 3 Yes No 7 6 1 1
R:R:E169 R:R:N166 3.94 3 No Yes 5 7 2 1
R:R:L174 R:R:V171 5.96 0 No No 3 3 2 1
R:R:E180 R:R:V432 4.28 0 Yes Yes 3 5 2 1
R:R:D185 R:R:R181 5.96 0 No No 2 3 2 1
R:R:F184 R:R:V432 6.55 1 Yes Yes 6 5 1 1
R:R:F184 R:R:W437 6.01 1 Yes Yes 6 5 1 1
R:R:L187 R:R:W437 3.42 1 Yes Yes 5 5 1 1
R:R:L187 R:R:M441 5.65 1 Yes Yes 5 6 1 1
R:R:H442 R:R:L187 6.43 0 No Yes 5 5 2 1
R:R:I190 R:R:M445 4.37 0 No No 6 6 2 1
R:R:Y191 R:R:Y195 3.97 0 Yes Yes 7 7 2 1
R:R:D241 R:R:Y191 9.2 0 Yes Yes 8 7 2 2
R:R:M445 R:R:Y191 8.38 0 No Yes 6 7 1 2
R:R:R233 R:R:Y195 6.17 1 Yes Yes 8 7 1 1
R:R:A234 R:R:Y195 5.34 0 No Yes 8 7 2 1
R:R:I237 R:R:Y195 6.04 1 Yes Yes 7 7 1 1
R:R:S449 R:R:Y195 3.82 1 No Yes 9 7 2 1
R:R:L292 R:R:R233 9.72 1 No Yes 6 8 2 1
R:R:N295 R:R:R233 15.67 1 Yes Yes 8 8 2 1
R:R:R233 R:R:Y296 13.38 1 Yes Yes 8 7 1 1
R:R:R233 R:R:Y421 4.12 1 Yes Yes 8 8 1 2
R:R:N448 R:R:R233 3.62 1 Yes Yes 6 8 1 1
R:R:D241 R:R:I237 4.2 0 Yes Yes 8 7 2 1
R:R:F288 R:R:I237 5.02 0 Yes Yes 7 7 2 1
R:R:D241 R:R:Y245 3.45 0 Yes No 8 4 2 1
R:R:D353 R:R:L244 8.14 0 Yes No 5 5 1 2
R:R:D353 R:R:Y245 10.34 0 Yes No 5 4 1 1
R:R:F288 R:R:L289 6.09 0 Yes Yes 7 7 2 1
R:R:L289 R:R:W339 5.69 1 Yes Yes 7 8 1 2
R:R:I363 R:R:L289 5.71 1 No Yes 7 7 2 1
R:R:L292 R:R:Y296 5.86 1 No Yes 6 7 2 1
R:R:I367 R:R:Y296 9.67 0 No Yes 7 7 2 1
R:R:I371 R:R:Y296 4.84 1 No Yes 7 7 2 1
R:R:Y296 R:R:Y421 16.88 1 Yes Yes 7 8 1 2
R:R:I363 R:R:W339 14.09 1 No Yes 7 8 2 2
R:R:K360 R:R:S355 4.59 1 Yes No 7 7 1 1
R:R:K360 R:R:W361 6.96 1 Yes Yes 7 8 1 2
R:R:K360 R:R:Q364 4.07 1 Yes Yes 7 7 1 1
R:R:K360 R:R:Y429 14.33 1 Yes Yes 7 6 1 1
R:R:Q364 R:R:W361 8.76 1 Yes Yes 7 8 1 2
R:R:Q364 R:R:Y429 10.15 1 Yes Yes 7 6 1 1
R:R:I371 R:R:Y421 7.25 1 No Yes 7 8 2 2
R:R:H420 R:R:Y421 20.69 1 Yes Yes 8 8 2 2
R:R:H420 R:R:Y443 3.27 1 Yes Yes 8 4 2 2
R:R:H420 R:R:N448 8.93 1 Yes Yes 8 6 2 1
R:R:N448 R:R:Y421 16.28 1 Yes Yes 6 8 1 2
R:R:F424 R:R:T427 5.19 1 Yes Yes 7 5 2 2
R:R:F424 R:R:Q440 11.71 1 Yes Yes 7 6 2 1
R:R:F424 R:R:Y443 7.22 1 Yes Yes 7 4 2 2
R:R:Q440 R:R:T427 8.5 1 Yes Yes 6 5 1 2
R:R:T430 R:R:W437 3.64 0 No Yes 5 5 2 1
R:R:V432 R:R:W437 14.71 1 Yes Yes 5 5 1 1
R:R:Q438 R:R:W437 3.29 0 No Yes 4 5 2 1
R:R:M441 R:R:W437 20.94 1 Yes Yes 6 5 1 1
R:R:M441 R:R:Q440 5.44 1 Yes Yes 6 6 1 1
R:R:E444 R:R:Y443 3.37 0 No Yes 7 4 1 2
R:R:E444 R:R:N448 10.52 0 No Yes 7 6 1 1
R:R:F238 R:R:Y195 3.09 0 No Yes 7 7 2 1
L:L:I28 R:R:V171 3.07 3 No No 0 3 0 1
L:L:V2 R:R:L368 2.98 0 No No 0 4 0 1
R:R:L289 R:R:V285 2.98 1 Yes No 7 6 1 2
L:L:A1 R:R:Y429 2.67 0 No Yes 0 6 0 1
R:R:H42 R:R:I38 2.65 0 No No 4 7 2 1
L:L:L18 R:R:R181 2.43 0 No No 0 3 0 1
R:R:G357 R:R:S355 1.86 0 No No 6 7 2 1
L:L:G12 R:R:L354 1.71 0 No No 0 5 0 1
L:L:Q16 R:R:V31 1.43 0 No No 0 6 0 1
R:R:N166 R:R:W164 1.13 3 Yes Yes 7 5 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
77.78Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
75.00Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
71.43Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
66.67Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
66.67Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
66.67Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
64.29Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
64.29Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
64.29Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
64.29Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
63.33Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
62.96Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
61.54Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
60.71Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
60.71Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
60.00Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
59.26Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
57.14Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
57.14Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
57.14Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
57.14Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
56.67Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
55.17Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
53.57Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
53.57Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
53.33Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
53.33Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
53.33Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
51.72Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
51.72Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
51.72Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
51.61Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
51.52Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
50.00Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
50.00Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
50.00Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
48.48Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
48.39Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
48.28Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
48.28Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
48.15Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
47.22Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
46.67Single6FJ3PTH6FJ3-PTH1-PTH
46.67Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
46.67Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
46.43Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
45.16Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
45.16Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
45.16Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
44.83Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
44.83Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
44.83Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
44.83Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
44.83Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
44.12Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
44.12Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
43.75Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
43.75Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
43.33Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
43.33Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
41.94Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
41.94Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
41.67Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
41.38Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
41.18Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
40.62Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
40.62Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
40.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
40.00Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
40.00Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
40.00Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
39.39Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
39.39Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
39.39Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
39.29Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
38.89Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
38.89Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
38.71Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
38.71Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
37.04Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
37.04Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
36.67Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
36.36Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
36.36Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
35.48Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
35.48Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
35.29Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
35.14Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
34.48Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
33.33Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
33.33Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
33.33Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
33.33Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
33.33Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
32.14Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
31.71Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
31.43Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
31.43Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
31.03Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
30.56Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
30.56Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
28.57Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
28.57Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
26.92Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
26.92Single9B9ZA1AKO9B9Z-CB1-A1AKO
26.67Single5EE7MK08935EE7-Glucagon-MK0893
25.00Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
25.00Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
25.00Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
25.00Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
25.00Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
25.00Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
24.14Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
24.14Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
24.00Single5U09Taranabant5U09-CB1-Taranabant
24.00Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
23.53Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
23.53Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.08Single7T32ZM-2413857T32-A2A-ZM-241385
23.08Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
22.86Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
22.86Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
22.73Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
22.58Single4UG2CGS216804UG2-A2A-CGS21680
22.58Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
22.58Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
22.58Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
22.22Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
22.22Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
22.22Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
21.88Single7QA8Peptide7QA8-STE2-Peptide
21.88Single7QA8Peptide7QA8-STE2-Peptide
21.88Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
21.88Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
21.88Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
21.88Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
21.62Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
21.62Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
21.62Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
21.43Single4JKVTaladegib4JKV-SMO-Taladegib
21.43Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
21.43Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
21.43Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
21.43Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
21.21Single3QAKUK-4320973QAK-A2A-UK-432097
21.21Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
21.21Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
20.69Single5V56TC1145V56-SMO-TC114
20.69Single5V57TC1145V57-SMO-TC114
20.69Single5XRAAM115425XRA-CB1-AM11542
20.69Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
20.69Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
20.69Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
20.69Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
20.69Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
20.69Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
20.59Single5WF5UK-4320975WF5-A2A-UK-432097
20.59Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
20.51Single6IGKEndothelin-36IGK-ETB-Endothelin-3
20.51Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
20.00Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
20.00Single4XEENeurotensin4XEE-NTS1-Neurotensin
20.00Single4XESNeurotensin4XES-NTS1-Neurotensin
20.00Single6KQICP559406KQI-CB1-CP55940-Org27569
20.00Single6LI0C176LI0-GPR52-C17
20.00Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
20.00Single6OS2TRV0266OS2-AT1-TRV026
20.00Single6YVRNTS8-136YVR-NTS1-NTS8-13
20.00Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
20.00Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
20.00Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
20.00Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
20.00Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
20.00Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
20.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
20.00Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
20.00Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
20.00Single9B9Y7DY9B9Y-CB1-7DY
20.00Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
20.00Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
20.00Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
20.00Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
20.00Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
20.00Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
20.00Consensuslpa_offOrthosteric Ligandlpa1_off
20.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
20.00Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
20.00Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
19.44Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
19.44Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
19.44Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
19.44Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
19.44Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
19.44Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
19.35Single4BUONeurotensin4BUO-NTS1-Neurotensin
19.35Single7EZCUKA7EZC-A2A-UKA
19.35Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
19.35Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
19.35Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
19.35Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
19.35Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
19.35Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
19.35Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
19.35Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
19.35Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
19.35Single8XVUCXCL28XVU-CXCR2-CXCL2
19.35Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
19.35Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
19.35Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
19.35Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
19.35Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
19.35Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Single4BWBNeurotensin4BWB-NTS1-Neurotensin
19.23Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
19.23Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
19.23Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
19.23Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
19.23Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
19.23Single9BA0A1AKN9BA0-CB1-A1AKN
18.92Single4XT3Fractalkine4XT3-US28-Fractalkine
18.92Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
18.92Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
18.92Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
18.92Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
18.92Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
18.75Single3NY9ICI118-5513NY9-β2-ICI118-551
18.75Single5WF6UK-4320975WF6-A2A-UK-432097
18.75Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
18.75Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
18.75Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
18.75Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
18.75Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
18.75Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
18.75Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single8QJ2pN1628QJ2-MC4-pN162-Gs
18.75Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
18.75Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
18.52Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
18.52Single5IU7Q274563465IU7-A2A-Q27456346-Na
18.52Single5IUBQ274563445IUB-A2A-Q27456344-Na
18.52Single5JTBZM-2413855JTB-A2A-ZM-241385
18.52Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
18.52Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
18.52Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
18.52Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
18.52Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
18.52Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
18.52Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
18.52Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
18.52Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
18.52Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
18.52Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
18.52Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
18.52Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
18.52Consensusa2_offOrthosteric Liganda2a_off
18.52Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
18.52Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
18.52Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
18.52Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
18.52Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
18.42Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
18.42Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
18.42Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
18.42Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
18.42Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
18.42Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
18.18Single4XT1Fractalkine4XT1-US28-Fractalkine
18.18Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
18.18Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
18.18Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
18.18Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
18.18Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
18.18Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
18.18Single8WDTphotoNECA8WDT-A2A-photoNECA
18.18Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
18.18Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
18.18Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
18.18Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
18.18Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
18.18Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
18.18Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
17.95Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
17.95Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
17.95Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
17.86Single3EMLZM-2413853EML-A2A-ZM-241385
17.86Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
17.86Single5IU8Q274563475IU8-A2A-Q27456347-Na
17.86Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
17.86Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
17.86Single5TGZAM65385TGZ-CB1-AM6538
17.86Single5UENDU1725UEN-A1-DU172
17.86Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
17.86Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
17.86Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
17.86Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
17.86Single6S0LZM-2413856S0L-A2A-ZM-241385
17.86Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
17.86Single7PYRPSB-21157PYR-A2A-PSB-2115
17.86Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
17.86Single7V3ZCP559407V3Z-CB1-CP55940
17.86Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
17.86Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
17.86Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
17.86Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
17.86Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
17.86Consensusa3_onOrthosteric Liganda3a_on
17.86Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
17.65Single6HLOAprepitant6HLO-NK1-Aprepitant
17.65Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
17.65Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
17.65Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
17.65Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
17.65Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
17.65Single7XNACYN1548067XNA-SST2-CYN154806
17.65Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
17.65Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
17.65Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
17.65Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
17.65Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
17.65Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
17.65Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
17.65Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
17.65Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
17.50Single5GLHEndothelin-15GLH-ETB-Endothelin-1
17.50Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
17.50Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
17.50Consensusbombesin_onOrthosteric Ligandbb2_on
17.50Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
17.50Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
17.50Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
17.50Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
17.50Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
17.39Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
17.24Single5IUAQ274563485IUA-A2A-Q27456348-Na
17.24Single5N2RPSB-365N2R-A2A-PSB-36-Na
17.24Single5N2SPSB365N2S-A1-PSB36
17.24Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
17.24Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
17.24Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
17.24Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
17.24Single6S0QZM-2413856S0Q-A2A-ZM-241385
17.24Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
17.24Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
17.24Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
17.24Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
17.24Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
17.24Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
17.24Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
17.24Single8GNEKW-63568GNE-A2A-KW-6356-Na
17.24Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
17.24Single8QOTNanobody-E8QOT-μ-Nanobody-E
17.24Single8S4DCMF-0198S4D-Apelin-CMF-019
17.24Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
17.24Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
17.24Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
17.24Consensusa3_on_gpOrthosteric Liganda3a_on_gp
17.24Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
17.24Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
17.24Consensusadenosine_offOrthosteric Liganda1_off a2_off
17.24Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
17.24Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
17.24Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
17.24Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
17.24Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
17.24Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
17.24Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
17.14Single3OE0CVX153OE0-CXCR4-CVX15
17.14Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
17.14Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
17.14Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
17.14Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
17.14Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
17.14Consensusangiotensin_onOrthosteric Ligandat1_on
17.14Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
17.14Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
17.14Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
17.14Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
17.14Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
17.14Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
17.14Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
17.14Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
17.14Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
17.14Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
16.67Single2YDVNECA2YDV-A2A-NECA
16.67Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
16.67Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
16.67Single4BV0Neurotensin4BV0-NTS1-Neurotensin
16.67Single4UHRCGS216804UHR-A2A-CGS21680
16.67Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
16.67Single5G53NECA5G53-A2A-NECA-Gs
16.67Single5XR8AM8415XR8-CB1-AM841
16.67Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
16.67Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
16.67Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
16.67Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
16.67Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
16.67Single7F1TMIP-1a7F1T-CCR5-MIP-1a
16.67Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
16.67Single7FEECP559407FEE-CB1-CP55940-ZCZ011
16.67Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
16.67Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
16.67Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
16.67Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
16.67Single7PX4PSB-21137PX4-A2A-PSB-2113
16.67Single7TUYGSK682753A7TUY-GPR183-GSK682753A
16.67Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
16.67Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
16.67Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
16.67Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
16.67Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
16.67Single8A2OTheophylline8A2O-A2A-Theophylline-Na
16.67Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
16.67Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
16.67Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
16.67Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
16.67Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
16.67Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
16.67Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
16.67Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
16.67Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
16.67Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
16.67Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
16.67Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
16.67Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
16.67Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
16.67Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
16.67Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
16.67Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
16.67Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
16.67Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
16.67Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
16.67Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
16.67Consensuslpa_onOrthosteric Ligandlpa1_on
16.67Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
16.67Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
16.67Consensusneurotensin_onOrthosteric Ligandnts1_on
16.67Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
16.67Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
16.67Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
16.67Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
16.67Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
16.67Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
16.67Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
16.67Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
16.67Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
16.67Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
16.67Consensusvasop-oxy_onOrthosteric Ligandv2_on
16.67Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
16.28Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
16.22Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
16.22Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
16.22Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
16.22Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
16.22Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
16.22Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
16.22Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
16.22Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
16.22Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
16.22Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
16.22Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
16.22Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
16.22Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
16.22Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
16.22Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
16.22Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
16.22Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
16.13Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
16.13Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
16.13Single4N4WSANT-14N4W-SMO-SANT-1
16.13Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
16.13Single6IIURamatroban6IIU-TP-Ramatroban
16.13Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
16.13Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
16.13Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
16.13Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
16.13Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
16.13Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
16.13Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
16.13Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
16.13Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
16.13Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
16.13Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
16.13Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
16.13Single8JWY2-1188JWY-A2A-2-118
16.13Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
16.13Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
16.13Single8XWMCXCL68XWM-CXCR2-CXCL6
16.13Single8XWSCXCL58XWS-CXCR2-CXCL5
16.13Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
16.13Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
16.13Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
16.13Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
16.13Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
16.13Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
16.13Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
16.13Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
16.13Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
16.13Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
16.13Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
16.13Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
16.13Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
16.00Single4XNWMRS25004XNW-P2Y1-MRS2500
16.00Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
16.00Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
16.00Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
16.00Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.00Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
16.00Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
16.00Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
16.00Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
15.79Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
15.79Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
15.79Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
15.79Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
15.79Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
15.79Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
15.79Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
15.62Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
15.62Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
15.62Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
15.62Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
15.62Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
15.62Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
15.62Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
15.62Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
15.62Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
15.62Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
15.62Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
15.62Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
15.62Single8XWFCXCL38XWF-CXCR2-CXCL3
15.62Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
15.62Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
15.62Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
15.62Consensuscck_onOrthosteric Ligandccka_on cckb_on
15.62Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
15.62Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.62Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.62Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
15.62Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
15.62Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
15.62Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
15.62Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
15.62Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
15.56Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
15.56Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
15.38Single5L7IVismodegib5L7I-SMO-Vismodegib
15.38Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
15.38Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
15.38Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
15.38Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
15.38Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
15.38Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
15.38Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
15.38Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
15.38Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
15.38Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
15.15Single5ZTYAM102575ZTY-CB2-AM10257
15.15Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
15.15Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
15.15Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
15.15Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
15.15Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
15.15Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
15.15Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
15.15Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
15.15Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
15.15Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
15.15Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
15.15Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
15.15Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
15.15Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
15.00Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
15.00Single8IY6Endothelin-18IY6-ETB-Endothelin-1
15.00Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Consensusendothelin_onOrthosteric Ligandetb_on eta_on
14.81Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
14.81Single3PWHZM-2413853PWH-A2A-ZM-241385
14.81Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
14.81Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
14.81Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
14.81Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
14.81Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
14.81Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
14.81Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
14.81Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
14.81Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
14.81Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.81Single8GNGIstradefylline8GNG-A2A-Istradefylline
14.81Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
14.81Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
14.81Single8IWESpermidine8IWE-TA9-Spermidine
14.81Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
14.81Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
14.81Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
14.81Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
14.81Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
14.81Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
14.81Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
14.81Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
14.81Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
14.81Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
14.71Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
14.71Single7F8XNN90567F8X-CCKA-NN9056
14.71Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
14.71Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
14.71Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
14.71Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
14.71Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
14.71Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
14.71Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
14.71Single8XWNCXCL88XWN-CXCR2-CXCL8
14.71Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.71Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
14.71Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
14.71Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
14.71Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
14.71Consensuslpl_onOrthosteric Ligands1p_on lpa_on
14.71Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
14.71Consensussomatostatin_offOrthosteric Ligandsst2_off
14.71Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
14.63Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
14.29Single2YDOAdenosine2YDO-A2A-Adenosine
14.29Single5UVIZM-2413855UVI-A2A-ZM-241385
14.29Single6AQFZM-2413856AQF-A2A-ZM-241385
14.29Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
14.29Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
14.29Single6MH8ZM-2413856MH8-A2A-ZM-241385
14.29Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
14.29Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
14.29Single7AROLUF58337ARO-A2A-LUF5833-Na
14.29Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
14.29Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
14.29Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
14.29Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
14.29Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
14.29Single7SK5CXCL127SK5-ACKR3-CXCL12
14.29Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
14.29Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
14.29Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
14.29Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
14.29Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
14.29Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
14.29Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
14.29Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
14.29Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
14.29Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
14.29Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
14.29Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
14.29Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
14.29Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
14.29Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
14.29Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
14.29Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
14.29Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
14.29Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
14.29Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
14.29Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
14.29Consensusgrh_offOrthosteric Ligandgnrh1_off
14.29Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
14.29Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
14.29Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
13.95Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
13.89Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
13.89Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
13.89Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
13.89Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
13.89Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
13.89Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.89Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.89Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
13.89Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
13.89Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
13.89Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
13.89Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
13.89Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
13.89Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
13.89Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Single4DAJTiotropium4DAJ-M3-Tiotropium
13.79Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
13.79Single4QIMANTA XV4QIM-SMO-ANTA XV
13.79Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
13.79Single5DSGTiotropium5DSG-M4-Tiotropium
13.79Single5T04Neurotensin5T04-NTS1-Neurotensin
13.79Single5UIGCmpd-15UIG-A2A-Cmpd-1
13.79Single6D27CAY104716D27-DP2-CAY10471
13.79Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
13.79Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
13.79Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
13.79Single6IIVDaltroban6IIV-TP-Daltroban
13.79Single6PS1Timolol6PS1-β2-Timolol
13.79Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
13.79Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
13.79Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
13.79Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
13.79Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
13.79Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
13.79Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
13.79Single8CU6LJ-45178CU6-A2A-LJ-4517
13.79Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
13.79Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
13.79Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
13.79Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
13.79Single8RLNLUF58348RLN-A2A-LUF5834
13.79Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
13.79Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.79Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
13.79Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
13.79Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
13.79Single9CHXS-Carazolol9CHX-β2-S-Carazolol
13.79Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
13.79Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
13.79Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
13.79Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
13.79Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
13.79Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
13.73Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
13.51Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
13.51Single6JODAngiotensin II6JOD-AT2-Angiotensin II
13.51Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
13.51Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
13.51Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
13.51Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
13.51Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
13.51Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
13.51Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
13.51Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
13.51Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
13.51Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
13.51Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
13.51Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
13.33Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
13.33Single5C1MBU725C1M-μ-BU72
13.33Single5JQHS-Carazolol5JQH-β2-S-Carazolol
13.33Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
13.33Single5TVNLSD5TVN-5-HT2B-LSD
13.33Single6D26Fevipiprant6D26-DP2-Fevipiprant
13.33Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
13.33Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
13.33Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
13.33Single6PS6Timolol6PS6-β2-Timolol
13.33Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
13.33Single7C61Ergotamine7C61-5-HT1B-Ergotamine
13.33Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
13.33Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
13.33Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
13.33Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
13.33Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
13.33Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
13.33Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.33Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
13.33Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
13.33Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.33Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
13.33Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
13.33Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
13.33Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.33Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
13.33Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
13.33Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
13.33Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
13.33Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
13.33Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
13.33Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
13.33Single8TF5Oleic acid8TF5-GPR6-Oleic acid
13.33Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.33Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
13.33Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
13.33Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
13.33Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
13.33Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
13.33Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
13.33Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
13.33Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
13.33Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
13.33Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
13.33Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
13.33Consensusdp_offOrthosteric Liganddp2_off
13.33Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
13.33Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
13.33Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
13.33Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
13.33Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
13.33Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
13.33Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
13.33Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.33Consensustrace-amine_onOrthosteric Ligandta1_on
13.16Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
13.16Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
13.16Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
13.16Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
13.16Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
13.16Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
13.16Single8ZRTET-18ZRT-ETB-ET-1
13.16Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
13.16Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
12.90Single3P0GBI1671073P0G-β2-BI167107
12.90Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
12.90Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
12.90Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
12.90Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
12.90Single5V54Methiothepin5V54-5-HT1B-Methiothepin
12.90Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
12.90Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
12.90Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
12.90Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
12.90Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
12.90Single6OS1TRV0266OS1-AT1-TRV026
12.90Single6WGTLSD6WGT-5-HT2A-LSD
12.90Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
12.90Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
12.90Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
12.90Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
12.90Single7P2L4YI7P2L-mGlu5-4YI
12.90Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
12.90Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
12.90Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
12.90Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
12.90Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
12.90Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
12.90Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.90Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
12.90Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
12.90Single8E0GBU728E0G-μ-BU72
12.90Single8EA0Iperoxo8EA0-M3-Iperoxo
12.90Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
12.90Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
12.90Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
12.90Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
12.90Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
12.90Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
12.90Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
12.90Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
12.90Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
12.90Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
12.90Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
12.90Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
12.90Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
12.90Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
12.90Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
12.90Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
12.90Consensus5ht1_offOrthosteric Ligand5ht1b_off
12.90Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
12.90Consensusa2_onOrthosteric Liganda2b_on
12.90Consensusa2_on_gpOrthosteric Liganda2b_on_gp
12.90Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
12.90Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
12.90Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
12.90Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
12.90Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
12.90Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
12.90Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
12.90Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
12.90Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
12.90Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
12.90Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
12.90Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
12.90Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
12.90Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
12.90Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
12.90Consensusrelaxin_onOrthosteric Ligandrxfp4_on
12.90Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
12.90Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.90Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
12.82Single7SK3CXCL127SK3-ACKR3-CXCL12
12.82Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
12.82Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
12.82Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
12.50Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
12.50Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
12.50Single5CXVTiotropium5CXV-M1-Tiotropium
12.50Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
12.50Single6A93Risperidone6A93-5-HT2A-Risperidone
12.50Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
12.50Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
12.50Single6MXTSalmeterol6MXT-β2-Salmeterol
12.50Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
12.50Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
12.50Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
12.50Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
12.50Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
12.50Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
12.50Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
12.50Single7K15MKD0467K15-BLT1-MKD046-Na
12.50Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
12.50Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
12.50Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
12.50Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
12.50Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
12.50Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
12.50Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
12.50Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8HS2Fab0468HS2-GPR20-Fab046
12.50Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
12.50Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
12.50Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
12.50Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
12.50Single8JJ8Formoterol8JJ8-β2-Formoterol
12.50Single8JJLOlodaterol8JJL-β2-Olodaterol
12.50Single8JWZAB9288JWZ-A2A-AB928-Na
12.50Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
12.50Single8PWNTheophylline8PWN-A2A-Theophylline
12.50Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
12.50Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
12.50Single8XWACXCL18XWA-CXCR2-CXCL1
12.50Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
12.50Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
12.50Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
12.50Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
12.50Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
12.50Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
12.50Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
12.50Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
12.50Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
12.50Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
12.50Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
12.50Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
12.50Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
12.20Single6IGLIRL16206IGL-ETB-IRL1620
12.20Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
12.20Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
12.20Consensusbradykinin_onOrthosteric Ligandbk2_on
12.20Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
12.20Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
12.20Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
12.12Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
12.12Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
12.12Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
12.12Single5CGDHTL142425CGD-mGlu5-HTL14242
12.12Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
12.12Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
12.12Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
12.12Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
12.12Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
12.12Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
12.12Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
12.12Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.12Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
12.12Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
12.12Single7UM4AS26747237UM4-5-HT5A-AS2674723
12.12Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
12.12Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
12.12Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.12Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
12.12Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
12.12Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
12.12Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
12.12Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
12.12Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
12.12Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
12.12Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
12.12Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
12.12Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
12.12Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
12.12Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
12.12Consensuschemerin_onOrthosteric Ligandcml1_on
12.12Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
12.12Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
12.12Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
12.12Consensusprostanoid_offOrthosteric Ligandep_off dp_off
12.00Single3RFMCaffeine3RFM-A2A-Caffeine
12.00Consensusp2y_offOrthosteric Ligandp2y1_off
11.90Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
11.90Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
11.76Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
11.76Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
11.76Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
11.76Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
11.76Single6PT3DPI-2876PT3-δ-DPI-287
11.76Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
11.76Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
11.76Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
11.76Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
11.76Single7XN9L-054,5227XN9-SST2-L-054,522
11.76Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
11.76Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
11.76Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
11.76Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
11.76Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
11.76Single8XQJJN2418XQJ-Apelin-JN241
11.76Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
11.76Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
11.76Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
11.76Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
11.76Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
11.76Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
11.76Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
11.63Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
11.54Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
11.54Single6ME5Agomelatine6ME5-MT1-Agomelatine
11.54Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
11.54Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
11.54Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
11.54Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
11.54Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
11.54Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
11.54Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
11.54Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
11.54Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
11.54Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
11.54Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
11.43Single4IARErgotamine4IAR-5-HT1B-Ergotamine
11.43Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
11.43Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
11.43Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
11.43Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
11.43Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
11.43Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.43Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
11.43Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
11.43Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
11.43Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.43Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
11.43Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
11.43Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
11.11Single3OE9IT1t3OE9-CXCR4-IT1t
11.11Single4O9RCyclopamine4O9R-SMO-Cyclopamine
11.11Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
11.11Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
11.11Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
11.11Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
11.11Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
11.11Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
11.11Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
11.11Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
11.11Single7UL2SR486927UL2-NTS1-SR48692-Na
11.11Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
11.11Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
11.11Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
11.11Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
11.11Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
11.11Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
11.11Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
11.11Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
11.11Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
11.11Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
11.11Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
11.11Single8K5BNiacin8K5B-HCA2-Niacin
11.11Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
11.11Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
11.11Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
11.11Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
11.11Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
11.11Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
11.11Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
11.11Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
11.11Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
11.11Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
11.11Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
11.11Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
11.11Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
11.11Consensusneurotensin_offOrthosteric Ligandnts1_off
11.11Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
11.11Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
11.11Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
11.11Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
11.11Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
10.81Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
10.81Single6PT2KGCHM076PT2-δ-KGCHM07
10.81Single6W25SHU91196W25-MC4-SHU9119-Ca
10.81Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.81Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
10.81Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
10.81Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
10.81Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
10.71Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
10.71Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
10.71Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
10.71Single4QINSAG1.54QIN-SMO-SAG1.5
10.71Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
10.71Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
10.71Single6ME2Ramelteon6ME2-MT1-Ramelteon
10.71Single6ME9Ramelteon6ME9-MT2-Ramelteon
10.71Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
10.71Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
10.71Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
10.71Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
10.71Single7BR3Elagolix7BR3-GnRH1-Elagolix
10.71Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
10.71Single7F8ULintitript7F8U-CCKA-Lintitript
10.71Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
10.71Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
10.71Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
10.71Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
10.71Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
10.71Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
10.71Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
10.71Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
10.71Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
10.71Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
10.71Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
10.71Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
10.71Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.71Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.71Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
10.71Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
10.71Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
10.71Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
10.71Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
10.71Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
10.71Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
10.71Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
10.71Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
10.71Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
10.71Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
10.71Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
10.71Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
10.71Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
10.71Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
10.71Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
10.71Consensusalpha2_offOrthosteric Ligandalpha2c_off
10.71Consensusangiotensin_offOrthosteric Ligandat1_off
10.71Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
10.71Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
10.71Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
10.71Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
10.71Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
10.71Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
10.71Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
10.71Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
10.71Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
10.71Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
10.71Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
10.53Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
10.53Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
10.53Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
10.53Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
10.53Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
10.34Single3REYXAC3REY-A2A-XAC
10.34Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
10.34Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
10.34Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
10.34Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
10.34Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
10.34Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
10.34Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
10.34Single6KUXRS-799486KUX-α2a-RS-79948
10.34Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
10.34Single6PS0S-Carazolol6PS0-β2-S-Carazolol
10.34Single6PS4ICI118-5516PS4-β2-ICI118-551
10.34Single6PS5S-Propranolol6PS5-β2-S-Propranolol
10.34Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
10.34Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
10.34Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
10.34Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
10.34Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
10.34Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
10.34Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
10.34Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
10.34Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
10.34Single7UL3Famotidine7UL3-H2-Famotidine
10.34Single7VV6C48/807VV6-MRGPRX2-C48/80
10.34Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
10.34Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
10.34Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
10.34Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
10.34Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
10.34Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
10.34Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
10.34Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
10.34Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
10.34Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.34Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.34Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.34Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
10.34Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
10.34Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
10.34Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
10.34Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
10.34Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
10.34Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
10.34Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
10.34Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
10.34Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
10.34Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
10.34Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
10.34Single8K2WAMG4878K2W-CXCR3-AMG487
10.34Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.34Single8K5CAcipimox8K5C-HCA2-Acipimox
10.34Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
10.34Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
10.34Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.34Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.34Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
10.34Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
10.34Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
10.34Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
10.34Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
10.34Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
10.34Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
10.34Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
10.34Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
10.34Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
10.34Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
10.34Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
10.34Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
10.34Consensushca_onOrthosteric Ligandhca2_on
10.26Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
10.26Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.26Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
10.26Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
10.00Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
10.00Single2Y01Dobutamine2Y01-β1-Dobutamine
10.00Single2Y02Carmoterol2Y02-β1-Carmoterol
10.00Single2Y04Salbutamol2Y04-β1-Salbutamol
10.00Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
10.00Single3NY8ICI118-5513NY8-β2-ICI118-551
10.00Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
10.00Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
10.00Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
10.00Single4GBRS-Carazolol4GBR-β2-S-Carazolol
10.00Single4MQSIperoxo4MQS-M2-Iperoxo
10.00Single4QKX35V4QKX-β2-35V
10.00Single4U14Tiotropium4U14-M3-Tiotropium
10.00Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
10.00Single4YAYZD-71554YAY-AT1-ZD-7155
10.00Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
10.00Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
10.00Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
10.00Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
10.00Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
10.00Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
10.00Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
10.00Single6GPSMK08126GPS-CCR2-MK0812
10.00Single6H7MSalbutamol6H7M-β1-Salbutamol
10.00Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
10.00Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
10.00Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
10.00Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
10.00Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
10.00Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
10.00Single7BU7BI1671077BU7-β1-BI167107
10.00Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
10.00Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
10.00Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
10.00Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
10.00Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
10.00Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
10.00Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
10.00Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
10.00Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
10.00Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
10.00Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
10.00Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
10.00Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
10.00Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
10.00Single7WC7Lisuride7WC7-5-HT2A-Lisuride
10.00Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
10.00Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
10.00Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
10.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
10.00Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
10.00Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
10.00Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
10.00Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
10.00Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
10.00Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
10.00Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
10.00Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
10.00Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
10.00Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
10.00Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
10.00Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
10.00Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
10.00Single8JJOAlprenolol8JJO-β2-Alprenolol
10.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
10.00Single8JXRLSD8JXR-D1-LSD
10.00Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
10.00Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
10.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
10.00Single8T1WCVN4248T1W-GPR6-CVN424
10.00Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
10.00Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
10.00Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
10.00Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
10.00Single8X63Mepyramine8X63-H1-Mepyramine
10.00Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
10.00Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
10.00Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
10.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
10.00Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
10.00Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
10.00Single9IYAONO-97105319IYA-GPR55-ONO-9710531
10.00Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
10.00Consensus5ht5_onOrthosteric Ligand5ht5a_on
10.00Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
10.00Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
10.00Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
10.00Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
10.00Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
10.00Consensusdopamine_offOrthosteric Ligandd2_off d3_off
10.00Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
10.00Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
10.00Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
10.00Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
10.00Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
10.00Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
10.00Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
10.00Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
10.00Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
10.00Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
10.00Consensushca_on_gpOrthosteric Ligandhca2_on_gp
10.00Consensushistamine_offOrthosteric Ligandh1_off
10.00Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
10.00Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
10.00Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
10.00Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
9.76Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
9.68Single2RH1S-Carazolol2RH1-β2-S-Carazolol
9.68Single2Y00Dobutamine2Y00-β1-Dobutamine
9.68Single2Y03Isoprenaline2Y03-β1-Isoprenaline
9.68Single2YCWS-Carazolol2YCW-β1-S-Carazolol
9.68Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
9.68Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
9.68Single5CGCHTL142425CGC-mGlu5-HTL14242
9.68Single5D6LS-Carazolol5D6L-β2-S-Carazolol
9.68Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
9.68Single5XPRBosentan5XPR-ETB-Bosentan
9.68Single6E67BI1671076E67-β2-BI167107-Gs (fused)
9.68Single6GPXMK08126GPX-CCR2-MK0812
9.68Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
9.68Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
9.68Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
9.68Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
9.68Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
9.68Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
9.68Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
9.68Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
9.68Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
9.68Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
9.68Single7C4SS1P7C4S-S1P3-S1P
9.68Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
9.68Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
9.68Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
9.68Single7SINNPS-21437SIN-CaS-NPS-2143
9.68Single7SINNPS-21437SIN-CaS-NPS-2143
9.68Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
9.68Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
9.68Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
9.68Single7W41PD1762527W41-BB2-PD176252
9.68Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
9.68Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
9.68Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.68Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
9.68Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
9.68Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.68Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.68Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
9.68Single8JXSPF-61428JXS-D1-PF-6142
9.68Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
9.68Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
9.68Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
9.68Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
9.68Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
9.68Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
9.68Single8ZMFA1L108ZMF-5-HT2C-A1L10
9.68Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
9.68Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
9.68Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
9.68Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
9.68Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
9.68Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
9.68Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
9.68Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
9.68Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
9.68Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
9.68Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
9.68Consensusamine_offonOrthosteric Ligandamine_off amine_on
9.68Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
9.68Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
9.68Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
9.68Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
9.68Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
9.68Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
9.68Consensusblt_offOrthosteric Ligandblt1_off
9.68Consensusbombesin_offOrthosteric Ligandbb2_off
9.68Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
9.68Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
9.68Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
9.68Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
9.68Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
9.68Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.68Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.68Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
9.68Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
9.52Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
9.52Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
9.38Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
9.38Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
9.38Single4U15Tiotropium4U15-M3-Tiotropium
9.38Single5D5AS-Carazolol5D5A-β2-S-Carazolol
9.38Single5D5BS-Carazolol5D5B-β2-S-Carazolol
9.38Single5TZRMK86665TZR-FFA1-MK8666
9.38Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
9.38Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
9.38Single6H7JIsoprenaline6H7J-β1-Isoprenaline
9.38Single6J21Aprepitant6J21-NK1-Aprepitant
9.38Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
9.38Single6OL9Tiotropium6OL9-M5-Tiotropium
9.38Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
9.38Single7B6WCyclazosin7B6W-α1b-Cyclazosin
9.38Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
9.38Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
9.38Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
9.38Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
9.38Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
9.38Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
9.38Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
9.38Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
9.38Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
9.38Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
9.38Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
9.38Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
9.38Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
9.38Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
9.38Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
9.38Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
9.38Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
9.38Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
9.38Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
9.38Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
9.38Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
9.38Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
9.38Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
9.38Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
9.38Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
9.38Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
9.38Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
9.38Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
9.38Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
9.38Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
9.38Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
9.38Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
9.38Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
9.38Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
9.38Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
9.38Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
9.38Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
9.38Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
9.38Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
9.38Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
9.38Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
9.38Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
9.38Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
9.38Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
9.38Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
9.09Single3D4STimolol3D4S-β2-Timolol
9.09Single4AMIBucindolol4AMI-β1-Bucindolol
9.09Single4LDEBI1671074LDE-β2-BI167107
9.09Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
9.09Single4PY02MeSATP4PY0-P2Y12-2MeSATP
9.09Single4RWADIPP-NH24RWA-δ-DIPP-NH2
9.09Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
9.09Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
9.09Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
9.09Single6CM4Risperidone6CM4-D2-Risperidone
9.09Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
9.09Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
9.09Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
9.09Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
9.09Single7DFPSpiperone7DFP-D2-Spiperone
9.09Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
9.09Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.09Single7YITNalfurafine7YIT-κ-Nalfurafine
9.09Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
9.09Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
9.09Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
9.09Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
9.09Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
9.09Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
9.09Single8XQJJN2418XQJ-Apelin-JN241
9.09Single8XYIVUF106618XYI-CXCR3-VUF10661
9.09Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
9.09Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
9.09Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
9.09Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
9.09Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
9.09Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
9.09Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
9.09Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
9.09Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
9.09Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
9.09Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
9.09Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
9.09Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
9.09Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
9.09Consensusorexin_onOrthosteric Ligandox2_on
9.09Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
9.09Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.09Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.82Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
8.82Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
8.82Single5X93K-87945X93-ETB-K-8794
8.82Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
8.82Single6H7LDobutamine6H7L-β1-Dobutamine
8.82Single6IBLArformoterol6IBL-β1-Arformoterol
8.82Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
8.82Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
8.82Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
8.82Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
8.82Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
8.82Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.82Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.82Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
8.82Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
8.82Single8XVJMacitentan8XVJ-ETA-Macitentan
8.82Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
8.82Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
8.82Consensusendothelin_offOrthosteric Ligandetb_off
8.82Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
8.82Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
8.82Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
8.57Single6KNMJN241-96KNM-Apelin-JN241-9
8.57Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
8.57Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
8.57Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.57Single7SK9CCX6627SK9-ACKR3-CCX662
8.57Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
8.57Single8X5YAstemizole8X5Y-H1-Astemizole
8.57Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
8.57Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
8.57Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
8.57Consensuskisspeptin_onOrthosteric Ligandkiss1_on
8.57Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
8.57Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
8.33Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
8.33Single5MZPCaffeine5MZP-A2A-Caffeine-Na
8.33Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
8.33Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
8.33Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
8.33Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
8.33Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
8.33Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
8.33Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
8.33Single8IEBA1LYA8IEB-GPR156-A1LYA
8.33Single8IEIA1LYA8IEI-GPR156-A1LYA
8.33Single8IEPA1LYA8IEP-GPR156-A1LYA
8.33Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
8.33Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
8.33Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
8.33Single8WKYPG-9348WKY-MC4-PG-934
8.33Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
8.33Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
8.33Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
8.33Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
8.33Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
8.33Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
8.33Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
8.33Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
8.33Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
8.11Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
8.11Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
8.11Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
8.11Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
8.00Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
8.00Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
8.00Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
7.89Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
7.89Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
7.89Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
7.89Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
7.89Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
7.89Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
7.69Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
7.69Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
7.69Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.69Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.69Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
7.69Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
7.69Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
7.69Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
7.69Single9CHUNoradrenaline9CHU-β2-Noradrenaline
7.41Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
7.41Single3OE6IT1t3OE6-CXCR4-IT1t
7.41Single3UZAGTPL92363UZA-A2A-GTPL9236
7.41Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
7.41Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
7.41Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
7.41Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
7.41Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
7.41Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
7.41Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
7.41Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
7.41Single7V6A-7V6A-M4-PubChem 9864275-Gi1/β1/γ2
7.41Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.41Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.41Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
7.41Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
7.41Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
7.41Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
7.41Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
7.41Single8JPSCCL78JPS-ACKR1-CCL7
7.41Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
7.41Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
7.41Consensus5ht2_onOrthosteric Ligand5ht2b_on
7.41Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.41Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
7.41Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
7.14Single3PBLEticlopride3PBL-D3-Eticlopride
7.14Single6HLLCP999946HLL-NK1-CP99994
7.14Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
7.14Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
7.14Single7SRQLSD7SRQ-5-HT2B-LSD
7.14Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
7.14Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
7.14Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
7.14Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
7.14Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
7.14Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
7.14Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
7.14Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
7.14Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
7.14Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
7.14Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
7.14Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
7.14Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
7.14Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
7.14Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
7.14Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
7.14Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
7.14Consensusgq_nucleotideOrthosteric Ligandgq_p2y
7.14Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
6.90Single3ODUIT1t3ODU-CXCR4-IT1t
6.90Single4S0VSuvorexant4S0V-OX2-Suvorexant
6.90Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
6.90Single5ZKQABT-4915ZKQ-PAF-ABT-491
6.90Single6AKXA4R6AKX-CCR5-A4R
6.90Single6AKYMaraviroc6AKY-CCR5-Maraviroc
6.90Single6DS0Ly2660976DS0-5-HT2B-Ly266097
6.90Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
6.90Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
6.90Single6TPJSuvorexant6TPJ-OX2-Suvorexant
6.90Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
6.90Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
6.90Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
6.90Single7F8YDevazepide7F8Y-CCKA-Devazepide
6.90Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
6.90Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
6.90Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
6.90Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.90Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
6.90Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
6.90Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.90Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
6.90Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
6.90Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
6.90Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
6.90Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
6.90Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
6.90Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
6.90Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
6.90Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
6.90Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
6.90Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.90Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.90Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
6.90Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
6.90Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
6.90Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
6.90Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.90Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.90Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.90Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
6.90Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
6.90Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
6.90Single8Y0HVUF114188Y0H-CXCR3-VUF11418
6.90Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
6.90Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
6.90Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
6.90Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
6.90Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
6.90Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.90Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
6.90Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
6.90Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
6.90Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
6.90Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
6.90Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
6.90Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
6.67Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
6.67Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
6.67Single4MBSMaraviroc4MBS-CCR5-Maraviroc
6.67Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
6.67Single6A94Zotepine6A94-5-HT2A-Zotepine
6.67Single6FFIMMPEP6FFI-mGlu5-MMPEP
6.67Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
6.67Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
6.67Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
6.67Single6TP3Nemorexant6TP3-OX1-Nemorexant
6.67Single6V9SGTPL114036V9S-OX1-GTPL11403
6.67Single6VI4JDTic6VI4-κ-JDTic
6.67Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
6.67Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
6.67Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
6.67Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
6.67Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
6.67Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
6.67Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
6.67Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
6.67Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
6.67Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.67Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
6.67Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
6.67Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
6.67Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
6.67Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
6.67Single8IHKAcifran8IHK-HCA3-Acifran
6.67Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
6.67Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
6.67Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
6.67Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
6.67Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
6.67Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.67Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.67Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
6.67Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
6.67Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
6.67Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
6.67Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
6.67Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
6.67Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
6.67Single9BJKNaloxone9BJK-μ-Naloxone-NAM
6.67Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
6.67Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
6.67Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
6.67Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
6.67Consensusalpha1_onOrthosteric Ligandalpha1a_on
6.67Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
6.67Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
6.67Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
6.67Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
6.67Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
6.67Consensusopsins_offOrthosteric Ligandrhodopsin_off
6.67Consensussensory_offOrthosteric Ligandopsins_off
6.45Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
6.45Single4EJ4Naltrindole4EJ4-δ-Naltrindole
6.45Single5DHHSB-6121115DHH-NOP-SB-612111
6.45Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
6.45Single6DRXLisuride6DRX-5-HT2B-Lisuride
6.45Single6FFHFenobam6FFH-mGlu5-Fenobam
6.45Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
6.45Single6TOTLemborexant6TOT-OX1-Lemborexant
6.45Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.45Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
6.45Single7F83PF-051904577F83-Ghrelin-PF-05190457
6.45Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
6.45Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
6.45Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
6.45Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
6.45Single7UL4Alvimopan7UL4-μ-Alvimopan
6.45Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
6.45Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
6.45Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
6.45Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
6.45Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
6.45Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.45Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
6.45Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
6.45Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
6.45Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
6.45Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
6.45Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
6.45Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
6.45Single8K5DGSK2560738K5D-HCA2-GSK256073
6.45Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
6.45Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
6.45Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
6.45Single8X64Desloratadine8X64-H1-Desloratadine
6.45Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
6.45Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
6.45Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
6.45Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
6.45Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
6.45Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
6.45Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
6.45Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
6.45Consensusalpha2_onOrthosteric Ligandalpha2b_on
6.45Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
6.45Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
6.45Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
6.45Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
6.45Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
6.45Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
6.45Consensusblt_onOrthosteric Ligandblt1_on
6.45Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
6.45Consensuscck_offOrthosteric Ligandccka_off
6.45Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
6.45Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
6.45Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
6.45Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
6.45Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
6.45Consensusleukotriene_onOrthosteric Ligandblt_on
6.45Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
6.25Single4NTJAZD12834NTJ-P2Y12-AZD1283
6.25Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
6.25Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
6.25Single5WIUNemonapride5WIU-D4-Nemonapride
6.25Single5WIVNemonapride5WIV-D4-Nemonapride-Na
6.25Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
6.25Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
6.25Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
6.25Single6LUQHaloperidol6LUQ-D2-Haloperidol
6.25Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
6.25Single6TP6Filorexant6TP6-OX1-Filorexant
6.25Single6Z4SSR486926Z4S-NTS1-SR48692
6.25Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
6.25Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
6.25Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
6.25Single7WC6LSD7WC6-5-HT2A-LSD
6.25Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
6.25Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.25Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
6.25Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
6.25Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
6.25Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
6.25Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
6.25Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
6.25Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
6.25Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
6.25Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
6.25Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
6.25Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
6.25Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
6.25Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
6.25Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
6.25Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
6.25Consensusep_offOrthosteric Ligandep4_off
6.06Single4DJHJDTic4DJH-κ-JDTic
6.06Single6J20Aprepitant6J20-NK1-Aprepitant
6.06Single6TQ7SB-3348676TQ7-OX1-SB-334867
6.06Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
6.06Single7R0CAVP7R0C-V2-AVP-Arrestin2
6.06Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
6.06Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
6.06Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
6.06Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
6.06Single8XVLZibotentan8XVL-ETA-Zibotentan
6.06Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
6.06Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
6.06Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
6.06Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
6.06Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
6.06Consensustachykinin_offOrthosteric Ligandnk1_off
5.88Single5X33BIIL2605X33-BLT1-BIIL260
5.88Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
5.88Single6ZG4HTL00099366ZG4-M1-HTL0009936
5.88Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
5.88Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
5.88Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
5.88Consensusalpha1_offOrthosteric Ligandalpha1a_off
5.88Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
5.88Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
5.88Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
5.88Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
5.71Single6K1QIRL25006K1Q-ETB-IRL2500
5.71Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
5.71Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
5.71Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
5.71Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
5.56Single8IEIA1LYA8IEI-GPR156-A1LYA
5.41Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
5.41Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
5.41Single8IEPA1LYA8IEP-GPR156-A1LYA
5.41Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
5.41Single8KIGSHU91198KIG-MC3-SHU9119-Ca
5.26Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
5.26Single8IEBA1LYA8IEB-GPR156-A1LYA
5.26Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
5.26Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
5.00Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
4.88Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
4.55Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
4.55Single6D35Cholesterol6D35-SMO-Cholesterol
4.55Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
4.55Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
4.55Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
4.55Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
4.55Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
4.55Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
4.55Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
4.55Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
4.55Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
4.55Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
4.55Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.55Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.55Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.55Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.55Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
4.55Single7DTTCa7DTT-CaS-Ca-Ca
4.55Single7DTTCa7DTT-CaS-Ca-Ca
4.55Single7DTUTryptophan7DTU-CaS-Tryptophan
4.55Single7DTUTryptophan7DTU-CaS-Tryptophan
4.55Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
4.55Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
4.55Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
4.55Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
4.55Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.55Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.55Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.55Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.55Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
4.55Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
4.55Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
4.55Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
4.55Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
4.55Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
4.55Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
4.55Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
4.55Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
4.55Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
4.55Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
4.55Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
4.55Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
4.55Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
4.55Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
4.55Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.55Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.55Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.55Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.55Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.55Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.55Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
4.55Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
4.55Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.55Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.55Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
4.55Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
4.55Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.55Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.55Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.55Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.55Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.55Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.55Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.55Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.55Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
4.55Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
4.55Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
4.55Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
4.55Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
4.55Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
4.55Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
4.55Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
4.55Single7XW7K1-707XW7-TSH-K1-70
4.55Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
4.55Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
4.55Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
4.55Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
4.55Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
4.55Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
4.55Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
4.55Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
4.55Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
4.55Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
4.55Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
4.55Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
4.55Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
4.55Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
4.55Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
4.55Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
4.55Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
4.55Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
4.55Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
4.55Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
4.55Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
4.55Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
4.55Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
4.55Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
4.55Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
4.55Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.55Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.55Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
4.55Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
4.55Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
4.55Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
4.55Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
4.55Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
4.55Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
4.55Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
4.55Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
4.55Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
4.55Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
4.55Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.55Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.55Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
4.55Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
4.55Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
4.55Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
4.55Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
4.55Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
4.55Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
4.55Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
4.55Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
4.55Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
4.55Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
4.55Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
4.55Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
4.55Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
4.55Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
4.55Single8WGDWAG/WA68WGD-mGlu4; mGlu2-WAG/WA6
4.55Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.55Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.55Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55Single8WVXNorrin8WVX-LGR4-Norrin
4.55Single8WVYNorrin8WVY-LGR4-Norrin
4.55Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.55Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.55Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
4.55Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
4.55Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.55Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.55Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
4.55Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
4.55Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
4.55Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
4.55Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
4.55Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
4.55Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
4.55Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
4.55Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
4.55Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.55Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.55Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.55Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.55Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.55Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.55Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.55Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.55Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.55Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.55Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.55Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.55Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
4.55Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
4.55Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
4.55Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
4.55Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
4.55Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
4.55Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
4.55Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
4.35Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.35Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.35Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.35Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.35Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.35Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.35Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.35Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.35Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.35Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.35Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.35Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.35Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.17Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
4.17Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
4.17Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
4.17Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
4.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
4.00Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
4.00Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
4.00Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
4.00Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
4.00Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single9IVMLSN33188399IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
3.85Single5L7DCholesterol5L7D-SMO-Cholesterol
3.85Single6VCBLSN31604406VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
3.85Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
3.85Single7WC4Serotonin7WC4-5-HT2A-Serotonin
3.85Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
3.85Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
3.70Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
3.70Single3OE8IT1t3OE8-CXCR4-IT1t
3.70Single6TQ9SB-4081246TQ9-OX1-SB-408124
3.70Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
3.70Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
3.70Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
3.70Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
3.70Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
3.70Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
3.70Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
3.70Consensussensory_onOrthosteric Ligandopsins_on
3.57Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
3.57Single7F61Cholesterol7F61-H3-PF-03654746-Cholesterol
3.57Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
3.57Single7WC5Psilocin7WC5-5-HT2A-Psilocin
3.57Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
3.57Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
3.57Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
3.57Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
3.57Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
3.57Consensusgi_sensoryOrthosteric Ligandgi_opsins
3.57Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
3.57Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
3.57Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
3.57Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
3.57Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
3.57Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
3.45Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
3.45Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
3.45Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
3.45Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
3.45Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
3.45Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
3.45Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
3.45Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
3.45Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
3.45Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.45Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
3.45Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
3.45Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
3.45Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
3.45Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
3.45Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
3.45Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
3.45Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.45Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.45Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
3.33Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
3.33Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
3.33Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
3.33Single4K5YCP-3763954K5Y-CRF1-CP-376395
3.33Single4XNVBPTU4XNV-P2Y1-BPTU
3.33Single5WS3EMPA5WS3-OX2-EMPA
3.33Single6B73MP11046B73-κ-MP1104
3.33Single6C1QNDT95137276C1Q-C5a1-PMX53-NDT9513727
3.33Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
3.33Single6TODEMPA6TOD-OX1-EMPA-Na
3.33Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
3.33Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
3.33Single7XRRLemborexant7XRR-OX2-Lemborexant
3.33Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
3.33Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
3.33Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
3.33Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.33Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
3.33Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
3.33Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
3.33Consensusorexin_offOrthosteric Ligandox2_off ox1_off
3.33Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
3.33Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
3.33Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
3.23Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
3.23Single3RZECidoxepin3RZE-H1-Cidoxepin
3.23Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
3.23Single4ZJCSB-6740424ZJC-OX1-SB-674042
3.23Single6IQLL7458706IQL-D4-L745870
3.23Single6TPGEMPA6TPG-OX2-EMPA
3.23Single6TPNHTL66416TPN-OX2-HTL6641
3.23Single6ZG9GSK10347026ZG9-M1-GSK1034702
3.23Single6ZINSR486926ZIN-NTS1-SR48692
3.23Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
3.23Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
3.23Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
3.23Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
3.23Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
3.23Single8IYXYL-3658IYX-GPR34-YL-365
3.23Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
3.23Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
3.23Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
3.23Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
3.12Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
3.12Single4Z9GCP-3763954Z9G-CRF1-CP-376395
3.12Single5DHGC-355DHG-NOP-C-35
3.12Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
3.12Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
3.12Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
3.12Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
3.12Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
3.12Single8GTIBMK-C2058GTI-CRF1-BMK-C205
3.12Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
3.12Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
3.12Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
3.03Single5WQCEMPA5WQC-OX2-EMPA
3.03Single6HLPNetupitant6HLP-NK1-Netupitant
3.03Single8GTGBMK-I1528GTG-CRF1-BMK-I152
2.94Single6E59L-7607356E59-NK1-L-760735
2.94Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
2.94Single9BJKNAM9BJK-μ-Naloxone-NAM
2.86Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
2.86Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
2.86Single8GTMBMK-C2038GTM-CRF1-BMK-C203
2.78Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
2.63Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
2.63Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
2.56Single7SHEPI; PE7SHE-GPR158-PI; PE
2.50Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
2.50Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
2.44Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
2.27Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3

PDB Summary
PDB 8FLR
Class B1
SubFamily Peptide
Type Parathyroid Hormone
SubType PTH1
Species Homo Sapiens
Ligand PTHrP(1-36)
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 2.94
Date 2023-04-26
D.O.I. 10.1016/j.str.2023.04.002
Net Summary
Imin 3.11
Number of Linked Nodes 970
Number of Links 1224
Number of Hubs 219
Number of Links mediated by Hubs 788
Number of Communities 29
Number of Nodes involved in Communities 326
Number of Links involved in Communities 487
Path Summary
Number Of Nodes in MetaPath 108
Number Of Links MetaPath 107
Number of Shortest Paths 12654137
Length Of Smallest Path 3
Average Path Length 54.2758
Length of Longest Path 89
Minimum Path Strength 1.425
Average Path Strength 7.94586
Maximum Path Strength 21.99
Minimum Path Correlation 0.7
Average Path Correlation 0.998654
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.75439
Average % Of Corr. Nodes 39.0058
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 59.7713
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • enzyme regulator activity   • molecular function activator activity   • phosphorus-oxygen lyase activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • adenylate cyclase activator activity   • adenylate cyclase activity   • cation binding   • metal ion binding   • developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development
Gene OntologyBiological Process• developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • cellular response to stimulus   • cellular response to nitrogen compound   • response to stimulus   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to chemical   • cellular process   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • biological regulation   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • regulation of biological process   • regulation of cellular process   • signaling   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of multicellular organismal process   • regulation of metabolic process   • positive regulation of cellular process   • protein localization   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • localization   • cellular macromolecule localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • protein transport   • regulation of cellular localization   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • intracellular anatomical structure   • cytoplasm   • cytosol   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • trans-Golgi network   • organelle membrane   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation   • molecular transducer activity   • molecular function activator activity   • signaling receptor binding   • signaling receptor activity   • signaling receptor activator activity   • hormone activity   • molecular function regulator activity   • signaling receptor regulator activity   • receptor ligand activity   • peptide hormone receptor binding   • hormone receptor binding   • positive regulation of cell population proliferation   • regulation of cell population proliferation   • positive regulation of biological process   • positive regulation of cellular process   • ossification   • bone mineralization   • biomineral tissue development   • tissue development   • multi-multicellular organism process   • reproductive process   • female pregnancy   • multi-organism reproductive process   • negative regulation of cell population proliferation   • negative regulation of cellular process   • negative regulation of biological process   • skeletal system development   • regulation of chondrocyte differentiation   • regulation of cartilage development   • regulation of developmental process   • cellular developmental process   • connective tissue development   • negative regulation of cartilage development   • cell development   • regulation of cell differentiation   • negative regulation of chondrocyte differentiation   • negative regulation of chondrocyte development   • regulation of cell development   • regulation of chondrocyte development   • cell differentiation   • negative regulation of cell differentiation   • regulation of multicellular organismal process   • regulation of multicellular organismal development   • negative regulation of developmental process   • negative regulation of cell development   • chondrocyte differentiation   • negative regulation of multicellular organismal process   • chondrocyte development   • cartilage development   • regulation of biosynthetic process   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • regulation of gene expression   • biosynthetic process   • regulation of macromolecule biosynthetic process   • metabolic process   • macromolecule metabolic process   • regulation of metabolic process   • epidermis development   • nucleoside phosphate metabolic process   • ribose phosphate metabolic process   • cAMP metabolic process   • cyclic purine nucleotide metabolic process   • carbohydrate derivative metabolic process   • primary metabolic process   • nucleotide metabolic process   • cyclic nucleotide metabolic process   • purine-containing compound metabolic process   • nucleobase-containing compound metabolic process   • purine nucleotide metabolic process   • ribonucleotide metabolic process   • organophosphate metabolic process   • nucleobase-containing small molecule metabolic process   • phosphate-containing compound metabolic process   • small molecule metabolic process   • purine ribonucleotide metabolic process   • phosphorus metabolic process   • osteoblast development   • osteoblast differentiation   • nucleus   • membrane-enclosed lumen   • intracellular organelle lumen   • nucleoplasm   • organelle lumen   • nuclear lumen   • identical protein binding   • protein homodimerization activity   • protein dimerization activity   • amide binding   • peptide hormone binding   • hormone binding   • peptide receptor activity   • G protein-coupled receptor activity   • G protein-coupled peptide receptor activity   • transmembrane signaling receptor activity   • parathyroid hormone receptor activity   • inorganic ion homeostasis   • intracellular calcium ion homeostasis   • homeostatic process   • calcium ion homeostasis   • cellular homeostasis   • chemical homeostasis   • intracellular monoatomic cation homeostasis   • monoatomic ion homeostasis   • intracellular chemical homeostasis   • monoatomic cation homeostasis   • intracellular monoatomic ion homeostasis   • embryo development ending in birth or egg hatching   • chordate embryonic development   • embryo development   • in utero embryonic development   • anatomical structure maturation   • cell maturation   • developmental maturation   • cell surface receptor signaling pathway   • regulation of inositol phosphate biosynthetic process   • alcohol metabolic process   • positive regulation of phosphate metabolic process   • inositol phosphate metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • regulation of phosphate metabolic process   • polyol biosynthetic process   • regulation of carbohydrate metabolic process   • carbohydrate metabolic process   • polyol metabolic process   • positive regulation of phosphorus metabolic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • carbohydrate biosynthetic process   • positive regulation of inositol phosphate biosynthetic process   • organophosphate biosynthetic process   • inositol phosphate biosynthetic process   • alcohol biosynthetic process   • regulation of phosphorus metabolic process   • positive regulation of carbohydrate metabolic process   • regulation of carbohydrate biosynthetic process   • positive regulation of small molecule metabolic process   • positive regulation of alcohol biosynthetic process   • multicellular organismal-level homeostasis   • tissue remodeling   • bone remodeling   • anatomical structure homeostasis   • tissue homeostasis   • bone resorption   • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger   • intracellular membraneless organelle   • nucleolus   • membraneless organelle   • apical part of cell   • plasma membrane region   • apical plasma membrane   • basal part of cell   • basal plasma membrane   • basolateral plasma membrane   • receptor complex
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8FLR_Chain_A
EKAQREANK KIEKQLQKD KQVYRATHR LLLLGAGES GKNTIVKQM 
RILHTSGIF ETKFQVDKV NFHMFDVGA QRDERRKWI QCFNDVTAI 
IFVVASSSY NQTNRLQAA LKLFDSIWN NKWLRDTSV ILFLNKQDL 
LAEKVLAGK SKIEDYFPE FARYTTPED ATPEPGEDP RVTRAKYFI 
RDEFLRIST ASGDGRHYC YPHFTCAVD TENIRRVFN DCRDIIQRM 
HLRQYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8FLR_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8FLR_Chain_G
SIAQARKLV EQLKMEANI DRIKVSKAA ADLMAYCEA HAKEDPLLT 
PVPASENPF R


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ03431
Sequence
>8FLR_Chain_R
VMTKEEQIF LLHRAQAQC EKRLKEGRP CLPEWDHIL CWPLGAPGE 
VVAVPCPDY IYDFNHKGH AYRRCDRNG SWELVPGHN RTWANYSEC 
VKFLTNETR EREVFDRLG MIYTVGYSV SLASLTVAV LILAYFRRL 
HCTRNYIHM HLFLSFMLR AVSIFVKDA VLYSGYAGC RVAVTFFLY 
FLATNYYWI LVEGLYLHS LIFMAFFSE KKYLWGFTV FGWGLPAVF 
VAVWVSVRA TLANTGCWD LSSGNKKWI IQVPILASI VLNFILFIN 
IVRVLATKL RETTRQQYR KLLKSTLVL MPLFGVHYI VFMATPYTE 
VSGTLWQVQ MHYEMLFNS FQGFFVAII YCFCNGEVQ AEIKKSWSR 
WTL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9JR3B1PeptideParathyroid HormonePTH1Homo sapiensPTH-chim(NtGi1L-Gs-CtGq)/β1/γ22.82024-10-16To be published
9JR3 (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTH-2.82024-10-16To be published
9JR2B1PeptideParathyroid HormonePTH1Homo sapiensPTH-chim(NtGi1L-Gs-CtGq)/β1/γ22.82024-10-16To be published
9JR2 (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTH-2.82024-10-16To be published
8JR9B1PeptideParathyroid HormonePTH1Homo sapiens-PCO371chim(NtGi1-Gs)/β1/γ22.572023-08-0210.1038/s41586-023-06467-w
8JR9 (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiens-PCO3712.572023-08-0210.1038/s41586-023-06467-w
7Y36B1PeptideParathyroid HormonePTH1Homo sapiensTeriparatide-Gs/β1/γ22.82023-07-05To be published
7Y36 (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensTeriparatide-2.82023-07-05To be published
7Y35B1PeptideParathyroid HormonePTH1Homo sapiensAbaloparatide-Gs/β1/γ22.92023-07-05To be published
7Y35 (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensAbaloparatide-2.92023-07-05To be published
8GW8B1PeptideParathyroid HormonePTH1Homo sapiens-KHFGs/β1/γ22.92023-06-1410.1038/s41586-023-06169-3
8GW8 (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiens-KHF2.92023-06-1410.1038/s41586-023-06169-3
8FLUB1PeptideParathyroid HormonePTH1Homo sapiensLong-Acting PTH-Gs/β1/γ22.762023-04-2610.1016/j.str.2023.04.002
8FLU (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensLong-Acting PTH-2.762023-04-2610.1016/j.str.2023.04.002
8FLTB1PeptideParathyroid HormonePTH1Homo sapiensM-PTH(1-14)-Gs/β1/γ23.032023-04-2610.1016/j.str.2023.04.002
8FLT (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensM-PTH(1-14)-3.032023-04-2610.1016/j.str.2023.04.002
8FLSB1PeptideParathyroid HormonePTH1Homo sapiensAbaloparatide-Gs/β1/γ23.092023-04-2610.1016/j.str.2023.04.002
8FLS (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensAbaloparatide-3.092023-04-2610.1016/j.str.2023.04.002
8FLRB1PeptideParathyroid HormonePTH1Homo sapiensPTHrP(1-36)-Gs/β1/γ22.942023-04-2610.1016/j.str.2023.04.002
8FLR (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTHrP(1-36)-2.942023-04-2610.1016/j.str.2023.04.002
8FLQB1PeptideParathyroid HormonePTH1Homo sapiensPTH-Gs/β1/γ22.552023-04-2610.1016/j.str.2023.04.002
8FLQ (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTH-2.552023-04-2610.1016/j.str.2023.04.002
8HAOB1PeptideParathyroid HormonePTH1Homo sapiensPTH-chim(NtGi1-Gs)/β1/γ23.762022-12-2110.1038/s41401-022-01032-z
8HAO (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTH-3.762022-12-2110.1038/s41401-022-01032-z
8HAFB1PeptideParathyroid HormonePTH1Homo sapiensPTHrP(1-36)-chim(NtGi1-Gs)/β1/γ23.252022-12-2110.1038/s41401-022-01032-z
8HAF (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTHrP(1-36)-3.252022-12-2110.1038/s41401-022-01032-z
8HA0B1PeptideParathyroid HormonePTH1Homo sapiensPTH-chim(NtGi1-Gs)/β1/γ22.622022-12-2110.1038/s41401-022-01032-z
8HA0 (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTH-2.622022-12-2110.1038/s41401-022-01032-z
7VVOB1PeptideParathyroid HormonePTH1Homo sapiensPTH-Gs/β1/γ24.12022-08-0310.1016/j.molcel.2022.07.003
7VVO (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTH-4.12022-08-0310.1016/j.molcel.2022.07.003
7VVNB1PeptideParathyroid HormonePTH1Homo sapiensPTH-Gs/β1/γ23.82022-08-0310.1016/j.molcel.2022.07.003
7VVN (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTH-3.82022-08-0310.1016/j.molcel.2022.07.003
7VVMB1PeptideParathyroid HormonePTH1Homo sapiensPTH-Gs/β1/γ23.22022-08-0310.1016/j.molcel.2022.07.003
7VVM (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTH-3.22022-08-0310.1016/j.molcel.2022.07.003
7VVLB1PeptideParathyroid HormonePTH1Homo sapiensPTH-Gs/β1/γ22.82022-08-0310.1016/j.molcel.2022.07.003
7VVL (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTH-2.82022-08-0310.1016/j.molcel.2022.07.003
7VVKB1PeptideParathyroid HormonePTH1Homo sapiensPTH-Gs/β1/γ23.32022-08-0310.1016/j.molcel.2022.07.003
7VVK (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTH-3.32022-08-0310.1016/j.molcel.2022.07.003
7VVJB1PeptideParathyroid HormonePTH1Homo sapiensPTHrP(1-36)-Gs/β1/γ23.22022-08-0310.1016/j.molcel.2022.07.003
7VVJ (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensPTHrP(1-36)-3.22022-08-0310.1016/j.molcel.2022.07.003
6NBIB1PeptideParathyroid HormonePTH1Homo sapiensLong-Acting PTH Analog-Gs/β1/γ242019-04-1710.1126/science.aav7942
6NBI (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensLong-Acting PTH Analog-42019-04-1710.1126/science.aav7942
6NBHB1PeptideParathyroid HormonePTH1Homo sapiensLong-Acting PTH Analog-Gs/β1/γ23.52019-04-1710.1126/science.aav7942
6NBH (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensLong-Acting PTH Analog-3.52019-04-1710.1126/science.aav7942
6NBFB1PeptideParathyroid HormonePTH1Homo sapiensLong-Acting PTH Analog-Gs/β1/γ232019-04-1710.1126/science.aav7942
6NBF (No Gprot) B1PeptideParathyroid HormonePTH1Homo sapiensLong-Acting PTH Analog-32019-04-1710.1126/science.aav7942
6FJ3B1PeptideParathyroid HormonePTH1Homo sapiensPTH--2.52018-11-2110.1038/s41594-018-0151-4




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8FLR.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.