psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D185	R:R:R186	7.15	No	No	0	2	5
2	R:R:M189	R:R:R186	9.93	No	No	0	4	5
3	R:R:H442	R:R:L187	3.86	No	No	0	5	5
4	R:R:Y191	R:R:Y195	14.89	No	Yes	0	7	7
5	R:R:M445	R:R:Y191	8.38	No	No	0	6	7
6	R:R:F450	R:R:G194	4.52	Yes	No	0	7	9
7	R:R:I237	R:R:Y195	14.51	No	Yes	0	7	7
8	R:R:S449	R:R:Y195	3.82	No	Yes	0	9	7
9	R:R:F453	R:R:V197	9.18	Yes	No	0	6	5
10	R:R:G452	R:R:S198	3.71	No	No	0	9	9
11	R:R:F453	R:R:S201	3.96	Yes	No	0	6	8
12	R:R:F230	R:R:L202	4.87	Yes	No	0	8	9
13	R:R:L202	R:R:M231	5.65	No	Yes	0	9	8
14	R:R:G452	R:R:L202	5.13	No	No	0	9	9
15	R:R:M231	R:R:T203	4.52	Yes	No	0	8	3
16	R:R:A205	R:R:C460	3.61	No	No	0	9	9
17	R:R:L209	R:R:N220	4.12	No	No	0	7	9
18	R:R:L209	R:R:M224	4.24	No	No	0	7	5
19	R:R:F227	R:R:L209	4.87	No	No	0	9	7
20	R:R:F212	R:R:Y211	11.35	Yes	No	0	7	2
21	R:R:F212	R:R:S473	6.61	Yes	No	0	7	4
22	R:R:E469	R:R:R214	8.14	No	No	0	9	7
23	R:R:L215	R:R:N220	4.12	No	No	0	9	9
24	R:R:E469	R:R:L215	6.63	No	No	0	9	9
25	R:R:H216	R:R:Y221	10.89	No	No	0	8	7
26	R:R:T218	R:R:Y305	9.99	Yes	Yes	0	7	8
27	R:R:E317	R:R:T218	7.06	No	Yes	0	6	7
28	R:R:L321	R:R:T218	7.37	No	Yes	0	6	7
29	R:R:N220	R:R:R219	4.82	No	No	0	9	9
30	R:R:H223	R:R:R219	9.03	No	No	0	9	9
31	R:R:E465	R:R:R219	10.47	No	No	0	9	9
32	R:R:E302	R:R:I222	13.66	No	No	0	9	9
33	R:R:I222	R:R:Y305	7.25	No	Yes	0	9	8
34	R:R:E302	R:R:H223	13.54	No	No	1	9	9
35	R:R:H223	W:W:?1	24.52	No	Yes	1	9	0
36	R:R:H225	R:R:W298	17.98	No	Yes	3	8	9
37	R:R:H225	R:R:T325	9.58	No	No	3	8	5
38	R:R:H225	R:R:W329	6.35	No	Yes	3	8	9
39	R:R:F230	R:R:L226	4.87	Yes	No	0	8	9
40	R:R:S229	R:R:T294	4.8	No	Yes	0	9	8
41	R:R:N295	R:R:S229	7.45	No	No	0	8	9
42	R:R:F230	R:R:N295	22.96	Yes	No	0	8	8
43	R:R:F230	R:R:Q451	9.37	Yes	Yes	0	8	9
44	R:R:F230	R:R:V455	5.24	Yes	No	0	8	9
45	R:R:F291	R:R:L232	18.27	Yes	No	0	5	8
46	R:R:L292	R:R:R233	4.86	Yes	Yes	0	6	8
47	R:R:N295	R:R:R233	7.23	No	Yes	0	8	8
48	R:R:N448	R:R:R233	4.82	No	Yes	0	6	8
49	R:R:Q451	R:R:R233	9.35	Yes	Yes	0	9	8
50	R:R:F291	R:R:S236	7.93	Yes	No	0	5	7
51	R:R:F288	R:R:I237	5.02	Yes	No	0	7	7
52	R:R:F288	R:R:K240	12.41	Yes	No	0	7	7
53	R:R:G277	R:R:R282	4.5	No	No	0	4	8
54	R:R:C281	R:R:C351	7.28	No	No	0	9	9
55	R:R:N348	R:R:R282	9.64	No	No	0	7	8
56	R:R:R282	R:R:W352	26.99	No	Yes	0	8	8
57	R:R:D353	R:R:V285	4.38	No	No	0	5	6
58	R:R:T286	R:R:V340	4.76	No	No	0	7	5
59	R:R:F287	R:R:F291	4.29	No	Yes	0	3	5
60	R:R:F288	R:R:L289	3.65	Yes	No	0	7	7
61	R:R:F288	R:R:L292	3.65	Yes	Yes	0	7	6
62	R:R:L289	R:R:W339	6.83	No	Yes	0	7	8
63	R:R:F291	R:R:Y290	8.25	Yes	Yes	0	5	9
64	R:R:T294	R:R:Y290	8.74	Yes	Yes	3	8	9
65	R:R:W329	R:R:Y290	7.72	Yes	Yes	3	9	9
66	R:R:A333	R:R:Y290	5.34	No	Yes	0	5	9
67	R:R:V336	R:R:Y290	5.05	No	Yes	0	7	9
68	R:R:L292	R:R:Y296	3.52	Yes	Yes	2	6	7
69	R:R:L292	R:R:Y421	5.86	Yes	Yes	2	6	8
70	R:R:A293	R:R:P332	3.74	No	No	0	6	9
71	R:R:T294	R:R:W329	6.06	Yes	Yes	3	8	9
72	R:R:P332	R:R:T294	3.5	No	Yes	0	9	8
73	R:R:I367	R:R:Y296	6.04	No	Yes	2	7	7
74	R:R:I371	R:R:Y296	4.84	Yes	Yes	2	7	7
75	R:R:Y296	R:R:Y421	9.93	Yes	Yes	2	7	8
76	R:R:F327	R:R:Y297	5.16	No	Yes	4	5	6
77	R:R:L331	R:R:Y297	10.55	No	Yes	4	4	6
78	R:R:P332	R:R:Y297	15.3	No	Yes	0	9	6
79	R:R:F335	R:R:Y297	4.13	No	Yes	4	5	6
80	R:R:P366	R:R:Y297	5.56	No	Yes	4	9	6
81	R:R:V301	R:R:W298	6.13	No	Yes	0	8	9
82	R:R:T325	R:R:W298	3.64	No	Yes	3	5	9
83	R:R:W298	R:R:W329	24.37	Yes	Yes	3	9	9
84	R:R:I299	R:R:N374	4.25	No	No	0	9	9
85	R:R:I299	W:W:?1	12.1	No	Yes	0	9	0
86	R:R:L300	R:R:L304	5.54	No	No	0	8	5
87	R:R:L300	R:R:S370	7.51	No	No	0	8	7
88	R:R:L300	R:R:L373	8.3	No	No	0	8	7
89	R:R:F324	R:R:V301	3.93	No	No	0	7	8
90	R:R:E302	W:W:?1	15.44	No	Yes	1	9	0
91	R:R:L304	R:R:L377	4.15	No	No	0	5	7
92	R:R:L309	R:R:Y305	15.24	No	Yes	0	8	8
93	R:R:F315	R:R:Y305	4.13	No	Yes	0	6	8
94	R:R:F324	R:R:Y305	6.19	No	Yes	0	7	8
95	R:R:I381	R:R:L306	4.28	Yes	No	0	9	9
96	R:R:F311	R:R:H307	21.5	No	No	6	6	8
97	R:R:H307	R:R:L377	6.43	No	No	0	8	7
98	R:R:H307	R:R:N380	8.93	No	No	6	8	8
99	R:R:F315	R:R:S308	5.28	No	No	0	6	7
100	R:R:F311	R:R:I310	3.77	No	No	0	6	8
101	R:R:F311	R:R:N380	4.83	No	No	6	6	8
102	R:R:F315	R:R:Y320	19.6	No	No	0	6	4
103	R:R:E317	R:R:K318	5.4	No	No	0	6	5
104	R:R:F327	R:R:G328	4.52	No	No	0	5	9
105	R:R:F327	R:R:L331	6.09	No	No	4	5	4
106	R:R:F335	R:R:L331	8.53	No	No	4	5	4
107	R:R:F335	R:R:P366	14.45	No	No	4	5	9
108	R:R:V340	R:R:W339	3.68	No	Yes	5	5	8
109	R:R:R343	R:R:W339	5	No	Yes	5	8	8
110	R:R:W339	R:R:W352	7.5	Yes	Yes	5	8	8
111	R:R:I362	R:R:W339	8.22	No	Yes	0	8	8
112	R:R:I363	R:R:W339	5.87	No	Yes	0	7	8
113	R:R:V340	R:R:W352	3.68	No	Yes	5	5	8
114	R:R:I362	R:R:V342	4.61	No	No	0	8	5
115	R:R:R343	R:R:W352	21.99	No	Yes	5	8	8
116	R:R:R343	R:R:S356	9.22	No	No	0	8	4
117	R:R:K359	R:R:L346	8.46	No	No	0	3	3
118	R:R:C351	R:R:D353	6.22	No	No	0	9	5
119	R:R:K360	R:R:S355	12.24	No	No	0	7	7
120	R:R:K359	R:R:S356	4.59	No	No	0	3	4
121	R:R:N358	R:R:W361	4.52	No	No	0	4	8
122	R:R:K360	R:R:W361	6.96	No	No	0	7	8
123	R:R:Q364	R:R:Y421	10.15	No	Yes	2	7	8
124	R:R:M425	R:R:Q364	4.08	No	No	2	6	7
125	R:R:P366	R:R:V365	3.53	No	No	0	9	5
126	R:R:I367	R:R:Y421	8.46	No	Yes	2	7	8
127	R:R:G418	R:R:I371	7.05	No	Yes	0	9	7
128	R:R:I371	R:R:Y421	3.63	Yes	Yes	2	7	8
129	R:R:F375	R:R:I379	5.02	No	No	0	7	5
130	R:R:F378	R:R:V382	3.93	Yes	No	0	9	7
131	R:R:F378	R:R:T410	3.89	Yes	No	0	9	9
132	R:R:F378	R:R:P415	14.45	Yes	No	0	9	9
133	R:R:N380	R:R:R383	7.23	No	No	0	8	8
134	R:R:I381	R:R:L385	4.28	Yes	No	0	9	8
135	R:R:I381	R:R:L413	4.28	Yes	No	0	9	9
136	R:R:R383	R:R:V384	3.92	No	No	0	8	8
137	R:R:E391	R:R:T387	4.23	No	No	0	7	7
138	R:R:L389	R:R:Q402	9.32	No	No	0	8	6
139	R:R:L389	R:R:L406	4.15	No	No	0	8	8
140	R:R:Q402	R:R:T399	4.25	No	No	0	6	6
141	R:R:R400	R:R:R404	7.46	No	No	0	8	6
142	R:R:L407	R:R:R404	3.64	No	No	0	8	6
143	R:R:K408	R:R:R404	7.43	No	No	0	8	6
144	R:R:L407	R:R:L411	4.15	No	No	0	8	8
145	R:R:K408	R:R:V412	4.55	No	No	0	8	8
146	R:R:L413	W:W:?1	4.4	No	Yes	0	9	0
147	R:R:L416	R:R:M414	4.24	Yes	No	0	9	8
148	R:R:P415	W:W:?1	6.09	No	Yes	0	9	0
149	R:R:H420	R:R:L416	7.71	Yes	Yes	0	8	9
150	R:R:L416	W:W:?1	5.13	Yes	Yes	0	9	0
151	R:R:F417	R:R:F447	7.5	No	Yes	1	9	5
152	R:R:F417	R:R:Q451	22.25	No	Yes	1	9	9
153	R:R:F417	W:W:?1	25.16	No	Yes	1	9	0
154	R:R:F424	R:R:H420	4.53	Yes	Yes	1	7	8
155	R:R:H420	R:R:Y443	7.62	Yes	No	1	8	4
156	R:R:F447	R:R:H420	15.84	Yes	Yes	1	5	8
157	R:R:M425	R:R:Y421	3.59	No	Yes	2	6	8
158	R:R:F424	R:R:V423	3.93	Yes	No	0	7	6
159	R:R:F424	R:R:Y443	4.13	Yes	No	1	7	4
160	R:R:E444	R:R:F424	24.49	No	Yes	0	7	7
161	R:R:F424	R:R:F447	6.43	Yes	Yes	1	7	5
162	R:R:P428	R:R:T427	3.5	No	No	0	7	5
163	R:R:Q440	R:R:T427	15.59	No	No	0	6	5
164	R:R:M441	R:R:W437	13.96	No	No	0	6	5
165	R:R:H442	R:R:Q438	13.6	No	No	0	5	4
166	R:R:M441	R:R:Q440	6.8	No	No	0	6	6
167	R:R:E444	R:R:M445	4.06	No	No	0	7	6
168	R:R:F447	R:R:N448	4.83	Yes	No	0	5	6
169	R:R:F447	R:R:Q451	8.2	Yes	Yes	1	5	9
170	R:R:F450	R:R:S449	6.61	Yes	No	0	7	9
171	R:R:F450	R:R:F454	5.36	Yes	No	0	7	6
172	R:R:F453	R:R:I457	12.56	Yes	No	0	6	6
173	R:R:V455	R:R:Y459	5.05	No	No	0	9	8
174	R:R:F461	R:R:I457	3.77	No	No	0	8	6
175	R:R:I458	W:W:?1	4.54	No	Yes	0	8	0
176	R:R:Y459	W:W:?1	55.26	No	Yes	0	8	0
177	R:R:E465	R:R:N463	3.94	No	Yes	0	9	9
178	R:R:N463	R:R:V466	5.91	Yes	No	0	9	9
179	R:R:N463	W:W:?1	22.55	Yes	Yes	0	9	0
180	R:R:E469	R:R:K472	8.1	No	No	0	9	7
181	R:R:T478	R:R:W474	6.06	No	No	0	4	5
182	R:R:L481	R:R:W477	6.83	No	No	0	4	4
183	R:R:A456	R:R:S201	3.42	No	No	0	8	8
184	R:R:H216	R:R:R213	3.39	No	No	0	8	8
185	R:R:Q364	R:R:W361	3.29	No	No	0	7	8
186	R:R:F375	R:R:F378	3.22	No	Yes	0	7	9
187	R:R:F450	R:R:F453	3.22	Yes	Yes	0	7	6
188	R:R:V412	W:W:?1	3.16	No	Yes	0	8	0
189	R:R:A344	R:R:N348	3.13	No	No	0	4	7
190	R:R:I376	R:R:V372	3.07	No	No	0	4	4
191	R:R:I381	R:R:V384	3.07	Yes	No	0	9	8
192	R:R:I470	R:R:V466	3.07	No	No	0	5	9
193	R:R:K319	R:R:S316	3.06	No	No	0	6	7
194	R:R:M231	R:R:V206	3.04	Yes	No	0	8	5
195	R:R:M189	R:R:T192	3.01	No	No	0	4	7
196	R:R:L199	R:R:V235	2.98	No	No	0	7	4
197	R:R:L228	R:R:V206	2.98	No	No	0	4	5
198	R:R:L289	R:R:V285	2.98	No	No	0	7	6
199	R:R:L436	R:R:V439	2.98	No	No	0	4	5
200	R:R:L199	R:R:M231	2.83	No	Yes	0	7	8
201	R:R:L368	R:R:M425	2.83	No	No	0	4	6
202	R:R:C460	R:R:F227	2.79	No	No	0	9	9
203	R:R:E391	R:R:K388	2.7	No	No	0	7	9
204	R:R:A234	R:R:Y195	2.67	No	Yes	0	8	7
205	R:R:F461	R:R:V204	2.62	No	No	0	8	5
206	R:R:R390	R:R:T387	2.59	No	No	0	6	7
207	R:R:S316	R:R:Y320	2.54	No	No	0	7	4
208	R:R:F212	R:R:I208	2.51	Yes	No	0	7	8
209	R:R:F212	R:R:L215	2.44	Yes	No	0	7	9
210	R:R:K360	R:R:Y429	2.39	No	No	0	7	6
211	R:R:L321	R:R:Y221	2.34	No	No	0	6	7
212	R:R:Q401	R:R:R400	2.34	No	No	0	6	8
213	R:R:G277	R:R:G350	2.11	No	No	0	4	5
214	R:R:A333	R:R:G330	1.95	No	No	0	5	7
215	R:R:W474	R:R:W477	1.87	No	No	0	5	4
216	R:R:G194	R:R:V193	1.84	No	No	0	9	6
217	R:R:G280	R:R:V283	1.84	No	No	0	4	4
218	R:R:G350	R:R:T349	1.82	No	No	0	5	5
219	R:R:G303	R:R:L377	1.71	No	No	0	9	7
220	R:R:A284	R:R:V239	1.7	No	No	0	6	5
221	R:R:A242	R:R:V243	1.7	No	No	0	4	5
222	R:R:G357	R:R:N358	1.7	No	No	0	6	4
223	R:R:G464	R:R:N463	1.7	No	Yes	0	7	9
224	R:R:C217	R:R:T218	1.69	No	Yes	0	8	7
225	R:R:A347	R:R:T349	1.68	No	No	0	7	5
226	R:R:S196	R:R:V193	1.62	No	No	0	7	6
227	R:R:A210	R:R:M224	1.61	No	No	0	4	5
228	R:R:A284	R:R:K240	1.61	No	No	0	6	7
229	R:R:S341	R:R:T345	1.6	No	No	0	5	3
230	R:R:S475	R:R:T478	1.6	No	No	0	4	4
231	R:R:A386	R:R:L406	1.58	No	No	0	6	8
232	R:R:I190	R:R:V193	1.54	No	No	0	6	6
233	R:R:I362	R:R:V338	1.54	No	No	0	8	5
234	R:R:K405	R:R:S409	1.53	No	No	0	8	9
235	R:R:L385	R:R:S409	1.5	No	No	0	8	9
236	R:R:L446	R:R:S449	1.5	No	No	0	5	9
237	R:R:L416	R:R:V419	1.49	Yes	No	0	9	7
238	R:R:I371	R:R:I422	1.47	Yes	No	0	7	5
239	R:R:L389	R:R:T392	1.47	No	No	0	8	7
240	R:R:G323	R:R:W322	1.41	No	No	0	1	3
241	R:R:A242	R:R:F238	1.39	No	No	0	4	7
242	R:R:L385	R:R:L406	1.38	No	No	0	8	8
243	R:R:D241	R:R:L244	1.36	No	No	0	8	5
244	R:R:E444	R:R:M441	1.35	No	No	0	7	6
245	R:R:R476	R:R:S475	1.32	No	No	0	7	4
246	R:R:F287	R:R:V283	1.31	No	No	0	3	4
247	R:R:K472	R:R:R476	1.24	No	No	0	7	7
248	R:R:K318	R:R:W322	1.16	No	No	0	5	3
249	R:R:Q438	R:R:W437	1.1	No	No	0	4	5
250	R:R:R400	R:R:Y403	1.03	No	No	0	8	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y195	8.9725	4	0	7
2	R:R:F212	5.7275	4	0	7
3	R:R:T218	6.5275	4	0	7
4	R:R:F230	9.462	5	0	8
5	R:R:M231	4.01	4	0	8
6	R:R:R233	6.565	4	0	8
7	R:R:F288	6.1825	4	0	7
8	R:R:Y290	7.02	5	3	9
9	R:R:F291	9.685	4	0	5
10	R:R:L292	4.4725	4	2	6
11	R:R:T294	5.775	4	3	8
12	R:R:Y296	6.0825	4	2	7
13	R:R:Y297	8.14	5	4	6
14	R:R:W298	13.03	4	3	9
15	R:R:Y305	8.56	5	0	8
16	R:R:W329	11.125	4	3	9
17	R:R:W339	6.18333	6	5	8
18	R:R:W352	15.04	4	5	8
19	R:R:I371	4.2475	4	2	7
20	R:R:F378	6.3725	4	0	9
21	R:R:I381	3.9775	4	0	9
22	R:R:L416	4.6425	4	0	9
23	R:R:H420	8.925	4	1	8
24	R:R:Y421	6.93667	6	2	8
25	R:R:F424	8.702	5	1	7
26	R:R:F447	8.56	5	1	5
27	R:R:F450	4.9275	4	0	7
28	R:R:Q451	12.2925	4	1	9
29	R:R:F453	7.23	4	0	6
30	R:R:N463	8.525	4	0	9
31	W:W:?1	16.2136	11	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:M441	R:R:W437	11.0148	13.96	No	No	0	6	5
2	R:R:E444	R:R:M441	22.0148	1.35	No	No	0	7	6
3	R:R:E444	R:R:M445	30.7076	4.06	No	No	0	7	6
4	R:R:M445	R:R:Y191	29.0029	8.38	No	No	0	6	7
5	R:R:Y191	R:R:Y195	28.1064	14.89	No	Yes	0	7	7
6	R:R:F450	R:R:S449	38.6803	6.61	Yes	No	0	7	9
7	R:R:S449	R:R:Y195	44.4118	3.82	No	Yes	0	9	7
8	R:R:F450	R:R:G194	12.1611	4.52	Yes	No	0	7	9
9	R:R:I237	R:R:Y195	27.7316	14.51	No	Yes	0	7	7
10	R:R:F450	R:R:F453	21.1331	3.22	Yes	Yes	0	7	6
11	R:R:F230	R:R:L202	24.9908	4.87	Yes	No	0	8	9
12	R:R:F230	R:R:Q451	32.383	9.37	Yes	Yes	0	8	9
13	R:R:F447	R:R:Q451	13.9026	8.2	Yes	Yes	1	5	9
14	R:R:F424	R:R:F447	34.4037	6.43	Yes	Yes	1	7	5
15	R:R:E444	R:R:F424	49.0337	24.49	No	Yes	0	7	7
16	R:R:L202	R:R:M231	16.7904	5.65	No	Yes	0	9	8
17	R:R:L209	R:R:N220	14.3214	4.12	No	No	0	7	9
18	R:R:N220	R:R:R219	47.4392	4.82	No	No	0	9	9
19	R:R:H223	R:R:R219	48.9456	9.03	No	No	0	9	9
20	R:R:H223	W:W:?1	44.9482	24.52	No	Yes	1	9	0
21	R:R:L416	W:W:?1	26.5045	5.13	Yes	Yes	0	9	0
22	R:R:H420	R:R:L416	26.0195	7.71	Yes	Yes	0	8	9
23	R:R:F424	R:R:H420	20.8685	4.53	Yes	Yes	1	7	8
24	R:R:F417	W:W:?1	100	25.16	No	Yes	1	9	0
25	R:R:F417	R:R:F447	21.4417	7.5	No	Yes	1	9	5
26	R:R:L215	R:R:N220	32.214	4.12	No	No	0	9	9
27	R:R:E469	R:R:L215	21.0816	6.63	No	No	0	9	9
28	R:R:T218	R:R:Y305	19.8839	9.99	Yes	Yes	0	7	8
29	R:R:I222	R:R:Y305	36.2407	7.25	No	Yes	0	9	8
30	R:R:E302	R:R:I222	37.6809	13.66	No	No	0	9	9
31	R:R:E302	W:W:?1	33.2354	15.44	No	Yes	1	9	0
32	R:R:N463	W:W:?1	10.5298	22.55	Yes	Yes	0	9	0
33	R:R:S229	R:R:T294	60.9964	4.8	No	Yes	0	9	8
34	R:R:N295	R:R:S229	63.3772	7.45	No	No	0	8	9
35	R:R:F230	R:R:N295	37.9161	22.96	Yes	No	0	8	8
36	R:R:N295	R:R:R233	41.1786	7.23	No	Yes	0	8	8
37	R:R:Q451	R:R:R233	73.8482	9.35	Yes	Yes	0	9	8
38	R:R:F230	R:R:V455	22.5292	5.24	Yes	No	0	8	9
39	R:R:F291	R:R:Y290	18.451	8.25	Yes	Yes	0	5	9
40	R:R:T294	R:R:Y290	27.1291	8.74	Yes	Yes	3	8	9
41	R:R:L292	R:R:R233	82.4014	4.86	Yes	Yes	0	6	8
42	R:R:F288	R:R:I237	29.0249	5.02	Yes	No	0	7	7
43	R:R:R282	R:R:W352	12.3889	26.99	No	Yes	0	8	8
44	R:R:W339	R:R:W352	13.5572	7.5	Yes	Yes	5	8	8
45	R:R:L289	R:R:W339	31.4057	6.83	No	Yes	0	7	8
46	R:R:F288	R:R:L289	38.9742	3.65	Yes	No	0	7	7
47	R:R:L292	R:R:Y421	24.1017	5.86	Yes	Yes	2	6	8
48	R:R:P332	R:R:T294	26.7103	3.5	No	Yes	0	9	8
49	R:R:P332	R:R:Y297	20.8759	15.3	No	Yes	0	9	6
50	R:R:F324	R:R:Y305	10.2506	6.19	No	Yes	0	7	8
51	R:R:L413	W:W:?1	52.017	4.4	No	Yes	0	9	0
52	R:R:I381	R:R:L413	49.9449	4.28	Yes	No	0	9	9
53	R:R:I381	R:R:V384	27.1511	3.07	Yes	No	0	9	8
54	R:R:R383	R:R:V384	24.9394	3.92	No	No	0	8	8
55	R:R:N380	R:R:R383	22.7129	7.23	No	No	0	8	8
56	R:R:H307	R:R:N380	16.0115	8.93	No	No	6	8	8
57	R:R:H307	R:R:L377	14.0054	6.43	No	No	0	8	7
58	R:R:F315	R:R:Y305	10.133	4.13	No	Yes	0	6	8
59	R:R:Q364	R:R:Y421	12.2272	10.15	No	Yes	2	7	8
60	R:R:Q364	R:R:W361	10.7208	3.29	No	No	0	7	8
61	R:R:F378	R:R:P415	11.5659	14.45	Yes	No	0	9	9
62	R:R:P415	W:W:?1	13.8658	6.09	No	Yes	0	9	0
63	R:R:I381	R:R:L385	20.4717	4.28	Yes	No	0	9	8
64	R:R:L385	R:R:L406	13.8144	1.38	No	No	0	8	8
65	R:R:V412	W:W:?1	18.4069	3.16	No	Yes	0	8	0
66	R:R:K408	R:R:V412	16.298	4.55	No	No	0	8	8
67	R:R:K408	R:R:R404	14.0128	7.43	No	No	0	8	6
68	R:R:Y459	W:W:?1	22.2206	55.26	No	Yes	0	8	0
69	R:R:E469	R:R:K472	16.6581	8.1	No	No	0	9	7
70	R:R:K472	R:R:R476	14.3214	1.24	No	No	0	7	7
71	R:R:R476	R:R:S475	11.97	1.32	No	No	0	7	4
72	R:R:F288	R:R:L292	61.8561	3.65	Yes	Yes	0	7	6
73	R:R:F417	R:R:Q451	79.1094	22.25	No	Yes	1	9	9
74	R:R:V455	R:R:Y459	21.8164	5.05	No	No	0	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:H223	R:R:R219	9.03	1	No	No	9	9	1	2
R:R:E465	R:R:R219	10.47	0	No	No	9	9	2	2
R:R:E302	R:R:I222	13.66	1	No	No	9	9	1	2
R:R:E302	R:R:H223	13.54	1	No	No	9	9	1	1
R:R:H223	W:W:?1	24.52	1	No	Yes	9	0	1	0
R:R:I299	R:R:N374	4.25	0	No	No	9	9	1	2
R:R:I299	W:W:?1	12.1	0	No	Yes	9	0	1	0
R:R:E302	W:W:?1	15.44	1	No	Yes	9	0	1	0
R:R:F378	R:R:P415	14.45	0	Yes	No	9	9	2	1
R:R:I381	R:R:L413	4.28	0	Yes	No	9	9	2	1
R:R:K408	R:R:V412	4.55	0	No	No	8	8	2	1
R:R:L413	W:W:?1	4.4	0	No	Yes	9	0	1	0
R:R:L416	R:R:M414	4.24	0	Yes	No	9	8	1	2
R:R:P415	W:W:?1	6.09	0	No	Yes	9	0	1	0
R:R:H420	R:R:L416	7.71	1	Yes	Yes	8	9	2	1
R:R:L416	W:W:?1	5.13	0	Yes	Yes	9	0	1	0
R:R:F417	R:R:F447	7.5	1	No	Yes	9	5	1	2
R:R:F417	R:R:Q451	22.25	1	No	Yes	9	9	1	2
R:R:F417	W:W:?1	25.16	1	No	Yes	9	0	1	0
R:R:F447	R:R:H420	15.84	1	Yes	Yes	5	8	2	2
R:R:F447	R:R:Q451	8.2	1	Yes	Yes	5	9	2	2
R:R:V455	R:R:Y459	5.05	0	No	No	9	8	2	1
R:R:I458	W:W:?1	4.54	0	No	Yes	8	0	1	0
R:R:Y459	W:W:?1	55.26	0	No	Yes	8	0	1	0
R:R:E465	R:R:N463	3.94	0	No	Yes	9	9	2	1
R:R:N463	R:R:V466	5.91	0	Yes	No	9	9	1	2
R:R:N463	W:W:?1	22.55	0	Yes	Yes	9	0	1	0
R:R:V412	W:W:?1	3.16	0	No	Yes	8	0	1	0
R:R:G464	R:R:N463	1.7	0	No	Yes	7	9	2	1
R:R:L416	R:R:V419	1.49	0	Yes	No	9	7	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8JR9_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.5
Number of Linked Nodes	234
Number of Links	250
Number of Hubs	31
Number of Links mediated by Hubs	117
Number of Communities	6
Number of Nodes involved in Communities	34
Number of Links involved in Communities	45

Path Summary
Number Of Nodes in MetaPath	75
Number Of Links MetaPath	74
Number of Shortest Paths	35495
Length Of Smallest Path	3
Average Path Length	11.8823
Length of Longest Path	26
Minimum Path Strength	1.28
Average Path Strength	8.78936
Maximum Path Strength	40.21
Minimum Path Correlation	0.7
Average Path Correlation	0.925426
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.55556
Average % Of Corr. Nodes	51.3587
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.1286
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • D2 dopamine receptor binding • adenylate cyclase inhibitor activity • molecular function inhibitor activity • cyclase inhibitor activity • enzyme inhibitor activity • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • negative regulation of peptide hormone secretion • negative regulation of establishment of protein localization • negative regulation of protein secretion • negative regulation of signaling • negative regulation of cell communication • negative regulation of peptide secretion • negative regulation of cellular process • negative regulation of protein localization • negative regulation of insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • identical protein binding • protein homodimerization activity • protein dimerization activity • amide binding • peptide hormone binding • hormone binding • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • parathyroid hormone receptor activity • ossification • bone mineralization • biomineral tissue development • tissue development • skeletal system development • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • osteoblast development • cellular developmental process • cell differentiation • cell development • osteoblast differentiation • embryo development ending in birth or egg hatching • chordate embryonic development • embryo development • in utero embryonic development • anatomical structure maturation • cell maturation • developmental maturation • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • cell surface receptor signaling pathway • negative regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • connective tissue development • chondrocyte differentiation • cartilage development • regulation of inositol phosphate biosynthetic process • alcohol metabolic process • positive regulation of phosphate metabolic process • inositol phosphate metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • phosphate-containing compound metabolic process • polyol biosynthetic process • small molecule metabolic process • phosphorus metabolic process • regulation of carbohydrate metabolic process • regulation of biosynthetic process • carbohydrate metabolic process • polyol metabolic process • positive regulation of phosphorus metabolic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • carbohydrate biosynthetic process • primary metabolic process • positive regulation of inositol phosphate biosynthetic process • biosynthetic process • organophosphate metabolic process • organophosphate biosynthetic process • inositol phosphate biosynthetic process • alcohol biosynthetic process • metabolic process • regulation of phosphorus metabolic process • positive regulation of carbohydrate metabolic process • regulation of carbohydrate biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • multicellular organismal-level homeostasis • tissue remodeling • bone remodeling • anatomical structure homeostasis • tissue homeostasis • bone resorption • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • apical part of cell • plasma membrane region • apical plasma membrane • basal part of cell • basal plasma membrane • basolateral plasma membrane • receptor complex
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	KHF
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	KHF
Name	PCO-371
Synonyms	1-[3,5-dimethyl-4-[2-[[4-oxidanylidene-2-[4-(trifluoromethyloxy)phenyl]-1,3,8-triazaspiro[4.5]dec-1-en-8-yl]sulfonyl]ethyl]phenyl]-5,5-dimethyl-imidazolidine-2,4-dione
Identifier
Formula	C29 H32 F3 N5 O6 S
Molecular Weight	635.654
SMILES
PubChem	76283707
Formal Charge	0
Total Atoms	76
Total Chiral Atoms	0
Total Bonds	80
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q03431
Sequence	>8JR9_nogp_Chain_R D R L A M I Y T V G Y S V S L A S L T V A V L I L A Y F R R L H C T R N Y I H M H L F L S F M L R A V S I F V K D A V L A G Y A G C R V A V T F F L Y F L A T N Y Y W I L V E G L Y L H S L I F M A F F S E K K Y L W G F T V F G W G L P A V F V A V W V S V R A T L A N T G C W D L S S G N K K W I I Q V P I L A S I V L N F I L F I N I V R V L A T K L R E T N T R Q Q Y R K L L K S T L V L M P L F G V H Y I V F M A T P Y L W Q V Q M H Y E M L F N S F Q G F F V A I I Y C F C N G E V Q A E I K K S W S R W T L A L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8GW8	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371	Gs/β1/γ2	2.9	2023-06-14	doi.org/10.1038/s41586-023-06169-3
	8GW8 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371		2.9	2023-06-14	doi.org/10.1038/s41586-023-06169-3
	8JR9	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371	chim(NtGi1-Gs)/β1/γ2	2.57	2023-08-02	doi.org/10.1038/s41586-023-06467-w
	8JR9 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371		2.57	2023-08-02	doi.org/10.1038/s41586-023-06467-w
	7VVJ	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/β1/γ2	3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVJ (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVK	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.3	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVK (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.3	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVL	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVL (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVM	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVM (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVN	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVN (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	4.1	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		4.1	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	8FLQ	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.55	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLQ (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.55	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLR	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/β1/γ2	2.94	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLR (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		2.94	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLS	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/β1/γ2	3.09	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLS (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-		3.09	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLT	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	M-PTH(1-14)	-	Gs/β1/γ2	3.03	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLT (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	M-PTH(1-14)	-		3.03	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLU	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-	Gs/β1/γ2	2.76	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLU (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-		2.76	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8HA0	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/β1/γ2	2.62	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HA0 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.62	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAF	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	chim(NtGi1-Gs)/β1/γ2	3.25	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAF (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		3.25	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/β1/γ2	3.76	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.76	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	6FJ3	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	-	2.5	2018-11-21	doi.org/10.1038/s41594-018-0151-4
	6NBF	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	3	2019-04-17	doi.org/10.1126/science.aav7942
	6NBF (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		3	2019-04-17	doi.org/10.1126/science.aav7942
	6NBH	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	3.5	2019-04-17	doi.org/10.1126/science.aav7942
	6NBH (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		3.5	2019-04-17	doi.org/10.1126/science.aav7942
	6NBI	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	4	2019-04-17	doi.org/10.1126/science.aav7942
	6NBI (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		4	2019-04-17	doi.org/10.1126/science.aav7942
	9B5Y	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-	chim(NtGi1-Gq)/β1/γ2	3.49	2025-03-19	doi.org/10.1073/pnas.2426178122
	9B5Y (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-		3.49	2025-03-19	doi.org/10.1073/pnas.2426178122
	7Y35	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/β1/γ2	2.9	2023-07-05	To be published
	7Y35 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-		2.9	2023-07-05	To be published
	7Y36	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Teriparatide	-	Gs/β1/γ2	2.8	2023-07-05	To be published
	7Y36 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Teriparatide	-		2.8	2023-07-05	To be published
	9JR2	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-10-16	To be published
	9JR2 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2024-10-16	To be published
	9JR3	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-10-16	To be published
	9JR3 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2024-10-16	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8JR9_nogp.zip

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