psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:Q6	L:L:S1	4.33	Yes	No	0	0	0
2	L:L:I5	L:L:V2	10.75	Yes	No	1	0	0
3	L:L:V2	R:R:Q364	7.16	No	Yes	1	0	7
4	L:L:V2	R:R:I367	4.61	No	No	1	0	7
5	L:L:E4	L:L:S3	2.87	Yes	No	1	0	0
6	L:L:S3	R:R:E444	11.5	No	Yes	1	0	7
7	L:L:S3	R:R:M445	3.07	No	Yes	1	0	6
8	L:L:E4	R:R:Y195	6.73	Yes	Yes	1	0	7
9	L:L:E4	R:R:R233	4.65	Yes	Yes	1	0	8
10	L:L:E4	R:R:M445	8.12	Yes	Yes	1	0	6
11	L:L:I5	R:R:L289	4.28	Yes	Yes	1	0	7
12	L:L:I5	R:R:L292	2.85	Yes	No	1	0	6
13	L:L:I5	R:R:Q364	4.12	Yes	Yes	1	0	7
14	L:L:N10	L:L:Q6	6.6	No	Yes	1	0	0
15	L:L:Q6	R:R:Y429	12.4	Yes	Yes	1	0	6
16	L:L:Q6	R:R:W437	3.29	Yes	Yes	1	0	5
17	L:L:Q6	R:R:M441	6.8	Yes	Yes	1	0	6
18	L:L:L7	R:R:F184	3.65	No	No	0	0	6
19	L:L:L7	R:R:M441	5.65	No	Yes	0	0	6
20	L:L:L7	R:R:M445	5.65	No	Yes	0	0	6
21	L:L:M8	R:R:K240	2.88	Yes	Yes	1	0	7
22	L:L:M8	R:R:L244	2.83	Yes	Yes	1	0	5
23	L:L:M8	R:R:F288	3.73	Yes	Yes	1	0	7
24	L:L:M8	R:R:D353	4.16	Yes	No	0	0	5
25	L:L:H9	R:R:S355	8.37	No	No	0	0	7
26	L:L:H9	R:R:K360	3.93	No	No	1	0	7
27	L:L:H9	R:R:Y429	4.36	No	Yes	1	0	6
28	L:L:N10	R:R:V432	4.43	No	No	1	0	5
29	L:L:N10	R:R:W437	7.91	No	Yes	1	0	5
30	L:L:L11	L:L:L15	4.15	No	No	0	0	0
31	L:L:L11	R:R:F184	8.53	No	No	0	0	6
32	L:L:L11	R:R:Y245	14.07	No	No	0	0	4
33	L:L:K13	L:L:N16	4.2	No	No	0	0	0
34	L:L:K13	R:R:V31	9.11	No	Yes	0	0	6
35	L:L:H14	L:L:L15	3.86	Yes	No	8	0	0
36	L:L:H14	L:L:M18	13.13	Yes	No	0	0	0
37	L:L:H14	R:R:E180	8.62	Yes	No	0	0	3
38	L:L:H14	R:R:R181	6.77	Yes	No	8	0	3
39	L:L:L15	R:R:R181	3.64	No	No	8	0	3
40	L:L:N16	R:R:T33	7.31	No	No	6	0	7
41	L:L:N16	R:R:E35	5.26	No	No	6	0	5
42	L:L:R20	L:L:S17	3.95	Yes	No	7	0	0
43	L:L:S17	R:R:V31	4.85	No	Yes	7	0	6
44	L:L:M18	R:R:E177	5.41	No	No	0	0	1
45	L:L:E19	R:R:K34	4.05	No	Yes	0	0	4
46	L:L:R20	R:R:V31	5.23	Yes	Yes	7	0	6
47	L:L:R20	R:R:Y136	10.29	Yes	No	7	0	4
48	L:L:R20	R:R:D137	13.1	Yes	No	0	0	5
49	L:L:R25	L:L:V21	3.92	Yes	No	0	0	0
50	L:L:L24	L:L:W23	4.56	Yes	Yes	0	0	0
51	L:L:K27	L:L:W23	10.44	No	Yes	0	0	0
52	L:L:W23	R:R:K34	3.48	Yes	Yes	6	0	4
53	L:L:W23	R:R:Q37	4.38	Yes	Yes	0	0	7
54	L:L:W23	R:R:I38	5.87	Yes	No	6	0	7
55	L:L:L24	L:L:R25	3.64	Yes	Yes	0	0	0
56	L:L:L24	R:R:D137	14.93	Yes	No	0	0	5
57	L:L:L24	R:R:F138	12.18	Yes	Yes	0	0	4
58	L:L:R25	R:R:V171	3.92	Yes	Yes	0	0	3
59	L:L:L28	R:R:F138	7.31	No	Yes	2	0	4
60	L:L:L28	R:R:V171	2.98	No	Yes	2	0	3
61	L:L:D30	L:L:F34	9.55	No	No	9	0	0
62	L:L:D30	R:R:H114	6.3	No	No	9	0	4
63	L:L:V31	R:R:D113	4.38	No	No	0	0	9
64	L:L:V31	R:R:H114	4.15	No	No	0	0	4
65	L:L:H32	L:L:N33	7.65	No	No	0	0	0
66	L:L:F34	L:L:N33	15.71	No	No	0	0	0
67	L:L:F34	R:R:H114	5.66	No	No	9	0	4
68	R:R:V31	R:R:Y136	5.05	Yes	No	7	6	4
69	R:R:E36	R:R:M32	10.83	No	No	0	6	6
70	R:R:M32	R:R:Q37	4.08	No	Yes	0	6	7
71	R:R:M32	R:R:Y136	5.99	No	No	0	6	4
72	R:R:E35	R:R:T33	12.7	No	No	6	5	7
73	R:R:E36	R:R:T33	15.52	No	No	0	6	7
74	R:R:E35	R:R:K34	4.05	No	Yes	6	5	4
75	R:R:I38	R:R:K34	4.36	No	Yes	6	7	4
76	R:R:L40	R:R:Q37	9.32	No	Yes	0	5	7
77	R:R:I135	R:R:Q37	8.23	Yes	Yes	0	7	7
78	R:R:L40	R:R:Y134	3.52	No	Yes	0	5	5
79	R:R:L41	R:R:Y134	3.52	No	Yes	0	8	5
80	R:R:H42	R:R:Q45	19.78	No	No	0	4	7
81	R:R:A44	R:R:R43	2.77	No	No	0	7	4
82	R:R:Q47	R:R:R43	8.18	No	No	0	6	4
83	R:R:A44	R:R:Y134	5.34	No	Yes	0	7	5
84	R:R:E49	R:R:Q45	8.92	No	No	0	6	7
85	R:R:A46	R:R:E49	3.02	No	No	0	5	6
86	R:R:C117	R:R:C48	7.28	No	No	0	9	8
87	R:R:G105	R:R:R106	3	No	No	0	5	1
88	R:R:G105	R:R:P123	4.06	No	No	0	5	7
89	R:R:P107	R:R:R106	2.88	No	No	0	3	1
90	R:R:N151	R:R:R106	10.85	No	No	0	5	1
91	R:R:C108	R:R:G121	3.92	Yes	No	0	9	7
92	R:R:C108	R:R:C148	5.46	Yes	Yes	3	9	9
93	R:R:C108	R:R:G152	3.92	Yes	No	3	9	9
94	R:R:C108	R:R:W154	6.53	Yes	Yes	3	9	9
95	R:R:L109	R:R:P110	4.93	No	No	0	5	6
96	R:R:D113	R:R:E111	15.59	No	No	0	9	7
97	R:R:E111	R:R:R146	5.82	No	Yes	0	7	8
98	R:R:E111	R:R:T163	7.06	No	No	0	7	5
99	R:R:C117	R:R:W112	7.84	No	No	0	9	7
100	R:R:D113	R:R:W118	5.58	No	No	0	9	9
101	R:R:I115	R:R:L116	2.85	Yes	Yes	2	5	5
102	R:R:I115	R:R:P132	5.08	Yes	Yes	2	5	9
103	R:R:I115	R:R:Y134	7.25	Yes	Yes	2	5	5
104	R:R:I115	R:R:I135	2.94	Yes	Yes	2	5	7
105	R:R:I115	R:R:Y167	7.25	Yes	Yes	2	5	5
106	R:R:L116	R:R:W118	9.11	Yes	No	0	5	9
107	R:R:L116	R:R:P132	6.57	Yes	Yes	2	5	9
108	R:R:L116	R:R:Y134	5.86	Yes	Yes	2	5	5
109	R:R:V129	R:R:W118	4.9	No	No	0	5	9
110	R:R:E125	R:R:L120	3.98	Yes	No	3	5	4
111	R:R:L120	R:R:V127	2.98	No	Yes	3	4	7
112	R:R:E125	R:R:G121	3.27	Yes	No	0	5	7
113	R:R:A122	R:R:E125	7.54	No	Yes	0	1	5
114	R:R:G124	R:R:R147	3	No	Yes	0	7	3
115	R:R:E125	R:R:V127	4.28	Yes	Yes	3	5	7
116	R:R:V126	R:R:Y145	3.79	No	Yes	5	4	4
117	R:R:R147	R:R:V126	3.92	Yes	No	5	3	4
118	R:R:V127	R:R:V129	3.21	Yes	No	0	7	5
119	R:R:R146	R:R:V127	10.46	Yes	Yes	3	8	7
120	R:R:A128	R:R:H143	5.85	No	No	0	5	3
121	R:R:P130	R:R:V129	3.53	No	No	0	5	5
122	R:R:C131	R:R:P132	3.77	No	Yes	2	9	9
123	R:R:C131	R:R:C170	7.28	No	No	2	9	9
124	R:R:P132	R:R:Y134	4.17	Yes	Yes	2	9	5
125	R:R:I135	R:R:P132	5.08	Yes	Yes	2	7	9
126	R:R:F138	R:R:P132	8.67	Yes	Yes	2	4	9
127	R:R:P132	R:R:Y167	2.78	Yes	Yes	2	9	5
128	R:R:D133	R:R:H140	12.61	No	No	0	2	3
129	R:R:I135	R:R:Y134	6.04	Yes	Yes	2	7	5
130	R:R:D137	R:R:I135	2.8	No	Yes	0	5	7
131	R:R:F138	R:R:I135	3.77	Yes	Yes	2	4	7
132	R:R:F138	R:R:Y167	6.19	Yes	Yes	2	4	5
133	R:R:C170	R:R:F138	4.19	No	Yes	2	9	4
134	R:R:F138	R:R:V171	3.93	Yes	Yes	2	4	3
135	R:R:K141	R:R:N139	6.99	No	No	0	3	4
136	R:R:E169	R:R:K141	4.05	Yes	No	0	5	3
137	R:R:G142	R:R:H143	4.77	No	No	0	5	3
138	R:R:E169	R:R:G142	4.91	Yes	No	0	5	5
139	R:R:R147	R:R:Y145	5.14	Yes	Yes	5	3	4
140	R:R:W164	R:R:Y145	4.82	Yes	Yes	5	5	4
141	R:R:N166	R:R:Y145	6.98	No	Yes	5	7	4
142	R:R:C148	R:R:R146	2.79	Yes	Yes	3	9	8
143	R:R:R146	R:R:W154	7	Yes	Yes	3	8	9
144	R:R:E155	R:R:R147	5.82	Yes	Yes	5	4	3
145	R:R:C148	R:R:G152	3.92	Yes	No	3	9	9
146	R:R:C148	R:R:W154	3.92	Yes	Yes	3	9	9
147	R:R:D149	R:R:R150	13.1	No	No	0	5	1
148	R:R:D149	R:R:E155	15.59	No	Yes	0	5	4
149	R:R:R150	R:R:S153	5.27	No	No	0	1	4
150	R:R:N151	R:R:S153	4.47	No	No	0	5	4
151	R:R:T163	R:R:W154	3.64	No	Yes	0	5	9
152	R:R:E155	R:R:V157	4.28	Yes	No	5	4	4
153	R:R:E155	R:R:W164	8.72	Yes	Yes	5	4	5
154	R:R:P158	R:R:V157	5.3	No	No	0	4	4
155	R:R:V157	R:R:W164	4.9	No	Yes	5	4	5
156	R:R:N161	R:R:P158	8.15	No	No	0	7	4
157	R:R:H160	R:R:R162	3.39	No	No	0	4	3
158	R:R:N166	R:R:W164	3.39	No	Yes	5	7	5
159	R:R:S168	R:R:V171	3.23	No	Yes	0	6	3
160	R:R:E180	R:R:V432	5.7	No	No	0	3	5
161	R:R:D185	R:R:R181	9.53	No	No	0	2	3
162	R:R:R186	R:R:V183	5.23	No	No	0	5	4
163	R:R:L187	R:R:V183	2.98	Yes	No	0	5	4
164	R:R:F184	R:R:W437	4.01	No	Yes	0	6	5
165	R:R:H442	R:R:R186	4.51	No	No	0	5	5
166	R:R:L187	R:R:M441	4.24	Yes	Yes	0	5	6
167	R:R:H442	R:R:L187	3.86	No	Yes	0	5	5
168	R:R:L187	R:R:M445	4.24	Yes	Yes	0	5	6
169	R:R:I190	R:R:M445	2.92	No	Yes	0	6	6
170	R:R:T192	R:R:Y191	3.75	No	Yes	0	7	7
171	R:R:Y191	R:R:Y195	4.96	Yes	Yes	0	7	7
172	R:R:D241	R:R:Y191	8.05	No	Yes	0	8	7
173	R:R:M445	R:R:Y191	7.18	Yes	Yes	0	6	7
174	R:R:R233	R:R:Y195	11.32	Yes	Yes	1	8	7
175	R:R:A234	R:R:Y195	5.34	No	Yes	1	8	7
176	R:R:I237	R:R:Y195	7.25	No	Yes	0	7	7
177	R:R:F238	R:R:Y195	3.09	No	Yes	1	7	7
178	R:R:S449	R:R:Y195	5.09	No	Yes	0	9	7
179	R:R:F453	R:R:V197	9.18	No	No	0	6	5
180	R:R:G452	R:R:S198	3.71	No	No	0	9	9
181	R:R:L199	R:R:M231	4.24	No	Yes	0	7	8
182	R:R:L199	R:R:V235	2.98	No	No	0	7	4
183	R:R:F453	R:R:S201	5.28	No	No	0	6	8
184	R:R:A456	R:R:S201	3.42	No	No	0	8	8
185	R:R:F227	R:R:L202	4.87	No	No	0	9	9
186	R:R:L202	R:R:M231	5.65	No	Yes	0	9	8
187	R:R:A456	R:R:L202	3.15	No	No	0	8	9
188	R:R:L207	R:R:T203	2.95	No	No	0	3	3
189	R:R:M231	R:R:T203	3.01	Yes	No	0	8	3
190	R:R:A205	R:R:F227	2.77	No	No	0	9	9
191	R:R:A205	R:R:C460	3.61	No	No	0	9	9
192	R:R:F227	R:R:V206	3.93	No	No	0	9	5
193	R:R:M231	R:R:V206	3.04	Yes	No	0	8	5
194	R:R:L209	R:R:M224	4.24	No	No	0	7	5
195	R:R:C460	R:R:L209	4.76	No	No	0	9	7
196	R:R:F212	R:R:L215	4.87	Yes	No	0	7	9
197	R:R:E469	R:R:F212	10.49	No	Yes	0	9	7
198	R:R:F212	R:R:I470	3.77	Yes	No	0	7	5
199	R:R:F212	R:R:S473	3.96	Yes	No	0	7	4
200	R:R:H216	R:R:R213	7.9	No	No	0	8	8
201	R:R:E469	R:R:R214	10.47	No	No	0	9	7
202	R:R:K472	R:R:R214	4.95	No	No	0	7	7
203	R:R:L215	R:R:N220	5.49	No	No	0	9	9
204	R:R:L215	R:R:V466	4.47	No	Yes	0	9	9
205	R:R:H216	R:R:Y221	5.44	No	No	0	8	7
206	R:R:C217	R:R:T218	3.38	No	Yes	0	8	7
207	R:R:T218	R:R:Y305	7.49	Yes	Yes	0	7	8
208	R:R:K318	R:R:T218	4.5	No	Yes	0	5	7
209	R:R:N220	R:R:R219	6.03	No	No	0	9	9
210	R:R:H223	R:R:R219	11.28	No	No	0	9	9
211	R:R:E465	R:R:R219	5.82	No	No	0	9	9
212	R:R:E302	R:R:I222	6.83	Yes	No	0	9	9
213	R:R:I222	R:R:Y305	8.46	No	Yes	0	9	8
214	R:R:E302	R:R:H223	8.62	Yes	No	0	9	9
215	R:R:H223	R:R:Y459	5.44	No	Yes	0	9	8
216	R:R:H225	R:R:W298	20.1	No	Yes	1	8	9
217	R:R:H225	R:R:W329	3.17	No	Yes	1	8	9
218	R:R:L226	R:R:S229	4.5	Yes	No	0	9	9
219	R:R:F230	R:R:L226	7.31	Yes	Yes	1	8	9
220	R:R:I299	R:R:L226	2.85	Yes	Yes	1	9	9
221	R:R:E302	R:R:L226	9.28	Yes	Yes	0	9	9
222	R:R:L228	R:R:L232	5.54	No	No	0	4	8
223	R:R:N295	R:R:S229	7.45	Yes	No	0	8	9
224	R:R:S229	R:R:W298	8.65	No	Yes	0	9	9
225	R:R:F230	R:R:N295	18.12	Yes	Yes	1	8	8
226	R:R:F230	R:R:I299	6.28	Yes	Yes	1	8	9
227	R:R:F230	R:R:Q451	8.2	Yes	Yes	1	8	9
228	R:R:F230	R:R:G452	3.01	Yes	No	0	8	9
229	R:R:F291	R:R:L232	12.18	No	No	0	5	8
230	R:R:L292	R:R:R233	7.29	No	Yes	1	6	8
231	R:R:N295	R:R:R233	13.26	Yes	Yes	1	8	8
232	R:R:R233	R:R:Y296	3.09	Yes	Yes	1	8	7
233	R:R:R233	R:R:Y421	3.09	Yes	Yes	1	8	8
234	R:R:A234	R:R:F238	2.77	No	No	1	8	7
235	R:R:F288	R:R:S236	3.96	Yes	No	0	7	7
236	R:R:F291	R:R:S236	9.25	No	No	0	5	7
237	R:R:F288	R:R:I237	3.77	Yes	No	0	7	7
238	R:R:D241	R:R:K240	4.15	No	Yes	0	8	7
239	R:R:K240	R:R:L244	4.23	Yes	Yes	1	7	5
240	R:R:F288	R:R:K240	16.13	Yes	Yes	1	7	7
241	R:R:A284	R:R:V243	5.09	No	No	0	6	5
242	R:R:L244	R:R:Y245	9.38	Yes	No	0	5	4
243	R:R:L244	R:R:V285	2.98	Yes	No	0	5	6
244	R:R:G277	R:R:R282	4.5	No	No	0	4	8
245	R:R:C281	R:R:C351	7.28	No	No	0	9	9
246	R:R:N348	R:R:R282	9.64	No	No	0	7	8
247	R:R:R282	R:R:W352	26.99	No	Yes	0	8	8
248	R:R:F287	R:R:V283	7.87	No	No	0	3	4
249	R:R:L289	R:R:V285	2.98	Yes	No	0	7	6
250	R:R:T286	R:R:V340	3.17	No	No	1	7	5
251	R:R:T286	R:R:W352	4.85	No	Yes	1	7	8
252	R:R:F288	R:R:L289	6.09	Yes	Yes	1	7	7
253	R:R:L289	R:R:W339	4.56	Yes	Yes	1	7	8
254	R:R:I363	R:R:L289	4.28	No	Yes	1	7	7
255	R:R:F291	R:R:Y290	7.22	No	Yes	0	5	9
256	R:R:T294	R:R:Y290	8.74	No	Yes	1	8	9
257	R:R:W329	R:R:Y290	3.86	Yes	Yes	1	9	9
258	R:R:P332	R:R:Y290	2.78	Yes	Yes	1	9	9
259	R:R:L292	R:R:Y296	5.86	No	Yes	1	6	7
260	R:R:A293	R:R:F335	2.77	No	Yes	0	6	5
261	R:R:T294	R:R:W329	6.06	No	Yes	1	8	9
262	R:R:P332	R:R:T294	3.5	Yes	No	1	9	8
263	R:R:I299	R:R:N295	7.08	Yes	Yes	1	9	8
264	R:R:I367	R:R:Y296	8.46	No	Yes	1	7	7
265	R:R:I371	R:R:Y296	4.84	Yes	Yes	1	7	7
266	R:R:Y296	R:R:Y421	14.89	Yes	Yes	1	7	8
267	R:R:F327	R:R:Y297	7.22	No	Yes	0	5	6
268	R:R:L331	R:R:Y297	7.03	No	Yes	0	4	6
269	R:R:P332	R:R:Y297	9.74	Yes	Yes	1	9	6
270	R:R:F335	R:R:Y297	9.28	Yes	Yes	1	5	6
271	R:R:V301	R:R:W298	3.68	No	Yes	0	8	9
272	R:R:T325	R:R:W298	4.85	No	Yes	0	5	9
273	R:R:W298	R:R:W329	20.62	Yes	Yes	1	9	9
274	R:R:I299	R:R:Q451	6.86	Yes	Yes	1	9	9
275	R:R:L300	R:R:L304	6.92	Yes	No	0	8	5
276	R:R:L300	R:R:S370	10.51	Yes	No	0	8	7
277	R:R:L300	R:R:L373	5.54	Yes	No	0	8	7
278	R:R:L300	R:R:N374	4.12	Yes	No	0	8	9
279	R:R:F324	R:R:V301	3.93	No	No	0	7	8
280	R:R:E302	R:R:L416	7.95	Yes	No	0	9	9
281	R:R:F417	R:R:G303	6.02	Yes	No	0	9	9
282	R:R:L304	R:R:L377	2.77	No	No	0	5	7
283	R:R:L309	R:R:Y305	16.41	No	Yes	0	8	8
284	R:R:F324	R:R:Y305	5.16	No	Yes	0	7	8
285	R:R:I310	R:R:L306	2.85	Yes	Yes	4	8	9
286	R:R:I381	R:R:L306	7.14	No	Yes	4	9	9
287	R:R:L306	R:R:L413	2.77	Yes	Yes	4	9	9
288	R:R:F417	R:R:L306	4.87	Yes	Yes	4	9	9
289	R:R:H307	R:R:M312	5.25	No	No	0	8	5
290	R:R:H307	R:R:L377	9	No	No	0	8	7
291	R:R:H307	R:R:N380	12.75	No	No	0	8	8
292	R:R:A313	R:R:S308	3.42	No	No	0	7	7
293	R:R:F311	R:R:I310	5.02	Yes	Yes	4	6	8
294	R:R:I310	R:R:I381	4.42	Yes	No	4	8	9
295	R:R:I310	R:R:V384	4.61	Yes	No	4	8	8
296	R:R:F311	R:R:M312	3.73	Yes	No	0	6	5
297	R:R:F311	R:R:N380	7.25	Yes	No	0	6	8
298	R:R:F311	R:R:V384	5.24	Yes	No	4	6	8
299	R:R:A313	R:R:S316	3.42	No	No	0	7	7
300	R:R:F314	R:R:F315	30.01	No	No	0	7	6
301	R:R:S316	R:R:Y320	6.36	No	No	0	7	4
302	R:R:E317	R:R:K318	6.75	No	No	0	6	5
303	R:R:E317	R:R:K319	14.85	No	No	0	6	6
304	R:R:E317	R:R:Y320	3.37	No	No	0	6	4
305	R:R:G323	R:R:W322	2.81	No	No	0	1	3
306	R:R:V326	R:R:W322	9.81	No	No	0	4	3
307	R:R:L331	R:R:V334	2.98	No	No	0	4	4
308	R:R:F335	R:R:P332	2.89	Yes	Yes	1	5	9
309	R:R:F335	R:R:I363	7.54	Yes	No	1	5	7
310	R:R:F335	R:R:P366	8.67	Yes	No	0	5	9
311	R:R:V340	R:R:W339	3.68	No	Yes	1	5	8
312	R:R:W339	R:R:W352	6.56	Yes	Yes	1	8	8
313	R:R:I362	R:R:W339	7.05	No	Yes	0	8	8
314	R:R:I363	R:R:W339	10.57	No	Yes	1	7	8
315	R:R:V340	R:R:W352	9.81	No	Yes	1	5	8
316	R:R:L346	R:R:V342	2.98	No	Yes	0	3	5
317	R:R:K359	R:R:V342	4.55	Yes	Yes	0	3	5
318	R:R:I362	R:R:V342	4.61	No	Yes	0	8	5
319	R:R:R343	R:R:T349	3.88	Yes	No	0	8	5
320	R:R:R343	R:R:W352	8	Yes	Yes	1	8	8
321	R:R:R343	R:R:S356	9.22	Yes	No	1	8	4
322	R:R:K359	R:R:R343	3.71	Yes	Yes	1	3	8
323	R:R:L346	R:R:T345	4.42	No	No	0	3	3
324	R:R:A347	R:R:S356	3.42	No	No	0	7	4
325	R:R:C351	R:R:D353	4.67	No	No	0	9	5
326	R:R:D353	R:R:L354	6.79	No	No	0	5	5
327	R:R:K359	R:R:S356	7.65	Yes	No	1	3	4
328	R:R:K360	R:R:W361	8.12	No	Yes	1	7	8
329	R:R:K360	R:R:Y429	17.91	No	Yes	1	7	6
330	R:R:Q364	R:R:W361	10.95	Yes	Yes	1	7	8
331	R:R:W361	R:R:Y429	3.86	Yes	Yes	1	8	6
332	R:R:Q364	R:R:Y429	10.15	Yes	Yes	1	7	6
333	R:R:P366	R:R:V365	3.53	No	No	0	9	5
334	R:R:I367	R:R:I371	2.94	No	Yes	1	7	7
335	R:R:L368	R:R:M425	4.24	No	Yes	0	4	6
336	R:R:I371	R:R:Y421	4.84	Yes	Yes	1	7	8
337	R:R:M425	R:R:V372	4.56	Yes	No	0	6	4
338	R:R:F417	R:R:N374	12.08	Yes	No	0	9	9
339	R:R:F375	R:R:I379	8.79	No	No	0	7	5
340	R:R:F375	R:R:I422	23.86	No	No	0	7	5
341	R:R:F378	R:R:V382	7.87	Yes	No	0	9	7
342	R:R:F378	R:R:L413	7.31	Yes	Yes	4	9	9
343	R:R:F378	R:R:F417	12.86	Yes	Yes	4	9	9
344	R:R:F378	R:R:V419	9.18	Yes	No	0	9	7
345	R:R:N380	R:R:R383	6.03	No	No	0	8	8
346	R:R:I381	R:R:L413	2.85	No	Yes	4	9	9
347	R:R:T410	R:R:V382	4.76	No	No	0	9	7
348	R:R:K388	R:R:V384	4.55	No	No	0	9	8
349	R:R:A386	R:R:L406	3.15	No	No	0	6	8
350	R:R:L389	R:R:Q402	6.65	No	No	0	8	6
351	R:R:K405	R:R:L389	2.82	No	No	0	8	8
352	R:R:L389	R:R:L406	2.77	No	No	0	8	8
353	R:R:Q402	R:R:T399	2.83	No	No	0	6	6
354	R:R:Q401	R:R:R404	10.51	No	No	0	6	6
355	R:R:K405	R:R:K408	4.31	No	No	0	8	8
356	R:R:K405	R:R:S409	4.59	No	No	0	8	9
357	R:R:L406	R:R:T410	2.95	No	No	0	8	9
358	R:R:L407	R:R:L411	5.54	No	No	0	8	8
359	R:R:K408	R:R:V412	3.04	No	No	0	8	8
360	R:R:F417	R:R:L413	8.53	Yes	Yes	4	9	9
361	R:R:M414	R:R:P415	3.35	No	No	0	8	9
362	R:R:M414	R:R:V419	4.56	No	No	0	8	7
363	R:R:I458	R:R:P415	5.08	No	No	0	8	9
364	R:R:F417	R:R:L416	6.09	Yes	No	0	9	9
365	R:R:L416	R:R:Y459	12.89	No	Yes	0	9	8
366	R:R:G418	R:R:H420	3.18	No	Yes	1	9	8
367	R:R:G418	R:R:Y421	2.9	No	Yes	1	9	8
368	R:R:H420	R:R:Y421	23.96	Yes	Yes	1	8	8
369	R:R:H420	R:R:Y443	3.27	Yes	Yes	1	8	4
370	R:R:F447	R:R:H420	6.79	No	Yes	1	5	8
371	R:R:H420	R:R:N448	8.93	Yes	No	1	8	6
372	R:R:H420	R:R:Q451	11.13	Yes	Yes	1	8	9
373	R:R:N448	R:R:Y421	16.28	No	Yes	1	6	8
374	R:R:Q451	R:R:Y421	9.02	Yes	Yes	1	9	8
375	R:R:F424	R:R:V423	9.18	Yes	No	1	7	6
376	R:R:V423	R:R:Y443	7.57	No	Yes	1	6	4
377	R:R:F424	R:R:T427	7.78	Yes	No	1	7	5
378	R:R:F424	R:R:Q440	17.57	Yes	No	1	7	6
379	R:R:F424	R:R:Y443	7.22	Yes	Yes	1	7	4
380	R:R:E444	R:R:F424	3.5	Yes	Yes	1	7	7
381	R:R:A426	R:R:M425	3.22	No	Yes	0	5	6
382	R:R:P428	R:R:T427	3.5	No	No	0	7	5
383	R:R:Q440	R:R:T427	12.76	No	No	1	6	5
384	R:R:L436	R:R:T430	2.95	No	No	0	4	5
385	R:R:T430	R:R:W437	3.64	No	Yes	0	5	5
386	R:R:V432	R:R:W437	9.81	No	Yes	1	5	5
387	R:R:Q438	R:R:W437	3.29	No	Yes	0	4	5
388	R:R:M441	R:R:W437	15.12	Yes	Yes	1	6	5
389	R:R:E444	R:R:Y443	3.37	Yes	Yes	1	7	4
390	R:R:F447	R:R:Y443	16.5	No	Yes	1	5	4
391	R:R:E444	R:R:N448	13.15	Yes	No	1	7	6
392	R:R:F450	R:R:L446	3.65	No	No	0	7	5
393	R:R:F450	R:R:F454	7.5	No	No	0	7	6
394	R:R:F453	R:R:I457	11.3	No	No	0	6	6
395	R:R:F461	R:R:I457	3.77	No	No	0	8	6
396	R:R:I458	R:R:Y459	8.46	No	Yes	0	8	8
397	R:R:C460	R:R:V466	3.42	No	Yes	0	9	9
398	R:R:E465	R:R:N463	5.26	No	No	0	9	9
399	R:R:N463	R:R:V466	5.91	No	Yes	0	9	9
400	R:R:I470	R:R:V466	3.07	No	Yes	0	5	9
401	R:R:T478	R:R:W474	12.13	No	No	0	4	5
402	R:R:L481	R:R:W477	3.42	No	No	0	4	4
403	L:L:E22	L:L:K26	2.7	No	No	0	0	0
404	R:R:A144	R:R:Y167	2.67	No	Yes	0	7	5
405	R:R:A333	R:R:Y290	2.67	No	Yes	0	5	9
406	R:R:R476	R:R:S475	2.64	No	No	0	7	4
407	R:R:F461	R:R:V204	2.62	No	No	0	8	5
408	R:R:F335	R:R:V336	2.62	Yes	No	0	5	7
409	R:R:F375	R:R:V419	2.62	No	No	0	7	7
410	R:R:R179	R:R:T178	2.59	No	No	0	3	3
411	R:R:F287	R:R:T286	2.59	No	No	0	3	7
412	R:R:V455	R:R:Y459	2.52	No	Yes	0	9	8
413	R:R:F212	R:R:I208	2.51	Yes	No	0	7	8
414	R:R:F447	R:R:L446	2.44	No	No	0	5	5
415	R:R:M224	R:R:Y221	2.39	No	No	0	5	7
416	L:L:E22	L:L:R25	2.33	No	Yes	0	0	0
417	R:R:E36	R:R:F39	2.33	No	No	0	6	7
418	R:R:N358	R:R:W361	2.26	No	Yes	0	4	8
419	R:R:G277	R:R:G350	2.11	No	No	0	4	5
420	R:R:G330	R:R:P332	2.03	No	Yes	0	7	9
421	R:R:P110	R:R:P119	1.95	No	No	0	6	6
422	R:R:A279	R:R:G280	1.95	No	No	0	4	4
423	R:R:A122	R:R:P123	1.87	No	No	0	1	7
424	R:R:G194	R:R:S449	1.86	No	No	0	9	9
425	R:R:G194	R:R:V193	1.84	No	No	0	9	6
426	R:R:G280	R:R:V283	1.84	No	No	0	4	4
427	R:R:G328	R:R:V301	1.84	No	No	0	9	8
428	R:R:G357	R:R:K359	1.74	No	Yes	0	6	3
429	L:L:G12	R:R:L354	1.71	No	No	0	0	5
430	R:R:A284	R:R:V239	1.7	No	No	0	6	5
431	R:R:G464	R:R:N463	1.7	No	No	0	7	9
432	R:R:L120	R:R:P119	1.64	No	No	0	4	6
433	R:R:L156	R:R:P158	1.64	No	No	0	4	4
434	R:R:C462	R:R:I457	1.64	No	No	0	6	6
435	R:R:G464	R:R:Q467	1.64	No	No	0	7	8
436	R:R:S196	R:R:V193	1.62	No	No	0	7	6
437	R:R:S196	R:R:V197	1.62	No	No	0	7	5
438	R:R:S341	R:R:V342	1.62	No	Yes	0	5	5
439	R:R:V235	R:R:V239	1.6	No	No	0	4	5
440	R:R:S475	R:R:T478	1.6	No	No	0	4	4
441	R:R:G159	R:R:H160	1.59	No	No	0	3	4
442	R:R:A344	R:R:N348	1.56	No	No	0	4	7
443	R:R:I362	R:R:V338	1.54	No	No	0	8	5
444	L:L:M18	L:L:S17	1.53	No	No	0	0	0
445	R:R:C117	R:R:Q47	1.53	No	No	0	9	6
446	R:R:K172	R:R:S168	1.53	No	No	0	3	6
447	R:R:C131	R:R:E169	1.52	No	Yes	2	9	5
448	R:R:C170	R:R:E169	1.52	No	Yes	2	9	5
449	R:R:L385	R:R:S409	1.5	No	No	0	8	9
450	R:R:L436	R:R:V439	1.49	No	No	0	4	5
451	R:R:L321	R:R:T218	1.47	No	Yes	0	6	7
452	R:R:L479	R:R:T478	1.47	No	No	0	4	4
453	R:R:I190	R:R:M189	1.46	No	No	0	6	4
454	R:R:I371	R:R:M425	1.46	Yes	Yes	0	7	6
455	R:R:Q401	R:R:T399	1.42	No	No	0	6	6
456	R:R:E177	R:R:T178	1.41	No	No	0	1	3
457	R:R:E391	R:R:T387	1.41	No	No	0	7	7
458	R:R:E431	R:R:T430	1.41	No	No	0	3	5
459	R:R:A165	R:R:R146	1.38	No	Yes	0	7	8
460	R:R:E391	R:R:K388	1.35	No	No	0	7	9
461	R:R:A188	R:R:Y191	1.33	No	Yes	0	5	7
462	R:R:D185	R:R:E182	1.3	No	No	0	2	2
463	R:R:R162	R:R:T163	1.29	No	No	0	3	5
464	R:R:R390	R:R:T387	1.29	No	No	0	6	7
465	R:R:R400	R:R:T399	1.29	No	No	0	8	6
466	R:R:H140	R:R:N139	1.28	No	No	0	3	4
467	L:L:H32	L:L:Q29	1.24	No	No	0	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:E4	5.5925	4	1	0
2	L:L:I5	5.5	4	1	0
3	L:L:Q6	6.684	5	1	0
4	L:L:M8	3.4	4	1	0
5	L:L:H14	8.095	4	8	0
6	L:L:R20	8.1425	4	7	0
7	L:L:W23	5.746	5	6	0
8	L:L:L24	8.8275	4	0	0
9	L:L:R25	3.4525	4	0	0
10	R:R:V31	6.06	4	7	6
11	R:R:K34	3.985	4	6	4
12	R:R:Q37	6.5025	4	0	7
13	R:R:C108	4.9575	4	3	9
14	R:R:I115	5.074	5	2	5
15	R:R:L116	6.0975	4	2	5
16	R:R:E125	4.7675	4	3	5
17	R:R:V127	5.2325	4	3	7
18	R:R:P132	5.16	7	2	9
19	R:R:Y134	5.1	7	2	5
20	R:R:I135	4.81	6	2	7
21	R:R:F138	6.60571	7	2	4
22	R:R:Y145	5.1825	4	5	4
23	R:R:R146	5.49	5	3	8
24	R:R:R147	4.47	4	5	3
25	R:R:C148	4.0225	4	3	9
26	R:R:W154	5.2725	4	3	9
27	R:R:E155	8.6025	4	5	4
28	R:R:W164	5.4575	4	5	5
29	R:R:Y167	4.7225	4	2	5
30	R:R:E169	3	4	2	5
31	R:R:V171	3.515	4	2	3
32	R:R:L187	3.83	4	0	5
33	R:R:Y191	5.054	5	0	7
34	R:R:Y195	6.25429	7	1	7
35	R:R:F212	5.12	5	0	7
36	R:R:T218	4.21	4	0	7
37	R:R:L226	5.985	4	1	9
38	R:R:F230	8.584	5	1	8
39	R:R:M231	3.985	4	0	8
40	R:R:R233	7.11667	6	1	8
41	R:R:K240	6.8475	4	1	7
42	R:R:L244	4.855	4	1	5
43	R:R:F288	6.736	5	1	7
44	R:R:L289	4.438	5	1	7
45	R:R:Y290	5.054	5	1	9
46	R:R:N295	11.4775	4	1	8
47	R:R:Y296	7.428	5	1	7
48	R:R:Y297	8.3175	4	1	6
49	R:R:W298	11.58	5	1	9
50	R:R:I299	5.7675	4	1	9
51	R:R:L300	6.7725	4	0	8
52	R:R:E302	8.17	4	0	9
53	R:R:Y305	9.38	4	0	8
54	R:R:L306	4.4075	4	4	9
55	R:R:I310	4.225	4	4	8
56	R:R:F311	5.31	4	4	6
57	R:R:W329	8.4275	4	1	9
58	R:R:P332	4.188	5	1	9
59	R:R:F335	5.62833	6	1	5
60	R:R:W339	6.484	5	1	8
61	R:R:V342	3.44	4	0	5
62	R:R:R343	6.2025	4	1	8
63	R:R:W352	11.242	5	1	8
64	R:R:K359	4.4125	4	1	3
65	R:R:W361	6.2975	4	1	8
66	R:R:Q364	8.095	4	1	7
67	R:R:I371	3.52	4	1	7
68	R:R:F378	9.305	4	4	9
69	R:R:L413	5.365	4	4	9
70	R:R:F417	8.40833	6	4	9
71	R:R:H420	9.54333	6	1	8
72	R:R:Y421	10.7114	7	1	8
73	R:R:F424	9.05	5	1	7
74	R:R:M425	3.37	4	0	6
75	R:R:Y429	9.736	5	1	6
76	R:R:W437	6.72429	7	1	5
77	R:R:M441	7.9525	4	1	6
78	R:R:Y443	7.586	5	1	4
79	R:R:E444	7.88	4	1	7
80	R:R:M445	5.19667	6	1	6
81	R:R:Q451	8.8025	4	1	9
82	R:R:Y459	7.3275	4	0	8
83	R:R:V466	4.2175	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:E4	R:R:M445	79.6116	8.12	Yes	Yes	1	0	6
2	L:L:L7	R:R:M445	83.9926	5.65	No	Yes	0	0	6
3	L:L:I5	R:R:L292	12.0662	2.85	Yes	No	1	0	6
4	R:R:L292	R:R:R233	11.0193	7.29	No	Yes	1	6	8
5	L:L:E4	R:R:R233	74.0423	4.65	Yes	Yes	1	0	8
6	L:L:I5	R:R:L289	10.0625	4.28	Yes	Yes	1	0	7
7	R:R:L244	R:R:Y245	15.2845	9.38	Yes	No	0	5	4
8	L:L:L11	R:R:Y245	14.8392	14.07	No	No	0	0	4
9	L:L:L11	R:R:F184	78.125	8.53	No	No	0	0	6
10	L:L:L11	L:L:L15	91.9865	4.15	No	No	0	0	0
11	L:L:M18	L:L:S17	99.2772	1.53	No	No	0	0	0
12	L:L:H14	L:L:M18	100	13.13	Yes	No	0	0	0
13	L:L:R20	L:L:S17	94.4747	3.95	Yes	No	7	0	0
14	L:L:L24	R:R:D137	10.4043	14.93	Yes	No	0	0	5
15	L:L:R20	R:R:D137	92.7265	13.1	Yes	No	0	0	5
16	R:R:D137	R:R:I135	82.1862	2.8	No	Yes	0	5	7
17	R:R:D113	R:R:W118	25.2839	5.58	No	No	0	9	9
18	R:R:L116	R:R:W118	69.6723	9.11	Yes	No	0	5	9
19	R:R:I115	R:R:L116	22.936	2.85	Yes	Yes	2	5	5
20	R:R:I115	R:R:I135	23.9216	2.94	Yes	Yes	2	5	7
21	R:R:L116	R:R:P132	24.1464	6.57	Yes	Yes	2	5	9
22	R:R:I135	R:R:P132	27.1828	5.08	Yes	Yes	2	7	9
23	R:R:L116	R:R:Y134	23.6931	5.86	Yes	Yes	2	5	5
24	R:R:I135	R:R:Y134	26.2175	6.04	Yes	Yes	2	7	5
25	R:R:V129	R:R:W118	43.5877	4.9	No	No	0	5	9
26	R:R:V127	R:R:V129	41.3409	3.21	Yes	No	0	7	5
27	R:R:E125	R:R:V127	27.8787	4.28	Yes	Yes	3	5	7
28	R:R:A122	R:R:E125	24.5948	7.54	No	Yes	0	1	5
29	R:R:A122	R:R:P123	23.4358	1.87	No	No	0	1	7
30	R:R:G105	R:R:P123	22.2757	4.06	No	No	0	5	7
31	R:R:G105	R:R:R106	21.1142	3	No	No	0	5	1
32	R:R:N151	R:R:R106	18.7877	10.85	No	No	0	5	1
33	R:R:D113	R:R:E111	16.2193	15.59	No	No	0	9	7
34	R:R:N151	R:R:S153	17.6227	4.47	No	No	0	5	4
35	R:R:R150	R:R:S153	16.4564	5.27	No	No	0	1	4
36	R:R:D149	R:R:R150	15.2888	13.1	No	No	0	5	1
37	R:R:D149	R:R:E155	14.1201	15.59	No	Yes	0	5	4
38	R:R:S449	R:R:Y195	13.5528	5.09	No	Yes	0	9	7
39	R:R:G194	R:R:S449	12.9017	1.86	No	No	0	9	9
40	R:R:G194	R:R:V193	12.2597	1.84	No	No	0	9	6
41	R:R:S196	R:R:V193	11.6447	1.62	No	No	0	7	6
42	R:R:S196	R:R:V197	11.0334	1.62	No	No	0	7	5
43	R:R:F453	R:R:V197	10.4239	9.18	No	No	0	6	5
44	R:R:N295	R:R:R233	86.498	13.26	Yes	Yes	1	8	8
45	R:R:F230	R:R:N295	27.8322	18.12	Yes	Yes	1	8	8
46	R:R:N295	R:R:S229	32.0098	7.45	Yes	No	0	8	9
47	R:R:L226	R:R:S229	29.7158	4.5	Yes	No	0	9	9
48	R:R:E302	R:R:L226	86.6928	9.28	Yes	Yes	0	9	9
49	R:R:E302	R:R:H223	35.1222	8.62	Yes	No	0	9	9
50	R:R:H223	R:R:R219	32.5856	11.28	No	No	0	9	9
51	R:R:N220	R:R:R219	18.136	6.03	No	No	0	9	9
52	R:R:L215	R:R:N220	17.2545	5.49	No	No	0	9	9
53	R:R:L215	R:R:V466	10.1709	4.47	No	Yes	0	9	9
54	R:R:C460	R:R:V466	16.7626	3.42	No	Yes	0	9	9
55	R:R:F230	R:R:L226	29.298	7.31	Yes	Yes	1	8	9
56	R:R:I299	R:R:N295	27.2515	7.08	Yes	Yes	1	9	8
57	R:R:I299	R:R:L226	29.0769	2.85	Yes	Yes	1	9	9
58	R:R:E465	R:R:R219	13.6049	5.82	No	No	0	9	9
59	R:R:E465	R:R:N463	12.724	5.26	No	No	0	9	9
60	R:R:N463	R:R:V466	10.0962	5.91	No	Yes	0	9	9
61	R:R:E302	R:R:I222	10.9378	6.83	Yes	No	0	9	9
62	R:R:I222	R:R:Y305	10.0404	8.46	No	Yes	0	9	8
63	R:R:T218	R:R:Y305	11.1908	7.49	Yes	Yes	0	7	8
64	R:R:E302	R:R:L416	46.6799	7.95	Yes	No	0	9	9
65	R:R:L289	R:R:W339	14.9752	4.56	Yes	Yes	1	7	8
66	R:R:F417	R:R:L416	43.7231	6.09	Yes	No	0	9	9
67	R:R:F417	R:R:L306	13.5608	4.87	Yes	Yes	4	9	9
68	R:R:I310	R:R:L306	11.8107	2.85	Yes	Yes	4	8	9
69	R:R:F378	R:R:F417	20.1936	12.86	Yes	Yes	4	9	9
70	R:R:F378	R:R:V382	14.811	7.87	Yes	No	0	9	7
71	R:R:T410	R:R:V382	13.8322	4.76	No	No	0	9	7
72	R:R:L406	R:R:T410	12.8521	2.95	No	No	0	8	9
73	R:R:L389	R:R:L406	10.8882	2.77	No	No	0	8	8
74	L:L:H14	L:L:L15	90.8	3.86	Yes	No	8	0	0
75	L:L:L7	R:R:F184	80.3406	3.65	No	No	0	0	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:V2	R:R:Q364	7.16	1	No	Yes	0	7	0	1
L:L:V2	R:R:I367	4.61	1	No	No	0	7	0	1
L:L:S3	R:R:E444	11.5	1	No	Yes	0	7	0	1
L:L:S3	R:R:M445	3.07	1	No	Yes	0	6	0	1
L:L:E4	R:R:Y195	6.73	1	Yes	Yes	0	7	0	1
L:L:E4	R:R:R233	4.65	1	Yes	Yes	0	8	0	1
L:L:E4	R:R:M445	8.12	1	Yes	Yes	0	6	0	1
L:L:I5	R:R:L289	4.28	1	Yes	Yes	0	7	0	1
L:L:I5	R:R:L292	2.85	1	Yes	No	0	6	0	1
L:L:I5	R:R:Q364	4.12	1	Yes	Yes	0	7	0	1
L:L:Q6	R:R:Y429	12.4	1	Yes	Yes	0	6	0	1
L:L:Q6	R:R:W437	3.29	1	Yes	Yes	0	5	0	1
L:L:Q6	R:R:M441	6.8	1	Yes	Yes	0	6	0	1
L:L:L7	R:R:F184	3.65	0	No	No	0	6	0	1
L:L:L7	R:R:M441	5.65	0	No	Yes	0	6	0	1
L:L:L7	R:R:M445	5.65	0	No	Yes	0	6	0	1
L:L:M8	R:R:K240	2.88	1	Yes	Yes	0	7	0	1
L:L:M8	R:R:L244	2.83	1	Yes	Yes	0	5	0	1
L:L:M8	R:R:F288	3.73	1	Yes	Yes	0	7	0	1
L:L:M8	R:R:D353	4.16	1	Yes	No	0	5	0	1
L:L:H9	R:R:S355	8.37	1	No	No	0	7	0	1
L:L:H9	R:R:K360	3.93	1	No	No	0	7	0	1
L:L:H9	R:R:Y429	4.36	1	No	Yes	0	6	0	1
L:L:N10	R:R:V432	4.43	1	No	No	0	5	0	1
L:L:N10	R:R:W437	7.91	1	No	Yes	0	5	0	1
L:L:L11	R:R:F184	8.53	0	No	No	0	6	0	1
L:L:L11	R:R:Y245	14.07	0	No	No	0	4	0	1
L:L:K13	R:R:V31	9.11	0	No	Yes	0	6	0	1
L:L:H14	R:R:E180	8.62	8	Yes	No	0	3	0	1
L:L:H14	R:R:R181	6.77	8	Yes	No	0	3	0	1
L:L:L15	R:R:R181	3.64	8	No	No	0	3	0	1
L:L:N16	R:R:T33	7.31	6	No	No	0	7	0	1
L:L:N16	R:R:E35	5.26	6	No	No	0	5	0	1
L:L:S17	R:R:V31	4.85	7	No	Yes	0	6	0	1
L:L:M18	R:R:E177	5.41	0	No	No	0	1	0	1
L:L:E19	R:R:K34	4.05	0	No	Yes	0	4	0	1
L:L:R20	R:R:V31	5.23	7	Yes	Yes	0	6	0	1
L:L:R20	R:R:Y136	10.29	7	Yes	No	0	4	0	1
L:L:R20	R:R:D137	13.1	7	Yes	No	0	5	0	1
L:L:W23	R:R:K34	3.48	6	Yes	Yes	0	4	0	1
L:L:W23	R:R:Q37	4.38	6	Yes	Yes	0	7	0	1
L:L:W23	R:R:I38	5.87	6	Yes	No	0	7	0	1
L:L:L24	R:R:D137	14.93	0	Yes	No	0	5	0	1
L:L:L24	R:R:F138	12.18	0	Yes	Yes	0	4	0	1
L:L:R25	R:R:V171	3.92	0	Yes	Yes	0	3	0	1
L:L:L28	R:R:F138	7.31	2	No	Yes	0	4	0	1
L:L:L28	R:R:V171	2.98	2	No	Yes	0	3	0	1
L:L:D30	R:R:H114	6.3	9	No	No	0	4	0	1
L:L:V31	R:R:D113	4.38	0	No	No	0	9	0	1
L:L:V31	R:R:H114	4.15	0	No	No	0	4	0	1
L:L:F34	R:R:H114	5.66	9	No	No	0	4	0	1
R:R:V31	R:R:Y136	5.05	7	Yes	No	6	4	1	1
R:R:E36	R:R:M32	10.83	0	No	No	6	6	2	2
R:R:M32	R:R:Q37	4.08	0	No	Yes	6	7	2	1
R:R:M32	R:R:Y136	5.99	0	No	No	6	4	2	1
R:R:E35	R:R:T33	12.7	6	No	No	5	7	1	1
R:R:E36	R:R:T33	15.52	0	No	No	6	7	2	1
R:R:E35	R:R:K34	4.05	6	No	Yes	5	4	1	1
R:R:I38	R:R:K34	4.36	6	No	Yes	7	4	1	1
R:R:L40	R:R:Q37	9.32	0	No	Yes	5	7	2	1
R:R:I135	R:R:Q37	8.23	2	Yes	Yes	7	7	2	1
R:R:D113	R:R:E111	15.59	0	No	No	9	7	1	2
R:R:D113	R:R:W118	5.58	0	No	No	9	9	1	2
R:R:I135	R:R:P132	5.08	2	Yes	Yes	7	9	2	2
R:R:F138	R:R:P132	8.67	2	Yes	Yes	4	9	1	2
R:R:P132	R:R:Y167	2.78	2	Yes	Yes	9	5	2	2
R:R:D137	R:R:I135	2.8	0	No	Yes	5	7	1	2
R:R:F138	R:R:I135	3.77	2	Yes	Yes	4	7	1	2
R:R:F138	R:R:Y167	6.19	2	Yes	Yes	4	5	1	2
R:R:C170	R:R:F138	4.19	2	No	Yes	9	4	2	1
R:R:F138	R:R:V171	3.93	2	Yes	Yes	4	3	1	1
R:R:S168	R:R:V171	3.23	0	No	Yes	6	3	2	1
R:R:E180	R:R:V432	5.7	0	No	No	3	5	1	1
R:R:D185	R:R:R181	9.53	0	No	No	2	3	2	1
R:R:F184	R:R:W437	4.01	0	No	Yes	6	5	1	1
R:R:L187	R:R:M441	4.24	0	Yes	Yes	5	6	2	1
R:R:L187	R:R:M445	4.24	0	Yes	Yes	5	6	2	1
R:R:I190	R:R:M445	2.92	0	No	Yes	6	6	2	1
R:R:Y191	R:R:Y195	4.96	0	Yes	Yes	7	7	2	1
R:R:D241	R:R:Y191	8.05	0	No	Yes	8	7	2	2
R:R:M445	R:R:Y191	7.18	1	Yes	Yes	6	7	1	2
R:R:R233	R:R:Y195	11.32	1	Yes	Yes	8	7	1	1
R:R:A234	R:R:Y195	5.34	1	No	Yes	8	7	2	1
R:R:I237	R:R:Y195	7.25	0	No	Yes	7	7	2	1
R:R:F238	R:R:Y195	3.09	1	No	Yes	7	7	2	1
R:R:S449	R:R:Y195	5.09	0	No	Yes	9	7	2	1
R:R:L292	R:R:R233	7.29	1	No	Yes	6	8	1	1
R:R:N295	R:R:R233	13.26	1	Yes	Yes	8	8	2	1
R:R:R233	R:R:Y296	3.09	1	Yes	Yes	8	7	1	2
R:R:R233	R:R:Y421	3.09	1	Yes	Yes	8	8	1	2
R:R:A234	R:R:F238	2.77	1	No	No	8	7	2	2
R:R:F288	R:R:S236	3.96	1	Yes	No	7	7	1	2
R:R:F288	R:R:I237	3.77	1	Yes	No	7	7	1	2
R:R:D241	R:R:K240	4.15	0	No	Yes	8	7	2	1
R:R:K240	R:R:L244	4.23	1	Yes	Yes	7	5	1	1
R:R:F288	R:R:K240	16.13	1	Yes	Yes	7	7	1	1
R:R:L244	R:R:Y245	9.38	1	Yes	No	5	4	1	1
R:R:L244	R:R:V285	2.98	1	Yes	No	5	6	1	2
R:R:L289	R:R:V285	2.98	1	Yes	No	7	6	1	2
R:R:F288	R:R:L289	6.09	1	Yes	Yes	7	7	1	1
R:R:L289	R:R:W339	4.56	1	Yes	Yes	7	8	1	2
R:R:I363	R:R:L289	4.28	1	No	Yes	7	7	2	1
R:R:L292	R:R:Y296	5.86	1	No	Yes	6	7	1	2
R:R:I367	R:R:Y296	8.46	1	No	Yes	7	7	1	2
R:R:I371	R:R:Y296	4.84	1	Yes	Yes	7	7	2	2
R:R:Y296	R:R:Y421	14.89	1	Yes	Yes	7	8	2	2
R:R:I363	R:R:W339	10.57	1	No	Yes	7	8	2	2
R:R:C351	R:R:D353	4.67	0	No	No	9	5	2	1
R:R:D353	R:R:L354	6.79	0	No	No	5	5	1	1
R:R:K360	R:R:W361	8.12	1	No	Yes	7	8	1	2
R:R:K360	R:R:Y429	17.91	1	No	Yes	7	6	1	1
R:R:Q364	R:R:W361	10.95	1	Yes	Yes	7	8	1	2
R:R:W361	R:R:Y429	3.86	1	Yes	Yes	8	6	2	1
R:R:Q364	R:R:Y429	10.15	1	Yes	Yes	7	6	1	1
R:R:I367	R:R:I371	2.94	1	No	Yes	7	7	1	2
R:R:I371	R:R:Y421	4.84	1	Yes	Yes	7	8	2	2
R:R:N448	R:R:Y421	16.28	1	No	Yes	6	8	2	2
R:R:F424	R:R:Y443	7.22	1	Yes	Yes	7	4	2	2
R:R:E444	R:R:F424	3.5	1	Yes	Yes	7	7	1	2
R:R:T430	R:R:W437	3.64	0	No	Yes	5	5	2	1
R:R:V432	R:R:W437	9.81	1	No	Yes	5	5	1	1
R:R:Q438	R:R:W437	3.29	0	No	Yes	4	5	2	1
R:R:M441	R:R:W437	15.12	1	Yes	Yes	6	5	1	1
R:R:E444	R:R:Y443	3.37	1	Yes	Yes	7	4	1	2
R:R:E444	R:R:N448	13.15	1	Yes	No	7	6	1	2
L:L:G12	R:R:L354	1.71	0	No	No	0	5	0	1
R:R:E177	R:R:T178	1.41	0	No	No	1	3	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8HA0_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.77
Number of Linked Nodes	373
Number of Links	467
Number of Hubs	83
Number of Links mediated by Hubs	282
Number of Communities	9
Number of Nodes involved in Communities	111
Number of Links involved in Communities	170

Path Summary
Number Of Nodes in MetaPath	76
Number Of Links MetaPath	75
Number of Shortest Paths	271037
Length Of Smallest Path	3
Average Path Length	21.2949
Length of Longest Path	46
Minimum Path Strength	1.35
Average Path Strength	6.54051
Maximum Path Strength	19.425
Minimum Path Correlation	0.7
Average Path Correlation	0.964165
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	60.538
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.0398
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• cytoskeletal protein binding • spectrin binding • protein-containing complex binding • protein binding • binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to stimulus • response to stimulus • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to stress • response to chemical • response to oxygen levels • response to abiotic stimulus • cellular process • cell population proliferation • regulation of biological process • regulation of cellular process • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • intracellular anatomical structure • cytoplasm • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • organelle • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • synapse • cell junction • cell body • protein binding • binding • G-protein beta-subunit binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cellular process • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • parathyroid hormone receptor binding • signaling receptor binding • G protein-coupled receptor binding • type 1 parathyroid hormone receptor binding • molecular function activator activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • peptide hormone receptor binding • hormone receptor binding • hormone activity • response to xenobiotic stimulus • response to parathyroid hormone • magnesium ion homeostasis • inorganic ion homeostasis • chemical homeostasis • homeostatic process • monoatomic ion homeostasis • monoatomic cation homeostasis • developmental process • multicellular organismal process • ossification • bone mineralization • animal organ development • anatomical structure development • biomineral tissue development • tissue development • multicellular organismal-level homeostasis • homeostasis of number of cells within a tissue • anatomical structure homeostasis • tissue homeostasis • homeostasis of number of cells • biosynthetic process • metabolic process • macromolecule metabolic process • macromolecule biosynthetic process • multicellular organism development • skeletal system development • system development • regulation of biosynthetic process • positive regulation of biological process • regulation of macromolecule metabolic process • gene expression • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • positive regulation of macromolecule metabolic process • regulation of metabolic process • positive regulation of cellular process • RNA metabolic process • primary metabolic process • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • RNA biosynthetic process • nucleobase-containing compound metabolic process • DNA-templated transcription • nucleic acid biosynthetic process • transcription by RNA polymerase II • negative regulation of apoptotic process in bone marrow cell • negative regulation of programmed cell death • apoptotic process in bone marrow cell • regulation of apoptotic process in bone marrow cell • regulation of apoptotic process • negative regulation of biological process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • negative regulation of cellular process • apoptotic process • programmed cell death • regulation of generation of precursor metabolites and energy • regulation of primary metabolic process • positive regulation of glycogen metabolic process • regulation of small molecule metabolic process • small molecule metabolic process • carbohydrate biosynthetic process • hexose metabolic process • positive regulation of glucose metabolic process • positive regulation of glycogen biosynthetic process • energy reserve metabolic process • positive regulation of carbohydrate metabolic process • regulation of glycogen metabolic process • monosaccharide metabolic process • regulation of glycogen biosynthetic process • glucan biosynthetic process • energy derivation by oxidation of organic compounds • regulation of glucan biosynthetic process • regulation of polysaccharide metabolic process • polysaccharide metabolic process • glucan metabolic process • regulation of carbohydrate metabolic process • regulation of glucose metabolic process • carbohydrate metabolic process • polysaccharide biosynthetic process • glycogen metabolic process • generation of precursor metabolites and energy • glycogen biosynthetic process • regulation of polysaccharide biosynthetic process • regulation of carbohydrate biosynthetic process • positive regulation of small molecule metabolic process • glucose metabolic process • phosphate ion homeostasis • cell-cell signaling • intracellular calcium ion homeostasis • calcium ion homeostasis • cellular homeostasis • intracellular monoatomic cation homeostasis • intracellular chemical homeostasis • intracellular monoatomic ion homeostasis • regulation of developmental process • regulation of biomineral tissue development • regulation of bone mineralization • positive regulation of ossification • positive regulation of developmental process • positive regulation of biomineral tissue development • regulation of multicellular organismal process • regulation of multicellular organismal development • positive regulation of bone mineralization • positive regulation of multicellular organismal process • regulation of ossification • response to ethanol • response to metal ion • response to lead ion • cell population proliferation • positive regulation of cell population proliferation • positive regulation of cell proliferation in bone marrow • cell proliferation in bone marrow • regulation of cell proliferation in bone marrow • regulation of cell population proliferation • response to nutrient levels • response to vitamin D • response to nutrient • response to vitamin • hormone-mediated signaling pathway • apoptotic signaling pathway • hormone-mediated apoptotic signaling pathway • nucleoside phosphate metabolic process • ribose phosphate metabolic process • cAMP metabolic process • cyclic purine nucleotide metabolic process • carbohydrate derivative metabolic process • nucleotide metabolic process • cyclic nucleotide metabolic process • purine-containing compound metabolic process • purine nucleotide metabolic process • ribonucleotide metabolic process • organophosphate metabolic process • nucleobase-containing small molecule metabolic process • phosphate-containing compound metabolic process • purine ribonucleotide metabolic process • phosphorus metabolic process • regulation of cartilage development • regulation of chondrocyte differentiation • connective tissue development • cellular developmental process • negative regulation of cartilage development • negative regulation of chondrocyte differentiation • regulation of cell differentiation • cell differentiation • negative regulation of cell differentiation • negative regulation of developmental process • chondrocyte differentiation • negative regulation of multicellular organismal process • cartilage development • negative regulation of metabolic process • negative regulation of gene expression • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of macromolecule metabolic process • regulation of localization • hexose transmembrane transport • D-glucose import • transport • carbohydrate transport • positive regulation of D-glucose transmembrane transport • localization • positive regulation of transmembrane transport • regulation of D-glucose import • positive regulation of D-glucose import • regulation of transport • establishment of localization • transmembrane transport • regulation of transmembrane transport • positive regulation of transport • D-glucose transmembrane transport • regulation of D-glucose transmembrane transport • monosaccharide transmembrane transport • carbohydrate transmembrane transport • positive regulation of cell communication • regulation of signaling • positive regulation of signal transduction • regulation of signal transduction • positive regulation of response to stimulus • regulation of response to stimulus • regulation of cell communication • positive regulation of signaling • response to cadmium ion • small GTPase-mediated signal transduction • Rho protein signal transduction • intracellular signal transduction • intracellular signaling cassette • regulation of leukocyte proliferation • osteoclast proliferation • regulation of osteoclast proliferation • positive regulation of osteoclast proliferation • leukocyte proliferation • positive regulation of leukocyte proliferation • bone maturation • regulation of bone mineralization involved in bone maturation • negative regulation of biomineral tissue development • negative regulation of bone mineralization • ossification involved in bone maturation • bone development • bone mineralization involved in bone maturation • developmental maturation • negative regulation of bone mineralization involved in bone maturation • negative regulation of ossification • anatomical structure maturation • animal organ maturation • positive regulation of DNA-templated transcription • regulation of RNA metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of transcription by RNA polymerase II • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • regulation of inositol phosphate biosynthetic process • alcohol metabolic process • positive regulation of phosphate metabolic process • inositol phosphate metabolic process • polyol biosynthetic process • polyol metabolic process • positive regulation of phosphorus metabolic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • positive regulation of inositol phosphate biosynthetic process • organophosphate biosynthetic process • inositol phosphate biosynthetic process • alcohol biosynthetic process • regulation of phosphorus metabolic process • positive regulation of alcohol biosynthetic process • tissue remodeling • bone remodeling • bone resorption • response to fibroblast growth factor • response to growth factor • extracellular region • extracellular space • identical protein binding • protein homodimerization activity • protein dimerization activity • amide binding • peptide hormone binding • hormone binding • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • parathyroid hormone receptor activity • osteoblast development • cell development • osteoblast differentiation • embryo development ending in birth or egg hatching • chordate embryonic development • embryo development • in utero embryonic development • cell maturation • cell surface receptor signaling pathway • negative regulation of cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • membraneless organelle • nuclear lumen • apical part of cell • apical plasma membrane • cytosol • basal part of cell • basal plasma membrane • basolateral plasma membrane • receptor complex
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q03431
Sequence	>8HA0_nogp_Chain_R V M T K E E Q I F L L H R A Q A Q C E K G R P C L P E W D H I L C W P L G A P G E V V A V P C P D Y I Y D F N H K G H A Y R R C D R N G S W E L V P G H N R T W A N Y S E C V K E T R E R E V F D R L A M I Y T V G Y S V S L A S L T V A V L I L A Y F R R L H C T R N Y I H M H L F L S F M L R A V S I F V K D A V L Y S A G Y A G C R V A V T F F L Y F L A T N Y Y W I L V E G L Y L H S L I F M A F F S E K K Y L W G F T V F G W G L P A V F V A V W V S V R A T L A N T G C W D L S S G N K K W I I Q V P I L A S I V L N F I L F I N I V R V L A T K L R E T N T R Q Q Y R K L L K S T L V L M P L F G V H Y I V F M A T P Y T E V S G T L W Q V Q M H Y E M L F N S F Q G F F V A I I Y C F C N G E V Q A E I K K S W S R W T L A L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8GW8	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371	Gs/β1/γ2	2.9	2023-06-14	doi.org/10.1038/s41586-023-06169-3
	8GW8 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371		2.9	2023-06-14	doi.org/10.1038/s41586-023-06169-3
	8JR9	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371	chim(NtGi1-Gs)/β1/γ2	2.57	2023-08-02	doi.org/10.1038/s41586-023-06467-w
	8JR9 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371		2.57	2023-08-02	doi.org/10.1038/s41586-023-06467-w
	7VVJ	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/β1/γ2	3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVJ (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVK	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.3	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVK (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.3	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVL	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVL (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVM	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVM (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVN	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVN (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	4.1	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		4.1	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	8FLQ	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.55	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLQ (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.55	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLR	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/β1/γ2	2.94	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLR (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		2.94	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLS	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/β1/γ2	3.09	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLS (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-		3.09	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLT	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	M-PTH(1-14)	-	Gs/β1/γ2	3.03	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLT (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	M-PTH(1-14)	-		3.03	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLU	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-	Gs/β1/γ2	2.76	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLU (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-		2.76	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8HA0	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/β1/γ2	2.62	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HA0 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.62	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAF	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	chim(NtGi1-Gs)/β1/γ2	3.25	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAF (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		3.25	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/β1/γ2	3.76	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.76	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	6FJ3	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	-	2.5	2018-11-21	doi.org/10.1038/s41594-018-0151-4
	6NBF	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	3	2019-04-17	doi.org/10.1126/science.aav7942
	6NBF (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		3	2019-04-17	doi.org/10.1126/science.aav7942
	6NBH	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	3.5	2019-04-17	doi.org/10.1126/science.aav7942
	6NBH (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		3.5	2019-04-17	doi.org/10.1126/science.aav7942
	6NBI	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	4	2019-04-17	doi.org/10.1126/science.aav7942
	6NBI (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		4	2019-04-17	doi.org/10.1126/science.aav7942
	9B5Y	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-	chim(NtGi1-Gq)/β1/γ2	3.49	2025-03-19	doi.org/10.1073/pnas.2426178122
	9B5Y (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-		3.49	2025-03-19	doi.org/10.1073/pnas.2426178122
	7Y35	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/β1/γ2	2.9	2023-07-05	To be published
	7Y35 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-		2.9	2023-07-05	To be published
	7Y36	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Teriparatide	-	Gs/β1/γ2	2.8	2023-07-05	To be published
	7Y36 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Teriparatide	-		2.8	2023-07-05	To be published
	9JR2	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-10-16	To be published
	9JR2 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2024-10-16	To be published
	9JR3	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-10-16	To be published
	9JR3 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2024-10-16	To be published

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Download 8HA0_nogp.zip

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