psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:Q6	L:L:S1	4.33	Yes	No	0	0	0
2	L:L:I5	L:L:V2	10.75	Yes	No	1	0	0
3	L:L:V2	R:R:Q364	7.16	No	Yes	1	0	7
4	L:L:V2	R:R:I367	4.61	No	No	1	0	7
5	L:L:E4	L:L:S3	2.87	Yes	No	1	0	0
6	L:L:S3	R:R:E444	11.5	No	Yes	1	0	7
7	L:L:S3	R:R:M445	3.07	No	Yes	1	0	6
8	L:L:E4	R:R:Y195	6.73	Yes	Yes	1	0	7
9	L:L:E4	R:R:R233	4.65	Yes	Yes	1	0	8
10	L:L:E4	R:R:M445	8.12	Yes	Yes	1	0	6
11	L:L:I5	R:R:L289	4.28	Yes	Yes	1	0	7
12	L:L:I5	R:R:L292	2.85	Yes	No	1	0	6
13	L:L:I5	R:R:Q364	4.12	Yes	Yes	1	0	7
14	L:L:N10	L:L:Q6	6.6	No	Yes	1	0	0
15	L:L:Q6	R:R:Y429	12.4	Yes	Yes	1	0	6
16	L:L:Q6	R:R:W437	3.29	Yes	Yes	1	0	5
17	L:L:Q6	R:R:M441	6.8	Yes	Yes	1	0	6
18	L:L:L7	R:R:F184	3.65	No	No	0	0	6
19	L:L:L7	R:R:M441	5.65	No	Yes	0	0	6
20	L:L:L7	R:R:M445	5.65	No	Yes	0	0	6
21	L:L:M8	R:R:K240	2.88	Yes	Yes	1	0	7
22	L:L:M8	R:R:L244	2.83	Yes	Yes	1	0	5
23	L:L:M8	R:R:F288	3.73	Yes	Yes	1	0	7
24	L:L:M8	R:R:D353	4.16	Yes	No	0	0	5
25	L:L:H9	R:R:S355	8.37	No	No	0	0	7
26	L:L:H9	R:R:K360	3.93	No	No	1	0	7
27	L:L:H9	R:R:Y429	4.36	No	Yes	1	0	6
28	L:L:N10	R:R:V432	4.43	No	No	1	0	5
29	L:L:N10	R:R:W437	7.91	No	Yes	1	0	5
30	L:L:L11	L:L:L15	4.15	No	No	0	0	0
31	L:L:L11	R:R:F184	8.53	No	No	0	0	6
32	L:L:L11	R:R:Y245	14.07	No	No	0	0	4
33	L:L:K13	L:L:N16	4.2	No	No	0	0	0
34	L:L:K13	R:R:V31	9.11	No	Yes	0	0	6
35	L:L:H14	L:L:L15	3.86	Yes	No	8	0	0
36	L:L:H14	L:L:M18	13.13	Yes	No	0	0	0
37	L:L:H14	R:R:E180	8.62	Yes	No	0	0	3
38	L:L:H14	R:R:R181	6.77	Yes	No	8	0	3
39	L:L:L15	R:R:R181	3.64	No	No	8	0	3
40	L:L:N16	R:R:T33	7.31	No	No	6	0	7
41	L:L:N16	R:R:E35	5.26	No	No	6	0	5
42	L:L:R20	L:L:S17	3.95	Yes	No	7	0	0
43	L:L:S17	R:R:V31	4.85	No	Yes	7	0	6
44	L:L:M18	R:R:E177	5.41	No	No	0	0	1
45	L:L:E19	R:R:K34	4.05	No	Yes	0	0	4
46	L:L:R20	R:R:V31	5.23	Yes	Yes	7	0	6
47	L:L:R20	R:R:Y136	10.29	Yes	No	7	0	4
48	L:L:R20	R:R:D137	13.1	Yes	No	0	0	5
49	L:L:R25	L:L:V21	3.92	Yes	No	0	0	0
50	L:L:L24	L:L:W23	4.56	Yes	Yes	0	0	0
51	L:L:K27	L:L:W23	10.44	No	Yes	0	0	0
52	L:L:W23	R:R:K34	3.48	Yes	Yes	6	0	4
53	L:L:W23	R:R:Q37	4.38	Yes	Yes	0	0	7
54	L:L:W23	R:R:I38	5.87	Yes	No	6	0	7
55	L:L:L24	L:L:R25	3.64	Yes	Yes	0	0	0
56	L:L:L24	R:R:D137	14.93	Yes	No	0	0	5
57	L:L:L24	R:R:F138	12.18	Yes	Yes	0	0	4
58	L:L:R25	R:R:V171	3.92	Yes	Yes	0	0	3
59	L:L:L28	R:R:F138	7.31	No	Yes	2	0	4
60	L:L:L28	R:R:V171	2.98	No	Yes	2	0	3
61	L:L:D30	L:L:F34	9.55	No	No	9	0	0
62	L:L:D30	R:R:H114	6.3	No	No	9	0	4
63	L:L:V31	R:R:D113	4.38	No	No	0	0	9
64	L:L:V31	R:R:H114	4.15	No	No	0	0	4
65	L:L:H32	L:L:N33	7.65	No	No	0	0	0
66	L:L:F34	L:L:N33	15.71	No	No	0	0	0
67	L:L:F34	R:R:H114	5.66	No	No	9	0	4
68	R:R:V31	R:R:Y136	5.05	Yes	No	7	6	4
69	R:R:E36	R:R:M32	10.83	No	No	0	6	6
70	R:R:M32	R:R:Q37	4.08	No	Yes	0	6	7
71	R:R:M32	R:R:Y136	5.99	No	No	0	6	4
72	R:R:E35	R:R:T33	12.7	No	No	6	5	7
73	R:R:E36	R:R:T33	15.52	No	No	0	6	7
74	R:R:E35	R:R:K34	4.05	No	Yes	6	5	4
75	R:R:I38	R:R:K34	4.36	No	Yes	6	7	4
76	R:R:L40	R:R:Q37	9.32	No	Yes	0	5	7
77	R:R:I135	R:R:Q37	8.23	Yes	Yes	0	7	7
78	R:R:L40	R:R:Y134	3.52	No	Yes	0	5	5
79	R:R:L41	R:R:Y134	3.52	No	Yes	0	8	5
80	R:R:H42	R:R:Q45	19.78	No	No	0	4	7
81	R:R:A44	R:R:R43	2.77	No	No	0	7	4
82	R:R:Q47	R:R:R43	8.18	No	No	0	6	4
83	R:R:A44	R:R:Y134	5.34	No	Yes	0	7	5
84	R:R:E49	R:R:Q45	8.92	No	No	0	6	7
85	R:R:A46	R:R:E49	3.02	No	No	0	5	6
86	R:R:C117	R:R:C48	7.28	No	No	0	9	8
87	R:R:G105	R:R:R106	3	No	No	0	5	1
88	R:R:G105	R:R:P123	4.06	No	No	0	5	7
89	R:R:P107	R:R:R106	2.88	No	No	0	3	1
90	R:R:N151	R:R:R106	10.85	No	No	0	5	1
91	R:R:C108	R:R:G121	3.92	Yes	No	0	9	7
92	R:R:C108	R:R:C148	5.46	Yes	Yes	3	9	9
93	R:R:C108	R:R:G152	3.92	Yes	No	3	9	9
94	R:R:C108	R:R:W154	6.53	Yes	Yes	3	9	9
95	R:R:L109	R:R:P110	4.93	No	No	0	5	6
96	R:R:D113	R:R:E111	15.59	No	No	0	9	7
97	R:R:E111	R:R:R146	5.82	No	Yes	0	7	8
98	R:R:E111	R:R:T163	7.06	No	No	0	7	5
99	R:R:C117	R:R:W112	7.84	No	No	0	9	7
100	R:R:D113	R:R:W118	5.58	No	No	0	9	9
101	R:R:I115	R:R:L116	2.85	Yes	Yes	2	5	5
102	R:R:I115	R:R:P132	5.08	Yes	Yes	2	5	9
103	R:R:I115	R:R:Y134	7.25	Yes	Yes	2	5	5
104	R:R:I115	R:R:I135	2.94	Yes	Yes	2	5	7
105	R:R:I115	R:R:Y167	7.25	Yes	Yes	2	5	5
106	R:R:L116	R:R:W118	9.11	Yes	No	0	5	9
107	R:R:L116	R:R:P132	6.57	Yes	Yes	2	5	9
108	R:R:L116	R:R:Y134	5.86	Yes	Yes	2	5	5
109	R:R:V129	R:R:W118	4.9	No	No	0	5	9
110	R:R:E125	R:R:L120	3.98	Yes	No	3	5	4
111	R:R:L120	R:R:V127	2.98	No	Yes	3	4	7
112	R:R:E125	R:R:G121	3.27	Yes	No	0	5	7
113	R:R:A122	R:R:E125	7.54	No	Yes	0	1	5
114	R:R:G124	R:R:R147	3	No	Yes	0	7	3
115	R:R:E125	R:R:V127	4.28	Yes	Yes	3	5	7
116	R:R:V126	R:R:Y145	3.79	No	Yes	5	4	4
117	R:R:R147	R:R:V126	3.92	Yes	No	5	3	4
118	R:R:V127	R:R:V129	3.21	Yes	No	0	7	5
119	R:R:R146	R:R:V127	10.46	Yes	Yes	3	8	7
120	R:R:A128	R:R:H143	5.85	No	No	0	5	3
121	R:R:P130	R:R:V129	3.53	No	No	0	5	5
122	R:R:C131	R:R:P132	3.77	No	Yes	2	9	9
123	R:R:C131	R:R:C170	7.28	No	No	2	9	9
124	R:R:P132	R:R:Y134	4.17	Yes	Yes	2	9	5
125	R:R:I135	R:R:P132	5.08	Yes	Yes	2	7	9
126	R:R:F138	R:R:P132	8.67	Yes	Yes	2	4	9
127	R:R:P132	R:R:Y167	2.78	Yes	Yes	2	9	5
128	R:R:D133	R:R:H140	12.61	No	No	0	2	3
129	R:R:I135	R:R:Y134	6.04	Yes	Yes	2	7	5
130	R:R:D137	R:R:I135	2.8	No	Yes	0	5	7
131	R:R:F138	R:R:I135	3.77	Yes	Yes	2	4	7
132	R:R:F138	R:R:Y167	6.19	Yes	Yes	2	4	5
133	R:R:C170	R:R:F138	4.19	No	Yes	2	9	4
134	R:R:F138	R:R:V171	3.93	Yes	Yes	2	4	3
135	R:R:K141	R:R:N139	6.99	No	No	0	3	4
136	R:R:E169	R:R:K141	4.05	Yes	No	0	5	3
137	R:R:G142	R:R:H143	4.77	No	No	0	5	3
138	R:R:E169	R:R:G142	4.91	Yes	No	0	5	5
139	R:R:R147	R:R:Y145	5.14	Yes	Yes	5	3	4
140	R:R:W164	R:R:Y145	4.82	Yes	Yes	5	5	4
141	R:R:N166	R:R:Y145	6.98	No	Yes	5	7	4
142	R:R:C148	R:R:R146	2.79	Yes	Yes	3	9	8
143	R:R:R146	R:R:W154	7	Yes	Yes	3	8	9
144	R:R:E155	R:R:R147	5.82	Yes	Yes	5	4	3
145	R:R:C148	R:R:G152	3.92	Yes	No	3	9	9
146	R:R:C148	R:R:W154	3.92	Yes	Yes	3	9	9
147	R:R:D149	R:R:R150	13.1	No	No	0	5	1
148	R:R:D149	R:R:E155	15.59	No	Yes	0	5	4
149	R:R:R150	R:R:S153	5.27	No	No	0	1	4
150	R:R:N151	R:R:S153	4.47	No	No	0	5	4
151	R:R:T163	R:R:W154	3.64	No	Yes	0	5	9
152	R:R:E155	R:R:V157	4.28	Yes	No	5	4	4
153	R:R:E155	R:R:W164	8.72	Yes	Yes	5	4	5
154	R:R:P158	R:R:V157	5.3	No	No	0	4	4
155	R:R:V157	R:R:W164	4.9	No	Yes	5	4	5
156	R:R:N161	R:R:P158	8.15	No	No	0	7	4
157	R:R:H160	R:R:R162	3.39	No	No	0	4	3
158	R:R:N166	R:R:W164	3.39	No	Yes	5	7	5
159	R:R:S168	R:R:V171	3.23	No	Yes	0	6	3
160	R:R:E180	R:R:V432	5.7	No	No	0	3	5
161	R:R:D185	R:R:R181	9.53	No	No	0	2	3
162	R:R:R186	R:R:V183	5.23	No	No	0	5	4
163	R:R:L187	R:R:V183	2.98	Yes	No	0	5	4
164	R:R:F184	R:R:W437	4.01	No	Yes	0	6	5
165	R:R:H442	R:R:R186	4.51	No	No	0	5	5
166	R:R:L187	R:R:M441	4.24	Yes	Yes	0	5	6
167	R:R:H442	R:R:L187	3.86	No	Yes	0	5	5
168	R:R:L187	R:R:M445	4.24	Yes	Yes	0	5	6
169	R:R:I190	R:R:M445	2.92	No	Yes	0	6	6
170	R:R:T192	R:R:Y191	3.75	No	Yes	0	7	7
171	R:R:Y191	R:R:Y195	4.96	Yes	Yes	0	7	7
172	R:R:D241	R:R:Y191	8.05	No	Yes	0	8	7
173	R:R:M445	R:R:Y191	7.18	Yes	Yes	0	6	7
174	R:R:R233	R:R:Y195	11.32	Yes	Yes	1	8	7
175	R:R:A234	R:R:Y195	5.34	No	Yes	1	8	7
176	R:R:I237	R:R:Y195	7.25	No	Yes	0	7	7
177	R:R:F238	R:R:Y195	3.09	No	Yes	1	7	7
178	R:R:S449	R:R:Y195	5.09	No	Yes	0	9	7
179	R:R:F453	R:R:V197	9.18	No	No	0	6	5
180	R:R:G452	R:R:S198	3.71	No	No	0	9	9
181	R:R:L199	R:R:M231	4.24	No	Yes	0	7	8
182	R:R:L199	R:R:V235	2.98	No	No	0	7	4
183	R:R:F453	R:R:S201	5.28	No	No	0	6	8
184	R:R:A456	R:R:S201	3.42	No	No	0	8	8
185	R:R:F227	R:R:L202	4.87	No	No	0	9	9
186	R:R:L202	R:R:M231	5.65	No	Yes	0	9	8
187	R:R:A456	R:R:L202	3.15	No	No	0	8	9
188	R:R:L207	R:R:T203	2.95	No	No	0	3	3
189	R:R:M231	R:R:T203	3.01	Yes	No	0	8	3
190	R:R:A205	R:R:F227	2.77	No	No	0	9	9
191	R:R:A205	R:R:C460	3.61	No	No	0	9	9
192	R:R:F227	R:R:V206	3.93	No	No	0	9	5
193	R:R:M231	R:R:V206	3.04	Yes	No	0	8	5
194	R:R:L209	R:R:M224	4.24	No	No	0	7	5
195	R:R:C460	R:R:L209	4.76	No	No	0	9	7
196	R:R:F212	R:R:L215	4.87	Yes	No	0	7	9
197	R:R:E469	R:R:F212	10.49	No	Yes	0	9	7
198	R:R:F212	R:R:I470	3.77	Yes	No	0	7	5
199	R:R:F212	R:R:S473	3.96	Yes	No	0	7	4
200	R:R:H216	R:R:R213	7.9	No	No	0	8	8
201	R:R:E469	R:R:R214	10.47	No	No	0	9	7
202	R:R:K472	R:R:R214	4.95	No	No	0	7	7
203	R:R:L215	R:R:N220	5.49	No	No	0	9	9
204	R:R:L215	R:R:V466	4.47	No	Yes	0	9	9
205	R:R:H216	R:R:Y221	5.44	No	No	0	8	7
206	R:R:C217	R:R:T218	3.38	No	Yes	0	8	7
207	R:R:T218	R:R:Y305	7.49	Yes	Yes	0	7	8
208	R:R:K318	R:R:T218	4.5	No	Yes	0	5	7
209	R:R:N220	R:R:R219	6.03	No	No	0	9	9
210	R:R:H223	R:R:R219	11.28	No	No	0	9	9
211	R:R:E465	R:R:R219	5.82	No	No	0	9	9
212	R:R:E302	R:R:I222	6.83	Yes	No	0	9	9
213	R:R:I222	R:R:Y305	8.46	No	Yes	0	9	8
214	R:R:E302	R:R:H223	8.62	Yes	No	0	9	9
215	R:R:H223	R:R:Y459	5.44	No	Yes	0	9	8
216	R:R:H225	R:R:W298	20.1	No	Yes	1	8	9
217	R:R:H225	R:R:W329	3.17	No	Yes	1	8	9
218	R:R:L226	R:R:S229	4.5	Yes	No	0	9	9
219	R:R:F230	R:R:L226	7.31	Yes	Yes	1	8	9
220	R:R:I299	R:R:L226	2.85	Yes	Yes	1	9	9
221	R:R:E302	R:R:L226	9.28	Yes	Yes	0	9	9
222	R:R:L228	R:R:L232	5.54	No	No	0	4	8
223	R:R:N295	R:R:S229	7.45	Yes	No	0	8	9
224	R:R:S229	R:R:W298	8.65	No	Yes	0	9	9
225	R:R:F230	R:R:N295	18.12	Yes	Yes	1	8	8
226	R:R:F230	R:R:I299	6.28	Yes	Yes	1	8	9
227	R:R:F230	R:R:Q451	8.2	Yes	Yes	1	8	9
228	R:R:F230	R:R:G452	3.01	Yes	No	0	8	9
229	R:R:F291	R:R:L232	12.18	No	No	0	5	8
230	R:R:L292	R:R:R233	7.29	No	Yes	1	6	8
231	R:R:N295	R:R:R233	13.26	Yes	Yes	1	8	8
232	R:R:R233	R:R:Y296	3.09	Yes	Yes	1	8	7
233	R:R:R233	R:R:Y421	3.09	Yes	Yes	1	8	8
234	R:R:A234	R:R:F238	2.77	No	No	1	8	7
235	R:R:F288	R:R:S236	3.96	Yes	No	0	7	7
236	R:R:F291	R:R:S236	9.25	No	No	0	5	7
237	R:R:F288	R:R:I237	3.77	Yes	No	0	7	7
238	R:R:D241	R:R:K240	4.15	No	Yes	0	8	7
239	R:R:K240	R:R:L244	4.23	Yes	Yes	1	7	5
240	R:R:F288	R:R:K240	16.13	Yes	Yes	1	7	7
241	R:R:A284	R:R:V243	5.09	No	No	0	6	5
242	R:R:L244	R:R:Y245	9.38	Yes	No	0	5	4
243	R:R:L244	R:R:V285	2.98	Yes	No	0	5	6
244	R:R:G277	R:R:R282	4.5	No	No	0	4	8
245	R:R:C281	R:R:C351	7.28	No	No	0	9	9
246	R:R:N348	R:R:R282	9.64	No	No	0	7	8
247	R:R:R282	R:R:W352	26.99	No	Yes	0	8	8
248	R:R:F287	R:R:V283	7.87	No	No	0	3	4
249	R:R:L289	R:R:V285	2.98	Yes	No	0	7	6
250	R:R:T286	R:R:V340	3.17	No	No	1	7	5
251	R:R:T286	R:R:W352	4.85	No	Yes	1	7	8
252	R:R:F288	R:R:L289	6.09	Yes	Yes	1	7	7
253	R:R:L289	R:R:W339	4.56	Yes	Yes	1	7	8
254	R:R:I363	R:R:L289	4.28	No	Yes	1	7	7
255	R:R:F291	R:R:Y290	7.22	No	Yes	0	5	9
256	R:R:T294	R:R:Y290	8.74	No	Yes	1	8	9
257	R:R:W329	R:R:Y290	3.86	Yes	Yes	1	9	9
258	R:R:P332	R:R:Y290	2.78	Yes	Yes	1	9	9
259	R:R:L292	R:R:Y296	5.86	No	Yes	1	6	7
260	R:R:A293	R:R:F335	2.77	No	Yes	0	6	5
261	R:R:T294	R:R:W329	6.06	No	Yes	1	8	9
262	R:R:P332	R:R:T294	3.5	Yes	No	1	9	8
263	R:R:I299	R:R:N295	7.08	Yes	Yes	1	9	8
264	R:R:I367	R:R:Y296	8.46	No	Yes	1	7	7
265	R:R:I371	R:R:Y296	4.84	Yes	Yes	1	7	7
266	R:R:Y296	R:R:Y421	14.89	Yes	Yes	1	7	8
267	R:R:F327	R:R:Y297	7.22	No	Yes	0	5	6
268	R:R:L331	R:R:Y297	7.03	No	Yes	0	4	6
269	R:R:P332	R:R:Y297	9.74	Yes	Yes	1	9	6
270	R:R:F335	R:R:Y297	9.28	Yes	Yes	1	5	6
271	R:R:V301	R:R:W298	3.68	No	Yes	0	8	9
272	R:R:T325	R:R:W298	4.85	No	Yes	0	5	9
273	R:R:W298	R:R:W329	20.62	Yes	Yes	1	9	9
274	R:R:I299	R:R:Q451	6.86	Yes	Yes	1	9	9
275	R:R:L300	R:R:L304	6.92	Yes	No	0	8	5
276	R:R:L300	R:R:S370	10.51	Yes	No	0	8	7
277	R:R:L300	R:R:L373	5.54	Yes	No	0	8	7
278	R:R:L300	R:R:N374	4.12	Yes	No	0	8	9
279	R:R:F324	R:R:V301	3.93	No	No	0	7	8
280	R:R:E302	R:R:L416	7.95	Yes	No	0	9	9
281	R:R:F417	R:R:G303	6.02	Yes	No	0	9	9
282	R:R:L304	R:R:L377	2.77	No	No	0	5	7
283	R:R:L309	R:R:Y305	16.41	No	Yes	0	8	8
284	R:R:F324	R:R:Y305	5.16	No	Yes	0	7	8
285	R:R:I310	R:R:L306	2.85	Yes	Yes	4	8	9
286	R:R:I381	R:R:L306	7.14	No	Yes	4	9	9
287	R:R:L306	R:R:L413	2.77	Yes	Yes	4	9	9
288	R:R:F417	R:R:L306	4.87	Yes	Yes	4	9	9
289	R:R:H307	R:R:M312	5.25	No	No	0	8	5
290	R:R:H307	R:R:L377	9	No	No	0	8	7
291	R:R:H307	R:R:N380	12.75	No	No	0	8	8
292	R:R:A313	R:R:S308	3.42	No	No	0	7	7
293	R:R:F311	R:R:I310	5.02	Yes	Yes	4	6	8
294	R:R:I310	R:R:I381	4.42	Yes	No	4	8	9
295	R:R:I310	R:R:V384	4.61	Yes	No	4	8	8
296	R:R:F311	R:R:M312	3.73	Yes	No	0	6	5
297	R:R:F311	R:R:N380	7.25	Yes	No	0	6	8
298	R:R:F311	R:R:V384	5.24	Yes	No	4	6	8
299	R:R:A313	R:R:S316	3.42	No	No	0	7	7
300	R:R:F314	R:R:F315	30.01	No	No	0	7	6
301	R:R:S316	R:R:Y320	6.36	No	No	0	7	4
302	R:R:E317	R:R:K318	6.75	No	No	0	6	5
303	R:R:E317	R:R:K319	14.85	No	No	0	6	6
304	R:R:E317	R:R:Y320	3.37	No	No	0	6	4
305	R:R:G323	R:R:W322	2.81	No	No	0	1	3
306	R:R:V326	R:R:W322	9.81	No	No	0	4	3
307	R:R:L331	R:R:V334	2.98	No	No	0	4	4
308	R:R:F335	R:R:P332	2.89	Yes	Yes	1	5	9
309	R:R:F335	R:R:I363	7.54	Yes	No	1	5	7
310	R:R:F335	R:R:P366	8.67	Yes	No	0	5	9
311	R:R:V340	R:R:W339	3.68	No	Yes	1	5	8
312	R:R:W339	R:R:W352	6.56	Yes	Yes	1	8	8
313	R:R:I362	R:R:W339	7.05	No	Yes	0	8	8
314	R:R:I363	R:R:W339	10.57	No	Yes	1	7	8
315	R:R:V340	R:R:W352	9.81	No	Yes	1	5	8
316	R:R:L346	R:R:V342	2.98	No	Yes	0	3	5
317	R:R:K359	R:R:V342	4.55	Yes	Yes	0	3	5
318	R:R:I362	R:R:V342	4.61	No	Yes	0	8	5
319	R:R:R343	R:R:T349	3.88	Yes	No	0	8	5
320	R:R:R343	R:R:W352	8	Yes	Yes	1	8	8
321	R:R:R343	R:R:S356	9.22	Yes	No	1	8	4
322	R:R:K359	R:R:R343	3.71	Yes	Yes	1	3	8
323	R:R:L346	R:R:T345	4.42	No	No	0	3	3
324	R:R:A347	R:R:S356	3.42	No	No	0	7	4
325	R:R:C351	R:R:D353	4.67	No	No	0	9	5
326	R:R:D353	R:R:L354	6.79	No	No	0	5	5
327	R:R:K359	R:R:S356	7.65	Yes	No	1	3	4
328	R:R:K360	R:R:W361	8.12	No	Yes	1	7	8
329	R:R:K360	R:R:Y429	17.91	No	Yes	1	7	6
330	R:R:Q364	R:R:W361	10.95	Yes	Yes	1	7	8
331	R:R:W361	R:R:Y429	3.86	Yes	Yes	1	8	6
332	R:R:Q364	R:R:Y429	10.15	Yes	Yes	1	7	6
333	R:R:P366	R:R:V365	3.53	No	No	0	9	5
334	R:R:I367	R:R:I371	2.94	No	Yes	1	7	7
335	R:R:L368	R:R:M425	4.24	No	Yes	0	4	6
336	R:R:I371	R:R:Y421	4.84	Yes	Yes	1	7	8
337	R:R:M425	R:R:V372	4.56	Yes	No	0	6	4
338	R:R:F417	R:R:N374	12.08	Yes	No	0	9	9
339	R:R:F375	R:R:I379	8.79	No	No	0	7	5
340	R:R:F375	R:R:I422	23.86	No	No	0	7	5
341	R:R:F378	R:R:V382	7.87	Yes	No	0	9	7
342	R:R:F378	R:R:L413	7.31	Yes	Yes	4	9	9
343	R:R:F378	R:R:F417	12.86	Yes	Yes	4	9	9
344	R:R:F378	R:R:V419	9.18	Yes	No	0	9	7
345	R:R:N380	R:R:R383	6.03	No	No	0	8	8
346	R:R:I381	R:R:L413	2.85	No	Yes	4	9	9
347	R:R:T410	R:R:V382	4.76	No	No	0	9	7
348	R:R:K388	R:R:V384	4.55	No	No	0	9	8
349	R:R:A386	R:R:L406	3.15	No	No	0	6	8
350	R:R:L389	R:R:Q402	6.65	No	No	0	8	6
351	R:R:K405	R:R:L389	2.82	No	No	0	8	8
352	R:R:L389	R:R:L406	2.77	No	No	0	8	8
353	R:R:Q402	R:R:T399	2.83	No	No	0	6	6
354	R:R:Q401	R:R:R404	10.51	No	No	0	6	6
355	R:R:K405	R:R:K408	4.31	No	No	0	8	8
356	R:R:K405	R:R:S409	4.59	No	No	0	8	9
357	R:R:L406	R:R:T410	2.95	No	No	0	8	9
358	R:R:L407	R:R:L411	5.54	No	No	0	8	8
359	R:R:K408	R:R:V412	3.04	No	No	0	8	8
360	R:R:F417	R:R:L413	8.53	Yes	Yes	4	9	9
361	R:R:M414	R:R:P415	3.35	No	No	0	8	9
362	R:R:M414	R:R:V419	4.56	No	No	0	8	7
363	R:R:I458	R:R:P415	5.08	No	No	0	8	9
364	R:R:F417	R:R:L416	6.09	Yes	No	0	9	9
365	R:R:L416	R:R:Y459	12.89	No	Yes	0	9	8
366	R:R:G418	R:R:H420	3.18	No	Yes	1	9	8
367	R:R:G418	R:R:Y421	2.9	No	Yes	1	9	8
368	R:R:H420	R:R:Y421	23.96	Yes	Yes	1	8	8
369	R:R:H420	R:R:Y443	3.27	Yes	Yes	1	8	4
370	R:R:F447	R:R:H420	6.79	No	Yes	1	5	8
371	R:R:H420	R:R:N448	8.93	Yes	No	1	8	6
372	R:R:H420	R:R:Q451	11.13	Yes	Yes	1	8	9
373	R:R:N448	R:R:Y421	16.28	No	Yes	1	6	8
374	R:R:Q451	R:R:Y421	9.02	Yes	Yes	1	9	8
375	R:R:F424	R:R:V423	9.18	Yes	No	1	7	6
376	R:R:V423	R:R:Y443	7.57	No	Yes	1	6	4
377	R:R:F424	R:R:T427	7.78	Yes	No	1	7	5
378	R:R:F424	R:R:Q440	17.57	Yes	No	1	7	6
379	R:R:F424	R:R:Y443	7.22	Yes	Yes	1	7	4
380	R:R:E444	R:R:F424	3.5	Yes	Yes	1	7	7
381	R:R:A426	R:R:M425	3.22	No	Yes	0	5	6
382	R:R:P428	R:R:T427	3.5	No	No	0	7	5
383	R:R:Q440	R:R:T427	12.76	No	No	1	6	5
384	R:R:L436	R:R:T430	2.95	No	No	0	4	5
385	R:R:T430	R:R:W437	3.64	No	Yes	0	5	5
386	R:R:V432	R:R:W437	9.81	No	Yes	1	5	5
387	R:R:Q438	R:R:W437	3.29	No	Yes	0	4	5
388	R:R:M441	R:R:W437	15.12	Yes	Yes	1	6	5
389	R:R:E444	R:R:Y443	3.37	Yes	Yes	1	7	4
390	R:R:F447	R:R:Y443	16.5	No	Yes	1	5	4
391	R:R:E444	R:R:N448	13.15	Yes	No	1	7	6
392	R:R:F450	R:R:L446	3.65	No	No	0	7	5
393	R:R:F450	R:R:F454	7.5	No	No	0	7	6
394	R:R:F453	R:R:I457	11.3	No	No	0	6	6
395	R:R:F461	R:R:I457	3.77	No	No	0	8	6
396	R:R:I458	R:R:Y459	8.46	No	Yes	0	8	8
397	R:R:C460	R:R:V466	3.42	No	Yes	0	9	9
398	R:R:E465	R:R:N463	5.26	No	No	0	9	9
399	R:R:N463	R:R:V466	5.91	No	Yes	0	9	9
400	R:R:I470	R:R:V466	3.07	No	Yes	0	5	9
401	R:R:T478	R:R:W474	12.13	No	No	0	4	5
402	R:R:L481	R:R:W477	3.42	No	No	0	4	4
403	L:L:E22	L:L:K26	2.7	No	No	0	0	0
404	R:R:A144	R:R:Y167	2.67	No	Yes	0	7	5
405	R:R:A333	R:R:Y290	2.67	No	Yes	0	5	9
406	R:R:R476	R:R:S475	2.64	No	No	0	7	4
407	R:R:F461	R:R:V204	2.62	No	No	0	8	5
408	R:R:F335	R:R:V336	2.62	Yes	No	0	5	7
409	R:R:F375	R:R:V419	2.62	No	No	0	7	7
410	R:R:R179	R:R:T178	2.59	No	No	0	3	3
411	R:R:F287	R:R:T286	2.59	No	No	0	3	7
412	R:R:V455	R:R:Y459	2.52	No	Yes	0	9	8
413	R:R:F212	R:R:I208	2.51	Yes	No	0	7	8
414	R:R:F447	R:R:L446	2.44	No	No	0	5	5
415	R:R:M224	R:R:Y221	2.39	No	No	0	5	7
416	L:L:E22	L:L:R25	2.33	No	Yes	0	0	0
417	R:R:E36	R:R:F39	2.33	No	No	0	6	7
418	R:R:N358	R:R:W361	2.26	No	Yes	0	4	8
419	R:R:G277	R:R:G350	2.11	No	No	0	4	5
420	R:R:G330	R:R:P332	2.03	No	Yes	0	7	9
421	R:R:P110	R:R:P119	1.95	No	No	0	6	6
422	R:R:A279	R:R:G280	1.95	No	No	0	4	4
423	R:R:A122	R:R:P123	1.87	No	No	0	1	7
424	R:R:G194	R:R:S449	1.86	No	No	0	9	9
425	R:R:G194	R:R:V193	1.84	No	No	0	9	6
426	R:R:G280	R:R:V283	1.84	No	No	0	4	4
427	R:R:G328	R:R:V301	1.84	No	No	0	9	8
428	R:R:G357	R:R:K359	1.74	No	Yes	0	6	3
429	L:L:G12	R:R:L354	1.71	No	No	0	0	5
430	R:R:A284	R:R:V239	1.7	No	No	0	6	5
431	R:R:G464	R:R:N463	1.7	No	No	0	7	9
432	R:R:L120	R:R:P119	1.64	No	No	0	4	6
433	R:R:L156	R:R:P158	1.64	No	No	0	4	4
434	R:R:C462	R:R:I457	1.64	No	No	0	6	6
435	R:R:G464	R:R:Q467	1.64	No	No	0	7	8
436	R:R:S196	R:R:V193	1.62	No	No	0	7	6
437	R:R:S196	R:R:V197	1.62	No	No	0	7	5
438	R:R:S341	R:R:V342	1.62	No	Yes	0	5	5
439	R:R:V235	R:R:V239	1.6	No	No	0	4	5
440	R:R:S475	R:R:T478	1.6	No	No	0	4	4
441	R:R:G159	R:R:H160	1.59	No	No	0	3	4
442	R:R:A344	R:R:N348	1.56	No	No	0	4	7
443	R:R:I362	R:R:V338	1.54	No	No	0	8	5
444	L:L:M18	L:L:S17	1.53	No	No	0	0	0
445	R:R:C117	R:R:Q47	1.53	No	No	0	9	6
446	R:R:K172	R:R:S168	1.53	No	No	0	3	6
447	R:R:C131	R:R:E169	1.52	No	Yes	2	9	5
448	R:R:C170	R:R:E169	1.52	No	Yes	2	9	5
449	R:R:L385	R:R:S409	1.5	No	No	0	8	9
450	R:R:L436	R:R:V439	1.49	No	No	0	4	5
451	R:R:L321	R:R:T218	1.47	No	Yes	0	6	7
452	R:R:L479	R:R:T478	1.47	No	No	0	4	4
453	R:R:I190	R:R:M189	1.46	No	No	0	6	4
454	R:R:I371	R:R:M425	1.46	Yes	Yes	0	7	6
455	R:R:Q401	R:R:T399	1.42	No	No	0	6	6
456	R:R:E177	R:R:T178	1.41	No	No	0	1	3
457	R:R:E391	R:R:T387	1.41	No	No	0	7	7
458	R:R:E431	R:R:T430	1.41	No	No	0	3	5
459	R:R:A165	R:R:R146	1.38	No	Yes	0	7	8
460	R:R:E391	R:R:K388	1.35	No	No	0	7	9
461	R:R:A188	R:R:Y191	1.33	No	Yes	0	5	7
462	R:R:D185	R:R:E182	1.3	No	No	0	2	2
463	R:R:R162	R:R:T163	1.29	No	No	0	3	5
464	R:R:R390	R:R:T387	1.29	No	No	0	6	7
465	R:R:R400	R:R:T399	1.29	No	No	0	8	6
466	R:R:H140	R:R:N139	1.28	No	No	0	3	4
467	L:L:H32	L:L:Q29	1.24	No	No	0	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:E4	5.5925	4	1	0
2	L:L:I5	5.5	4	1	0
3	L:L:Q6	6.684	5	1	0
4	L:L:M8	3.4	4	1	0
5	L:L:H14	8.095	4	8	0
6	L:L:R20	8.1425	4	7	0
7	L:L:W23	5.746	5	6	0
8	L:L:L24	8.8275	4	0	0
9	L:L:R25	3.4525	4	0	0
10	R:R:V31	6.06	4	7	6
11	R:R:K34	3.985	4	6	4
12	R:R:Q37	6.5025	4	0	7
13	R:R:C108	4.9575	4	3	9
14	R:R:I115	5.074	5	2	5
15	R:R:L116	6.0975	4	2	5
16	R:R:E125	4.7675	4	3	5
17	R:R:V127	5.2325	4	3	7
18	R:R:P132	5.16	7	2	9
19	R:R:Y134	5.1	7	2	5
20	R:R:I135	4.81	6	2	7
21	R:R:F138	6.60571	7	2	4
22	R:R:Y145	5.1825	4	5	4
23	R:R:R146	5.49	5	3	8
24	R:R:R147	4.47	4	5	3
25	R:R:C148	4.0225	4	3	9
26	R:R:W154	5.2725	4	3	9
27	R:R:E155	8.6025	4	5	4
28	R:R:W164	5.4575	4	5	5
29	R:R:Y167	4.7225	4	2	5
30	R:R:E169	3	4	2	5
31	R:R:V171	3.515	4	2	3
32	R:R:L187	3.83	4	0	5
33	R:R:Y191	5.054	5	0	7
34	R:R:Y195	6.25429	7	1	7
35	R:R:F212	5.12	5	0	7
36	R:R:T218	4.21	4	0	7
37	R:R:L226	5.985	4	1	9
38	R:R:F230	8.584	5	1	8
39	R:R:M231	3.985	4	0	8
40	R:R:R233	7.11667	6	1	8
41	R:R:K240	6.8475	4	1	7
42	R:R:L244	4.855	4	1	5
43	R:R:F288	6.736	5	1	7
44	R:R:L289	4.438	5	1	7
45	R:R:Y290	5.054	5	1	9
46	R:R:N295	11.4775	4	1	8
47	R:R:Y296	7.428	5	1	7
48	R:R:Y297	8.3175	4	1	6
49	R:R:W298	11.58	5	1	9
50	R:R:I299	5.7675	4	1	9
51	R:R:L300	6.7725	4	0	8
52	R:R:E302	8.17	4	0	9
53	R:R:Y305	9.38	4	0	8
54	R:R:L306	4.4075	4	4	9
55	R:R:I310	4.225	4	4	8
56	R:R:F311	5.31	4	4	6
57	R:R:W329	8.4275	4	1	9
58	R:R:P332	4.188	5	1	9
59	R:R:F335	5.62833	6	1	5
60	R:R:W339	6.484	5	1	8
61	R:R:V342	3.44	4	0	5
62	R:R:R343	6.2025	4	1	8
63	R:R:W352	11.242	5	1	8
64	R:R:K359	4.4125	4	1	3
65	R:R:W361	6.2975	4	1	8
66	R:R:Q364	8.095	4	1	7
67	R:R:I371	3.52	4	1	7
68	R:R:F378	9.305	4	4	9
69	R:R:L413	5.365	4	4	9
70	R:R:F417	8.40833	6	4	9
71	R:R:H420	9.54333	6	1	8
72	R:R:Y421	10.7114	7	1	8
73	R:R:F424	9.05	5	1	7
74	R:R:M425	3.37	4	0	6
75	R:R:Y429	9.736	5	1	6
76	R:R:W437	6.72429	7	1	5
77	R:R:M441	7.9525	4	1	6
78	R:R:Y443	7.586	5	1	4
79	R:R:E444	7.88	4	1	7
80	R:R:M445	5.19667	6	1	6
81	R:R:Q451	8.8025	4	1	9
82	R:R:Y459	7.3275	4	0	8
83	R:R:V466	4.2175	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:E4	R:R:M445	79.6118	8.12	Yes	Yes	1	0	6
2	L:L:L7	R:R:M445	83.9925	5.65	No	Yes	0	0	6
3	L:L:I5	R:R:L292	12.0653	2.85	Yes	No	1	0	6
4	R:R:L292	R:R:R233	11.0186	7.29	No	Yes	1	6	8
5	L:L:E4	R:R:R233	74.0428	4.65	Yes	Yes	1	0	8
6	L:L:I5	R:R:L289	10.0618	4.28	Yes	Yes	1	0	7
7	R:R:L244	R:R:Y245	15.2847	9.38	Yes	No	0	5	4
8	L:L:L11	R:R:Y245	14.8394	14.07	No	No	0	0	4
9	L:L:L11	R:R:F184	78.1252	8.53	No	No	0	0	6
10	L:L:L11	L:L:L15	91.9871	4.15	No	No	0	0	0
11	L:L:M18	L:L:S17	99.2772	1.53	No	No	0	0	0
12	L:L:H14	L:L:M18	100	13.13	Yes	No	0	0	0
13	L:L:R20	L:L:S17	94.4751	3.95	Yes	No	7	0	0
14	L:L:L24	R:R:D137	10.4103	14.93	Yes	No	0	0	5
15	L:L:R20	R:R:D137	92.727	13.1	Yes	No	0	0	5
16	R:R:D137	R:R:I135	82.1807	2.8	No	Yes	0	5	7
17	R:R:D113	R:R:W118	25.2822	5.58	No	No	0	9	9
18	R:R:L116	R:R:W118	69.6676	9.11	Yes	No	0	5	9
19	R:R:I115	R:R:L116	22.9344	2.85	Yes	Yes	2	5	5
20	R:R:I115	R:R:I135	23.92	2.94	Yes	Yes	2	5	7
21	R:R:L116	R:R:P132	24.1448	6.57	Yes	Yes	2	5	9
22	R:R:I135	R:R:P132	27.181	5.08	Yes	Yes	2	7	9
23	R:R:L116	R:R:Y134	23.6915	5.86	Yes	Yes	2	5	5
24	R:R:I135	R:R:Y134	26.2157	6.04	Yes	Yes	2	7	5
25	R:R:V129	R:R:W118	43.5848	4.9	No	No	0	5	9
26	R:R:V127	R:R:V129	41.3381	3.21	Yes	No	0	7	5
27	R:R:E125	R:R:V127	27.8768	4.28	Yes	Yes	3	5	7
28	R:R:A122	R:R:E125	24.5931	7.54	No	Yes	0	1	5
29	R:R:A122	R:R:P123	23.4343	1.87	No	No	0	1	7
30	R:R:G105	R:R:P123	22.2742	4.06	No	No	0	5	7
31	R:R:G105	R:R:R106	21.1128	3	No	No	0	5	1
32	R:R:N151	R:R:R106	18.7865	10.85	No	No	0	5	1
33	R:R:D113	R:R:E111	16.2182	15.59	No	No	0	9	7
34	R:R:N151	R:R:S153	17.6215	4.47	No	No	0	5	4
35	R:R:R150	R:R:S153	16.4552	5.27	No	No	0	1	4
36	R:R:D149	R:R:R150	15.2878	13.1	No	No	0	5	1
37	R:R:D149	R:R:E155	14.1191	15.59	No	Yes	0	5	4
38	R:R:S449	R:R:Y195	13.5519	5.09	No	Yes	0	9	7
39	R:R:G194	R:R:S449	12.9008	1.86	No	No	0	9	9
40	R:R:G194	R:R:V193	12.2589	1.84	No	No	0	9	6
41	R:R:S196	R:R:V193	11.6439	1.62	No	No	0	7	6
42	R:R:S196	R:R:V197	11.0326	1.62	No	No	0	7	5
43	R:R:F453	R:R:V197	10.4232	9.18	No	No	0	6	5
44	R:R:N295	R:R:R233	86.4971	13.26	Yes	Yes	1	8	8
45	R:R:F230	R:R:N295	27.8321	18.12	Yes	Yes	1	8	8
46	R:R:N295	R:R:S229	32.0089	7.45	Yes	No	0	8	9
47	R:R:L226	R:R:S229	29.715	4.5	Yes	No	0	9	9
48	R:R:E302	R:R:L226	86.69	9.28	Yes	Yes	0	9	9
49	R:R:E302	R:R:H223	35.1217	8.62	Yes	No	0	9	9
50	R:R:H223	R:R:R219	32.5834	11.28	No	No	0	9	9
51	R:R:N220	R:R:R219	18.1348	6.03	No	No	0	9	9
52	R:R:L215	R:R:N220	17.2534	5.49	No	No	0	9	9
53	R:R:L215	R:R:V466	10.1702	4.47	No	Yes	0	9	9
54	R:R:C460	R:R:V466	16.7615	3.42	No	Yes	0	9	9
55	R:R:F230	R:R:L226	29.2979	7.31	Yes	Yes	1	8	9
56	R:R:I299	R:R:N295	27.2515	7.08	Yes	Yes	1	9	8
57	R:R:I299	R:R:L226	29.0761	2.85	Yes	Yes	1	9	9
58	R:R:E465	R:R:R219	13.604	5.82	No	No	0	9	9
59	R:R:E465	R:R:N463	12.7232	5.26	No	No	0	9	9
60	R:R:N463	R:R:V466	10.0955	5.91	No	Yes	0	9	9
61	R:R:E302	R:R:I222	10.9371	6.83	Yes	No	0	9	9
62	R:R:I222	R:R:Y305	10.0398	8.46	No	Yes	0	9	8
63	R:R:T218	R:R:Y305	11.1901	7.49	Yes	Yes	0	7	8
64	R:R:E302	R:R:L416	46.6768	7.95	Yes	No	0	9	9
65	R:R:L289	R:R:W339	14.9742	4.56	Yes	Yes	1	7	8
66	R:R:F417	R:R:L416	43.7202	6.09	Yes	No	0	9	9
67	R:R:F417	R:R:L306	13.5599	4.87	Yes	Yes	4	9	9
68	R:R:I310	R:R:L306	11.8099	2.85	Yes	Yes	4	8	9
69	R:R:F378	R:R:F417	20.1922	12.86	Yes	Yes	4	9	9
70	R:R:F378	R:R:V382	14.81	7.87	Yes	No	0	9	7
71	R:R:T410	R:R:V382	13.8312	4.76	No	No	0	9	7
72	R:R:L406	R:R:T410	12.8512	2.95	No	No	0	8	9
73	R:R:L389	R:R:L406	10.8875	2.77	No	No	0	8	8
74	L:L:H14	L:L:L15	90.8006	3.86	Yes	No	8	0	0
75	L:L:L7	R:R:F184	80.3407	3.65	No	No	0	0	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:V2	R:R:Q364	7.16	1	No	Yes	0	7	0	1
L:L:V2	R:R:I367	4.61	1	No	No	0	7	0	1
L:L:S3	R:R:E444	11.5	1	No	Yes	0	7	0	1
L:L:S3	R:R:M445	3.07	1	No	Yes	0	6	0	1
L:L:E4	R:R:Y195	6.73	1	Yes	Yes	0	7	0	1
L:L:E4	R:R:R233	4.65	1	Yes	Yes	0	8	0	1
L:L:E4	R:R:M445	8.12	1	Yes	Yes	0	6	0	1
L:L:I5	R:R:L289	4.28	1	Yes	Yes	0	7	0	1
L:L:I5	R:R:L292	2.85	1	Yes	No	0	6	0	1
L:L:I5	R:R:Q364	4.12	1	Yes	Yes	0	7	0	1
L:L:Q6	R:R:Y429	12.4	1	Yes	Yes	0	6	0	1
L:L:Q6	R:R:W437	3.29	1	Yes	Yes	0	5	0	1
L:L:Q6	R:R:M441	6.8	1	Yes	Yes	0	6	0	1
L:L:L7	R:R:F184	3.65	0	No	No	0	6	0	1
L:L:L7	R:R:M441	5.65	0	No	Yes	0	6	0	1
L:L:L7	R:R:M445	5.65	0	No	Yes	0	6	0	1
L:L:M8	R:R:K240	2.88	1	Yes	Yes	0	7	0	1
L:L:M8	R:R:L244	2.83	1	Yes	Yes	0	5	0	1
L:L:M8	R:R:F288	3.73	1	Yes	Yes	0	7	0	1
L:L:M8	R:R:D353	4.16	1	Yes	No	0	5	0	1
L:L:H9	R:R:S355	8.37	1	No	No	0	7	0	1
L:L:H9	R:R:K360	3.93	1	No	No	0	7	0	1
L:L:H9	R:R:Y429	4.36	1	No	Yes	0	6	0	1
L:L:N10	R:R:V432	4.43	1	No	No	0	5	0	1
L:L:N10	R:R:W437	7.91	1	No	Yes	0	5	0	1
L:L:L11	R:R:F184	8.53	0	No	No	0	6	0	1
L:L:L11	R:R:Y245	14.07	0	No	No	0	4	0	1
L:L:K13	R:R:V31	9.11	0	No	Yes	0	6	0	1
L:L:H14	R:R:E180	8.62	8	Yes	No	0	3	0	1
L:L:H14	R:R:R181	6.77	8	Yes	No	0	3	0	1
L:L:L15	R:R:R181	3.64	8	No	No	0	3	0	1
L:L:N16	R:R:T33	7.31	6	No	No	0	7	0	1
L:L:N16	R:R:E35	5.26	6	No	No	0	5	0	1
L:L:S17	R:R:V31	4.85	7	No	Yes	0	6	0	1
L:L:M18	R:R:E177	5.41	0	No	No	0	1	0	1
L:L:E19	R:R:K34	4.05	0	No	Yes	0	4	0	1
L:L:R20	R:R:V31	5.23	7	Yes	Yes	0	6	0	1
L:L:R20	R:R:Y136	10.29	7	Yes	No	0	4	0	1
L:L:R20	R:R:D137	13.1	7	Yes	No	0	5	0	1
L:L:W23	R:R:K34	3.48	6	Yes	Yes	0	4	0	1
L:L:W23	R:R:Q37	4.38	6	Yes	Yes	0	7	0	1
L:L:W23	R:R:I38	5.87	6	Yes	No	0	7	0	1
L:L:L24	R:R:D137	14.93	0	Yes	No	0	5	0	1
L:L:L24	R:R:F138	12.18	0	Yes	Yes	0	4	0	1
L:L:R25	R:R:V171	3.92	0	Yes	Yes	0	3	0	1
L:L:L28	R:R:F138	7.31	2	No	Yes	0	4	0	1
L:L:L28	R:R:V171	2.98	2	No	Yes	0	3	0	1
L:L:D30	R:R:H114	6.3	9	No	No	0	4	0	1
L:L:V31	R:R:D113	4.38	0	No	No	0	9	0	1
L:L:V31	R:R:H114	4.15	0	No	No	0	4	0	1
L:L:F34	R:R:H114	5.66	9	No	No	0	4	0	1
R:R:V31	R:R:Y136	5.05	7	Yes	No	6	4	1	1
R:R:E36	R:R:M32	10.83	0	No	No	6	6	2	2
R:R:M32	R:R:Q37	4.08	0	No	Yes	6	7	2	1
R:R:M32	R:R:Y136	5.99	0	No	No	6	4	2	1
R:R:E35	R:R:T33	12.7	6	No	No	5	7	1	1
R:R:E36	R:R:T33	15.52	0	No	No	6	7	2	1
R:R:E35	R:R:K34	4.05	6	No	Yes	5	4	1	1
R:R:I38	R:R:K34	4.36	6	No	Yes	7	4	1	1
R:R:L40	R:R:Q37	9.32	0	No	Yes	5	7	2	1
R:R:I135	R:R:Q37	8.23	2	Yes	Yes	7	7	2	1
R:R:D113	R:R:E111	15.59	0	No	No	9	7	1	2
R:R:D113	R:R:W118	5.58	0	No	No	9	9	1	2
R:R:I135	R:R:P132	5.08	2	Yes	Yes	7	9	2	2
R:R:F138	R:R:P132	8.67	2	Yes	Yes	4	9	1	2
R:R:P132	R:R:Y167	2.78	2	Yes	Yes	9	5	2	2
R:R:D137	R:R:I135	2.8	0	No	Yes	5	7	1	2
R:R:F138	R:R:I135	3.77	2	Yes	Yes	4	7	1	2
R:R:F138	R:R:Y167	6.19	2	Yes	Yes	4	5	1	2
R:R:C170	R:R:F138	4.19	2	No	Yes	9	4	2	1
R:R:F138	R:R:V171	3.93	2	Yes	Yes	4	3	1	1
R:R:S168	R:R:V171	3.23	0	No	Yes	6	3	2	1
R:R:E180	R:R:V432	5.7	0	No	No	3	5	1	1
R:R:D185	R:R:R181	9.53	0	No	No	2	3	2	1
R:R:F184	R:R:W437	4.01	0	No	Yes	6	5	1	1
R:R:L187	R:R:M441	4.24	0	Yes	Yes	5	6	2	1
R:R:L187	R:R:M445	4.24	0	Yes	Yes	5	6	2	1
R:R:I190	R:R:M445	2.92	0	No	Yes	6	6	2	1
R:R:Y191	R:R:Y195	4.96	0	Yes	Yes	7	7	2	1
R:R:D241	R:R:Y191	8.05	0	No	Yes	8	7	2	2
R:R:M445	R:R:Y191	7.18	1	Yes	Yes	6	7	1	2
R:R:R233	R:R:Y195	11.32	1	Yes	Yes	8	7	1	1
R:R:A234	R:R:Y195	5.34	1	No	Yes	8	7	2	1
R:R:I237	R:R:Y195	7.25	0	No	Yes	7	7	2	1
R:R:F238	R:R:Y195	3.09	1	No	Yes	7	7	2	1
R:R:S449	R:R:Y195	5.09	0	No	Yes	9	7	2	1
R:R:L292	R:R:R233	7.29	1	No	Yes	6	8	1	1
R:R:N295	R:R:R233	13.26	1	Yes	Yes	8	8	2	1
R:R:R233	R:R:Y296	3.09	1	Yes	Yes	8	7	1	2
R:R:R233	R:R:Y421	3.09	1	Yes	Yes	8	8	1	2
R:R:A234	R:R:F238	2.77	1	No	No	8	7	2	2
R:R:F288	R:R:S236	3.96	1	Yes	No	7	7	1	2
R:R:F288	R:R:I237	3.77	1	Yes	No	7	7	1	2
R:R:D241	R:R:K240	4.15	0	No	Yes	8	7	2	1
R:R:K240	R:R:L244	4.23	1	Yes	Yes	7	5	1	1
R:R:F288	R:R:K240	16.13	1	Yes	Yes	7	7	1	1
R:R:L244	R:R:Y245	9.38	1	Yes	No	5	4	1	1
R:R:L244	R:R:V285	2.98	1	Yes	No	5	6	1	2
R:R:L289	R:R:V285	2.98	1	Yes	No	7	6	1	2
R:R:F288	R:R:L289	6.09	1	Yes	Yes	7	7	1	1
R:R:L289	R:R:W339	4.56	1	Yes	Yes	7	8	1	2
R:R:I363	R:R:L289	4.28	1	No	Yes	7	7	2	1
R:R:L292	R:R:Y296	5.86	1	No	Yes	6	7	1	2
R:R:I367	R:R:Y296	8.46	1	No	Yes	7	7	1	2
R:R:I371	R:R:Y296	4.84	1	Yes	Yes	7	7	2	2
R:R:Y296	R:R:Y421	14.89	1	Yes	Yes	7	8	2	2
R:R:I363	R:R:W339	10.57	1	No	Yes	7	8	2	2
R:R:C351	R:R:D353	4.67	0	No	No	9	5	2	1
R:R:D353	R:R:L354	6.79	0	No	No	5	5	1	1
R:R:K360	R:R:W361	8.12	1	No	Yes	7	8	1	2
R:R:K360	R:R:Y429	17.91	1	No	Yes	7	6	1	1
R:R:Q364	R:R:W361	10.95	1	Yes	Yes	7	8	1	2
R:R:W361	R:R:Y429	3.86	1	Yes	Yes	8	6	2	1
R:R:Q364	R:R:Y429	10.15	1	Yes	Yes	7	6	1	1
R:R:I367	R:R:I371	2.94	1	No	Yes	7	7	1	2
R:R:I371	R:R:Y421	4.84	1	Yes	Yes	7	8	2	2
R:R:N448	R:R:Y421	16.28	1	No	Yes	6	8	2	2
R:R:F424	R:R:Y443	7.22	1	Yes	Yes	7	4	2	2
R:R:E444	R:R:F424	3.5	1	Yes	Yes	7	7	1	2
R:R:T430	R:R:W437	3.64	0	No	Yes	5	5	2	1
R:R:V432	R:R:W437	9.81	1	No	Yes	5	5	1	1
R:R:Q438	R:R:W437	3.29	0	No	Yes	4	5	2	1
R:R:M441	R:R:W437	15.12	1	Yes	Yes	6	5	1	1
R:R:E444	R:R:Y443	3.37	1	Yes	Yes	7	4	1	2
R:R:E444	R:R:N448	13.15	1	Yes	No	7	6	1	2
L:L:G12	R:R:L354	1.71	0	No	No	0	5	0	1
R:R:E177	R:R:T178	1.41	0	No	No	1	3	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8HA0_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.77
Number of Linked Nodes	373
Number of Links	467
Number of Hubs	83
Number of Links mediated by Hubs	282
Number of Communities	9
Number of Nodes involved in Communities	111
Number of Links involved in Communities	170

Path Summary
Number Of Nodes in MetaPath	76
Number Of Links MetaPath	75
Number of Shortest Paths	271048
Length Of Smallest Path	3
Average Path Length	21.2948
Length of Longest Path	46
Minimum Path Strength	1.35
Average Path Strength	6.54054
Maximum Path Strength	19.425
Minimum Path Correlation	0.7
Average Path Correlation	0.964151
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	60.5005
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.04
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q03431
Sequence	>8HA0_nogp_Chain_R V M T K E E Q I F L L H R A Q A Q C E K G R P C L P E W D H I L C W P L G A P G E V V A V P C P D Y I Y D F N H K G H A Y R R C D R N G S W E L V P G H N R T W A N Y S E C V K E T R E R E V F D R L A M I Y T V G Y S V S L A S L T V A V L I L A Y F R R L H C T R N Y I H M H L F L S F M L R A V S I F V K D A V L Y S A G Y A G C R V A V T F F L Y F L A T N Y Y W I L V E G L Y L H S L I F M A F F S E K K Y L W G F T V F G W G L P A V F V A V W V S V R A T L A N T G C W D L S S G N K K W I I Q V P I L A S I V L N F I L F I N I V R V L A T K L R E T N T R Q Q Y R K L L K S T L V L M P L F G V H Y I V F M A T P Y T E V S G T L W Q V Q M H Y E M L F N S F Q G F F V A I I Y C F C N G E V Q A E I K K S W S R W T L A L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9JR3	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-10-16	To be published
	9JR3 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2024-10-16	To be published
	9JR2	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-10-16	To be published
	9JR2 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2024-10-16	To be published
	8JR9	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371	chim(NtGi1-Gs)/β1/γ2	2.57	2023-08-02	10.1038/s41586-023-06467-w
	8JR9 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371		2.57	2023-08-02	10.1038/s41586-023-06467-w
	7Y36	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Teriparatide	-	Gs/β1/γ2	2.8	2023-07-05	To be published
	7Y36 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Teriparatide	-		2.8	2023-07-05	To be published
	7Y35	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/β1/γ2	2.9	2023-07-05	To be published
	7Y35 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-		2.9	2023-07-05	To be published
	8GW8	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	KHF	Gs/β1/γ2	2.9	2023-06-14	10.1038/s41586-023-06169-3
	8GW8 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	KHF		2.9	2023-06-14	10.1038/s41586-023-06169-3
	8FLU	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-	Gs/β1/γ2	2.76	2023-04-26	10.1016/j.str.2023.04.002
	8FLU (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-		2.76	2023-04-26	10.1016/j.str.2023.04.002
	8FLT	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	M-PTH(1-14)	-	Gs/β1/γ2	3.03	2023-04-26	10.1016/j.str.2023.04.002
	8FLT (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	M-PTH(1-14)	-		3.03	2023-04-26	10.1016/j.str.2023.04.002
	8FLS	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/β1/γ2	3.09	2023-04-26	10.1016/j.str.2023.04.002
	8FLS (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-		3.09	2023-04-26	10.1016/j.str.2023.04.002
	8FLR	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/β1/γ2	2.94	2023-04-26	10.1016/j.str.2023.04.002
	8FLR (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		2.94	2023-04-26	10.1016/j.str.2023.04.002
	8FLQ	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.55	2023-04-26	10.1016/j.str.2023.04.002
	8FLQ (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.55	2023-04-26	10.1016/j.str.2023.04.002
	8HAO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/β1/γ2	3.76	2022-12-21	10.1038/s41401-022-01032-z
	8HAO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.76	2022-12-21	10.1038/s41401-022-01032-z
	8HAF	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	chim(NtGi1-Gs)/β1/γ2	3.25	2022-12-21	10.1038/s41401-022-01032-z
	8HAF (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		3.25	2022-12-21	10.1038/s41401-022-01032-z
	8HA0	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/β1/γ2	2.62	2022-12-21	10.1038/s41401-022-01032-z
	8HA0 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.62	2022-12-21	10.1038/s41401-022-01032-z
	7VVO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	4.1	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		4.1	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVN	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.8	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVN (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.8	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVM	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.2	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVM (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.2	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVL	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.8	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVL (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVK	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.3	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVK (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.3	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVJ	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/β1/γ2	3.2	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVJ (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		3.2	2022-08-03	10.1016/j.molcel.2022.07.003
	6NBI	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	4	2019-04-17	10.1126/science.aav7942
	6NBI (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		4	2019-04-17	10.1126/science.aav7942
	6NBH	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	3.5	2019-04-17	10.1126/science.aav7942
	6NBH (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		3.5	2019-04-17	10.1126/science.aav7942
	6NBF	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	3	2019-04-17	10.1126/science.aav7942
	6NBF (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		3	2019-04-17	10.1126/science.aav7942
	6FJ3	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	-	2.5	2018-11-21	10.1038/s41594-018-0151-4

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