psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:S1	R:R:Q364	4.33	No	No	0	0	7
2	L:L:V2	R:R:L292	4.47	Yes	Yes	1	0	6
3	L:L:V2	R:R:Y296	5.05	Yes	Yes	1	0	7
4	L:L:V2	R:R:Y421	10.09	Yes	Yes	1	0	8
5	L:L:S3	R:R:Y191	3.82	No	Yes	0	0	7
6	L:L:S3	R:R:E444	8.62	No	Yes	0	0	7
7	L:L:E4	R:R:Y195	4.49	No	Yes	0	0	7
8	L:L:E4	R:R:I237	12.3	No	No	0	0	7
9	L:L:E4	R:R:L292	7.95	No	Yes	0	0	6
10	R:R:K34	R:R:T33	7.51	No	No	0	4	7
11	R:R:E35	R:R:T33	15.52	No	No	0	5	7
12	R:R:E36	R:R:L40	5.3	No	No	0	6	5
13	R:R:R147	R:R:V126	5.23	Yes	No	0	3	4
14	R:R:A128	R:R:H143	4.39	No	No	0	5	3
15	R:R:C131	R:R:P132	5.65	No	No	0	9	9
16	R:R:C131	R:R:F138	11.17	No	Yes	0	9	4
17	R:R:C131	R:R:C170	7.28	No	No	0	9	9
18	R:R:I135	R:R:P132	5.08	Yes	No	0	7	9
19	R:R:D133	R:R:F138	5.97	No	Yes	0	2	4
20	R:R:D137	R:R:I135	8.4	No	Yes	0	5	7
21	R:R:F138	R:R:I135	10.05	Yes	Yes	0	4	7
22	R:R:D137	R:R:L174	5.43	No	No	0	5	3
23	R:R:F138	R:R:H140	19.23	Yes	No	0	4	3
24	R:R:K141	R:R:N139	5.6	No	No	0	3	4
25	R:R:E169	R:R:N139	5.26	No	No	0	5	4
26	R:R:E169	R:R:G142	6.55	No	No	0	5	5
27	R:R:A144	R:R:Y167	4	No	No	0	7	5
28	R:R:R147	R:R:Y145	6.17	Yes	No	0	3	4
29	R:R:N166	R:R:Y145	22.1	No	No	0	7	4
30	R:R:E155	R:R:R147	4.65	No	Yes	0	4	3
31	R:R:D149	R:R:E155	6.5	No	No	0	5	4
32	R:R:S153	R:R:W154	6.18	No	No	0	4	9
33	R:R:H160	R:R:V157	6.92	No	No	0	4	4
34	R:R:V157	R:R:W164	4.9	No	No	0	4	5
35	R:R:H160	R:R:R162	10.16	No	No	0	4	3
36	R:R:A165	R:R:Y167	5.34	No	No	0	7	5
37	R:R:N166	R:R:S168	8.94	No	No	0	7	6
38	R:R:Y191	R:R:Y195	17.87	Yes	Yes	1	7	7
39	R:R:M445	R:R:Y191	16.76	No	Yes	0	6	7
40	R:R:N448	R:R:Y191	6.98	Yes	Yes	1	6	7
41	R:R:F238	R:R:T192	5.19	No	No	0	7	7
42	R:R:G194	R:R:S449	3.71	No	No	0	9	9
43	R:R:R233	R:R:Y195	11.32	Yes	Yes	1	8	7
44	R:R:A234	R:R:Y195	4	No	Yes	0	8	7
45	R:R:N448	R:R:Y195	5.81	Yes	Yes	1	6	7
46	R:R:G452	R:R:S198	3.71	No	No	0	9	9
47	R:R:L199	R:R:M231	7.07	No	No	0	7	8
48	R:R:L199	R:R:V235	4.47	No	No	0	7	4
49	R:R:F453	R:R:S201	7.93	No	No	0	6	8
50	R:R:F227	R:R:L202	8.53	Yes	No	0	9	9
51	R:R:F230	R:R:L202	7.31	Yes	No	0	8	9
52	R:R:F461	R:R:V204	5.24	No	No	0	8	5
53	R:R:A205	R:R:F227	4.16	No	Yes	0	9	9
54	R:R:L209	R:R:N220	9.61	No	Yes	0	7	9
55	R:R:C460	R:R:L209	7.94	No	No	0	9	7
56	R:R:F212	R:R:Y211	12.38	Yes	No	0	7	2
57	R:R:F212	R:R:L215	3.65	Yes	No	0	7	9
58	R:R:F212	R:R:S473	5.28	Yes	No	0	7	4
59	R:R:E469	R:R:R214	9.3	No	No	0	9	7
60	R:R:L215	R:R:N220	4.12	No	Yes	0	9	9
61	R:R:E469	R:R:L215	5.3	No	No	0	9	9
62	R:R:C217	R:R:R219	6.96	No	No	0	8	9
63	R:R:T218	R:R:Y305	6.24	Yes	Yes	3	7	8
64	R:R:E317	R:R:T218	8.47	No	Yes	3	6	7
65	R:R:K318	R:R:T218	6.01	No	Yes	0	5	7
66	R:R:L321	R:R:T218	5.9	No	Yes	0	6	7
67	R:R:H223	R:R:N220	3.83	No	Yes	0	9	9
68	R:R:H225	R:R:Y221	11.98	Yes	No	0	8	7
69	R:R:L321	R:R:Y221	7.03	No	No	0	6	7
70	R:R:E302	R:R:H223	8.62	No	No	0	9	9
71	R:R:H225	R:R:M224	7.88	Yes	No	0	8	5
72	R:R:H225	R:R:W298	13.75	Yes	Yes	2	8	9
73	R:R:H225	R:R:T325	5.48	Yes	No	0	8	5
74	R:R:H225	R:R:W329	7.41	Yes	Yes	2	8	9
75	R:R:F230	R:R:L226	4.87	Yes	No	0	8	9
76	R:R:L226	R:R:W298	7.97	No	Yes	0	9	9
77	R:R:E302	R:R:L226	7.95	No	No	0	9	9
78	R:R:F227	R:R:V455	5.24	Yes	No	0	9	9
79	R:R:C460	R:R:F227	8.38	No	Yes	0	9	9
80	R:R:N295	R:R:S229	10.43	No	No	0	8	9
81	R:R:S229	R:R:W298	4.94	No	Yes	2	9	9
82	R:R:S229	R:R:W329	6.18	No	Yes	2	9	9
83	R:R:F230	R:R:N295	13.29	Yes	No	0	8	8
84	R:R:F230	R:R:I299	5.02	Yes	No	0	8	9
85	R:R:F230	R:R:Q451	10.54	Yes	No	0	8	9
86	R:R:F230	R:R:G452	4.52	Yes	No	0	8	9
87	R:R:F230	R:R:V455	5.24	Yes	No	0	8	9
88	R:R:F291	R:R:L232	10.96	Yes	No	0	5	8
89	R:R:L292	R:R:R233	6.07	Yes	Yes	1	6	8
90	R:R:N295	R:R:R233	13.26	No	Yes	0	8	8
91	R:R:R233	R:R:Y296	5.14	Yes	Yes	1	8	7
92	R:R:F288	R:R:I237	5.02	No	No	0	7	7
93	R:R:A284	R:R:K240	6.42	No	No	0	6	7
94	R:R:R282	R:R:V285	6.54	No	No	0	8	6
95	R:R:R282	R:R:R343	9.6	No	No	0	8	8
96	R:R:T286	R:R:W339	3.64	No	Yes	0	7	8
97	R:R:T286	R:R:V340	6.35	No	No	0	7	5
98	R:R:F287	R:R:F291	7.5	No	Yes	0	3	5
99	R:R:I363	R:R:L289	11.42	No	No	0	7	7
100	R:R:F291	R:R:Y290	6.19	Yes	Yes	0	5	9
101	R:R:T294	R:R:Y290	7.49	No	Yes	2	8	9
102	R:R:P332	R:R:Y290	4.17	Yes	Yes	2	9	9
103	R:R:A333	R:R:Y290	4	No	Yes	0	5	9
104	R:R:V336	R:R:Y290	7.57	No	Yes	0	7	9
105	R:R:L292	R:R:Y296	4.69	Yes	Yes	1	6	7
106	R:R:A293	R:R:P332	3.74	No	Yes	0	6	9
107	R:R:T294	R:R:W329	3.64	No	Yes	2	8	9
108	R:R:P332	R:R:T294	6.99	Yes	No	2	9	8
109	R:R:I367	R:R:Y296	4.84	No	Yes	0	7	7
110	R:R:I371	R:R:Y296	4.84	No	Yes	1	7	7
111	R:R:Y296	R:R:Y421	15.89	Yes	Yes	1	7	8
112	R:R:L331	R:R:Y297	7.03	No	Yes	0	4	6
113	R:R:P332	R:R:Y297	5.56	Yes	Yes	2	9	6
114	R:R:F335	R:R:Y297	7.22	Yes	Yes	2	5	6
115	R:R:S370	R:R:Y297	5.09	No	Yes	0	7	6
116	R:R:V301	R:R:W298	9.81	No	Yes	0	8	9
117	R:R:W298	R:R:W329	10.31	Yes	Yes	2	9	9
118	R:R:F327	R:R:L300	3.65	No	No	0	5	8
119	R:R:L300	R:R:S370	4.5	No	No	0	8	7
120	R:R:L300	R:R:L373	6.92	No	No	0	8	7
121	R:R:F324	R:R:V301	5.24	No	No	0	7	8
122	R:R:E302	R:R:L416	14.58	No	No	0	9	9
123	R:R:F417	R:R:G303	6.02	Yes	No	0	9	9
124	R:R:L304	R:R:L377	4.15	No	No	0	5	7
125	R:R:S308	R:R:Y305	3.82	No	Yes	0	7	8
126	R:R:L309	R:R:Y305	9.38	No	Yes	3	8	8
127	R:R:E317	R:R:Y305	14.59	No	Yes	3	6	8
128	R:R:F324	R:R:Y305	6.19	No	Yes	0	7	8
129	R:R:I381	R:R:L306	5.71	No	No	0	9	9
130	R:R:F311	R:R:H307	10.18	No	Yes	0	6	8
131	R:R:H307	R:R:L377	11.57	Yes	No	0	8	7
132	R:R:H307	R:R:N380	6.38	Yes	No	0	8	8
133	R:R:H307	R:R:I381	5.3	Yes	No	0	8	9
134	R:R:F315	R:R:S308	11.89	Yes	No	0	6	7
135	R:R:F315	R:R:L309	4.87	Yes	No	0	6	8
136	R:R:E317	R:R:L309	11.93	No	No	3	6	8
137	R:R:I310	R:R:V384	4.61	No	No	0	8	8
138	R:R:F315	R:R:M312	8.71	Yes	No	0	6	5
139	R:R:K319	R:R:S316	6.12	No	No	0	6	7
140	R:R:V326	R:R:W322	6.13	No	No	0	4	3
141	R:R:F327	R:R:L331	4.87	No	No	0	5	4
142	R:R:L331	R:R:V334	4.47	No	No	0	4	4
143	R:R:F335	R:R:P332	5.78	Yes	Yes	2	5	9
144	R:R:F335	R:R:V334	5.24	Yes	No	0	5	4
145	R:R:F335	R:R:P366	15.89	Yes	No	0	5	9
146	R:R:R343	R:R:W339	9	No	Yes	0	8	8
147	R:R:I362	R:R:W339	10.57	No	Yes	0	8	8
148	R:R:I363	R:R:W339	11.74	No	Yes	0	7	8
149	R:R:L346	R:R:V342	7.45	No	No	0	3	5
150	R:R:I362	R:R:N358	9.91	No	No	0	8	4
151	R:R:Q364	R:R:W361	13.14	No	No	0	7	8
152	R:R:V365	R:R:W361	12.26	No	No	0	5	8
153	R:R:L368	R:R:Q364	9.32	No	No	0	4	7
154	R:R:P366	R:R:V365	7.07	No	No	0	9	5
155	R:R:I371	R:R:Y421	16.92	No	Yes	1	7	8
156	R:R:M425	R:R:V372	6.09	No	No	0	6	4
157	R:R:F417	R:R:N374	13.29	Yes	No	0	9	9
158	R:R:F375	R:R:I422	13.82	No	No	0	7	5
159	R:R:F417	R:R:L377	3.65	Yes	No	0	9	7
160	R:R:F378	R:R:L413	6.09	Yes	No	4	9	9
161	R:R:F378	R:R:F417	7.5	Yes	Yes	4	9	9
162	R:R:F378	R:R:V419	3.93	Yes	No	0	9	7
163	R:R:T410	R:R:V382	6.35	No	No	0	9	7
164	R:R:L385	R:R:S409	7.51	No	No	0	8	9
165	R:R:L389	R:R:Q402	7.99	No	No	0	8	6
166	R:R:Q402	R:R:T392	7.09	No	No	0	6	7
167	R:R:D398	R:R:Q401	10.44	No	No	0	6	6
168	R:R:Q402	R:R:T399	4.25	No	No	0	6	6
169	R:R:T399	R:R:Y403	3.75	No	No	0	6	7
170	R:R:R400	R:R:Y403	7.2	No	No	0	8	7
171	R:R:K405	R:R:R404	3.71	No	No	0	8	6
172	R:R:K408	R:R:R404	7.43	No	No	0	8	6
173	R:R:L407	R:R:L411	5.54	No	No	0	8	8
174	R:R:I458	R:R:V412	6.14	No	No	0	8	8
175	R:R:F417	R:R:L413	4.87	Yes	No	4	9	9
176	R:R:M414	R:R:V419	7.61	No	No	0	8	7
177	R:R:F454	R:R:P415	8.67	No	No	0	6	9
178	R:R:I458	R:R:P415	5.08	No	No	0	8	9
179	R:R:L416	R:R:Y459	19.93	No	No	0	9	8
180	R:R:F447	R:R:H420	11.31	No	No	0	5	8
181	R:R:H420	R:R:N448	5.1	No	Yes	0	8	6
182	R:R:H420	R:R:Q451	12.36	No	No	0	8	9
183	R:R:E444	R:R:Y421	7.86	Yes	Yes	0	7	8
184	R:R:I422	R:R:M425	4.37	No	No	0	5	6
185	R:R:F424	R:R:V423	11.8	No	No	0	7	6
186	R:R:E444	R:R:F424	7	Yes	No	0	7	7
187	R:R:V432	R:R:Y429	5.05	No	No	0	5	6
188	R:R:L446	R:R:Y443	4.69	No	No	0	5	4
189	R:R:F447	R:R:Y443	10.32	No	No	0	5	4
190	R:R:E444	R:R:N448	3.94	Yes	Yes	0	7	6
191	R:R:F450	R:R:S449	11.89	No	No	0	7	9
192	R:R:F450	R:R:F453	4.29	No	No	0	7	6
193	R:R:I458	R:R:Y459	12.09	No	No	0	8	8
194	R:R:E465	R:R:N463	3.94	No	No	0	9	9
195	R:R:N463	R:R:V466	5.91	No	No	0	9	9
196	R:R:E465	R:R:E469	6.34	No	No	0	9	9
197	R:R:N220	R:R:R219	3.62	Yes	No	0	9	9
198	R:R:P130	R:R:V129	3.53	No	No	0	5	5
199	R:R:P158	R:R:V157	3.53	No	No	0	4	4
200	R:R:A456	R:R:S201	3.42	No	No	0	8	8
201	R:R:H216	R:R:R213	3.39	No	No	0	8	8
202	R:R:N358	R:R:W361	3.39	No	No	0	4	8
203	R:R:G464	R:R:N463	3.39	No	No	0	7	9
204	R:R:M414	R:R:P415	3.35	No	No	0	8	9
205	R:R:G418	R:R:Q451	3.29	No	No	0	9	9
206	R:R:A468	R:R:K472	3.21	No	No	0	5	7
207	R:R:A456	R:R:L202	3.15	No	No	0	8	9
208	R:R:A386	R:R:L406	3.15	No	No	0	6	8
209	R:R:F315	R:R:Y320	3.09	Yes	No	0	6	4
210	L:L:I5	L:L:V2	3.07	No	Yes	0	0	0
211	R:R:H143	R:R:P130	3.05	No	No	0	3	5
212	R:R:M224	R:R:V206	3.04	No	No	0	5	5
213	R:R:K388	R:R:V384	3.04	No	No	0	9	8
214	R:R:L174	R:R:V171	2.98	No	No	0	3	3
215	R:R:L406	R:R:T410	2.95	No	No	0	8	9
216	R:R:D149	R:R:S153	2.94	No	No	0	5	4
217	R:R:I371	R:R:I422	2.94	No	No	0	7	5
218	R:R:G323	R:R:Y320	2.9	No	No	0	1	4
219	R:R:I190	R:R:L446	2.85	No	No	0	6	5
220	R:R:I222	R:R:L321	2.85	No	No	0	9	6
221	R:R:L228	R:R:M231	2.83	No	No	0	4	8
222	R:R:E391	R:R:T387	2.82	No	No	0	7	7
223	R:R:K405	R:R:L389	2.82	No	No	0	8	8
224	R:R:G328	R:R:W298	2.81	No	Yes	0	9	9
225	R:R:G323	R:R:W322	2.81	No	No	0	1	3
226	R:R:A313	R:R:F314	2.77	No	No	0	7	7
227	R:R:I135	R:R:Q37	2.74	Yes	No	0	7	7
228	R:R:C170	R:R:Y167	2.69	No	No	0	9	5
229	R:R:A44	R:R:Y134	2.67	No	Yes	0	7	5
230	R:R:F288	R:R:S236	2.64	No	No	0	7	7
231	R:R:F291	R:R:S236	2.64	Yes	No	0	5	7
232	R:R:R383	R:R:V384	2.62	No	No	0	8	8
233	R:R:F378	R:R:T410	2.59	Yes	No	0	9	9
234	R:R:F461	R:R:I208	2.51	No	No	0	8	8
235	R:R:F212	R:R:I470	2.51	Yes	No	0	7	5
236	R:R:F454	R:R:I457	2.51	No	No	0	6	6
237	R:R:F461	R:R:I457	2.51	No	No	0	8	6
238	R:R:F288	R:R:K240	2.48	No	No	0	7	7
239	R:R:L187	R:R:R186	2.43	No	No	0	5	5
240	R:R:N380	R:R:R383	2.41	No	No	0	8	8
241	R:R:D398	R:R:R400	2.38	No	No	0	6	8
242	R:R:L228	R:R:W329	2.28	No	Yes	0	4	9
243	R:R:R147	R:R:W164	2	Yes	No	0	3	5
244	R:R:C148	R:R:G152	1.96	No	No	0	9	9
245	R:R:A279	R:R:G280	1.95	No	No	0	4	4
246	R:R:G194	R:R:V193	1.84	No	No	0	9	6
247	R:R:G194	R:R:V197	1.84	No	No	0	9	5
248	R:R:P428	R:R:T427	1.75	No	No	0	7	5
249	R:R:C148	R:R:V127	1.71	No	No	0	9	7
250	R:R:G188	R:R:L187	1.71	No	No	0	5	5
251	R:R:C281	R:R:V285	1.71	No	No	0	9	6
252	R:R:S341	R:R:V342	1.62	No	No	0	5	5
253	R:R:V127	R:R:V129	1.6	No	No	0	7	5
254	R:R:V235	R:R:V239	1.6	No	No	0	4	5
255	R:R:G142	R:R:H143	1.59	No	No	0	5	3
256	R:R:G159	R:R:H160	1.59	No	No	0	3	4
257	R:R:I362	R:R:V342	1.54	No	No	0	8	5
258	R:R:I379	R:R:V382	1.54	No	No	0	5	7
259	R:R:M231	R:R:T203	1.51	No	No	0	8	3
260	R:R:K388	R:R:T387	1.5	No	No	0	9	7
261	L:L:I5	R:R:K360	1.45	No	No	0	0	7
262	R:R:G330	R:R:Y290	1.45	No	Yes	0	7	9
263	R:R:I470	R:R:K471	1.45	No	No	0	5	5
264	R:R:K359	R:R:K360	1.44	No	No	0	3	7
265	R:R:K471	R:R:K472	1.44	No	No	0	5	7
266	R:R:I135	R:R:L41	1.43	Yes	No	0	7	8
267	R:R:E36	R:R:T33	1.41	No	No	0	6	7
268	R:R:L187	R:R:M445	1.41	No	No	0	5	6
269	R:R:E431	R:R:T430	1.41	No	No	0	3	5
270	R:R:K172	R:R:N139	1.4	No	No	0	3	4
271	R:R:L385	R:R:L406	1.38	No	No	0	8	8
272	R:R:D149	R:R:N151	1.35	No	No	0	5	5
273	R:R:F238	R:R:S196	1.32	No	No	0	7	7
274	R:R:R146	R:R:V127	1.31	No	No	0	8	7
275	R:R:F424	R:R:T427	1.3	No	No	0	7	5
276	R:R:M189	R:R:R186	1.24	No	No	0	4	5
277	R:R:E444	R:R:H442	1.23	Yes	No	0	7	5
278	R:R:F39	R:R:L40	1.22	No	No	0	7	5
279	R:R:T163	R:R:W154	1.21	No	No	0	5	9
280	R:R:D241	R:R:F238	1.19	No	No	0	8	7
281	R:R:L40	R:R:Y134	1.17	No	Yes	0	5	5
282	R:R:D133	R:R:Y134	1.15	No	Yes	0	2	5
283	R:R:Q47	R:R:Y134	1.13	No	Yes	0	6	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:V2	5.67	4	1	0
2	R:R:Y134	1.53	4	0	5
3	R:R:I135	5.54	5	0	7
4	R:R:F138	11.605	4	0	4
5	R:R:R147	4.5125	4	0	3
6	R:R:Y191	11.3575	4	1	7
7	R:R:Y195	8.698	5	1	7
8	R:R:F212	5.955	4	0	7
9	R:R:T218	6.655	4	3	7
10	R:R:N220	5.295	4	0	9
11	R:R:H225	9.3	5	2	8
12	R:R:F227	6.5775	4	0	9
13	R:R:F230	7.25571	7	0	8
14	R:R:R233	8.9475	4	1	8
15	R:R:Y290	5.145	6	2	9
16	R:R:F291	6.8225	4	0	5
17	R:R:L292	5.795	4	1	6
18	R:R:Y296	6.74167	6	1	7
19	R:R:Y297	6.225	4	2	6
20	R:R:W298	8.265	6	2	9
21	R:R:Y305	8.044	5	3	8
22	R:R:H307	8.3575	4	0	8
23	R:R:F315	7.14	4	0	6
24	R:R:W329	5.964	5	2	9
25	R:R:P332	5.248	5	2	9
26	R:R:F335	8.5325	4	2	5
27	R:R:W339	8.7375	4	0	8
28	R:R:F378	5.0275	4	4	9
29	R:R:F417	7.066	5	4	9
30	R:R:Y421	12.69	4	1	8
31	R:R:E444	5.73	5	0	7
32	R:R:N448	5.4575	4	1	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:V365	R:R:W361	44.8708	12.26	No	No	0	5	8
2	R:R:P366	R:R:V365	47.1479	7.07	No	No	0	9	5
3	R:R:F335	R:R:P366	49.4023	15.89	Yes	No	0	5	9
4	R:R:F335	R:R:P332	51.8388	5.78	Yes	Yes	2	5	9
5	R:R:P332	R:R:T294	65.5699	6.99	Yes	No	2	9	8
6	R:R:T294	R:R:W329	85.9615	3.64	No	Yes	2	8	9
7	R:R:S229	R:R:W329	39.1438	6.18	No	Yes	2	9	9
8	R:R:N295	R:R:S229	55.3	10.43	No	No	0	8	9
9	R:R:N295	R:R:R233	74.815	13.26	No	Yes	0	8	8
10	R:R:L292	R:R:R233	16.0082	6.07	Yes	Yes	1	6	8
11	R:R:R233	R:R:Y296	29.614	5.14	Yes	Yes	1	8	7
12	R:R:R233	R:R:Y195	31.356	11.32	Yes	Yes	1	8	7
13	R:R:Y191	R:R:Y195	15.7122	17.87	Yes	Yes	1	7	7
14	R:R:E444	R:R:N448	18.0348	3.94	Yes	Yes	0	7	6
15	L:L:E4	R:R:I237	13.8449	12.3	No	No	0	0	7
16	R:R:F288	R:R:I237	11.1351	5.02	No	No	0	7	7
17	R:R:F291	R:R:Y290	14.3687	6.19	Yes	Yes	0	5	9
18	R:R:M445	R:R:Y191	18.2626	16.76	No	Yes	0	6	7
19	R:R:F230	R:R:N295	49.2998	13.29	Yes	No	0	8	8
20	R:R:F230	R:R:L202	31.7887	7.31	Yes	No	0	8	9
21	R:R:A456	R:R:L202	23.1242	3.15	No	No	0	8	9
22	R:R:A456	R:R:S201	20.312	3.42	No	No	0	8	8
23	R:R:F453	R:R:S201	17.4769	7.93	No	No	0	6	8
24	R:R:F450	R:R:F453	14.6192	4.29	No	No	0	7	6
25	R:R:F450	R:R:S449	11.7386	11.89	No	No	0	7	9
26	R:R:W298	R:R:W329	57.338	10.31	Yes	Yes	2	9	9
27	R:R:L226	R:R:W298	79.1984	7.97	No	Yes	0	9	9
28	R:R:F230	R:R:L226	73.722	4.87	Yes	No	0	8	9
29	R:R:L228	R:R:W329	15.7919	2.28	No	Yes	0	4	9
30	R:R:L228	R:R:M231	13.2529	2.83	No	No	0	4	8
31	R:R:F227	R:R:L202	10.3723	8.53	Yes	No	0	9	9
32	R:R:F230	R:R:V455	10.8391	5.24	Yes	No	0	8	9
33	R:R:E302	R:R:L226	100	7.95	No	No	0	9	9
34	R:R:E302	R:R:L416	76.1129	14.58	No	No	0	9	9
35	R:R:L416	R:R:Y459	74.5076	19.93	No	No	0	9	8
36	R:R:I458	R:R:Y459	72.9022	12.09	No	No	0	8	8
37	R:R:I458	R:R:P415	69.4865	5.08	No	No	0	8	9
38	R:R:F454	R:R:P415	12.1143	8.67	No	No	0	6	9
39	R:R:E302	R:R:H223	39.5423	8.62	No	No	0	9	9
40	R:R:H223	R:R:N220	37.6067	3.83	No	Yes	0	9	9
41	R:R:L215	R:R:N220	32.1872	4.12	No	Yes	0	9	9
42	R:R:F212	R:R:L215	16.6458	3.65	Yes	No	0	7	9
43	R:R:E469	R:R:L215	14.3345	5.3	No	No	0	9	9
44	R:R:H225	R:R:W329	10.3495	7.41	Yes	Yes	2	8	9
45	R:R:H225	R:R:Y221	15.3023	11.98	Yes	No	0	8	7
46	R:R:L321	R:R:Y221	12.8658	7.03	No	No	0	6	7
47	R:R:V301	R:R:W298	42.662	9.81	No	Yes	0	8	9
48	R:R:F324	R:R:V301	40.7378	5.24	No	No	0	7	8
49	R:R:F324	R:R:Y305	38.7567	6.19	No	Yes	0	7	8
50	R:R:F230	R:R:Q451	32.0961	10.54	Yes	No	0	8	9
51	R:R:N358	R:R:W361	35.5346	3.39	No	No	0	4	8
52	R:R:I362	R:R:N358	33.1436	9.91	No	No	0	8	4
53	R:R:I362	R:R:W339	23.3519	10.57	No	Yes	0	8	8
54	R:R:R343	R:R:W339	10.6	9	No	Yes	0	8	8
55	R:R:I371	R:R:Y296	10.805	4.84	No	Yes	1	7	7
56	R:R:M414	R:R:P415	58.7043	3.35	No	No	0	8	9
57	R:R:M414	R:R:V419	56.8257	7.61	No	No	0	8	7
58	R:R:F378	R:R:V419	54.9243	3.93	Yes	No	0	9	7
59	R:R:F378	R:R:F417	36.6048	7.5	Yes	Yes	4	9	9
60	R:R:F417	R:R:L377	30.3313	3.65	Yes	No	0	9	7
61	R:R:S308	R:R:Y305	16.3498	3.82	No	Yes	0	7	8
62	R:R:L309	R:R:Y305	16.3384	9.38	No	Yes	3	8	8
63	R:R:H307	R:R:L377	25.9137	11.57	Yes	No	0	8	7
64	R:R:H307	R:R:N380	16.8052	6.38	Yes	No	0	8	8
65	R:R:F315	R:R:S308	14.0726	11.89	Yes	No	0	6	7
66	R:R:F315	R:R:L309	14.7558	4.87	Yes	No	0	6	8
67	R:R:N380	R:R:R383	14.4711	2.41	No	No	0	8	8
68	R:R:R383	R:R:V384	12.1143	2.62	No	No	0	8	8
69	R:R:F315	R:R:Y320	19.2986	3.09	Yes	No	0	6	4
70	R:R:G323	R:R:Y320	14.5053	2.9	No	No	0	1	4
71	R:R:I371	R:R:I422	10.1446	2.94	No	No	0	7	5
72	R:R:F378	R:R:T410	16.8052	2.59	Yes	No	0	9	9
73	R:R:H420	R:R:Q451	27.9745	12.36	No	No	0	8	9
74	R:R:F447	R:R:H420	11.0099	11.31	No	No	0	5	8
75	R:R:E444	R:R:F424	15.1087	7	Yes	No	0	7	7
76	L:L:I5	L:L:V2	14.0271	3.07	No	Yes	0	0	0
77	R:R:L187	R:R:M445	14.6533	1.41	No	No	0	5	6
78	R:R:S229	R:R:W298	16.8507	4.94	No	Yes	2	9	9
79	R:R:H225	R:R:W298	15.0632	13.75	Yes	Yes	2	8	9
80	R:R:H420	R:R:N448	19.1506	5.1	No	Yes	0	8	6
81	R:R:T294	R:R:Y290	18.6724	7.49	No	Yes	2	8	9
82	R:R:P332	R:R:Y297	14.1296	5.56	Yes	Yes	2	9	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:S1	R:R:Q364	4.33	0	No	No	0	7	0	1
L:L:V2	R:R:L292	4.47	1	Yes	Yes	0	6	0	1
L:L:V2	R:R:Y296	5.05	1	Yes	Yes	0	7	0	1
L:L:V2	R:R:Y421	10.09	1	Yes	Yes	0	8	0	1
L:L:S3	R:R:Y191	3.82	0	No	Yes	0	7	0	1
L:L:S3	R:R:E444	8.62	0	No	Yes	0	7	0	1
L:L:E4	R:R:Y195	4.49	0	No	Yes	0	7	0	1
L:L:E4	R:R:I237	12.3	0	No	No	0	7	0	1
L:L:E4	R:R:L292	7.95	0	No	Yes	0	6	0	1
R:R:Y191	R:R:Y195	17.87	1	Yes	Yes	7	7	1	1
R:R:M445	R:R:Y191	16.76	0	No	Yes	6	7	2	1
R:R:N448	R:R:Y191	6.98	1	Yes	Yes	6	7	2	1
R:R:R233	R:R:Y195	11.32	1	Yes	Yes	8	7	2	1
R:R:A234	R:R:Y195	4	0	No	Yes	8	7	2	1
R:R:N448	R:R:Y195	5.81	1	Yes	Yes	6	7	2	1
R:R:L292	R:R:R233	6.07	1	Yes	Yes	6	8	1	2
R:R:R233	R:R:Y296	5.14	1	Yes	Yes	8	7	2	1
R:R:F288	R:R:I237	5.02	0	No	No	7	7	2	1
R:R:L292	R:R:Y296	4.69	1	Yes	Yes	6	7	1	1
R:R:I367	R:R:Y296	4.84	0	No	Yes	7	7	2	1
R:R:I371	R:R:Y296	4.84	1	No	Yes	7	7	2	1
R:R:Y296	R:R:Y421	15.89	1	Yes	Yes	7	8	1	1
R:R:Q364	R:R:W361	13.14	0	No	No	7	8	1	2
R:R:L368	R:R:Q364	9.32	0	No	No	4	7	2	1
R:R:I371	R:R:Y421	16.92	1	No	Yes	7	8	2	1
R:R:E444	R:R:Y421	7.86	0	Yes	Yes	7	8	1	1
R:R:E444	R:R:F424	7	0	Yes	No	7	7	1	2
R:R:E444	R:R:N448	3.94	0	Yes	Yes	7	6	1	2
L:L:I5	R:R:K360	1.45	0	No	No	0	7	0	1
R:R:K359	R:R:K360	1.44	0	No	No	3	7	2	1
R:R:E444	R:R:H442	1.23	0	Yes	No	7	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7VVO_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.64
Number of Linked Nodes	271
Number of Links	283
Number of Hubs	32
Number of Links mediated by Hubs	121
Number of Communities	4
Number of Nodes involved in Communities	25
Number of Links involved in Communities	33

Path Summary
Number Of Nodes in MetaPath	83
Number Of Links MetaPath	82
Number of Shortest Paths	24584
Length Of Smallest Path	3
Average Path Length	12.3382
Length of Longest Path	33
Minimum Path Strength	1.14
Average Path Strength	7.46005
Maximum Path Strength	17.315
Minimum Path Correlation	0.7
Average Path Correlation	0.971192
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	12.5
Average % Of Corr. Nodes	73.5008
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	33.6576
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• identical protein binding • protein binding • binding • protein homodimerization activity • protein dimerization activity • amide binding • peptide hormone binding • hormone binding • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • parathyroid hormone receptor activity • developmental process • multicellular organismal process • ossification • bone mineralization • animal organ development • anatomical structure development • biomineral tissue development • tissue development • multicellular organism development • skeletal system development • system development • cell population proliferation • cellular process • cellular response to stimulus
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • ossification • bone mineralization • animal organ development • anatomical structure development • biomineral tissue development • tissue development • multicellular organism development • skeletal system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • osteoblast development • cellular developmental process • cell differentiation • cell development • osteoblast differentiation • embryo development ending in birth or egg hatching • chordate embryonic development • embryo development • in utero embryonic development • anatomical structure maturation • cell maturation • developmental maturation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • cell surface receptor signaling pathway • negative regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • phospholipase C-activating G protein-coupled receptor signaling pathway • connective tissue development • chondrocyte differentiation • cartilage development • regulation of inositol phosphate biosynthetic process • alcohol metabolic process • positive regulation of phosphate metabolic process • inositol phosphate metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • phosphate-containing compound metabolic process • polyol biosynthetic process • small molecule metabolic process • phosphorus metabolic process • regulation of carbohydrate metabolic process • regulation of biosynthetic process • carbohydrate metabolic process • polyol metabolic process • positive regulation of phosphorus metabolic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • carbohydrate biosynthetic process • primary metabolic process • positive regulation of inositol phosphate biosynthetic process • biosynthetic process • organophosphate metabolic process • organophosphate biosynthetic process • inositol phosphate biosynthetic process • alcohol biosynthetic process • metabolic process • regulation of phosphorus metabolic process • positive regulation of carbohydrate metabolic process • regulation of carbohydrate biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • multicellular organismal-level homeostasis • tissue remodeling • bone remodeling • anatomical structure homeostasis • tissue homeostasis • bone resorption • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • cellular anatomical structure • organelle lumen • organelle • membraneless organelle • nuclear lumen
Gene Ontology	Cellular Component	• membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • cellular anatomical structure • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • apical part of cell • membrane • plasma membrane • plasma membrane region • apical plasma membrane • cytoplasm • cytosol • basal part of cell • basal plasma membrane • basolateral plasma membrane • protein-containing complex • receptor complex • parathyroid hormone receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • type 1 parathyroid hormone receptor binding • molecular function activator activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • peptide hormone receptor binding • hormone receptor binding • hormone activity • response to stimulus • response to chemical • response to xenobiotic stimulus • response to parathyroid hormone • response to hormone • response to endogenous stimulus • magnesium ion homeostasis • inorganic ion homeostasis • chemical homeostasis • homeostatic process • monoatomic ion homeostasis • monoatomic cation homeostasis • developmental process • multicellular organismal process • ossification • bone mineralization • animal organ development • anatomical structure development • biomineral tissue development • tissue development • multicellular organismal-level homeostasis • homeostasis of number of cells within a tissue • anatomical structure homeostasis • tissue homeostasis • homeostasis of number of cells • biosynthetic process • metabolic process • cellular process • macromolecule metabolic process • macromolecule biosynthetic process • multicellular organism development • skeletal system development • system development • regulation of biosynthetic process • regulation of biological process • regulation of cellular process • biological regulation • positive regulation of biological process • regulation of macromolecule metabolic process • gene expression • positive regulation of macromolecule biosynthetic process • regulation of gene expression • positive regulation of metabolic process • positive regulation of gene expression • positive regulation of biosynthetic process • regulation of macromolecule biosynthetic process • positive regulation of macromolecule metabolic process • regulation of metabolic process • positive regulation of cellular process • RNA metabolic process • primary metabolic process • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • RNA biosynthetic process • nucleobase-containing compound metabolic process • DNA-templated transcription • nucleic acid biosynthetic process • transcription by RNA polymerase II • negative regulation of apoptotic process in bone marrow cell • negative regulation of programmed cell death • apoptotic process in bone marrow cell • regulation of apoptotic process in bone marrow cell • regulation of apoptotic process • negative regulation of biological process • regulation of programmed cell death • cell death • negative regulation of apoptotic process • negative regulation of cellular process • apoptotic process • programmed cell death • regulation of generation of precursor metabolites and energy • regulation of primary metabolic process • positive regulation of glycogen metabolic process • regulation of small molecule metabolic process • small molecule metabolic process • carbohydrate biosynthetic process • hexose metabolic process • positive regulation of glucose metabolic process • positive regulation of glycogen biosynthetic process • energy reserve metabolic process • positive regulation of carbohydrate metabolic process • regulation of glycogen metabolic process • monosaccharide metabolic process • regulation of glycogen biosynthetic process • glucan biosynthetic process • energy derivation by oxidation of organic compounds • regulation of glucan biosynthetic process • regulation of polysaccharide metabolic process • polysaccharide metabolic process • glucan metabolic process • regulation of carbohydrate metabolic process • regulation of glucose metabolic process • carbohydrate metabolic process • polysaccharide biosynthetic process • glycogen metabolic process • generation of precursor metabolites and energy • glycogen biosynthetic process • regulation of polysaccharide biosynthetic process • regulation of carbohydrate biosynthetic process • positive regulation of small molecule metabolic process • glucose metabolic process • phosphate ion homeostasis • signaling • cell-cell signaling • cell communication • intracellular calcium ion homeostasis • calcium ion homeostasis • cellular homeostasis • intracellular monoatomic cation homeostasis • intracellular chemical homeostasis • intracellular monoatomic ion homeostasis • regulation of developmental process • regulation of biomineral tissue development • regulation of bone mineralization • positive regulation of ossification • positive regulation of developmental process • positive regulation of biomineral tissue development • regulation of multicellular organismal process • regulation of multicellular organismal development • positive regulation of bone mineralization • positive regulation of multicellular organismal process • regulation of ossification • response to alcohol • response to oxygen-containing compound • response to ethanol • cellular response to stimulus • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • response to metal ion • response to lead ion • cell population proliferation • positive regulation of cell population proliferation • positive regulation of cell proliferation in bone marrow • cell proliferation in bone marrow • regulation of cell proliferation in bone marrow • regulation of cell population proliferation • response to nutrient levels • response to vitamin D • response to lipid • response to nutrient • response to vitamin • hormone-mediated signaling pathway • apoptotic signaling pathway • cellular response to endogenous stimulus • cellular response to chemical stimulus • hormone-mediated apoptotic signaling pathway • cellular response to hormone stimulus • nucleoside phosphate metabolic process • ribose phosphate metabolic process • cAMP metabolic process • cyclic purine nucleotide metabolic process • carbohydrate derivative metabolic process • nucleotide metabolic process • cyclic nucleotide metabolic process • purine-containing compound metabolic process • purine nucleotide metabolic process • ribonucleotide metabolic process • organophosphate metabolic process • nucleobase-containing small molecule metabolic process • phosphate-containing compound metabolic process • purine ribonucleotide metabolic process • phosphorus metabolic process • regulation of cartilage development • regulation of chondrocyte differentiation • connective tissue development • cellular developmental process • negative regulation of cartilage development • negative regulation of chondrocyte differentiation • regulation of cell differentiation • cell differentiation • negative regulation of cell differentiation • negative regulation of developmental process • chondrocyte differentiation • negative regulation of multicellular organismal process • cartilage development • negative regulation of metabolic process • negative regulation of gene expression • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of macromolecule metabolic process • regulation of localization • hexose transmembrane transport • D-glucose import • transport • carbohydrate transport • positive regulation of D-glucose transmembrane transport • localization • positive regulation of transmembrane transport • regulation of D-glucose import • positive regulation of D-glucose import • regulation of transport • establishment of localization • transmembrane transport • regulation of transmembrane transport • positive regulation of transport • D-glucose transmembrane transport • regulation of D-glucose transmembrane transport • monosaccharide transmembrane transport • carbohydrate transmembrane transport • positive regulation of cell communication • regulation of signaling • positive regulation of signal transduction • regulation of signal transduction • positive regulation of response to stimulus • regulation of response to stimulus • regulation of cell communication • positive regulation of signaling • response to cadmium ion • small GTPase-mediated signal transduction • Rho protein signal transduction • intracellular signal transduction • intracellular signaling cassette • regulation of leukocyte proliferation • osteoclast proliferation • regulation of osteoclast proliferation • positive regulation of osteoclast proliferation • leukocyte proliferation • positive regulation of leukocyte proliferation • bone maturation • regulation of bone mineralization involved in bone maturation • negative regulation of biomineral tissue development • negative regulation of bone mineralization • ossification involved in bone maturation • bone development • bone mineralization involved in bone maturation • developmental maturation • negative regulation of bone mineralization involved in bone maturation • negative regulation of ossification • anatomical structure maturation • animal organ maturation • positive regulation of DNA-templated transcription • regulation of RNA metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of transcription by RNA polymerase II • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • regulation of inositol phosphate biosynthetic process • alcohol metabolic process • positive regulation of phosphate metabolic process • inositol phosphate metabolic process • polyol biosynthetic process • polyol metabolic process • positive regulation of phosphorus metabolic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • positive regulation of inositol phosphate biosynthetic process • organophosphate biosynthetic process • inositol phosphate biosynthetic process • alcohol biosynthetic process • regulation of phosphorus metabolic process • positive regulation of alcohol biosynthetic process • tissue remodeling • bone remodeling • bone resorption • response to fibroblast growth factor • response to growth factor • extracellular region • extracellular space • G-protein beta-subunit binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to monoamine stimulus • response to ketone • response to prostaglandin • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to stress • response to oxygen levels • response to abiotic stimulus • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • organelle membrane • cell projection membrane • synapse • cell junction • cell body • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • adaptive thermogenesis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • regulation of protein transport • protein secretion • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • extracellular exosome • extracellular vesicle • extracellular organelle • vesicle • extracellular membrane-bounded organelle • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • endomembrane system • trans-Golgi network
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q03431
Sequence	>7VVO_nogp_Chain_R T K E E Q I F L L H R A Q A Q C E K R L V V A V P C P D Y I Y D F N H K G H A Y R R C D R N G S W E L V P G H N R T W A N Y S E C V K F L R L G M I Y T V G Y S V S L A S L T V A V L I L A Y F R R L H C T R N Y I H M H L F L S F M L R A V S I F V K D A G C R V A V T F F L Y F L A T N Y Y W I L V E G L Y L H S L I F M A F F S E K K Y L W G F T V F G W G L P A V F V A V W V S V R A T L A N G N K K W I I Q V P I L A S I V L N F I L F I N I V R V L A T K L R E T D T R Q Q Y R K L L K S T L V L M P L F G V H Y I V F M A T P Y T E V H Y E M L F N S F Q G F F V A I I Y C F C N G E V Q A E I K K S W S R W Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8GW8	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371	Gs/β1/γ2	2.9	2023-06-14	doi.org/10.1038/s41586-023-06169-3
	8GW8 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371		2.9	2023-06-14	doi.org/10.1038/s41586-023-06169-3
	8JR9	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371	chim(NtGi1-Gs)/β1/γ2	2.57	2023-08-02	doi.org/10.1038/s41586-023-06467-w
	8JR9 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371		2.57	2023-08-02	doi.org/10.1038/s41586-023-06467-w
	7VVJ	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/β1/γ2	3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVJ (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVK	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.3	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVK (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.3	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVL	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVL (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVM	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVM (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.2	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVN	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVN (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.8	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	4.1	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	7VVO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		4.1	2022-08-03	doi.org/10.1016/j.molcel.2022.07.003
	8FLQ	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.55	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLQ (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.55	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLR	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/β1/γ2	2.94	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLR (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		2.94	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLS	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/β1/γ2	3.09	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLS (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-		3.09	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLT	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	M-PTH(1-14)	-	Gs/β1/γ2	3.03	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLT (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	M-PTH(1-14)	-		3.03	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLU	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-	Gs/β1/γ2	2.76	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8FLU (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-		2.76	2023-04-26	doi.org/10.1016/j.str.2023.04.002
	8HA0	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/β1/γ2	2.62	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HA0 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.62	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAF	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	chim(NtGi1-Gs)/β1/γ2	3.25	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAF (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		3.25	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/β1/γ2	3.76	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	8HAO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.76	2022-12-21	doi.org/10.1038/s41401-022-01032-z
	6FJ3	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	-	2.5	2018-11-21	doi.org/10.1038/s41594-018-0151-4
	6NBF	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	3	2019-04-17	doi.org/10.1126/science.aav7942
	6NBF (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		3	2019-04-17	doi.org/10.1126/science.aav7942
	6NBH	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	3.5	2019-04-17	doi.org/10.1126/science.aav7942
	6NBH (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		3.5	2019-04-17	doi.org/10.1126/science.aav7942
	6NBI	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	4	2019-04-17	doi.org/10.1126/science.aav7942
	6NBI (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		4	2019-04-17	doi.org/10.1126/science.aav7942
	9B5Y	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-	chim(NtGi1-Gq)/β1/γ2	3.49	2025-03-19	doi.org/10.1073/pnas.2426178122
	9B5Y (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-		3.49	2025-03-19	doi.org/10.1073/pnas.2426178122
	7Y35	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/β1/γ2	2.9	2023-07-05	To be published
	7Y35 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-		2.9	2023-07-05	To be published
	7Y36	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Teriparatide	-	Gs/β1/γ2	2.8	2023-07-05	To be published
	7Y36 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Teriparatide	-		2.8	2023-07-05	To be published
	9JR2	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-10-16	To be published
	9JR2 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2024-10-16	To be published
	9JR3	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-10-16	To be published
	9JR3 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2024-10-16	To be published

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