psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	A:A:Q12	A:A:R13	8.18	No	No	0	2	4
2	A:A:E16	A:A:R20	12.79	No	No	0	4	3
3	A:A:K17	A:A:R20	7.43	No	No	0	4	3
4	A:A:Q19	B:B:D83	9.14	No	Yes	7	4	8
5	A:A:Q19	B:B:T86	7.09	No	No	7	4	6
6	A:A:Q19	B:B:N88	13.2	No	Yes	7	4	7
7	A:A:R20	B:B:N88	3.62	No	Yes	0	3	7
8	A:A:E27	A:A:N23	10.52	No	No	7	6	7
9	A:A:N23	B:B:N88	12.26	No	Yes	7	7	7
10	A:A:N23	B:B:K89	8.39	No	Yes	7	7	9
11	A:A:E27	A:A:K24	4.05	No	No	0	6	4
12	A:A:I26	B:B:A92	4.87	No	No	0	9	6
13	A:A:E27	B:B:K89	4.05	No	Yes	7	6	9
14	A:A:K32	A:A:Q29	5.42	No	No	0	4	4
15	A:A:D33	A:A:Q29	13.05	No	No	0	5	4
16	A:A:L30	B:B:K78	4.23	No	No	0	5	8
17	A:A:D33	B:B:K78	6.91	No	No	0	5	8
18	A:A:K34	A:A:R38	9.9	No	No	0	4	4
19	A:A:K34	B:B:L55	5.64	No	No	0	4	6
20	A:A:R42	A:A:Y37	21.61	No	No	0	9	4
21	A:A:Y37	B:B:L55	4.69	No	No	22	4	6
22	A:A:Y37	B:B:D76	4.6	No	Yes	22	4	9
23	A:A:A39	R:R:F315	4.16	No	No	0	5	6
24	A:A:F219	A:A:H41	3.39	Yes	No	0	8	6
25	A:A:H41	A:A:T242	10.95	No	No	0	6	8
26	A:A:H41	R:R:F314	9.05	No	Yes	0	6	7
27	A:A:F222	A:A:R42	4.28	Yes	No	0	7	9
28	A:A:F219	A:A:L43	6.09	Yes	No	0	8	7
29	A:A:I245	A:A:L43	5.71	No	No	0	7	7
30	A:A:F238	A:A:L44	14.61	Yes	No	0	9	9
31	A:A:I244	A:A:L44	5.71	No	No	0	8	9
32	A:A:K53	A:A:L45	7.05	Yes	No	15	9	8
33	A:A:L45	A:A:M221	4.24	No	No	0	8	8
34	A:A:D223	A:A:L45	6.79	No	No	15	9	8
35	A:A:G47	A:A:S51	3.71	No	Yes	15	9	9
36	A:A:G47	A:A:K53	5.23	No	Yes	15	9	9
37	A:A:D249	A:A:N50	8.08	No	No	18	8	9
38	A:A:D252	A:A:N50	10.77	Yes	No	18	8	9
39	A:A:N50	A:A:R265	18.08	No	Yes	18	9	9
40	A:A:G52	A:A:S51	3.71	No	Yes	0	9	9
41	A:A:K53	A:A:S51	4.59	Yes	Yes	15	9	9
42	A:A:S51	A:A:V247	6.46	Yes	Yes	15	9	7
43	A:A:D223	A:A:K53	9.68	No	Yes	15	9	9
44	A:A:K53	A:A:V247	3.04	Yes	Yes	15	9	7
45	A:A:I56	A:A:V247	4.61	No	Yes	0	7	7
46	A:A:T210	A:A:V57	4.76	No	No	0	7	7
47	A:A:N371	A:A:Q59	5.28	Yes	No	0	9	9
48	A:A:F212	A:A:M60	7.46	Yes	No	0	9	9
49	A:A:G206	B:B:N119	3.39	No	No	0	8	9
50	A:A:F222	A:A:I207	3.77	Yes	No	17	7	9
51	A:A:I207	A:A:V224	3.07	No	No	0	9	9
52	A:A:I207	B:B:W99	3.52	No	Yes	17	9	9
53	A:A:D223	A:A:F208	5.97	No	No	0	9	5
54	A:A:E209	A:A:H220	12.31	No	No	17	9	7
55	A:A:E209	A:A:F222	3.5	No	Yes	17	9	7
56	A:A:H220	A:A:K211	14.41	No	No	0	7	4
57	A:A:F212	A:A:F219	17.15	Yes	Yes	0	9	8
58	A:A:F212	A:A:M221	3.73	Yes	No	0	9	8
59	A:A:K216	A:A:Q213	5.42	No	No	0	4	3
60	A:A:N218	A:A:Q213	10.56	No	No	0	4	3
61	A:A:R373	A:A:V214	3.92	Yes	No	10	5	6
62	A:A:F376	A:A:V214	10.49	Yes	No	10	8	6
63	A:A:D215	A:A:R373	10.72	No	Yes	10	5	5
64	A:A:D215	A:A:F376	7.17	No	Yes	10	5	8
65	A:A:F219	A:A:V217	5.24	Yes	No	10	8	5
66	A:A:F376	A:A:V217	6.55	Yes	No	10	8	5
67	A:A:V217	R:R:F314	5.24	No	Yes	10	5	7
68	A:A:F219	A:A:F376	3.22	Yes	Yes	10	8	8
69	A:A:C379	A:A:F219	6.98	No	Yes	0	8	8
70	A:A:F222	A:A:H220	16.97	Yes	No	17	7	7
71	A:A:F222	B:B:W99	18.04	Yes	Yes	17	7	9
72	A:A:V224	A:A:W234	13.48	No	Yes	0	9	9
73	A:A:Q227	A:A:W234	6.57	Yes	Yes	0	9	9
74	A:A:Q227	B:B:L117	3.99	Yes	No	0	9	9
75	A:A:Q227	B:B:N119	6.6	Yes	No	0	9	9
76	A:A:Q227	B:B:Y145	6.76	Yes	Yes	0	9	8
77	A:A:E230	A:A:R228	9.3	Yes	No	1	9	9
78	A:A:R228	B:B:T164	5.17	No	No	0	9	6
79	A:A:R228	B:B:D186	8.34	No	Yes	1	9	9
80	A:A:E230	A:A:R232	4.65	Yes	No	0	9	8
81	A:A:E230	B:B:D186	5.2	Yes	Yes	1	9	9
82	A:A:R231	A:A:W234	7	No	Yes	0	9	9
83	A:A:L272	A:A:R231	9.72	No	No	0	8	9
84	A:A:R232	B:B:D228	13.1	No	Yes	0	8	9
85	A:A:K233	B:B:Y145	3.58	Yes	Yes	1	9	8
86	A:A:K233	B:B:M188	8.64	Yes	No	1	9	8
87	A:A:K233	B:B:C204	4.85	Yes	Yes	1	9	7
88	A:A:K233	B:B:D228	8.3	Yes	Yes	1	9	9
89	A:A:K233	B:B:N230	4.2	Yes	No	1	9	9
90	A:A:K233	B:B:D246	4.15	Yes	No	1	9	9
91	A:A:I235	A:A:W234	3.52	No	Yes	0	9	9
92	A:A:F238	A:A:W234	4.01	Yes	Yes	0	9	9
93	A:A:Q236	A:A:W281	5.48	No	Yes	5	8	5
94	A:A:Q236	B:B:R314	3.5	No	Yes	5	8	8
95	A:A:C237	B:B:Q75	4.58	No	Yes	0	8	9
96	A:A:C237	B:B:M101	4.86	No	Yes	0	8	9
97	A:A:F238	A:A:V241	5.24	Yes	No	0	9	9
98	A:A:F238	B:B:W99	14.03	Yes	Yes	0	9	9
99	A:A:D240	A:A:N239	8.08	No	No	5	6	8
100	A:A:N239	B:B:K57	8.39	No	Yes	5	8	9
101	A:A:N239	B:B:W332	13.56	No	Yes	5	8	9
102	A:A:D240	B:B:K57	6.91	No	Yes	5	6	9
103	A:A:I285	A:A:V241	3.07	No	No	0	7	9
104	A:A:C379	A:A:T242	3.38	No	No	0	8	8
105	A:A:A243	A:A:I288	3.25	No	No	0	8	9
106	A:A:I244	A:A:I285	5.89	No	No	0	8	7
107	A:A:F246	A:A:L272	7.31	No	No	0	9	8
108	A:A:N292	A:A:V247	4.43	No	Yes	0	9	7
109	A:A:F345	A:A:V248	6.55	Yes	No	0	8	7
110	A:A:D249	A:A:D252	7.98	No	Yes	18	8	8
111	A:A:D249	A:A:K293	17.97	No	No	0	8	9
112	A:A:L291	A:A:S250	4.5	No	No	0	8	6
113	A:A:Q294	A:A:S250	4.33	Yes	No	2	6	6
114	A:A:L297	A:A:S250	3	Yes	No	2	8	6
115	A:A:L296	A:A:S251	3	Yes	No	0	6	9
116	A:A:K300	A:A:S251	6.12	Yes	No	0	9	9
117	A:A:D252	A:A:N264	5.39	Yes	No	18	8	9
118	A:A:D252	A:A:R265	13.1	Yes	Yes	18	8	9
119	A:A:L297	A:A:Y253	3.52	Yes	Yes	2	8	8
120	A:A:K300	A:A:Y253	17.91	Yes	Yes	2	9	8
121	A:A:S306	A:A:Y253	6.36	No	Yes	2	7	8
122	A:A:I308	A:A:Y253	12.09	No	Yes	0	7	8
123	A:A:N264	A:A:R265	4.82	No	Yes	18	9	9
124	A:A:N264	A:A:Y311	4.65	No	No	0	9	6
125	A:A:E268	A:A:R265	9.3	No	Yes	0	9	9
126	A:A:F312	A:A:L266	4.87	Yes	No	0	8	8
127	A:A:I341	A:A:L266	4.28	No	No	0	8	8
128	A:A:L270	A:A:Q267	5.32	No	No	0	6	4
129	A:A:N271	A:A:Q267	5.28	No	No	0	5	4
130	A:A:E344	A:A:L270	3.98	Yes	No	0	5	6
131	A:A:F345	A:A:L270	9.74	Yes	No	0	8	6
132	A:A:I276	A:A:L272	4.28	No	No	0	8	8
133	A:A:F273	A:A:W277	5.01	Yes	Yes	2	9	6
134	A:A:F273	A:A:V287	5.24	Yes	No	2	9	6
135	A:A:F273	A:A:F345	5.36	Yes	Yes	0	9	8
136	A:A:F273	A:A:I348	6.28	Yes	No	0	9	4
137	A:A:F273	A:A:S349	3.96	Yes	Yes	2	9	7
138	A:A:C359	A:A:F273	4.19	No	Yes	2	5	9
139	A:A:K274	A:A:N278	5.6	No	No	0	5	8
140	A:A:V287	A:A:W277	3.68	No	Yes	2	6	6
141	A:A:S349	A:A:W277	11.12	Yes	Yes	2	7	6
142	A:A:S352	A:A:W277	3.71	No	Yes	0	5	6
143	A:A:H357	A:A:W277	29.62	No	Yes	2	7	6
144	A:A:N278	A:A:S352	4.47	No	No	0	8	5
145	A:A:N279	A:A:W281	3.39	No	Yes	0	8	5
146	A:A:L282	A:A:N279	10.98	No	No	0	9	8
147	A:A:R280	A:A:W281	22.99	No	Yes	5	5	5
148	A:A:R280	A:A:R283	5.33	No	No	0	5	3
149	A:A:R280	B:B:D290	5.96	No	Yes	5	5	6
150	A:A:W281	B:B:D290	8.93	Yes	Yes	5	5	6
151	A:A:W281	B:B:R314	23.99	Yes	Yes	5	5	8
152	A:A:W281	B:B:W332	4.69	Yes	Yes	5	5	9
153	A:A:R283	A:A:R356	12.79	No	Yes	0	3	2
154	A:A:I382	A:A:S286	6.19	No	No	0	6	8
155	A:A:F290	A:A:I288	3.77	Yes	No	0	9	9
156	A:A:D378	A:A:I288	9.8	No	No	0	7	9
157	A:A:L289	A:A:L291	6.92	Yes	No	0	9	8
158	A:A:F345	A:A:L289	7.31	Yes	Yes	0	8	9
159	A:A:C359	A:A:L289	3.17	No	Yes	0	5	9
160	A:A:L289	A:A:P361	4.93	Yes	No	0	9	5
161	A:A:F290	A:A:H362	6.79	Yes	No	0	9	9
162	A:A:F290	A:A:T364	6.49	Yes	No	23	9	9
163	A:A:F290	A:A:N371	4.83	Yes	Yes	23	9	9
164	A:A:F290	A:A:I375	5.02	Yes	No	0	9	9
165	A:A:F363	A:A:L291	3.65	Yes	No	0	5	8
166	A:A:K293	A:A:N292	8.39	No	No	0	9	9
167	A:A:N292	A:A:T364	4.39	No	No	0	9	9
168	A:A:K293	A:A:L296	4.23	No	Yes	0	9	6
169	A:A:L297	A:A:Q294	5.32	Yes	Yes	2	8	6
170	A:A:K338	A:A:Q294	8.14	Yes	Yes	2	5	6
171	A:A:F363	A:A:Q294	10.54	Yes	Yes	2	5	6
172	A:A:D295	A:A:L296	6.79	No	Yes	0	9	6
173	A:A:K300	A:A:S306	9.18	Yes	No	2	9	7
174	A:A:R333	A:A:V301	3.92	No	No	0	5	7
175	A:A:V301	A:A:V334	4.81	No	No	0	7	4
176	A:A:D331	A:A:L302	4.07	No	No	24	4	2
177	A:A:L302	A:A:R333	4.86	No	No	24	2	5
178	A:A:L302	A:A:V334	4.47	No	No	0	2	4
179	A:A:A303	A:A:K305	4.82	No	No	0	5	3
180	A:A:E309	A:A:K307	6.75	No	No	0	4	6
181	A:A:D310	A:A:K307	9.68	No	No	0	3	6
182	A:A:F312	A:A:I308	3.77	Yes	No	0	8	7
183	A:A:F315	A:A:I308	12.56	Yes	No	0	6	7
184	A:A:E309	A:A:F315	7	No	Yes	0	4	6
185	A:A:E314	A:A:F312	7	Yes	Yes	13	6	8
186	A:A:F312	A:A:F340	6.43	Yes	Yes	13	8	7
187	A:A:E344	A:A:F312	3.5	Yes	Yes	13	5	8
188	A:A:E314	A:A:P313	4.72	Yes	No	0	6	6
189	A:A:E314	A:A:R317	4.65	Yes	No	0	6	2
190	A:A:E314	A:A:F340	5.83	Yes	Yes	13	6	7
191	A:A:E314	A:A:E344	6.34	Yes	Yes	13	6	5
192	A:A:F315	A:A:Y318	3.09	Yes	Yes	13	6	6
193	A:A:F315	A:A:R336	17.1	Yes	No	13	6	5
194	A:A:F315	A:A:F340	18.22	Yes	Yes	13	6	7
195	A:A:P321	A:A:Y318	5.56	Yes	Yes	0	5	6
196	A:A:R336	A:A:Y318	4.12	No	Yes	13	5	6
197	A:A:F340	A:A:Y318	14.44	Yes	Yes	13	7	6
198	A:A:D343	A:A:Y318	11.49	No	Yes	0	3	6
199	A:A:P321	A:A:T320	5.25	Yes	No	0	5	1
200	A:A:R336	A:A:T320	3.88	No	No	0	5	1
201	A:A:D323	A:A:P321	3.22	No	Yes	0	4	5
202	A:A:P321	A:A:Y339	5.56	Yes	Yes	0	5	3
203	A:A:A324	A:A:Y339	8.01	No	Yes	0	3	3
204	A:A:E330	A:A:P326	6.29	Yes	No	2	3	1
205	A:A:P326	A:A:T335	6.99	No	No	2	1	4
206	A:A:E327	A:A:E330	11.42	No	Yes	0	4	3
207	A:A:E330	A:A:T335	7.06	Yes	No	2	3	4
208	A:A:E330	A:A:K338	5.4	Yes	Yes	2	3	5
209	A:A:D331	A:A:P332	9.66	No	No	0	4	1
210	A:A:D331	A:A:R333	11.91	No	No	24	4	5
211	A:A:K338	A:A:Y339	4.78	Yes	Yes	2	5	3
212	A:A:F363	A:A:K338	17.37	Yes	Yes	2	5	5
213	A:A:R342	A:A:Y339	7.2	Yes	Yes	2	4	3
214	A:A:F363	A:A:Y339	8.25	Yes	Yes	2	5	3
215	A:A:E344	A:A:F340	13.99	Yes	Yes	13	5	7
216	A:A:D343	A:A:R342	4.76	No	Yes	0	3	4
217	A:A:L346	A:A:R342	4.86	No	Yes	2	4	4
218	A:A:P361	A:A:R342	7.21	No	Yes	2	5	4
219	A:A:F363	A:A:R342	8.55	Yes	Yes	2	5	4
220	A:A:D343	R:R:R396	9.53	No	No	0	3	5
221	A:A:E344	A:A:R347	6.98	Yes	No	0	5	4
222	A:A:L346	A:A:S349	3	No	Yes	2	4	7
223	A:A:L346	A:A:P361	3.28	No	No	2	4	5
224	A:A:C359	A:A:S349	5.16	No	Yes	2	5	7
225	A:A:T350	R:R:N393	4.39	No	No	0	4	7
226	A:A:G353	A:A:R356	4.5	No	Yes	2	4	2
227	A:A:G353	A:A:H357	3.18	No	No	2	4	7
228	A:A:G355	A:A:Y358	5.79	No	Yes	0	2	4
229	A:A:H357	A:A:R356	9.03	No	Yes	2	7	2
230	A:A:R385	A:A:Y358	8.23	Yes	Yes	11	5	4
231	A:A:R389	A:A:Y358	5.14	No	Yes	11	4	4
232	A:A:Y358	R:R:T392	4.99	Yes	Yes	11	4	7
233	A:A:Y358	R:R:N393	8.14	Yes	No	11	4	7
234	A:A:D378	A:A:Y360	17.24	No	No	0	7	8
235	A:A:D381	A:A:Y360	13.79	No	No	0	8	8
236	A:A:I382	A:A:Y360	6.04	No	No	0	6	8
237	A:A:H362	A:A:R374	16.93	No	No	0	9	4
238	A:A:D378	A:A:H362	8.82	No	No	0	7	9
239	A:A:N371	A:A:T364	7.31	Yes	No	23	9	9
240	A:A:D368	A:A:E370	5.2	No	No	0	9	4
241	A:A:D368	A:A:N371	13.46	No	Yes	0	9	9
242	A:A:D368	A:A:R374	7.15	No	No	0	9	4
243	A:A:E370	A:A:T369	4.23	No	No	0	4	9
244	A:A:F376	A:A:R373	3.21	Yes	Yes	10	8	5
245	A:A:N377	A:A:R373	8.44	No	Yes	10	4	5
246	A:A:F376	A:A:N377	3.62	Yes	No	10	8	4
247	A:A:F376	R:R:F314	7.5	Yes	Yes	10	8	7
248	A:A:Q384	A:A:R380	8.18	No	No	0	6	7
249	A:A:R380	R:R:F314	7.48	No	Yes	0	7	7
250	A:A:D381	A:A:R385	15.48	No	Yes	11	8	5
251	A:A:D381	R:R:K388	6.91	No	Yes	11	8	9
252	A:A:H387	A:A:I383	3.98	No	No	0	8	8
253	A:A:Q384	R:R:I310	4.12	No	No	0	6	8
254	A:A:Q384	R:R:K388	9.49	No	Yes	0	6	9
255	A:A:R385	A:A:R389	4.26	Yes	No	11	5	4
256	A:A:L394	A:A:R385	3.64	No	Yes	11	8	5
257	A:A:R385	R:R:K388	6.19	Yes	Yes	11	5	9
258	A:A:R385	R:R:T392	6.47	Yes	Yes	11	5	7
259	A:A:H387	A:A:M386	7.88	No	No	0	8	3
260	A:A:M386	A:A:Q390	8.16	No	No	0	3	4
261	A:A:H387	R:R:L309	11.57	No	No	0	8	8
262	A:A:L388	A:A:L394	4.15	No	No	0	8	8
263	A:A:L393	A:A:Y391	5.86	No	Yes	0	8	4
264	A:A:Y391	R:R:R219	7.2	Yes	Yes	6	4	9
265	A:A:Y391	R:R:L306	9.38	Yes	No	0	4	9
266	A:A:Y391	W:W:?1	4.97	Yes	Yes	6	4	0
267	A:A:E392	R:R:G464	4.91	No	No	0	6	7
268	A:A:E392	W:W:?1	5.62	No	Yes	0	6	0
269	A:A:L393	R:R:S409	4.5	No	No	0	8	9
270	A:A:L393	R:R:L413	5.54	No	No	0	8	9
271	A:A:L394	R:R:K388	4.23	No	Yes	11	8	9
272	B:B:E3	B:B:L7	5.3	No	Yes	0	5	8
273	B:B:D5	B:B:Q9	6.53	No	No	0	1	3
274	B:B:E10	B:B:Q6	10.19	No	No	0	8	1
275	B:B:E10	B:B:L7	3.98	No	Yes	0	8	8
276	B:B:L14	B:B:Q17	6.65	No	No	0	8	4
277	B:B:I18	B:B:R22	7.52	No	Yes	0	7	6
278	B:B:I18	G:G:A23	3.25	No	No	0	7	8
279	B:B:D258	B:B:R22	9.53	Yes	Yes	3	7	6
280	B:B:Q259	B:B:R22	4.67	Yes	Yes	0	6	6
281	B:B:R22	G:G:R27	6.4	Yes	Yes	3	6	8
282	B:B:C25	B:B:Q259	3.05	No	Yes	0	3	6
283	B:B:A26	B:B:Q259	4.55	No	Yes	0	3	6
284	B:B:A28	B:B:D27	3.09	No	No	0	4	8
285	B:B:D27	G:G:K29	6.91	No	No	0	8	4
286	B:B:D27	G:G:S31	8.83	No	No	0	8	9
287	B:B:A28	B:B:Q32	3.03	No	No	0	4	1
288	B:B:Q32	B:B:T29	7.09	No	No	0	1	3
289	B:B:L30	B:B:T34	4.42	No	Yes	0	5	5
290	B:B:L30	B:B:M262	9.9	No	Yes	0	5	4
291	B:B:M262	B:B:S31	3.07	Yes	No	0	4	1
292	B:B:I33	G:G:A34	3.25	No	No	0	3	6
293	B:B:I37	B:B:T34	4.56	Yes	Yes	16	2	5
294	B:B:L300	B:B:T34	7.37	No	Yes	0	6	5
295	B:B:T34	G:G:M38	4.52	Yes	No	16	5	4
296	B:B:N35	B:B:N36	9.54	No	No	0	1	1
297	B:B:I37	B:B:R283	5.01	Yes	Yes	16	2	9
298	B:B:I37	G:G:M38	4.37	Yes	No	16	2	4
299	B:B:R283	B:B:V40	7.85	Yes	No	16	9	3
300	B:B:D298	B:B:V40	10.22	No	No	16	9	3
301	B:B:A305	B:B:I43	3.25	No	No	0	4	3
302	B:B:L308	B:B:M45	4.24	No	No	0	7	4
303	B:B:M45	G:G:L50	5.65	No	No	0	4	9
304	B:B:R46	B:B:R48	7.46	No	Yes	0	5	7
305	B:B:K337	B:B:T47	6.01	Yes	No	9	6	3
306	B:B:T47	B:B:W339	8.49	No	Yes	9	3	9
307	B:B:N340	B:B:R48	6.03	No	Yes	0	9	7
308	B:B:R48	G:G:F61	6.41	Yes	Yes	0	7	8
309	B:B:R48	G:G:R62	12.79	Yes	No	0	7	7
310	B:B:R49	G:G:F61	8.55	No	Yes	0	7	8
311	B:B:R52	B:B:T50	9.06	No	No	0	7	3
312	B:B:K337	B:B:T50	7.51	Yes	No	0	6	3
313	B:B:L51	B:B:W82	19.36	No	Yes	0	9	9
314	B:B:L51	B:B:T87	4.42	No	No	0	9	5
315	B:B:L336	B:B:L51	6.92	No	No	0	7	9
316	B:B:F335	B:B:R52	11.76	No	No	0	4	7
317	B:B:H54	B:B:I58	11.93	Yes	No	0	9	9
318	B:B:H54	B:B:S72	8.37	Yes	No	7	9	9
319	B:B:H54	B:B:S74	11.16	Yes	No	0	9	9
320	B:B:H54	B:B:I80	13.26	Yes	No	7	9	8
321	B:B:H54	B:B:W82	6.35	Yes	Yes	7	9	9
322	B:B:D76	B:B:L55	6.79	Yes	No	22	9	6
323	B:B:A56	B:B:D76	4.63	No	Yes	0	7	9
324	B:B:K57	B:B:Q75	13.56	Yes	Yes	0	9	9
325	B:B:K57	B:B:W332	17.4	Yes	Yes	5	9	9
326	B:B:Q75	B:B:Y59	3.38	Yes	No	0	9	8
327	B:B:M101	B:B:Y59	10.78	Yes	No	0	9	8
328	B:B:M61	B:B:W63	5.82	No	Yes	0	6	7
329	B:B:C317	B:B:M61	4.86	No	No	0	7	6
330	B:B:G319	B:B:M61	3.49	No	No	0	5	6
331	B:B:H62	B:B:R150	18.05	No	No	0	6	6
332	B:B:L70	B:B:W63	15.94	No	Yes	8	5	7
333	B:B:S84	B:B:W63	7.41	No	Yes	8	5	7
334	B:B:T321	B:B:W63	9.7	No	Yes	8	7	7
335	B:B:A328	B:B:W63	3.89	No	Yes	0	5	7
336	B:B:G64	B:B:Y105	4.35	No	No	0	5	6
337	B:B:D66	B:B:R68	3.57	No	No	0	8	5
338	B:B:D66	B:B:L69	8.14	No	No	0	8	5
339	B:B:S67	B:B:T321	9.59	No	No	8	5	7
340	B:B:D323	B:B:S67	10.31	No	No	8	7	5
341	B:B:D83	B:B:R68	17.87	Yes	No	0	8	5
342	B:B:R68	B:B:Y85	25.72	No	No	0	5	4
343	B:B:D83	B:B:L69	4.07	Yes	No	0	8	5
344	B:B:L70	B:B:S84	4.5	No	No	8	5	5
345	B:B:L79	B:B:V71	4.47	Yes	Yes	0	7	8
346	B:B:I81	B:B:V71	3.07	No	Yes	0	7	8
347	B:B:C103	B:B:V71	5.12	No	Yes	0	8	8
348	B:B:V112	B:B:V71	3.21	No	Yes	0	8	8
349	B:B:S72	B:B:W82	7.41	No	Yes	7	9	9
350	B:B:L336	B:B:S72	3	No	No	0	7	9
351	B:B:A73	B:B:V100	3.39	No	No	0	9	9
352	B:B:A73	B:B:C103	3.61	No	No	0	9	8
353	B:B:D76	B:B:S74	8.83	Yes	No	0	9	9
354	B:B:Q75	B:B:W99	6.57	Yes	Yes	0	9	9
355	B:B:D76	B:B:K78	6.91	Yes	No	0	9	8
356	B:B:G77	B:B:L95	5.13	No	Yes	0	8	8
357	B:B:I93	B:B:L79	5.71	Yes	Yes	0	7	7
358	B:B:L79	B:B:L95	5.54	Yes	Yes	12	7	8
359	B:B:C114	B:B:L79	6.35	Yes	Yes	12	8	7
360	B:B:I80	B:B:W82	14.09	No	Yes	7	8	9
361	B:B:I80	B:B:K89	5.82	No	Yes	7	8	9
362	B:B:I81	B:B:V90	3.07	No	No	25	7	5
363	B:B:H91	B:B:I81	3.98	No	No	25	5	7
364	B:B:K89	B:B:W82	12.76	Yes	Yes	7	9	9
365	B:B:D83	B:B:T86	7.23	Yes	No	7	8	6
366	B:B:S84	G:G:F61	5.28	No	Yes	8	5	8
367	B:B:Y85	G:G:P60	11.13	No	Yes	8	4	9
368	B:B:Y85	G:G:F61	5.16	No	Yes	8	4	8
369	B:B:N88	B:B:T86	7.31	Yes	No	7	7	6
370	B:B:H91	B:B:V90	5.54	No	No	25	5	5
371	B:B:H91	B:B:V133	8.3	No	No	0	5	4
372	B:B:I93	B:B:P94	3.39	Yes	No	0	7	5
373	B:B:I93	B:B:Y124	8.46	Yes	Yes	0	7	6
374	B:B:I93	B:B:V133	6.14	Yes	No	0	7	4
375	B:B:L95	B:B:V100	4.47	Yes	No	12	8	9
376	B:B:C114	B:B:L95	4.76	Yes	Yes	12	8	8
377	B:B:L95	B:B:Y124	5.86	Yes	Yes	12	8	6
378	B:B:E138	B:B:R96	13.96	Yes	No	0	6	6
379	B:B:D118	B:B:S97	7.36	No	No	0	9	8
380	B:B:S98	B:B:W99	7.41	No	Yes	0	8	9
381	B:B:L117	B:B:W99	4.56	No	Yes	0	9	9
382	B:B:C114	B:B:V100	3.42	Yes	No	12	8	9
383	B:B:G116	B:B:M101	5.24	No	Yes	0	9	9
384	B:B:M101	B:B:Y145	8.38	Yes	Yes	0	9	8
385	B:B:C148	B:B:T102	3.38	Yes	No	0	6	8
386	B:B:G109	B:B:Y105	7.24	No	No	0	5	6
387	B:B:V112	B:B:Y105	3.79	No	No	0	8	6
388	B:B:A106	B:B:F151	8.32	No	Yes	0	6	9
389	B:B:N110	B:B:S108	7.45	No	No	0	4	6
390	B:B:D154	B:B:S108	8.83	No	No	0	6	6
391	B:B:N110	B:B:Y111	3.49	No	Yes	0	4	4
392	B:B:K127	B:B:N110	5.6	No	No	0	4	4
393	B:B:I123	B:B:Y111	3.63	Yes	Yes	1	6	4
394	B:B:N125	B:B:Y111	6.98	No	Yes	0	4	4
395	B:B:F151	B:B:Y111	4.13	Yes	Yes	1	9	4
396	B:B:D154	B:B:Y111	8.05	No	Yes	0	6	4
397	B:B:L126	B:B:V112	4.47	No	No	0	5	8
398	B:B:A113	B:B:F151	4.16	No	Yes	0	9	9
399	B:B:C114	B:B:Y124	5.38	Yes	Yes	12	8	6
400	B:B:G115	B:B:L146	5.13	No	Yes	0	9	7
401	B:B:D118	B:B:I120	7	No	No	0	9	6
402	B:B:I120	B:B:S122	3.1	No	No	12	6	8
403	B:B:E138	B:B:I120	4.1	Yes	No	12	6	6
404	B:B:C121	B:B:L146	4.76	No	Yes	1	8	7
405	B:B:C121	B:B:C149	7.28	No	Yes	1	8	8
406	B:B:C121	B:B:I157	3.27	No	Yes	1	8	7
407	B:B:S122	B:B:Y124	3.82	No	Yes	12	8	6
408	B:B:E138	B:B:S122	5.75	Yes	No	12	6	8
409	B:B:I123	B:B:S136	3.1	Yes	No	0	6	4
410	B:B:I123	B:B:L139	4.28	Yes	No	0	6	9
411	B:B:F151	B:B:I123	3.77	Yes	Yes	1	9	6
412	B:B:I123	B:B:I171	5.89	Yes	No	0	6	6
413	B:B:V135	B:B:Y124	7.57	No	Yes	0	4	6
414	B:B:N125	B:B:T128	4.39	No	No	0	4	3
415	B:B:K127	B:B:L126	4.23	No	No	0	4	5
416	B:B:E130	B:B:T128	14.11	Yes	No	0	3	3
417	B:B:E130	B:B:R129	6.98	Yes	No	0	3	3
418	B:B:E130	B:B:N132	6.57	Yes	No	0	3	3
419	B:B:E130	B:B:R134	3.49	Yes	No	0	3	3
420	B:B:E138	B:B:V135	4.28	Yes	No	0	6	4
421	B:B:G174	B:B:R137	4.5	No	No	0	4	5
422	B:B:L139	B:B:W169	12.53	No	Yes	0	9	8
423	B:B:H142	B:B:T159	6.85	Yes	Yes	1	9	9
424	B:B:H142	B:B:S161	15.34	Yes	No	1	9	9
425	B:B:D163	B:B:H142	8.82	Yes	Yes	1	9	9
426	B:B:H142	B:B:W169	4.23	Yes	Yes	1	9	8
427	B:B:D163	B:B:T143	7.23	Yes	No	0	9	5
428	B:B:D163	B:B:G144	3.35	Yes	No	0	9	8
429	B:B:G162	B:B:Y145	10.14	No	Yes	1	9	8
430	B:B:D186	B:B:Y145	10.34	Yes	Yes	1	9	8
431	B:B:M188	B:B:Y145	7.18	No	Yes	1	8	8
432	B:B:C149	B:B:L146	6.35	Yes	Yes	1	8	7
433	B:B:L146	B:B:T159	4.42	Yes	Yes	1	7	9
434	B:B:C148	B:B:R150	4.18	Yes	No	0	6	6
435	B:B:C148	B:B:S160	3.44	Yes	Yes	4	6	6
436	B:B:C148	B:B:L190	3.17	Yes	No	4	6	5
437	B:B:C149	B:B:I157	4.91	Yes	Yes	1	8	7
438	B:B:C149	B:B:T159	3.38	Yes	Yes	1	8	9
439	B:B:F151	B:B:I157	6.28	Yes	Yes	1	9	7
440	B:B:L152	B:B:Q156	5.32	Yes	No	0	3	5
441	B:B:L152	B:B:V158	4.47	Yes	No	0	3	5
442	B:B:L152	B:B:L192	5.54	Yes	No	0	3	5
443	B:B:D170	B:B:N155	5.39	No	No	0	9	3
444	B:B:E172	B:B:N155	5.26	No	No	0	6	3
445	B:B:L168	B:B:Q156	5.32	No	No	0	6	5
446	B:B:I157	B:B:I171	4.42	Yes	No	0	7	6
447	B:B:F199	B:B:V158	3.93	Yes	No	0	9	5
448	B:B:T159	B:B:W169	10.92	Yes	Yes	1	9	8
449	B:B:C166	B:B:S160	3.44	No	Yes	0	8	6
450	B:B:S160	B:B:V187	6.46	Yes	Yes	4	6	9
451	B:B:L190	B:B:S160	7.51	No	Yes	4	5	6
452	B:B:G162	B:B:S161	3.71	No	No	1	9	9
453	B:B:D163	B:B:S161	10.31	Yes	No	1	9	9
454	B:B:D186	B:B:G162	6.71	Yes	No	1	9	9
455	B:B:D163	B:B:T165	7.23	Yes	No	0	9	7
456	B:B:T165	B:B:T181	3.14	No	No	0	7	2
457	B:B:C166	B:B:F180	4.19	No	Yes	0	8	7
458	B:B:C166	B:B:S201	3.44	No	Yes	0	8	9
459	B:B:A167	B:B:W169	3.89	No	Yes	1	4	8
460	B:B:A167	B:B:Q176	6.06	No	Yes	1	4	4
461	B:B:L168	B:B:T177	4.42	No	No	4	6	4
462	B:B:L168	B:B:T178	5.9	No	No	4	6	4
463	B:B:Q176	B:B:W169	15.33	Yes	Yes	1	4	8
464	B:B:D170	B:B:T173	8.67	No	No	0	9	5
465	B:B:G174	B:B:T173	3.64	No	No	0	4	5
466	B:B:Q176	B:B:T179	7.09	Yes	No	0	4	4
467	B:B:T177	B:B:T178	4.71	No	No	4	4	4
468	B:B:F180	B:B:T178	7.78	Yes	No	4	7	4
469	B:B:F180	B:B:F199	11.79	Yes	Yes	4	7	9
470	B:B:F180	B:B:W211	12.03	Yes	Yes	4	7	8
471	B:B:F180	B:B:G216	3.01	Yes	No	0	7	4
472	B:B:G182	B:B:T181	3.64	No	No	0	6	2
473	B:B:H183	B:B:V187	4.15	Yes	Yes	4	9	9
474	B:B:H183	B:B:S201	5.58	Yes	Yes	4	9	9
475	B:B:A203	B:B:H183	8.78	No	Yes	4	8	9
476	B:B:D205	B:B:H183	6.3	Yes	Yes	4	9	9
477	B:B:H183	B:B:K209	17.03	Yes	Yes	4	9	6
478	B:B:H183	B:B:W211	4.23	Yes	Yes	4	9	8
479	B:B:D205	B:B:T184	5.78	Yes	No	0	9	3
480	B:B:C204	B:B:D186	3.11	Yes	Yes	1	7	9
481	B:B:S201	B:B:V187	3.23	Yes	Yes	4	9	9
482	B:B:A203	B:B:V187	3.39	No	Yes	4	8	9
483	B:B:C204	B:B:M188	3.24	Yes	No	1	7	8
484	B:B:I232	B:B:S189	6.19	Yes	No	0	8	7
485	B:B:F199	B:B:L190	4.87	Yes	No	4	9	5
486	B:B:F234	B:B:S191	5.28	No	No	0	5	8
487	B:B:A193	B:B:D195	3.09	No	No	0	4	5
488	B:B:A193	B:B:F234	5.55	No	No	0	4	5
489	B:B:G238	B:B:P194	4.06	No	No	0	7	4
490	B:B:D195	B:B:R197	9.53	No	No	0	5	5
491	B:B:R197	B:B:R214	15.99	No	No	0	5	9
492	B:B:L198	B:B:L210	4.15	No	Yes	0	3	5
493	B:B:D212	B:B:L198	4.07	No	No	0	9	3
494	B:B:F199	B:B:W211	13.03	Yes	Yes	4	9	8
495	B:B:I232	B:B:V200	6.14	Yes	No	3	8	6
496	B:B:F234	B:B:V200	10.49	No	No	0	5	6
497	B:B:F241	B:B:V200	9.18	Yes	No	3	6	6
498	B:B:S201	B:B:W211	7.41	Yes	Yes	4	9	8
499	B:B:G202	B:B:I229	3.53	No	No	0	6	7
500	B:B:A203	B:B:D205	3.09	No	Yes	4	8	9
501	B:B:C204	B:B:D228	12.45	Yes	Yes	1	7	9
502	B:B:D205	B:B:S207	8.83	Yes	No	0	9	5
503	B:B:S207	B:B:T221	3.2	No	No	0	5	7
504	B:B:K209	B:B:W211	8.12	Yes	Yes	4	6	8
505	B:B:C218	B:B:K209	6.47	No	Yes	4	5	6
506	B:B:K209	B:B:T221	9.01	Yes	No	0	6	7
507	B:B:L210	B:B:R219	6.07	Yes	No	0	5	5
508	B:B:L210	B:B:Q220	7.99	Yes	Yes	0	5	7
509	B:B:L210	B:B:L255	5.54	Yes	No	0	5	6
510	B:B:C218	B:B:W211	3.92	No	Yes	4	5	8
511	B:B:D212	B:B:E215	18.19	No	No	26	9	3
512	B:B:D212	B:B:R219	13.1	No	No	26	9	5
513	B:B:E215	B:B:R219	5.82	No	No	26	3	5
514	B:B:C218	G:G:Q18	4.58	No	No	0	5	9
515	B:B:F222	B:B:Q220	7.03	Yes	Yes	3	8	7
516	B:B:D258	B:B:Q220	9.14	Yes	Yes	3	7	7
517	B:B:Q220	G:G:I25	4.12	Yes	No	0	7	2
518	B:B:T221	G:G:E22	8.47	No	No	0	7	9
519	B:B:F222	B:B:F241	11.79	Yes	Yes	3	8	6
520	B:B:F222	B:B:F253	10.72	Yes	Yes	3	8	6
521	B:B:D258	B:B:F222	5.97	Yes	Yes	3	7	8
522	B:B:H225	B:B:I229	9.28	Yes	No	3	9	7
523	B:B:H225	B:B:T243	6.85	Yes	Yes	3	9	8
524	B:B:H225	B:B:S245	16.74	Yes	No	3	9	9
525	B:B:D247	B:B:H225	5.04	Yes	Yes	3	9	9
526	B:B:H225	B:B:R251	14.67	Yes	Yes	3	9	8
527	B:B:D247	B:B:E226	12.99	Yes	No	0	9	3
528	B:B:D228	B:B:S227	4.42	Yes	No	0	9	6
529	B:B:D246	B:B:S227	5.89	No	No	0	9	6
530	B:B:D247	B:B:S227	4.42	Yes	No	0	9	6
531	B:B:I229	B:B:T243	3.04	No	Yes	3	7	8
532	B:B:D246	B:B:N230	6.73	No	No	1	9	9
533	B:B:A231	B:B:V276	5.09	No	No	0	5	6
534	B:B:F241	B:B:I232	5.02	Yes	Yes	3	6	8
535	B:B:I232	B:B:T243	4.56	Yes	Yes	3	8	8
536	B:B:F235	B:B:P236	10.11	Yes	Yes	20	6	7
537	B:B:F235	B:B:N237	6.04	Yes	Yes	0	6	5
538	B:B:F235	B:B:F278	9.65	Yes	Yes	20	6	7
539	B:B:F235	B:B:G282	4.52	Yes	No	20	6	9
540	B:B:F278	B:B:P236	4.33	Yes	Yes	20	7	7
541	B:B:G282	B:B:P236	4.06	No	Yes	20	9	7
542	B:B:P236	G:G:Y40	5.56	Yes	No	0	7	6
543	B:B:G238	B:B:N237	3.39	No	Yes	0	7	5
544	B:B:N237	B:B:N239	9.54	Yes	No	0	5	2
545	B:B:N237	G:G:Y40	6.98	Yes	No	0	5	6
546	B:B:N239	B:B:R256	7.23	No	No	0	2	9
547	B:B:F241	B:B:F253	8.57	Yes	Yes	3	6	6
548	B:B:A242	B:B:L285	3.15	No	No	0	4	6
549	B:B:F253	B:B:T243	7.78	Yes	Yes	3	6	8
550	B:B:G244	B:B:I273	5.29	No	No	0	5	6
551	B:B:D247	B:B:S245	8.83	Yes	No	3	9	9
552	B:B:D247	B:B:T249	7.23	Yes	No	0	9	6
553	B:B:R251	B:B:T249	9.06	Yes	No	0	8	6
554	B:B:S265	B:B:T249	4.8	No	No	0	2	6
555	B:B:C250	B:B:Y264	4.03	No	Yes	0	8	5
556	B:B:C250	B:B:I273	4.91	No	No	0	8	6
557	B:B:F253	B:B:R251	4.28	Yes	Yes	3	6	8
558	B:B:E260	B:B:R251	15.12	Yes	Yes	3	6	8
559	B:B:R251	B:B:T263	11.64	Yes	No	3	8	1
560	B:B:L252	B:B:L261	6.92	No	No	0	7	5
561	B:B:L252	B:B:Y264	7.03	No	Yes	0	7	5
562	B:B:E260	B:B:F253	7	Yes	Yes	3	6	6
563	B:B:A257	B:B:D254	4.63	No	No	0	7	9
564	B:B:D254	B:B:L261	6.79	No	No	0	9	5
565	B:B:D254	G:G:A33	3.09	No	No	0	9	7
566	B:B:R256	G:G:I28	8.77	No	No	0	9	4
567	B:B:R256	G:G:D36	9.53	No	No	0	9	5
568	B:B:D258	G:G:R27	9.53	Yes	Yes	3	7	8
569	B:B:Q259	G:G:V30	5.73	Yes	No	0	6	8
570	B:B:E260	B:B:T263	7.06	Yes	No	3	6	1
571	B:B:M262	B:B:Y264	9.58	Yes	Yes	0	4	5
572	B:B:A302	B:B:M262	4.83	No	Yes	0	2	4
573	B:B:S265	B:B:T263	3.2	No	No	0	2	1
574	B:B:L285	B:B:Y264	7.03	No	Yes	0	6	5
575	B:B:W297	B:B:Y264	9.65	No	Yes	0	8	5
576	B:B:H266	B:B:N268	6.38	No	No	0	4	4
577	B:B:H266	B:B:R304	6.77	No	No	0	4	5
578	B:B:I269	B:B:Y289	6.04	No	Yes	0	4	7
579	B:B:I269	B:B:R304	6.26	No	No	0	4	5
580	B:B:C271	B:B:Y289	4.03	No	Yes	5	5	7
581	B:B:C271	B:B:D290	3.11	No	Yes	5	5	6
582	B:B:C271	B:B:D291	7.78	No	No	5	5	8
583	B:B:D290	B:B:G272	5.03	Yes	No	0	6	4
584	B:B:I273	B:B:Y289	9.67	No	Yes	0	6	7
585	B:B:S275	B:B:T274	4.8	No	No	0	8	8
586	B:B:R314	B:B:T274	5.17	Yes	No	0	8	8
587	B:B:T274	B:B:V315	3.17	No	Yes	0	8	7
588	B:B:L318	B:B:S275	9.01	No	No	0	6	8
589	B:B:S277	B:B:V320	4.85	No	No	0	5	7
590	B:B:F278	B:B:G282	3.01	Yes	No	20	7	9
591	B:B:F278	B:B:L285	13.4	Yes	No	0	7	6
592	B:B:L284	B:B:S279	4.5	No	No	0	5	9
593	B:B:S279	G:G:D48	8.83	No	Yes	0	9	9
594	B:B:G324	B:B:K280	3.49	No	No	0	9	1
595	B:B:S281	G:G:C41	3.44	No	No	0	9	7
596	B:B:S281	G:G:D48	5.89	No	Yes	0	9	9
597	B:B:D298	B:B:R283	13.1	No	Yes	16	9	9
598	B:B:L300	B:B:R283	8.5	No	Yes	0	6	9
599	B:B:R283	G:G:L51	4.86	Yes	Yes	0	9	6
600	B:B:L284	B:B:V296	5.96	No	No	0	5	5
601	B:B:L284	G:G:L51	4.15	No	Yes	0	5	6
602	B:B:A287	B:B:Y289	5.34	No	Yes	0	6	7
603	B:B:G288	B:B:V315	3.68	No	Yes	0	7	7
604	B:B:D291	B:B:Y289	3.45	No	Yes	5	8	7
605	B:B:N295	B:B:Y289	15.12	Yes	Yes	5	6	7
606	B:B:W297	B:B:Y289	5.79	No	Yes	5	8	7
607	B:B:D290	B:B:R314	8.34	Yes	Yes	5	6	8
608	B:B:D291	B:B:N293	4.04	No	No	0	8	5
609	B:B:A309	B:B:N293	4.69	No	No	0	3	5
610	B:B:C294	B:B:L308	4.76	No	No	0	5	7
611	B:B:C294	B:B:V315	5.12	No	Yes	9	5	7
612	B:B:C294	B:B:T329	3.38	No	Yes	9	5	8
613	B:B:N295	B:B:W297	4.52	Yes	No	5	6	8
614	B:B:N295	B:B:R304	15.67	Yes	No	0	6	5
615	B:B:A305	B:B:V296	3.39	No	No	0	4	5
616	B:B:D298	B:B:K301	8.3	No	No	0	9	5
617	B:B:L300	G:G:C41	3.17	No	No	0	6	7
618	B:B:D303	B:B:K301	5.53	No	No	0	2	5
619	B:B:L308	B:B:W339	13.67	No	Yes	0	7	9
620	B:B:G310	R:R:R476	3	No	No	0	5	7
621	B:B:H311	B:B:V315	4.15	Yes	Yes	9	9	7
622	B:B:H311	B:B:T329	5.48	Yes	Yes	9	9	8
623	B:B:H311	B:B:S331	12.55	Yes	No	9	9	9
624	B:B:D333	B:B:H311	8.82	Yes	Yes	9	9	9
625	B:B:H311	B:B:K337	9.17	Yes	Yes	9	9	6
626	B:B:D312	B:B:D333	7.98	No	Yes	0	5	9
627	B:B:N313	B:B:W332	6.78	No	Yes	0	7	9
628	B:B:R314	B:B:W332	24.99	Yes	Yes	5	8	9
629	B:B:T329	B:B:V315	4.76	Yes	Yes	9	8	7
630	B:B:C317	B:B:S316	3.44	No	No	0	7	9
631	B:B:S316	B:B:W332	3.71	No	Yes	0	9	9
632	B:B:L318	B:B:T329	4.42	No	Yes	0	6	8
633	B:B:V320	B:B:V327	3.21	No	No	0	7	6
634	B:B:D323	B:B:T321	7.23	No	No	8	7	7
635	B:B:D323	B:B:M325	5.54	No	Yes	8	7	5
636	B:B:M325	G:G:P49	5.03	Yes	No	0	5	7
637	B:B:M325	G:G:N59	5.61	Yes	Yes	8	5	9
638	B:B:M325	G:G:P60	6.71	Yes	Yes	8	5	9
639	B:B:A326	B:B:N340	3.13	No	No	0	7	9
640	B:B:A326	G:G:F61	5.55	No	Yes	0	7	8
641	B:B:T329	B:B:W339	8.49	Yes	Yes	9	8	9
642	B:B:D333	B:B:S331	10.31	Yes	No	9	9	9
643	B:B:D333	B:B:F335	11.94	Yes	No	0	9	4
644	B:B:F335	B:B:S334	5.28	No	No	0	4	4
645	B:B:K337	B:B:W339	5.8	Yes	Yes	9	6	9
646	B:B:I338	G:G:F61	3.77	No	Yes	0	5	8
647	B:B:N340	G:G:N59	10.9	No	Yes	0	9	9
648	G:G:I9	G:G:T6	7.6	No	No	0	2	3
649	G:G:E17	G:G:K14	9.45	No	No	0	6	4
650	G:G:E22	G:G:Q18	6.37	No	No	0	9	9
651	G:G:I25	G:G:R27	6.26	No	Yes	0	2	8
652	G:G:I28	G:G:K32	11.63	No	No	0	4	5
653	G:G:A33	G:G:I28	3.25	No	No	0	7	4
654	G:G:H44	G:G:Y40	21.78	No	No	0	6	6
655	G:G:E47	G:G:H44	3.69	No	No	0	3	6
656	G:G:D48	G:G:P49	3.22	Yes	No	0	9	7
657	G:G:D48	G:G:L51	6.79	Yes	Yes	0	9	6
658	G:G:P49	G:G:V54	3.53	No	No	0	7	6
659	G:G:P55	G:G:V54	3.53	No	No	0	5	6
660	G:G:E58	G:G:P55	3.14	No	No	0	5	5
661	G:G:A56	G:G:R62	8.3	No	No	0	4	7
662	G:G:N59	G:G:P60	6.52	Yes	Yes	8	9	9
663	G:G:F61	G:G:N59	4.83	Yes	Yes	8	8	9
664	G:G:N59	G:G:R62	10.85	Yes	No	0	9	7
665	G:G:F61	G:G:P60	4.33	Yes	Yes	8	8	9
666	R:R:A234	R:R:Y195	4	No	Yes	0	8	7
667	R:R:I237	R:R:Y195	8.46	Yes	Yes	0	7	7
668	R:R:F453	R:R:V197	13.11	Yes	No	0	6	5
669	R:R:G452	R:R:S198	3.71	No	No	0	9	9
670	R:R:L199	R:R:M231	7.07	No	No	0	7	8
671	R:R:F453	R:R:S201	6.61	Yes	No	0	6	8
672	R:R:F227	R:R:L202	3.65	No	No	0	9	9
673	R:R:M231	R:R:T203	3.01	No	No	0	8	3
674	R:R:I208	R:R:V204	3.07	No	No	0	8	5
675	R:R:A205	R:R:F227	4.16	No	No	27	9	9
676	R:R:A205	R:R:C460	3.61	No	No	27	9	9
677	R:R:M224	R:R:V206	4.56	Yes	No	0	5	5
678	R:R:L209	R:R:N220	4.12	No	No	0	7	9
679	R:R:L209	R:R:M224	5.65	No	Yes	0	7	5
680	R:R:F212	R:R:L215	6.09	Yes	Yes	6	7	9
681	R:R:E469	R:R:F212	15.16	Yes	Yes	6	9	7
682	R:R:H216	R:R:R213	14.67	No	No	0	8	8
683	R:R:E469	R:R:R214	6.98	Yes	No	0	9	7
684	R:R:E465	R:R:L215	3.98	Yes	Yes	6	9	9
685	R:R:L215	R:R:V466	5.96	Yes	No	6	9	9
686	R:R:E469	R:R:L215	14.58	Yes	Yes	6	9	9
687	R:R:H216	R:R:Y221	13.07	No	No	0	8	7
688	R:R:T218	R:R:Y305	9.99	No	No	0	7	8
689	R:R:L321	R:R:T218	4.42	No	No	0	6	7
690	R:R:N220	R:R:R219	9.64	No	Yes	6	9	9
691	R:R:H223	R:R:R219	7.9	Yes	Yes	6	9	9
692	R:R:E465	R:R:R219	3.49	Yes	Yes	6	9	9
693	R:R:R219	W:W:?1	3.22	Yes	Yes	6	9	0
694	R:R:H223	R:R:N220	5.1	Yes	No	6	9	9
695	R:R:E302	R:R:I222	6.83	Yes	No	0	9	9
696	R:R:E302	R:R:H223	9.85	Yes	Yes	6	9	9
697	R:R:H223	W:W:?1	8.17	Yes	Yes	6	9	0
698	R:R:H225	R:R:W298	15.87	No	Yes	19	8	9
699	R:R:H225	R:R:W329	8.46	No	Yes	19	8	9
700	R:R:F230	R:R:L226	9.74	Yes	No	0	8	9
701	R:R:E302	R:R:L226	10.6	Yes	No	0	9	9
702	R:R:C460	R:R:F227	4.19	No	No	27	9	9
703	R:R:L228	R:R:L232	4.15	No	No	0	4	8
704	R:R:L228	R:R:W329	5.69	No	Yes	0	4	9
705	R:R:S229	R:R:T294	4.8	No	No	0	9	8
706	R:R:N295	R:R:S229	8.94	No	No	0	8	9
707	R:R:F230	R:R:N295	6.04	Yes	No	0	8	8
708	R:R:F230	R:R:I299	3.77	Yes	No	0	8	9
709	R:R:F230	R:R:F417	4.29	Yes	No	0	8	9
710	R:R:F230	R:R:V455	10.49	Yes	No	0	8	9
711	R:R:F291	R:R:L232	15.83	No	No	0	5	8
712	R:R:I237	R:R:R233	3.76	Yes	Yes	14	7	8
713	R:R:L292	R:R:R233	4.86	No	Yes	0	6	8
714	R:R:N295	R:R:R233	10.85	No	Yes	0	8	8
715	R:R:R233	R:R:Y296	5.14	Yes	Yes	14	8	7
716	R:R:N448	R:R:R233	3.62	No	Yes	14	6	8
717	R:R:Q451	R:R:R233	17.52	No	Yes	0	9	8
718	R:R:F291	R:R:S236	6.61	No	No	0	5	7
719	R:R:I237	R:R:N448	4.25	Yes	No	14	7	6
720	R:R:F238	R:R:V239	3.93	No	No	0	7	5
721	R:R:K240	R:R:L244	4.23	No	No	0	7	5
722	R:R:K240	R:R:V285	4.55	No	No	0	7	6
723	R:R:F288	R:R:K240	17.37	No	No	0	7	7
724	R:R:C281	R:R:R282	4.18	No	No	0	9	8
725	R:R:R282	R:R:R343	6.4	No	No	0	8	8
726	R:R:T286	R:R:V340	3.17	No	No	0	7	5
727	R:R:L289	R:R:W339	6.83	No	Yes	0	7	8
728	R:R:I363	R:R:L289	4.28	No	No	0	7	7
729	R:R:F291	R:R:Y290	9.28	No	Yes	0	5	9
730	R:R:T294	R:R:Y290	8.74	No	Yes	19	8	9
731	R:R:W329	R:R:Y290	5.79	Yes	Yes	19	9	9
732	R:R:A333	R:R:Y290	4	No	Yes	0	5	9
733	R:R:A293	R:R:I367	3.25	No	Yes	0	6	7
734	R:R:T294	R:R:W329	4.85	No	Yes	19	8	9
735	R:R:I367	R:R:Y296	4.84	Yes	Yes	14	7	7
736	R:R:I371	R:R:Y296	3.63	No	Yes	14	7	7
737	R:R:Y296	R:R:Y421	8.94	Yes	Yes	14	7	8
738	R:R:F327	R:R:Y297	3.09	No	Yes	21	5	6
739	R:R:L331	R:R:Y297	4.69	No	Yes	21	4	6
740	R:R:P332	R:R:Y297	6.95	No	Yes	21	9	6
741	R:R:S370	R:R:Y297	7.63	No	Yes	0	7	6
742	R:R:V301	R:R:W298	3.68	No	Yes	0	8	9
743	R:R:G328	R:R:W298	8.44	No	Yes	0	9	9
744	R:R:W298	R:R:W329	21.56	Yes	Yes	19	9	9
745	R:R:I299	W:W:?1	9.07	No	Yes	0	9	0
746	R:R:L300	R:R:S370	7.51	No	No	0	8	7
747	R:R:L300	R:R:L373	6.92	No	No	0	8	7
748	R:R:L300	R:R:N374	4.12	No	No	0	8	9
749	R:R:F324	R:R:V301	5.24	No	No	0	7	8
750	R:R:E302	W:W:?1	12.63	Yes	Yes	6	9	0
751	R:R:L304	R:R:L377	5.54	No	No	0	5	7
752	R:R:L309	R:R:Y305	11.72	No	No	0	8	8
753	R:R:I310	R:R:L306	4.28	No	No	0	8	9
754	R:R:I381	R:R:L306	4.28	No	No	0	9	9
755	R:R:F311	R:R:H307	11.31	No	No	0	6	8
756	R:R:H307	R:R:L377	10.29	No	No	0	8	7
757	R:R:H307	R:R:N380	7.65	No	No	0	8	8
758	R:R:F311	R:R:I310	5.02	No	No	0	6	8
759	R:R:F311	R:R:V384	3.93	No	No	0	6	8
760	R:R:K319	R:R:L321	14.1	No	No	0	6	6
761	R:R:L321	R:R:W322	4.56	No	No	0	6	3
762	R:R:T325	R:R:W322	4.85	No	No	0	5	3
763	R:R:F327	R:R:L331	7.31	No	No	21	5	4
764	R:R:L331	R:R:P332	3.28	No	No	21	4	9
765	R:R:F335	R:R:I363	3.77	No	No	0	5	7
766	R:R:F335	R:R:P366	8.67	No	No	0	5	9
767	R:R:I362	R:R:V338	3.07	No	No	0	8	5
768	R:R:V340	R:R:W339	3.68	No	Yes	0	5	8
769	R:R:I362	R:R:W339	4.7	No	Yes	0	8	8
770	R:R:L346	R:R:T345	8.84	No	No	0	3	3
771	R:R:K360	R:R:W361	9.28	No	No	0	7	8
772	R:R:Q364	R:R:Y421	5.64	No	Yes	0	7	8
773	R:R:P366	R:R:V365	3.53	No	No	0	9	5
774	R:R:L368	R:R:V365	4.47	No	No	0	4	5
775	R:R:I367	R:R:Y421	9.67	Yes	Yes	14	7	8
776	R:R:G418	R:R:I371	5.29	No	No	0	9	7
777	R:R:I371	R:R:Y421	3.63	No	Yes	14	7	8
778	R:R:N374	R:R:P415	3.26	No	No	0	9	9
779	R:R:F375	R:R:F378	3.22	No	Yes	0	7	9
780	R:R:F375	R:R:I379	6.28	No	No	0	7	5
781	R:R:F378	R:R:V382	3.93	Yes	No	0	9	7
782	R:R:F378	R:R:M414	3.73	Yes	No	0	9	8
783	R:R:F378	R:R:P415	7.22	Yes	No	0	9	9
784	R:R:I381	R:R:L413	4.28	No	No	0	9	9
785	R:R:T410	R:R:V382	4.76	No	No	0	9	7
786	R:R:K388	R:R:V384	4.55	Yes	No	0	9	8
787	R:R:L385	R:R:S409	3	No	No	0	8	9
788	R:R:A386	R:R:L406	3.15	No	No	0	6	8
789	R:R:R390	R:R:T387	5.17	No	No	0	6	7
790	R:R:E391	R:R:T387	4.23	No	No	0	7	7
791	R:R:L389	R:R:Q402	7.99	No	No	0	8	6
792	R:R:K405	R:R:L389	4.23	No	No	0	8	8
793	R:R:L389	R:R:L406	4.15	No	No	0	8	8
794	R:R:N393	R:R:T392	7.31	No	Yes	11	7	7
795	R:R:C397	R:R:T392	3.38	No	Yes	0	5	7
796	R:R:C397	R:R:Q402	7.63	No	No	0	5	6
797	R:R:D398	R:R:Q401	3.92	No	No	0	6	6
798	R:R:Q401	R:R:Q402	3.84	No	No	0	6	6
799	R:R:K405	R:R:Q401	4.07	No	No	0	8	6
800	R:R:L407	R:R:R404	3.64	No	No	0	8	6
801	R:R:K408	R:R:R404	4.95	No	No	0	8	6
802	R:R:L411	R:R:M414	5.65	No	No	0	8	8
803	R:R:L416	R:R:M414	7.07	No	No	0	9	8
804	R:R:L416	W:W:?1	7.33	No	Yes	0	9	0
805	R:R:F417	R:R:Q451	4.68	No	No	0	9	9
806	R:R:F417	W:W:?1	12.9	No	Yes	0	9	0
807	R:R:F447	R:R:H420	5.66	No	No	0	5	8
808	R:R:M425	R:R:Y421	4.79	No	Yes	0	6	8
809	R:R:F450	R:R:F453	7.5	No	Yes	0	7	6
810	R:R:F450	R:R:F454	9.65	No	No	0	7	6
811	R:R:G452	R:R:Q451	4.93	No	No	0	9	9
812	R:R:F453	R:R:I457	8.79	Yes	No	0	6	6
813	R:R:F454	R:R:I458	5.02	No	No	0	6	8
814	R:R:F454	W:W:?1	9.03	No	Yes	0	6	0
815	R:R:V455	R:R:Y459	3.79	No	No	0	9	8
816	R:R:Y459	W:W:?1	26.08	No	Yes	0	8	0
817	R:R:E465	R:R:N463	13.15	Yes	No	6	9	9
818	R:R:N463	R:R:V466	5.91	No	No	6	9	9
819	R:R:N463	W:W:?1	9.46	No	Yes	6	9	0
820	R:R:E465	R:R:V466	5.7	Yes	No	6	9	9
821	R:R:W474	R:R:W477	4.69	No	No	0	5	4
822	R:R:T478	R:R:W477	6.06	No	No	0	4	4
823	A:A:L297	A:A:V301	2.98	Yes	No	0	8	7
824	B:B:V327	G:G:L50	2.98	No	No	0	6	9
825	R:R:L368	R:R:V372	2.98	No	No	0	4	4
826	R:R:L416	R:R:V419	2.98	No	No	0	9	7
827	B:B:N293	B:B:V307	2.96	No	No	0	5	3
828	B:B:N295	B:B:V307	2.96	Yes	No	0	6	3
829	B:B:L146	B:B:T102	2.95	Yes	No	0	7	8
830	B:B:L152	B:B:T196	2.95	Yes	No	0	3	1
831	G:G:L51	G:G:T52	2.95	Yes	No	0	6	4
832	R:R:D241	R:R:S246	2.94	No	No	0	8	4
833	R:R:I363	R:R:I367	2.94	No	Yes	0	7	7
834	A:A:N218	A:A:T40	2.92	No	No	0	4	7
835	B:B:I33	G:G:M38	2.92	No	No	0	3	4
836	A:A:I26	B:B:K89	2.91	No	Yes	0	9	9
837	B:B:D322	B:B:T65	2.89	No	No	0	1	1
838	B:B:F151	B:B:P107	2.89	Yes	No	0	9	6
839	B:B:L4	G:G:I9	2.85	No	No	0	4	2
840	B:B:E10	G:G:V16	2.85	No	No	0	8	7
841	B:B:I171	B:B:N155	2.83	No	No	0	6	3
842	B:B:Q175	B:B:T173	2.83	No	No	0	4	5
843	R:R:L202	R:R:M231	2.83	No	No	0	9	8
844	B:B:G310	B:B:W339	2.81	No	Yes	0	5	9
845	A:A:A269	A:A:F345	2.77	No	Yes	0	9	8
846	A:A:A337	A:A:F315	2.77	No	Yes	0	8	6
847	B:B:A21	G:G:R27	2.77	No	Yes	0	4	8
848	B:B:A104	B:B:R150	2.77	No	No	0	7	6
849	B:B:A104	B:B:F151	2.77	No	Yes	0	7	9
850	B:B:A208	B:B:F241	2.77	No	Yes	0	6	6
851	B:B:A240	B:B:F235	2.77	No	Yes	0	6	6
852	B:B:L261	G:G:L37	2.77	No	No	0	5	7
853	B:B:K280	G:G:D48	2.77	No	Yes	0	1	9
854	R:R:A386	R:R:R383	2.77	No	No	0	6	8
855	R:R:L407	R:R:L411	2.77	No	No	0	8	8
856	R:R:H420	R:R:V419	2.77	No	No	0	8	7
857	R:R:H225	R:R:T325	2.74	No	No	0	8	5
858	R:R:K360	R:R:Q364	2.71	No	No	0	7	7
859	B:B:A299	B:B:Y264	2.67	No	Yes	0	5	5
860	B:B:L14	B:B:Q13	2.66	No	No	0	8	1
861	B:B:D153	B:B:D154	2.66	No	No	0	5	6
862	A:A:E299	A:A:L296	2.65	No	Yes	0	6	6
863	B:B:E12	B:B:N16	2.63	No	No	0	4	1
864	B:B:F199	B:B:V213	2.62	Yes	No	0	9	4
865	R:R:R343	R:R:V340	2.62	No	No	0	8	5
866	A:A:D229	A:A:E230	2.6	No	Yes	0	8	9
867	A:A:R42	A:A:T40	2.59	No	No	0	9	7
868	A:A:R356	A:A:T284	2.59	Yes	No	0	2	4
869	B:B:E12	B:B:Q9	2.55	No	No	0	4	3
870	B:B:S147	B:B:Y145	2.54	No	Yes	0	9	8
871	A:A:F212	A:A:I62	2.51	Yes	No	0	9	9
872	R:R:F212	R:R:I208	2.51	Yes	No	0	7	8
873	R:R:F424	R:R:M425	2.49	No	No	0	7	6
874	R:R:K472	R:R:R476	2.48	No	No	0	7	7
875	R:R:V285	R:R:W339	2.45	No	Yes	0	6	8
876	R:R:F230	R:R:L202	2.44	Yes	No	0	8	9
877	A:A:L46	A:A:R231	2.43	No	No	0	8	9
878	B:B:L7	G:G:R13	2.43	Yes	No	0	8	6
879	B:B:F292	B:B:N313	2.42	No	No	0	4	7
880	R:R:M224	R:R:Y221	2.39	Yes	No	0	5	7
881	R:R:D398	R:R:R400	2.38	No	No	0	6	8
882	R:R:I470	R:R:W474	2.35	No	No	0	5	5
883	B:B:R19	B:B:R22	2.13	No	Yes	0	4	6
884	A:A:G206	A:A:G226	2.11	No	No	0	8	9
885	A:A:G225	A:A:G226	2.11	No	No	0	9	9
886	R:R:F238	R:R:Y195	2.06	No	Yes	0	7	7
887	R:R:F212	R:R:Y211	2.06	Yes	No	0	7	2
888	R:R:G330	R:R:P332	2.03	No	No	0	7	9
889	B:B:C204	B:B:G185	1.96	Yes	No	0	7	5
890	B:B:C317	B:B:G330	1.96	No	No	0	7	5
891	B:B:A140	B:B:G141	1.95	No	No	0	5	5
892	B:B:A305	B:B:G306	1.95	No	No	0	4	4
893	R:R:A394	R:R:G395	1.95	No	No	0	5	5
894	B:B:G41	B:B:V40	1.84	No	No	0	1	3
895	B:B:G244	B:B:V276	1.84	No	No	0	5	6
896	R:R:G194	R:R:V193	1.84	No	No	0	9	6
897	R:R:G194	R:R:V197	1.84	No	No	0	9	5
898	B:B:G131	B:B:T128	1.82	No	No	0	4	3
899	B:B:G224	B:B:T223	1.82	No	No	0	6	2
900	B:B:A60	B:B:C103	1.81	No	No	0	7	8
901	G:G:P55	G:G:S57	1.78	No	No	0	5	6
902	A:A:P326	A:A:T325	1.75	No	No	0	1	2
903	B:B:P107	B:B:T65	1.75	No	No	0	6	1
904	G:G:P53	G:G:T52	1.75	No	No	0	8	4
905	B:B:G53	B:B:K89	1.74	No	Yes	0	9	9
906	B:B:C233	B:B:S277	1.72	No	No	0	3	5
907	A:A:A48	A:A:S51	1.71	No	Yes	0	8	9
908	A:A:C365	A:A:V367	1.71	No	No	0	8	9
909	R:R:A456	R:R:S201	1.71	No	No	0	8	8
910	R:R:A242	R:R:S246	1.71	No	No	0	4	4
911	R:R:C281	R:R:V283	1.71	No	No	0	9	4
912	R:R:A313	R:R:S308	1.71	No	No	0	7	7
913	A:A:A372	A:A:V214	1.7	No	No	0	8	6
914	A:A:A298	A:A:V334	1.7	No	No	0	4	4
915	B:B:A11	G:G:V16	1.7	No	No	0	5	7
916	R:R:A284	R:R:V239	1.7	No	No	0	6	5
917	R:R:A284	R:R:V243	1.7	No	No	0	6	5
918	R:R:G303	R:R:N374	1.7	No	No	0	9	9
919	A:A:A366	A:A:T55	1.68	No	No	0	9	9
920	A:A:D354	A:A:G355	1.68	No	No	0	3	2
921	B:B:G141	B:B:Q176	1.64	No	Yes	0	5	4
922	B:B:E260	B:B:G224	1.64	Yes	No	0	6	6
923	R:R:C462	R:R:I457	1.64	No	No	0	6	6
924	R:R:G464	R:R:Q467	1.64	No	No	0	7	8
925	B:B:A28	B:B:I33	1.62	No	No	0	4	3
926	B:B:A248	B:B:I269	1.62	No	No	0	5	4
927	B:B:D38	B:B:P39	1.61	No	No	0	1	1
928	R:R:A210	R:R:M224	1.61	No	Yes	0	4	5
929	A:A:S54	A:A:T55	1.6	No	No	0	9	9
930	G:G:S8	G:G:T6	1.6	No	No	0	4	3
931	A:A:T40	A:A:V36	1.59	No	No	0	7	2
932	R:R:T286	R:R:V336	1.59	No	No	0	7	7
933	R:R:T325	R:R:V326	1.59	No	No	0	5	4
934	B:B:L7	G:G:A12	1.58	Yes	No	0	8	5
935	B:B:A11	G:G:L15	1.58	No	No	0	5	2
936	B:B:A11	G:G:L19	1.58	No	No	0	5	9
937	B:B:L14	G:G:A23	1.58	No	No	0	8	8
938	G:G:A45	G:G:L51	1.58	No	Yes	0	4	6
939	R:R:A313	R:R:L309	1.58	No	No	0	7	8
940	R:R:V412	W:W:?1	1.58	No	Yes	0	8	0
941	A:A:E327	A:A:P328	1.57	No	No	0	4	1
942	A:A:C365	A:A:D295	1.56	No	No	0	8	9
943	G:G:A23	G:G:N24	1.56	No	No	0	8	1
944	A:A:D323	R:R:A394	1.54	No	No	0	4	5
945	B:B:A21	B:B:D20	1.54	No	No	0	4	2
946	R:R:I376	R:R:V372	1.54	No	No	0	4	4
947	A:A:K58	A:A:S54	1.53	No	No	0	9	9
948	A:A:M221	A:A:V57	1.52	No	No	0	8	7
949	G:G:K20	G:G:V16	1.52	No	No	0	6	7
950	A:A:A316	A:A:E309	1.51	No	No	0	2	4
951	B:B:L286	B:B:S277	1.5	No	No	0	7	5
952	R:R:L199	R:R:V235	1.49	No	No	0	7	4
953	R:R:L346	R:R:V342	1.49	No	No	0	3	5
954	B:B:A206	B:B:H225	1.46	No	Yes	0	4	9
955	G:G:A43	G:G:H44	1.46	No	No	0	4	6
956	A:A:K300	A:A:K305	1.44	Yes	No	0	9	3
957	B:B:E3	B:B:S2	1.44	No	No	0	5	5
958	B:B:I18	G:G:L19	1.43	No	No	0	7	9
959	R:R:I422	R:R:L368	1.43	No	No	0	5	4
960	B:B:K15	G:G:L19	1.41	No	No	0	6	9
961	B:B:D38	B:B:I37	1.4	No	Yes	0	1	2
962	R:R:D241	R:R:I237	1.4	No	Yes	0	8	7
963	B:B:L4	B:B:L7	1.38	No	Yes	0	4	8
964	G:G:A10	G:G:R13	1.38	No	No	0	2	6
965	R:R:A386	R:R:R390	1.38	No	No	0	6	6
966	R:R:E469	R:R:I470	1.37	Yes	No	0	9	5
967	G:G:M21	G:G:Q18	1.36	No	No	0	1	9
968	G:G:E47	G:G:K46	1.35	No	No	0	3	1
969	R:R:F315	R:R:S316	1.32	No	No	0	6	7
970	R:R:F287	R:R:V283	1.31	No	No	0	3	4
971	R:R:F335	R:R:V334	1.31	No	No	0	5	4
972	R:R:S449	R:R:Y195	1.27	No	Yes	0	9	7
973	G:G:K14	G:G:R13	1.24	No	No	0	4	6
974	R:R:M445	R:R:Y191	1.2	No	No	0	6	7
975	B:B:Q9	B:B:R8	1.17	No	No	0	3	3
976	B:B:Q44	B:B:R42	1.17	No	No	0	4	2
977	B:B:Q44	B:B:R46	1.17	No	No	0	4	5
978	R:R:L406	R:R:Y403	1.17	No	No	0	8	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	A:A:S51	4.036	5	15	9
2	A:A:K53	5.918	5	15	9
3	A:A:F212	7.7125	4	0	9
4	A:A:F219	7.01167	6	10	8
5	A:A:F222	9.312	5	17	7
6	A:A:Q227	5.98	4	0	9
7	A:A:E230	5.4375	4	1	9
8	A:A:K233	5.62	6	1	9
9	A:A:W234	6.916	5	0	9
10	A:A:F238	9.4725	4	0	9
11	A:A:V247	4.635	4	15	7
12	A:A:D252	9.31	4	18	8
13	A:A:Y253	9.97	4	2	8
14	A:A:R265	11.325	4	18	9
15	A:A:F273	5.00667	6	2	9
16	A:A:W277	10.628	5	2	6
17	A:A:W281	11.5783	6	5	5
18	A:A:L289	5.5825	4	0	9
19	A:A:F290	5.38	5	23	9
20	A:A:Q294	7.0825	4	2	6
21	A:A:L296	4.1675	4	0	6
22	A:A:L297	3.705	4	2	8
23	A:A:K300	8.6625	4	2	9
24	A:A:F312	5.114	5	13	8
25	A:A:E314	5.708	5	13	6
26	A:A:F315	10.1233	6	13	6
27	A:A:Y318	7.74	5	13	6
28	A:A:P321	4.8975	4	0	5
29	A:A:E330	7.5425	4	2	3
30	A:A:K338	8.9225	4	2	5
31	A:A:Y339	6.76	5	2	3
32	A:A:F340	11.782	5	13	7
33	A:A:R342	6.516	5	2	4
34	A:A:E344	6.958	5	13	5
35	A:A:F345	6.346	5	0	8
36	A:A:S349	5.81	4	2	7
37	A:A:R356	7.2275	4	2	2
38	A:A:Y358	6.458	5	11	4
39	A:A:F363	9.672	5	2	5
40	A:A:N371	7.72	4	23	9
41	A:A:R373	6.5725	4	10	5
42	A:A:F376	5.96571	7	10	8
43	A:A:R385	7.37833	6	11	5
44	A:A:Y391	6.8525	4	6	4
45	B:B:L7	2.934	5	0	8
46	B:B:R22	6.05	5	3	6
47	B:B:T34	5.2175	4	16	5
48	B:B:I37	3.835	4	16	2
49	B:B:R48	8.1725	4	0	7
50	B:B:H54	10.214	5	7	9
51	B:B:K57	11.565	4	5	9
52	B:B:W63	8.552	5	8	7
53	B:B:V71	3.9675	4	0	8
54	B:B:Q75	7.0225	4	0	9
55	B:B:D76	6.352	5	22	9
56	B:B:L79	5.5175	4	12	7
57	B:B:W82	11.994	5	7	9
58	B:B:D83	9.5775	4	7	8
59	B:B:N88	9.0975	4	7	7
60	B:B:K89	5.945	6	7	9
61	B:B:I93	5.925	4	0	7
62	B:B:L95	5.152	5	12	8
63	B:B:W99	9.02167	6	17	9
64	B:B:M101	7.315	4	0	9
65	B:B:Y111	5.256	5	1	4
66	B:B:C114	4.9775	4	12	8
67	B:B:I123	4.134	5	1	6
68	B:B:Y124	6.218	5	12	6
69	B:B:E130	7.7875	4	0	3
70	B:B:E138	7.0225	4	12	6
71	B:B:H142	8.81	4	1	9
72	B:B:Y145	6.98857	7	1	8
73	B:B:L146	4.722	5	1	7
74	B:B:C148	3.5425	4	4	6
75	B:B:C149	5.48	4	1	8
76	B:B:F151	4.61714	7	1	9
77	B:B:L152	4.57	4	0	3
78	B:B:I157	4.72	4	1	7
79	B:B:T159	6.3925	4	1	9
80	B:B:S160	5.2125	4	4	6
81	B:B:D163	7.388	5	1	9
82	B:B:W169	9.38	5	1	8
83	B:B:Q176	7.53	4	1	4
84	B:B:F180	7.76	5	4	7
85	B:B:H183	7.67833	6	4	9
86	B:B:D186	6.74	5	1	9
87	B:B:V187	4.3075	4	4	9
88	B:B:F199	7.248	5	4	9
89	B:B:S201	4.915	4	4	9
90	B:B:C204	5.122	5	1	7
91	B:B:D205	6	4	4	9
92	B:B:K209	10.1575	4	4	6
93	B:B:L210	5.9375	4	0	5
94	B:B:W211	8.12333	6	4	8
95	B:B:Q220	7.07	4	3	7
96	B:B:F222	8.8775	4	3	8
97	B:B:H225	9.00667	6	3	9
98	B:B:D228	9.5675	4	1	9
99	B:B:I232	5.4775	4	3	8
100	B:B:F235	6.618	5	20	6
101	B:B:P236	6.015	4	20	7
102	B:B:N237	6.4875	4	0	5
103	B:B:F241	7.466	5	3	6
104	B:B:T243	5.5575	4	3	8
105	B:B:D247	7.702	5	3	9
106	B:B:R251	10.954	5	3	8
107	B:B:F253	7.67	5	3	6
108	B:B:D258	8.5425	4	3	7
109	B:B:Q259	4.5	4	0	6
110	B:B:E260	7.705	4	3	6
111	B:B:M262	6.845	4	0	4
112	B:B:Y264	6.665	6	0	5
113	B:B:F278	7.5975	4	20	7
114	B:B:R283	7.864	5	16	9
115	B:B:Y289	7.06286	7	5	7
116	B:B:D290	6.274	5	5	6
117	B:B:N295	9.5675	4	5	6
118	B:B:H311	8.034	5	9	9
119	B:B:R314	13.198	5	5	8
120	B:B:V315	4.176	5	9	7
121	B:B:M325	5.7225	4	8	5
122	B:B:T329	5.306	5	9	8
123	B:B:W332	11.855	6	5	9
124	B:B:D333	9.7625	4	9	9
125	B:B:K337	7.1225	4	9	6
126	B:B:W339	7.852	5	9	9
127	G:G:R27	6.24	4	3	8
128	G:G:D48	5.5	5	0	9
129	G:G:L51	4.066	5	0	6
130	G:G:N59	7.742	5	8	9
131	G:G:P60	7.1725	4	8	9
132	G:G:F61	5.485	8	8	8
133	R:R:Y195	3.9475	4	0	7
134	R:R:F212	6.455	4	6	7
135	R:R:L215	7.6525	4	6	9
136	R:R:R219	6.29	5	6	9
137	R:R:H223	7.755	4	6	9
138	R:R:M224	3.5525	4	0	5
139	R:R:F230	6.12833	6	0	8
140	R:R:R233	7.625	6	14	8
141	R:R:I237	4.4675	4	14	7
142	R:R:Y290	6.9525	4	19	9
143	R:R:Y296	5.6375	4	14	7
144	R:R:Y297	5.59	4	21	6
145	R:R:W298	12.3875	4	19	9
146	R:R:E302	9.9775	4	6	9
147	R:R:F314	7.3175	4	10	7
148	R:R:W329	9.27	5	19	9
149	R:R:W339	4.415	4	0	8
150	R:R:I367	5.175	4	14	7
151	R:R:F378	4.525	4	0	9
152	R:R:K388	6.274	5	11	9
153	R:R:T392	5.5375	4	11	7
154	R:R:Y421	6.534	5	14	8
155	R:R:F453	9.0025	4	0	6
156	R:R:E465	6.58	4	6	9
157	R:R:E469	9.5225	4	6	9
158	W:W:?1	9.17167	12	6	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	A:A:W281	B:B:W332	89.9879	4.69	Yes	Yes	5	5	9
2	A:A:R280	A:A:W281	90.0507	22.99	No	Yes	5	5	5
3	A:A:R280	A:A:R283	99.8101	5.33	No	No	0	5	3
4	A:A:R283	A:A:R356	99.8482	12.79	No	Yes	0	3	2
5	A:A:H357	A:A:R356	99.8913	9.03	No	Yes	2	7	2
6	A:A:H357	A:A:W277	100	29.62	No	Yes	2	7	6
7	A:A:F273	A:A:W277	59.5483	5.01	Yes	Yes	2	9	6
8	A:A:F273	A:A:F345	39.8292	5.36	Yes	Yes	0	9	8
9	A:A:F345	A:A:L270	20.0273	9.74	Yes	No	0	8	6
10	A:A:E344	A:A:L270	19.969	3.98	Yes	No	0	5	6
11	A:A:E344	A:A:F312	19.5943	3.5	Yes	Yes	13	5	8
12	A:A:F312	A:A:I308	19.5925	3.77	Yes	No	0	8	7
13	A:A:I308	A:A:Y253	19.7933	12.09	No	Yes	0	7	8
14	A:A:K300	A:A:Y253	97.2624	17.91	Yes	Yes	2	9	8
15	A:A:K300	A:A:S251	96.8151	6.12	Yes	No	0	9	9
16	A:A:L296	A:A:S251	96.6613	3	Yes	No	0	6	9
17	A:A:K293	A:A:L296	95.892	4.23	No	Yes	0	9	6
18	A:A:K293	A:A:N292	94.3497	8.39	No	No	0	9	9
19	A:A:F345	A:A:L289	19.7959	7.31	Yes	Yes	0	8	9
20	A:A:L289	A:A:L291	59.2052	6.92	Yes	No	0	9	8
21	A:A:L291	A:A:S250	59.1159	4.5	No	No	0	8	6
22	A:A:L297	A:A:S250	59.0299	3	Yes	No	2	8	6
23	A:A:L297	A:A:Y253	77.8032	3.52	Yes	Yes	2	8	8
24	A:A:C359	A:A:F273	19.7823	4.19	No	Yes	2	5	9
25	A:A:C359	A:A:L289	39.484	3.17	No	Yes	0	5	9
26	A:A:S349	A:A:W277	40.5704	11.12	Yes	Yes	2	7	6
27	A:A:C359	A:A:S349	19.7536	5.16	No	Yes	2	5	7
28	A:A:L346	A:A:S349	20.8155	3	No	Yes	2	4	7
29	A:A:L346	A:A:R342	20.7639	4.86	No	Yes	2	4	4
30	A:A:F363	A:A:R342	19.9635	8.55	Yes	Yes	2	5	4
31	A:A:F363	A:A:Q294	19.7398	10.54	Yes	Yes	2	5	6
32	A:A:L297	A:A:Q294	19.846	5.32	Yes	Yes	2	8	6
33	A:A:N292	A:A:T364	88.0409	4.39	No	No	0	9	9
34	A:A:K233	B:B:Y145	59.0917	3.58	Yes	Yes	1	9	8
35	A:A:K233	B:B:D228	29.3147	8.3	Yes	Yes	1	9	9
36	A:A:K233	B:B:D246	29.1576	4.15	Yes	No	1	9	9
37	A:A:C237	B:B:Q75	42.7469	4.58	No	Yes	0	8	9
38	A:A:C237	B:B:M101	42.6807	4.86	No	Yes	0	8	9
39	B:B:Q75	B:B:Y59	42.7469	3.38	Yes	No	0	9	8
40	B:B:M101	B:B:Y59	42.6807	10.78	Yes	No	0	9	8
41	B:B:K57	B:B:W332	90.6329	17.4	Yes	Yes	5	9	9
42	B:B:K57	B:B:Q75	90.5598	13.56	Yes	Yes	0	9	9
43	A:A:F290	A:A:I288	43.2939	3.77	Yes	No	0	9	9
44	A:A:F290	A:A:T364	86.8748	6.49	Yes	No	23	9	9
45	A:A:D378	A:A:I288	42.9703	9.8	No	No	0	7	9
46	A:A:D378	A:A:Y360	85.6293	17.24	No	No	0	7	8
47	A:A:F290	A:A:H362	43.2936	6.79	Yes	No	0	9	9
48	A:A:D378	A:A:H362	42.9889	8.82	No	No	0	7	9
49	A:A:D381	A:A:Y360	84.6408	13.79	No	No	0	8	8
50	A:A:D381	R:R:K388	75.2331	6.91	No	Yes	11	8	9
51	A:A:Q384	R:R:K388	72.3836	9.49	No	Yes	0	6	9
52	A:A:Q384	R:R:I310	72.0385	4.12	No	No	0	6	8
53	R:R:I310	R:R:L306	71.7271	4.28	No	No	0	8	9
54	A:A:Y391	R:R:L306	70.7217	9.38	Yes	No	0	4	9
55	A:A:Y391	W:W:?1	61.6052	4.97	Yes	Yes	6	4	0
56	R:R:I299	W:W:?1	13.6293	9.07	No	Yes	0	9	0
57	R:R:F230	R:R:I299	13.2905	3.77	Yes	No	0	8	9
58	R:R:F230	R:R:N295	20.4826	6.04	Yes	No	0	8	8
59	R:R:N295	R:R:S229	19.8195	8.94	No	No	0	8	9
60	R:R:S229	R:R:T294	19.1367	4.8	No	No	0	9	8
61	R:R:T294	R:R:W329	15.0365	4.85	No	Yes	19	8	9
62	R:R:H225	R:R:W329	10.2546	8.46	No	Yes	19	8	9
63	R:R:F417	W:W:?1	31.6951	12.9	No	Yes	0	9	0
64	R:R:F230	R:R:F417	13.2901	4.29	Yes	No	0	8	9
65	B:B:D228	B:B:S227	29.755	4.42	Yes	No	0	9	6
66	B:B:D247	B:B:S227	58.4394	4.42	Yes	No	0	9	6
67	B:B:D247	B:B:H225	38.8552	5.04	Yes	Yes	3	9	9
68	B:B:H225	B:B:T243	19.9198	6.85	Yes	Yes	3	9	8
69	B:B:F253	B:B:T243	16.0086	7.78	Yes	Yes	3	6	8
70	B:B:F222	B:B:F253	45.0851	10.72	Yes	Yes	3	8	6
71	B:B:D258	B:B:F222	35.2941	5.97	Yes	Yes	3	7	8
72	B:B:D258	B:B:R22	31.3793	9.53	Yes	Yes	3	7	6
73	B:B:I18	B:B:R22	25.5017	7.52	No	Yes	0	7	6
74	B:B:I18	G:G:L19	19.6195	1.43	No	No	0	7	9
75	B:B:A11	G:G:L19	17.6584	1.58	No	No	0	5	9
76	B:B:A11	G:G:V16	15.6971	1.7	No	No	0	5	7
77	B:B:E10	G:G:V16	13.7356	2.85	No	No	0	8	7
78	B:B:E10	B:B:L7	11.7739	3.98	No	Yes	0	8	8
79	B:B:D246	B:B:S227	29.0068	5.89	No	No	0	9	6
80	B:B:H225	B:B:R251	17.6382	14.67	Yes	Yes	3	9	8
81	B:B:F253	B:B:R251	32.0123	4.28	Yes	Yes	3	6	8
82	B:B:D247	B:B:T249	18.6136	7.23	Yes	No	0	9	6
83	B:B:R251	B:B:T249	17.6369	9.06	Yes	No	0	8	6
84	B:B:G162	B:B:Y145	27.8322	10.14	No	Yes	1	9	8
85	B:B:G162	B:B:S161	28.4075	3.71	No	No	1	9	9
86	B:B:H142	B:B:S161	27.2205	15.34	Yes	No	1	9	9
87	B:B:H142	B:B:T159	11.5798	6.85	Yes	Yes	1	9	9
88	B:B:H142	B:B:W169	15.4965	4.23	Yes	Yes	1	9	8
89	B:B:L139	B:B:W169	14.4899	12.53	No	Yes	0	9	8
90	B:B:I123	B:B:L139	14.3214	4.28	Yes	No	0	6	9
91	B:B:I123	B:B:Y111	11.4377	3.63	Yes	Yes	1	6	4
92	B:B:C271	B:B:D290	12.0373	3.11	No	Yes	5	5	6
93	B:B:C271	B:B:Y289	11.3948	4.03	No	Yes	5	5	7
94	R:R:F417	R:R:Q451	18.0679	4.68	No	No	0	9	9
95	R:R:Q451	R:R:R233	17.0499	17.52	No	Yes	0	9	8
96	R:R:R233	R:R:Y296	12.324	5.14	Yes	Yes	14	8	7
97	B:B:M101	B:B:Y145	85.0712	8.38	Yes	Yes	0	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
A:A:L393	A:A:Y391	5.86	0	No	Yes	8	4	2	1
A:A:Y391	R:R:R219	7.2	6	Yes	Yes	4	9	1	1
A:A:Y391	R:R:L306	9.38	6	Yes	No	4	9	1	2
A:A:Y391	W:W:?1	4.97	6	Yes	Yes	4	0	1	0
A:A:E392	R:R:G464	4.91	0	No	No	6	7	1	2
A:A:E392	W:W:?1	5.62	0	No	Yes	6	0	1	0
R:R:N220	R:R:R219	9.64	6	No	Yes	9	9	2	1
R:R:H223	R:R:R219	7.9	6	Yes	Yes	9	9	1	1
R:R:E465	R:R:R219	3.49	6	Yes	Yes	9	9	2	1
R:R:R219	W:W:?1	3.22	6	Yes	Yes	9	0	1	0
R:R:H223	R:R:N220	5.1	6	Yes	No	9	9	1	2
R:R:E302	R:R:I222	6.83	6	Yes	No	9	9	1	2
R:R:E302	R:R:H223	9.85	6	Yes	Yes	9	9	1	1
R:R:H223	W:W:?1	8.17	6	Yes	Yes	9	0	1	0
R:R:F230	R:R:L226	9.74	0	Yes	No	8	9	2	2
R:R:E302	R:R:L226	10.6	6	Yes	No	9	9	1	2
R:R:F230	R:R:I299	3.77	0	Yes	No	8	9	2	1
R:R:F230	R:R:F417	4.29	0	Yes	No	8	9	2	1
R:R:F230	R:R:V455	10.49	0	Yes	No	8	9	2	2
R:R:I299	W:W:?1	9.07	0	No	Yes	9	0	1	0
R:R:E302	W:W:?1	12.63	6	Yes	Yes	9	0	1	0
R:R:L416	R:R:M414	7.07	0	No	No	9	8	1	2
R:R:L416	W:W:?1	7.33	0	No	Yes	9	0	1	0
R:R:F417	R:R:Q451	4.68	0	No	No	9	9	1	2
R:R:F417	W:W:?1	12.9	0	No	Yes	9	0	1	0
R:R:F450	R:R:F454	9.65	0	No	No	7	6	2	1
R:R:F454	R:R:I458	5.02	0	No	No	6	8	1	2
R:R:F454	W:W:?1	9.03	0	No	Yes	6	0	1	0
R:R:V455	R:R:Y459	3.79	0	No	No	9	8	2	1
R:R:Y459	W:W:?1	26.08	0	No	Yes	8	0	1	0
R:R:E465	R:R:N463	13.15	6	Yes	No	9	9	2	1
R:R:N463	R:R:V466	5.91	6	No	No	9	9	1	2
R:R:N463	W:W:?1	9.46	6	No	Yes	9	0	1	0
R:R:E465	R:R:V466	5.7	6	Yes	No	9	9	2	2
R:R:L416	R:R:V419	2.98	0	No	No	9	7	1	2
R:R:V412	W:W:?1	1.58	0	No	Yes	8	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
73.33	Single	8JR9	PCO371	8JR9-PTH1-PCO371-chim(NtGi1-Gs)/β1/γ2
31.82	Single	8FN0	PubChem 118610427	8FN0-NTS₁-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
25.00	Single	5T1A	PubChem 68764898; PubChem 12093170	5T1A-CCR2-PubChem 68764898; PubChem 12093170
25.00	Single	8JPB	PubChem 118610427; GDP; Mg	8JPB-NTS₁-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
22.22	Single	5XEZ	NNC0640	5XEZ-Glucagon-NNC0640
21.05	Single	8JPC	PubChem 118610427; GDP; Mg	8JPC-NTS₁-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
21.05	Single	8JPF	PubChem 118610427	8JPF-NTS₁-Neurotensin-PubChem 118610427
18.18	Single	5LWE	Vercirnon	5LWE-CCR9-Vercirnon
16.67	Single	8PJK	t7m	8PJK-5-HT_1A-ST171-t7m-Gi1/β1/γ1
15.00	Single	5XF1	NNC0640	5XF1-Glucagon-NNC0640
15.00	Single	6QZH	HY-133073; Na	6QZH-CCR7-HY-133073; Na
14.29	Single	6LFL	PubChem 153466996	6LFL-CXCR2-PubChem 153466996
14.29	Single	6UO8	GS39783	6UO8-GABA_B1, GABA_B2-SKF97541-GS39783
13.04	Single	8TB7	PubChem 168510218	8TB7-GPR61-PubChem 168510218
12.50	Single	8JD3	HZR; PEF	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
12.50	Single	8PKM	t7m	8PKM-5-HT_1A-Befiradol-t7m-Gi1/β1/γ1
11.54	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
11.11	Single	5VEX	NNC0640	5VEX-GLP-1-NNC0640
11.11	Single	6KK7	PubChem 68178630	6KK7-GLP-1-PubChem 68178630
11.11	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
10.53	Single	4K5Y	CP-376395	4K5Y-CRF₁-CP-376395
10.53	Single	5VEW	PF-06372222	5VEW-GLP-1-PF-06372222
10.53	Single	6KJV	PubChem 68178630	6KJV-GLP-1-PubChem 68178630
10.53	Single	6KK1	PubChem 68178630	6KK1-GLP-1-PubChem 68178630
10.00	Single	5X7D	PubChem 129318963	5X7D-β₂-S-Carazolol-PubChem 129318963
9.52	Single	4Z9G	CP-376395	4Z9G-CRF₁-CP-376395
9.52	Single	8GTI	BMK-C205	8GTI-CRF₁-BMK-C205
9.09	Single	8GTG	BMK-I152	8GTG-CRF₁-BMK-I152
8.70	Single	8J20	AR420626	8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
8.33	Single	8GTM	BMK-C203	8GTM-CRF₁-BMK-C203
8.33	Single	8JD5	BQI; HZE; PEF	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
8.00	Single	6LN2	PubChem 68178630	6LN2-GLP-1-PubChem 68178630
7.69	Single	6XBJ	Cholesterol	6XBJ-SMO-Cholesterol-Gi1/β1/γ2
7.69	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
6.67	Single	4PXF	Octyl-Beta-D-Glucopyranoside	4PXF-Rhodopsin-Octyl-β-D-Glucopyranoside-Arrestin1 Finger Loop
6.67	Single	8ZPM	Cholesterol	8ZPM-CXCR4-AMD070-Cholesterol
5.88	Single	7EB2	rac-BHFF	7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
5.56	Single	8XQP	Aristolochic acid A	8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
5.56	Single	8Y69	Cholesterol	8Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
5.26	Single	7CA3	rac-BHFF	7CA3-GABA_B1, GABA_B2-rac-BHFF
5.26	Single	7LD3	PubChem 25263603	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/β1/γ2
5.26	Single	8HNN	SCH546738	8HNN-CXCR3-SCH546738
5.26	Single	8Y69	Cholesterol	8Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
5.00	Single	7C7Q	PubChem 7023848	7C7Q-GABA_B1, GABA_B2-Baclofen-PubChem 7023848
5.00	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
5.00	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
5.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.00	Single	8A6C	All-trans-Retinal	8A6C-Rhodopsin-All-trans-Retinal
5.00	Single	8A6D	All-trans-Retinal	8A6D-Rhodopsin-All-trans-Retinal
5.00	Single	8A6E	All-trans-Retinal	8A6E-Rhodopsin-All-trans-Retinal
5.00	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
5.00	Single	8XQT	Cholesterol	8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
5.00	Single	9AVL	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.76	Single	3OAX	11-cis-Retinal	3OAX-Rhodopsin-11-cis-Retinal
4.76	Single	6A94	Zotepine	6A94-5-HT_2A-Zotepine
4.76	Single	7VOD	Cariprazine	7VOD-5-HT_2A-Cariprazine
4.76	Single	7ZBC	11-cis-Retinal	7ZBC-Rhodopsin-11-cis-Retinal
4.76	Single	7ZBE	11-cis-Retinal	7ZBE-Rhodopsin-11-cis-Retinal
4.76	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.76	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.76	Single	9ASB	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76	Single	9AVG	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.76	Consensus	5ht2a_off	Orthosteric Ligand	6A94-5-HT_2A-Zotepine 6A93-5-HT_2A-Risperidone 7VOD-5-HT_2A-Cariprazine 7WC8-5-HT_2A-Lumateperone 8JT8-5-HT_2A-(R)-IHCH-7179
4.55	Single	1HZX	11-cis-Retinal	1HZX-Rhodopsin-11-cis-Retinal
4.55	Single	6FKD	PubChem 137349183	6FKD-Rhodopsin-PubChem 137349183
4.55	Single	7F83	PF-05190457	7F83-Ghrelin-PF-05190457
4.55	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
4.55	Single	7RBT	PubChem 163183774	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
4.55	Single	7WC8	Lumateperone	7WC8-5-HT_2A-Lumateperone
4.55	Single	8JT8	(R)-IHCH-7179	8JT8-5-HT_2A-(R)-IHCH-7179
4.55	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
4.55	Single	8XQL	Aristolochic acid A	8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
4.35	Single	6LUQ	Haloperidol	6LUQ-D₂-Haloperidol
4.35	Single	7M3J	NPS-2143; PO4	7M3J-CaS-NPS-2143; PO4
4.35	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
4.35	Single	7SIN	NPS-2143	7SIN-CaS-NPS-2143
4.35	Single	7VOE	Aripiprazole	7VOE-5-HT_2A-Aripiprazole
4.35	Single	8YNS	SNAP-94847	8YNS-MCH1-SNAP-94847
4.35	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.17	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
4.17	Single	8JD5	BQI; HZE; PEF	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
4.17	Single	8TAO	CDPPB	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.17	Single	8X0F	VU0424465	8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
4.17	Single	8YNT	SNAP-94847	8YNT-MCH1-SNAP-94847
4.00	Single	6A93	Risperidone	6A93-5-HT_2A-Risperidone
4.00	Single	6CM4	Risperidone	6CM4-D₂-Risperidone
4.00	Single	6XBL	Cholesterol	6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
3.85	Consensus	d2_off	Orthosteric Ligand	6CM4-D₂-Risperidone 6LUQ-D₂-Haloperidol 7DFP-D₂-Spiperone
3.70	Single	8IEI	A1LYA	8IEI-GPR156-A1LYA
3.57	Single	8IEB	A1LYA	8IEB-GPR156-A1LYA
3.57	Single	8IEI	A1LYA	8IEI-GPR156-A1LYA
3.57	Single	8IEP	A1LYA	8IEP-GPR156-A1LYA
3.57	Single	8IEP	A1LYA	8IEP-GPR156-A1LYA
3.45	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
3.45	Single	8IEB	A1LYA	8IEB-GPR156-A1LYA
3.23	Single	8IED	A1LYA	8IED-GPR156-A1LYA-Go/β1/γ2
3.23	Single	8IED	A1LYA	8IED-GPR156-A1LYA-Go/β1/γ2
3.03	Single	3VG9	Antibody	3VG9-A_2A-ZM-241385-Antibody
2.78	Single	3VGA	Antibody	3VGA-A_2A-ZM-241385-Antibody

PDB Summary
PDB	8GW8
Class	B1
SubFamily	Peptide
Type	Parathyroid Hormone
SubType	PTH1
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	KHF
Protein Partners	Gs/Beta1/Gamma2
PDB Resolution	2.9
Date	2023-06-14
D.O.I.	10.1038/s41586-023-06169-3

Net Summary
I_min	3
Number of Linked Nodes	798
Number of Links	978
Number of Hubs	158
Number of Links mediated by Hubs	578
Number of Communities	27
Number of Nodes involved in Communities	229
Number of Links involved in Communities	325

Path Summary
Number Of Nodes in MetaPath	98
Number Of Links MetaPath	97
Number of Shortest Paths	4945211
Length Of Smallest Path	3
Average Path Length	44.1739
Length of Longest Path	72
Minimum Path Strength	1.17
Average Path Strength	7.98779
Maximum Path Strength	23.49
Minimum Path Correlation	0.7
Average Path Correlation	0.991401
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.12766
Average % Of Corr. Nodes	27.0025
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	51.1326
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • protein binding • binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to stimulus • response to stimulus • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to stress • response to chemical • response to oxygen levels • response to abiotic stimulus • cellular process • cell population proliferation • regulation of biological process • regulation of cellular process • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • cell projection membrane • synapse • cell junction • cell body • G-protein beta-subunit binding • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • identical protein binding • protein homodimerization activity • protein dimerization activity • amide binding • peptide hormone binding • hormone binding • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • parathyroid hormone receptor activity • ossification • bone mineralization • biomineral tissue development • tissue development • skeletal system development • inorganic ion homeostasis • intracellular calcium ion homeostasis • homeostatic process • calcium ion homeostasis • cellular homeostasis • chemical homeostasis • intracellular monoatomic cation homeostasis • monoatomic ion homeostasis • intracellular chemical homeostasis • monoatomic cation homeostasis • intracellular monoatomic ion homeostasis • osteoblast development • cellular developmental process • cell differentiation • cell development • osteoblast differentiation • embryo development ending in birth or egg hatching • chordate embryonic development • embryo development • in utero embryonic development • anatomical structure maturation • cell maturation • developmental maturation • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • cell surface receptor signaling pathway • negative regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • connective tissue development • chondrocyte differentiation • cartilage development • regulation of inositol phosphate biosynthetic process • alcohol metabolic process • positive regulation of phosphate metabolic process • inositol phosphate metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • regulation of phosphate metabolic process • phosphate-containing compound metabolic process • polyol biosynthetic process • small molecule metabolic process • phosphorus metabolic process • regulation of carbohydrate metabolic process • regulation of biosynthetic process • carbohydrate metabolic process • polyol metabolic process • positive regulation of phosphorus metabolic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • carbohydrate biosynthetic process • primary metabolic process • positive regulation of inositol phosphate biosynthetic process • biosynthetic process • organophosphate metabolic process • organophosphate biosynthetic process • inositol phosphate biosynthetic process • alcohol biosynthetic process • regulation of phosphorus metabolic process • metabolic process • positive regulation of carbohydrate metabolic process • regulation of carbohydrate biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • multicellular organismal-level homeostasis • tissue remodeling • bone remodeling • anatomical structure homeostasis • tissue homeostasis • bone resorption • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • apical part of cell • apical plasma membrane • basal part of cell • basal plasma membrane • basolateral plasma membrane • receptor complex
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	KHF
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	KHF
Name	PCO-371
Synonyms	1-[3,5-dimethyl-4-[2-[[4-oxidanylidene-2-[4-(trifluoromethyloxy)phenyl]-1,3,8-triazaspiro[4.5]dec-1-en-8-yl]sulfonyl]ethyl]phenyl]-5,5-dimethyl-imidazolidine-2,4-dione
Identifier
Formula	C29 H32 F3 N5 O6 S
Molecular Weight	635.654
SMILES
PubChem	76283707
Formal Charge	0
Total Atoms	76
Total Chiral Atoms	0
Total Bonds	80
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	A
Protein	G Protein α Sub unit
UniProt	P63092
Sequence	>8GW8_Chain_A Q R N E E K A Q R E A N K K I E K Q L Q K D K Q V Y R A T H R L L L L G A D N S G K S T I V K Q M R I G I F E T K F Q V D K V N F H M F D V G G Q R D E R R K W I Q C F N D V T A I I F V V D S S D Y N R L Q E A L N L F K S I W N N R W L R T I S V I L F L N K Q D L L A E K V L A G K S K I E D Y F P E F A R Y T T P E D A T P E P G E D P R V T R A K Y F I R D E F L R I S T A S G D G R H Y C Y P H F T C A V D T E N A R R I F N D C R D I I Q R M H L R Q Y E L L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	B
Protein	G Protein β Sub unit
UniProt	P54311
Sequence	>8GW8_Chain_B Q S E L D Q L R Q E A E Q L K N Q I R D A R K A C A D A T L S Q I T N N I D P V G R I Q M R T R R T L R G H L A K I Y A M H W G T D S R L L V S A S Q D G K L I I W D S Y T T N K V H A I P L R S S W V M T C A Y A P S G N Y V A C G G L D N I C S I Y N L K T R E G N V R V S R E L A G H T G Y L S C C R F L D D N Q I V T S S G D T T C A L W D I E T G Q Q T T T F T G H T G D V M S L S L A P D T R L F V S G A C D A S A K L W D V R E G M C R Q T F T G H E S D I N A I C F F P N G N A F A T G S D D A T C R L F D L R A D Q E L M T Y S H D N I I C G I T S V S F S K S G R L L L A G Y D D F N C N V W D A L K A D R A G V L A G H D N R V S C L G V T D D G M A V A T G S W D S F L K I W N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	G
Protein	G Protein γ Sub unit
UniProt	P63212
Sequence	>8GW8_Chain_G T A S I A Q A R K L V E Q L K M E A N I D R I K V S K A A A D L M A Y C E A H A K E D P L L T P V P A S E N P F R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	Q03431
Sequence	>8GW8_Chain_R Y T V G Y S V S L A S L T V A V L I L A Y F R R L H C T R N Y I H M H L F L S F M L R A V S I F V K D A V L Y S C R V A V T F F L Y F L A T N Y Y W I L V E G L Y L H S L I F M A F F S K Y L W G F T V F G W G L P A V F V A V W V S V R A T L K W I I Q V P I L A S I V L N F I L F I N I V R V L A T K L R E T N A G R C D T R Q Q Y R K L L K S T L V L M P L F G V H Y I V F M M L F N S F Q G F F V A I I Y C F C N G E V Q A E I K K S W S R W T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9JR3	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-10-16	To be published
	9JR3 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2024-10-16	To be published
	9JR2	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-10-16	To be published
	9JR2 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2024-10-16	To be published
	8JR9	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371	chim(NtGi1-Gs)/β1/γ2	2.57	2023-08-02	10.1038/s41586-023-06467-w
	8JR9 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	PCO371		2.57	2023-08-02	10.1038/s41586-023-06467-w
	7Y36	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Teriparatide	-	Gs/β1/γ2	2.8	2023-07-05	To be published
	7Y36 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Teriparatide	-		2.8	2023-07-05	To be published
	7Y35	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/β1/γ2	2.9	2023-07-05	To be published
	7Y35 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-		2.9	2023-07-05	To be published
	8GW8	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	KHF	Gs/β1/γ2	2.9	2023-06-14	10.1038/s41586-023-06169-3
	8GW8 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	-	KHF		2.9	2023-06-14	10.1038/s41586-023-06169-3
	8FLU	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-	Gs/β1/γ2	2.76	2023-04-26	10.1016/j.str.2023.04.002
	8FLU (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH	-		2.76	2023-04-26	10.1016/j.str.2023.04.002
	8FLT	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	M-PTH(1-14)	-	Gs/β1/γ2	3.03	2023-04-26	10.1016/j.str.2023.04.002
	8FLT (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	M-PTH(1-14)	-		3.03	2023-04-26	10.1016/j.str.2023.04.002
	8FLS	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-	Gs/β1/γ2	3.09	2023-04-26	10.1016/j.str.2023.04.002
	8FLS (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Abaloparatide	-		3.09	2023-04-26	10.1016/j.str.2023.04.002
	8FLR	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/β1/γ2	2.94	2023-04-26	10.1016/j.str.2023.04.002
	8FLR (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		2.94	2023-04-26	10.1016/j.str.2023.04.002
	8FLQ	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.55	2023-04-26	10.1016/j.str.2023.04.002
	8FLQ (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.55	2023-04-26	10.1016/j.str.2023.04.002
	8HAO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/β1/γ2	3.76	2022-12-21	10.1038/s41401-022-01032-z
	8HAO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.76	2022-12-21	10.1038/s41401-022-01032-z
	8HAF	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	chim(NtGi1-Gs)/β1/γ2	3.25	2022-12-21	10.1038/s41401-022-01032-z
	8HAF (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		3.25	2022-12-21	10.1038/s41401-022-01032-z
	8HA0	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	chim(NtGi1-Gs)/β1/γ2	2.62	2022-12-21	10.1038/s41401-022-01032-z
	8HA0 (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.62	2022-12-21	10.1038/s41401-022-01032-z
	7VVO	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	4.1	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVO (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		4.1	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVN	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.8	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVN (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.8	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVM	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.2	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVM (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.2	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVL	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	2.8	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVL (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		2.8	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVK	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	Gs/β1/γ2	3.3	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVK (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-		3.3	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVJ	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-	Gs/β1/γ2	3.2	2022-08-03	10.1016/j.molcel.2022.07.003
	7VVJ (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTHrP(1-36)	-		3.2	2022-08-03	10.1016/j.molcel.2022.07.003
	6NBI	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	4	2019-04-17	10.1126/science.aav7942
	6NBI (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		4	2019-04-17	10.1126/science.aav7942
	6NBH	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	3.5	2019-04-17	10.1126/science.aav7942
	6NBH (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		3.5	2019-04-17	10.1126/science.aav7942
	6NBF	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-	Gs/β1/γ2	3	2019-04-17	10.1126/science.aav7942
	6NBF (No Gprot)	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	Long-Acting PTH Analog	-		3	2019-04-17	10.1126/science.aav7942
	6FJ3	B1	Peptide	Parathyroid Hormone	PTH1	Homo sapiens	PTH	-	-	2.5	2018-11-21	10.1038/s41594-018-0151-4

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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