Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:Y138 6.242535
2R:R:F141 9.116536
3R:R:Q142 8.31435
4R:R:Y145 7.615637
5R:R:Y149 7.71333608
6R:R:L156 4.405408
7R:R:L163 3.7575408
8R:R:L169 4.885469
9R:R:N174 5.5975409
10R:R:F181 5.3025408
11R:R:F184 9.3725408
12R:R:D195 8.86437
13R:R:L216 3.465402
14R:R:C224 4.1975409
15R:R:M231 2.7325406
16R:R:Y239 7.6625418
17R:R:W241 14.0925479
18R:R:E245 11.365449
19R:R:Y248 4.9475408
20R:R:W272 11.225479
21R:R:P275 4.625409
22R:R:W282 11.645419
23R:R:K286 11.4025418
24R:R:Q293 4.6675404
25R:R:W295 11.3433619
26R:R:F303 6.956514
27R:R:W304 12.2417616
28R:R:W305 10.93417
29R:R:L307 5.285417
30R:R:R308 8.44571716
31R:R:F312 5.2425415
32R:R:M338 4.42525
33R:R:Y343 5.165427
34R:R:F345 4.738527
35R:R:R346 9.17428
36R:R:F362 8.56618
37R:R:T369 6.695417
38R:R:Y400 12.936548
39R:R:C401 4.3825409
40R:R:F402 4.595409
41R:R:V407 4.935409
42R:R:E410 7.1775468
43W:W:?1 8.38857720
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:F141 R:R:Y145 10.344510.32YesYes367
2R:R:Y145 R:R:Y149 24.82683.97YesYes078
3R:R:K187 R:R:Y149 44.660510.75NoYes088
4R:R:V191 R:R:Y149 11.739715.14NoYes078
5R:R:I235 R:R:K187 45.68788.72NoNo058
6R:R:F303 R:R:I235 46.648211.3YesNo045
7R:R:F303 R:R:F362 85.38877.5YesYes148
8R:R:F362 R:R:Y239 91.710113.41YesYes188
9R:R:L358 R:R:Y239 1003.52NoYes098
10R:R:L242 R:R:L358 99.3554.15NoNo099
11R:R:I355 R:R:L242 99.23555.71NoNo089
12R:R:I355 R:R:P356 98.66213.39NoNo089
13R:R:F322 R:R:P356 98.49014.33NoNo099
14R:R:F322 R:R:L352 98.07926.09NoNo098
15R:R:I325 R:R:L352 92.23577.14NoNo098
16R:R:I325 R:R:L249 90.7647.14NoNo099
17R:R:L249 R:R:L347 89.43095.54NoNo099
18R:R:L347 R:R:Y343 89.23037.03NoYes097
19R:R:E406 R:R:Y343 38.64494.49NoYes297
20R:R:E406 R:R:N404 38.582810.52NoNo099
21R:R:N404 R:R:V407 42.26678.87NoYes099
22R:R:C401 R:R:V407 27.97553.42YesYes099
23R:R:A159 R:R:C401 20.32593.61NoYes099
24R:R:A159 R:R:F181 19.47544.16NoYes098
25R:R:F181 R:R:L156 19.99144.87YesYes088
26R:R:G393 R:R:L156 12.25095.13NoYes098
27R:R:L169 R:R:V407 15.47144.47YesYes099
28R:R:L169 R:R:N174 10.21074.12YesYes099
29R:R:L163 R:R:N174 11.46736.87YesYes089
30R:R:A173 R:R:Y343 25.22824NoYes097
31R:R:A173 R:R:Y248 24.53065.34NoYes098
32R:R:I176 R:R:Y248 22.394.84NoYes098
33R:R:E245 R:R:I176 11.62986.83YesNo099
34R:R:R346 R:R:Y343 26.98655.14YesYes287
35R:R:R346 W:W:?1 25.95449.93YesYes280
36R:R:S350 W:W:?1 12.74796.13NoYes090
37R:R:I176 R:R:V244 24.01934.61NoNo098
38R:R:V244 R:R:W241 14.50627.36NoYes089
39R:R:F303 R:R:Q232 33.43694.68YesNo147
40R:R:Q232 R:R:W304 32.629430.67NoYes176
41R:R:W295 R:R:W304 49.39087.5YesYes196
42R:R:R225 R:R:W295 43.174528.99NoYes189
43R:R:R225 R:R:V221 41.44013.92NoNo084
44R:R:L216 R:R:V221 39.29954.47YesNo024
45R:R:C224 R:R:L216 22.06513.17YesYes092
46R:R:C224 R:R:C294 15.96837.28YesNo099
47R:R:C294 R:R:T296 13.72745.07NoNo095
48R:R:Q293 R:R:T296 11.46262.83YesNo045
49R:R:F303 R:R:L307 34.42594.87YesYes147
50R:R:L307 R:R:W304 32.80147.97YesYes176
51R:R:A220 R:R:L216 11.46264.73NoYes062
52R:R:V236 R:R:V311 12.33693.21NoNo068
53R:R:P275 R:R:V236 11.00397.07YesNo096
54R:R:L253 R:R:L328 10.79365.54NoNo088
55R:R:W282 R:R:W304 11.080313.12YesYes196
56R:R:V285 R:R:W282 12.246214.71NoYes059
57R:R:F362 R:R:R308 15.64814.28YesYes186
58R:R:F345 W:W:?1 17.03864.35YesYes270
59R:R:F345 R:R:M338 10.83664.98YesYes275
60R:R:L358 R:R:Q392 10.92745.32NoNo099
61R:R:M231 R:R:V191 10.42573.04YesNo067
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L333 R:R:M338 5.65 2 No Yes 7 5 2 2
R:R:F345 R:R:L333 4.87 2 Yes No 7 7 1 2
R:R:F345 R:R:M338 4.98 2 Yes Yes 7 5 1 2
R:R:F345 R:R:H340 4.53 2 Yes No 7 5 1 2
R:R:R346 R:R:Y343 5.14 2 Yes Yes 8 7 1 2
R:R:E406 R:R:Y343 4.49 2 No Yes 9 7 2 2
R:R:F345 R:R:K349 4.96 2 Yes No 7 9 1 1
R:R:F345 W:W:?1 4.35 2 Yes Yes 7 0 1 0
R:R:K405 R:R:R346 11.14 0 No Yes 6 8 2 1
R:R:E406 R:R:R346 10.47 2 No Yes 9 8 2 1
R:R:R346 W:W:?1 9.93 2 Yes Yes 8 0 1 0
R:R:K349 W:W:?1 18.72 2 No Yes 9 0 1 0
R:R:L399 R:R:S350 7.51 0 No No 8 9 2 1
R:R:S350 R:R:Y400 6.36 0 No Yes 9 8 1 2
R:R:S350 W:W:?1 6.13 0 No Yes 9 0 1 0
R:R:T353 W:W:?1 9.03 0 No Yes 8 0 1 0
R:R:L403 W:W:?1 5.65 0 No Yes 5 0 1 0
R:R:E406 R:R:N404 10.52 2 No No 9 9 2 1
R:R:N404 R:R:V407 8.87 0 No Yes 9 9 1 2
R:R:N404 W:W:?1 4.91 0 No Yes 9 0 1 0
R:R:L403 R:R:Q408 1.33 0 No No 5 7 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
87.50Single5VEXNNC06405VEX-GLP-1-NNC0640
87.50Single6KK7PF-063722226KK7-GLP-1-PF-06372222
77.78Single6KJVPF-063722226KJV-GLP-1-PF-06372222
77.78Single6KK1PF-063722226KK1-GLP-1-PF-06372222
70.00Single5XEZNNC06405XEZ-Glucagon-NNC0640
63.64Single5XF1NNC06405XF1-Glucagon-NNC0640
60.00Single5VEWPF-063722225VEW-GLP-1-PF-06372222
46.67Single6LN2PF-063722226LN2-GLP-1-PF-06372222
31.25Single8TB7PubChem 1685102188TB7-GPR61-PubChem 168510218
30.00Single7EB2rac-BHFF7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
25.00Single7CA3rac-BHFF7CA3-GABAB1, GABAB2-rac-BHFF
23.08Single7C7QBHFF7C7Q-GABAB1, GABAB2-Baclofen-BHFF
22.22Single4PXFOctyl-Beta-D-Glucopyranoside4PXF-Rhodopsin-Octyl-β-D-Glucopyranoside-Arrestin1 Finger Loop
22.22Single7DUQPubChem 1560227387DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
21.43Single5X7DCmpd-155X7D-β2-S-Carazolol-Cmpd-15
20.00Single8JPFSBI-5538JPF-NTS1-Neurotensin-SBI-553
15.38Single5T1APubChem 120931705T1A-CCR2-BMS-681-PubChem 12093170
14.29Single7DURPubChem 1560227387DUR-GLP-1-PubChem 156022738-Gs/β1/γ2
13.33Single8XQSFlufenamic acid8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
12.50Single7E14PubChem 1560227387E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
12.50Single7EVMPubChem 1560227387EVM-GLP-1-PubChem 156022738-Gs/β1/γ2
12.50Single8JPCSBI-553; GDP; Mg8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
11.76Single8GW8PCO3718GW8-PTH1-PCO371-Gs/β1/γ2
11.11Single8JPBSBI-553; GDP; Mg8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
10.53Single5LWEVercirnon5LWE-CCR9-Vercirnon
10.53Single8JR9PCO3718JR9-PTH1-PCO371-chim(NtGi1-Gs)/β1/γ2
10.53Single8ZYUSBI-5538ZYU-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
10.53Single8ZYYSBI-5538ZYY-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
10.00Single6UO8GS397836UO8-GABAB1, GABAB2-SKF97541-GS39783
9.09Single8ZYTSBI-5538ZYT-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
6.67Single8XQRFlufenamic acid8XQR-TAS2R14-Flufenamic acid-Gt3/β1/γ1
6.25Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
6.25Single8XQOAristolochic acid A8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
5.88Single8XQLAristolochic acid A8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
5.56Single6LFLPubChem 1534669966LFL-CXCR2-PubChem 153466996
4.35Single8FN0SBI-5538FN0-NTS1-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2

PDB Summary
PDB 5EE7
Class B1
SubFamily Peptide
Type Glucagon
SubType Glucagon
Species Homo Sapiens
Ligand -
Other Ligand(s) MK0893
Protein Partners -
PDB Resolution 2.5
Date 2016-04-20
D.O.I. doi.org/10.1038/nature17414
Net Summary
Imin 3.39
Number of Linked Nodes 248
Number of Links 283
Number of Hubs 43
Number of Links mediated by Hubs 157
Number of Communities 8
Number of Nodes involved in Communities 51
Number of Links involved in Communities 70
Path Summary
Number Of Nodes in MetaPath 62
Number Of Links MetaPath 61
Number of Shortest Paths 39225
Length Of Smallest Path 3
Average Path Length 16.401
Length of Longest Path 36
Minimum Path Strength 1.425
Average Path Strength 7.02582
Maximum Path Strength 24.36
Minimum Path Correlation 0.7
Average Path Correlation 0.922403
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.44828
Average % Of Corr. Nodes 40.2169
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 39.0479
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• hydrolase activity, acting on glycosyl bonds   • peptidoglycan muralytic activity   • hydrolase activity, hydrolyzing O-glycosyl compounds   • lysozyme activity   • hydrolase activity   • catalytic activity   • glucagon receptor activity   • peptide receptor activity   • molecular transducer activity   • G protein-coupled receptor activity   • G protein-coupled peptide receptor activity   • signaling receptor activity   • transmembrane signaling receptor activity   • amide binding   • binding   • peptide hormone binding   • hormone binding   • GTPase regulator activity   • enzyme regulator activity   • guanyl-nucleotide exchange factor activity   • nucleoside-triphosphatase regulator activity   • molecular function regulator activity   • defense response to bacterium   • biological process involved in interspecies interaction between organisms   • response to stimulus   • response to other organism   • defense response   • response to bacterium   • response to stress   • response to external stimulus   • response to external biotic stimulus   • response to biotic stimulus   • carbohydrate derivative catabolic process   • catabolic process   • peptidoglycan catabolic process   • glycosaminoglycan metabolic process
Gene OntologyBiological Process• defense response to bacterium   • biological process involved in interspecies interaction between organisms   • response to stimulus   • response to other organism   • defense response   • response to bacterium   • response to stress   • response to external stimulus   • response to external biotic stimulus   • response to biotic stimulus   • carbohydrate derivative catabolic process   • catabolic process   • peptidoglycan catabolic process   • glycosaminoglycan metabolic process   • carbohydrate derivative metabolic process   • aminoglycan catabolic process   • macromolecule catabolic process   • glycosaminoglycan catabolic process   • aminoglycan metabolic process   • peptidoglycan metabolic process   • metabolic process   • cellular process   • macromolecule metabolic process   • symbiont-mediated cytolysis of host cell   • viral life cycle   • disruption of cell in another organism   • cytolysis   • biological process involved in interaction with host   • biological process involved in symbiotic interaction   • viral release from host cell by cytolysis   • exit from host cell   • viral process   • cytolysis in another organism   • viral release from host cell   • disruption of anatomical structure in another organism   • symbiont-mediated killing of host cell   • killing of cells of another organism   • cell killing   • cell wall organization or biogenesis   • cell wall macromolecule catabolic process   • cell wall macromolecule metabolic process   • multicellular organismal process   • system process   • circulatory system process   • regulation of blood pressure   • biological regulation   • regulation of biological quality   • blood circulation   • regulation of biosynthetic process   • regulation of biological process   • regulation of cellular process   • positive regulation of biological process   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • positive regulation of macromolecule biosynthetic process   • regulation of gene expression   • positive regulation of metabolic process   • biosynthetic process   • positive regulation of gene expression   • positive regulation of biosynthetic process   • regulation of macromolecule biosynthetic process   • positive regulation of macromolecule metabolic process   • regulation of metabolic process   • positive regulation of cellular process   • cellular response to stimulus   • cellular response to nitrogen compound   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to chemical   • cellular response to hormone stimulus   • carbohydrate metabolic process   • energy derivation by oxidation of organic compounds   • glycogen metabolic process   • primary metabolic process   • regulation of generation of precursor metabolites and energy   • generation of precursor metabolites and energy   • regulation of polysaccharide metabolic process   • regulation of primary metabolic process   • glucan metabolic process   • polysaccharide metabolic process   • energy reserve metabolic process   • regulation of glycogen metabolic process   • regulation of carbohydrate metabolic process   • signaling   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to nutrient levels   • response to nutrient levels   • cellular response to stress   • response to starvation   • cellular response to starvation   • cell surface receptor signaling pathway   • response to nutrient   • chemical homeostasis   • homeostatic process   • glucose homeostasis   • carbohydrate homeostasis   • host cellular component   • host intracellular part   • cellular anatomical structure   • host cell cytoplasm   • host cell part   • host intracellular region   • other organism part   • membrane   • cell periphery   • plasma membrane
Gene OntologyCellular Component
SCOP2Domain Identifier• G protein-coupled receptor-like
SCOP2Family Identifier• G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
Code5MV
PDB ResiduesW:W:?1
Environment DetailsOpen EMBL-EBI Page
Code5MV
NameMK-0893
SynonymsMK-0893
Identifier
FormulaC32 H27 Cl2 N3 O4
Molecular Weight588.48
SMILES
PubChem11570626
Formal Charge0
Total Atoms68
Total Chiral Atoms1
Total Bonds72
Total Aromatic Bonds28

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP47871
Sequence
>5EE7_Chain_R
YSSFQVMYT VGYSLSLAA LLLALAILG GLSKLHCTA NAIHANLFL 
SFVLKASAV LFIDGLLRT VSTWLSDGA VAACRVAAV FMQYGIVAN 
YCWLLVEGL YLHNLLGLP ERSFFSLYL GIGWGAPAL FVVPWAVVK 
CLFENVQCW TNMGFWWIL RFPVFLAIL INFFIFVRI VQLLVAKLR 
ARQMHHTDY AFRLAKSTL TLIPLLGVH FVVFAFVTD EHRSAKLFF 
DLALSSFQG LLVAVLYCF LNKEVQSEL RRRWHRA


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6ORVB1PeptideGlucagonGLP-1Homo sapiens-TT-OAD2Gs/β1/γ232020-01-08doi.org/10.1038/s41586-019-1902-z
6ORV (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens-TT-OAD232020-01-08doi.org/10.1038/s41586-019-1902-z
7E14B1PeptideGlucagonGLP-1Homo sapiensOrforglipronPubChem 156022738Gs/β1/γ22.92021-07-07doi.org/10.1038/s41467-021-24058-z
7E14 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensOrforglipronPubChem 1560227382.92021-07-07doi.org/10.1038/s41467-021-24058-z
7DUQB1PeptideGlucagonGLP-1Homo sapiensGLP-1PubChem 156022738Gs/β1/γ22.52021-07-14doi.org/10.1038/s41467-021-24058-z
7DUQ (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1PubChem 1560227382.52021-07-14doi.org/10.1038/s41467-021-24058-z
7DURB1PeptideGlucagonGLP-1Homo sapiens-PubChem 156022738Gs/β1/γ23.32021-08-11doi.org/10.1038/s41467-021-24058-z
7DUR (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens-PubChem 1560227383.32021-08-11doi.org/10.1038/s41467-021-24058-z
7EVMB1PeptideGlucagonGLP-1Homo sapiens-PubChem 156022738Gs/β1/γ22.52021-08-11doi.org/10.1038/s41467-021-24058-z
7EVM (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens-PubChem 1560227382.52021-08-11doi.org/10.1038/s41467-021-24058-z
5VEWB1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-2.72017-05-24doi.org/10.1038/nature22378
6LN2B1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-3.22020-03-18doi.org/10.1038/s41467-020-14934-5
6KJVB1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-2.82019-11-13doi.org/10.1107/S2052252519013496
6KK1B1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-2.82019-11-13doi.org/10.1107/S2052252519013496
6KK7B1PeptideGlucagonGLP-1Homo sapiens-PF-06372222-3.12019-11-13doi.org/10.1107/S2052252519013496
8WG8B1PeptideGlucagonGlucagonHomo sapiens-Peptidechim(NtGi1-Gs)/β1/γ22.712024-03-06doi.org/10.1038/s41421-024-00649-0
8WG8 (No Gprot) B1PeptideGlucagonGlucagonHomo sapiens-Peptide2.712024-03-06doi.org/10.1038/s41421-024-00649-0
5VEXB1PeptideGlucagonGLP-1Homo sapiens-NNC0640-32017-05-17doi.org/10.1038/nature22378
5XEZB1PeptideGlucagonGlucagonHomo sapiens-NNC0640-32017-05-24doi.org/10.1038/nature22363
5XF1B1PeptideGlucagonGlucagonHomo sapiens-NNC0640-3.192017-05-24doi.org/10.1038/nature22363
5EE7B1PeptideGlucagonGlucagonHomo sapiens-MK0893-2.52016-04-20doi.org/10.1038/nature17414
7RBTB1PeptideGlucagonGIPHomo sapiensTirzepatideLSN3556672chim(NtGi1-Gs)/β1/γ23.082022-04-13doi.org/10.1073/pnas.2116506119
7RBT (No Gprot) B1PeptideGlucagonGIPHomo sapiensTirzepatideLSN35566723.082022-04-13doi.org/10.1073/pnas.2116506119
9IVMB1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)LSN3318839chim(NtGi1-Gs)/β2/γ23.222024-11-13doi.org/10.1016/j.apsb.2024.09.002
9IVM (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)LSN33188393.222024-11-13doi.org/10.1016/j.apsb.2024.09.002
6VCBB1PeptideGlucagonGLP-1Homo sapiensGLP-1LSN3160440Gs/β1/γ23.32020-07-22doi.org/10.1038/s41589-020-0589-7
6VCB (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1LSN31604403.32020-07-22doi.org/10.1038/s41589-020-0589-7
7CZ5B1PeptideGlucagonGHRHHomo sapiensSomatoliberin-Gs/β1/γ22.62020-11-18doi.org/10.1038/s41467-020-18945-0
7CZ5 (No Gprot) B1PeptideGlucagonGHRHHomo sapiensSomatoliberin-2.62020-11-18doi.org/10.1038/s41467-020-18945-0
7V9MB1PeptideGlucagonGHRH (SV1)Homo sapiensSomatoliberin-Gs/β1/γ23.292021-10-20doi.org/10.1073/pnas.2106606118
7V9M (No Gprot) B1PeptideGlucagonGHRH (SV1)Homo sapiensSomatoliberin-3.292021-10-20doi.org/10.1073/pnas.2106606118
7V9LB1PeptideGlucagonGHRH (SV1)Homo sapiens--chim(NtGi1-Gs)/β1/γ22.62022-04-06doi.org/10.1073/pnas.2106606118
7V9L (No Gprot) B1PeptideGlucagonGHRH (SV1)Homo sapiens--2.62022-04-06doi.org/10.1073/pnas.2106606118
8WA3B1PeptideGlucagonGIPHomo sapiens--Gs/β1/γ22.862024-03-06doi.org/10.1038/s41421-024-00649-0
8WA3 (No Gprot) B1PeptideGlucagonGIPHomo sapiens--2.862024-03-06doi.org/10.1038/s41421-024-00649-0
7FINB1PeptideGlucagonGIPHomo sapiensPeptide-20; GGL-Gs/β1/γ23.12022-02-23doi.org/10.1038/s41467-022-28683-0
7FIN (No Gprot) B1PeptideGlucagonGIPHomo sapiensPeptide-20; GGL-3.12022-02-23doi.org/10.1038/s41467-022-28683-0
7FIYB1PeptideGlucagonGIPHomo sapiensTirzepatide-Gs/β1/γ23.42022-03-02doi.org/10.1038/s41467-022-28683-0
7FIY (No Gprot) B1PeptideGlucagonGIPHomo sapiensTirzepatide-3.42022-03-02doi.org/10.1038/s41467-022-28683-0
7VABB1PeptideGlucagonGIPHomo sapiensNon-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ23.22022-03-02doi.org/10.1038/s41467-022-28683-0
7VAB (No Gprot) B1PeptideGlucagonGIPHomo sapiensNon-Acylated Tirzepatide-3.22022-03-02doi.org/10.1038/s41467-022-28683-0
7RA3B1PeptideGlucagonGIPHomo sapiensGIP-chim(NtGi1-Gs)/β1/γ23.242022-04-13doi.org/10.1073/pnas.2116506119
7RA3 (No Gprot) B1PeptideGlucagonGIPHomo sapiensGIP-3.242022-04-13doi.org/10.1073/pnas.2116506119
8ITLB1PeptideGlucagonGIPHomo sapiens--Gs/β1/γ23.232023-10-18doi.org/10.1073/pnas.2306145120
8ITL (No Gprot) B1PeptideGlucagonGIPHomo sapiens--3.232023-10-18doi.org/10.1073/pnas.2306145120
8ITMB1PeptideGlucagonGIPHomo sapiens--Gs/β1/γ23.132023-10-18doi.org/10.1073/pnas.2306145120
8ITM (No Gprot) B1PeptideGlucagonGIPHomo sapiens--3.132023-10-18doi.org/10.1073/pnas.2306145120
7DTYB1PeptideGlucagonGIPHomo sapiensGIP-Gs/β1/γ22.982021-08-04doi.org/10.7554/eLife.68719
7DTY (No Gprot) B1PeptideGlucagonGIPHomo sapiensGIP-2.982021-08-04doi.org/10.7554/eLife.68719
8YW4B1PeptideGlucagonGIPHomo sapiensRetatrutide-chim(NtGi1-Gs)/β1/γ23.262024-09-18doi.org/10.1038/s41421-024-00700-0
8YW4 (No Gprot) B1PeptideGlucagonGIPHomo sapiensRetatrutide-3.262024-09-18doi.org/10.1038/s41421-024-00700-0
9IVGB1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ232024-11-27doi.org/10.1016/j.apsb.2024.09.002
9IVG (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)-32024-11-27doi.org/10.1016/j.apsb.2024.09.002
7RTBB1PeptideGlucagonGLP-1Homo sapiensPeptide-19-Gs/β1/γ22.142021-10-06doi.org/10.1016/j.bbrc.2021.09.016
7RTB (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPeptide-19-2.142021-10-06doi.org/10.1016/j.bbrc.2021.09.016
7KI0B1PeptideGlucagonGLP-1Homo sapiensSemaglutide-Gs/β1/γ22.52021-08-04doi.org/10.1016/j.celrep.2021.109374
7KI0 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensSemaglutide-2.52021-08-04doi.org/10.1016/j.celrep.2021.109374
7KI1B1PeptideGlucagonGLP-1Homo sapiensTaspoglutide-Gs/β1/γ22.52021-08-04doi.org/10.1016/j.celrep.2021.109374
7KI1 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTaspoglutide-2.52021-08-04doi.org/10.1016/j.celrep.2021.109374
6X18B1PeptideGlucagonGLP-1Homo sapiensGLP-1-Gs/β1/γ22.12020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X18 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1-2.12020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X19B1PeptideGlucagonGLP-1Homo sapiensCHU-128-Gs/β1/γ22.12020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X19 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensCHU-128-2.12020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X1AB1PeptideGlucagonGLP-1Homo sapiensDanuglipron-Gs/β1/γ22.52020-09-09doi.org/10.1016/j.molcel.2020.09.020
6X1A (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensDanuglipron-2.52020-09-09doi.org/10.1016/j.molcel.2020.09.020
7LCIB1PeptideGlucagonGLP-1Homo sapiensDanuglipron-Gs/β1/γ22.92021-01-20doi.org/10.1016/j.str.2021.04.008
7LCI (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensDanuglipron-2.92021-01-20doi.org/10.1016/j.str.2021.04.008
7LCJB1PeptideGlucagonGLP-1Homo sapiensDanuglipron--2.822021-01-20doi.org/10.1016/j.str.2021.04.008
7LCKB1PeptideGlucagonGLP-1Homo sapiensDanuglipron--3.242021-01-20doi.org/10.1016/j.str.2021.04.008
7S15B1PeptideGlucagonGLP-1Homo sapiensPubChem 134611223--3.82022-06-08doi.org/10.1021/acs.jmedchem.1c01856
9J1PB1PeptideGlucagonGLP-1Homo sapiensg1:Ox-chim(NtGi1-Gs)/β1/γ22.992025-02-26doi.org/10.1021/jacs.4c12808
9J1P (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensg1:Ox-2.992025-02-26doi.org/10.1021/jacs.4c12808
5VAIB1PeptideGlucagonGLP-1Oryctolagus cuniculusGLP-1-Gs/β1/γ24.12017-05-24doi.org/10.1038/nature22394
5VAI (No Gprot) B1PeptideGlucagonGLP-1Oryctolagus cuniculusGLP-1-4.12017-05-24doi.org/10.1038/nature22394
5NX2B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (Truncated)--3.72017-06-14doi.org/10.1038/nature22800
6B3JB1PeptideGlucagonGLP-1Homo sapiensExendin-P5-Gs/β1/γ23.32018-02-21doi.org/10.1038/nature25773
6B3J (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-P5-3.32018-02-21doi.org/10.1038/nature25773
8WG7B1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ22.542024-03-06doi.org/10.1038/s41421-024-00649-0
8WG7 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--2.542024-03-06doi.org/10.1038/s41421-024-00649-0
7C2EB1PeptideGlucagonGLP-1Homo sapiensPubChem 149050799-Gs/β1/γ24.22020-08-26doi.org/10.1038/s41422-020-0384-8
7C2E (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPubChem 149050799-4.22020-08-26doi.org/10.1038/s41422-020-0384-8
7LLLB1PeptideGlucagonGLP-1Homo sapiensExendin-4-Gs/β1/γ23.72022-01-12doi.org/10.1038/s41467-021-27760-0
7LLL (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-4-3.72022-01-12doi.org/10.1038/s41467-021-27760-0
7LLYB1PeptideGlucagonGLP-1Homo sapiensOxyntomodulin-Gs/β1/γ23.32022-01-12doi.org/10.1038/s41467-021-27760-0
7LLY (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensOxyntomodulin-3.32022-01-12doi.org/10.1038/s41467-021-27760-0
7FIMB1PeptideGlucagonGLP-1Homo sapiensTirzepatide-Gs/β1/γ23.42022-03-02doi.org/10.1038/s41467-022-28683-0
7FIM (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTirzepatide-3.42022-03-02doi.org/10.1038/s41467-022-28683-0
7VBIB1PeptideGlucagonGLP-1Homo sapiensNon-Acylated Tirzepatide-Gs/β1/γ232022-03-02doi.org/10.1038/s41467-022-28683-0
7VBI (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensNon-Acylated Tirzepatide-32022-03-02doi.org/10.1038/s41467-022-28683-0
7VBHB1PeptideGlucagonGLP-1Homo sapiensPeptide-20-Gs/β1/γ232022-04-06doi.org/10.1038/s41467-022-28683-0
7VBH (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPeptide-20-32022-04-06doi.org/10.1038/s41467-022-28683-0
7S1MB1PeptideGlucagonGLP-1Homo sapiensEx4-D-Ala-Gs/β1/γ22.412022-01-05doi.org/10.1038/s41589-021-00945-w
7S1M (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensEx4-D-Ala-2.412022-01-05doi.org/10.1038/s41589-021-00945-w
7S3IB1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ22.512022-01-05doi.org/10.1038/s41589-021-00945-w
7S3I (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--2.512022-01-05doi.org/10.1038/s41589-021-00945-w
6XOXB1PeptideGlucagonGLP-1Homo sapiensOrforglipron-chim(NtGi1-Gs)/β1/γ23.12020-11-18doi.org/10.1073/pnas.2014879117
6XOX (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensOrforglipron-3.12020-11-18doi.org/10.1073/pnas.2014879117
7RG9B1PeptideGlucagonGLP-1Homo sapiens--chim(NtGi1-Gs)/β1/γ23.22022-04-13doi.org/10.1073/pnas.2116506119
7RG9 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--3.22022-04-13doi.org/10.1073/pnas.2116506119
7RGPB1PeptideGlucagonGLP-1Homo sapiensTirzepatide-chim(NtGi1-Gs)/β1/γ22.92022-04-13doi.org/10.1073/pnas.2116506119
7RGP (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensTirzepatide-2.92022-04-13doi.org/10.1073/pnas.2116506119
7X8RB1PeptideGlucagonGLP-1Homo sapiensBOC5-Gs/β1/γ22.612022-06-29doi.org/10.1073/pnas.2200155119
7X8R (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensBOC5-2.612022-06-29doi.org/10.1073/pnas.2200155119
7X8SB1PeptideGlucagonGLP-1Homo sapiensWB4-24-Gs/β1/γ23.092022-06-29doi.org/10.1073/pnas.2200155119
7X8S (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensWB4-24-3.092022-06-29doi.org/10.1073/pnas.2200155119
8JIPB1PeptideGlucagonGLP-1Homo sapiensMEDI0382-chim(NtGi1-Gs)/β1/γ22.852023-09-06doi.org/10.1073/pnas.2303696120
8JIP (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensMEDI0382-2.852023-09-06doi.org/10.1073/pnas.2303696120
8JIRB1PeptideGlucagonGLP-1Homo sapiensSAR425899-chim(NtGi1-Gs)/β1/γ22.572023-09-06doi.org/10.1073/pnas.2303696120
8JIR (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensSAR425899-2.572023-09-06doi.org/10.1073/pnas.2303696120
8JISB1PeptideGlucagonGLP-1Homo sapiensPeptide-15-chim(NtGi1-Gs)/β1/γ22.462023-11-08doi.org/10.1073/pnas.2303696120
8JIS (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensPeptide-15-2.462023-11-08doi.org/10.1073/pnas.2303696120
8YW3B1PeptideGlucagonGLP-1Homo sapiensRetatrutide-Gs/β1/γ22.682024-09-18doi.org/10.1038/s41421-024-00700-0
8YW3 (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensRetatrutide-2.682024-09-18doi.org/10.1038/s41421-024-00700-0
9EBNB1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ23.442025-03-26doi.org/10.1073/pnas.2407574122
9EBN (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--3.442025-03-26doi.org/10.1073/pnas.2407574122
9EBOB1PeptideGlucagonGLP-1Homo sapiensGLP-1 (ACPC18)-Gs/β1/γ23.132025-03-26doi.org/10.1073/pnas.2407574122
9EBO (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensGLP-1 (ACPC18)-3.132025-03-26doi.org/10.1073/pnas.2407574122
9EBQB1PeptideGlucagonGLP-1Homo sapiens--Gs/β1/γ23.162025-03-26doi.org/10.1073/pnas.2407574122
9EBQ (No Gprot) B1PeptideGlucagonGLP-1Homo sapiens--3.162025-03-26doi.org/10.1073/pnas.2407574122
8YWFB1PeptideGlucagonGLP-1Homo sapiensRetatrutide-chim(NtGi1-Gs)/β1/γ22.742025-04-16To be published
8YWF (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensRetatrutide-2.742025-04-16To be published
9BYOB1PeptideGlucagonGLP-1Homo sapiensExendin-3-Gs/β1/γ22.312025-06-11To be published
9BYO (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-3-2.312025-06-11To be published
9C0KB1PeptideGlucagonGLP-1Homo sapiensExendin-4-Gs/β1/γ22.722025-06-11To be published
9C0K (No Gprot) B1PeptideGlucagonGLP-1Homo sapiensExendin-4-2.722025-06-11To be published
7D68B1PeptideGlucagonGLP-2Homo sapiensGLP-2-Gs/β1/γ232020-12-16doi.org/10.1038/s41422-020-00442-0
7D68 (No Gprot) B1PeptideGlucagonGLP-2Homo sapiensGLP-2-32020-12-16doi.org/10.1038/s41422-020-00442-0
8FU6B1PeptideGlucagonGlucagonHomo sapiensGlucagon derivative ZP3780-Gs/β1/γ22.92023-04-12doi.org/10.1016/j.cell.2023.02.028
8FU6 (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensGlucagon derivative ZP3780-2.92023-04-12doi.org/10.1016/j.cell.2023.02.028
4L6RB1PeptideGlucagonGlucagonHomo sapiens---3.32013-07-24doi.org/10.1038/nature12393
5YQZB1PeptideGlucagonGlucagonHomo sapiensGlucagon analogue--32018-01-17doi.org/10.1038/nature25153
7V35B1PeptideGlucagonGlucagonHomo sapiensPeptide-20-Gs/β1/γ23.52022-03-02doi.org/10.1038/s41467-022-28683-0
7V35 (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensPeptide-20-3.52022-03-02doi.org/10.1038/s41467-022-28683-0
8JRUB1PeptideGlucagonGlucagonHomo sapiens--Arrestin23.52023-08-16doi.org/10.1038/s41586-023-06420-x
8JRVB1PeptideGlucagonGlucagonHomo sapiensGlucagon-Arrestin23.32023-08-16doi.org/10.1038/s41586-023-06420-x
8JITB1PeptideGlucagonGlucagonHomo sapiensMEDI0382-Gs/β1/γ22.912023-09-06doi.org/10.1073/pnas.2303696120
8JIT (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensMEDI0382-2.912023-09-06doi.org/10.1073/pnas.2303696120
8JIQB1PeptideGlucagonGlucagonHomo sapiensPeptide-15-Gs/β1/γ23.42023-09-13doi.org/10.1073/pnas.2303696120
8JIQ (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensPeptide-15-3.42023-09-13doi.org/10.1073/pnas.2303696120
8JIUB1PeptideGlucagonGlucagonHomo sapiensSAR425899-Gs/β1/γ22.762023-09-13doi.org/10.1073/pnas.2303696120
8JIU (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensSAR425899-2.762023-09-13doi.org/10.1073/pnas.2303696120
6WHCB1PeptideGlucagonGlucagonHomo sapiensGlu16 analog of GCG-Gs/β1/γ23.42020-05-27doi.org/10.1074/jbc.RA120.013793
6WHC (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensGlu16 analog of GCG-3.42020-05-27doi.org/10.1074/jbc.RA120.013793
6LMKB1PeptideGlucagonGlucagonHomo sapiensGlucagon-Gs/β1/γ23.72020-04-01doi.org/10.1126/science.aaz5346
6LMK (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensGlucagon-3.72020-04-01doi.org/10.1126/science.aaz5346
6LMLB1PeptideGlucagonGlucagonHomo sapiensGlucagon-Gi1/β1/γ13.92020-04-01doi.org/10.1126/science.aaz5346
6LML (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensGlucagon-3.92020-04-01doi.org/10.1126/science.aaz5346
6WPWB1PeptideGlucagonGlucagonHomo sapiensGlucagon derivative ZP3780-Gs/β1/γ23.12020-08-12doi.org/10.1126/science.aba3373
6WPW (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensGlucagon derivative ZP3780-3.12020-08-12doi.org/10.1126/science.aba3373
8YW5B1PeptideGlucagonGlucagonHomo sapiensRetatrutide-Gs/β1/γ22.842024-09-18doi.org/10.1038/s41421-024-00700-0
8YW5 (No Gprot) B1PeptideGlucagonGlucagonHomo sapiensRetatrutide-2.842024-09-18doi.org/10.1038/s41421-024-00700-0
7D3SB1PeptideGlucagonSecretinHomo sapiensSecretin-Gs/β1/γ22.92020-11-04doi.org/10.1016/j.bbrc.2020.08.042
7D3S (No Gprot) B1PeptideGlucagonSecretinHomo sapiensSecretin-2.92020-11-04doi.org/10.1016/j.bbrc.2020.08.042
6WI9B1PeptideGlucagonSecretinHomo sapiensSecretin-Gs/β1/γ24.32020-08-12doi.org/10.1038/s41467-020-17791-4
6WI9 (No Gprot) B1PeptideGlucagonSecretinHomo sapiensSecretin-4.32020-08-12doi.org/10.1038/s41467-020-17791-4
6WZGB1PeptideGlucagonSecretinHomo sapiensSecretin-Gs/β1/γ22.32020-08-12doi.org/10.1038/s41467-020-17791-4
6WZG (No Gprot) B1PeptideGlucagonSecretinHomo sapiensSecretin-2.32020-08-12doi.org/10.1038/s41467-020-17791-4




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