Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:H41 3.88556
2A:A:F219 5.33458
3A:A:H220 6.27254167
4A:A:F222 6.23754167
5A:A:K233 3.33549
6A:A:F238 4.122509
7A:A:Y253 4.9375408
8A:A:F290 3.725409
9A:A:L291 2.765408
10A:A:N292 2.5725409
11A:A:D295 3.174179
12A:A:F312 3.165408
13A:A:F315 6.75406
14A:A:Y318 4.626506
15A:A:K338 5.636595
16A:A:Y339 3.665403
17A:A:F340 8.5075407
18A:A:R342 4.4785184
19A:A:F345 4.7275408
20A:A:L346 3.37754184
21A:A:F376 3.964558
22A:A:R380 3.055457
23A:A:R385 5.9325195
24B:B:D27 3.275408
25B:B:I37 3.762502
26B:B:R52 3.3925417
27B:B:H54 5.76509
28B:B:K57 6.376519
29B:B:W63 3.73333607
30B:B:D76 5.65754229
31B:B:W82 5.8085149
32B:B:Y85 8.8975484
33B:B:N88 2.9675407
34B:B:K89 4.466149
35B:B:I93 3.3175407
36B:B:L95 3.21754248
37B:B:W99 5.016509
38B:B:Y111 4.6825404
39B:B:C121 3.4754118
40B:B:Y145 3.662548
41B:B:L146 3.8154117
42B:B:C149 3.775118
43B:B:F151 1.9825409
44B:B:I157 2.32754117
45B:B:T159 4.61254119
46B:B:S160 2.584536
47B:B:S161 6.51409
48B:B:D163 4.76754259
49B:B:W169 8.7625408
50B:B:T178 2.625434
51B:B:F180 4.954537
52B:B:H183 6.19539
53B:B:D186 3.1575449
54B:B:C204 4.34447
55B:B:K209 7.845436
56B:B:W211 6.62667638
57B:B:D212 5.2275409
58B:B:C218 3.455435
59B:B:Q220 8.0625427
60B:B:F222 5.68428
61B:B:H225 5.92833629
62B:B:D228 7.3449
63B:B:I232 3.6225428
64B:B:F235 6.2445126
65B:B:N237 3.115405
66B:B:F241 4.976526
67B:B:T243 3.6125428
68B:B:D246 3.8275449
69B:B:T249 4.185426
70B:B:R251 6.806528
71B:B:F253 4.065426
72B:B:D254 4.0075409
73B:B:D258 8.3427
74B:B:Q259 3.618506
75B:B:Y264 2.845405
76B:B:C271 3.075465
77B:B:G272 1.77404
78B:B:T274 2.625418
79B:B:F278 5.394127
80B:B:R283 3.68754109
81B:B:L284 3.9975405
82B:B:G288 1.87417
83B:B:Y289 4.89667667
84B:B:D290 4.38416
85B:B:D298 6.44109
86B:B:L300 2.44406
87B:B:R304 4.675465
88B:B:H311 7.058519
89B:B:R314 6.80833618
90B:B:C317 2.14407
91B:B:T321 4.44254237
92B:B:T329 4.42408
93B:B:W332 8.708519
94B:B:K337 4.3825416
95B:B:W339 4.4525419
96G:G:V16 3.364217
97G:G:K20 3.55254216
98G:G:R27 5.57408
99G:G:D48 4.934509
100G:G:L51 3.37406
101G:G:F61 3.59167688
102R:R:N22 3.892509
103R:R:L32 2.96607
104R:R:K35 1.3175416
105R:R:F43 3.07408
106R:R:L47 2.6525409
107R:R:I54 3.2225408
108R:R:T100 3.295478
109R:R:P110 3.5075408
110R:R:F111 5.3175457
111R:R:S118 3.37754158
112R:R:W130 4.9875409
113R:R:F146 7.93754282
114R:R:Y151 4.224134
115R:R:F165 4.9775406
116R:R:F181 5.002578
117R:R:F184 3.724506
118R:R:Y185 4.58667679
119R:R:V227 3.835408
120R:R:F234 5.146579
121R:R:W238 12.238578
122R:R:I278 3.9875408
123R:R:Y279 4.315609
124R:R:W282 3.1575407
125R:R:Q289 4.38407
126W:W:?1 3.14600
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:H54 B:B:I58 12.34593.98YesNo099
2B:B:C317 B:B:I58 14.08391.64YesNo079
3B:B:C317 B:B:S316 41.15611.72YesNo079
4B:B:S316 B:B:W332 41.39994.94NoYes099
5B:B:K57 B:B:W332 88.950610.44YesYes199
6B:B:K57 B:B:Y59 42.02893.58YesNo198
7A:A:C237 B:B:Y59 42.03334.03NoNo088
8A:A:C237 A:A:F238 42.08292.79NoYes089
9A:A:F238 A:A:W234 99.99572YesNo099
10A:A:R231 A:A:W234 1004NoNo099
11A:A:I276 A:A:R231 99.69253.76NoNo089
12A:A:F246 A:A:I276 99.53572.51NoNo098
13A:A:F246 A:A:L289 91.70883.65NoNo099
14A:A:F345 A:A:L289 91.53793.65YesNo089
15A:A:F345 A:A:L266 89.45962.44YesNo088
16A:A:F312 A:A:L266 89.28624.87YesNo088
17A:A:F312 A:A:Y311 82.95222.06YesNo086
18A:A:Y253 A:A:Y311 82.37362.98YesNo086
19A:A:K300 A:A:Y253 87.97463.58NoYes098
20A:A:K300 A:A:S251 86.42033.06NoNo099
21A:A:L296 A:A:S251 86.19626.01NoNo069
22A:A:D295 A:A:L296 85.67315.43YesNo1796
23A:A:C365 A:A:D295 85.29473.11NoYes089
24A:A:C365 A:A:D368 85.06813.11NoNo089
25A:A:D368 A:A:R374 84.84094.76NoNo094
26A:A:H362 A:A:R374 82.3154.51NoNo094
27A:A:D378 A:A:H362 78.79146.3NoNo079
28A:A:D378 A:A:Y360 78.35146.9NoNo078
29A:A:R385 A:A:Y360 77.75766.17YesNo058
30A:A:R385 R:R:H195 76.52339.03YesNo058
31A:A:Q384 R:R:H195 76.0264.95NoNo068
32A:A:Q384 R:R:P110 75.77664.74NoYes068
33A:A:I383 R:R:P110 68.25593.39NoYes088
34A:A:H387 A:A:I383 66.93642.65NoNo088
35A:A:H387 R:R:A106 66.67112.93NoNo089
36R:R:A106 R:R:Y113 66.40535.34NoNo099
37B:B:K57 B:B:Q75 47.49169.49YesNo199
38B:B:Q75 B:B:W99 47.58734.38NoYes099
39A:A:F238 B:B:W99 60.36177.02YesYes099
40B:B:L117 B:B:W99 21.94613.42NoYes099
41A:A:Q227 B:B:L117 21.84333.99NoNo099
42A:A:Q227 B:B:Y145 21.76943.38NoYes098
43B:B:D186 B:B:G185 15.19851.68YesNo095
44B:B:C204 B:B:D186 10.53634.67YesYes479
45B:B:C204 B:B:D228 10.50896.22YesYes479
46B:B:D228 B:B:D246 17.67486.65YesYes499
47B:B:D246 B:B:G272 17.61851.68YesYes094
48B:B:D290 B:B:G272 44.77641.68YesYes064
49B:B:D290 B:B:R314 32.863110.72YesYes168
50B:B:R314 B:B:W332 57.248117.99YesYes189
51A:A:F312 A:A:F340 12.32954.29YesYes087
52A:A:F340 A:A:Y318 12.58846.19YesYes076
53R:R:D102 R:R:Y113 63.99023.45NoNo099
54R:R:D102 R:R:F43 63.44782.39NoYes098
55R:R:F43 R:R:I99 62.08312.51YesNo089
56R:R:I99 R:R:L47 61.80861.43NoYes099
57R:R:L47 R:R:Y279 49.52153.52YesYes099
58R:R:R103 R:R:Y279 12.22542.06NoYes099
59R:R:R103 R:R:Y185 10.90133.09NoYes099
60R:R:V227 R:R:Y185 10.46416.31YesYes089
61R:R:L230 R:R:Y279 12.56213.52NoYes089
62R:R:L230 R:R:Y185 10.9973.52NoYes089
63B:B:G185 B:B:T184 13.97951.82NoNo053
64B:B:D205 B:B:T184 13.73425.78NoNo093
65B:B:A203 B:B:D205 13.2423.09NoNo089
66B:B:A203 B:B:H183 12.99528.78NoYes089
67B:B:G272 B:B:I273 34.93131.76YesNo046
68B:B:C250 B:B:I273 29.69681.64NoNo086
69B:B:C250 B:B:Y264 29.37324.03NoYes085
70B:B:L252 B:B:Y264 13.99572.34NoYes075
71B:B:L252 B:B:L261 13.65544.15NoNo075
72B:B:D254 B:B:L261 13.31622.71YesNo095
73B:B:A257 B:B:D254 11.96144.63NoYes079
74B:B:A257 B:B:Q259 11.62274.55NoYes076
75B:B:G330 B:B:T329 11.66421.82NoYes058
76B:B:L318 B:B:S277 11.98623NoNo065
77B:B:S277 B:B:V320 11.64834.85NoNo057
78B:B:V320 B:B:V327 11.31273.21NoNo076
79B:B:L286 B:B:V327 10.98192.98NoNo076
80B:B:L286 B:B:V296 10.6572.98NoNo075
81B:B:L284 B:B:V296 10.352.98YesNo055
82B:B:D333 B:B:H311 17.84343.78NoYes199
83B:B:D333 B:B:F335 26.69848.36NoNo194
84B:B:C317 B:B:M61 16.99023.24YesNo076
85B:B:M61 B:B:W63 16.68993.49NoYes067
86B:B:G162 B:B:Y145 13.40014.35NoYes498
87B:B:G162 B:B:S161 18.98761.86NoYes099
88B:B:L146 B:B:S161 12.77084.5YesYes079
89B:B:L285 B:B:Y264 12.94962.34NoYes065
90B:B:F278 B:B:L285 12.2647.31YesNo076
91B:B:L318 B:B:S275 12.18814.5NoNo068
92B:B:R314 B:B:T274 23.84992.59YesYes188
93B:B:S275 B:B:T274 12.38173.2NoYes188
94B:B:H311 B:B:V315 11.46872.77YesNo197
95B:B:G288 B:B:V315 21.77881.84YesNo177
96R:R:D51 R:R:L47 10.22832.71NoYes099
97B:B:F335 R:R:K35 24.0411.24NoYes146
98R:R:K35 R:R:L32 22.33881.41YesYes067
99R:R:V96 R:R:Y279 19.7092.52NoYes099
100R:R:F234 R:R:V96 19.38523.93YesNo099
101R:R:F234 R:R:W238 17.36689.02YesYes798
102R:R:T239 R:R:W238 15.8934.85NoYes048
103R:R:P240 R:R:T239 15.19213.5NoNo094
104R:R:L264 R:R:P240 14.84091.64NoNo049
105R:R:L264 R:R:T244 14.48914.42NoNo044
106R:R:Q248 R:R:T244 14.13694.25NoNo034
107R:R:F158 R:R:Q248 13.430818.74NoNo033
108R:R:F158 R:R:W265 13.0773.01NoNo033
109R:R:F241 R:R:W265 12.36793.01NoNo063
110R:R:F157 R:R:F241 11.65672.14NoNo046
111R:R:F157 R:R:T86 11.30042.59NoNo045
112R:R:G137 R:R:T86 10.94351.82NoNo075
113R:R:G137 R:R:P140 10.22834.06NoNo075
114B:B:S84 B:B:W63 14.00543.71NoYes057
115B:B:C317 B:B:G330 12.47231.96YesNo075
116B:B:G288 B:B:T274 23.14361.82YesYes178
117B:B:S331 B:B:V315 10.04614.85NoNo197
118B:B:D290 B:B:T274 11.96912.89YesYes168
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:R225 W:W:?1 1.73 0 No Yes 6 0 1 0
R:R:V229 W:W:?1 9.22 0 No Yes 7 0 1 0
R:R:G232 W:W:?1 2.44 0 No Yes 5 0 1 0
R:R:L274 R:R:S233 3 0 No No 5 7 1 2
R:R:I278 R:R:S233 3.1 0 Yes No 8 7 1 2
R:R:L274 W:W:?1 1.98 0 No Yes 5 0 1 0
R:R:I278 R:R:Y279 8.46 0 Yes Yes 8 9 1 2
R:R:I278 R:R:W282 2.35 0 Yes Yes 8 7 1 2
R:R:I278 W:W:?1 2.04 0 Yes Yes 8 0 1 0
R:R:S228 W:W:?1 1.43 0 No Yes 7 0 1 0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
40.00Single7CA3rac-BHFF7CA3-GABAB1, GABAB2-rac-BHFF
36.36Single7C7QBHFF7C7Q-GABAB1, GABAB2-Baclofen-BHFF
36.36Single9L8LAtazanavir9L8L-β2-BI167107-Atazanavir-Gs/β1/γ2 ; Arrestin2
33.33Single5XEZNNC06405XEZ-Glucagon-NNC0640
33.33Single7EB2rac-BHFF7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
30.77Single5XF1NNC06405XF1-Glucagon-NNC0640
27.27Single5VEXNNC06405VEX-GLP-1-NNC0640
25.00Single5VEWPF-063722225VEW-GLP-1-PF-06372222
25.00Single6UO8GS397836UO8-GABAB1, GABAB2-SKF97541-GS39783
23.53Single6LN2PF-063722226LN2-GLP-1-PF-06372222
23.08Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
22.22Single9L84Atazanavir9L84-β1-Epinephrine-Atazanavir-Gs/β1/γ2
18.18Single5EE7MK08935EE7-Glucagon-MK0893
17.65Single8JR9PCO3718JR9-PTH1-PCO371-chim(NtGi1-Gs)/β1/γ2
16.67Single6KK7PF-063722226KK7-GLP-1-PF-06372222
16.67Single9DYDPtdIns4P9DYD-5-HT1A-Asenapine-PtdIns4P-Go/β1/γ2
15.38Single6KJVPF-063722226KJV-GLP-1-PF-06372222
15.38Single6KK1PF-063722226KK1-GLP-1-PF-06372222
15.38Single8XQNAristolochic acid A8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
15.38Single9CLW4-CMTB9CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.38Single9DYEPtdIns4P9DYE-5-HT1A-Buspirone-PtdIns4P-Go/β1/γ2
15.38Single9MD1PtdIns4P9MD1-5-HT1A-Buspirone-PtdIns4P-Gz/β1/γ2
14.29Single7E14PubChem 1560227387E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
14.29Single8XQOAristolochic acid A8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
14.29Single8XQSFlufenamic acid8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
14.29Single9KVHPtdIns4P9KVH-5-HT1A-Cinobufotenine-PtdIns4P-Gi1/β1/γ2
13.33Single7E2XPtdIns4P7E2X-5-HT1A-PtdIns4P-Gi1/β1/γ2
13.33Single7E2YPtdIns4P7E2Y-5-HT1A-Serotonin-PtdIns4P-Gi1/β1/γ2
13.33Single7RBTLSN35566727RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
13.33Single8FYEPtdIns4P8FYE-5-HT1A-4-F,5-MeO-PyrT-PtdIns4P-Gi1/β1/γ1
13.33Single8FYTPtdIns4P8FYT-5-HT1A-LSD-PtdIns4P-Gi1/β1/γ1
13.33Single8XQLAristolochic acid A8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
13.33Single9KVGPtdIns4P9KVG-5-HT1A-5-MeO-DMT-PtdIns4P-Gi1/β1/γ2
12.50Single8FY8PtdIns4P8FY8-5-HT1A-5-MeO-DMT-PtdIns4P-Gi1/β1/γ1
12.50Single8FYLPtdIns4P8FYL-5-HT1A-Vilazodone-PtdIns4P-Gi1/β1/γ1
12.50Single8FYXPtdIns4P8FYX-5-HT1A-Buspirone-PtdIns4P-Gi1/β1/γ1
12.50Single8GW8PCO3718GW8-PTH1-PCO371-Gs/β1/γ2
11.76Single8J20AR4206268J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
11.11Single7DUQPubChem 1560227387DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
11.11Single8TB7PubChem 1685102188TB7-GPR61-PubChem 168510218
11.11Single9DYFPtdIns4P9DYF-5-HT1A-Asenapine-PtdIns4P-Gi1/β1/γ2
8.33Single8JT6PtdIns4P8JT6-5-HT1A-(R)-IHCH-7179-PtdIns4P-Gi1/β1/γ2
8.33Single8XQPAristolochic acid A8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
8.33Single8Y6W4-CMTB8Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
7.69Single7LD3MIPS5217LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
7.69Single8HNNSCH5467388HNN-CXCR3-SCH546738
7.14Single7EJX(1R;2R)-2-PCCA7EJX-GPR88-(1R;2R)-2-PCCA-Gi1/β1/γ2
7.14Single8XQRFlufenamic acid8XQR-TAS2R14-Flufenamic acid-Gt3/β1/γ1
6.25Single7E2ZPtdIns4P7E2Z-5-HT1A-Aripiprazole-PtdIns4P-Gi1/β1/γ2
4.55Single8ZYTSBI-5538ZYT-NTS1-Neurotensin-(8-13)-SBI-553-Arrestin2

PDB Summary
PDB 9L80
Class A
SubFamily Lipid
Type GPR119
SubType GPR119
Species Homo Sapiens
Ligand -
Other Ligand(s) Atazanavir
Protein Partners chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution 3.33
Date 2025-12-31
D.O.I. To be published
Net Summary
Imin 1.64
Number of Linked Nodes 806
Number of Links 908
Number of Hubs 126
Number of Links mediated by Hubs 459
Number of Communities 30
Number of Nodes involved in Communities 162
Number of Links involved in Communities 207
Path Summary
Number Of Nodes in MetaPath 119
Number Of Links MetaPath 118
Number of Shortest Paths 675079
Length Of Smallest Path 3
Average Path Length 33.0987
Length of Longest Path 78
Minimum Path Strength 1.225
Average Path Strength 4.33926
Maximum Path Strength 21.19
Minimum Path Correlation 0.7
Average Path Correlation 0.976924
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.92308
Average % Of Corr. Nodes 45.407
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 39.2598
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeDR7
PDB ResiduesW:W:?1
Environment DetailsOpen EMBL-EBI Page
CodeDR7
NameAtazanavir
SynonymsATAZANAVIR; METHYL [(1S,4S,5S,10S)-4-BENZYL-1,10-DI-TERT-BUTYL-5-HYDROXY-2,9,12-TRIOXO-7-(4-PYRIDIN-2-YLBENZYL)-13-OXA-3,7,8,11-TETRAAZATETRADEC-1-YL]CARBAMATE
Identifier
FormulaC38 H52 N6 O7
Molecular Weight704.855
SMILES
PubChem148192
Formal Charge0
Total Atoms103
Total Chiral Atoms4
Total Bonds105
Total Aromatic Bonds19

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>9L80_Chain_A
EKAEKIEKQ LQKDKQVYR ATHRLLLLG ADNSGKSTI VGIFETKFQ 
VDKVNFHMF DVGGQRDER RKWIQCFND VTAIIFVVD SSDYNRLQE 
ALNDFKSIW NNRWLRTIS VILFLNKQD LLAEKVLAG KSKIEDYFP 
EFARYTTPE DATPEPGED PRVTRAKYF IRDEFLRIS TASGDGRHY 
CYPHFTCAV DTENARRIF NDCRDIIQR MHLRQYELL SADAVRSM


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP54311
Sequence
>9L80_Chain_B
DQLRQEAEQ LKNQIRDAR KACADATLS QITNNIDPV GRIQMRTRR 
TLRGHLAKI YAMHWGTDS RLLVSASQD GKLIIWDSY TTNKVHAIP 
LRSSWVMTC AYAPSGNYV ACGGLDNIC SIYNLKTRE GNVRVSREL 
AGHTGYLSC CRFLDDNQI VTSSGDTTC ALWDIETGQ QTTTFTGHT 
GDVMSLSLA PDTRLFVSG ACDASAKLW DVREGMCRQ TFTGHESDI 
NAICFFPNG NAFATGSDD ATCRLFDLR ADQELMTYS HDNIICGIT 
SVSFSKSGR LLLAGYDDF NCNVWDALK ADRAGVLAG HDNRVSCLG 
VTDDGMAVA TGSWDSFLK IWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP63212
Sequence
>9L80_Chain_G
SIAQARKLV EQLKMEANI DRIKVSKAA ADLMAYCEA HAKEDPLLT 
PVPASENPF R


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ8TDV5
Sequence
>9L80_Chain_R
GVILAVLAS LIIATNTLV AVAVLLLIH KNDGVSLCF TLNLAVADT 
LIGVAISGL LTDQLSKTL CSLRMAFVT SSAAASVLT VMLITFDRY 
LAIKQPFRY LKIMSGFVA GACIAGLWL VSYLIGFLP LGIPMFQQT 
AYKGQCSFF AVFHPHFVL TLSCVGFFP AMLLFVFFY CDMLKIASM 
HSQQIRKME HAGAMAPSD FKALRTVSV LIGSFALSW TPFLITGIV 
QVERYLWLL GVGNSLLNP LIYAYWQKE VRLQLYHMA LG


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7XZ5ALipidGPR119GPR119Homo sapiensLysophosphatidylcholine-Gs/β1/γ23.12022-08-24doi.org/10.1038/s41594-022-00816-5
7XZ5 (No Gprot) ALipidGPR119GPR119Homo sapiensLysophosphatidylcholine-3.12022-08-24doi.org/10.1038/s41594-022-00816-5
7XZ6ALipidGPR119GPR119Homo sapiensAPD668-Gs/β1/γ22.82022-08-24doi.org/10.1038/s41594-022-00816-5
7XZ6 (No Gprot) ALipidGPR119GPR119Homo sapiensAPD668-2.82022-08-24doi.org/10.1038/s41594-022-00816-5
7WCMALipidGPR119GPR119Homo sapiensMBX-2982-Gs/β1/γ22.332022-12-21doi.org/10.1038/s41467-022-34696-6
7WCM (No Gprot) ALipidGPR119GPR119Homo sapiensMBX-2982-2.332022-12-21doi.org/10.1038/s41467-022-34696-6
7WCNALipidGPR119GPR119Homo sapiensAR231453-Gs/β1/γ22.872022-12-21doi.org/10.1038/s41467-022-34696-6
7WCN (No Gprot) ALipidGPR119GPR119Homo sapiensAR231453-2.872022-12-21doi.org/10.1038/s41467-022-34696-6
8ZR5ALipidGPR119GPR119Homo sapiensFiruglipel-Gs/β1/γ23.312024-06-19To be published
8ZR5 (No Gprot) ALipidGPR119GPR119Homo sapiensFiruglipel-3.312024-06-19To be published
8ZRKALipidGPR119GPR119Homo sapiensGSK1292263-Gs/β1/γ22.822024-06-19To be published
8ZRK (No Gprot) ALipidGPR119GPR119Homo sapiensGSK1292263-2.822024-06-19To be published
8VHFALipidGPR119GPR119Homo sapiensMBX-2982-Gs/β1/γ23.512024-10-30doi.org/10.1016/j.str.2024.10.004
8VHF (No Gprot) ALipidGPR119GPR119Homo sapiensMBX-2982-3.512024-10-30doi.org/10.1016/j.str.2024.10.004
9L79ALipidGPR119GPR119Homo sapiensAR231453-chim(NtGi1-Gs)/β1/γ22.982025-12-31To be published
9L79 (No Gprot) ALipidGPR119GPR119Homo sapiensAR231453-2.982025-12-31To be published
9L80ALipidGPR119GPR119Homo sapiens-Atazanavirchim(NtGi1-Gs)/β1/γ23.332025-12-31To be published
9L80 (No Gprot) ALipidGPR119GPR119Homo sapiens-Atazanavir3.332025-12-31To be published




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Download 9L80.zip



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