psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F5	R:R:L66	3.65	No	No	0	4	5
2	R:R:F5	R:R:S67	5.28	No	No	0	4	5
3	R:R:F7	R:R:Q65	11.71	No	No	0	5	4
4	R:R:F7	R:R:R262	6.41	No	No	0	5	3
5	R:R:F7	R:R:L266	3.65	No	No	0	5	5
6	R:R:I10	R:R:L266	4.28	No	No	0	4	5
7	R:R:I58	R:R:L11	4.28	No	No	0	7	6
8	R:R:I18	R:R:L14	5.71	No	No	0	8	5
9	R:R:L14	R:R:V269	4.47	No	No	0	5	6
10	R:R:A15	R:R:I58	3.25	No	No	0	6	7
11	R:R:L17	R:R:L273	5.54	No	No	0	4	5
12	R:R:I18	R:R:S272	4.64	No	No	0	8	9
13	R:R:I18	R:R:L273	4.28	No	No	0	8	5
14	R:R:G55	R:R:I19	3.53	No	No	0	8	6
15	R:R:P276	R:R:T21	3.5	Yes	No	0	9	8
16	R:R:D51	R:R:N22	13.46	Yes	No	2	9	9
17	R:R:N22	R:R:P276	9.77	No	Yes	2	9	9
18	R:R:A280	R:R:V25	3.39	No	No	0	8	9
19	R:R:L45	R:R:V29	7.45	No	No	0	6	8
20	R:R:L30	R:R:L45	5.54	No	No	0	3	6
21	R:R:L31	R:R:Q289	5.32	No	Yes	0	5	7
22	R:R:L32	R:R:N36	4.12	Yes	No	3	7	9
23	R:R:E285	R:R:L32	3.98	No	Yes	3	6	7
24	R:R:L32	R:R:Q289	5.32	Yes	Yes	0	7	7
25	R:R:K35	R:R:N36	5.6	No	No	0	6	9
26	R:R:E285	R:R:N36	5.26	No	No	3	6	9
27	R:R:M117	R:R:V39	4.56	No	No	0	7	5
28	R:R:F43	R:R:L98	7.31	Yes	No	0	8	7
29	R:R:F43	R:R:I99	3.77	Yes	No	0	8	9
30	R:R:D102	R:R:F43	8.36	No	Yes	0	9	8
31	R:R:F43	R:R:I126	5.02	Yes	No	0	8	7
32	R:R:N46	R:R:T95	10.24	Yes	No	0	9	8
33	R:R:I126	R:R:N46	7.08	No	Yes	0	7	9
34	R:R:L129	R:R:N46	4.12	No	Yes	4	6	9
35	R:R:N46	R:R:W130	9.04	Yes	Yes	4	9	9
36	R:R:L47	R:R:T95	5.9	No	No	0	9	8
37	R:R:L47	R:R:N275	9.61	No	Yes	0	9	9
38	R:R:L47	R:R:Y279	3.52	No	Yes	0	9	9
39	R:R:D51	R:R:S92	4.42	Yes	No	0	9	9
40	R:R:D51	R:R:S272	8.83	Yes	No	0	9	9
41	R:R:D51	R:R:N275	4.04	Yes	Yes	0	9	9
42	R:R:D51	R:R:P276	3.22	Yes	Yes	2	9	9
43	R:R:L53	R:R:W130	3.42	No	Yes	0	8	9
44	R:R:G55	R:R:I54	3.53	No	No	0	8	8
45	R:R:I54	R:R:S88	6.19	No	No	0	8	6
46	R:R:I54	R:R:S272	9.29	No	No	0	8	9
47	L:L:?1	R:R:L61	4.4	Yes	No	0	0	5
48	R:R:D64	R:R:T63	5.78	No	No	0	4	5
49	R:R:D64	R:R:R81	9.53	No	No	0	4	6
50	R:R:P72	R:R:R71	7.21	No	No	0	3	6
51	R:R:L77	R:R:T73	4.42	No	No	0	4	5
52	R:R:K152	R:R:K75	10.06	No	No	0	1	3
53	R:R:C78	R:R:M82	3.24	No	No	0	9	5
54	R:R:C155	R:R:C78	7.28	No	No	0	9	9
55	R:R:S79	R:R:V160	6.46	No	No	0	4	5
56	R:R:C155	R:R:R81	5.57	No	No	0	9	6
57	R:R:F157	R:R:M82	6.22	Yes	No	1	4	5
58	R:R:F161	R:R:M82	6.22	Yes	No	1	4	5
59	R:R:A83	R:R:F138	8.32	No	No	0	6	4
60	R:R:F84	R:R:Y134	7.22	No	No	0	3	4
61	L:L:?1	R:R:V85	5.68	Yes	No	0	0	7
62	R:R:G137	R:R:T86	3.64	No	No	0	7	5
63	L:L:?1	R:R:T86	6.56	Yes	No	0	0	5
64	R:R:S87	R:R:Y134	12.72	No	No	0	5	4
65	R:R:G137	R:R:S87	3.71	No	No	0	7	5
66	L:L:?1	R:R:A89	5	Yes	No	0	0	6
67	R:R:A90	R:R:S133	3.42	No	No	0	7	8
68	R:R:A90	R:R:I136	3.25	No	No	0	7	6
69	R:R:A91	R:R:W130	3.89	No	Yes	0	7	9
70	R:R:A91	R:R:S133	3.42	No	No	0	7	8
71	L:L:?1	R:R:V93	6.63	Yes	No	0	0	7
72	R:R:F234	R:R:V96	5.24	Yes	No	0	9	9
73	R:R:N275	R:R:V96	4.43	Yes	No	0	9	9
74	R:R:V96	R:R:Y279	3.79	No	Yes	0	9	9
75	R:R:A177	R:R:M97	4.83	No	No	0	8	7
76	R:R:F181	R:R:M97	3.73	Yes	No	0	8	7
77	R:R:I99	R:R:Y279	3.63	No	Yes	0	9	9
78	R:R:F181	R:R:T100	9.08	Yes	No	5	8	8
79	R:R:F184	R:R:T100	3.89	Yes	No	0	6	8
80	R:R:T100	R:R:Y185	8.74	No	Yes	5	8	9
81	R:R:F101	R:R:L105	7.31	No	No	0	5	5
82	R:R:F101	R:R:F184	6.43	No	Yes	0	5	6
83	R:R:D102	R:R:Y113	8.05	No	No	0	9	9
84	R:R:R103	R:R:Y185	5.14	No	Yes	0	9	9
85	R:R:R103	R:R:Y279	5.14	No	Yes	0	9	9
86	R:R:K108	R:R:Y104	15.53	No	Yes	6	6	8
87	R:R:F184	R:R:Y104	17.54	Yes	Yes	0	6	8
88	R:R:D187	R:R:Y104	10.34	No	Yes	6	5	8
89	R:R:M188	R:R:Y104	3.59	No	Yes	0	9	8
90	R:R:A106	R:R:Y113	6.67	No	No	0	9	9
91	R:R:D187	R:R:K108	4.15	No	No	6	5	6
92	R:R:Q109	R:R:R112	10.51	No	No	0	5	5
93	R:R:M117	R:R:Y113	13.17	No	No	0	7	9
94	R:R:G119	R:R:S118	3.71	No	No	0	1	8
95	R:R:L129	R:R:W130	3.42	No	Yes	4	6	9
96	R:R:W130	R:R:Y134	5.79	Yes	No	0	9	4
97	R:R:F138	R:R:L141	3.65	No	No	0	4	6
98	R:R:L139	R:R:P140	4.93	No	Yes	0	4	5
99	R:R:I143	R:R:L139	4.28	No	No	0	4	4
100	R:R:F146	R:R:P140	4.33	No	Yes	1	2	5
101	R:R:F161	R:R:P140	10.11	Yes	Yes	1	4	5
102	R:R:F165	R:R:P140	11.56	No	Yes	1	6	5
103	R:R:I143	R:R:P144	3.39	No	No	0	4	2
104	R:R:F146	R:R:F165	8.57	No	No	1	2	6
105	R:R:H162	R:R:Q148	6.18	No	No	0	5	4
106	R:R:A159	R:R:S156	3.42	No	No	0	4	4
107	R:R:F157	R:R:F158	18.22	Yes	Yes	1	4	3
108	R:R:F157	R:R:F161	9.65	Yes	Yes	1	4	4
109	R:R:E261	R:R:F157	9.33	No	Yes	1	4	4
110	L:L:?1	R:R:F157	20.12	Yes	Yes	1	0	4
111	R:R:F158	R:R:V166	3.93	Yes	No	0	3	6
112	R:R:F158	R:R:L260	7.31	Yes	Yes	0	3	4
113	R:R:E261	R:R:F158	8.16	No	Yes	1	4	3
114	R:R:H162	R:R:P163	15.25	No	No	0	5	3
115	R:R:H162	R:R:H164	20.3	No	No	0	5	2
116	R:R:P163	R:R:V249	3.53	No	No	0	3	4
117	R:R:P163	R:R:Y257	9.74	No	No	0	3	4
118	R:R:H164	R:R:V249	4.15	No	No	0	2	4
119	R:R:F165	R:R:L169	6.09	No	No	0	6	6
120	R:R:F241	R:R:V166	5.24	Yes	No	0	6	6
121	L:L:?1	R:R:L169	4.4	Yes	No	0	0	6
122	R:R:F175	R:R:S170	6.61	No	No	0	5	6
123	R:R:L242	R:R:S170	6.01	No	No	0	6	6
124	R:R:I246	R:R:S170	6.19	No	No	0	5	6
125	R:R:F174	R:R:F234	3.22	No	Yes	0	8	9
126	R:R:F174	R:R:T239	3.89	No	No	0	8	4
127	R:R:F174	R:R:L242	6.09	No	No	0	8	6
128	R:R:F181	R:R:Y185	8.25	Yes	Yes	5	8	9
129	R:R:F181	R:R:I231	3.77	Yes	Yes	0	8	7
130	R:R:F181	R:R:F234	20.36	Yes	Yes	0	8	9
131	R:R:I231	R:R:V182	4.61	Yes	No	0	7	5
132	R:R:F183	R:R:F184	5.36	No	Yes	0	3	6
133	R:R:M188	R:R:Y185	4.79	No	Yes	0	9	9
134	R:R:L230	R:R:Y185	9.38	No	Yes	0	8	9
135	R:R:L189	R:R:L224	5.54	No	No	0	7	7
136	R:R:K190	R:R:M194	8.64	No	No	0	3	4
137	R:R:Q197	R:R:R200	11.68	No	No	0	5	4
138	R:R:H204	R:R:M208	3.94	No	No	0	4	2
139	R:R:A207	R:R:Y212	4	No	No	0	1	1
140	R:R:F221	R:R:L224	4.87	No	No	0	4	7
141	R:R:T226	R:R:W282	3.64	No	No	0	8	7
142	R:R:V229	R:R:W282	6.13	No	No	0	7	7
143	R:R:L230	R:R:Y279	3.52	No	Yes	0	8	9
144	R:R:C237	R:R:N271	12.6	No	No	0	7	9
145	R:R:F241	R:R:W238	6.01	Yes	Yes	1	6	8
146	R:R:G268	R:R:W238	9.85	No	Yes	0	7	8
147	R:R:N271	R:R:W238	3.39	No	Yes	0	9	8
148	L:L:?1	R:R:W238	10.13	Yes	Yes	1	0	8
149	R:R:P240	R:R:T239	5.25	No	No	0	9	4
150	R:R:L267	R:R:P240	4.93	No	No	0	7	9
151	R:R:F241	R:R:L260	4.87	Yes	Yes	0	6	4
152	L:L:?1	R:R:F241	6.19	Yes	Yes	1	0	6
153	R:R:L256	R:R:T244	5.9	No	Yes	0	5	4
154	R:R:L260	R:R:T244	7.37	Yes	Yes	0	4	4
155	R:R:L264	R:R:T244	4.42	No	Yes	0	4	4
156	R:R:G245	R:R:L260	3.42	No	Yes	0	6	4
157	R:R:L256	R:R:Q248	7.99	No	No	0	5	3
158	R:R:Q248	R:R:Y257	18.04	No	No	0	3	4
159	R:R:E253	R:R:H255	4.92	No	No	0	2	2
160	R:R:C254	R:R:Y257	8.06	No	No	0	4	4
161	R:R:H255	R:R:L258	3.86	No	No	0	2	1
162	R:R:L258	R:R:R262	4.86	No	No	0	1	3
163	R:R:V259	R:R:Y263	3.79	No	No	0	1	4
164	R:R:L264	R:R:V259	4.47	No	No	0	4	1
165	L:L:?1	R:R:E261	11.79	Yes	No	1	0	4
166	R:R:V269	R:R:W265	8.58	No	No	0	6	3
167	L:L:?1	R:R:W265	26.05	Yes	No	0	0	3
168	R:R:N271	R:R:N275	5.45	No	Yes	0	9	9
169	R:R:I278	R:R:Y279	3.63	No	Yes	0	8	9
170	R:R:R287	R:R:Y281	7.2	No	No	0	8	5
171	R:R:Q283	R:R:V286	5.73	No	No	0	8	9
172	R:R:R287	R:R:Y291	8.23	No	No	0	8	2
173	R:R:M293	R:R:Q289	8.16	No	Yes	0	5	7
174	R:R:A294	R:R:K298	4.82	No	No	0	6	4
175	R:R:T44	R:R:V29	3.17	No	No	0	7	8
176	R:R:C125	R:R:L98	3.17	No	No	0	6	7
177	R:R:C171	R:R:L167	3.17	No	No	0	4	5
178	R:R:T23	R:R:T52	3.14	No	No	0	5	6
179	R:R:I278	R:R:S233	3.1	No	No	0	8	7
180	R:R:R262	R:R:Y263	3.09	No	No	0	3	4
181	R:R:I33	R:R:V29	3.07	No	No	0	7	8
182	R:R:I231	R:R:V227	3.07	Yes	No	0	7	8
183	R:R:M117	R:R:V121	3.04	No	No	0	7	6
184	R:R:K152	R:R:V160	3.04	No	No	0	1	5
185	R:R:A28	R:R:Q289	3.03	No	Yes	0	7	7
186	R:R:L141	R:R:S79	3	No	No	0	6	4
187	R:R:L94	R:R:S133	3	No	No	0	5	8
188	R:R:L274	R:R:S233	3	No	No	0	5	7
189	R:R:L31	R:R:V27	2.98	No	No	0	5	5
190	R:R:L167	R:R:V249	2.98	No	No	0	5	4
191	R:R:L189	R:R:V227	2.98	No	No	0	7	8
192	R:R:L80	R:R:T76	2.95	No	No	0	5	2
193	R:R:I107	R:R:I191	2.94	No	No	0	8	6
194	R:R:I107	R:R:M188	2.92	No	No	0	8	9
195	R:R:D64	R:R:T73	2.89	No	No	0	4	5
196	R:R:I33	R:R:L41	2.85	No	No	0	7	9
197	R:R:Q74	R:R:T76	2.83	No	No	0	7	2
198	R:R:L290	R:R:M293	2.83	No	No	0	5	5
199	R:R:K284	R:R:L288	2.82	No	No	0	5	4
200	R:R:L32	R:R:L41	2.77	Yes	No	0	7	9
201	R:R:A122	R:R:F43	2.77	No	Yes	0	6	8
202	R:R:A57	R:R:F84	2.77	No	No	0	4	3
203	R:R:L62	R:R:L66	2.77	No	No	0	6	5
204	R:R:H195	R:R:I191	2.65	No	No	0	8	6
205	R:R:F161	R:R:V160	2.62	Yes	No	0	4	5
206	R:R:F146	R:R:T168	2.59	No	No	0	2	4
207	R:R:F175	R:R:M178	2.49	No	No	0	5	5
208	R:R:F234	R:R:M178	2.49	Yes	No	0	9	5
209	R:R:K284	R:R:R287	2.48	No	No	0	5	8
210	R:R:F138	R:R:L80	2.44	No	No	0	4	5
211	R:R:I58	R:R:W265	2.35	No	No	0	7	3
212	L:L:?1	R:R:G173	2.17	Yes	No	0	0	6
213	R:R:G210	R:R:G211	2.11	No	No	0	1	3
214	R:R:G153	R:R:P72	2.03	No	No	0	3	3
215	R:R:A122	R:R:G119	1.95	No	No	0	6	1
216	R:R:A122	R:R:G123	1.95	No	No	0	6	1
217	R:R:A127	R:R:G128	1.95	No	No	0	3	3
218	R:R:A235	R:R:G232	1.95	No	No	0	6	5
219	R:R:A26	R:R:A48	1.79	No	No	0	7	9
220	R:R:A192	R:R:A223	1.79	No	No	0	8	8
221	R:R:P69	R:R:S68	1.78	No	No	0	5	4
222	R:R:P276	R:R:V25	1.77	Yes	No	0	9	9
223	R:R:G232	R:R:I231	1.76	No	Yes	0	5	7
224	R:R:A15	R:R:S59	1.71	No	No	0	6	7
225	R:R:A50	R:R:S92	1.71	No	No	0	8	9
226	R:R:G142	R:R:L141	1.71	No	No	0	5	6
227	R:R:C171	R:R:V172	1.71	No	No	0	4	4
228	R:R:C186	R:R:V182	1.71	No	No	0	3	5
229	R:R:C251	R:R:V247	1.71	No	No	0	4	4
230	R:R:G296	R:R:L295	1.71	No	No	0	4	3
231	R:R:A48	R:R:V25	1.7	No	No	0	9	9
232	R:R:A280	R:R:V286	1.7	No	No	0	8	9
233	R:R:A280	R:R:T44	1.68	No	No	0	8	7
234	R:R:A150	R:R:T149	1.68	No	No	0	2	1
235	R:R:C42	R:R:I126	1.64	No	No	0	4	7
236	R:R:T226	R:R:V227	1.59	No	No	0	8	8
237	R:R:C237	R:R:L236	1.59	No	No	0	7	4
238	R:R:A12	R:R:L62	1.58	No	No	0	4	6
239	R:R:P110	R:R:Q109	1.58	No	No	0	8	5
240	R:R:A223	R:R:L189	1.58	No	No	0	8	7
241	R:R:I10	R:R:S6	1.55	No	No	0	4	2
242	R:R:I10	R:R:V9	1.54	No	No	0	4	5
243	R:R:I136	R:R:V132	1.54	No	No	0	6	3
244	R:R:M194	R:R:S193	1.53	No	No	0	4	6
245	R:R:I19	R:R:T23	1.52	No	No	0	6	5
246	R:R:I243	R:R:T244	1.52	No	Yes	0	5	4
247	R:R:C251	R:R:E253	1.52	No	No	0	4	2
248	R:R:A207	R:R:E203	1.51	No	No	0	1	3
249	R:R:L53	R:R:V49	1.49	No	No	0	8	6
250	R:R:L24	R:R:T23	1.47	No	No	0	8	5
251	R:R:D102	R:R:S40	1.47	No	No	0	9	8
252	R:R:I116	R:R:K115	1.45	No	No	0	5	4
253	R:R:G211	R:R:Y212	1.45	No	No	0	3	1
254	R:R:F175	R:R:P176	1.44	No	No	0	5	5
255	R:R:I278	R:R:L277	1.43	No	No	0	8	6
256	R:R:L180	R:R:M97	1.41	No	No	0	5	7
257	R:R:D187	R:R:K190	1.38	No	No	0	5	3
258	R:R:L105	R:R:Q109	1.33	No	No	0	5	5
259	R:R:R200	R:R:S196	1.32	No	No	0	4	5
260	R:R:H195	R:R:Q198	1.24	No	No	0	8	5
261	R:R:W282	R:R:Y281	0.96	No	No	0	7	5
262	L:L:?1	R:R:S156	0.95	Yes	No	0	0	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L32	4.0475	4	3	7
2	R:R:F43	5.446	5	0	8
3	R:R:N46	7.62	4	4	9
4	R:R:D51	6.794	5	2	9
5	R:R:Y104	11.75	4	6	8
6	R:R:W130	5.112	5	4	9
7	R:R:P140	7.7325	4	1	5
8	R:R:F157	12.708	5	1	4
9	R:R:F158	9.405	4	1	3
10	R:R:F161	7.15	4	1	4
11	R:R:F181	9.038	5	5	8
12	R:R:F184	8.305	4	0	6
13	R:R:Y185	7.26	5	5	9
14	R:R:I231	3.3025	4	0	7
15	R:R:F234	7.8275	4	0	9
16	R:R:W238	7.345	4	1	8
17	R:R:F241	5.5775	4	1	6
18	R:R:T244	4.8025	4	0	4
19	R:R:L260	5.7425	4	0	4
20	R:R:N275	5.8825	4	0	9
21	R:R:P276	4.565	4	2	9
22	R:R:Y279	3.87167	6	0	9
23	R:R:Q289	5.4575	4	0	7
24	L:L:?1	8.46692	13	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:R262	R:R:Y263	19.1407	3.09	No	No	0	3	4
2	R:R:V259	R:R:Y263	20.6654	3.79	No	No	0	1	4
3	R:R:L264	R:R:V259	22.1793	4.47	No	No	0	4	1
4	R:R:L264	R:R:T244	23.6822	4.42	No	Yes	0	4	4
5	R:R:L260	R:R:T244	44.9194	7.37	Yes	Yes	0	4	4
6	R:R:F241	R:R:L260	43.4437	4.87	Yes	Yes	0	6	4
7	L:L:?1	R:R:W265	13.276	26.05	Yes	No	0	0	3
8	R:R:F241	R:R:W238	39.7789	6.01	Yes	Yes	1	6	8
9	R:R:N271	R:R:W238	98.056	3.39	No	Yes	0	9	8
10	R:R:N271	R:R:N275	100	5.45	No	Yes	0	9	9
11	R:R:D51	R:R:N275	57.0627	4.04	Yes	Yes	0	9	9
12	R:R:D51	R:R:S272	18.9447	8.83	Yes	No	0	9	9
13	R:R:I54	R:R:S272	13.2978	9.29	No	No	0	8	9
14	R:R:D51	R:R:P276	37.7641	3.22	Yes	Yes	2	9	9
15	R:R:A280	R:R:V25	30.5162	3.39	No	No	0	8	9
16	R:R:P276	R:R:V25	34.976	1.77	Yes	No	0	9	9
17	R:R:A280	R:R:T44	25.9584	1.68	No	No	0	8	7
18	R:R:T44	R:R:V29	24.4173	3.17	No	No	0	7	8
19	R:R:I33	R:R:V29	19.7288	3.07	No	No	0	7	8
20	R:R:I33	R:R:L41	18.1442	2.85	No	No	0	7	9
21	R:R:L32	R:R:L41	16.5487	2.77	Yes	No	0	7	9
22	R:R:L32	R:R:Q289	10.0577	5.32	Yes	Yes	0	7	7
23	R:R:L47	R:R:N275	44.3095	9.61	No	Yes	0	9	9
24	R:R:L47	R:R:Y279	45.9431	3.52	No	Yes	0	9	9
25	R:R:I99	R:R:Y279	33.8543	3.63	No	Yes	0	9	9
26	R:R:F43	R:R:I99	31.8504	3.77	Yes	No	0	8	9
27	R:R:D102	R:R:F43	16.1947	8.36	No	Yes	0	9	8
28	R:R:D102	R:R:Y113	11.6206	8.05	No	No	0	9	9
29	R:R:N275	R:R:V96	83.5929	4.43	Yes	No	0	9	9
30	R:R:V96	R:R:Y279	41.7937	3.79	No	Yes	0	9	9
31	R:R:L47	R:R:T95	21.3189	5.9	No	No	0	9	8
32	R:R:N46	R:R:T95	19.8486	10.24	Yes	No	0	9	8
33	L:L:?1	R:R:T86	10.7656	6.56	Yes	No	0	0	5
34	R:R:W130	R:R:Y134	11.1468	5.79	Yes	No	0	9	4
35	R:R:C78	R:R:M82	11.6206	3.24	No	No	0	9	5
36	R:R:F157	R:R:M82	12.4102	6.22	Yes	No	1	4	5
37	R:R:F157	R:R:F161	25.2069	9.65	Yes	Yes	1	4	4
38	R:R:F161	R:R:V160	18.0843	2.62	Yes	No	0	4	5
39	R:R:S79	R:R:V160	13.2814	6.46	No	No	0	4	5
40	R:R:L141	R:R:S79	11.6587	3	No	No	0	6	4
41	R:R:A91	R:R:W130	10.7765	3.89	No	Yes	0	7	9
42	R:R:F234	R:R:V96	57.2261	5.24	Yes	No	0	9	9
43	R:R:F181	R:R:F234	47.0322	20.36	Yes	Yes	0	8	9
44	R:R:F181	R:R:T100	13.1072	9.08	Yes	No	5	8	8
45	R:R:F184	R:R:T100	15.3289	3.89	Yes	No	0	6	8
46	R:R:R103	R:R:Y279	28.6702	5.14	No	Yes	0	9	9
47	R:R:R103	R:R:Y185	27.2108	5.14	No	Yes	0	9	9
48	R:R:L230	R:R:Y279	28.6702	3.52	No	Yes	0	8	9
49	R:R:L230	R:R:Y185	27.2108	9.38	No	Yes	0	8	9
50	R:R:F181	R:R:Y185	21.3951	8.25	Yes	Yes	5	8	9
51	R:R:M188	R:R:Y185	47.7619	4.79	No	Yes	0	9	9
52	R:R:M188	R:R:Y104	26.3886	3.59	No	Yes	0	9	8
53	R:R:D187	R:R:Y104	21.406	10.34	No	Yes	6	5	8
54	R:R:F165	R:R:L169	10.1231	6.09	No	No	0	6	6
55	L:L:?1	R:R:L169	11.6097	4.4	Yes	No	0	0	6
56	R:R:L256	R:R:T244	20.6654	5.9	No	Yes	0	5	4
57	R:R:L256	R:R:Q248	19.1407	7.99	No	No	0	5	3
58	R:R:Q248	R:R:Y257	17.6051	18.04	No	No	0	3	4
59	R:R:P163	R:R:Y257	14.5012	9.74	No	No	0	3	4
60	R:R:F181	R:R:I231	32.689	3.77	Yes	Yes	0	8	7
61	R:R:I231	R:R:V227	24.4663	3.07	Yes	No	0	7	8
62	R:R:D187	R:R:K190	16.0858	1.38	No	No	0	5	3
63	R:R:K190	R:R:M194	10.733	8.64	No	No	0	3	4
64	R:R:T226	R:R:V227	14.2398	1.59	No	No	0	8	8
65	R:R:T226	R:R:W282	12.4973	3.64	No	No	0	8	7
66	R:R:I107	R:R:M188	17.6813	2.92	No	No	0	8	9
67	R:R:I107	R:R:I191	13.276	2.94	No	No	0	8	6
68	L:L:?1	R:R:W238	57.0301	10.13	Yes	Yes	1	0	8
69	R:R:N46	R:R:W130	17.5833	9.04	Yes	Yes	4	9	9
70	L:L:?1	R:R:F157	35.1721	20.12	Yes	Yes	1	0	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L61	4.4	1	Yes	No	0	5	0	1
R:R:F157	R:R:M82	6.22	1	Yes	No	4	5	1	2
R:R:F161	R:R:M82	6.22	1	Yes	No	4	5	2	2
L:L:?1	R:R:V85	5.68	1	Yes	No	0	7	0	1
R:R:G137	R:R:T86	3.64	0	No	No	7	5	2	1
L:L:?1	R:R:T86	6.56	1	Yes	No	0	5	0	1
L:L:?1	R:R:A89	5	1	Yes	No	0	6	0	1
L:L:?1	R:R:V93	6.63	1	Yes	No	0	7	0	1
R:R:A159	R:R:S156	3.42	0	No	No	4	4	2	1
R:R:F157	R:R:F158	18.22	1	Yes	Yes	4	3	1	2
R:R:F157	R:R:F161	9.65	1	Yes	Yes	4	4	1	2
R:R:E261	R:R:F157	9.33	1	No	Yes	4	4	1	1
L:L:?1	R:R:F157	20.12	1	Yes	Yes	0	4	0	1
R:R:F158	R:R:V166	3.93	1	Yes	No	3	6	2	2
R:R:F158	R:R:L260	7.31	1	Yes	Yes	3	4	2	2
R:R:E261	R:R:F158	8.16	1	No	Yes	4	3	1	2
R:R:F165	R:R:L169	6.09	1	No	No	6	6	2	1
R:R:F241	R:R:V166	5.24	1	Yes	No	6	6	1	2
L:L:?1	R:R:L169	4.4	1	Yes	No	0	6	0	1
R:R:F241	R:R:W238	6.01	1	Yes	Yes	6	8	1	1
R:R:G268	R:R:W238	9.85	0	No	Yes	7	8	2	1
R:R:N271	R:R:W238	3.39	0	No	Yes	9	8	2	1
L:L:?1	R:R:W238	10.13	1	Yes	Yes	0	8	0	1
R:R:F241	R:R:L260	4.87	1	Yes	Yes	6	4	1	2
L:L:?1	R:R:F241	6.19	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:E261	11.79	1	Yes	No	0	4	0	1
R:R:V269	R:R:W265	8.58	0	No	No	6	3	2	1
L:L:?1	R:R:W265	26.05	1	Yes	No	0	3	0	1
R:R:I58	R:R:W265	2.35	0	No	No	7	3	2	1
L:L:?1	R:R:G173	2.17	1	Yes	No	0	6	0	1
L:L:?1	R:R:S156	0.95	1	Yes	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7WCN_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.22
Number of Linked Nodes	252
Number of Links	262
Number of Hubs	24
Number of Links mediated by Hubs	95
Number of Communities	6
Number of Nodes involved in Communities	26
Number of Links involved in Communities	30

Path Summary
Number Of Nodes in MetaPath	71
Number Of Links MetaPath	70
Number of Shortest Paths	40697
Length Of Smallest Path	3
Average Path Length	12.5384
Length of Longest Path	27
Minimum Path Strength	1.455
Average Path Strength	5.93126
Maximum Path Strength	23.085
Minimum Path Correlation	0.7
Average Path Correlation	0.94901
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	6.66667
Average % Of Corr. Nodes	67.5684
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.5178
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • metabolic process • regulation of metabolic process • establishment of protein localization • nitrogen compound transport • transport • hormone secretion • protein localization to extracellular region • peptide secretion • localization • secretion by cell • amide transport • signal release • regulation of biological quality • intracellular protein localization • secretion • regulation of hormone levels • establishment of protein localization to extracellular region • cell-cell signaling • export from cell • protein secretion • establishment of localization • peptide transport • protein transport • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • protein-containing complex • receptor complex • cell periphery • cellular anatomical structure • plasma membrane • membrane • intracellular anatomical structure • cytoplasm • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of multicellular organismal process • positive regulation of cellular process • regulation of localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • regulation of secretion by cell • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • regulation of protein secretion • regulation of secretion • regulation of insulin secretion • regulation of cell communication • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • endomembrane system • trans-Golgi network
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	8WL
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	8WL
Name	N-(2-fluoranyl-4-methylsulfonyl-phenyl)-5-nitro-6-[4-(3-propan-2-yl-1,2,4-oxadiazol-5-yl)piperidin-1-yl]pyrimidin-4-amine
Synonyms	AR231453
Identifier
Formula	C21 H24 F N7 O5 S
Molecular Weight	505.523
SMILES
PubChem	24939268
Formal Charge	0
Total Atoms	59
Total Chiral Atoms	0
Total Bonds	62
Total Aromatic Bonds	17


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDV5
Sequence	>7WCN_nogp_Chain_R F S F G V I L A V L A S L I I A T N T L V A V A V L L L I H K N D G V S L C F T L N L A V A D T L I G V A I S G L L T D Q L S S P S R P T Q K T L C S L R M A F V T S S A A A S V L T V M L I T F D R Y L A I K Q P F R Y L K I M S G F V A G A C I A G L W L V S Y L I G F L P L G I P M F Q Q T A Y K G Q C S F F A V F H P H F V L T L S C V G F F P A M L L F V F F Y C D M L K I A S M H S Q Q I R K M E H A G A M A G G Y D F K A L R T V S V L I G S F A L C W T P F L I T G I V Q V A C Q E C H L Y L V L E R Y L W L L G V G N S L L N P L I Y A Y W Q K E V R L Q L Y H M A L G V K K V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7WCM	A	Lipid	GPR119	GPR119	Homo sapiens	MBX-2982	-	Gs/β1/γ2	2.33	2022-12-21	doi.org/10.1038/s41467-022-34696-6
	7WCM (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	MBX-2982	-		2.33	2022-12-21	doi.org/10.1038/s41467-022-34696-6
	7WCN	A	Lipid	GPR119	GPR119	Homo sapiens	AR231453	-	Gs/β1/γ2	2.87	2022-12-21	doi.org/10.1038/s41467-022-34696-6
	7WCN (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	AR231453	-		2.87	2022-12-21	doi.org/10.1038/s41467-022-34696-6
	7XZ5	A	Lipid	GPR119	GPR119	Homo sapiens	Lysophosphatidylcholine	-	Gs/β1/γ2	3.1	2022-08-24	doi.org/10.1038/s41594-022-00816-5
	7XZ5 (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	Lysophosphatidylcholine	-		3.1	2022-08-24	doi.org/10.1038/s41594-022-00816-5
	7XZ6	A	Lipid	GPR119	GPR119	Homo sapiens	APD668	-	Gs/β1/γ2	2.8	2022-08-24	doi.org/10.1038/s41594-022-00816-5
	7XZ6 (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	APD668	-		2.8	2022-08-24	doi.org/10.1038/s41594-022-00816-5
	8VHF	A	Lipid	GPR119	GPR119	Homo sapiens	MBX-2982	-	Gs/β1/γ2	3.51	2024-10-30	doi.org/10.1016/j.str.2024.10.004
	8VHF (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	MBX-2982	-		3.51	2024-10-30	doi.org/10.1016/j.str.2024.10.004
	8ZR5	A	Lipid	GPR119	GPR119	Homo sapiens	Firuglipel	-	Gs/β1/γ2	3.31	2024-06-19	To be published
	8ZR5 (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	Firuglipel	-		3.31	2024-06-19	To be published
	8ZRK	A	Lipid	GPR119	GPR119	Homo sapiens	GSK-1292263	-	Gs/β1/γ2	2.82	2024-06-19	To be published
	8ZRK (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	GSK-1292263	-		2.82	2024-06-19	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7WCN_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.