Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:?1 10.00381310
2R:R:F7 7.908515
3R:R:L11 4.82416
4R:R:N22 8.04409
5R:R:N46 7.48429
6R:R:D51 8.7325409
7R:R:Q65 5.965404
8R:R:R81 5.704506
9R:R:K108 5.3125446
10R:R:Q109 4.1225405
11R:R:Y113 7.494509
12R:R:W130 3.965629
13R:R:F146 6.6275402
14R:R:Y151 7.0575404
15R:R:F157 8.125414
16R:R:F158 8.51286713
17R:R:F161 8.915414
18R:R:F165 8.6225416
19R:R:F174 4.212508
20R:R:M178 2.47405
21R:R:F181 12.2425438
22R:R:F184 9.1175406
23R:R:Y185 11.6439
24R:R:F234 7.28409
25R:R:W238 8.204518
26R:R:R262 6.9825403
27R:R:W265 9.06333613
28R:R:N275 7.6175429
29R:R:Y279 4.535629
30R:R:L290 2.825405
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:?1 R:R:R262 11.6019.13YesYes003
2L:L:?1 R:R:Q65 22.94697.28YesYes004
3L:L:?1 R:R:W265 40.200931.92YesYes103
4R:R:V269 R:R:W265 35.82363.68NoYes063
5R:R:L14 R:R:V269 35.75194.47NoNo056
6R:R:I18 R:R:L14 35.68017.14NoNo085
7R:R:I18 R:R:N22 31.51014.25NoYes089
8R:R:G55 R:R:I18 17.67661.76NoNo088
9R:R:G55 R:R:I19 15.10133.53NoNo086
10R:R:N22 R:R:P276 38.319211.4YesNo099
11L:L:?1 R:R:W238 95.614714.79YesYes108
12R:R:S237 R:R:W238 99.6976.18NoYes078
13R:R:N271 R:R:S237 99.84857.45NoNo097
14R:R:N271 R:R:N275 10013.62NoYes099
15R:R:D51 R:R:N275 38.35918.08YesYes099
16R:R:P276 R:R:V25 32.88953.53NoNo099
17R:R:A280 R:R:V25 27.50765.09NoNo089
18R:R:L47 R:R:N275 43.24674.12NoYes299
19R:R:L47 R:R:T95 58.73077.37NoNo298
20R:R:N46 R:R:T95 40.830810.24YesNo298
21R:R:I126 R:R:N46 26.39939.91NoYes079
22R:R:C42 R:R:I126 24.77281.64NoNo047
23R:R:C42 R:R:I33 23.15421.64NoNo047
24R:R:I33 R:R:V29 10.07813.07NoNo078
25R:R:A280 R:R:V286 25.73751.7NoNo089
26R:R:L290 R:R:V286 22.18152.98YesNo059
27R:R:L290 R:R:M293 13.24352.83YesNo055
28R:R:I33 R:R:L41 13.29935.71NoNo079
29R:R:N275 R:R:Y279 80.964.65YesYes299
30R:R:V96 R:R:Y279 88.61436.31NoYes099
31R:R:F234 R:R:V96 87.35455.24YesNo099
32R:R:F181 R:R:F234 76.702313.93YesYes089
33R:R:F181 R:R:Y185 63.219619.6YesYes389
34R:R:M188 R:R:Y185 57.20788.38NoYes099
35R:R:I107 R:R:M188 55.58925.83NoNo089
36R:R:I107 R:R:I191 54.08232.94NoNo086
37R:R:I191 R:R:K108 50.78142.91NoYes066
38R:R:K108 R:R:Q109 38.74184.07YesYes065
39R:R:L105 R:R:Q109 33.3362.66NoYes055
40R:R:L105 R:R:Y113 31.50223.52NoYes059
41R:R:D102 R:R:Y113 22.093811.49NoYes099
42R:R:D102 R:R:F43 18.21888.36NoNo098
43R:R:L129 R:R:T95 16.35315.9NoNo268
44R:R:N46 R:R:W130 16.19365.65YesYes299
45R:R:L129 R:R:W130 14.59893.42NoYes269
46R:R:D51 R:R:S272 11.138610.31YesNo099
47R:R:D64 R:R:Q65 21.50373.92NoYes044
48R:R:D64 R:R:R81 19.12775.96NoYes046
49L:L:?1 R:R:F157 56.2439.99YesYes104
50R:R:F157 R:R:F161 25.21936.43YesYes144
51R:R:F161 R:R:V160 20.602810.49YesNo045
52L:L:?1 R:R:L94 10.19774.73YesNo005
53R:R:A91 R:R:W130 11.66483.89NoYes079
54L:L:?1 R:R:V93 13.27545.09YesNo007
55R:R:F174 R:R:V93 12.42233.93YesNo087
56R:R:F174 R:R:W238 26.00065.01YesYes088
57R:R:K108 R:R:Y104 10.23765.97YesNo468
58R:R:F157 R:R:F165 14.22425.36YesYes146
59R:R:F157 R:R:F158 22.803410.72YesYes143
60R:R:F158 R:R:P163 20.46727.22YesNo033
61R:R:H162 R:R:P163 15.37239.15NoNo053
62L:L:?1 R:R:F241 30.3544.99YesNo106
63R:R:F158 R:R:F241 19.25534.29YesNo136
64L:L:?1 R:R:E261 20.634714.49YesNo104
65R:R:E261 R:R:F158 19.454615.16NoYes143
66R:R:F158 R:R:Y257 25.6027.22YesNo034
67R:R:F174 R:R:L242 17.30986.09YesNo086
68R:R:L242 R:R:S170 14.46344.5NoNo066
69R:R:I246 R:R:S170 11.6014.64NoNo056
70R:R:F234 R:R:M178 10.27753.73YesYes095
71R:R:F181 R:R:I231 14.283.77YesNo087
72R:R:I231 R:R:V227 10.27753.07NoNo078
73R:R:I278 R:R:Y279 10.27754.84NoYes089
74R:R:Q248 R:R:Y257 20.57893.38NoNo034
75R:R:C254 R:R:Q248 15.37234.58NoNo043
76R:R:C251 R:R:C254 10.26157.28NoNo044
77R:R:D51 R:R:N22 26.79812.12YesYes099
78R:R:L47 R:R:Y279 17.01484.69NoYes299
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:Q65 7.28 1 Yes Yes 0 4 0 1
L:L:?1 R:R:A89 4.31 1 Yes No 0 6 0 1
L:L:?1 R:R:V93 5.09 1 Yes No 0 7 0 1
L:L:?1 R:R:L94 4.73 1 Yes No 0 5 0 1
L:L:?1 R:R:S156 14.37 1 Yes No 0 4 0 1
L:L:?1 R:R:F157 9.99 1 Yes Yes 0 4 0 1
L:L:?1 R:R:L169 6.62 1 Yes No 0 6 0 1
L:L:?1 R:R:W238 14.79 1 Yes Yes 0 8 0 1
L:L:?1 R:R:F241 4.99 1 Yes No 0 6 0 1
L:L:?1 R:R:E261 14.49 1 Yes No 0 4 0 1
L:L:?1 R:R:R262 9.13 1 Yes Yes 0 3 0 1
L:L:?1 R:R:W265 31.92 1 Yes Yes 0 3 0 1
R:R:R262 R:R:S3 3.95 0 Yes No 3 6 1 2
R:R:F7 R:R:L11 8.53 1 Yes Yes 5 6 2 2
R:R:F7 R:R:Q65 9.37 1 Yes Yes 5 4 2 1
R:R:F7 R:R:R262 11.76 1 Yes Yes 5 3 2 1
R:R:F7 R:R:W265 5.01 1 Yes Yes 5 3 2 1
R:R:F7 R:R:L266 4.87 1 Yes No 5 5 2 2
R:R:G8 R:R:L11 3.42 0 No Yes 4 6 2 2
R:R:G8 R:R:Q65 3.29 0 No Yes 4 4 2 1
R:R:L11 R:R:W265 4.56 1 Yes Yes 6 3 2 1
R:R:I58 R:R:W265 3.52 0 No Yes 7 3 2 1
R:R:D64 R:R:Q65 3.92 0 No Yes 4 4 2 1
R:R:A89 R:R:W238 5.19 1 No Yes 6 8 1 1
R:R:F174 R:R:V93 3.93 0 Yes No 8 7 2 1
R:R:A159 R:R:S156 3.42 0 No No 4 4 2 1
R:R:E261 R:R:S156 10.06 1 No No 4 4 1 1
R:R:F157 R:R:F158 10.72 1 Yes Yes 4 3 1 2
R:R:F157 R:R:F161 6.43 1 Yes Yes 4 4 1 2
R:R:F157 R:R:F165 5.36 1 Yes Yes 4 6 1 2
R:R:F158 R:R:F241 4.29 1 Yes No 3 6 2 1
R:R:F158 R:R:L260 9.74 1 Yes No 3 4 2 2
R:R:E261 R:R:F158 15.16 1 No Yes 4 3 1 2
R:R:F161 R:R:F165 4.29 1 Yes Yes 4 6 2 2
R:R:F174 R:R:W238 5.01 0 Yes Yes 8 8 2 1
R:R:S237 R:R:W238 6.18 0 No Yes 7 8 2 1
R:R:G268 R:R:W238 9.85 0 No Yes 7 8 2 1
R:R:F241 R:R:L260 9.74 1 No No 6 4 1 2
R:R:L266 R:R:W265 5.69 1 No Yes 5 3 2 1
R:R:V269 R:R:W265 3.68 0 No Yes 6 3 2 1
R:R:R262 R:R:Y263 3.09 0 Yes No 3 4 1 2
R:R:L94 R:R:V132 2.98 0 No No 5 3 1 2
L:L:?1 R:R:G173 2.34 1 Yes No 0 6 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 7XZ5_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.24
Number of Linked Nodes 263
Number of Links 268
Number of Hubs 30
Number of Links mediated by Hubs 119
Number of Communities 4
Number of Nodes involved in Communities 29
Number of Links involved in Communities 39
Path Summary
Number Of Nodes in MetaPath 79
Number Of Links MetaPath 78
Number of Shortest Paths 33622
Length Of Smallest Path 3
Average Path Length 12.6517
Length of Longest Path 31
Minimum Path Strength 1.465
Average Path Strength 7.16964
Maximum Path Strength 23.355
Minimum Path Correlation 0.7
Average Path Correlation 0.942451
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 4
Average % Of Corr. Nodes 62.3853
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 41.775
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • enzyme regulator activity   • molecular function activator activity   • phosphorus-oxygen lyase activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • adenylate cyclase activator activity   • adenylate cyclase activity   • cation binding   • metal ion binding   • developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development
Gene OntologyBiological Process• developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • cellular response to stimulus   • cellular response to nitrogen compound   • response to stimulus   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to chemical   • cellular process   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • biological regulation   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • regulation of biological process   • regulation of cellular process   • signaling   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of multicellular organismal process   • regulation of metabolic process   • positive regulation of cellular process   • protein localization   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • localization   • cellular macromolecule localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • protein transport   • regulation of cellular localization   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • intracellular anatomical structure   • cytoplasm   • cytosol   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • trans-Golgi network   • organelle membrane   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation   • cation binding   • ion binding   • phosphatidylcholine binding   • phospholipid binding   • lipid binding   • quaternary ammonium group binding   • small molecule binding   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • tetrapyrrole binding   • heme binding   • electron transfer activity   • transition metal ion binding   • iron ion binding   • metal ion binding   • metabolic process   • regulation of metabolic process   • protein localization   • establishment of protein localization   • cellular localization   • nitrogen compound transport   • transport   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • localization   • secretion by cell   • amide transport   • signal release   • cellular macromolecule localization   • regulation of biological quality   • secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • export from cell   • protein secretion   • establishment of localization   • peptide transport   • protein transport   • peptide hormone secretion   • macromolecule localization   • hormone transport   • insulin secretion   • electron transport chain   • generation of precursor metabolites and energy   • receptor complex   • periplasmic space
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeLSC
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeLSC
Name(4R,7R,18E)-4,7-dihydroxy-N,N,N-trimethyl-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide
Synonyms
Identifier
FormulaC26 H53 N O7 P
Molecular Weight522.675
SMILES
PubChem5313986
Formal Charge1
Total Atoms88
Total Chiral Atoms1
Total Bonds87
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ8TDV5
Sequence
>7XZ5_nogp_Chain_R
MESSFSFGV ILAVLASLI IATNTLVAV AVLLLIHKN DGVSLCFTL 
NLAVADTLI GVAISGLLT DQLSSPSRP TQKTLCSLR MAFVTSSAA 
ASVLTVMLI TFDRYLAIK QPFRYLKIM SGFVAGACI AGLWLVSYL 
IGFLPLGIP MFQQTAYKG QCSFFAVFH PHFVLTLSC VGFFPAMLL 
FVFFYCDML KIASMHSQQ IRKMEHAGA MAGSDFKAL RTVSVLIGS 
FALSWTPFL ITGIVQVAC QECHLYLVL ERYLWLLGV GNSLLNPLI 
YAYWQKEVR LQLYHMALG VKKV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8VHFALipidGPR119GPR119Homo sapiensMBX-2982-Gs/β1/γ23.512024-10-30doi.org/10.1016/j.str.2024.10.004
8VHF (No Gprot) ALipidGPR119GPR119Homo sapiensMBX-2982-3.512024-10-30doi.org/10.1016/j.str.2024.10.004
8ZRKALipidGPR119GPR119Homo sapiensGSK-1292263-Gs/β1/γ22.822024-06-19To be published
8ZRK (No Gprot) ALipidGPR119GPR119Homo sapiensGSK-1292263-2.822024-06-19To be published
8ZR5ALipidGPR119GPR119Homo sapiensFiruglipel-Gs/β1/γ23.312024-06-19To be published
8ZR5 (No Gprot) ALipidGPR119GPR119Homo sapiensFiruglipel-3.312024-06-19To be published
7WCNALipidGPR119GPR119Homo sapiensAR231453-Gs/β1/γ22.872022-12-2110.1038/s41467-022-34696-6
7WCN (No Gprot) ALipidGPR119GPR119Homo sapiensAR231453-2.872022-12-2110.1038/s41467-022-34696-6
7WCMALipidGPR119GPR119Homo sapiensMBX-2982-Gs/β1/γ22.332022-12-2110.1038/s41467-022-34696-6
7WCM (No Gprot) ALipidGPR119GPR119Homo sapiensMBX-2982-2.332022-12-2110.1038/s41467-022-34696-6
7XZ6ALipidGPR119GPR119Homo sapiensAPD668-Gs/β1/γ22.82022-08-2410.1038/s41594-022-00816-5
7XZ6 (No Gprot) ALipidGPR119GPR119Homo sapiensAPD668-2.82022-08-2410.1038/s41594-022-00816-5
7XZ5ALipidGPR119GPR119Homo sapiensLysophosphatidylcholine-Gs/β1/γ23.12022-08-2410.1038/s41594-022-00816-5
7XZ5 (No Gprot) ALipidGPR119GPR119Homo sapiensLysophosphatidylcholine-3.12022-08-2410.1038/s41594-022-00816-5




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7XZ5_nogp.zip



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