psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F7	R:R:L11	10.96	Yes	No	0	5	6
2	R:R:F7	R:R:R262	21.38	Yes	No	0	5	3
3	L:L:?1	R:R:F7	4.15	Yes	Yes	0	0	5
4	R:R:G8	R:R:L66	3.42	No	Yes	0	4	5
5	R:R:L11	R:R:W265	4.56	No	Yes	0	6	3
6	R:R:A12	R:R:L62	3.15	No	No	0	4	6
7	R:R:A15	R:R:I58	3.25	No	No	0	6	7
8	R:R:A15	R:R:S59	3.42	No	No	0	6	7
9	R:R:I18	R:R:S272	3.1	No	No	0	8	9
10	R:R:I18	R:R:L273	5.71	No	No	0	8	5
11	R:R:G55	R:R:I19	3.53	No	No	0	8	6
12	R:R:D51	R:R:N22	13.46	Yes	Yes	2	9	9
13	R:R:N22	R:R:T52	4.39	Yes	No	0	9	6
14	R:R:N22	R:R:P276	8.15	Yes	No	2	9	9
15	R:R:A280	R:R:V25	5.09	No	Yes	0	8	9
16	R:R:M293	R:R:V27	4.56	No	No	0	5	5
17	R:R:I33	R:R:V29	3.07	No	No	0	7	8
18	R:R:L45	R:R:V29	5.96	No	No	0	6	8
19	R:R:L30	R:R:L45	8.3	No	No	0	3	6
20	R:R:L31	R:R:Q289	5.32	No	Yes	0	5	7
21	R:R:L32	R:R:Q289	5.32	Yes	Yes	0	7	7
22	R:R:I33	R:R:L41	5.71	No	No	0	7	9
23	R:R:K35	R:R:N36	4.2	No	No	0	6	9
24	R:R:A122	R:R:V39	3.39	No	No	0	6	5
25	R:R:F43	R:R:L98	7.31	Yes	No	0	8	7
26	R:R:D102	R:R:F43	8.36	No	Yes	0	9	8
27	R:R:F43	R:R:I126	5.02	Yes	No	0	8	7
28	R:R:N46	R:R:T95	8.77	No	No	0	9	8
29	R:R:I126	R:R:N46	11.33	No	No	0	7	9
30	R:R:N46	R:R:W130	7.91	No	Yes	0	9	9
31	R:R:D51	R:R:L47	4.07	Yes	Yes	2	9	9
32	R:R:L47	R:R:T95	7.37	Yes	No	0	9	8
33	R:R:L47	R:R:N275	5.49	Yes	Yes	2	9	9
34	R:R:L47	R:R:Y279	3.52	Yes	Yes	0	9	9
35	R:R:A50	R:R:S92	3.42	No	No	0	8	9
36	R:R:D51	R:R:S92	4.42	Yes	No	0	9	9
37	R:R:D51	R:R:S272	8.83	Yes	No	0	9	9
38	R:R:D51	R:R:N275	6.73	Yes	Yes	2	9	9
39	R:R:D51	R:R:P276	3.22	Yes	No	2	9	9
40	R:R:G55	R:R:I54	3.53	No	Yes	0	8	8
41	R:R:I54	R:R:S88	3.1	Yes	No	0	8	6
42	R:R:I54	R:R:S92	4.64	Yes	No	0	8	9
43	R:R:I54	R:R:S272	9.29	Yes	No	0	8	9
44	R:R:A57	R:R:F84	5.55	No	No	0	4	3
45	R:R:A57	R:R:V85	3.39	No	No	0	4	7
46	R:R:I58	R:R:V85	3.07	No	No	0	7	7
47	R:R:I58	R:R:W265	4.7	No	Yes	0	7	3
48	R:R:L61	R:R:R81	4.86	No	No	0	5	6
49	R:R:D64	R:R:T63	7.23	No	No	0	4	5
50	R:R:D64	R:R:S68	7.36	No	No	0	4	4
51	R:R:D64	R:R:R81	4.76	No	No	0	4	6
52	R:R:R71	R:R:S68	3.95	No	No	0	6	4
53	R:R:L77	R:R:T73	4.42	No	No	0	4	5
54	R:R:C155	R:R:T73	8.45	No	No	0	9	5
55	R:R:K152	R:R:K75	21.55	No	No	0	1	3
56	R:R:L77	R:R:R81	10.93	No	No	0	4	6
57	R:R:C78	R:R:M82	3.24	No	No	0	9	5
58	R:R:C155	R:R:C78	7.28	No	No	0	9	9
59	L:L:?1	R:R:M82	3.21	Yes	No	0	0	5
60	R:R:A83	R:R:F138	4.16	No	No	0	6	4
61	R:R:F84	R:R:S88	3.96	No	No	0	3	6
62	L:L:?1	R:R:T86	6.7	Yes	No	0	0	5
63	R:R:S87	R:R:Y134	3.82	No	No	0	5	4
64	R:R:G137	R:R:S87	3.71	No	No	0	7	5
65	R:R:A91	R:R:W130	3.89	No	Yes	0	7	9
66	R:R:A91	R:R:S133	3.42	No	No	0	7	8
67	L:L:?1	R:R:V93	9.31	Yes	No	0	0	7
68	R:R:L129	R:R:L94	5.54	No	No	0	6	5
69	R:R:L129	R:R:T95	5.9	No	No	0	6	8
70	R:R:F234	R:R:V96	5.24	Yes	No	0	9	9
71	R:R:N275	R:R:V96	4.43	Yes	No	0	9	9
72	R:R:V96	R:R:Y279	3.79	No	Yes	0	9	9
73	R:R:A177	R:R:M97	4.83	No	No	0	8	7
74	R:R:F234	R:R:M97	4.98	Yes	No	0	9	7
75	R:R:C125	R:R:L98	3.17	No	No	0	6	7
76	R:R:F181	R:R:T100	9.08	No	No	3	8	8
77	R:R:F184	R:R:T100	3.89	Yes	No	0	6	8
78	R:R:T100	R:R:Y185	7.49	No	Yes	3	8	9
79	R:R:F101	R:R:L105	13.4	No	No	0	5	5
80	R:R:F101	R:R:F184	6.43	No	Yes	0	5	6
81	R:R:D102	R:R:Y113	9.2	No	No	0	9	9
82	R:R:R103	R:R:Y185	5.14	No	Yes	0	9	9
83	R:R:R103	R:R:Y279	4.12	No	Yes	0	9	9
84	R:R:K108	R:R:Y104	11.94	No	Yes	4	6	8
85	R:R:F184	R:R:Y104	21.66	Yes	Yes	0	6	8
86	R:R:D187	R:R:Y104	10.34	No	Yes	4	5	8
87	R:R:M188	R:R:Y104	4.79	No	Yes	0	9	8
88	R:R:A106	R:R:Y113	9.34	No	No	0	9	9
89	R:R:K108	R:R:Q109	4.07	No	No	0	6	5
90	R:R:D187	R:R:K108	4.15	No	No	4	5	6
91	R:R:Q109	R:R:R112	11.68	No	No	0	5	5
92	R:R:M117	R:R:Y113	10.78	No	No	0	7	9
93	R:R:G119	R:R:S118	3.71	No	No	0	1	8
94	R:R:W130	R:R:Y134	6.75	Yes	No	0	9	4
95	R:R:I136	R:R:V132	3.07	No	No	0	6	3
96	R:R:S133	R:R:Y134	3.82	No	No	0	8	4
97	R:R:L139	R:R:P140	3.28	No	No	0	4	5
98	R:R:I143	R:R:L139	5.71	No	No	0	4	4
99	R:R:F146	R:R:P140	8.67	Yes	No	1	2	5
100	R:R:F165	R:R:P140	7.22	No	No	1	6	5
101	R:R:F161	R:R:L141	3.65	No	No	0	4	6
102	R:R:I143	R:R:P144	3.39	No	No	0	4	2
103	R:R:F146	R:R:M145	4.98	Yes	No	0	2	3
104	R:R:H164	R:R:M145	3.94	No	No	0	2	3
105	R:R:F146	R:R:F165	5.36	Yes	No	1	2	6
106	R:R:F146	R:R:T168	3.89	Yes	No	0	2	4
107	R:R:G153	R:R:Y151	8.69	No	No	0	3	4
108	R:R:E261	R:R:S156	7.19	Yes	No	0	4	4
109	R:R:F157	R:R:F158	13.93	Yes	Yes	1	4	3
110	R:R:F157	R:R:F161	9.65	Yes	No	0	4	4
111	R:R:E261	R:R:F157	5.83	Yes	Yes	1	4	4
112	L:L:?1	R:R:F157	24.9	Yes	Yes	1	0	4
113	R:R:F158	R:R:P163	4.33	Yes	No	0	3	3
114	R:R:E261	R:R:F158	7	Yes	Yes	1	4	3
115	R:R:H162	R:R:P163	10.68	No	No	0	5	3
116	R:R:H162	R:R:H164	10.75	No	No	0	5	2
117	R:R:I246	R:R:L167	4.28	No	No	0	5	5
118	R:R:L167	R:R:V249	4.47	No	No	0	5	4
119	R:R:C171	R:R:T168	3.38	No	No	0	4	4
120	L:L:?1	R:R:L169	11	Yes	No	0	0	6
121	R:R:F175	R:R:S170	7.93	No	No	0	5	6
122	R:R:L242	R:R:S170	7.51	No	No	0	6	6
123	R:R:I246	R:R:S170	4.64	No	No	0	5	6
124	R:R:C171	R:R:V172	3.42	No	No	0	4	4
125	L:L:?1	R:R:G173	3.89	Yes	No	0	0	6
126	R:R:F174	R:R:F175	4.29	No	No	0	8	5
127	R:R:F174	R:R:W238	4.01	No	Yes	1	8	8
128	L:L:?1	R:R:F174	5.53	Yes	No	1	0	8
129	R:R:F234	R:R:M178	4.98	Yes	No	0	9	5
130	R:R:F181	R:R:Y185	8.25	No	Yes	3	8	9
131	R:R:F181	R:R:F234	26.79	No	Yes	0	8	9
132	R:R:I231	R:R:V182	4.61	No	No	0	7	5
133	R:R:F183	R:R:F184	5.36	No	Yes	0	3	6
134	R:R:M188	R:R:Y185	7.18	No	Yes	0	9	9
135	R:R:V227	R:R:Y185	3.79	No	Yes	0	8	9
136	R:R:L230	R:R:Y185	10.55	No	Yes	0	8	9
137	R:R:H195	R:R:M194	6.57	No	No	0	8	4
138	R:R:R200	R:R:S196	5.27	No	No	0	4	5
139	R:R:E203	R:R:I199	4.1	No	No	0	3	8
140	R:R:D220	R:R:F221	3.58	No	No	0	7	4
141	R:R:F221	R:R:L224	4.87	No	No	0	4	7
142	R:R:T226	R:R:W282	6.06	No	No	0	8	7
143	R:R:I231	R:R:V227	3.07	No	No	0	7	8
144	R:R:I278	R:R:V229	3.07	No	No	0	8	7
145	R:R:L230	R:R:Y279	3.52	No	Yes	0	8	9
146	R:R:I278	R:R:S233	3.1	No	No	0	8	7
147	R:R:C237	R:R:N271	9.45	No	No	0	7	9
148	R:R:F241	R:R:W238	6.01	Yes	Yes	1	6	8
149	R:R:G268	R:R:W238	11.26	No	Yes	0	7	8
150	L:L:?1	R:R:W238	7.76	Yes	Yes	1	0	8
151	R:R:P240	R:R:T239	3.5	No	No	0	9	4
152	R:R:L264	R:R:P240	3.28	No	No	0	4	9
153	R:R:F241	R:R:L260	6.09	Yes	No	0	6	4
154	R:R:F241	R:R:L264	3.65	Yes	No	0	6	4
155	L:L:?1	R:R:F241	6.23	Yes	Yes	1	0	6
156	R:R:L256	R:R:T244	4.42	Yes	No	0	5	4
157	R:R:L260	R:R:T244	7.37	No	No	0	4	4
158	R:R:L264	R:R:T244	4.42	No	No	0	4	4
159	R:R:L256	R:R:Q248	7.99	Yes	No	0	5	3
160	R:R:Q248	R:R:Y257	15.78	No	No	0	3	4
161	R:R:E253	R:R:H255	4.92	No	No	0	2	2
162	R:R:C254	R:R:Y257	8.06	No	No	0	4	4
163	R:R:V259	R:R:Y263	5.05	No	No	0	1	4
164	L:L:?1	R:R:E261	9.78	Yes	Yes	1	0	4
165	R:R:V269	R:R:W265	6.13	No	Yes	0	6	3
166	L:L:?1	R:R:W265	28.46	Yes	Yes	0	0	3
167	R:R:N271	R:R:N275	8.17	No	Yes	0	9	9
168	R:R:I278	R:R:Y279	6.04	No	Yes	0	8	9
169	R:R:R287	R:R:Y281	9.26	No	No	5	8	5
170	R:R:Y281	R:R:Y291	3.97	No	No	5	5	2
171	R:R:Q283	R:R:V286	7.16	No	No	0	8	9
172	R:R:R287	R:R:Y291	9.26	No	No	5	8	2
173	R:R:H292	R:R:Q289	3.71	No	Yes	0	5	7
174	R:R:M293	R:R:Q289	4.08	No	Yes	0	5	7
175	R:R:K299	R:R:L295	4.23	No	No	0	6	3
176	R:R:K298	R:R:K299	4.31	No	No	0	4	6
177	R:R:M117	R:R:V121	3.04	No	No	0	7	6
178	R:R:K152	R:R:V160	3.04	No	No	0	1	5
179	R:R:A28	R:R:Q289	3.03	No	Yes	0	7	7
180	R:R:L274	R:R:S233	3	No	No	0	5	7
181	R:R:L94	R:R:V132	2.98	No	No	0	5	3
182	R:R:L189	R:R:V227	2.98	No	No	0	7	8
183	R:R:L256	R:R:V247	2.98	Yes	No	0	5	4
184	R:R:L256	R:R:V259	2.98	Yes	No	0	5	1
185	R:R:I107	R:R:I191	2.94	No	No	0	8	6
186	R:R:N22	R:R:T21	2.92	Yes	No	0	9	8
187	R:R:I107	R:R:M188	2.92	No	No	0	8	9
188	R:R:I116	R:R:K115	2.91	No	No	0	5	4
189	R:R:G210	R:R:Y212	2.9	No	No	0	1	1
190	R:R:I99	R:R:L47	2.85	No	Yes	0	9	9
191	R:R:Q74	R:R:T76	2.83	No	No	0	7	2
192	R:R:A122	R:R:F43	2.77	No	Yes	0	6	8
193	R:R:L61	R:R:Q65	2.66	No	No	0	5	4
194	R:R:E285	R:R:L32	2.65	No	Yes	0	6	7
195	R:R:H195	R:R:I191	2.65	No	No	0	8	6
196	R:R:F138	R:R:S87	2.64	No	No	0	4	5
197	R:R:F157	R:R:V166	2.62	Yes	No	1	4	6
198	R:R:F158	R:R:V166	2.62	Yes	No	1	3	6
199	R:R:F161	R:R:V160	2.62	No	No	0	4	5
200	R:R:F165	R:R:V166	2.62	No	No	1	6	6
201	R:R:F5	R:R:L66	2.44	No	Yes	0	4	5
202	R:R:F7	R:R:L266	2.44	Yes	No	0	5	5
203	R:R:F184	R:R:L180	2.44	Yes	No	0	6	5
204	R:R:L258	R:R:R262	2.43	No	No	0	1	3
205	R:R:F146	R:R:Q147	2.34	Yes	No	0	2	1
206	R:R:Q197	R:R:R200	2.34	No	No	0	5	4
207	R:R:L290	R:R:Y281	2.34	No	No	0	5	5
208	R:R:L53	R:R:W130	2.28	No	Yes	0	8	9
209	R:R:G210	R:R:G211	2.11	No	No	0	1	3
210	R:R:G153	R:R:P72	2.03	No	No	0	3	3
211	R:R:A122	R:R:G123	1.95	No	No	0	6	1
212	R:R:A127	R:R:G128	1.95	No	No	0	3	3
213	R:R:A205	R:R:G206	1.95	No	No	0	4	2
214	R:R:A209	R:R:G206	1.95	No	No	0	3	2
215	R:R:G119	R:R:V39	1.84	No	No	0	1	5
216	R:R:A26	R:R:A48	1.79	No	No	0	7	9
217	L:L:?1	R:R:A89	1.79	Yes	No	0	0	6
218	L:L:?1	R:R:A90	1.79	Yes	No	0	0	7
219	R:R:A192	R:R:A223	1.79	No	No	0	8	8
220	R:R:P276	R:R:V25	1.77	No	Yes	0	9	9
221	R:R:G8	R:R:L62	1.71	No	No	0	4	6
222	R:R:G128	R:R:L131	1.71	No	No	0	3	3
223	R:R:G142	R:R:L141	1.71	No	No	0	5	6
224	R:R:C186	R:R:V182	1.71	No	No	0	3	5
225	R:R:G232	R:R:L236	1.71	No	No	0	5	4
226	R:R:G245	R:R:L260	1.71	No	No	0	6	4
227	R:R:G268	R:R:L267	1.71	No	No	0	7	7
228	R:R:G270	R:R:L273	1.71	No	No	0	5	5
229	R:R:G296	R:R:L295	1.71	No	No	0	4	3
230	R:R:A48	R:R:V25	1.7	No	Yes	0	9	9
231	R:R:A280	R:R:V286	1.7	No	No	0	8	9
232	R:R:A280	R:R:T44	1.68	No	No	0	8	7
233	R:R:A235	R:R:T239	1.68	No	No	0	6	4
234	R:R:C42	R:R:I126	1.64	No	No	0	4	7
235	R:R:V25	R:R:V29	1.6	Yes	No	0	9	8
236	R:R:T23	R:R:V27	1.59	No	No	0	5	5
237	R:R:T52	R:R:V56	1.59	No	No	0	6	4
238	R:R:A28	R:R:L290	1.58	No	No	0	7	5
239	R:R:P110	R:R:Q109	1.58	No	No	0	8	5
240	R:R:P163	R:R:Q148	1.58	No	No	0	3	4
241	R:R:A223	R:R:L189	1.58	No	No	0	8	7
242	R:R:A235	R:R:L236	1.58	No	No	0	6	4
243	R:R:I10	R:R:V9	1.54	No	No	0	4	5
244	R:R:K75	R:R:S79	1.53	No	No	0	3	4
245	R:R:I243	R:R:T239	1.52	No	No	0	5	4
246	R:R:C251	R:R:E253	1.52	No	No	0	4	2
247	R:R:K298	R:R:V297	1.52	No	No	0	4	3
248	R:R:F7	R:R:G8	1.51	Yes	No	0	5	4
249	R:R:L41	R:R:S40	1.5	No	No	0	9	8
250	R:R:L66	R:R:S67	1.5	Yes	No	0	5	5
251	R:R:L66	R:R:V9	1.49	Yes	No	0	5	5
252	R:R:L17	R:R:V13	1.49	No	No	0	4	4
253	R:R:L32	R:R:V286	1.49	Yes	No	0	7	9
254	R:R:L45	R:R:V49	1.49	No	No	0	6	6
255	R:R:L80	R:R:T76	1.47	No	No	0	5	2
256	R:R:L230	R:R:T226	1.47	No	No	0	8	8
257	R:R:P72	R:R:R71	1.44	No	No	0	3	6
258	R:R:F175	R:R:P176	1.44	No	No	0	5	5
259	R:R:I10	R:R:L14	1.43	No	No	0	4	5
260	R:R:K284	R:R:L288	1.41	No	No	0	5	4
261	R:R:L17	R:R:L273	1.38	No	No	0	4	5
262	R:R:L141	R:R:L80	1.38	No	No	0	6	5
263	R:R:L32	R:R:N36	1.37	Yes	No	0	7	9
264	R:R:K201	R:R:Q198	1.36	No	No	0	5	5
265	R:R:M202	R:R:Q198	1.36	No	No	0	4	5
266	R:R:A150	R:R:Y151	1.33	No	No	0	2	4
267	R:R:R225	R:R:T226	1.29	No	No	0	6	8
268	R:R:H255	R:R:L256	1.29	No	Yes	0	2	5
269	R:R:Q154	R:R:Y151	1.13	No	No	0	2	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F7	8.088	5	0	5
2	R:R:N22	7.23	4	2	9
3	R:R:V25	2.54	4	0	9
4	R:R:L32	2.7075	4	0	7
5	R:R:F43	5.865	4	0	8
6	R:R:L47	4.66	5	2	9
7	R:R:D51	6.78833	6	2	9
8	R:R:I54	5.14	4	0	8
9	R:R:L66	2.2125	4	0	5
10	R:R:Y104	12.1825	4	4	8
11	R:R:W130	5.2075	4	0	9
12	R:R:F146	5.048	5	1	2
13	R:R:F157	11.386	5	1	4
14	R:R:F158	6.97	4	1	3
15	R:R:F184	7.956	5	0	6
16	R:R:Y185	7.06667	6	3	9
17	R:R:F234	10.4975	4	0	9
18	R:R:W238	7.26	4	1	8
19	R:R:F241	5.495	4	1	6
20	R:R:L256	3.932	5	0	5
21	R:R:E261	7.45	4	1	4
22	R:R:W265	10.9625	4	0	3
23	R:R:N275	6.205	4	2	9
24	R:R:Y279	4.198	5	0	9
25	R:R:Q289	4.292	5	0	7
26	L:L:?1	8.89286	14	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F7	R:R:G8	15.7863	1.51	Yes	No	0	5	4
2	R:R:G8	R:R:L66	10.5673	3.42	No	Yes	0	4	5
3	R:R:L11	R:R:W265	10.6698	4.56	No	Yes	0	6	3
4	R:R:I58	R:R:W265	97.1355	4.7	No	Yes	0	7	3
5	L:L:?1	R:R:W265	86.0242	28.46	Yes	Yes	0	0	3
6	L:L:?1	R:R:F7	13.1243	4.15	Yes	Yes	0	0	5
7	R:R:I58	R:R:V85	98.4092	3.07	No	No	0	7	7
8	R:R:A57	R:R:V85	98.8142	3.39	No	No	0	4	7
9	R:R:A57	R:R:F84	99.2143	5.55	No	No	0	4	3
10	R:R:F84	R:R:S88	99.6096	3.96	No	No	0	3	6
11	R:R:I54	R:R:S88	100	3.1	Yes	No	0	8	6
12	R:R:I54	R:R:S272	51.2871	9.29	Yes	No	0	8	9
13	R:R:D51	R:R:S92	49.9207	4.42	Yes	No	0	9	9
14	R:R:I54	R:R:S92	49.9109	4.64	Yes	No	0	8	9
15	R:R:D51	R:R:S272	51.3163	8.83	Yes	No	0	9	9
16	R:R:D51	R:R:P276	29.2034	3.22	Yes	No	2	9	9
17	R:R:A280	R:R:V25	19.1899	5.09	No	Yes	0	8	9
18	R:R:P276	R:R:V25	28.5836	1.77	No	Yes	0	9	9
19	R:R:A280	R:R:V286	17.2527	1.7	No	No	0	8	9
20	R:R:L32	R:R:V286	15.2958	1.49	Yes	No	0	7	9
21	R:R:L32	R:R:Q289	11.3237	5.32	Yes	Yes	0	7	7
22	R:R:F43	R:R:I126	13.3829	5.02	Yes	No	0	8	7
23	R:R:I126	R:R:N46	15.369	11.33	No	No	0	7	9
24	R:R:N46	R:R:T95	25.9436	8.77	No	No	0	9	8
25	R:R:L47	R:R:T95	30.5551	7.37	Yes	No	0	9	8
26	R:R:D51	R:R:L47	73.744	4.07	Yes	Yes	2	9	9
27	R:R:N46	R:R:W130	10.3672	7.91	No	Yes	0	9	9
28	R:R:D51	R:R:N275	11.8922	6.73	Yes	Yes	2	9	9
29	R:R:L47	R:R:Y279	53.4025	3.52	Yes	Yes	0	9	9
30	L:L:?1	R:R:M82	16.8013	3.21	Yes	No	0	0	5
31	R:R:C78	R:R:M82	15.8863	3.24	No	No	0	9	5
32	R:R:C155	R:R:C78	14.9299	7.28	No	No	0	9	9
33	R:R:C155	R:R:T73	13.9685	8.45	No	No	0	9	5
34	R:R:L77	R:R:T73	13.0023	4.42	No	No	0	4	5
35	R:R:L77	R:R:R81	12.0312	10.93	No	No	0	4	6
36	L:L:?1	R:R:F157	26.4682	24.9	Yes	Yes	1	0	4
37	R:R:N275	R:R:V96	10.6185	4.43	Yes	No	0	9	9
38	R:R:R103	R:R:Y279	23.4793	4.12	No	Yes	0	9	9
39	R:R:R103	R:R:Y185	22.64	5.14	No	Yes	0	9	9
40	R:R:T100	R:R:Y185	10.8284	7.49	No	Yes	3	8	9
41	R:R:L230	R:R:Y279	26.2169	3.52	No	Yes	0	8	9
42	R:R:L230	R:R:Y185	22.8596	10.55	No	Yes	0	8	9
43	R:R:F184	R:R:T100	13.2463	3.89	Yes	No	0	6	8
44	R:R:M188	R:R:Y185	20.4611	7.18	No	Yes	0	9	9
45	R:R:M188	R:R:Y104	11.2871	4.79	No	Yes	0	9	8
46	R:R:F157	R:R:V166	11.736	2.62	Yes	No	1	4	6
47	R:R:F165	R:R:V166	10.9211	2.62	No	No	1	6	6
48	R:R:V227	R:R:Y185	13.1829	3.79	No	Yes	0	8	9
49	L:L:?1	R:R:F241	30.2916	6.23	Yes	Yes	1	0	6
50	R:R:F241	R:R:L264	17.5991	3.65	Yes	No	0	6	4
51	R:R:F241	R:R:L260	12.7193	6.09	Yes	No	0	6	4
52	R:R:L260	R:R:T244	10.821	7.37	No	No	0	4	4
53	R:R:L256	R:R:T244	19.7609	4.42	Yes	No	0	5	4
54	R:R:L264	R:R:T244	10.9552	4.42	No	No	0	4	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F7	R:R:L11	10.96	0	Yes	No	5	6	1	2
R:R:F7	R:R:R262	21.38	0	Yes	No	5	3	1	2
L:L:?1	R:R:F7	4.15	1	Yes	Yes	0	5	0	1
R:R:L11	R:R:W265	4.56	0	No	Yes	6	3	2	1
R:R:I58	R:R:W265	4.7	0	No	Yes	7	3	2	1
R:R:C78	R:R:M82	3.24	0	No	No	9	5	2	1
L:L:?1	R:R:M82	3.21	1	Yes	No	0	5	0	1
L:L:?1	R:R:T86	6.7	1	Yes	No	0	5	0	1
L:L:?1	R:R:V93	9.31	1	Yes	No	0	7	0	1
R:R:E261	R:R:S156	7.19	1	Yes	No	4	4	1	2
R:R:F157	R:R:F158	13.93	1	Yes	Yes	4	3	1	2
R:R:F157	R:R:F161	9.65	1	Yes	No	4	4	1	2
R:R:E261	R:R:F157	5.83	1	Yes	Yes	4	4	1	1
L:L:?1	R:R:F157	24.9	1	Yes	Yes	0	4	0	1
R:R:E261	R:R:F158	7	1	Yes	Yes	4	3	1	2
L:L:?1	R:R:L169	11	1	Yes	No	0	6	0	1
L:L:?1	R:R:G173	3.89	1	Yes	No	0	6	0	1
R:R:F174	R:R:F175	4.29	1	No	No	8	5	1	2
R:R:F174	R:R:W238	4.01	1	No	Yes	8	8	1	1
L:L:?1	R:R:F174	5.53	1	Yes	No	0	8	0	1
R:R:F241	R:R:W238	6.01	1	Yes	Yes	6	8	1	1
R:R:G268	R:R:W238	11.26	0	No	Yes	7	8	2	1
L:L:?1	R:R:W238	7.76	1	Yes	Yes	0	8	0	1
R:R:F241	R:R:L260	6.09	1	Yes	No	6	4	1	2
R:R:F241	R:R:L264	3.65	1	Yes	No	6	4	1	2
L:L:?1	R:R:F241	6.23	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:E261	9.78	1	Yes	Yes	0	4	0	1
R:R:V269	R:R:W265	6.13	0	No	Yes	6	3	2	1
L:L:?1	R:R:W265	28.46	1	Yes	Yes	0	3	0	1
R:R:F157	R:R:V166	2.62	1	Yes	No	4	6	1	2
R:R:F158	R:R:V166	2.62	1	Yes	No	3	6	2	2
R:R:F7	R:R:L266	2.44	0	Yes	No	5	5	1	2
L:L:?1	R:R:A89	1.79	1	Yes	No	0	6	0	1
L:L:?1	R:R:A90	1.79	1	Yes	No	0	7	0	1
R:R:F7	R:R:G8	1.51	0	Yes	No	5	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7WCM_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.07
Number of Linked Nodes	260
Number of Links	269
Number of Hubs	26
Number of Links mediated by Hubs	109
Number of Communities	5
Number of Nodes involved in Communities	25
Number of Links involved in Communities	31

Path Summary
Number Of Nodes in MetaPath	55
Number Of Links MetaPath	54
Number of Shortest Paths	59444
Length Of Smallest Path	3
Average Path Length	16.3106
Length of Longest Path	33
Minimum Path Strength	1.23
Average Path Strength	6.12366
Maximum Path Strength	22.43
Minimum Path Correlation	0.7
Average Path Correlation	0.955425
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	5.88235
Average % Of Corr. Nodes	54.8124
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	36.812
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • cation binding • ion binding • phosphatidylcholine binding • phospholipid binding • lipid binding • quaternary ammonium group binding • small molecule binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • metabolic process • regulation of metabolic process • protein localization • establishment of protein localization • cellular localization • nitrogen compound transport • transport • hormone secretion • protein localization to extracellular region • peptide secretion • localization • secretion by cell • amide transport • signal release • cellular macromolecule localization • regulation of biological quality • secretion • regulation of hormone levels • establishment of protein localization to extracellular region • export from cell • protein secretion • establishment of localization • peptide transport • protein transport • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • receptor complex
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	8VP
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	8VP
Name	MBX-2982
Synonyms	MBX-2982
Identifier
Formula	C22 H24 N8 O S
Molecular Weight	448.544
SMILES
PubChem	25025505
Formal Charge	0
Total Atoms	56
Total Chiral Atoms	0
Total Bonds	60
Total Aromatic Bonds	22


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDV5
Sequence	>7WCM_nogp_Chain_R F S F G V I L A V L A S L I I A T N T L V A V A V L L L I H K N D G V S L C F T L N L A V A D T L I G V A I S G L L T D Q L S S P S R P T Q K T L C S L R M A F V T S S A A A S V L T V M L I T F D R Y L A I K Q P F R Y L K I M S G F V A G A C I A G L W L V S Y L I G F L P L G I P M F Q Q T A Y K G Q C S F F A V F H P H F V L T L S C V G F F P A M L L F V F F Y C D M L K I A S M H S Q Q I R K M E H A G A M A G G Y D F K A L R T V S V L I G S F A L C W T P F L I T G I V Q V A C Q E C H L Y L V L E R Y L W L L G V G N S L L N P L I Y A Y W Q K E V R L Q L Y H M A L G V K K V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8VHF	A	Lipid	GPR119	GPR119	Homo sapiens	MBX-2982	-	Gs/β1/γ2	3.51	2024-10-30	doi.org/10.1016/j.str.2024.10.004
	8VHF (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	MBX-2982	-		3.51	2024-10-30	doi.org/10.1016/j.str.2024.10.004
	8ZRK	A	Lipid	GPR119	GPR119	Homo sapiens	GSK-1292263	-	Gs/β1/γ2	2.82	2024-06-19	To be published
	8ZRK (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	GSK-1292263	-		2.82	2024-06-19	To be published
	8ZR5	A	Lipid	GPR119	GPR119	Homo sapiens	Firuglipel	-	Gs/β1/γ2	3.31	2024-06-19	To be published
	8ZR5 (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	Firuglipel	-		3.31	2024-06-19	To be published
	7WCN	A	Lipid	GPR119	GPR119	Homo sapiens	AR231453	-	Gs/β1/γ2	2.87	2022-12-21	10.1038/s41467-022-34696-6
	7WCN (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	AR231453	-		2.87	2022-12-21	10.1038/s41467-022-34696-6
	7WCM	A	Lipid	GPR119	GPR119	Homo sapiens	MBX-2982	-	Gs/β1/γ2	2.33	2022-12-21	10.1038/s41467-022-34696-6
	7WCM (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	MBX-2982	-		2.33	2022-12-21	10.1038/s41467-022-34696-6
	7XZ6	A	Lipid	GPR119	GPR119	Homo sapiens	APD668	-	Gs/β1/γ2	2.8	2022-08-24	10.1038/s41594-022-00816-5
	7XZ6 (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	APD668	-		2.8	2022-08-24	10.1038/s41594-022-00816-5
	7XZ5	A	Lipid	GPR119	GPR119	Homo sapiens	Lysophosphatidylcholine	-	Gs/β1/γ2	3.1	2022-08-24	10.1038/s41594-022-00816-5
	7XZ5 (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	Lysophosphatidylcholine	-		3.1	2022-08-24	10.1038/s41594-022-00816-5

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