psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L61	3.98	Yes	No	1	0	5
2	L:L:?1	R:R:Q65	3.82	Yes	Yes	1	0	4
3	L:L:?1	R:R:M82	7.45	Yes	No	0	0	5
4	L:L:?1	R:R:V85	4.28	Yes	No	1	0	7
5	L:L:?1	R:R:T86	9.18	Yes	No	0	0	5
6	L:L:?1	R:R:A89	4.53	Yes	No	1	0	6
7	L:L:?1	R:R:V93	8.56	Yes	No	1	0	7
8	L:L:?1	R:R:F157	28	Yes	Yes	1	0	4
9	L:L:?1	R:R:L169	7.29	Yes	No	0	0	6
10	L:L:?1	R:R:F174	7.58	Yes	Yes	1	0	8
11	L:L:?1	R:R:W238	21.27	Yes	Yes	1	0	8
12	L:L:?1	R:R:F241	5.83	Yes	Yes	1	0	6
13	L:L:?1	R:R:W265	26.18	Yes	Yes	1	0	3
14	R:R:F7	R:R:L11	8.53	Yes	Yes	1	5	6
15	R:R:F7	R:R:Q65	11.71	Yes	Yes	1	5	4
16	R:R:F7	R:R:R262	19.24	Yes	Yes	1	5	3
17	R:R:F7	R:R:W265	5.01	Yes	Yes	1	5	3
18	R:R:I58	R:R:L11	5.71	No	Yes	0	7	6
19	R:R:L11	R:R:W265	6.83	Yes	Yes	1	6	3
20	R:R:A12	R:R:L62	4.73	No	No	0	4	6
21	R:R:I18	R:R:L14	7.14	Yes	No	0	8	5
22	R:R:L14	R:R:V269	4.47	No	No	0	5	6
23	R:R:L17	R:R:L273	4.15	No	No	0	4	5
24	R:R:I18	R:R:N22	4.25	Yes	Yes	0	8	9
25	R:R:I18	R:R:S272	4.64	Yes	No	0	8	9
26	R:R:I18	R:R:L273	5.71	Yes	No	0	8	5
27	R:R:D51	R:R:N22	13.46	Yes	Yes	0	9	9
28	R:R:N22	R:R:T52	4.39	Yes	No	0	9	6
29	R:R:N22	R:R:P276	13.03	Yes	No	0	9	9
30	R:R:L24	R:R:L290	4.15	No	Yes	0	8	5
31	R:R:A280	R:R:V25	5.09	No	No	0	8	9
32	R:R:T44	R:R:V29	4.76	No	No	0	7	8
33	R:R:L30	R:R:L45	6.92	No	No	0	3	6
34	R:R:L31	R:R:Q289	10.65	No	Yes	0	5	7
35	R:R:L32	R:R:N36	5.49	Yes	No	0	7	9
36	R:R:E285	R:R:L32	3.98	No	Yes	0	6	7
37	R:R:L32	R:R:Q289	7.99	Yes	Yes	0	7	7
38	R:R:I33	R:R:L41	4.28	No	No	0	7	9
39	R:R:K35	R:R:Q289	5.42	No	Yes	0	6	7
40	R:R:M117	R:R:V39	7.61	No	No	0	7	5
41	R:R:D102	R:R:S40	4.42	No	No	0	9	8
42	R:R:F43	R:R:L98	12.18	Yes	No	0	8	7
43	R:R:F43	R:R:I99	3.77	Yes	No	0	8	9
44	R:R:D102	R:R:F43	9.55	No	Yes	0	9	8
45	R:R:N46	R:R:T95	10.24	Yes	No	3	9	8
46	R:R:I126	R:R:N46	11.33	No	Yes	0	7	9
47	R:R:L129	R:R:N46	5.49	No	Yes	3	6	9
48	R:R:N46	R:R:W130	9.04	Yes	Yes	0	9	9
49	R:R:L47	R:R:T95	5.9	Yes	No	0	9	8
50	R:R:I99	R:R:L47	4.28	No	Yes	0	9	9
51	R:R:L47	R:R:N275	6.87	Yes	Yes	0	9	9
52	R:R:L47	R:R:Y279	4.69	Yes	Yes	0	9	9
53	R:R:D51	R:R:S92	5.89	Yes	No	2	9	9
54	R:R:D51	R:R:S272	8.83	Yes	No	0	9	9
55	R:R:D51	R:R:N275	10.77	Yes	Yes	2	9	9
56	R:R:I54	R:R:S88	4.64	No	No	0	8	6
57	R:R:I54	R:R:S272	9.29	No	No	0	8	9
58	R:R:A57	R:R:F84	5.55	No	No	0	4	3
59	R:R:I58	R:R:V269	6.14	No	No	0	7	6
60	R:R:L61	R:R:V85	4.47	No	No	1	5	7
61	R:R:D64	R:R:Q65	10.44	Yes	Yes	1	4	4
62	R:R:D64	R:R:R81	4.76	Yes	Yes	1	4	6
63	R:R:C155	R:R:D64	7.78	Yes	Yes	1	9	4
64	R:R:Q65	R:R:R262	9.35	Yes	Yes	1	4	3
65	R:R:Q74	R:R:S70	5.78	Yes	No	0	7	4
66	R:R:Q154	R:R:S70	4.33	No	No	0	2	4
67	R:R:Q74	R:R:R81	4.67	Yes	Yes	1	7	6
68	R:R:C155	R:R:Q74	4.58	Yes	Yes	1	9	7
69	R:R:K75	R:R:Y151	15.53	No	No	0	3	4
70	R:R:C78	R:R:R81	4.18	No	Yes	1	9	6
71	R:R:C155	R:R:C78	7.28	Yes	No	1	9	9
72	R:R:L141	R:R:S79	6.01	No	No	0	6	4
73	R:R:S79	R:R:V160	4.85	No	No	1	4	5
74	R:R:F161	R:R:S79	5.28	Yes	No	1	4	4
75	R:R:C155	R:R:R81	5.57	Yes	Yes	1	9	6
76	R:R:A83	R:R:F138	8.32	No	Yes	0	6	4
77	R:R:F84	R:R:S88	5.28	No	No	0	3	6
78	R:R:S87	R:R:Y134	8.9	No	No	4	5	4
79	R:R:F138	R:R:S87	5.28	Yes	No	4	4	5
80	R:R:A89	R:R:W238	3.89	No	Yes	1	6	8
81	R:R:A91	R:R:W130	3.89	No	Yes	0	7	9
82	R:R:N275	R:R:S92	4.47	Yes	No	2	9	9
83	R:R:F174	R:R:V93	3.93	Yes	No	1	8	7
84	R:R:L129	R:R:L94	5.54	No	No	0	6	5
85	R:R:L129	R:R:T95	7.37	No	No	3	6	8
86	R:R:F234	R:R:V96	5.24	Yes	No	0	9	9
87	R:R:N275	R:R:V96	4.43	Yes	No	0	9	9
88	R:R:V96	R:R:Y279	8.83	No	Yes	0	9	9
89	R:R:A177	R:R:M97	4.83	No	No	0	8	7
90	R:R:F181	R:R:M97	4.98	Yes	No	1	8	7
91	R:R:F234	R:R:M97	6.22	Yes	No	1	9	7
92	R:R:C125	R:R:L98	4.76	No	No	0	6	7
93	R:R:I99	R:R:R103	5.01	No	No	0	9	9
94	R:R:F181	R:R:T100	11.67	Yes	No	1	8	8
95	R:R:F184	R:R:T100	3.89	Yes	No	0	6	8
96	R:R:T100	R:R:Y185	13.73	No	Yes	1	8	9
97	R:R:D102	R:R:Y113	10.34	No	Yes	0	9	9
98	R:R:R103	R:R:Y185	6.17	No	Yes	0	9	9
99	R:R:R103	R:R:Y279	5.14	No	Yes	0	9	9
100	R:R:K108	R:R:Y104	5.97	No	No	0	6	8
101	R:R:F184	R:R:Y104	19.6	Yes	No	0	6	8
102	R:R:D187	R:R:Y104	10.34	No	No	0	5	8
103	R:R:L105	R:R:Y113	7.03	No	Yes	0	5	9
104	R:R:A106	R:R:Y113	8.01	No	Yes	0	9	9
105	R:R:I107	R:R:M188	5.83	No	No	0	8	9
106	R:R:I107	R:R:I191	5.89	No	No	0	8	6
107	R:R:K108	R:R:Q109	5.42	No	No	0	6	5
108	R:R:Q109	R:R:R112	12.85	No	No	0	5	5
109	R:R:M117	R:R:Y113	11.97	No	Yes	0	7	9
110	R:R:F138	R:R:Y134	4.13	Yes	No	4	4	4
111	R:R:I143	R:R:L139	4.28	No	No	1	4	4
112	R:R:F146	R:R:L139	6.09	Yes	No	1	2	4
113	R:R:F146	R:R:P140	4.33	Yes	No	1	2	5
114	R:R:F161	R:R:P140	14.45	Yes	No	1	4	5
115	R:R:F165	R:R:P140	18.78	Yes	No	1	6	5
116	R:R:F146	R:R:I143	13.82	Yes	No	1	2	4
117	R:R:F146	R:R:M145	6.22	Yes	No	0	2	3
118	R:R:F146	R:R:F165	7.5	Yes	Yes	1	2	6
119	R:R:F146	R:R:T168	10.38	Yes	No	0	2	4
120	R:R:H162	R:R:Q148	7.42	No	No	0	5	4
121	R:R:G153	R:R:Y151	5.79	No	No	0	3	4
122	R:R:V160	R:R:Y151	3.79	No	No	0	5	4
123	R:R:E261	R:R:S156	7.19	No	No	0	4	4
124	R:R:F157	R:R:F158	10.72	Yes	Yes	1	4	3
125	R:R:F157	R:R:F161	6.43	Yes	Yes	1	4	4
126	R:R:F157	R:R:F165	4.29	Yes	Yes	1	4	6
127	R:R:F158	R:R:P163	4.33	Yes	No	1	3	3
128	R:R:F158	R:R:Y257	11.35	Yes	No	1	3	4
129	R:R:F158	R:R:L260	7.31	Yes	No	0	3	4
130	R:R:E261	R:R:F158	7	No	Yes	0	4	3
131	R:R:F161	R:R:V160	10.49	Yes	No	1	4	5
132	R:R:F161	R:R:F165	4.29	Yes	Yes	1	4	6
133	R:R:H162	R:R:P163	9.15	No	No	0	5	3
134	R:R:H162	R:R:H164	13.14	No	No	0	5	2
135	R:R:P163	R:R:Y257	6.95	No	No	1	3	4
136	R:R:H164	R:R:V249	4.15	No	No	0	2	4
137	R:R:I246	R:R:L167	4.28	No	No	0	5	5
138	R:R:F175	R:R:S170	3.96	No	No	0	5	6
139	R:R:L242	R:R:S170	10.51	No	No	0	6	6
140	R:R:F174	R:R:F234	6.43	Yes	Yes	1	8	9
141	R:R:F174	R:R:S237	3.96	Yes	No	1	8	7
142	R:R:F174	R:R:W238	11.02	Yes	Yes	1	8	8
143	R:R:F174	R:R:T239	5.19	Yes	Yes	0	8	4
144	R:R:F174	R:R:L242	6.09	Yes	No	0	8	6
145	R:R:F175	R:R:I243	3.77	No	No	0	5	5
146	R:R:F234	R:R:M178	4.98	Yes	No	0	9	5
147	R:R:M178	R:R:T239	4.52	No	Yes	0	5	4
148	R:R:F184	R:R:L180	6.09	Yes	No	0	6	5
149	R:R:F181	R:R:Y185	15.47	Yes	Yes	1	8	9
150	R:R:F181	R:R:I231	3.77	Yes	No	0	8	7
151	R:R:F181	R:R:F234	24.65	Yes	Yes	1	8	9
152	R:R:F183	R:R:F184	5.36	No	Yes	0	3	6
153	R:R:M188	R:R:Y185	9.58	No	Yes	0	9	9
154	R:R:L230	R:R:Y185	8.21	No	Yes	0	8	9
155	R:R:D187	R:R:I191	4.2	No	No	0	5	6
156	R:R:L189	R:R:V227	7.45	No	No	0	7	8
157	R:R:R200	R:R:S196	5.27	No	No	5	4	5
158	R:R:D220	R:R:S196	4.42	No	No	5	7	5
159	R:R:K201	R:R:Q198	8.14	No	No	0	5	5
160	R:R:D220	R:R:R200	11.91	No	No	5	7	4
161	R:R:R225	R:R:W282	5	No	No	0	6	7
162	R:R:T226	R:R:W282	8.49	No	No	0	8	7
163	R:R:N271	R:R:S233	5.96	No	No	0	9	7
164	R:R:S237	R:R:W238	8.65	No	Yes	1	7	8
165	R:R:N271	R:R:S237	8.94	No	No	0	9	7
166	R:R:F241	R:R:W238	5.01	Yes	Yes	1	6	8
167	R:R:G268	R:R:W238	12.67	No	Yes	0	7	8
168	R:R:F241	R:R:L260	10.96	Yes	No	0	6	4
169	R:R:F241	R:R:W265	4.01	Yes	Yes	1	6	3
170	R:R:L256	R:R:T244	4.42	No	No	0	5	4
171	R:R:L260	R:R:T244	7.37	No	No	0	4	4
172	R:R:L264	R:R:T244	4.42	No	No	0	4	4
173	R:R:C254	R:R:Q248	6.1	No	No	0	4	3
174	R:R:L256	R:R:Q248	9.32	No	No	0	5	3
175	R:R:Q248	R:R:Y257	13.53	No	No	0	3	4
176	R:R:C251	R:R:C254	7.28	No	No	0	4	4
177	R:R:E253	R:R:Q252	19.11	No	No	0	2	3
178	R:R:V259	R:R:Y263	5.05	No	No	0	1	4
179	R:R:E261	R:R:R262	10.47	No	Yes	0	4	3
180	R:R:R262	R:R:Y263	4.12	Yes	No	0	3	4
181	R:R:V269	R:R:W265	9.81	No	Yes	0	6	3
182	R:R:N271	R:R:N275	9.54	No	Yes	0	9	9
183	R:R:I278	R:R:Y279	4.84	No	Yes	0	8	9
184	R:R:R287	R:R:Y281	6.17	No	No	0	8	5
185	R:R:Q283	R:R:V286	4.3	No	Yes	0	8	9
186	R:R:H292	R:R:L288	9	No	No	0	5	4
187	R:R:M293	R:R:Q289	6.8	No	Yes	0	5	7
188	R:R:L290	R:R:M293	4.24	Yes	No	0	5	5
189	R:R:L295	R:R:Y291	18.76	No	No	0	3	2
190	R:R:G137	R:R:S87	3.71	No	No	0	7	5
191	R:R:G119	R:R:S118	3.71	No	No	0	1	8
192	R:R:V229	R:R:W282	3.68	No	No	0	7	7
193	R:R:F7	R:R:L266	3.65	Yes	No	0	5	5
194	R:R:F138	R:R:L80	3.65	Yes	No	0	4	5
195	R:R:G137	R:R:T86	3.64	No	No	0	7	5
196	R:R:P69	R:R:S68	3.56	No	No	0	5	4
197	R:R:G55	R:R:I19	3.53	No	No	0	8	6
198	R:R:P276	R:R:V25	3.53	No	No	0	9	9
199	R:R:G55	R:R:I54	3.53	No	No	0	8	8
200	R:R:P276	R:R:T21	3.5	No	No	0	9	8
201	R:R:Q197	R:R:R200	3.5	No	No	0	5	4
202	R:R:P240	R:R:T239	3.5	No	Yes	0	9	4
203	R:R:G270	R:R:L14	3.42	No	No	0	5	5
204	R:R:L53	R:R:W130	3.42	No	Yes	0	8	9
205	R:R:A90	R:R:S133	3.42	No	No	0	7	8
206	R:R:A91	R:R:S133	3.42	No	No	0	7	8
207	R:R:A48	R:R:V25	3.39	No	No	0	9	9
208	R:R:I143	R:R:P144	3.39	No	No	0	4	2
209	R:R:A280	R:R:V286	3.39	No	Yes	0	8	9
210	L:L:?1	R:R:G173	3.28	Yes	No	0	0	6
211	R:R:L267	R:R:P240	3.28	No	No	0	7	9
212	R:R:H292	R:R:Y291	3.27	No	No	0	5	2
213	R:R:A15	R:R:I58	3.25	No	No	0	6	7
214	R:R:S59	R:R:V56	3.23	No	No	0	7	4
215	R:R:F101	R:R:F184	3.22	No	Yes	0	5	6
216	R:R:C171	R:R:L167	3.17	No	No	0	4	5
217	R:R:A28	R:R:L290	3.15	No	Yes	0	7	5
218	R:R:T23	R:R:T52	3.14	No	No	0	5	6
219	R:R:I246	R:R:S170	3.1	No	No	0	5	6
220	R:R:I33	R:R:V29	3.07	No	No	0	7	8
221	R:R:I136	R:R:V132	3.07	No	No	0	6	3
222	R:R:I231	R:R:V227	3.07	No	No	0	7	8
223	R:R:L17	R:R:V13	2.98	No	No	0	4	4
224	R:R:L31	R:R:V27	2.98	No	No	0	5	5
225	R:R:L45	R:R:V29	2.98	No	No	0	6	8
226	R:R:L32	R:R:V286	2.98	Yes	Yes	0	7	9
227	R:R:L45	R:R:V49	2.98	No	No	0	6	6
228	R:R:L290	R:R:V286	2.98	Yes	Yes	0	5	9
229	R:R:L230	R:R:T226	2.95	No	No	0	8	8
230	R:R:P72	R:R:R71	2.88	No	No	0	3	6
231	R:R:A122	R:R:F43	2.77	No	Yes	0	6	8
232	R:R:M194	R:R:Q197	2.72	No	No	0	4	5
233	R:R:M202	R:R:Q198	2.72	No	No	0	4	5
234	R:R:H195	R:R:I191	2.65	No	No	0	8	6
235	R:R:E285	R:R:L288	2.65	No	No	0	6	4
236	R:R:F157	R:R:V166	2.62	Yes	Yes	1	4	6
237	R:R:F158	R:R:V166	2.62	Yes	Yes	1	3	6
238	R:R:F241	R:R:V166	2.62	Yes	Yes	1	6	6
239	R:R:R71	R:R:T73	2.59	No	No	0	6	5
240	R:R:I116	R:R:R112	2.51	No	No	0	5	5
241	R:R:K284	R:R:R287	2.48	No	No	0	5	8
242	R:R:V49	R:R:W130	2.45	No	Yes	0	6	9
243	R:R:F221	R:R:L224	2.44	No	No	0	4	7
244	R:R:L77	R:R:R81	2.43	No	Yes	0	4	6
245	R:R:L114	R:R:Y113	2.34	No	Yes	0	4	9
246	L:L:?1	R:R:I136	2.05	Yes	No	0	0	6
247	R:R:G173	R:R:P176	2.03	No	No	0	6	5
248	R:R:A122	R:R:G123	1.95	No	No	0	6	1
249	R:R:A127	R:R:G128	1.95	No	No	0	3	3
250	R:R:A205	R:R:G206	1.95	No	No	0	4	2
251	R:R:G60	R:R:S59	1.86	No	No	0	7	7
252	R:R:G245	R:R:V166	1.84	No	Yes	0	6	6
253	R:R:G173	R:R:V172	1.84	No	No	0	6	4
254	R:R:A122	R:R:C42	1.81	No	No	0	6	4
255	R:R:A26	R:R:A48	1.79	No	No	0	7	9
256	R:R:A50	R:R:A91	1.79	No	No	0	8	7
257	R:R:A192	R:R:A223	1.79	No	No	0	8	8
258	R:R:G8	R:R:L11	1.71	No	Yes	0	4	6
259	R:R:G8	R:R:L66	1.71	No	No	0	4	5
260	R:R:C125	R:R:V121	1.71	No	No	0	6	6
261	R:R:G128	R:R:L131	1.71	No	No	0	3	3
262	R:R:G142	R:R:L141	1.71	No	No	0	5	6
263	R:R:A159	R:R:S156	1.71	No	No	0	4	4
264	R:R:C186	R:R:V182	1.71	No	No	0	3	5
265	R:R:C251	R:R:V247	1.71	No	No	0	4	4
266	R:R:G296	R:R:L295	1.71	No	No	0	4	3
267	R:R:A150	R:R:T149	1.68	No	No	0	2	1
268	R:R:A235	R:R:T239	1.68	No	Yes	0	6	4
269	R:R:L236	R:R:P240	1.64	No	No	0	4	9
270	R:R:S228	R:R:V229	1.62	No	No	0	7	7
271	R:R:V13	R:R:V9	1.6	No	No	0	4	5
272	R:R:S68	R:R:T63	1.6	No	No	0	4	5
273	R:R:T52	R:R:V56	1.59	No	No	0	6	4
274	R:R:P110	R:R:Q109	1.58	No	No	0	8	5
275	R:R:A223	R:R:L189	1.58	No	No	0	8	7
276	R:R:I10	R:R:V9	1.54	No	No	0	4	5
277	R:R:I231	R:R:V182	1.54	No	No	0	7	5
278	R:R:L62	R:R:S59	1.5	No	No	0	6	7
279	R:R:D64	R:R:T63	1.45	Yes	No	0	4	5
280	R:R:I278	R:R:L274	1.43	No	No	0	8	5
281	R:R:A124	R:R:F120	1.39	No	No	0	2	3
282	R:R:L189	R:R:L224	1.38	No	No	0	7	7
283	R:R:K75	R:R:Q147	1.36	No	No	0	3	1
284	R:R:F120	R:R:V121	1.31	No	No	0	3	6
285	R:R:H34	R:R:L30	1.29	No	No	0	6	3
286	R:R:F5	R:R:L66	1.22	No	No	0	4	5
287	R:R:L258	R:R:R262	1.21	No	Yes	0	1	3
288	R:R:Q74	R:R:R71	1.17	Yes	No	0	7	6
289	R:R:L277	R:R:Y281	1.17	No	No	0	6	5
290	R:R:L290	R:R:Y281	1.17	Yes	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.552	15	1	0
2	R:R:F7	9.628	5	1	5
3	R:R:L11	5.695	4	1	6
4	R:R:I18	5.435	4	0	8
5	R:R:N22	8.7825	4	0	9
6	R:R:L32	5.11	4	0	7
7	R:R:F43	7.0675	4	0	8
8	R:R:N46	9.025	4	3	9
9	R:R:L47	5.435	4	0	9
10	R:R:D51	9.7375	4	2	9
11	R:R:D64	6.1075	4	1	4
12	R:R:Q65	8.83	4	1	4
13	R:R:Q74	4.05	4	1	7
14	R:R:R81	4.322	5	1	6
15	R:R:Y113	7.938	5	0	9
16	R:R:W130	4.7	4	0	9
17	R:R:F138	5.345	4	4	4
18	R:R:F146	8.05667	6	1	2
19	R:R:C155	6.3025	4	1	9
20	R:R:F157	10.412	5	1	4
21	R:R:F158	7.22167	6	1	3
22	R:R:F161	8.188	5	1	4
23	R:R:F165	8.715	4	1	6
24	R:R:V166	2.425	4	1	6
25	R:R:F174	6.31429	7	1	8
26	R:R:F181	12.108	5	1	8
27	R:R:F184	7.632	5	0	6
28	R:R:Y185	10.632	5	1	9
29	R:R:F234	9.504	5	1	9
30	R:R:W238	10.4183	6	1	8
31	R:R:T239	3.7225	4	0	4
32	R:R:F241	5.686	5	1	6
33	R:R:R262	8.878	5	1	3
34	R:R:W265	10.368	5	1	3
35	R:R:N275	7.216	5	2	9
36	R:R:Y279	5.875	4	0	9
37	R:R:V286	3.4125	4	0	9
38	R:R:Q289	7.715	4	0	7
39	R:R:L290	3.138	5	0	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Q65	53.9322	3.82	Yes	Yes	1	0	4
2	L:L:?1	R:R:W265	32.601	26.18	Yes	Yes	1	0	3
3	R:R:F7	R:R:W265	11.7342	5.01	Yes	Yes	1	5	3
4	R:R:L11	R:R:W265	10.3011	6.83	Yes	Yes	1	6	3
5	R:R:V269	R:R:W265	39.3968	9.81	No	Yes	0	6	3
6	R:R:L14	R:R:V269	39.971	4.47	No	No	0	5	6
7	R:R:I18	R:R:L14	39.4717	7.14	Yes	No	0	8	5
8	R:R:I18	R:R:N22	34.1189	4.25	Yes	Yes	0	8	9
9	R:R:N22	R:R:T52	12.5081	4.39	Yes	No	0	9	6
10	R:R:I18	R:R:L273	11.4296	5.71	Yes	No	0	8	5
11	R:R:I18	R:R:S272	11.6093	4.64	Yes	No	0	8	9
12	L:L:?1	R:R:F174	100	7.58	Yes	Yes	1	0	8
13	R:R:F174	R:R:F234	89.649	6.43	Yes	Yes	1	8	9
14	R:R:F234	R:R:V96	74.0001	5.24	Yes	No	0	9	9
15	R:R:N275	R:R:V96	43.706	4.43	Yes	No	0	9	9
16	R:R:D51	R:R:N275	45.5785	10.77	Yes	Yes	2	9	9
17	R:R:F174	R:R:S237	26.0498	3.96	Yes	No	1	8	7
18	R:R:N271	R:R:S237	55.9045	8.94	No	No	0	9	7
19	R:R:N271	R:R:N275	54.7761	9.54	No	Yes	0	9	9
20	L:L:?1	R:R:W238	20.3875	21.27	Yes	Yes	1	0	8
21	R:R:S237	R:R:W238	30.8284	8.65	No	Yes	1	7	8
22	R:R:N22	R:R:P276	47.1114	13.03	Yes	No	0	9	9
23	R:R:P276	R:R:V25	44.0056	3.53	No	No	0	9	9
24	R:R:A280	R:R:V25	39.272	5.09	No	No	0	8	9
25	R:R:A280	R:R:V286	37.6741	3.39	No	Yes	0	8	9
26	R:R:L290	R:R:V286	14.056	2.98	Yes	Yes	0	5	9
27	R:R:L47	R:R:N275	89.0947	6.87	Yes	Yes	0	9	9
28	R:R:L47	R:R:T95	61.2823	5.9	Yes	No	0	9	8
29	R:R:N46	R:R:T95	51.6852	10.24	Yes	No	3	9	8
30	R:R:N46	R:R:W130	45.5036	9.04	Yes	Yes	0	9	9
31	R:R:V49	R:R:W130	26.2396	2.45	No	Yes	0	6	9
32	R:R:L45	R:R:V49	22.994	2.98	No	No	0	6	6
33	R:R:L45	R:R:V29	13.1972	2.98	No	No	0	6	8
34	R:R:V96	R:R:Y279	39.4967	8.83	No	Yes	0	9	9
35	R:R:L47	R:R:Y279	30.7185	4.69	Yes	Yes	0	9	9
36	R:R:L32	R:R:V286	20.9467	2.98	Yes	Yes	0	7	9
37	R:R:E285	R:R:L32	10.7505	3.98	No	Yes	0	6	7
38	R:R:I99	R:R:L47	56.8133	4.28	No	Yes	0	9	9
39	R:R:F43	R:R:I99	69.0068	3.77	Yes	No	0	8	9
40	R:R:D102	R:R:F43	32.8307	9.55	No	Yes	0	9	8
41	R:R:D102	R:R:Y113	24.6817	10.34	No	Yes	0	9	9
42	R:R:R103	R:R:Y279	22.1401	5.14	No	Yes	0	9	9
43	R:R:I99	R:R:R103	30.389	5.01	No	No	0	9	9
44	R:R:F181	R:R:F234	45.4936	24.65	Yes	Yes	1	8	9
45	R:R:F181	R:R:Y185	25.3208	15.47	Yes	Yes	1	8	9
46	R:R:R103	R:R:Y185	31.123	6.17	No	Yes	0	9	9
47	R:R:F43	R:R:L98	20.5922	12.18	Yes	No	0	8	7
48	R:R:I54	R:R:S272	11.5494	9.29	No	No	0	8	9
49	R:R:D64	R:R:Q65	47.416	10.44	Yes	Yes	1	4	4
50	R:R:C155	R:R:D64	18.2504	7.78	Yes	Yes	1	9	4
51	R:R:D64	R:R:R81	20.4524	4.76	Yes	Yes	1	4	6
52	R:R:Q74	R:R:R81	13.7764	4.67	Yes	Yes	1	7	6
53	R:R:C155	R:R:Q74	13.7464	4.58	Yes	Yes	1	9	7
54	L:L:?1	R:R:F157	60.3385	28	Yes	Yes	1	0	4
55	R:R:F157	R:R:F161	19.968	6.43	Yes	Yes	1	4	4
56	R:R:F161	R:R:V160	10.356	10.49	Yes	No	1	4	5
57	L:L:?1	R:R:T86	14.2358	9.18	Yes	No	0	0	5
58	R:R:G137	R:R:T86	12.3084	3.64	No	No	0	7	5
59	R:R:G137	R:R:S87	10.2811	3.71	No	No	0	7	5
60	R:R:A91	R:R:W130	13.1972	3.89	No	Yes	0	7	9
61	R:R:C125	R:R:L98	16.4927	4.76	No	No	0	6	7
62	R:R:F181	R:R:T100	12.6979	11.67	Yes	No	1	8	8
63	R:R:F184	R:R:T100	15.564	3.89	Yes	No	0	6	8
64	R:R:F184	R:R:Y104	10.0914	19.6	Yes	No	0	6	8
65	R:R:F157	R:R:F165	15.8686	4.29	Yes	Yes	1	4	6
66	R:R:F146	R:R:F165	12.2784	7.5	Yes	Yes	1	2	6
67	R:R:F157	R:R:F158	26.3195	10.72	Yes	Yes	1	4	3
68	R:R:F158	R:R:P163	16.0234	4.33	Yes	No	1	3	3
69	R:R:H162	R:R:P163	12.9575	9.15	No	No	0	5	3
70	R:R:Q65	R:R:R262	12.1186	9.35	Yes	Yes	1	4	3
71	R:R:F158	R:R:Y257	16.1282	11.35	Yes	No	1	3	4
72	R:R:F241	R:R:L260	14.1259	10.96	Yes	No	0	6	4
73	R:R:F174	R:R:L242	14.5703	6.09	Yes	No	0	8	6
74	R:R:L242	R:R:S170	12.5181	10.51	No	No	0	6	6
75	R:R:F174	R:R:T239	11.0401	5.19	Yes	Yes	0	8	4
76	R:R:F181	R:R:I231	14.8699	3.77	Yes	No	0	8	7
77	R:R:L230	R:R:Y185	14.091	8.21	No	Yes	0	8	9
78	R:R:I231	R:R:V227	10.0015	3.07	No	No	0	7	8
79	R:R:L230	R:R:T226	11.7541	2.95	No	No	0	8	8
80	R:R:Q248	R:R:Y257	13.0823	13.53	No	No	0	3	4
81	R:R:C254	R:R:Q248	11.3647	6.1	No	No	0	4	3
82	R:R:Q74	R:R:R71	13.8064	1.17	Yes	No	0	7	6
83	R:R:A122	R:R:F43	12.3833	2.77	No	Yes	0	6	8
84	R:R:C125	R:R:V121	12.3833	1.71	No	No	0	6	6
85	R:R:F241	R:R:W238	12.7628	5.01	Yes	Yes	1	6	8
86	R:R:D51	R:R:N22	35.0177	13.46	Yes	Yes	0	9	9
87	R:R:D51	R:R:S272	11.844	8.83	Yes	No	0	9	9
88	R:R:F241	R:R:W265	11.874	4.01	Yes	Yes	1	6	3

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L61	3.98	1	Yes	No	0	5	0	1
L:L:?1	R:R:Q65	3.82	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:M82	7.45	1	Yes	No	0	5	0	1
L:L:?1	R:R:V85	4.28	1	Yes	No	0	7	0	1
L:L:?1	R:R:T86	9.18	1	Yes	No	0	5	0	1
L:L:?1	R:R:A89	4.53	1	Yes	No	0	6	0	1
L:L:?1	R:R:V93	8.56	1	Yes	No	0	7	0	1
L:L:?1	R:R:F157	28	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:L169	7.29	1	Yes	No	0	6	0	1
L:L:?1	R:R:F174	7.58	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:W238	21.27	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F241	5.83	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:W265	26.18	1	Yes	Yes	0	3	0	1
R:R:F7	R:R:L11	8.53	1	Yes	Yes	5	6	2	2
R:R:F7	R:R:Q65	11.71	1	Yes	Yes	5	4	2	1
R:R:F7	R:R:R262	19.24	1	Yes	Yes	5	3	2	2
R:R:F7	R:R:W265	5.01	1	Yes	Yes	5	3	2	1
R:R:L11	R:R:W265	6.83	1	Yes	Yes	6	3	2	1
R:R:L61	R:R:V85	4.47	1	No	No	5	7	1	1
R:R:D64	R:R:Q65	10.44	1	Yes	Yes	4	4	2	1
R:R:Q65	R:R:R262	9.35	1	Yes	Yes	4	3	1	2
R:R:A89	R:R:W238	3.89	1	No	Yes	6	8	1	1
R:R:F174	R:R:V93	3.93	1	Yes	No	8	7	1	1
R:R:F157	R:R:F158	10.72	1	Yes	Yes	4	3	1	2
R:R:F157	R:R:F161	6.43	1	Yes	Yes	4	4	1	2
R:R:F157	R:R:F165	4.29	1	Yes	Yes	4	6	1	2
R:R:F158	R:R:L260	7.31	1	Yes	No	3	4	2	2
R:R:F161	R:R:F165	4.29	1	Yes	Yes	4	6	2	2
R:R:F174	R:R:F234	6.43	1	Yes	Yes	8	9	1	2
R:R:F174	R:R:S237	3.96	1	Yes	No	8	7	1	2
R:R:F174	R:R:W238	11.02	1	Yes	Yes	8	8	1	1
R:R:F174	R:R:T239	5.19	1	Yes	Yes	8	4	1	2
R:R:F174	R:R:L242	6.09	1	Yes	No	8	6	1	2
R:R:S237	R:R:W238	8.65	1	No	Yes	7	8	2	1
R:R:F241	R:R:W238	5.01	1	Yes	Yes	6	8	1	1
R:R:G268	R:R:W238	12.67	0	No	Yes	7	8	2	1
R:R:F241	R:R:L260	10.96	1	Yes	No	6	4	1	2
R:R:F241	R:R:W265	4.01	1	Yes	Yes	6	3	1	1
R:R:V269	R:R:W265	9.81	0	No	Yes	6	3	2	1
R:R:G137	R:R:T86	3.64	0	No	No	7	5	2	1
L:L:?1	R:R:G173	3.28	1	Yes	No	0	6	0	1
R:R:I136	R:R:V132	3.07	0	No	No	6	3	1	2
R:R:F157	R:R:V166	2.62	1	Yes	Yes	4	6	1	2
R:R:F158	R:R:V166	2.62	1	Yes	Yes	3	6	2	2
R:R:F241	R:R:V166	2.62	1	Yes	Yes	6	6	1	2
L:L:?1	R:R:I136	2.05	1	Yes	No	0	6	0	1
R:R:G173	R:R:P176	2.03	0	No	No	6	5	1	2
R:R:G173	R:R:V172	1.84	0	No	No	6	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7XZ6_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.77
Number of Linked Nodes	258
Number of Links	290
Number of Hubs	39
Number of Links mediated by Hubs	148
Number of Communities	5
Number of Nodes involved in Communities	49
Number of Links involved in Communities	71

Path Summary
Number Of Nodes in MetaPath	89
Number Of Links MetaPath	88
Number of Shortest Paths	59123
Length Of Smallest Path	3
Average Path Length	11.6682
Length of Longest Path	24
Minimum Path Strength	1.17
Average Path Strength	7.56304
Maximum Path Strength	27.09
Minimum Path Correlation	0.7
Average Path Correlation	0.943727
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	6.66667
Average % Of Corr. Nodes	64.7449
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	51.1497
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • phosphatidylcholine binding • phospholipid binding • lipid binding • quaternary ammonium group binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway
Gene Ontology	Biological Process	• electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • regulation of metabolic process • establishment of protein localization • nitrogen compound transport • transport • hormone secretion • protein localization to extracellular region • peptide secretion • localization • secretion by cell • amide transport • signal release • regulation of biological quality • intracellular protein localization • secretion • regulation of hormone levels • establishment of protein localization to extracellular region • cell-cell signaling • export from cell • protein secretion • establishment of localization • peptide transport • protein transport • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • cellular anatomical structure • periplasmic space • protein-containing complex • receptor complex • cell periphery • plasma membrane • membrane • intracellular anatomical structure • cytoplasm • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of multicellular organismal process • positive regulation of cellular process • regulation of localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • regulation of secretion by cell • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • regulation of protein secretion • regulation of secretion • regulation of insulin secretion • regulation of cell communication • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • endomembrane system • trans-Golgi network
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	I7J
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	I7J
Name	propan-2-yl 4-[1-(2-fluoranyl-4-methylsulfonyl-phenyl)pyrazolo[3,4-d]pyrimidin-4-yl]oxypiperidine-1-carboxylate
Synonyms
Identifier
Formula	C21 H24 F N5 O5 S
Molecular Weight	477.509
SMILES
PubChem	11705608
Formal Charge	0
Total Atoms	57
Total Chiral Atoms	0
Total Bonds	60
Total Aromatic Bonds	16


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDV5
Sequence	>7XZ6_nogp_Chain_R M E S S F S F G V I L A V L A S L I I A T N T L V A V A V L L L I H K N D G V S L C F T L N L A V A D T L I G V A I S G L L T D Q L S S P S R P T Q K T L C S L R M A F V T S S A A A S V L T V M L I T F D R Y L A I K Q P F R Y L K I M S G F V A G A C I A G L W L V S Y L I G F L P L G I P M F Q Q T A Y K G Q C S F F A V F H P H F V L T L S C V G F F P A M L L F V F F Y C D M L K I A S M H S Q Q I R K M E H A G A M A G S D F K A L R T V S V L I G S F A L S W T P F L I T G I V Q V A C Q E C H L Y L V L E R Y L W L L G V G N S L L N P L I Y A Y W Q K E V R L Q L Y H M A L G V K K V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7WCM	A	Lipid	GPR119	GPR119	Homo sapiens	MBX-2982	-	Gs/β1/γ2	2.33	2022-12-21	doi.org/10.1038/s41467-022-34696-6
	7WCM (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	MBX-2982	-		2.33	2022-12-21	doi.org/10.1038/s41467-022-34696-6
	7WCN	A	Lipid	GPR119	GPR119	Homo sapiens	AR231453	-	Gs/β1/γ2	2.87	2022-12-21	doi.org/10.1038/s41467-022-34696-6
	7WCN (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	AR231453	-		2.87	2022-12-21	doi.org/10.1038/s41467-022-34696-6
	7XZ5	A	Lipid	GPR119	GPR119	Homo sapiens	Lysophosphatidylcholine	-	Gs/β1/γ2	3.1	2022-08-24	doi.org/10.1038/s41594-022-00816-5
	7XZ5 (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	Lysophosphatidylcholine	-		3.1	2022-08-24	doi.org/10.1038/s41594-022-00816-5
	7XZ6	A	Lipid	GPR119	GPR119	Homo sapiens	APD668	-	Gs/β1/γ2	2.8	2022-08-24	doi.org/10.1038/s41594-022-00816-5
	7XZ6 (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	APD668	-		2.8	2022-08-24	doi.org/10.1038/s41594-022-00816-5
	8VHF	A	Lipid	GPR119	GPR119	Homo sapiens	MBX-2982	-	Gs/β1/γ2	3.51	2024-10-30	doi.org/10.1016/j.str.2024.10.004
	8VHF (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	MBX-2982	-		3.51	2024-10-30	doi.org/10.1016/j.str.2024.10.004
	8ZR5	A	Lipid	GPR119	GPR119	Homo sapiens	Firuglipel	-	Gs/β1/γ2	3.31	2024-06-19	To be published
	8ZR5 (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	Firuglipel	-		3.31	2024-06-19	To be published
	8ZRK	A	Lipid	GPR119	GPR119	Homo sapiens	GSK-1292263	-	Gs/β1/γ2	2.82	2024-06-19	To be published
	8ZRK (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	GSK-1292263	-		2.82	2024-06-19	To be published

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