psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:M82	7.03	Yes	No	0	0	5
2	L:L:?1	R:R:V93	9.26	Yes	No	0	0	7
3	L:L:?1	R:R:F157	22.71	Yes	No	0	0	4
4	L:L:?1	R:R:L169	10.32	Yes	No	0	0	6
5	L:L:?1	R:R:G173	4.25	Yes	No	0	0	6
6	L:L:?1	R:R:W238	16.99	Yes	Yes	0	0	8
7	L:L:?1	R:R:F241	3.79	Yes	No	0	0	6
8	L:L:?1	R:R:W265	29.03	Yes	Yes	0	0	3
9	R:R:F7	R:R:L11	4.87	No	No	0	5	6
10	R:R:F7	R:R:R262	5.34	No	No	0	5	3
11	R:R:L11	R:R:W265	4.56	No	Yes	0	6	3
12	R:R:I18	R:R:N22	4.25	Yes	Yes	0	8	9
13	R:R:G55	R:R:I18	3.53	No	Yes	0	8	8
14	R:R:I18	R:R:S272	4.64	Yes	No	0	8	9
15	R:R:I18	R:R:L273	4.28	Yes	No	0	8	5
16	R:R:I19	R:R:T52	4.56	No	No	0	6	6
17	R:R:N22	R:R:T21	4.39	Yes	No	0	9	8
18	R:R:D51	R:R:N22	9.42	Yes	Yes	0	9	9
19	R:R:N22	R:R:P276	4.89	Yes	No	0	9	9
20	R:R:L41	R:R:V29	4.47	Yes	No	0	9	8
21	R:R:L45	R:R:V29	4.47	No	No	0	6	8
22	R:R:L31	R:R:Q289	6.65	No	Yes	0	5	7
23	R:R:L32	R:R:Q289	10.65	Yes	Yes	0	7	7
24	R:R:I33	R:R:L41	4.28	No	Yes	0	7	9
25	R:R:K35	R:R:N36	8.39	No	No	0	6	9
26	R:R:D37	R:R:G38	5.03	No	No	0	8	7
27	R:R:A122	R:R:C42	3.61	No	No	0	6	4
28	R:R:C42	R:R:I126	4.91	No	No	0	4	7
29	R:R:F43	R:R:L98	7.31	Yes	No	0	8	7
30	R:R:F43	R:R:I99	3.77	Yes	No	0	8	9
31	R:R:D102	R:R:F43	8.36	No	Yes	0	9	8
32	R:R:F43	R:R:I126	3.77	Yes	No	0	8	7
33	R:R:N46	R:R:T95	8.77	No	No	0	9	8
34	R:R:I126	R:R:N46	12.74	No	No	0	7	9
35	R:R:N46	R:R:W130	9.04	No	Yes	0	9	9
36	R:R:D51	R:R:L47	5.43	Yes	No	0	9	9
37	R:R:L47	R:R:T95	8.84	No	No	0	9	8
38	R:R:D51	R:R:S92	5.89	Yes	No	0	9	9
39	R:R:D51	R:R:S272	8.83	Yes	No	0	9	9
40	R:R:D51	R:R:N275	5.39	Yes	No	0	9	9
41	R:R:G55	R:R:I54	3.53	No	No	0	8	8
42	R:R:I54	R:R:S88	4.64	No	No	0	8	6
43	R:R:I54	R:R:S272	4.64	No	No	0	8	9
44	R:R:A57	R:R:F84	5.55	No	No	0	4	3
45	R:R:I58	R:R:V269	4.61	No	No	0	7	6
46	R:R:L61	R:R:R81	3.64	No	Yes	0	5	6
47	R:R:L61	R:R:M82	4.24	No	No	0	5	5
48	R:R:L61	R:R:V85	4.47	No	No	0	5	7
49	R:R:D64	R:R:T63	4.34	No	No	0	4	5
50	R:R:R81	R:R:T63	5.17	Yes	No	0	6	5
51	R:R:D64	R:R:Q65	11.75	No	No	0	4	4
52	R:R:L77	R:R:Q74	5.32	No	No	0	4	7
53	R:R:K75	R:R:Y151	15.53	No	Yes	0	3	4
54	R:R:L77	R:R:R81	10.93	No	Yes	0	4	6
55	R:R:C78	R:R:Y151	4.03	No	Yes	3	9	4
56	R:R:C155	R:R:C78	7.28	No	No	3	9	9
57	R:R:L141	R:R:S79	4.5	No	No	0	6	4
58	R:R:A83	R:R:F138	8.32	No	No	0	6	4
59	R:R:F84	R:R:S88	3.96	No	No	0	3	6
60	R:R:F84	R:R:Y134	7.22	No	Yes	0	3	4
61	R:R:F157	R:R:T86	3.89	No	No	0	4	5
62	R:R:S87	R:R:Y134	16.53	No	Yes	0	5	4
63	R:R:G137	R:R:S87	3.71	No	No	0	7	5
64	R:R:A91	R:R:W130	3.89	No	Yes	0	7	9
65	R:R:L129	R:R:T95	5.9	No	No	0	6	8
66	R:R:F234	R:R:V96	3.93	Yes	No	0	9	9
67	R:R:V96	R:R:Y279	5.05	No	Yes	0	9	9
68	R:R:A177	R:R:M97	4.83	No	No	0	8	7
69	R:R:F234	R:R:M97	3.73	Yes	No	0	9	7
70	R:R:I99	R:R:Y279	4.84	No	Yes	0	9	9
71	R:R:F181	R:R:T100	7.78	Yes	No	1	8	8
72	R:R:F184	R:R:T100	3.89	Yes	No	0	6	8
73	R:R:T100	R:R:Y185	13.73	No	Yes	1	8	9
74	R:R:F101	R:R:F184	7.5	No	Yes	0	5	6
75	R:R:D102	R:R:Y113	9.2	No	Yes	0	9	9
76	R:R:R103	R:R:Y185	4.12	No	Yes	0	9	9
77	R:R:R103	R:R:Y279	5.14	No	Yes	0	9	9
78	R:R:K108	R:R:Y104	13.14	No	Yes	4	6	8
79	R:R:F184	R:R:Y104	20.63	Yes	Yes	0	6	8
80	R:R:D187	R:R:Y104	8.05	No	Yes	4	5	8
81	R:R:M188	R:R:Y104	3.59	No	Yes	0	9	8
82	R:R:A106	R:R:Y113	8.01	No	Yes	0	9	9
83	R:R:K108	R:R:Q109	4.07	No	No	0	6	5
84	R:R:D187	R:R:K108	6.91	No	No	4	5	6
85	R:R:Q109	R:R:R112	7.01	No	No	0	5	5
86	R:R:M117	R:R:Y113	16.76	No	Yes	0	7	9
87	R:R:G119	R:R:S118	3.71	No	No	0	1	8
88	R:R:L129	R:R:W130	5.69	No	Yes	0	6	9
89	R:R:W130	R:R:Y134	3.86	Yes	Yes	0	9	4
90	R:R:L135	R:R:L139	4.15	No	No	0	3	4
91	R:R:F146	R:R:P140	4.33	Yes	No	2	2	5
92	R:R:F161	R:R:P140	14.45	No	No	2	4	5
93	R:R:F165	R:R:P140	8.67	Yes	No	2	6	5
94	R:R:F146	R:R:I143	8.79	Yes	No	0	2	4
95	R:R:F146	R:R:M145	11.2	Yes	No	0	2	3
96	R:R:F146	R:R:F165	5.36	Yes	Yes	2	2	6
97	R:R:F146	R:R:T168	6.49	Yes	No	0	2	4
98	R:R:H162	R:R:Q148	3.71	No	No	0	5	4
99	R:R:G153	R:R:Y151	5.79	No	Yes	0	3	4
100	R:R:C155	R:R:Y151	4.03	No	Yes	3	9	4
101	R:R:G153	R:R:K152	5.23	No	No	0	3	1
102	R:R:K152	R:R:Q154	13.56	No	No	0	1	2
103	R:R:E261	R:R:S156	8.62	No	No	0	4	4
104	R:R:F157	R:R:F158	7.5	No	Yes	0	4	3
105	R:R:F158	R:R:P163	7.22	Yes	No	0	3	3
106	R:R:F158	R:R:Y257	11.35	Yes	No	0	3	4
107	R:R:F158	R:R:L260	7.31	Yes	Yes	0	3	4
108	R:R:E261	R:R:F158	8.16	No	Yes	0	4	3
109	R:R:F161	R:R:V160	5.24	No	No	0	4	5
110	R:R:F161	R:R:F165	6.43	No	Yes	2	4	6
111	R:R:H162	R:R:P163	9.15	No	No	0	5	3
112	R:R:H162	R:R:H164	9.55	No	No	0	5	2
113	R:R:F165	R:R:L169	4.87	Yes	No	0	6	6
114	R:R:L167	R:R:V249	5.96	No	No	0	5	4
115	R:R:F175	R:R:S170	7.93	No	No	0	5	6
116	R:R:L242	R:R:S170	6.01	No	No	0	6	6
117	R:R:F174	R:R:M178	3.73	Yes	No	1	8	5
118	R:R:F174	R:R:F234	4.29	Yes	Yes	1	8	9
119	R:R:F174	R:R:W238	10.02	Yes	Yes	0	8	8
120	R:R:F174	R:R:T239	5.19	Yes	No	0	8	4
121	R:R:F174	R:R:L242	4.87	Yes	No	0	8	6
122	R:R:F234	R:R:M178	7.46	Yes	No	1	9	5
123	R:R:F181	R:R:Y185	13.41	Yes	Yes	1	8	9
124	R:R:F181	R:R:I231	3.77	Yes	No	0	8	7
125	R:R:F181	R:R:F234	23.58	Yes	Yes	1	8	9
126	R:R:F183	R:R:F184	5.36	No	Yes	0	3	6
127	R:R:M188	R:R:Y185	4.79	No	Yes	0	9	9
128	R:R:V227	R:R:Y185	3.79	No	Yes	0	8	9
129	R:R:L230	R:R:Y185	5.86	No	Yes	0	8	9
130	R:R:H195	R:R:M194	6.57	No	No	0	8	4
131	R:R:H195	R:R:Q198	4.95	No	No	0	8	5
132	R:R:R200	R:R:S196	3.95	No	No	0	4	5
133	R:R:Q197	R:R:R200	4.67	No	No	0	5	4
134	R:R:H204	R:R:M208	5.25	No	No	0	4	2
135	R:R:T226	R:R:W282	4.85	No	No	0	8	7
136	R:R:S237	R:R:W238	4.94	No	Yes	0	7	8
137	R:R:N271	R:R:S237	5.96	No	No	0	9	7
138	R:R:G268	R:R:W238	11.26	No	Yes	0	7	8
139	R:R:F241	R:R:L260	6.09	No	Yes	0	6	4
140	R:R:L256	R:R:T244	5.9	Yes	No	0	5	4
141	R:R:L260	R:R:T244	7.37	Yes	No	0	4	4
142	R:R:L264	R:R:T244	4.42	No	No	0	4	4
143	R:R:L256	R:R:Q248	5.32	Yes	No	0	5	3
144	R:R:Q248	R:R:Y257	7.89	No	No	0	3	4
145	R:R:C251	R:R:C254	5.46	No	No	0	4	4
146	R:R:V259	R:R:Y263	5.05	No	No	0	1	4
147	R:R:R262	R:R:Y263	10.29	No	No	0	3	4
148	R:R:L266	R:R:W265	9.11	No	Yes	0	5	3
149	R:R:V269	R:R:W265	4.9	No	Yes	0	6	3
150	R:R:N271	R:R:N275	9.54	No	No	0	9	9
151	R:R:I278	R:R:Y279	6.04	Yes	Yes	0	8	9
152	R:R:Q283	R:R:V286	5.73	No	No	0	8	9
153	R:R:R287	R:R:Y291	7.2	No	No	0	8	2
154	R:R:H292	R:R:L288	10.29	No	No	0	5	4
155	R:R:M293	R:R:Q289	4.08	Yes	Yes	0	5	7
156	R:R:L105	R:R:Y113	3.52	No	Yes	0	5	9
157	R:R:P240	R:R:T239	3.5	No	No	0	9	4
158	R:R:A91	R:R:S133	3.42	No	No	0	7	8
159	R:R:A159	R:R:S156	3.42	No	No	0	4	4
160	R:R:A280	R:R:V25	3.39	No	No	0	8	9
161	R:R:I143	R:R:P144	3.39	No	No	0	4	2
162	R:R:L267	R:R:P240	3.28	No	No	0	7	9
163	R:R:S79	R:R:V160	3.23	No	No	0	4	5
164	R:R:A28	R:R:M293	3.22	No	Yes	0	7	5
165	R:R:A235	R:R:M178	3.22	No	No	0	6	5
166	R:R:C125	R:R:L98	3.17	No	No	0	6	7
167	R:R:C254	R:R:L256	3.17	No	Yes	0	4	5
168	R:R:A12	R:R:L62	3.15	No	No	0	4	6
169	R:R:A28	R:R:L290	3.15	No	No	0	7	5
170	R:R:T23	R:R:T52	3.14	No	No	0	5	6
171	R:R:I246	R:R:S170	3.1	No	No	0	5	6
172	R:R:I278	R:R:S233	3.1	Yes	No	0	8	7
173	R:R:F138	R:R:Y134	3.09	No	Yes	0	4	4
174	R:R:R287	R:R:Y281	3.09	No	No	0	8	5
175	R:R:I19	R:R:V56	3.07	No	No	0	6	4
176	R:R:M293	R:R:V27	3.04	Yes	No	0	5	5
177	R:R:M117	R:R:V39	3.04	No	No	0	7	5
178	R:R:I243	R:R:T239	3.04	No	No	0	5	4
179	R:R:L94	R:R:S133	3	No	No	0	5	8
180	R:R:R225	R:R:W282	3	No	No	0	6	7
181	R:R:L32	R:R:V286	2.98	Yes	No	0	7	9
182	R:R:L256	R:R:V247	2.98	Yes	No	0	5	4
183	R:R:L41	R:R:T44	2.95	Yes	No	0	9	7
184	R:R:L80	R:R:T76	2.95	No	No	0	5	2
185	L:L:?1	R:R:A89	2.94	Yes	No	0	0	6
186	R:R:Q197	R:R:S193	2.89	No	No	0	5	6
187	R:R:I143	R:R:L139	2.85	No	No	0	4	4
188	R:R:I246	R:R:L167	2.85	No	No	0	5	5
189	R:R:L24	R:R:M293	2.83	No	Yes	0	8	5
190	R:R:C78	R:R:R81	2.79	No	Yes	0	9	6
191	R:R:L14	R:R:L273	2.77	No	No	0	5	5
192	R:R:L17	R:R:L273	2.77	No	No	0	4	5
193	R:R:L30	R:R:L45	2.77	No	No	0	3	6
194	R:R:L32	R:R:L41	2.77	Yes	Yes	0	7	9
195	R:R:H195	R:R:I191	2.65	No	No	0	8	6
196	R:R:F241	R:R:V166	2.62	No	No	0	6	6
197	R:R:A50	R:R:W130	2.59	No	Yes	0	8	9
198	R:R:I116	R:R:R112	2.51	No	No	0	5	5
199	R:R:F184	R:R:L180	2.44	Yes	No	0	6	5
200	R:R:L258	R:R:R262	2.43	No	No	0	1	3
201	R:R:D220	R:R:F221	2.39	No	No	0	7	4
202	R:R:D220	R:R:R200	2.38	No	No	0	7	4
203	R:R:I278	R:R:W282	2.35	Yes	No	0	8	7
204	R:R:L53	R:R:W130	2.28	No	Yes	0	8	9
205	R:R:G173	R:R:P176	2.03	No	No	0	6	5
206	R:R:A122	R:R:G119	1.95	No	No	0	6	1
207	R:R:A122	R:R:G123	1.95	No	No	0	6	1
208	R:R:A127	R:R:G128	1.95	No	No	0	3	3
209	R:R:A205	R:R:G206	1.95	No	No	0	4	2
210	R:R:A209	R:R:G206	1.95	No	No	0	3	2
211	R:R:A209	R:R:G210	1.95	No	No	0	3	1
212	R:R:G60	R:R:S59	1.86	No	No	0	7	7
213	R:R:A26	R:R:A48	1.79	No	No	0	7	9
214	R:R:A192	R:R:A223	1.79	No	No	0	8	8
215	R:R:P276	R:R:V25	1.77	No	No	0	9	9
216	R:R:G55	R:R:I19	1.76	No	No	0	8	6
217	R:R:G137	R:R:I136	1.76	No	No	0	7	6
218	R:R:G8	R:R:L11	1.71	No	No	0	4	6
219	R:R:G8	R:R:L62	1.71	No	No	0	4	6
220	R:R:A15	R:R:S59	1.71	No	No	0	6	7
221	R:R:G38	R:R:L41	1.71	No	Yes	0	7	9
222	R:R:A90	R:R:S133	1.71	No	No	0	7	8
223	R:R:C125	R:R:V121	1.71	No	No	0	6	6
224	R:R:G128	R:R:L131	1.71	No	No	0	3	3
225	R:R:C171	R:R:V172	1.71	No	No	0	4	4
226	R:R:G245	R:R:L260	1.71	No	Yes	0	6	4
227	R:R:A48	R:R:V25	1.7	No	No	0	9	9
228	R:R:A280	R:R:V286	1.7	No	No	0	8	9
229	R:R:A150	R:R:T149	1.68	No	No	0	2	1
230	R:R:S228	R:R:V229	1.62	No	No	0	7	7
231	R:R:C171	R:R:L167	1.59	No	No	0	4	5
232	R:R:P110	R:R:Q109	1.58	No	No	0	8	5
233	R:R:P144	R:R:Q147	1.58	No	No	0	2	1
234	R:R:A223	R:R:L189	1.58	No	No	0	8	7
235	R:R:I136	R:R:V132	1.54	No	No	0	6	3
236	R:R:I231	R:R:V182	1.54	No	No	0	7	5
237	R:R:I278	R:R:V229	1.54	Yes	No	0	8	7
238	R:R:L62	R:R:S59	1.5	No	No	0	6	7
239	R:R:L17	R:R:V13	1.49	No	No	0	4	4
240	R:R:L45	R:R:V49	1.49	No	No	0	6	6
241	R:R:L189	R:R:V227	1.49	No	No	0	7	8
242	R:R:D102	R:R:S40	1.47	No	No	0	9	8
243	R:R:I107	R:R:I191	1.47	No	No	0	8	6
244	R:R:I107	R:R:M188	1.46	No	No	0	8	9
245	R:R:L141	R:R:L80	1.38	No	No	0	6	5
246	R:R:L189	R:R:L224	1.38	No	No	0	7	7
247	R:R:E203	R:R:I199	1.37	No	No	0	3	8
248	R:R:L274	R:R:N271	1.37	No	No	0	5	9
249	R:R:K35	R:R:Q289	1.36	No	Yes	0	6	7
250	R:R:E285	R:R:L32	1.33	No	Yes	0	6	7
251	R:R:F120	R:R:V121	1.31	No	No	0	3	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	11.8133	9	0	0
2	R:R:I18	4.175	4	0	8
3	R:R:N22	5.7375	4	0	9
4	R:R:L32	4.4325	4	0	7
5	R:R:L41	3.236	5	0	9
6	R:R:F43	5.8025	4	0	8
7	R:R:D51	6.992	5	0	9
8	R:R:R81	5.6325	4	0	6
9	R:R:Y104	11.3525	4	4	8
10	R:R:Y113	9.3725	4	0	9
11	R:R:W130	4.55833	6	0	9
12	R:R:Y134	7.675	4	0	4
13	R:R:F146	7.234	5	2	2
14	R:R:Y151	7.345	4	3	4
15	R:R:F158	8.308	5	0	3
16	R:R:F165	6.3325	4	2	6
17	R:R:F174	5.62	5	1	8
18	R:R:F181	12.135	4	1	8
19	R:R:F184	7.964	5	0	6
20	R:R:Y185	7.61667	6	1	9
21	R:R:F234	8.598	5	1	9
22	R:R:W238	10.8025	4	0	8
23	R:R:L256	4.3425	4	0	5
24	R:R:L260	5.62	4	0	4
25	R:R:W265	11.9	4	0	3
26	R:R:I278	3.2575	4	0	8
27	R:R:Y279	5.2675	4	0	9
28	R:R:Q289	5.685	4	0	7
29	R:R:M293	3.2925	4	0	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W265	27.5629	29.03	Yes	Yes	0	0	3
2	R:R:L11	R:R:W265	21.0677	4.56	No	Yes	0	6	3
3	L:L:?1	R:R:W238	100	16.99	Yes	Yes	0	0	8
4	R:R:S237	R:R:W238	80.9813	4.94	No	Yes	0	7	8
5	R:R:N271	R:R:S237	80.6607	5.96	No	No	0	9	7
6	R:R:N271	R:R:N275	80.3122	9.54	No	No	0	9	9
7	R:R:D51	R:R:N275	80.131	5.39	Yes	No	0	9	9
8	R:R:D51	R:R:N22	54.7704	9.42	Yes	Yes	0	9	9
9	R:R:I18	R:R:N22	18.9978	4.25	Yes	Yes	0	8	9
10	R:R:D51	R:R:S272	29.4167	8.83	Yes	No	0	9	9
11	R:R:I18	R:R:S272	15.4506	4.64	Yes	No	0	8	9
12	R:R:G55	R:R:I18	15.9105	3.53	No	Yes	0	8	8
13	R:R:I54	R:R:S272	18.6076	4.64	No	No	0	8	9
14	R:R:G55	R:R:I54	10.4746	3.53	No	No	0	8	8
15	R:R:I18	R:R:L273	12.2587	4.28	Yes	No	0	8	5
16	R:R:G55	R:R:I19	16.5796	1.76	No	No	0	8	6
17	R:R:N22	R:R:P276	46.0938	4.89	Yes	No	0	9	9
18	R:R:P276	R:R:V25	44.5676	1.77	No	No	0	9	9
19	R:R:A280	R:R:V25	39.9052	3.39	No	No	0	8	9
20	R:R:A280	R:R:V286	38.3232	1.7	No	No	0	8	9
21	R:R:L32	R:R:V286	35.1174	2.98	Yes	No	0	7	9
22	R:R:L32	R:R:L41	16.489	2.77	Yes	Yes	0	7	9
23	R:R:L32	R:R:Q289	16.489	10.65	Yes	Yes	0	7	7
24	R:R:F174	R:R:W238	69.5519	10.02	Yes	Yes	0	8	8
25	R:R:F174	R:R:F234	61.8092	4.29	Yes	Yes	1	8	9
26	R:R:F234	R:R:V96	23.4093	3.93	Yes	No	0	9	9
27	R:R:V96	R:R:Y279	22.5521	5.05	No	Yes	0	9	9
28	R:R:I99	R:R:Y279	30.4969	4.84	No	Yes	0	9	9
29	R:R:F43	R:R:I99	30.253	3.77	Yes	No	0	8	9
30	R:R:F43	R:R:I126	26.5733	3.77	Yes	No	0	8	7
31	R:R:D102	R:R:F43	11.6524	8.36	No	Yes	0	9	8
32	R:R:D51	R:R:L47	39.1386	5.43	Yes	No	0	9	9
33	R:R:L47	R:R:T95	38.5811	8.84	No	No	0	9	8
34	R:R:N46	R:R:T95	25.7649	8.77	No	No	0	9	8
35	R:R:N46	R:R:W130	22.4057	9.04	No	Yes	0	9	9
36	R:R:L129	R:R:T95	13.3389	5.9	No	No	0	6	8
37	R:R:L129	R:R:W130	12.405	5.69	No	Yes	0	6	9
38	R:R:I54	R:R:S88	15.5969	4.64	No	No	0	8	6
39	R:R:F84	R:R:S88	14.6073	3.96	No	No	0	3	6
40	L:L:?1	R:R:M82	27.6883	7.03	Yes	No	0	0	5
41	R:R:L61	R:R:M82	26.1273	4.24	No	No	0	5	5
42	R:R:L61	R:R:R81	22.8239	3.64	No	Yes	0	5	6
43	R:R:C78	R:R:R81	12.5793	2.79	No	Yes	0	9	6
44	L:L:?1	R:R:L169	29.3052	10.32	Yes	No	0	0	6
45	R:R:F165	R:R:L169	27.758	4.87	Yes	No	0	6	6
46	R:R:F161	R:R:F165	10.7812	6.43	No	Yes	2	4	6
47	R:R:W130	R:R:Y134	19.0815	3.86	Yes	Yes	0	9	4
48	R:R:F84	R:R:Y134	12.9347	7.22	No	Yes	0	3	4
49	R:R:S87	R:R:Y134	14.2379	16.53	No	Yes	0	5	4
50	R:R:G137	R:R:S87	10.6976	3.71	No	No	0	7	5
51	R:R:A91	R:R:W130	10.0843	3.89	No	Yes	0	7	9
52	R:R:F181	R:R:F234	40.5673	23.58	Yes	Yes	1	8	9
53	R:R:F181	R:R:T100	13.6107	7.78	Yes	No	1	8	8
54	R:R:F184	R:R:T100	14.1334	3.89	Yes	No	0	6	8
55	R:R:F181	R:R:Y185	24.2735	13.41	Yes	Yes	1	8	9
56	R:R:R103	R:R:Y279	11.1297	5.14	No	Yes	0	9	9
57	R:R:R103	R:R:Y185	10.5443	4.12	No	Yes	0	9	9
58	R:R:K108	R:R:Y104	13.7222	13.14	No	Yes	4	6	8
59	R:R:M188	R:R:Y185	19.9665	4.79	No	Yes	0	9	9
60	R:R:M188	R:R:Y104	11.1854	3.59	No	Yes	0	9	8
61	R:R:K108	R:R:Q109	11.0321	4.07	No	No	0	6	5
62	R:R:F146	R:R:F165	14.2658	5.36	Yes	Yes	2	2	6
63	L:L:?1	R:R:F157	20.2732	22.71	Yes	No	0	0	4
64	R:R:F157	R:R:F158	17.2277	7.5	No	Yes	0	4	3
65	L:L:?1	R:R:F241	16.8374	3.79	Yes	No	0	0	6
66	R:R:F241	R:R:L260	13.7989	6.09	No	Yes	0	6	4
67	R:R:F174	R:R:L242	13.1507	4.87	Yes	No	0	8	6
68	R:R:L242	R:R:S170	11.5548	6.01	No	No	0	6	6
69	R:R:I278	R:R:Y279	11.5688	6.04	Yes	Yes	0	8	9
70	R:R:L260	R:R:T244	10.7812	7.37	Yes	No	0	4	4
71	R:R:G8	R:R:L11	10.8231	1.71	No	No	0	4	6
72	R:R:I126	R:R:N46	24.0644	12.74	No	No	0	7	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:M82	7.03	0	Yes	No	0	5	0	1
L:L:?1	R:R:V93	9.26	0	Yes	No	0	7	0	1
L:L:?1	R:R:F157	22.71	0	Yes	No	0	4	0	1
L:L:?1	R:R:L169	10.32	0	Yes	No	0	6	0	1
L:L:?1	R:R:G173	4.25	0	Yes	No	0	6	0	1
L:L:?1	R:R:W238	16.99	0	Yes	Yes	0	8	0	1
L:L:?1	R:R:F241	3.79	0	Yes	No	0	6	0	1
L:L:?1	R:R:W265	29.03	0	Yes	Yes	0	3	0	1
R:R:L11	R:R:W265	4.56	0	No	Yes	6	3	2	1
R:R:L61	R:R:M82	4.24	0	No	No	5	5	2	1
R:R:F157	R:R:T86	3.89	0	No	No	4	5	1	2
R:R:F157	R:R:F158	7.5	0	No	Yes	4	3	1	2
R:R:F158	R:R:L260	7.31	0	Yes	Yes	3	4	2	2
R:R:F165	R:R:L169	4.87	2	Yes	No	6	6	2	1
R:R:F174	R:R:W238	10.02	1	Yes	Yes	8	8	2	1
R:R:S237	R:R:W238	4.94	0	No	Yes	7	8	2	1
R:R:G268	R:R:W238	11.26	0	No	Yes	7	8	2	1
R:R:F241	R:R:L260	6.09	0	No	Yes	6	4	1	2
R:R:L266	R:R:W265	9.11	0	No	Yes	5	3	2	1
R:R:V269	R:R:W265	4.9	0	No	Yes	6	3	2	1
L:L:?1	R:R:A89	2.94	0	Yes	No	0	6	0	1
R:R:F241	R:R:V166	2.62	0	No	No	6	6	1	2
R:R:G173	R:R:P176	2.03	0	No	No	6	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8ZRK_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.53
Number of Linked Nodes	245
Number of Links	251
Number of Hubs	29
Number of Links mediated by Hubs	116
Number of Communities	4
Number of Nodes involved in Communities	16
Number of Links involved in Communities	18

Path Summary
Number Of Nodes in MetaPath	73
Number Of Links MetaPath	72
Number of Shortest Paths	31544
Length Of Smallest Path	3
Average Path Length	12.2386
Length of Longest Path	25
Minimum Path Strength	1.435
Average Path Strength	6.92161
Maximum Path Strength	23.01
Minimum Path Correlation	0.7
Average Path Correlation	0.945754
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	7.69231
Average % Of Corr. Nodes	65.6363
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.3278
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • establishment of protein localization • nitrogen compound transport • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • secretion by cell • signal release • regulation of biological quality • intracellular protein localization • secretion • regulation of hormone levels • establishment of protein localization to extracellular region • cell-cell signaling • export from cell • protein secretion • establishment of localization • peptide transport • protein transport • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • protein-containing complex • receptor complex • cell periphery • cellular anatomical structure • plasma membrane • membrane • intracellular anatomical structure • cytoplasm • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • cellular homeostasis • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • intracellular chemical homeostasis • intracellular glucose homeostasis • neuromuscular process • regulation of system process • skeletal muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • striated muscle contraction • multicellular organismal movement • musculoskeletal movement • regulation of striated muscle contraction • regulation of muscle contraction • regulation of skeletal muscle contraction • regulation of multicellular organismal process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • positive regulation of biological process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • positive regulation of cell communication • regulation of localization • positive regulation of establishment of protein localization • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • regulation of peptide hormone secretion • positive regulation of peptide hormone secretion • regulation of protein secretion • regulation of secretion • cellular response to carbohydrate stimulus • response to glucose • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • positive regulation of secretion by cell • positive regulation of protein transport • regulation of secretion by cell • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • cellular response to hexose stimulus • cellular response to monosaccharide stimulus • positive regulation of cellular process • positive regulation of peptide secretion • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • response to hexose • positive regulation of transport • regulation of cellular localization • regulation of insulin secretion • regulation of insulin secretion involved in cellular response to glucose stimulus • regulation of cell communication • positive regulation of signaling • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • serotonin receptor signaling pathway • adenylate cyclase-activating serotonin receptor signaling pathway • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • cell surface receptor signaling pathway • bile acid signaling pathway • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • endomembrane system • trans-Golgi network
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDV5
Sequence	>8ZRK_nogp_Chain_R S F G V I L A V L A S L I I A T N T L V A V A V L L L I H K N D G V S L C F T L N L A V A D T L I G V A I S G L L T D Q Q K T L C S L R M A F V T S S A A A S V L T V M L I T F D R Y L A I K Q P F R Y L K I M S G F V A G A C I A G L W L V S Y L I G F L P L G I P M F Q Q T A Y K G Q C S F F A V F H P H F V L T L S C V G F F P A M L L F V F F Y C D M L K I A S M H S Q Q I R K M E H A G A M A G S D F K A L R T V S V L I G S F A L S W T P F L I T G I V Q V A C Q E C H L Y L V L E R Y L W L L G V G N S L L N P L I Y A Y W Q K E V R L Q L Y H M Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7XZ5	A	Lipid	GPR119	GPR119	Homo sapiens	Lysophosphatidylcholine	-	Gs/β1/γ2	3.1	2022-08-24	doi.org/10.1038/s41594-022-00816-5
	7XZ5 (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	Lysophosphatidylcholine	-		3.1	2022-08-24	doi.org/10.1038/s41594-022-00816-5
	7XZ6	A	Lipid	GPR119	GPR119	Homo sapiens	APD668	-	Gs/β1/γ2	2.8	2022-08-24	doi.org/10.1038/s41594-022-00816-5
	7XZ6 (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	APD668	-		2.8	2022-08-24	doi.org/10.1038/s41594-022-00816-5
	7WCM	A	Lipid	GPR119	GPR119	Homo sapiens	MBX-2982	-	Gs/β1/γ2	2.33	2022-12-21	doi.org/10.1038/s41467-022-34696-6
	7WCM (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	MBX-2982	-		2.33	2022-12-21	doi.org/10.1038/s41467-022-34696-6
	7WCN	A	Lipid	GPR119	GPR119	Homo sapiens	AR231453	-	Gs/β1/γ2	2.87	2022-12-21	doi.org/10.1038/s41467-022-34696-6
	7WCN (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	AR231453	-		2.87	2022-12-21	doi.org/10.1038/s41467-022-34696-6
	8ZR5	A	Lipid	GPR119	GPR119	Homo sapiens	Firuglipel	-	Gs/β1/γ2	3.31	2024-06-19	To be published
	8ZR5 (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	Firuglipel	-		3.31	2024-06-19	To be published
	8ZRK	A	Lipid	GPR119	GPR119	Homo sapiens	GSK1292263	-	Gs/β1/γ2	2.82	2024-06-19	To be published
	8ZRK (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	GSK1292263	-		2.82	2024-06-19	To be published
	8VHF	A	Lipid	GPR119	GPR119	Homo sapiens	MBX-2982	-	Gs/β1/γ2	3.51	2024-10-30	doi.org/10.1016/j.str.2024.10.004
	8VHF (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	MBX-2982	-		3.51	2024-10-30	doi.org/10.1016/j.str.2024.10.004
	9L79	A	Lipid	GPR119	GPR119	Homo sapiens	AR231453	-	chim(NtGi1-Gs)/β1/γ2	2.98	2025-12-31	To be published
	9L79 (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	AR231453	-		2.98	2025-12-31	To be published
	9L80	A	Lipid	GPR119	GPR119	Homo sapiens	-	Atazanavir	chim(NtGi1-Gs)/β1/γ2	3.33	2025-12-31	To be published
	9L80 (No Gprot)	A	Lipid	GPR119	GPR119	Homo sapiens	-	Atazanavir		3.33	2025-12-31	To be published

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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Data downloads are temporarily suspended for technical reasons.
We apologize for the inconvenience.