psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	A:A:D11	A:A:T9	8.67	No	No	19	2	6
2	A:A:Q12	A:A:T9	5.67	No	No	19	2	6
3	A:A:E10	A:A:R13	6.98	No	No	0	2	4
4	A:A:D11	A:A:Q12	9.14	No	No	19	2	2
5	A:A:E15	A:A:Q12	10.19	No	No	0	6	2
6	A:A:K17	A:A:R13	8.66	No	No	0	4	4
7	A:A:Q19	B:B:D83	10.44	No	No	15	4	8
8	A:A:Q19	B:B:T86	5.67	No	No	15	4	6
9	A:A:Q19	B:B:N88	13.2	No	No	15	4	7
10	A:A:K24	A:A:R20	8.66	No	No	0	4	3
11	A:A:N23	B:B:N88	6.81	No	No	0	7	7
12	A:A:N23	B:B:K89	5.6	No	Yes	0	7	9
13	A:A:I26	B:B:K89	5.82	Yes	Yes	0	9	9
14	A:A:E27	A:A:Q31	3.82	No	No	0	6	4
15	A:A:E27	B:B:K89	6.75	No	Yes	0	6	9
16	A:A:K32	A:A:Q29	6.78	No	No	0	4	4
17	A:A:D33	A:A:Q29	9.14	No	No	0	5	4
18	A:A:D33	B:B:K78	8.3	No	No	0	5	8
19	A:A:K34	A:A:R38	6.19	No	No	20	4	4
20	A:A:K34	B:B:L55	5.64	No	Yes	20	4	6
21	A:A:Q35	R:R:R125	16.35	No	No	0	3	8
22	A:A:R42	A:A:Y37	19.55	No	No	0	9	4
23	A:A:Y37	B:B:L55	14.07	No	Yes	0	4	6
24	A:A:Y37	B:B:A56	5.34	No	No	0	4	7
25	A:A:R38	B:B:L55	3.64	No	Yes	20	4	6
26	A:A:N218	A:A:T40	5.85	No	No	0	4	7
27	A:A:H41	A:A:T242	6.85	No	No	21	6	8
28	A:A:H41	A:A:I383	7.95	No	No	21	6	8
29	A:A:D240	A:A:R42	5.96	No	No	0	6	9
30	A:A:I245	A:A:L43	7.14	Yes	No	0	7	7
31	A:A:L43	A:A:V379	4.47	No	No	0	7	8
32	A:A:L44	A:A:L46	9.69	No	No	0	9	8
33	A:A:F222	A:A:L44	8.53	Yes	No	1	7	9
34	A:A:F238	A:A:L44	10.96	Yes	No	1	9	9
35	A:A:I245	A:A:L45	5.71	Yes	No	0	7	8
36	A:A:I244	A:A:L46	4.28	No	No	0	8	8
37	A:A:G47	A:A:S51	3.71	No	No	0	9	9
38	A:A:D49	A:A:N50	4.04	No	Yes	0	8	9
39	A:A:D249	A:A:N50	10.77	No	Yes	16	8	9
40	A:A:D252	A:A:N50	5.39	Yes	Yes	16	8	9
41	A:A:N50	A:A:R265	16.87	Yes	Yes	16	9	9
42	A:A:S51	A:A:V247	6.46	No	No	0	9	7
43	A:A:G52	A:A:T55	3.64	No	No	0	9	9
44	A:A:D223	A:A:K53	11.06	No	No	0	9	9
45	A:A:F208	A:A:V57	13.11	No	No	0	5	7
46	A:A:D368	A:A:Q59	14.36	No	No	0	9	9
47	A:A:H64	A:A:M60	7.88	No	No	0	8	9
48	A:A:F208	A:A:R61	11.76	No	No	0	5	8
49	A:A:H64	A:A:L63	10.29	No	No	0	8	9
50	A:A:F212	A:A:H64	11.31	Yes	No	0	9	8
51	A:A:G66	A:A:T210	3.64	No	No	0	3	7
52	A:A:G68	A:A:S67	3.71	No	No	0	7	7
53	A:A:S205	B:B:N119	8.94	No	Yes	0	7	9
54	A:A:E209	A:A:I207	5.47	No	No	0	9	9
55	A:A:I207	B:B:W99	5.87	No	Yes	1	9	9
56	A:A:I207	B:B:L117	4.28	No	No	1	9	9
57	A:A:F208	A:A:T210	6.49	No	No	0	5	7
58	A:A:E209	B:B:S97	4.31	No	No	0	9	8
59	A:A:F212	A:A:T210	7.78	Yes	No	0	9	7
60	A:A:H220	A:A:K211	17.03	No	No	0	7	4
61	A:A:F212	A:A:F219	9.65	Yes	Yes	0	9	8
62	A:A:F212	A:A:M221	4.98	Yes	No	0	9	8
63	A:A:N218	A:A:Q213	11.88	No	No	0	4	3
64	A:A:D215	A:A:V214	5.84	No	No	11	5	6
65	A:A:F219	A:A:V214	5.24	Yes	No	11	8	6
66	A:A:F376	A:A:V214	6.55	Yes	No	11	8	6
67	A:A:D215	A:A:F376	9.55	No	Yes	11	5	8
68	A:A:K216	R:R:S117	6.12	No	No	0	4	5
69	A:A:F219	A:A:V217	5.24	Yes	No	11	8	5
70	A:A:F376	A:A:V217	5.24	Yes	No	11	8	5
71	A:A:F219	A:A:F376	5.36	Yes	Yes	11	8	8
72	A:A:F219	A:A:V379	5.24	Yes	No	0	8	8
73	A:A:F222	A:A:H220	9.05	Yes	No	0	7	7
74	A:A:F222	A:A:F238	8.57	Yes	Yes	1	7	9
75	A:A:F222	A:A:V241	3.93	Yes	No	1	7	9
76	A:A:F222	B:B:W99	12.03	Yes	Yes	1	7	9
77	A:A:Q227	A:A:V224	7.16	Yes	No	1	9	9
78	A:A:V224	A:A:W234	17.16	No	Yes	1	9	9
79	A:A:Q227	A:A:W234	9.86	Yes	Yes	1	9	9
80	A:A:Q227	B:B:L117	5.32	Yes	No	1	9	9
81	A:A:Q227	B:B:N119	6.6	Yes	Yes	0	9	9
82	A:A:Q227	B:B:Y145	9.02	Yes	Yes	1	9	8
83	A:A:D229	A:A:R228	5.96	No	Yes	1	8	9
84	A:A:E230	A:A:R228	9.3	No	Yes	1	9	9
85	A:A:R228	B:B:T164	6.47	Yes	No	0	9	6
86	A:A:R228	B:B:D186	11.91	Yes	Yes	1	9	9
87	A:A:D229	A:A:E230	9.09	No	No	1	8	9
88	A:A:E230	B:B:D186	7.8	No	Yes	1	9	9
89	A:A:R231	A:A:W234	9	No	Yes	0	9	9
90	A:A:D272	A:A:R231	14.29	No	No	0	8	9
91	A:A:K233	A:A:R232	6.19	Yes	No	1	9	8
92	A:A:R232	B:B:C204	4.18	No	Yes	1	8	7
93	A:A:K233	A:A:Q236	6.78	Yes	No	1	9	8
94	A:A:K233	B:B:M188	10.08	Yes	No	0	9	8
95	A:A:K233	B:B:C204	4.85	Yes	Yes	1	9	7
96	A:A:K233	B:B:D228	9.68	Yes	Yes	1	9	9
97	A:A:F238	A:A:W234	4.01	Yes	Yes	1	9	9
98	A:A:Q236	A:A:W281	5.48	No	Yes	1	8	5
99	A:A:Q236	B:B:R314	4.67	No	Yes	1	8	8
100	A:A:C237	B:B:Y59	4.03	No	Yes	1	8	8
101	A:A:C237	B:B:Q75	4.58	No	Yes	1	8	9
102	A:A:C237	B:B:M101	4.86	No	Yes	1	8	9
103	A:A:F238	A:A:V241	5.24	Yes	No	1	9	9
104	A:A:F238	B:B:W99	14.03	Yes	Yes	1	9	9
105	A:A:D240	A:A:N239	6.73	No	No	1	6	8
106	A:A:N239	B:B:K57	9.79	No	Yes	1	8	9
107	A:A:N239	B:B:W332	12.43	No	Yes	1	8	9
108	A:A:D240	B:B:K57	5.53	No	Yes	1	6	9
109	A:A:I285	A:A:V241	4.61	No	No	0	7	9
110	A:A:I383	A:A:T242	4.56	No	No	21	8	8
111	A:A:I244	A:A:I285	7.36	No	No	0	8	7
112	A:A:I245	A:A:I288	4.42	Yes	No	0	7	9
113	A:A:F290	A:A:I245	3.77	Yes	Yes	0	9	7
114	A:A:D272	A:A:F246	5.97	No	No	0	8	9
115	A:A:F246	A:A:F273	6.43	No	Yes	0	9	9
116	A:A:F246	A:A:L289	3.65	No	Yes	0	9	9
117	A:A:F345	A:A:V248	7.87	Yes	No	0	8	7
118	A:A:D249	A:A:D252	18.63	No	Yes	16	8	8
119	A:A:D249	A:A:K293	4.15	No	Yes	0	8	9
120	A:A:Q294	A:A:S250	5.78	Yes	No	0	6	6
121	A:A:L297	A:A:S250	4.5	No	No	0	8	6
122	A:A:D252	A:A:R265	4.76	Yes	Yes	16	8	9
123	A:A:D252	A:A:L266	6.79	Yes	No	0	8	8
124	A:A:L297	A:A:Y253	5.86	No	No	0	8	8
125	A:A:K300	A:A:Y253	8.36	No	No	0	9	8
126	A:A:I308	A:A:Y253	20.55	No	No	0	7	8
127	A:A:F312	A:A:L266	7.31	Yes	No	0	8	8
128	A:A:I341	A:A:L266	4.28	No	No	0	8	8
129	A:A:F312	A:A:Q267	8.2	Yes	No	0	8	4
130	A:A:F345	A:A:L270	9.74	Yes	No	0	8	6
131	A:A:F273	A:A:V287	6.55	Yes	No	0	9	6
132	A:A:F273	A:A:F345	11.79	Yes	Yes	0	9	8
133	A:A:F273	A:A:I348	3.77	Yes	No	0	9	4
134	A:A:K274	A:A:N278	6.99	No	No	0	5	8
135	A:A:I348	A:A:K274	7.27	No	No	0	4	5
136	A:A:V287	A:A:W277	4.9	No	Yes	0	6	6
137	A:A:S349	A:A:W277	7.41	No	Yes	0	7	6
138	A:A:S352	A:A:W277	4.94	No	Yes	0	5	6
139	A:A:H357	A:A:W277	32.8	No	Yes	0	7	6
140	A:A:N278	A:A:S352	4.47	No	No	0	8	5
141	A:A:L282	A:A:N279	12.36	No	No	0	9	8
142	A:A:R280	A:A:W281	15.99	No	Yes	1	5	5
143	A:A:R280	B:B:D290	4.76	No	Yes	1	5	6
144	A:A:W281	B:B:D290	10.05	Yes	Yes	1	5	6
145	A:A:W281	B:B:R314	24.99	Yes	Yes	1	5	8
146	A:A:I285	A:A:L282	4.28	No	No	0	7	9
147	A:A:R283	A:A:R356	6.4	No	Yes	0	3	2
148	A:A:S286	A:A:Y360	5.09	No	Yes	7	8	8
149	A:A:I382	A:A:S286	9.29	No	No	7	6	8
150	A:A:A378	A:A:I288	4.87	No	No	0	7	9
151	A:A:L289	A:A:L291	6.92	Yes	No	0	9	8
152	A:A:F345	A:A:L289	9.74	Yes	Yes	0	8	9
153	A:A:C359	A:A:L289	4.76	No	Yes	0	5	9
154	A:A:F290	A:A:H362	11.31	Yes	Yes	17	9	9
155	A:A:F290	A:A:T364	5.19	Yes	Yes	17	9	9
156	A:A:F290	A:A:N371	12.08	Yes	No	17	9	8
157	A:A:F290	A:A:V375	3.93	Yes	No	0	9	9
158	A:A:L291	A:A:Q294	3.99	No	Yes	9	8	6
159	A:A:F363	A:A:L291	4.87	Yes	No	9	5	8
160	A:A:K293	A:A:N292	5.6	Yes	No	0	9	9
161	A:A:N292	A:A:T364	8.77	No	Yes	0	9	9
162	A:A:K293	A:A:L296	8.46	Yes	Yes	0	9	6
163	A:A:K338	A:A:Q294	10.85	No	Yes	9	5	6
164	A:A:F363	A:A:Q294	9.37	Yes	Yes	9	5	6
165	A:A:D295	A:A:L296	6.79	No	Yes	0	9	6
166	A:A:K300	A:A:S306	7.65	No	No	0	9	7
167	A:A:F315	A:A:I308	11.3	Yes	No	22	6	7
168	A:A:F340	A:A:I308	3.77	Yes	No	22	7	7
169	A:A:E309	A:A:F315	4.66	No	Yes	0	4	6
170	A:A:D310	A:A:Y311	9.2	No	No	0	3	6
171	A:A:F312	A:A:F340	7.5	Yes	Yes	0	8	7
172	A:A:F315	A:A:R336	11.76	Yes	No	0	6	5
173	A:A:F315	A:A:F340	8.57	Yes	Yes	22	6	7
174	A:A:F340	A:A:Y318	5.16	Yes	No	0	7	6
175	A:A:D343	A:A:Y318	11.49	No	No	0	3	6
176	A:A:E327	A:A:E330	11.42	No	Yes	0	4	3
177	A:A:E330	A:A:V334	8.56	Yes	No	0	3	4
178	A:A:E330	A:A:T335	5.64	Yes	No	0	3	4
179	A:A:D331	A:A:P332	11.27	No	No	0	4	1
180	A:A:D331	A:A:R333	13.1	No	No	0	4	5
181	A:A:F363	A:A:K338	16.13	Yes	No	9	5	5
182	A:A:R342	A:A:Y339	4.12	Yes	Yes	9	4	3
183	A:A:F363	A:A:Y339	8.25	Yes	Yes	9	5	3
184	A:A:E344	A:A:F340	8.16	No	Yes	0	5	7
185	A:A:D343	A:A:R342	4.76	No	Yes	0	3	4
186	A:A:P361	A:A:R342	17.29	No	Yes	0	5	4
187	A:A:F363	A:A:R342	10.69	Yes	Yes	9	5	4
188	A:A:E344	A:A:R347	15.12	No	No	0	5	4
189	A:A:L346	A:A:P361	6.57	No	No	0	4	5
190	A:A:G353	A:A:S352	3.71	No	No	0	4	5
191	A:A:G353	A:A:R356	4.5	No	Yes	0	4	2
192	A:A:D354	A:A:G355	5.03	No	No	0	3	2
193	A:A:G355	A:A:Y358	4.35	No	Yes	0	2	4
194	A:A:H357	A:A:R356	9.03	No	Yes	0	7	2
195	A:A:Y358	A:A:Y360	3.97	Yes	Yes	0	4	8
196	A:A:K385	A:A:Y358	8.36	No	Yes	0	5	4
197	A:A:F394	A:A:Y358	4.13	No	Yes	0	5	4
198	A:A:C359	A:A:P361	3.77	No	No	0	5	5
199	A:A:A378	A:A:Y360	6.67	No	Yes	0	7	8
200	A:A:D381	A:A:Y360	12.64	Yes	Yes	7	7	8
201	A:A:I382	A:A:Y360	8.46	No	Yes	7	6	8
202	A:A:Y360	R:R:K217	19.11	Yes	No	7	8	5
203	A:A:H362	A:A:T364	5.48	Yes	Yes	17	9	9
204	A:A:H362	A:A:N371	6.38	Yes	No	17	9	8
205	A:A:F374	A:A:H362	27.15	No	Yes	0	4	9
206	A:A:N371	A:A:T364	13.16	No	Yes	17	8	9
207	A:A:T369	A:A:V367	4.76	No	No	23	9	9
208	A:A:Q370	A:A:V367	10.03	No	No	23	4	9
209	A:A:Q370	A:A:T369	5.67	No	No	23	4	9
210	A:A:D377	A:A:K373	8.3	No	No	0	5	6
211	A:A:F374	R:R:T215	3.89	No	No	0	4	6
212	A:A:F376	A:A:T380	3.89	Yes	No	0	8	6
213	A:A:D377	R:R:K211	6.91	No	No	0	5	5
214	A:A:D377	R:R:T215	4.34	No	No	0	5	6
215	A:A:T380	R:R:H208	4.11	No	Yes	0	6	9
216	A:A:D381	A:A:K385	12.44	Yes	No	0	7	5
217	A:A:D381	R:R:H208	8.82	Yes	Yes	7	7	9
218	A:A:D381	R:R:M212	9.7	Yes	No	7	7	9
219	A:A:D381	R:R:K217	4.15	Yes	No	7	7	5
220	A:A:E386	A:A:I382	5.47	No	No	0	5	6
221	A:A:I383	A:A:N387	4.25	No	No	0	8	7
222	A:A:I384	R:R:H208	6.63	No	Yes	0	6	9
223	A:A:N387	R:R:K110	4.2	No	Yes	0	7	9
224	A:A:F394	A:A:L388	4.87	No	No	0	5	8
225	A:A:L388	R:R:I111	7.14	No	No	0	8	9
226	A:A:C391	R:R:Y107	5.38	No	Yes	0	5	9
227	A:A:C391	R:R:K110	4.85	No	Yes	0	5	9
228	A:A:C391	R:R:I111	4.91	No	No	0	5	9
229	A:A:L393	R:R:Y107	14.07	No	Yes	4	7	9
230	A:A:L393	W:W:?1	11.17	No	Yes	4	7	0
231	B:B:E3	B:B:L7	10.6	No	No	0	5	8
232	B:B:E3	G:G:I9	8.2	No	No	0	5	2
233	B:B:L4	G:G:S8	4.5	No	No	0	4	4
234	B:B:L4	G:G:I9	4.28	No	No	0	4	2
235	B:B:L7	G:G:A12	4.73	No	No	0	8	5
236	B:B:L7	G:G:R13	3.64	No	No	0	8	6
237	B:B:E12	B:B:R8	12.79	No	No	0	4	3
238	B:B:R8	G:G:L15	3.64	No	No	0	3	2
239	B:B:L14	G:G:L19	5.54	No	No	0	8	9
240	B:B:N16	B:B:R19	9.64	No	No	0	1	4
241	B:B:I18	B:B:Q17	5.49	Yes	No	0	7	4
242	B:B:Q17	G:G:A23	4.55	No	No	0	4	8
243	B:B:I18	B:B:R22	5.01	Yes	Yes	2	7	6
244	B:B:I18	G:G:E22	15.03	Yes	No	2	7	9
245	B:B:A21	G:G:R27	5.53	No	Yes	0	4	8
246	B:B:D258	B:B:R22	14.29	Yes	Yes	2	7	6
247	B:B:Q259	B:B:R22	4.67	No	Yes	0	6	6
248	B:B:R22	G:G:E22	4.65	Yes	No	2	6	9
249	B:B:C25	G:G:R27	4.18	No	Yes	0	3	8
250	B:B:C25	G:G:K29	6.47	No	No	0	3	4
251	B:B:A26	B:B:Q259	4.55	No	No	0	3	6
252	B:B:D27	G:G:K29	6.91	Yes	No	0	8	4
253	B:B:D27	G:G:V30	4.38	Yes	No	0	8	8
254	B:B:D27	G:G:S31	8.83	Yes	No	0	8	9
255	B:B:S31	B:B:T29	4.8	No	No	0	1	3
256	B:B:Q32	B:B:T29	18.43	No	No	0	1	3
257	B:B:L30	B:B:T34	5.9	No	No	0	5	5
258	B:B:L261	B:B:L30	6.92	No	No	0	5	5
259	B:B:L30	B:B:M262	8.48	No	No	0	5	4
260	B:B:I33	G:G:A34	4.87	No	No	0	3	6
261	B:B:I37	B:B:T34	4.56	Yes	No	8	2	5
262	B:B:L300	B:B:T34	7.37	Yes	No	8	6	5
263	B:B:I37	B:B:R283	5.01	Yes	Yes	8	2	9
264	B:B:I37	B:B:L300	7.14	Yes	Yes	8	2	6
265	B:B:I37	G:G:M38	5.83	Yes	No	0	2	4
266	B:B:D38	B:B:P39	6.44	No	No	0	1	1
267	B:B:K301	B:B:P39	6.69	No	No	0	5	1
268	B:B:R283	B:B:V40	7.85	Yes	Yes	8	9	3
269	B:B:D298	B:B:V40	5.84	No	Yes	8	9	3
270	B:B:V40	G:G:L51	4.47	Yes	Yes	8	3	6
271	B:B:Q44	B:B:R42	16.35	No	No	0	4	2
272	B:B:I43	B:B:L284	4.28	No	No	0	3	5
273	B:B:K337	B:B:T47	7.51	Yes	No	0	6	3
274	B:B:T47	B:B:W339	7.28	No	Yes	0	3	9
275	B:B:N340	B:B:R48	10.85	No	No	0	9	7
276	B:B:R49	B:B:T87	5.17	No	No	0	7	5
277	B:B:R52	B:B:T50	10.35	No	No	0	7	3
278	B:B:K337	B:B:T50	4.5	Yes	No	0	6	3
279	B:B:L51	B:B:L70	4.15	No	No	5	9	5
280	B:B:L51	B:B:W82	17.08	No	Yes	5	9	9
281	B:B:I338	B:B:L51	4.28	No	No	0	5	9
282	B:B:F335	B:B:R52	4.28	No	No	0	4	7
283	B:B:H54	B:B:I58	10.61	Yes	No	5	9	9
284	B:B:H54	B:B:S72	9.76	Yes	No	5	9	9
285	B:B:H54	B:B:S74	12.55	Yes	No	0	9	9
286	B:B:H54	B:B:I80	13.26	Yes	No	5	9	8
287	B:B:H54	B:B:W82	8.46	Yes	Yes	5	9	9
288	B:B:D76	B:B:L55	9.5	Yes	Yes	0	9	6
289	B:B:K57	B:B:Y59	4.78	Yes	Yes	1	9	8
290	B:B:K57	B:B:Q75	13.56	Yes	Yes	1	9	9
291	B:B:K57	B:B:W332	22.05	Yes	Yes	1	9	9
292	B:B:I58	B:B:S72	7.74	No	No	5	9	9
293	B:B:I58	B:B:L336	4.28	No	No	0	9	7
294	B:B:Q75	B:B:Y59	7.89	Yes	Yes	1	9	8
295	B:B:M101	B:B:Y59	9.58	Yes	Yes	1	9	8
296	B:B:W332	B:B:Y59	5.79	Yes	Yes	1	9	8
297	B:B:M61	B:B:W63	6.98	No	Yes	0	6	7
298	B:B:C317	B:B:M61	6.48	No	No	0	7	6
299	B:B:H62	B:B:R150	21.44	No	No	0	6	6
300	B:B:L70	B:B:W63	9.11	No	Yes	0	5	7
301	B:B:S84	B:B:W63	4.94	No	Yes	0	5	7
302	B:B:T321	B:B:W63	9.7	No	Yes	0	7	7
303	B:B:A328	B:B:W63	3.89	No	Yes	0	5	7
304	B:B:D66	B:B:L69	4.07	No	No	0	8	5
305	B:B:S67	B:B:Y85	5.09	Yes	Yes	6	5	4
306	B:B:S67	B:B:T321	4.8	Yes	No	6	5	7
307	B:B:D322	B:B:S67	4.42	No	Yes	6	1	5
308	B:B:D323	B:B:S67	8.83	Yes	Yes	6	7	5
309	B:B:D83	B:B:R68	10.72	No	No	0	8	5
310	B:B:R68	B:B:Y85	21.61	No	Yes	0	5	4
311	B:B:L69	B:B:Y105	7.03	No	Yes	0	5	6
312	B:B:L70	B:B:W82	5.69	No	Yes	5	5	9
313	B:B:L79	B:B:V71	4.47	No	Yes	0	7	8
314	B:B:C103	B:B:V71	5.12	No	Yes	0	8	8
315	B:B:V71	B:B:Y105	5.05	Yes	Yes	0	8	6
316	B:B:V112	B:B:V71	4.81	No	Yes	0	8	8
317	B:B:D76	B:B:S74	11.78	Yes	No	0	9	9
318	B:B:Q75	B:B:W99	5.48	Yes	Yes	1	9	9
319	B:B:D76	B:B:K78	12.44	Yes	No	0	9	8
320	B:B:I93	B:B:L79	5.71	Yes	No	0	7	7
321	B:B:L79	B:B:L95	5.54	No	Yes	0	7	8
322	B:B:I80	B:B:W82	17.62	No	Yes	5	8	9
323	B:B:I80	B:B:K89	4.36	No	Yes	5	8	9
324	B:B:H91	B:B:I81	6.63	No	No	0	5	7
325	B:B:I81	B:B:L126	4.28	No	No	0	7	5
326	B:B:K89	B:B:W82	10.44	Yes	Yes	5	9	9
327	B:B:D83	B:B:T86	10.12	No	No	15	8	6
328	B:B:S84	B:B:Y85	3.82	No	Yes	6	5	4
329	B:B:S84	G:G:F61	5.28	No	Yes	6	5	8
330	B:B:Y85	G:G:P60	13.91	Yes	Yes	6	4	9
331	B:B:Y85	G:G:F61	9.28	Yes	Yes	6	4	8
332	B:B:N88	B:B:T86	11.7	No	No	15	7	6
333	B:B:H91	B:B:V90	5.54	No	No	0	5	5
334	B:B:I93	B:B:Y124	7.25	Yes	Yes	0	7	6
335	B:B:I93	B:B:V133	7.68	Yes	No	0	7	4
336	B:B:L95	B:B:V100	4.47	Yes	No	0	8	9
337	B:B:L95	B:B:Y124	7.03	Yes	Yes	0	8	6
338	B:B:D118	B:B:S97	8.83	No	No	0	9	8
339	B:B:S98	B:B:W99	11.12	No	Yes	0	8	9
340	B:B:L117	B:B:W99	9.11	No	Yes	1	9	9
341	B:B:G116	B:B:M101	5.24	No	Yes	0	9	9
342	B:B:M101	B:B:Y145	7.18	Yes	Yes	1	9	8
343	B:B:C149	B:B:T102	6.76	No	No	0	8	8
344	B:B:L126	B:B:Y105	4.69	No	Yes	0	5	6
345	B:B:A106	B:B:F151	6.93	No	Yes	0	6	9
346	B:B:N110	B:B:S108	7.45	No	No	0	4	6
347	B:B:D154	B:B:S108	11.78	No	No	0	6	6
348	B:B:I123	B:B:Y111	4.84	Yes	No	0	6	4
349	B:B:N125	B:B:Y111	17.44	No	No	0	4	4
350	B:B:D154	B:B:Y111	8.05	No	No	0	6	4
351	B:B:L126	B:B:V112	4.47	No	No	0	5	8
352	B:B:A113	B:B:F151	4.16	No	Yes	0	9	9
353	B:B:C114	B:B:G115	3.92	No	No	0	8	9
354	B:B:C114	B:B:Y124	5.38	No	Yes	0	8	6
355	B:B:D118	B:B:I120	7	No	No	0	9	6
356	B:B:G144	B:B:N119	5.09	No	Yes	0	8	9
357	B:B:A140	B:B:I120	4.87	No	No	0	5	6
358	B:B:C121	B:B:L139	6.35	No	No	0	8	9
359	B:B:S122	B:B:Y124	6.36	No	Yes	0	8	6
360	B:B:F151	B:B:I123	5.02	Yes	Yes	0	9	6
361	B:B:I123	B:B:I171	5.89	Yes	No	0	6	6
362	B:B:V135	B:B:Y124	6.31	No	Yes	0	4	6
363	B:B:E130	B:B:T128	9.88	Yes	No	0	3	3
364	B:B:E130	B:B:R134	9.3	Yes	No	0	3	3
365	B:B:L139	B:B:W169	23.92	No	Yes	0	9	8
366	B:B:I171	B:B:L139	4.28	No	No	0	6	9
367	B:B:H142	B:B:L146	5.14	Yes	No	1	9	7
368	B:B:H142	B:B:T159	6.85	Yes	Yes	1	9	9
369	B:B:H142	B:B:S161	16.74	Yes	No	1	9	9
370	B:B:D163	B:B:H142	7.56	Yes	Yes	1	9	9
371	B:B:H142	B:B:W169	8.46	Yes	Yes	1	9	8
372	B:B:H142	B:B:Q176	6.18	Yes	Yes	1	9	4
373	B:B:D163	B:B:T143	4.34	Yes	No	0	9	5
374	B:B:G162	B:B:Y145	8.69	No	Yes	1	9	8
375	B:B:D186	B:B:Y145	12.64	Yes	Yes	1	9	8
376	B:B:L146	B:B:T159	7.37	No	Yes	1	7	9
377	B:B:S147	B:B:S160	4.89	No	No	0	9	6
378	B:B:C148	B:B:L190	4.76	No	No	0	6	5
379	B:B:L192	B:B:R150	4.86	No	No	0	5	6
380	B:B:F151	B:B:I157	6.28	Yes	No	0	9	7
381	B:B:L152	B:B:L192	4.15	No	No	0	3	5
382	B:B:L152	B:B:T196	5.9	No	No	0	3	1
383	B:B:L152	B:B:V213	4.47	No	No	0	3	4
384	B:B:D170	B:B:N155	8.08	No	No	0	9	3
385	B:B:L168	B:B:Q156	6.65	No	No	0	6	5
386	B:B:L190	B:B:V158	4.47	No	No	3	5	5
387	B:B:F199	B:B:V158	7.87	Yes	No	3	9	5
388	B:B:T159	B:B:W169	9.7	Yes	Yes	1	9	8
389	B:B:D163	B:B:S161	10.31	Yes	No	1	9	9
390	B:B:D186	B:B:G162	6.71	Yes	No	1	9	9
391	B:B:D163	B:B:T165	5.78	Yes	No	0	9	7
392	B:B:C166	B:B:V187	5.12	No	No	0	8	9
393	B:B:A167	B:B:W169	3.89	No	Yes	1	4	8
394	B:B:A167	B:B:Q176	7.58	No	Yes	1	4	4
395	B:B:L168	B:B:T178	5.9	No	No	0	6	4
396	B:B:Q176	B:B:W169	13.14	Yes	Yes	1	4	8
397	B:B:D170	B:B:T173	10.12	No	No	0	9	5
398	B:B:E172	B:B:T173	5.64	No	No	0	6	5
399	B:B:Q175	B:B:T173	7.09	No	No	0	4	5
400	B:B:T177	B:B:T178	6.28	No	No	0	4	4
401	B:B:F180	B:B:T178	6.49	Yes	No	0	7	4
402	B:B:F180	B:B:F199	12.86	Yes	Yes	3	7	9
403	B:B:F180	B:B:W211	16.04	Yes	Yes	3	7	8
404	B:B:G182	B:B:T181	3.64	No	No	0	6	2
405	B:B:H183	B:B:V187	8.3	Yes	No	3	9	9
406	B:B:H183	B:B:S201	5.58	Yes	No	3	9	9
407	B:B:A203	B:B:H183	7.32	No	Yes	3	8	9
408	B:B:D205	B:B:H183	8.82	Yes	Yes	3	9	9
409	B:B:H183	B:B:K209	22.27	Yes	Yes	3	9	6
410	B:B:H183	B:B:W211	8.46	Yes	Yes	3	9	8
411	B:B:D205	B:B:T184	4.34	Yes	No	0	9	3
412	B:B:S201	B:B:V187	4.85	No	No	3	9	9
413	B:B:F199	B:B:L190	4.87	Yes	No	3	9	5
414	B:B:F234	B:B:S191	10.57	No	No	0	5	8
415	B:B:A193	B:B:F234	5.55	No	No	0	4	5
416	B:B:G238	B:B:P194	4.06	No	No	0	7	4
417	B:B:R197	B:B:R214	9.6	No	No	0	5	9
418	B:B:L198	B:B:L210	4.15	No	No	0	3	5
419	B:B:L198	B:B:R219	3.64	No	No	0	3	5
420	B:B:F199	B:B:W211	12.03	Yes	Yes	3	9	8
421	B:B:L210	B:B:V200	4.47	No	No	0	5	6
422	B:B:I232	B:B:V200	6.14	No	No	0	8	6
423	B:B:F234	B:B:V200	10.49	No	No	0	5	6
424	B:B:S201	B:B:W211	6.18	No	Yes	3	9	8
425	B:B:A203	B:B:D205	4.63	No	Yes	3	8	9
426	B:B:C204	B:B:D228	4.67	Yes	Yes	1	7	9
427	B:B:D205	B:B:S207	8.83	Yes	No	0	9	5
428	B:B:K209	B:B:W211	5.8	Yes	Yes	3	6	8
429	B:B:C218	B:B:K209	8.08	No	Yes	3	5	6
430	B:B:K209	B:B:T221	10.51	Yes	No	0	6	7
431	B:B:L210	B:B:L255	4.15	No	No	0	5	6
432	B:B:C218	B:B:W211	10.45	No	Yes	3	5	8
433	B:B:D212	B:B:R214	7.15	No	No	0	9	9
434	B:B:D212	B:B:E215	11.69	No	No	0	9	3
435	B:B:D212	B:B:R219	7.15	No	No	0	9	5
436	B:B:E215	B:B:M217	4.06	No	No	0	3	3
437	B:B:C218	G:G:Q18	6.1	No	No	0	5	9
438	B:B:F222	B:B:Q220	9.37	Yes	No	2	8	7
439	B:B:D258	B:B:Q220	23.49	Yes	No	2	7	7
440	B:B:Q220	G:G:I25	8.23	No	No	0	7	2
441	B:B:T221	G:G:E22	5.64	No	No	0	7	9
442	B:B:F222	B:B:F241	13.93	Yes	Yes	2	8	6
443	B:B:F222	B:B:F253	10.72	Yes	Yes	2	8	6
444	B:B:D258	B:B:F222	11.94	Yes	Yes	2	7	8
445	B:B:G224	B:B:T223	5.46	No	No	0	6	2
446	B:B:H225	B:B:I229	10.61	Yes	No	2	9	7
447	B:B:H225	B:B:T243	6.85	Yes	No	2	9	8
448	B:B:H225	B:B:S245	12.55	Yes	No	2	9	9
449	B:B:D247	B:B:H225	10.08	Yes	Yes	2	9	9
450	B:B:H225	B:B:R251	14.67	Yes	Yes	2	9	8
451	B:B:D247	B:B:E226	9.09	Yes	No	0	9	3
452	B:B:D228	B:B:S227	5.89	Yes	No	0	9	6
453	B:B:D228	B:B:D246	11.98	Yes	No	0	9	9
454	B:B:I229	B:B:T243	6.08	No	No	2	7	8
455	B:B:D246	B:B:N230	6.73	No	No	0	9	9
456	B:B:F241	B:B:I232	5.02	Yes	No	0	6	8
457	B:B:F235	B:B:P236	10.11	Yes	Yes	12	6	7
458	B:B:A240	B:B:F235	4.16	No	Yes	0	6	6
459	B:B:F235	B:B:F278	17.15	Yes	Yes	12	6	7
460	B:B:F235	B:B:G282	6.02	Yes	No	12	6	9
461	B:B:F235	G:G:L37	7.31	Yes	No	0	6	7
462	B:B:F235	G:G:Y40	4.13	Yes	Yes	12	6	6
463	B:B:F278	B:B:P236	5.78	Yes	Yes	12	7	7
464	B:B:G282	B:B:P236	4.06	No	Yes	12	9	7
465	B:B:P236	G:G:Y40	5.56	Yes	Yes	12	7	6
466	B:B:N237	B:B:N239	10.9	No	No	0	5	2
467	B:B:N237	G:G:Y40	17.44	No	Yes	0	5	6
468	B:B:N239	B:B:R256	9.64	No	No	0	2	9
469	B:B:F241	B:B:F253	13.93	Yes	Yes	2	6	6
470	B:B:A242	B:B:F278	4.16	No	Yes	0	4	7
471	B:B:F253	B:B:T243	7.78	Yes	No	2	6	8
472	B:B:G244	B:B:I273	5.29	No	No	0	5	6
473	B:B:D247	B:B:S245	10.31	Yes	No	2	9	9
474	B:B:D247	B:B:T249	10.12	Yes	No	2	9	6
475	B:B:D247	B:B:R251	4.76	Yes	Yes	2	9	8
476	B:B:R251	B:B:T249	6.47	Yes	No	2	8	6
477	B:B:C250	B:B:Y264	4.03	No	Yes	0	8	5
478	B:B:C250	B:B:I273	6.55	No	No	0	8	6
479	B:B:F253	B:B:R251	8.55	Yes	Yes	2	6	8
480	B:B:E260	B:B:R251	15.12	No	Yes	2	6	8
481	B:B:R251	B:B:T263	11.64	Yes	No	0	8	1
482	B:B:L252	B:B:Y264	5.86	No	Yes	0	7	5
483	B:B:E260	B:B:F253	4.66	No	Yes	2	6	6
484	B:B:A257	B:B:D254	4.63	No	No	0	7	9
485	B:B:D254	B:B:L261	5.43	No	No	0	9	5
486	B:B:D254	G:G:A33	4.63	No	No	0	9	7
487	B:B:R256	G:G:I28	3.76	No	No	0	9	4
488	B:B:D258	G:G:R27	4.76	Yes	Yes	0	7	8
489	B:B:Q259	G:G:V30	7.16	No	No	0	6	8
490	B:B:M262	B:B:Y264	8.38	No	Yes	0	4	5
491	B:B:L285	B:B:Y264	4.69	No	Yes	0	6	5
492	B:B:W297	B:B:Y264	9.65	No	Yes	0	8	5
493	B:B:H266	B:B:N268	10.2	No	No	0	4	4
494	B:B:H266	B:B:I269	6.63	No	No	10	4	4
495	B:B:H266	B:B:R304	10.16	No	No	10	4	5
496	B:B:I269	B:B:R304	3.76	No	No	10	4	5
497	B:B:C271	B:B:D290	6.22	No	Yes	0	5	6
498	B:B:C271	B:B:D291	4.67	No	No	0	5	8
499	B:B:I273	B:B:Y289	4.84	No	Yes	0	6	7
500	B:B:D290	B:B:T274	4.34	Yes	No	1	6	8
501	B:B:R314	B:B:T274	9.06	Yes	No	1	8	8
502	B:B:L318	B:B:S275	6.01	No	No	0	6	8
503	B:B:G319	B:B:S277	3.71	No	No	0	5	5
504	B:B:S277	B:B:V320	4.85	No	No	0	5	7
505	B:B:F278	B:B:L285	14.61	Yes	No	0	7	6
506	B:B:A299	B:B:F278	4.16	No	Yes	0	5	7
507	B:B:S279	G:G:D48	8.83	No	Yes	0	9	9
508	B:B:S279	G:G:L50	4.5	No	No	0	9	9
509	B:B:S281	G:G:D48	5.89	No	Yes	0	9	9
510	B:B:D298	B:B:R283	17.87	No	Yes	8	9	9
511	B:B:L300	B:B:R283	13.36	Yes	Yes	8	6	9
512	B:B:R283	G:G:L51	4.86	Yes	Yes	8	9	6
513	B:B:L284	G:G:L51	4.15	No	Yes	0	5	6
514	B:B:L286	B:B:V296	7.45	No	No	0	7	5
515	B:B:L286	B:B:L318	4.15	No	No	0	7	6
516	B:B:L286	B:B:V327	4.47	No	Yes	0	7	6
517	B:B:A287	B:B:Y289	4	No	Yes	0	6	7
518	B:B:G288	B:B:Y289	4.35	No	Yes	0	7	7
519	B:B:C294	B:B:G288	3.92	No	No	0	5	7
520	B:B:N295	B:B:Y289	16.28	Yes	Yes	0	6	7
521	B:B:W297	B:B:Y289	6.75	No	Yes	0	8	7
522	B:B:D290	B:B:R314	14.29	Yes	Yes	1	6	8
523	B:B:D291	B:B:N293	13.46	No	Yes	0	8	5
524	B:B:N293	B:B:N295	4.09	Yes	Yes	10	5	6
525	B:B:N293	B:B:V307	5.91	Yes	No	10	5	3
526	B:B:C294	B:B:L308	9.52	No	No	0	5	7
527	B:B:N295	B:B:R304	9.64	Yes	No	10	6	5
528	B:B:N295	B:B:V307	5.91	Yes	No	10	6	3
529	B:B:L308	B:B:V296	4.47	No	No	0	7	5
530	B:B:L300	G:G:C41	4.76	Yes	No	0	6	7
531	B:B:L308	B:B:W339	13.67	No	Yes	0	7	9
532	B:B:H311	B:B:V315	5.54	Yes	No	18	9	7
533	B:B:H311	B:B:T329	5.48	Yes	No	0	9	8
534	B:B:H311	B:B:S331	11.16	Yes	No	18	9	9
535	B:B:D333	B:B:H311	7.56	Yes	Yes	18	9	9
536	B:B:H311	B:B:K337	13.1	Yes	Yes	0	9	6
537	B:B:R314	B:B:W332	27.99	Yes	Yes	1	8	9
538	B:B:S331	B:B:V315	4.85	No	No	18	9	7
539	B:B:S316	B:B:W332	4.94	No	Yes	0	9	9
540	B:B:L318	B:B:T329	4.42	No	No	0	6	8
541	B:B:D323	B:B:T321	8.67	Yes	No	6	7	7
542	B:B:D322	B:B:D323	5.32	No	Yes	6	1	7
543	B:B:D323	B:B:M325	9.7	Yes	No	0	7	5
544	B:B:G324	G:G:P49	4.06	No	No	0	9	7
545	B:B:M325	G:G:P49	5.03	No	No	0	5	7
546	B:B:M325	G:G:P60	5.03	No	Yes	0	5	9
547	B:B:A326	G:G:F61	8.32	No	Yes	0	7	8
548	B:B:V327	B:B:W339	3.68	Yes	Yes	0	6	9
549	B:B:T329	B:B:W339	9.7	No	Yes	0	8	9
550	B:B:D333	B:B:S331	5.89	Yes	No	18	9	9
551	B:B:D333	B:B:F335	9.55	Yes	No	0	9	4
552	B:B:I338	G:G:F61	5.02	No	Yes	0	5	8
553	B:B:N340	G:G:N59	13.62	No	No	0	9	9
554	B:B:N340	G:G:F61	4.83	No	Yes	0	9	8
555	G:G:I9	G:G:T6	6.08	No	No	0	2	3
556	G:G:R13	G:G:V16	3.92	No	No	0	6	7
557	G:G:K20	G:G:M21	5.76	No	No	0	6	1
558	G:G:I25	G:G:R27	5.01	No	Yes	0	2	8
559	G:G:I28	G:G:K32	7.27	No	No	0	4	5
560	G:G:H44	G:G:Y40	16.33	No	Yes	0	6	6
561	G:G:A43	G:G:H44	4.39	No	No	0	4	6
562	G:G:E47	G:G:H44	13.54	No	No	0	3	6
563	G:G:D48	G:G:P49	4.83	Yes	No	0	9	7
564	G:G:D48	G:G:L51	6.79	Yes	Yes	0	9	6
565	G:G:N59	G:G:V54	5.91	No	No	0	9	6
566	G:G:E58	G:G:S57	10.06	No	No	0	5	6
567	G:G:N59	G:G:P60	4.89	No	Yes	0	9	9
568	G:G:F61	G:G:P60	7.22	Yes	Yes	6	8	9
569	R:R:F9	R:R:I5	5.02	Yes	Yes	0	4	4
570	R:R:I5	R:R:R256	10.02	Yes	No	0	4	1
571	R:R:I5	R:R:N260	7.08	Yes	No	0	4	5
572	R:R:F9	R:R:I263	5.02	Yes	No	0	4	4
573	R:R:F9	R:R:L264	7.31	Yes	No	0	4	4
574	R:R:T10	R:R:W66	3.64	No	Yes	0	5	4
575	R:R:F11	R:R:V15	5.24	No	No	0	5	5
576	R:R:E16	R:R:V12	4.28	Yes	No	0	8	6
577	R:R:L13	R:R:W66	5.69	No	Yes	13	4	4
578	R:R:L13	R:R:Q266	3.99	No	Yes	13	4	3
579	R:R:L13	R:R:M270	4.24	No	Yes	0	4	4
580	R:R:E16	R:R:M270	4.06	Yes	Yes	0	8	4
581	R:R:A271	R:R:E16	4.53	No	Yes	0	6	8
582	R:R:E16	R:R:S274	4.31	Yes	No	0	8	7
583	R:R:F17	R:R:I18	3.77	Yes	No	0	5	6
584	R:R:F17	R:R:N21	14.5	Yes	No	25	5	6
585	R:R:F17	R:R:W60	10.02	Yes	No	25	5	3
586	R:R:F17	R:R:F63	40.73	Yes	No	0	5	4
587	R:R:F17	R:R:M270	3.73	Yes	Yes	0	5	4
588	R:R:I19	R:R:S274	6.19	No	No	0	5	7
589	R:R:N21	R:R:W60	11.3	No	No	25	6	3
590	R:R:N24	R:R:R55	9.64	No	Yes	0	9	9
591	R:R:I56	R:R:N24	5.66	No	No	0	6	9
592	R:R:N24	R:R:S277	5.96	No	No	0	9	9
593	R:R:F26	R:R:V30	7.87	No	No	0	8	8
594	R:R:F26	R:R:I281	3.77	No	No	0	8	9
595	R:R:A290	R:R:F26	4.16	No	No	0	5	8
596	R:R:A52	R:R:I27	4.87	No	No	0	8	9
597	R:R:I27	R:R:L287	7.14	No	No	0	9	9
598	R:R:D45	R:R:N31	6.73	No	No	0	8	8
599	R:R:N31	R:R:T49	10.24	No	No	0	8	6
600	R:R:C32	R:R:W35	3.92	No	No	0	4	5
601	R:R:D34	R:R:R39	5.96	No	No	0	6	6
602	R:R:D34	R:R:K286	8.3	No	No	0	6	8
603	R:R:V36	R:R:W35	4.9	No	No	0	5	5
604	R:R:K37	R:R:R39	4.95	No	No	0	6	6
605	R:R:D45	R:R:I41	5.6	No	No	0	8	6
606	R:R:I41	R:R:R46	3.76	No	No	0	6	5
607	R:R:S42	R:R:V44	4.85	No	No	0	8	6
608	R:R:D45	R:R:S42	8.83	No	No	0	8	8
609	R:R:F106	R:R:S43	5.28	Yes	No	0	7	6
610	R:R:F106	R:R:V44	5.24	Yes	No	0	7	6
611	R:R:V44	R:R:Y107	3.79	No	Yes	0	6	9
612	R:R:I47	R:R:L103	5.71	No	No	0	9	9
613	R:R:L280	R:R:L48	4.15	No	No	0	9	8
614	R:R:L48	R:R:N284	5.49	No	Yes	0	8	9
615	R:R:L51	R:R:R55	15.79	No	Yes	0	9	9
616	R:R:R55	R:R:Y272	7.2	Yes	Yes	4	9	5
617	R:R:P273	R:R:R55	7.21	No	Yes	0	8	9
618	R:R:H276	R:R:R55	12.41	Yes	Yes	4	9	9
619	R:R:I56	R:R:W60	4.7	No	No	0	6	3
620	R:R:I92	R:R:S57	4.64	No	No	0	4	3
621	R:R:I62	R:R:L58	4.28	No	Yes	0	4	4
622	R:R:L58	R:R:W89	4.56	Yes	Yes	14	4	4
623	R:R:L58	R:R:N93	4.12	Yes	Yes	14	4	8
624	R:R:M270	R:R:V59	4.56	Yes	No	0	4	7
625	R:R:L61	R:R:L85	4.15	No	No	0	4	2
626	R:R:I62	R:R:M270	10.2	No	Yes	0	4	4
627	R:R:F63	R:R:W66	5.01	No	Yes	0	4	4
628	R:R:L85	R:R:S65	4.5	No	No	0	2	4
629	R:R:V70	R:R:W66	15.94	No	Yes	13	4	4
630	R:R:F71	R:R:W66	6.01	No	Yes	13	4	4
631	R:R:Q266	R:R:W66	4.38	Yes	Yes	13	3	4
632	R:R:C67	R:R:F71	8.38	No	No	0	4	4
633	R:R:L75	R:R:V68	5.96	No	No	0	2	3
634	R:R:F76	R:R:V68	5.24	Yes	No	0	3	3
635	R:R:F76	R:R:S69	5.28	Yes	No	0	3	4
636	R:R:F71	R:R:V70	7.87	No	No	13	4	4
637	R:R:A74	R:R:F72	4.16	No	No	0	2	4
638	R:R:F72	R:R:L75	3.65	No	No	0	4	2
639	R:R:L75	R:R:M81	8.48	No	No	0	2	3
640	R:R:F76	R:R:M81	3.73	Yes	No	0	3	3
641	R:R:E79	R:R:K80	5.4	No	No	0	2	3
642	R:R:K80	R:R:R83	4.95	No	Yes	0	3	3
643	R:R:F172	R:R:F82	4.29	No	No	0	3	2
644	R:R:N87	R:R:R83	4.82	No	Yes	0	4	3
645	R:R:I152	R:R:R83	12.53	No	Yes	0	3	3
646	R:R:N153	R:R:R83	4.82	No	Yes	0	3	3
647	R:R:T90	R:R:W89	3.64	No	Yes	0	5	4
648	R:R:N93	R:R:W89	16.95	Yes	Yes	14	8	4
649	R:R:S183	R:R:W89	3.71	No	Yes	0	7	4
650	R:R:N144	R:R:T90	7.31	No	No	0	5	5
651	R:R:N93	R:R:V97	4.43	Yes	No	14	8	5
652	R:R:I187	R:R:N93	8.5	No	Yes	14	5	8
653	R:R:H94	R:R:W98	10.58	Yes	Yes	26	5	9
654	R:R:H94	R:R:T137	4.11	Yes	Yes	26	5	8
655	R:R:H94	R:R:L141	14.14	Yes	No	0	5	8
656	R:R:F186	R:R:H94	9.05	No	Yes	0	4	5
657	R:R:I187	R:R:V97	6.14	No	No	14	5	5
658	R:R:T101	R:R:W98	9.7	No	Yes	0	8	9
659	R:R:L133	R:R:W98	7.97	No	Yes	0	7	9
660	R:R:T137	R:R:W98	24.26	Yes	Yes	26	8	9
661	R:R:P190	R:R:W98	16.21	No	Yes	0	9	9
662	R:R:L103	R:R:Y107	12.89	No	Yes	0	9	9
663	R:R:L103	R:R:L280	4.15	No	No	0	9	9
664	R:R:G104	W:W:?1	8.28	No	Yes	0	8	0
665	R:R:M197	R:R:T105	6.02	No	No	0	8	7
666	R:R:F106	R:R:K110	8.69	Yes	Yes	24	7	9
667	R:R:F106	R:R:V126	3.93	Yes	No	24	7	7
668	R:R:Y107	W:W:?1	13.25	Yes	Yes	4	9	0
669	R:R:F108	R:R:L109	4.87	Yes	No	0	8	7
670	R:R:A112	R:R:F108	4.16	No	Yes	0	8	8
671	R:R:F108	R:R:M197	9.95	Yes	No	0	8	8
672	R:R:F108	R:R:L200	6.09	Yes	No	0	8	7
673	R:R:L109	R:R:V126	4.47	No	No	0	7	7
674	R:R:K110	R:R:V126	6.07	Yes	No	24	9	7
675	R:R:F114	R:R:F119	9.65	No	No	0	8	9
676	R:R:F114	R:R:F203	4.29	No	No	0	8	5
677	R:R:F114	R:R:S204	5.28	No	No	0	8	9
678	R:R:I118	R:R:N116	5.66	No	No	0	4	8
679	R:R:F119	R:R:K123	7.44	No	No	0	9	9
680	R:R:R125	R:R:Y121	7.2	No	No	0	8	5
681	R:R:L122	R:R:V129	7.45	No	No	0	8	6
682	R:R:K128	R:R:R125	3.71	No	No	0	6	8
683	R:R:K127	R:R:L131	5.64	No	No	0	7	6
684	R:R:F140	R:R:T137	3.89	No	Yes	0	3	8
685	R:R:F140	R:R:F186	4.29	No	No	0	3	4
686	R:R:L143	R:R:L147	5.54	No	No	0	3	4
687	R:R:I148	R:R:N144	4.25	No	No	0	4	5
688	R:R:F186	R:R:N144	26.58	No	No	0	4	5
689	R:R:I145	R:R:N149	4.25	No	No	0	6	4
690	R:R:H151	R:R:L147	7.71	Yes	No	0	2	4
691	R:R:I148	R:R:I179	4.42	No	No	0	4	3
692	R:R:H151	R:R:L178	6.43	Yes	No	0	2	3
693	R:R:H151	R:R:T182	8.21	Yes	No	0	2	6
694	R:R:F175	R:R:I152	3.77	Yes	No	0	2	3
695	R:R:F175	R:R:S155	17.18	Yes	No	0	2	3
696	R:R:F172	R:R:F175	4.29	No	Yes	0	3	2
697	R:R:F172	R:R:S176	3.96	No	No	0	3	4
698	R:R:E258	R:R:T173	8.47	No	No	0	4	3
699	R:R:F175	R:R:I179	5.02	Yes	No	0	2	3
700	R:R:L257	R:R:S177	4.5	No	No	0	1	3
701	R:R:F248	R:R:L181	6.09	Yes	No	27	4	2
702	R:R:L181	R:R:V251	7.45	No	Yes	0	2	3
703	R:R:L181	R:R:W252	7.97	No	No	27	2	3
704	R:R:F247	R:R:T184	9.08	Yes	No	0	3	5
705	R:R:F248	R:R:T184	7.78	Yes	No	0	4	5
706	R:R:F248	R:R:V185	3.93	Yes	No	0	4	6
707	R:R:F188	R:R:S244	7.93	No	No	0	3	5
708	R:R:F188	R:R:L245	3.65	No	No	0	3	4
709	R:R:F191	R:R:Y240	12.38	No	Yes	0	7	8
710	R:R:S194	W:W:?1	8.48	No	Yes	0	8	0
711	R:R:L195	R:R:L199	6.92	No	No	0	7	4
712	R:R:F237	R:R:L195	3.65	No	No	0	6	7
713	R:R:F198	R:R:L199	3.65	Yes	No	0	7	4
714	R:R:F198	R:R:I202	6.28	Yes	No	0	7	8
715	R:R:F198	R:R:V233	5.24	Yes	No	0	7	7
716	R:R:F198	R:R:I234	3.77	Yes	No	0	7	5
717	R:R:F198	R:R:F237	13.93	Yes	No	4	7	6
718	R:R:F198	W:W:?1	11.8	Yes	Yes	4	7	0
719	R:R:L201	W:W:?1	6.7	No	Yes	0	9	0
720	R:R:F203	R:R:K207	8.69	No	No	0	5	7
721	R:R:K210	R:R:W206	22.05	No	No	0	6	4
722	R:R:H208	R:R:M212	9.19	Yes	No	7	9	9
723	R:R:K210	R:R:R209	7.43	No	No	0	6	6
724	R:R:M212	R:R:T215	4.52	No	No	0	9	6
725	R:R:F236	R:R:Y240	11.35	Yes	Yes	4	9	8
726	R:R:F236	R:R:Y272	4.13	Yes	Yes	4	9	5
727	R:R:C275	R:R:F236	4.19	No	Yes	0	4	9
728	R:R:F236	R:R:V279	6.55	Yes	No	0	9	7
729	R:R:F237	W:W:?1	4.92	No	Yes	4	6	0
730	R:R:F243	R:R:L239	8.53	No	No	0	7	7
731	R:R:S244	R:R:Y240	5.09	No	Yes	0	5	8
732	R:R:Y240	R:R:Y272	12.91	Yes	Yes	4	8	5
733	R:R:F243	R:R:I242	6.28	No	No	0	7	5
734	R:R:F247	R:R:V251	3.93	Yes	Yes	0	3	3
735	R:R:F247	R:R:L264	7.31	Yes	No	0	3	4
736	R:R:F247	R:R:M268	17.42	Yes	No	0	3	5
737	R:R:F248	R:R:W252	7.02	Yes	No	27	4	3
738	R:R:S250	R:R:S254	6.52	No	No	0	3	2
739	R:R:L257	R:R:L261	9.69	No	No	0	1	1
740	R:R:E258	R:R:E259	20.3	No	No	0	4	4
741	R:R:I262	R:R:Q266	5.49	No	Yes	0	1	3
742	R:R:I263	R:R:Q266	4.12	No	Yes	0	4	3
743	R:R:H276	R:R:Y272	25.04	Yes	Yes	4	9	5
744	R:R:H276	R:R:L280	10.29	Yes	No	0	9	9
745	R:R:H276	W:W:?1	7.26	Yes	Yes	4	9	0
746	R:R:I281	R:R:L287	5.71	No	No	0	9	9
747	R:R:K286	R:R:N284	4.2	No	Yes	0	8	9
748	R:R:L287	R:R:N284	12.36	No	Yes	0	9	9
749	R:R:K285	R:R:R288	3.71	No	No	0	6	8
750	B:B:A73	B:B:C103	3.61	No	No	0	9	8
751	B:B:R256	G:G:D36	3.57	No	No	0	9	5
752	B:B:G202	B:B:I229	3.53	No	No	0	6	7
753	G:G:P55	G:G:V54	3.53	No	No	0	5	6
754	A:A:I235	A:A:W234	3.52	No	Yes	0	9	9
755	R:R:I41	R:R:W35	3.52	No	No	0	6	5
756	R:R:L122	R:R:Y121	3.52	No	No	0	8	5
757	A:A:P321	A:A:T320	3.5	No	No	0	5	1
758	A:A:P326	A:A:T335	3.5	No	No	0	1	4
759	A:A:G47	A:A:K53	3.49	No	No	0	9	9
760	A:A:G52	A:A:K293	3.49	No	Yes	0	9	9
761	B:B:G53	B:B:K89	3.49	No	Yes	0	9	9
762	B:B:G182	G:G:K14	3.49	No	No	0	6	4
763	B:B:G310	B:B:K337	3.49	No	Yes	0	5	6
764	R:R:G269	R:R:M268	3.49	No	No	0	4	5
765	R:R:K207	R:R:W206	3.48	No	No	0	7	4
766	B:B:C148	B:B:S160	3.44	No	No	0	6	6
767	B:B:C233	B:B:S277	3.44	No	No	0	3	5
768	B:B:G77	B:B:L95	3.42	No	Yes	0	8	8
769	B:B:G330	B:B:L336	3.42	No	No	0	5	7
770	R:R:L61	R:R:W89	3.42	No	Yes	0	4	4
771	R:R:A112	R:R:S204	3.42	No	No	0	8	9
772	A:A:A269	A:A:V248	3.39	No	No	0	9	7
773	B:B:I93	B:B:P94	3.39	Yes	No	0	7	5
774	B:B:G131	B:B:N132	3.39	No	No	0	4	3
775	B:B:A231	B:B:V276	3.39	No	No	0	5	6
776	B:B:A305	B:B:V296	3.39	No	No	0	4	5
777	B:B:N313	B:B:W332	3.39	No	Yes	0	7	9
778	R:R:I189	R:R:P190	3.39	No	No	0	6	9
779	B:B:C149	B:B:T159	3.38	No	Yes	0	8	9
780	B:B:D76	B:B:G77	3.35	Yes	No	0	9	8
781	B:B:D290	B:B:G272	3.35	Yes	No	0	6	4
782	A:A:Q35	R:R:W124	3.29	No	No	0	3	4
783	B:B:H62	B:B:Y105	3.27	No	Yes	0	6	6
784	B:B:E130	B:B:G131	3.27	Yes	No	0	3	4
785	B:B:E260	B:B:G224	3.27	No	No	0	6	6
786	B:B:S227	B:B:S245	3.26	No	No	0	6	9
787	R:R:S54	R:R:S96	3.26	No	No	0	9	7
788	A:A:I26	B:B:A92	3.25	Yes	No	0	9	6
789	A:A:A243	A:A:I288	3.25	No	No	0	8	9
790	R:R:S96	R:R:V97	3.23	No	No	0	7	5
791	R:R:S177	R:R:V251	3.23	No	Yes	0	3	3
792	A:A:D343	A:A:P321	3.22	No	No	0	3	5
793	B:B:D195	B:B:P194	3.22	No	No	0	5	4
794	A:A:V301	A:A:V334	3.21	No	No	0	7	4
795	B:B:R49	G:G:F61	3.21	No	Yes	0	7	8
796	B:B:V320	B:B:V327	3.21	No	Yes	0	7	6
797	R:R:V12	R:R:V267	3.21	No	No	0	6	4
798	R:R:V180	R:R:V251	3.21	No	Yes	0	3	3
799	A:A:S349	A:A:T350	3.2	No	No	0	7	4
800	B:B:R46	B:B:R48	3.2	No	No	0	5	7
801	B:B:S265	B:B:T249	3.2	No	No	0	2	6
802	B:B:S265	B:B:T263	3.2	No	No	0	2	1
803	R:R:T105	R:R:V129	3.17	No	No	0	7	6
804	R:R:A100	R:R:L51	3.15	No	No	0	8	9
805	B:B:T165	B:B:T181	3.14	No	No	0	7	2
806	A:A:A48	A:A:N50	3.13	No	Yes	0	8	9
807	B:B:A231	B:B:N230	3.13	No	No	0	5	9
808	B:B:A309	B:B:N293	3.13	No	Yes	0	3	5
809	B:B:I123	B:B:S136	3.1	Yes	No	0	6	4
810	B:B:I232	B:B:S189	3.1	No	No	0	8	7
811	R:R:I156	R:R:S155	3.1	No	No	0	3	3
812	B:B:A28	B:B:D27	3.09	No	Yes	0	4	8
813	R:R:I19	R:R:V15	3.07	No	No	0	5	5
814	R:R:I202	R:R:V230	3.07	No	No	0	8	7
815	R:R:I234	R:R:V230	3.07	No	No	0	5	7
816	A:A:C365	A:A:Q370	3.05	No	No	0	8	4
817	A:A:I56	A:A:T55	3.04	No	No	0	7	9
818	B:B:M45	B:B:V327	3.04	No	Yes	0	4	6
819	B:B:F180	B:B:G216	3.01	Yes	No	0	7	4
820	A:A:G68	A:A:R61	3	No	No	0	7	8
821	A:A:L296	A:A:S251	3	Yes	No	0	6	9
822	B:B:G174	B:B:R137	3	No	No	0	4	5
823	R:R:K6	R:R:T10	3	No	No	0	4	5
824	R:R:L282	R:R:S232	3	No	No	0	6	7
825	A:A:L297	A:A:V301	2.98	No	No	0	8	7
826	G:G:L15	G:G:V16	2.98	No	No	0	2	7
827	A:A:N292	A:A:V247	2.96	No	No	0	9	7
828	G:G:L51	G:G:T52	2.95	Yes	No	0	6	4
829	R:R:L239	R:R:T235	2.95	No	No	0	7	7
830	A:A:I235	A:A:I276	2.94	No	No	0	9	8
831	A:A:I244	A:A:I276	2.94	No	No	0	8	8
832	A:A:I384	R:R:M205	2.92	No	No	0	6	9
833	B:B:I33	G:G:M38	2.92	No	No	0	3	4
834	B:B:N125	B:B:T128	2.92	No	No	0	4	3
835	B:B:G64	B:B:Y105	2.9	No	Yes	0	5	6
836	B:B:G109	B:B:Y105	2.9	No	Yes	0	5	6
837	B:B:F151	B:B:P107	2.89	Yes	No	0	9	6
838	A:A:I26	A:A:L30	2.85	Yes	No	0	9	5
839	B:B:I18	G:G:L19	2.85	Yes	No	0	7	9
840	R:R:I92	R:R:L58	2.85	No	Yes	0	4	4
841	B:B:I171	B:B:N155	2.83	No	No	0	6	3
842	B:B:Q176	B:B:T179	2.83	Yes	No	0	4	4
843	R:R:I145	R:R:N87	2.83	No	No	0	6	4
844	R:R:I152	R:R:N149	2.83	No	No	0	3	4
845	B:B:K127	B:B:N110	2.8	No	No	0	4	4
846	G:G:M21	G:G:N24	2.8	No	No	0	1	1
847	A:A:A337	A:A:F315	2.77	No	Yes	0	8	6
848	B:B:A11	B:B:R8	2.77	No	No	0	5	3
849	B:B:A104	B:B:F151	2.77	No	Yes	0	7	9
850	B:B:A208	B:B:F241	2.77	No	Yes	0	6	6
851	B:B:K280	G:G:D48	2.77	No	Yes	0	1	9
852	B:B:D298	B:B:K301	2.77	No	No	0	9	5
853	R:R:L134	R:R:L99	2.77	No	No	0	8	5
854	R:R:G283	W:W:?1	2.76	No	Yes	0	7	0
855	A:A:M60	A:A:Q59	2.72	No	No	0	9	9
856	A:A:D331	A:A:L302	2.71	No	No	0	4	2
857	G:G:E17	G:G:M21	2.71	No	No	0	6	1
858	R:R:E259	R:R:K6	2.7	No	No	0	4	4
859	A:A:A324	A:A:Y339	2.67	No	Yes	0	3	3
860	B:B:D153	B:B:D154	2.66	No	No	0	5	6
861	B:B:D312	B:B:D333	2.66	No	Yes	0	5	9
862	B:B:R137	B:B:S136	2.64	No	No	0	5	4
863	B:B:F335	B:B:S334	2.64	No	No	0	4	4
864	R:R:F76	R:R:S65	2.64	Yes	No	0	3	4
865	R:R:F247	R:R:S265	2.64	Yes	No	0	3	4
866	A:A:D323	A:A:E322	2.6	No	No	0	4	1
867	A:A:A39	R:R:W124	2.59	No	No	0	5	4
868	R:R:F188	R:R:T192	2.59	No	No	0	3	4
869	B:B:E3	B:B:Q6	2.55	No	No	0	5	1
870	R:R:F63	R:R:I14	2.51	No	No	0	4	4
871	A:A:T325	A:A:Y339	2.5	No	Yes	0	2	3
872	A:A:K389	A:A:R356	2.48	No	Yes	0	4	2
873	A:A:F394	A:A:K389	2.48	No	No	0	5	4
874	B:B:K15	B:B:R19	2.48	No	No	0	6	4
875	R:R:T253	R:R:W252	2.43	No	No	0	4	3
876	R:R:L282	R:R:R288	2.43	No	No	0	6	8
877	R:R:L298	R:R:R299	2.43	No	No	0	5	7
878	B:B:F292	B:B:N313	2.42	No	No	0	4	7
879	R:R:F119	R:R:N116	2.42	No	No	0	9	8
880	A:A:N254	A:A:R265	2.41	No	Yes	0	9	9
881	A:A:N254	A:A:Y311	2.33	No	No	0	9	6
882	A:A:E314	A:A:F340	2.33	No	Yes	0	6	7
883	R:R:L193	R:R:W98	2.28	No	Yes	0	5	9
884	R:R:F175	R:R:H151	2.26	Yes	Yes	0	2	2
885	A:A:G65	A:A:G66	2.11	No	No	0	5	3
886	A:A:G206	A:A:G225	2.11	No	No	28	8	9
887	A:A:G206	A:A:G226	2.11	No	No	28	8	9
888	A:A:G225	A:A:G226	2.11	No	No	28	9	9
889	R:R:G2	R:R:G3	2.11	No	No	0	4	4
890	A:A:G329	A:A:P328	2.03	No	No	0	7	1
891	B:B:C204	B:B:G185	1.96	Yes	No	0	7	5
892	R:R:C67	R:R:G64	1.96	No	No	0	4	3
893	B:B:A305	B:B:G306	1.95	No	No	0	4	4
894	B:B:A193	B:B:P194	1.87	No	No	0	4	4
895	B:B:G109	B:B:S108	1.86	No	No	0	5	6
896	B:B:G162	B:B:S161	1.86	No	No	1	9	9
897	R:R:G20	R:R:S274	1.86	No	No	0	9	7
898	R:R:G23	R:R:S277	1.86	No	No	0	7	9
899	B:B:G41	B:B:V40	1.84	No	Yes	0	1	3
900	R:R:G102	R:R:V130	1.84	No	No	0	5	7
901	R:R:G102	R:R:T105	1.82	No	No	0	5	7
902	B:B:A60	B:B:C103	1.81	No	No	0	7	8
903	G:G:P55	G:G:S57	1.78	No	No	0	5	6
904	R:R:G2	R:R:I5	1.76	No	Yes	0	4	4
905	A:A:P332	A:A:T335	1.75	No	No	0	1	4
906	B:B:P107	B:B:T65	1.75	No	No	0	6	1
907	G:G:P53	G:G:T52	1.75	No	No	0	8	4
908	A:A:G304	A:A:K305	1.74	No	No	0	5	3
909	B:B:S281	G:G:A45	1.71	No	No	0	9	4
910	R:R:G23	R:R:L22	1.71	No	No	0	7	4
911	A:A:G226	B:B:N119	1.7	No	Yes	0	9	9
912	A:A:A298	A:A:V334	1.7	No	No	0	4	4
913	A:A:G392	R:R:N284	1.7	No	Yes	0	8	9
914	R:R:G158	R:R:N157	1.7	No	No	0	2	1
915	A:A:E330	A:A:G329	1.64	Yes	No	0	3	7
916	B:B:A248	B:B:I269	1.62	No	No	0	5	4
917	R:R:A28	R:R:I53	1.62	No	No	0	7	6
918	B:B:A26	B:B:K23	1.61	No	No	0	3	2
919	A:A:T325	R:R:V216	1.59	No	No	0	2	7
920	R:R:T137	R:R:V136	1.59	Yes	No	0	8	6
921	B:B:A11	G:G:L19	1.58	No	No	0	5	9
922	R:R:A50	R:R:L99	1.58	No	No	0	6	5
923	A:A:E322	A:A:P321	1.57	No	No	0	1	5
924	R:R:T86	R:R:T90	1.57	No	No	0	3	5
925	A:A:A39	A:A:N218	1.56	No	No	0	5	4
926	R:R:I8	R:R:S7	1.55	No	No	0	6	3
927	R:R:I56	R:R:S25	1.55	No	No	0	6	5
928	R:R:I281	R:R:S291	1.55	No	No	0	9	5
929	R:R:K40	R:R:S42	1.53	No	No	0	6	8
930	B:B:A28	B:B:Q32	1.52	No	No	0	4	1
931	G:G:A7	G:G:Q11	1.52	No	No	0	4	3
932	G:G:A10	G:G:Q11	1.52	No	No	0	2	3
933	G:G:C41	G:G:E42	1.52	No	No	0	7	1
934	R:R:I53	R:R:T49	1.52	No	No	0	6	6
935	R:R:K128	R:R:V132	1.52	No	No	0	6	3
936	R:R:I249	R:R:T253	1.52	No	No	0	4	4
937	A:A:A316	A:A:E309	1.51	No	No	0	2	4
938	R:R:M81	R:R:T78	1.51	No	No	0	3	4
939	R:R:G229	R:R:R228	1.5	No	No	0	9	5
940	R:R:L141	R:R:V91	1.49	No	No	0	8	6
941	R:R:L131	R:R:V130	1.49	No	No	0	6	7
942	R:R:L295	R:R:V294	1.49	No	No	0	7	5
943	R:R:I88	R:R:M84	1.46	No	No	0	3	3
944	A:A:I26	A:A:K25	1.45	Yes	No	0	9	5
945	R:R:I33	R:R:K37	1.45	No	No	0	4	6
946	A:A:F312	A:A:P313	1.44	Yes	No	0	8	6
947	R:R:F72	R:R:P73	1.44	No	No	0	4	4
948	B:B:E138	B:B:V135	1.43	No	No	0	6	4
949	R:R:I33	R:R:L29	1.43	No	No	0	4	5
950	R:R:I47	R:R:L99	1.43	No	No	0	9	5
951	R:R:I88	R:R:L61	1.43	No	No	0	3	4
952	R:R:I234	R:R:L238	1.43	No	No	0	5	5
953	A:A:I384	R:R:N113	1.42	No	No	0	6	8
954	B:B:L14	G:G:K20	1.41	No	No	0	8	6
955	B:B:G141	B:B:W169	1.41	No	Yes	0	5	8
956	R:R:K123	R:R:L120	1.41	No	No	0	9	7
957	A:A:K17	A:A:N14	1.4	No	No	0	4	3
958	A:A:K24	A:A:N23	1.4	No	No	0	4	7
959	B:B:K301	B:B:N35	1.4	No	No	0	5	1
960	G:G:D26	G:G:I25	1.4	No	No	0	1	2
961	R:R:A146	R:R:F142	1.39	No	No	0	4	3
962	A:A:D390	A:A:K389	1.38	No	No	0	4	4
963	R:R:L295	R:R:L298	1.38	No	No	0	7	5
964	A:A:L270	A:A:N271	1.37	No	No	0	6	5
965	B:B:N35	B:B:N36	1.36	No	No	0	1	1
966	R:R:K285	R:R:Q289	1.36	No	No	0	6	7
967	B:B:D267	B:B:N268	1.35	No	No	0	3	4
968	A:A:E299	A:A:L296	1.33	No	Yes	0	6	6
969	B:B:A302	B:B:Y264	1.33	No	Yes	0	2	5
970	R:R:H151	R:R:I150	1.33	Yes	No	0	2	3
971	B:B:R96	B:B:S97	1.32	No	No	0	6	8
972	B:B:D5	B:B:Q6	1.31	No	No	0	1	1
973	R:R:F142	R:R:V139	1.31	No	No	0	3	4
974	A:A:D11	A:A:E10	1.3	No	No	0	2	2
975	A:A:R283	A:A:T284	1.29	No	No	0	3	4
976	B:B:Q13	B:B:Q9	1.28	No	No	0	1	3
977	R:R:F9	R:R:I8	1.26	Yes	No	0	4	6
978	A:A:I62	A:A:R61	1.25	No	No	0	9	8
979	B:B:Q44	B:B:R46	1.17	No	No	0	4	5
980	A:A:E268	A:A:R265	1.16	No	Yes	0	9	9
981	B:B:E130	B:B:R129	1.16	Yes	No	0	3	3
982	R:R:H227	R:R:R228	1.13	No	No	0	9	5
983	B:B:R49	G:G:R62	1.07	No	No	0	7	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	A:A:I26	3.3425	4	0	9
2	A:A:N50	8.04	5	16	9
3	A:A:F212	8.43	4	0	9
4	A:A:F219	6.146	5	11	8
5	A:A:F222	8.422	5	1	7
6	A:A:Q227	7.592	5	1	9
7	A:A:R228	8.41	4	1	9
8	A:A:K233	7.516	5	1	9
9	A:A:W234	8.71	5	1	9
10	A:A:F238	8.562	5	1	9
11	A:A:I245	5.26	4	0	7
12	A:A:D252	8.8925	4	16	8
13	A:A:R265	6.3	4	16	9
14	A:A:F273	7.135	4	0	9
15	A:A:W277	12.5125	4	0	6
16	A:A:W281	14.1275	4	1	5
17	A:A:L289	6.2675	4	0	9
18	A:A:F290	7.256	5	17	9
19	A:A:K293	5.425	4	0	9
20	A:A:Q294	7.4975	4	9	6
21	A:A:L296	4.895	4	0	6
22	A:A:F312	6.1125	4	0	8
23	A:A:F315	7.812	5	22	6
24	A:A:E330	6.815	4	0	3
25	A:A:Y339	4.385	4	9	3
26	A:A:F340	5.915	6	22	7
27	A:A:R342	9.215	4	9	4
28	A:A:F345	9.785	4	0	8
29	A:A:R356	5.6025	4	0	2
30	A:A:Y358	5.2025	4	0	4
31	A:A:Y360	9.32333	6	7	8
32	A:A:H362	12.58	4	17	9
33	A:A:F363	9.862	5	9	5
34	A:A:T364	8.15	4	17	9
35	A:A:F376	6.118	5	11	8
36	A:A:D381	9.55	5	7	7
37	B:B:I18	7.095	4	2	7
38	B:B:R22	7.155	4	2	6
39	B:B:D27	5.8025	4	0	8
40	B:B:I37	5.635	4	8	2
41	B:B:V40	5	4	8	3
42	B:B:H54	10.928	5	5	9
43	B:B:L55	8.2125	4	20	6
44	B:B:K57	11.142	5	1	9
45	B:B:Y59	6.414	5	1	8
46	B:B:W63	6.924	5	0	7
47	B:B:S67	5.785	4	6	5
48	B:B:V71	4.8625	4	0	8
49	B:B:Q75	7.8775	4	1	9
50	B:B:D76	9.2675	4	0	9
51	B:B:W82	11.858	5	5	9
52	B:B:Y85	10.742	5	6	4
53	B:B:K89	6.07667	6	5	9
54	B:B:I93	6.0075	4	0	7
55	B:B:L95	5.115	4	0	8
56	B:B:W99	9.60667	6	1	9
57	B:B:M101	6.715	4	1	9
58	B:B:Y105	4.30667	6	0	6
59	B:B:N119	5.5825	4	0	9
60	B:B:I123	4.7125	4	0	6
61	B:B:Y124	6.466	5	0	6
62	B:B:E130	5.9025	4	0	3
63	B:B:H142	8.48833	6	1	9
64	B:B:Y145	9.3825	4	1	8
65	B:B:F151	4.675	6	0	9
66	B:B:T159	6.825	4	1	9
67	B:B:D163	6.9975	4	1	9
68	B:B:W169	10.0867	6	1	8
69	B:B:Q176	7.4325	4	1	4
70	B:B:F180	9.6	4	3	7
71	B:B:H183	10.125	6	3	9
72	B:B:D186	9.765	4	1	9
73	B:B:F199	9.4075	4	3	9
74	B:B:C204	3.915	4	1	7
75	B:B:D205	6.655	4	3	9
76	B:B:K209	11.665	4	3	6
77	B:B:W211	9.82667	6	3	8
78	B:B:F222	11.49	4	2	8
79	B:B:H225	10.952	5	2	9
80	B:B:D228	8.055	4	1	9
81	B:B:F235	8.14667	6	12	6
82	B:B:P236	6.3775	4	12	7
83	B:B:F241	8.9125	4	2	6
84	B:B:D247	8.872	5	2	9
85	B:B:R251	10.2017	6	2	8
86	B:B:F253	9.128	5	2	6
87	B:B:D258	13.62	4	2	7
88	B:B:Y264	5.65667	6	0	5
89	B:B:F278	9.172	5	12	7
90	B:B:R283	9.79	5	8	9
91	B:B:Y289	7.244	5	0	7
92	B:B:D290	7.16833	6	1	6
93	B:B:N293	6.6475	4	10	5
94	B:B:N295	8.98	4	10	6
95	B:B:L300	8.1575	4	8	6
96	B:B:H311	8.568	5	18	9
97	B:B:R314	16.2	5	1	8
98	B:B:D323	8.13	4	6	7
99	B:B:V327	3.6	4	0	6
100	B:B:W332	12.765	6	1	9
101	B:B:D333	6.415	4	18	9
102	B:B:K337	7.15	4	0	6
103	B:B:W339	8.5825	4	0	9
104	G:G:R27	4.87	4	0	8
105	G:G:Y40	10.865	4	12	6
106	G:G:D48	5.822	5	0	9
107	G:G:L51	4.644	5	8	6
108	G:G:P60	7.7625	4	6	9
109	G:G:F61	6.16571	7	6	8
110	R:R:I5	5.97	4	0	4
111	R:R:F9	4.6525	4	0	4
112	R:R:E16	4.295	4	0	8
113	R:R:F17	14.55	5	25	5
114	R:R:R55	10.45	5	4	9
115	R:R:L58	3.9525	4	14	4
116	R:R:W66	6.77833	6	13	4
117	R:R:F76	4.2225	4	0	3
118	R:R:R83	6.78	4	0	3
119	R:R:W89	6.456	5	14	4
120	R:R:N93	8.5	4	14	8
121	R:R:H94	9.47	4	26	5
122	R:R:W98	11.8333	6	26	9
123	R:R:F106	5.785	4	24	7
124	R:R:Y107	9.876	5	4	9
125	R:R:F108	6.2675	4	0	8
126	R:R:K110	5.9525	4	24	9
127	R:R:T137	8.4625	4	26	8
128	R:R:H151	5.188	5	0	2
129	R:R:F175	6.504	5	0	2
130	R:R:F198	7.445	6	4	7
131	R:R:H208	7.1875	4	7	9
132	R:R:F236	6.555	4	4	9
133	R:R:Y240	10.4325	4	4	8
134	R:R:F247	8.076	5	0	3
135	R:R:F248	6.205	4	27	4
136	R:R:V251	4.455	4	0	3
137	R:R:Q266	4.495	4	13	3
138	R:R:M270	5.358	5	0	4
139	R:R:Y272	12.32	4	4	5
140	R:R:H276	13.75	4	4	9
141	R:R:N284	5.9375	4	0	9
142	W:W:?1	8.29111	9	4	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	B:B:D76	B:B:S74	15.4626	11.78	Yes	No	0	9	9
2	B:B:H54	B:B:S74	15.3255	12.55	Yes	No	0	9	9
3	B:B:H54	B:B:W82	11.9323	8.46	Yes	Yes	5	9	9
4	B:B:D76	B:B:L55	21.4927	9.5	Yes	Yes	0	9	6
5	A:A:Y37	B:B:L55	21.902	14.07	No	Yes	0	4	6
6	A:A:R42	A:A:Y37	22.1815	19.55	No	No	0	9	4
7	A:A:D240	A:A:R42	22.3254	5.96	No	No	0	6	9
8	A:A:D240	B:B:K57	16.5158	5.53	No	Yes	1	6	9
9	B:B:K57	B:B:Q75	39.0847	13.56	Yes	Yes	1	9	9
10	B:B:Q75	B:B:W99	68.0785	5.48	Yes	Yes	1	9	9
11	A:A:F238	B:B:W99	65.9428	14.03	Yes	Yes	1	9	9
12	A:A:F238	A:A:W234	65.5045	4.01	Yes	Yes	1	9	9
13	A:A:R231	A:A:W234	97.9488	9	No	Yes	0	9	9
14	A:A:D272	A:A:R231	97.8212	14.29	No	No	0	8	9
15	A:A:D272	A:A:F246	97.6944	5.97	No	No	0	8	9
16	A:A:F246	A:A:F273	75.0077	6.43	No	Yes	0	9	9
17	A:A:F273	A:A:V287	75.9632	6.55	Yes	No	0	9	6
18	A:A:V287	A:A:W277	75.7941	4.9	No	Yes	0	6	6
19	A:A:H357	A:A:W277	74.8821	32.8	No	Yes	0	7	6
20	A:A:H357	A:A:R356	74.7188	9.03	No	Yes	0	7	2
21	A:A:K389	A:A:R356	74.4539	2.48	No	Yes	0	4	2
22	A:A:F394	A:A:K389	74.1329	2.48	No	No	0	5	4
23	A:A:F394	A:A:L388	61.0084	4.87	No	No	0	5	8
24	A:A:L388	R:R:I111	60.8201	7.14	No	No	0	8	9
25	A:A:C391	R:R:I111	60.6315	4.91	No	No	0	5	9
26	A:A:C391	R:R:K110	10.2196	4.85	No	Yes	0	5	9
27	A:A:Y358	A:A:Y360	12.7711	3.97	Yes	Yes	0	4	8
28	A:A:F394	A:A:Y358	21.208	4.13	No	Yes	0	5	4
29	A:A:D252	A:A:L266	10.2774	6.79	Yes	No	0	8	8
30	A:A:F312	A:A:L266	10.9683	7.31	Yes	No	0	8	8
31	A:A:F312	A:A:F340	12.0068	7.5	Yes	Yes	0	8	7
32	A:A:F340	A:A:Y318	16.0642	5.16	Yes	No	0	7	6
33	A:A:D343	A:A:Y318	16.5619	11.49	No	No	0	3	6
34	A:A:D343	A:A:R342	19.071	4.76	No	Yes	0	3	4
35	A:A:C359	A:A:P361	10.2669	3.77	No	No	0	5	5
36	A:A:C359	A:A:L289	10.5338	4.76	No	Yes	0	5	9
37	A:A:F246	A:A:L289	27.4381	3.65	No	Yes	0	9	9
38	A:A:F363	A:A:L291	11.3059	4.87	Yes	No	9	5	8
39	A:A:L289	A:A:L291	18.2321	6.92	Yes	No	0	9	8
40	A:A:D381	R:R:H208	11.5873	8.82	Yes	Yes	7	7	9
41	B:B:M101	B:B:Y59	31.3452	9.58	Yes	Yes	1	9	8
42	B:B:M101	B:B:Y145	31.4131	7.18	Yes	Yes	1	9	8
43	A:A:Q227	B:B:Y145	32.6678	9.02	Yes	Yes	1	9	8
44	A:A:K233	A:A:Q236	83.4039	6.78	Yes	No	1	9	8
45	A:A:Q236	B:B:R314	78.3684	4.67	No	Yes	1	8	8
46	B:B:R314	B:B:W332	100	27.99	Yes	Yes	1	8	9
47	B:B:K57	B:B:W332	34.9246	22.05	Yes	Yes	1	9	9
48	A:A:K233	B:B:D228	82.2256	9.68	Yes	Yes	1	9	9
49	B:B:D290	B:B:R314	31.1901	14.29	Yes	Yes	1	6	8
50	A:A:C391	R:R:Y107	52.1993	5.38	No	Yes	0	5	9
51	R:R:Y107	W:W:?1	44.8596	13.25	Yes	Yes	4	9	0
52	B:B:D228	B:B:S227	81.2202	5.89	Yes	No	0	9	6
53	B:B:S227	B:B:S245	80.9967	3.26	No	No	0	6	9
54	B:B:H225	B:B:S245	53.072	12.55	Yes	No	2	9	9
55	B:B:H225	B:B:T243	25.6419	6.85	Yes	No	2	9	8
56	B:B:F253	B:B:T243	25.4165	7.78	Yes	No	2	6	8
57	B:B:F222	B:B:F253	59.9414	10.72	Yes	Yes	2	8	6
58	B:B:D258	B:B:F222	56.9997	11.94	Yes	Yes	2	7	8
59	B:B:D258	B:B:R22	48.4744	14.29	Yes	Yes	2	7	6
60	B:B:I18	B:B:R22	18.7989	5.01	Yes	Yes	2	7	6
61	B:B:I18	G:G:L19	16.5198	2.85	Yes	No	0	7	9
62	B:B:A11	G:G:L19	11.8099	1.58	No	No	0	5	9
63	B:B:A11	B:B:R8	11.0241	2.77	No	No	0	5	3
64	B:B:H225	B:B:R251	26.6796	14.67	Yes	Yes	2	9	8
65	B:B:F253	B:B:R251	50.8306	8.55	Yes	Yes	2	6	8
66	B:B:D247	B:B:S245	27.7009	10.31	Yes	No	2	9	9
67	B:B:D247	B:B:R251	26.6885	4.76	Yes	Yes	2	9	8
68	B:B:R22	G:G:E22	21.1487	4.65	Yes	No	2	6	9
69	B:B:L30	B:B:T34	12.8365	5.9	No	No	0	5	5
70	B:B:L30	B:B:M262	13.9815	8.48	No	No	0	5	4
71	B:B:M262	B:B:Y264	14.2232	8.38	No	Yes	0	4	5
72	B:B:W297	B:B:Y264	22.7098	9.65	No	Yes	0	8	5
73	B:B:W297	B:B:Y289	22.967	6.75	No	Yes	0	8	7
74	B:B:T221	G:G:E22	20.4385	5.64	No	No	0	7	9
75	B:B:K209	B:B:T221	19.6552	10.51	Yes	No	0	6	7
76	B:B:K209	B:B:W211	11.0084	5.8	Yes	Yes	3	6	8
77	B:B:F241	B:B:F253	15.5691	13.93	Yes	Yes	2	6	6
78	B:B:F241	B:B:I232	14.1719	5.02	Yes	No	0	6	8
79	B:B:I232	B:B:V200	12.6008	6.14	No	No	0	8	6
80	B:B:N295	B:B:Y289	32.4384	16.28	Yes	Yes	0	6	7
81	B:B:C271	B:B:D290	35.6342	6.22	No	Yes	0	5	6
82	B:B:C271	B:B:D291	35.3546	4.67	No	No	0	5	8
83	B:B:N293	B:B:N295	34.2639	4.09	Yes	Yes	10	5	6
84	B:B:D291	B:B:N293	35.0834	13.46	No	Yes	0	8	5
85	R:R:H276	W:W:?1	41.7575	7.26	Yes	Yes	4	9	0
86	R:R:H276	R:R:R55	39.6316	12.41	Yes	Yes	4	9	9
87	R:R:N24	R:R:R55	38.9544	9.64	No	Yes	0	9	9
88	R:R:I56	R:R:N24	38.0824	5.66	No	No	0	6	9
89	R:R:I56	R:R:W60	37.645	4.7	No	No	0	6	3
90	R:R:F17	R:R:W60	37.1891	10.02	Yes	No	25	5	3
91	R:R:F17	R:R:F63	10.2179	40.73	Yes	No	0	5	4
92	R:R:I263	R:R:Q266	14.0676	4.12	No	Yes	0	4	3
93	R:R:F9	R:R:I263	13.5856	5.02	Yes	No	0	4	4
94	R:R:F17	R:R:M270	26.5855	3.73	Yes	Yes	0	5	4
95	R:R:I62	R:R:M270	16.7937	10.2	No	Yes	0	4	4
96	R:R:I62	R:R:L58	16.5579	4.28	No	Yes	0	4	4
97	R:R:L58	R:R:W89	14.6302	4.56	Yes	Yes	14	4	4
98	A:A:Q227	A:A:W234	32.8792	9.86	Yes	Yes	1	9	9
99	B:B:W332	B:B:Y59	59.7883	5.79	Yes	Yes	1	9	8
100	B:B:Q75	B:B:Y59	29.0068	7.89	Yes	Yes	1	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
A:A:C391	R:R:Y107	5.38	0	No	Yes	5	9	2	1
A:A:L393	R:R:Y107	14.07	4	No	Yes	7	9	1	1
A:A:L393	W:W:?1	11.17	4	No	Yes	7	0	1	0
R:R:V44	R:R:Y107	3.79	0	No	Yes	6	9	2	1
R:R:R55	R:R:Y272	7.2	4	Yes	Yes	9	5	2	2
R:R:H276	R:R:R55	12.41	4	Yes	Yes	9	9	1	2
R:R:L103	R:R:Y107	12.89	0	No	Yes	9	9	2	1
R:R:L103	R:R:L280	4.15	0	No	No	9	9	2	2
R:R:G104	W:W:?1	8.28	0	No	Yes	8	0	1	0
R:R:Y107	W:W:?1	13.25	4	Yes	Yes	9	0	1	0
R:R:S194	W:W:?1	8.48	0	No	Yes	8	0	1	0
R:R:L195	R:R:L199	6.92	0	No	No	7	4	2	2
R:R:F237	R:R:L195	3.65	4	No	No	6	7	1	2
R:R:F198	R:R:L199	3.65	4	Yes	No	7	4	1	2
R:R:F198	R:R:I202	6.28	4	Yes	No	7	8	1	2
R:R:F198	R:R:V233	5.24	4	Yes	No	7	7	1	2
R:R:F198	R:R:I234	3.77	4	Yes	No	7	5	1	2
R:R:F198	R:R:F237	13.93	4	Yes	No	7	6	1	1
R:R:F198	W:W:?1	11.8	4	Yes	Yes	7	0	1	0
R:R:L201	W:W:?1	6.7	0	No	Yes	9	0	1	0
R:R:F237	W:W:?1	4.92	4	No	Yes	6	0	1	0
R:R:H276	R:R:Y272	25.04	4	Yes	Yes	9	5	1	2
R:R:H276	R:R:L280	10.29	4	Yes	No	9	9	1	2
R:R:H276	W:W:?1	7.26	4	Yes	Yes	9	0	1	0
R:R:G283	W:W:?1	2.76	0	No	Yes	7	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
90.00	Single	8XQO	Aristolochic acid A	8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
81.82	Single	8XQL	Aristolochic acid A	8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
80.00	Single	8XQN	Aristolochic acid A	8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
72.73	Single	8RQL	Flufenamic acid	8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
72.73	Single	8XQS	Flufenamic acid	8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
45.45	Single	8XQP	Aristolochic acid A	8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
37.50	Single	8J20	AR420626	8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
35.29	Single	8TB7	PubChem 168510218	8TB7-GPR61-PubChem 168510218
27.78	Single	8ZYY	SBI-553	8ZYY-NTS₁-Neurotensin peptide 8-13-SBI-553-Arrestin2
21.05	Single	8ZYU	SBI-553	8ZYU-NTS₁-Neurotensin peptide 8-13-SBI-553-Arrestin2
18.18	Single	8FN0	SBI-553	8FN0-NTS₁-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
18.18	Single	8ZYT	SBI-553	8ZYT-NTS₁-Neurotensin peptide 8-13-SBI-553-Arrestin2
17.65	Single	4Z9G	CP-376395	4Z9G-CRF₁-CP-376395
16.67	Single	8GTG	BMK-I152	8GTG-CRF₁-BMK-I152
13.33	Single	7CA3	rac-BHFF	7CA3-GABA_B1, GABA_B2-rac-BHFF
13.33	Single	8HNN	SCH546738	8HNN-CXCR3-SCH546738
12.50	Single	4K5Y	CP-376395	4K5Y-CRF₁-CP-376395
12.50	Single	7C7Q	BHFF	7C7Q-GABA_B1, GABA_B2-Baclofen-BHFF
11.11	Single	7RBT	LSN3556672	7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
11.11	Single	8GTI	BMK-C205	8GTI-CRF₁-BMK-C205
11.11	Single	8JPC	SBI-553; GDP; Mg	8JPC-NTS₁-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
11.11	Single	8JPF	SBI-553	8JPF-NTS₁-Neurotensin-SBI-553
10.00	Single	8JPB	SBI-553; GDP; Mg	8JPB-NTS₁-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
9.52	Single	8GTM	BMK-C203	8GTM-CRF₁-BMK-C203
8.33	Single	4PXF	Octyl-Beta-D-Glucopyranoside	4PXF-Rhodopsin-Octyl-β-D-Glucopyranoside-Arrestin1 Finger Loop
8.33	Single	6UO8	GS39783	6UO8-GABA_B1, GABA_B2-SKF97541-GS39783
7.14	Single	7EB2	rac-BHFF	7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
6.67	Single	5EE7	MK0893	5EE7-Glucagon-MK0893
6.25	Single	5VEX	NNC0640	5VEX-GLP-1-NNC0640
6.25	Single	6KK7	PF-06372222	6KK7-GLP-1-PF-06372222
5.88	Single	5VEW	PF-06372222	5VEW-GLP-1-PF-06372222
5.88	Single	6KJV	PF-06372222	6KJV-GLP-1-PF-06372222
5.88	Single	6KK1	PF-06372222	6KK1-GLP-1-PF-06372222
5.56	Single	5XEZ	NNC0640	5XEZ-Glucagon-NNC0640
5.56	Single	8XQL	Aristolochic acid A	8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
5.26	Single	5XF1	NNC0640	5XF1-Glucagon-NNC0640
5.26	Single	6QZH	Cmp2105; Na	6QZH-CCR7-Cmp2105; Na
5.00	Single	6LFL	PubChem 153466996	6LFL-CXCR2-PubChem 153466996
5.00	Single	8T6J	CDPPB	8T6J-mGlu5; mGlu5-CDPPB
5.00	Single	8T6J	CDPPB	8T6J-mGlu5; mGlu5-CDPPB
4.76	Single	8X0B	VU0424465	8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.76	Single	8X0F	VU0424465	8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
4.55	Single	5LWE	Vercirnon	5LWE-CCR9-Vercirnon
4.55	Single	8JR9	PCO371	8JR9-PTH1-PCO371-chim(NtGi1-Gs)/β1/γ2
4.35	Single	5CGD	HTL14242	5CGD-mGlu₅-HTL14242
4.35	Single	6LN2	PF-06372222	6LN2-GLP-1-PF-06372222
4.00	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
3.57	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
3.33	Single	3VG9	Antibody	3VG9-A_2A-ZM-241385-Antibody
3.03	Single	3VGA	Antibody	3VGA-A_2A-ZM-241385-Antibody

PDB Summary
PDB	8XQR
Class	T2
SubFamily	Sensory
Type	Taste2
SubType	TAS2R14
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	Flufenamic acid
Protein Partners	Gt3/Beta1/Gamma1
PDB Resolution	3.2
Date	2024-07-10
D.O.I.	doi.org/10.1038/s41586-024-07569-9

Net Summary
I_min	3.64
Number of Linked Nodes	865
Number of Links	983
Number of Hubs	142
Number of Links mediated by Hubs	528
Number of Communities	28
Number of Nodes involved in Communities	188
Number of Links involved in Communities	256

Path Summary
Number Of Nodes in MetaPath	101
Number Of Links MetaPath	100
Number of Shortest Paths	1352541
Length Of Smallest Path	3
Average Path Length	33.1131
Length of Longest Path	64
Minimum Path Strength	1.315
Average Path Strength	8.4773
Maximum Path Strength	27.615
Minimum Path Correlation	0.7
Average Path Correlation	0.98384
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.38095
Average % Of Corr. Nodes	45.0431
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	51.068
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• cation binding • ion binding • binding • metal ion binding • small molecule binding • hydrolase activity, acting on glycosyl bonds • alpha-sialidase activity • hydrolase activity, hydrolyzing O-glycosyl compounds • hydrolase activity • exo-alpha-sialidase activity • catalytic activity • taste receptor activity • molecular transducer activity • transmembrane signaling receptor activity • signaling receptor activity • bitter taste receptor activity • G protein-coupled receptor activity • membrane lipid metabolic process • sphingolipid catabolic process • ceramide metabolic process • ganglioside catabolic process • carbohydrate derivative catabolic process • glycosphingolipid catabolic process • catabolic process • lipid catabolic process • glycolipid metabolic process • glycosphingolipid metabolic process • liposaccharide metabolic process • carbohydrate derivative metabolic process • primary metabolic process • sphingolipid metabolic process • membrane lipid catabolic process
Gene Ontology	Biological Process	• membrane lipid metabolic process • sphingolipid catabolic process • ceramide metabolic process • ganglioside catabolic process • carbohydrate derivative catabolic process • glycosphingolipid catabolic process • catabolic process • lipid catabolic process • glycolipid metabolic process • glycosphingolipid metabolic process • liposaccharide metabolic process • carbohydrate derivative metabolic process • primary metabolic process • sphingolipid metabolic process • membrane lipid catabolic process • glycolipid catabolic process • ceramide catabolic process • metabolic process • cellular process • amide metabolic process • ganglioside metabolic process • lipid metabolic process • carbohydrate metabolic process • oligosaccharide catabolic process • oligosaccharide metabolic process • carbohydrate catabolic process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • signal transduction • cell communication • multicellular organismal process • system process • nervous system process • detection of chemical stimulus involved in sensory perception of bitter taste • detection of chemical stimulus involved in sensory perception of taste • detection of stimulus • sensory perception of chemical stimulus • sensory perception • sensory perception of taste • response to chemical • detection of chemical stimulus • sensory perception of bitter taste • detection of stimulus involved in sensory perception • detection of chemical stimulus involved in sensory perception • cellular anatomical structure • membrane • intracellular anatomical structure • cytoplasm • cell periphery • plasma membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • endomembrane system • trans-Golgi network
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	FLF
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	FLF
Name	Flufenamic acid
Synonyms	FLUFENAMIC ACID
Identifier
Formula	C14 H10 F3 N O2
Molecular Weight	281.23
SMILES
PubChem	3371
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	0
Total Bonds	31
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	A
Protein	G Protein α Sub unit
UniProt	P63092
Sequence	>8XQR_Chain_A T E D Q R N E E K A Q R E A N K K I E K Q L Q K D K Q V Y R A T H R L L L L G A D N S G K S T I V K Q M R I L H G G S G S G I F E T K F Q V D K V N F H M F D V G G Q R D E R R K W I Q C F N D V T A I I F V V D S S D Y N R L Q E A L N D F K S I W N N R W L R T I S V I L F L N K Q D L L A E K V L A G K S K I E D Y F P E F A R Y T T P E D A T P E P G E D P R V T R A K Y F I R D E F L R I S T A S G D G R H Y C Y P H F T C A V D T Q N V K F V F D A V T D I I I K E N L K D C G L F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	B
Protein	G Protein β Sub unit
UniProt	P62873
Sequence	>8XQR_Chain_B E L D Q L R Q E A E Q L K N Q I R D A R K A C A D A T L S Q I T N N I D P V G R I Q M R T R R T L R G H L A K I Y A M H W G T D S R L L V S A S Q D G K L I I W D S Y T T N K V H A I P L R S S W V M T C A Y A P S G N Y V A C G G L D N I C S I Y N L K T R E G N V R V S R E L A G H T G Y L S C C R F L D D N Q I V T S S G D T T C A L W D I E T G Q Q T T T F T G H T G D V M S L S L A P D T R L F V S G A C D A S A K L W D V R E G M C R Q T F T G H E S D I N A I C F F P N G N A F A T G S D D A T C R L F D L R A D Q E L M T Y S H D N I I C G I T S V S F S K S G R L L L A G Y D D F N C N V W D A L K A D R A G V L A G H D N R V S C L G V T D D G M A V A T G S W D S F L K I W N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	G
Protein	G Protein γ Sub unit
UniProt	P59768
Sequence	>8XQR_Chain_G T A S I A Q A R K L V E Q L K M E A N I D R I K V S K A A A D L M A Y C E A H A K E D P L L T P V P A S E N P F R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	Q9NYV8
Sequence	>8XQR_Chain_R G G V I K S I F T F V L I V E F I I G N L G N S F I A L V N C I D W V K G R K I S S V D R I L T A L A I S R I S L V W L I F G S W C V S V F F P A L F A T E K M F R M L T N I W T V I N H F S V W L A T G L G T F Y F L K I A N F S N S I F L Y L K W R V K K V V L V L L L V T S V F L F L N I A L I N I H I N A S I N G F T R F S S L I V L T S T V F I F I P F T L S L A M F L L L I F S M W K H R K K M Q H T V K T K A H R G V K S V I T F F L L Y A I F S L S F F I S V W T S E R L E E N L I I L S Q V M G M A Y P S C H S C V L I L G N K K L R Q A S L S V L L W L R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8RQL	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Flufenamic acid	Flufenamic acid	chim(NtGi1-Gt3)/β1/γ2	3.03	2024-11-27	doi.org/10.1038/s41467-024-54157-6
	8RQL (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Flufenamic acid	Flufenamic acid		3.03	2024-11-27	doi.org/10.1038/s41467-024-54157-6
	8XQR	T2	Sensory	Taste2	TAS2R14	Homo sapiens	-	Flufenamic acid	Gt3/β1/γ1	3.2	2024-07-10	doi.org/10.1038/s41586-024-07569-9
	8XQR (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	-	Flufenamic acid		3.2	2024-07-10	doi.org/10.1038/s41586-024-07569-9
	8XQS	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Flufenamic acid	Gi1/β1/γ1	3.3	2024-07-10	doi.org/10.1038/s41586-024-07569-9
	8XQS (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Flufenamic acid		3.3	2024-07-10	doi.org/10.1038/s41586-024-07569-9
	8XQL	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A	Gt3/β1/γ1	2.99	2024-07-10	doi.org/10.1038/s41586-024-07569-9
	8XQL (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A		2.99	2024-07-10	doi.org/10.1038/s41586-024-07569-9
	8XQN	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A	Gi1/β1/γ1	3.05	2024-07-10	doi.org/10.1038/s41586-024-07569-9
	8XQN (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A		3.05	2024-07-10	doi.org/10.1038/s41586-024-07569-9
	8XQO	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A	Gi1/β1/γ1	2.77	2024-07-10	doi.org/10.1038/s41586-024-07569-9
	8XQO (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A		2.77	2024-07-10	doi.org/10.1038/s41586-024-07569-9
	8XQP	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A	Gt3/β1/γ1	3.29	2024-07-10	doi.org/10.1038/s41586-024-07569-9
	8XQP (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A		3.29	2024-07-10	doi.org/10.1038/s41586-024-07569-9
	8XQT	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	-	Gi1/β1/γ1	2.94	2024-07-10	doi.org/10.1038/s41586-024-07569-9
	8XQT (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	-		2.94	2024-07-10	doi.org/10.1038/s41586-024-07569-9

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