CodeFLF
NameFlufenamic acid
SynonymsFLUFENAMIC ACID
Identifier
FormulaC14 H10 F3 N O2
Molecular Weight281.23
SMILES
PubChem3371
Formal Charge0
Total Atoms30
Total Chiral Atoms0
Total Bonds31
Total Aromatic Bonds12
Networks6
 missing image

This ligand is also present in the following 6 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8RQL T2 Sensory Taste2 TAS2R14 Homo Sapiens Flufenamic acid Flufenamic acid chim(NtGi1-Gt3)/Beta1/Gamma2 3.03 2024-11-27  10.1038/s41467-024-54157-6

A 2D representation of the interactions of FLF in 8RQL
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:S65 6.06 0 Yes No 0 4 0 1
L:L:?1 R:R:F76 21.63 0 Yes No 0 3 0 1
L:L:?1 R:R:F82 11.8 0 Yes No 0 2 0 1
L:L:?1 R:R:W89 17.47 0 Yes Yes 0 4 0 1
L:L:?1 R:R:F172 14.75 0 Yes No 0 3 0 1
L:L:?1 R:R:S176 3.64 0 Yes No 0 4 0 1
L:L:?1 R:R:I262 10.37 0 Yes No 0 1 0 1
L:L:?1 R:R:S265 4.85 0 Yes No 0 4 0 1
R:R:L61 R:R:W89 3.42 0 No Yes 4 4 2 1
R:R:I62 R:R:W89 4.7 0 No Yes 4 4 2 1
R:R:F76 R:R:V68 9.18 0 No No 3 3 1 2
R:R:F76 R:R:S69 6.61 0 No No 3 4 1 2
R:R:F82 R:R:T86 5.19 15 No No 2 3 1 2
R:R:F82 R:R:I152 8.79 15 No No 2 3 1 2
R:R:I152 R:R:T86 4.56 15 No No 3 3 2 2
R:R:N93 R:R:W89 9.04 0 No Yes 8 4 2 1
R:R:S183 R:R:W89 6.18 0 No Yes 7 4 2 1
R:R:F247 R:R:V180 3.93 19 Yes No 3 3 2 2
R:R:S265 R:R:V180 3.23 19 No No 4 3 1 2
R:R:F247 R:R:S265 5.28 19 Yes No 3 4 2 1
R:R:I262 R:R:Q266 4.12 0 No No 1 3 1 2
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub1.00
Average Interaction Strength11.32
Average Nodes In Shell20.00
Average Hubs In Shell3.00
Average Links In Shell21.00
Average Links Mediated by Hubs In Shell14.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of FLF in 8RQL
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:L348 A:A:L353 4.15 5 No Yes 8 7 2 1
A:A:L348 R:R:I111 9.99 5 No Yes 8 9 2 2
A:A:C351 R:R:Y107 5.38 5 No Yes 5 9 2 1
A:A:C351 R:R:I111 6.55 5 No Yes 5 9 2 2
A:A:L353 R:R:Y107 7.03 5 Yes Yes 7 9 1 1
A:A:L353 R:R:I111 4.28 5 Yes Yes 7 9 1 2
A:A:L353 W:W:?1 8.94 5 Yes Yes 7 0 1 0
R:R:V44 R:R:Y107 6.31 0 No Yes 6 9 2 1
R:R:R55 R:R:Y272 5.14 5 Yes Yes 9 5 2 2
R:R:H276 R:R:R55 12.41 5 Yes Yes 9 9 1 2
R:R:L103 R:R:Y107 11.72 0 No Yes 9 9 2 1
R:R:G104 W:W:?1 6.9 0 No Yes 8 0 1 0
R:R:I111 R:R:Y107 3.63 5 Yes Yes 9 9 2 1
R:R:Y107 W:W:?1 11.35 5 Yes Yes 9 0 1 0
R:R:I111 R:R:L201 8.56 5 Yes No 9 9 2 1
R:R:F191 R:R:F237 4.29 0 No Yes 7 6 2 1
R:R:S194 W:W:?1 6.06 0 No Yes 8 0 1 0
R:R:F237 R:R:L195 4.87 5 Yes No 6 7 1 2
R:R:F198 R:R:I202 10.05 5 Yes No 7 8 1 2
R:R:F198 R:R:V233 10.49 5 Yes Yes 7 7 1 1
R:R:F198 R:R:F237 9.65 5 Yes Yes 7 6 1 1
R:R:F198 W:W:?1 21.63 5 Yes Yes 7 0 1 0
R:R:L201 W:W:?1 5.59 0 No Yes 9 0 1 0
R:R:V230 W:W:?1 4.81 0 No Yes 7 0 1 0
R:R:S232 R:R:V233 3.23 0 No Yes 7 7 2 1
R:R:F237 R:R:V233 7.87 5 Yes Yes 6 7 1 1
R:R:V233 W:W:?1 4.81 5 Yes Yes 7 0 1 0
R:R:F236 R:R:F237 5.36 5 Yes Yes 9 6 2 1
R:R:F236 R:R:Y272 4.13 5 Yes Yes 9 5 2 2
R:R:F236 R:R:H276 9.05 5 Yes Yes 9 9 2 1
R:R:F236 R:R:V279 5.24 5 Yes No 9 7 2 2
R:R:F237 W:W:?1 10.81 5 Yes Yes 6 0 1 0
R:R:H276 R:R:Y272 9.8 5 Yes Yes 9 5 1 2
R:R:H276 R:R:V279 4.15 5 Yes No 9 7 1 2
R:R:H276 R:R:L280 11.57 5 Yes No 9 9 1 2
R:R:H276 W:W:?1 7.26 5 Yes Yes 9 0 1 0
R:R:F198 R:R:I234 2.51 5 Yes No 7 5 1 2
R:R:H227 R:R:V230 1.38 0 No No 9 7 2 1
R:R:F198 R:R:L199 1.22 5 Yes No 7 4 1 2
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub6.00
Average Interaction Strength8.82
Average Nodes In Shell28.00
Average Hubs In Shell11.00
Average Links In Shell39.00
Average Links Mediated by Hubs In Shell38.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8XQR T2 Sensory Taste2 TAS2R14 Homo Sapiens - Flufenamic acid Gt3/Beta1/Gamma1 3.2 2024-07-10 10.1038/s41586-024-07569-9

A 2D representation of the interactions of FLF in 8XQR
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:C391 R:R:Y107 5.38 0 No Yes 5 9 2 1
A:A:L393 R:R:Y107 14.07 4 No Yes 7 9 1 1
A:A:L393 W:W:?1 11.17 4 No Yes 7 0 1 0
R:R:V44 R:R:Y107 3.79 0 No Yes 6 9 2 1
R:R:R55 R:R:Y272 7.2 4 Yes Yes 9 5 2 2
R:R:H276 R:R:R55 12.41 4 Yes Yes 9 9 1 2
R:R:L103 R:R:Y107 12.89 0 No Yes 9 9 2 1
R:R:L103 R:R:L280 4.15 0 No No 9 9 2 2
R:R:G104 W:W:?1 8.28 0 No Yes 8 0 1 0
R:R:Y107 W:W:?1 13.25 4 Yes Yes 9 0 1 0
R:R:S194 W:W:?1 8.48 0 No Yes 8 0 1 0
R:R:L195 R:R:L199 6.92 0 No No 7 4 2 2
R:R:F237 R:R:L195 3.65 4 No No 6 7 1 2
R:R:F198 R:R:L199 3.65 4 Yes No 7 4 1 2
R:R:F198 R:R:I202 6.28 4 Yes No 7 8 1 2
R:R:F198 R:R:V233 5.24 4 Yes No 7 7 1 2
R:R:F198 R:R:I234 3.77 4 Yes No 7 5 1 2
R:R:F198 R:R:F237 13.93 4 Yes No 7 6 1 1
R:R:F198 W:W:?1 11.8 4 Yes Yes 7 0 1 0
R:R:L201 W:W:?1 6.7 0 No Yes 9 0 1 0
R:R:F237 W:W:?1 4.92 4 No Yes 6 0 1 0
R:R:H276 R:R:Y272 25.04 4 Yes Yes 9 5 1 2
R:R:H276 R:R:L280 10.29 4 Yes No 9 9 1 2
R:R:H276 W:W:?1 7.26 4 Yes Yes 9 0 1 0
R:R:G283 W:W:?1 2.76 0 No Yes 7 0 1 0
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub3.00
Average Interaction Strength8.29
Average Nodes In Shell21.00
Average Hubs In Shell6.00
Average Links In Shell25.00
Average Links Mediated by Hubs In Shell22.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8XQS T2 Sensory Taste2 TAS2R14 Homo Sapiens Cholesterol Flufenamic acid Gi1/Beta1/Gamma1 3.3 2024-07-10 10.1038/s41586-024-07569-9

A 2D representation of the interactions of FLF in 8XQS
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
A:A:L348 A:A:L353 5.54 0 No No 8 8 2 1
A:A:C351 R:R:Y107 5.38 0 No Yes 4 9 2 1
A:A:L353 R:R:Y107 3.52 2 No Yes 8 9 1 1
A:A:L353 W:W:?1 13.41 2 No Yes 8 0 1 0
R:R:V44 R:R:Y107 3.79 0 No Yes 6 9 2 1
R:R:H276 R:R:R55 5.64 2 Yes Yes 9 9 1 2
R:R:L103 R:R:Y107 4.69 2 Yes Yes 9 9 2 1
R:R:L103 R:R:L280 4.15 2 Yes No 9 9 2 2
R:R:G104 W:W:?1 5.52 0 No Yes 8 0 1 0
R:R:Y107 W:W:?1 15.14 2 Yes Yes 9 0 1 0
R:R:F237 R:R:S194 3.96 2 No No 6 8 1 1
R:R:S194 W:W:?1 6.06 2 No Yes 8 0 1 0
R:R:F237 R:R:L195 7.31 2 No No 6 7 1 2
R:R:F198 R:R:I202 8.79 2 Yes No 7 8 1 1
R:R:F198 R:R:V233 7.87 2 Yes No 7 7 1 2
R:R:F198 R:R:I234 3.77 2 Yes No 7 5 1 2
R:R:F198 W:W:?1 23.59 2 Yes Yes 7 0 1 0
R:R:I202 W:W:?1 4.61 2 No Yes 8 0 1 0
R:R:V230 W:W:?1 3.61 0 No Yes 7 0 1 0
R:R:F236 R:R:Y272 4.13 2 Yes Yes 9 5 2 2
R:R:F236 R:R:H276 6.79 2 Yes Yes 9 9 2 1
R:R:F237 W:W:?1 8.85 2 No Yes 6 0 1 0
R:R:H276 R:R:Y272 25.04 2 Yes Yes 9 5 1 2
R:R:H276 R:R:L280 3.86 2 Yes No 9 9 1 2
R:R:H276 W:W:?1 8.3 2 Yes Yes 9 0 1 0
R:R:G283 W:W:?1 1.38 0 No Yes 7 0 1 0
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub3.00
Average Interaction Strength9.05
Average Nodes In Shell22.00
Average Hubs In Shell8.00
Average Links In Shell26.00
Average Links Mediated by Hubs In Shell23.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links9.25
Average Number Of Links With An Hub3.25
Average Interaction Strength9.37
Average Nodes In Shell22.75
Average Hubs In Shell7.00
Average Links In Shell27.75
Average Links Mediated by Hubs In Shell24.25

missing image


Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)