psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:S65	6.06	Yes	No	0	0	4
2	L:L:?1	R:R:F76	21.63	Yes	No	0	0	3
3	L:L:?1	R:R:F82	11.8	Yes	No	0	0	2
4	L:L:?1	R:R:W89	17.47	Yes	Yes	0	0	4
5	L:L:?1	R:R:F172	14.75	Yes	No	0	0	3
6	L:L:?1	R:R:I262	10.37	Yes	No	0	0	1
7	L:L:?1	R:R:S265	4.85	Yes	No	0	0	4
8	R:R:F9	R:R:I5	8.79	No	No	0	4	4
9	R:R:I5	R:R:N260	5.66	No	No	0	4	5
10	R:R:K6	R:R:N260	8.39	No	No	0	4	5
11	R:R:F9	R:R:I263	6.28	No	No	0	4	4
12	R:R:F9	R:R:L264	8.53	No	No	0	4	4
13	R:R:F11	R:R:V15	7.87	No	No	0	5	5
14	R:R:L13	R:R:W66	7.97	No	Yes	0	4	4
15	R:R:L13	R:R:M270	4.24	No	Yes	0	4	4
16	R:R:E16	R:R:V267	5.7	Yes	No	0	8	4
17	R:R:E16	R:R:M270	5.41	Yes	Yes	0	8	4
18	R:R:A271	R:R:E16	4.53	No	Yes	0	6	8
19	R:R:F17	R:R:N21	19.33	Yes	No	0	5	6
20	R:R:F17	R:R:V59	3.93	Yes	No	4	5	7
21	R:R:F17	R:R:W60	10.02	Yes	No	0	5	3
22	R:R:F17	R:R:F63	40.73	Yes	No	0	5	4
23	R:R:F17	R:R:M270	3.73	Yes	Yes	4	5	4
24	R:R:N24	R:R:R55	6.03	No	Yes	0	9	9
25	R:R:N24	R:R:S277	8.94	No	No	0	9	9
26	R:R:F26	R:R:V30	6.55	Yes	No	0	8	8
27	R:R:F26	R:R:I281	6.28	Yes	No	0	8	9
28	R:R:F26	R:R:S291	3.96	Yes	No	0	8	5
29	R:R:I27	R:R:I281	5.89	No	No	0	9	9
30	R:R:I27	R:R:L287	7.14	No	No	0	9	9
31	R:R:L287	R:R:V30	4.47	No	No	0	9	8
32	R:R:A290	R:R:V30	5.09	No	No	0	5	8
33	R:R:D45	R:R:N31	8.08	Yes	No	0	8	8
34	R:R:N31	R:R:T49	8.77	No	No	0	8	6
35	R:R:D34	R:R:I33	4.2	Yes	No	0	6	4
36	R:R:D34	R:R:R39	25.01	Yes	No	0	6	6
37	R:R:D34	R:R:I41	4.2	Yes	Yes	0	6	6
38	R:R:D34	R:R:K286	6.91	Yes	No	0	6	8
39	R:R:I41	R:R:W35	7.05	Yes	No	5	6	5
40	R:R:R46	R:R:W35	4	No	No	5	5	5
41	R:R:D45	R:R:I41	4.2	Yes	Yes	0	8	6
42	R:R:I41	R:R:R46	12.53	Yes	No	5	6	5
43	R:R:K127	R:R:S43	9.18	No	No	0	7	6
44	R:R:V44	R:R:Y107	6.31	No	No	0	6	9
45	R:R:D45	R:R:N284	5.39	Yes	No	0	8	9
46	R:R:D45	R:R:K286	11.06	Yes	No	0	8	8
47	R:R:I47	R:R:L103	5.71	No	No	0	9	9
48	R:R:F106	R:R:I47	3.77	Yes	No	0	7	9
49	R:R:L280	R:R:L48	5.54	No	No	0	9	8
50	R:R:L48	R:R:N284	4.12	No	No	0	8	9
51	R:R:L51	R:R:R55	14.58	No	Yes	0	9	9
52	R:R:I53	R:R:I56	4.42	No	No	0	6	6
53	R:R:S54	R:R:S96	4.89	No	No	0	9	7
54	R:R:R55	R:R:S96	6.59	Yes	No	0	9	7
55	R:R:R55	R:R:Y272	5.14	Yes	Yes	1	9	5
56	R:R:P273	R:R:R55	5.76	No	Yes	0	8	9
57	R:R:H276	R:R:R55	12.41	Yes	Yes	1	9	9
58	R:R:I62	R:R:L58	4.28	No	No	0	4	4
59	R:R:L58	R:R:P273	4.93	No	No	0	4	8
60	R:R:M270	R:R:V59	7.61	Yes	No	4	4	7
61	R:R:I88	R:R:L61	4.28	No	No	0	3	4
62	R:R:I62	R:R:W89	4.7	No	Yes	0	4	4
63	R:R:I62	R:R:M270	7.29	No	Yes	0	4	4
64	R:R:F63	R:R:W66	6.01	No	Yes	0	4	4
65	R:R:C67	R:R:F63	4.19	No	No	0	4	4
66	R:R:V70	R:R:W66	6.13	No	Yes	0	4	4
67	R:R:Q266	R:R:W66	4.38	No	Yes	0	3	4
68	R:R:C67	R:R:F71	4.19	No	No	0	4	4
69	R:R:F72	R:R:V68	11.8	No	No	0	4	3
70	R:R:F76	R:R:V68	9.18	No	No	0	3	3
71	R:R:M81	R:R:V68	4.56	Yes	No	0	3	3
72	R:R:F76	R:R:S69	6.61	No	No	0	3	4
73	R:R:F72	R:R:L75	3.65	No	No	0	4	2
74	R:R:L75	R:R:M81	5.65	No	Yes	0	2	3
75	R:R:E79	R:R:I156	13.66	No	No	0	2	3
76	R:R:E79	R:R:N171	7.89	No	No	0	2	4
77	R:R:L85	R:R:M81	7.07	No	Yes	0	2	3
78	R:R:F82	R:R:T86	5.19	No	No	3	2	3
79	R:R:F82	R:R:I152	8.79	No	No	3	2	3
80	R:R:N87	R:R:R83	4.82	No	No	0	4	3
81	R:R:I152	R:R:R83	5.01	No	No	0	3	3
82	R:R:L85	R:R:M84	5.65	No	No	0	2	3
83	R:R:I152	R:R:T86	4.56	No	No	3	3	3
84	R:R:I179	R:R:T86	4.56	No	No	0	3	3
85	R:R:N149	R:R:N87	12.26	No	No	0	4	4
86	R:R:N93	R:R:W89	9.04	No	Yes	0	8	4
87	R:R:S183	R:R:W89	6.18	No	Yes	0	7	4
88	R:R:N144	R:R:T90	5.85	No	No	0	5	5
89	R:R:N93	R:R:V97	4.43	No	No	0	8	5
90	R:R:I187	R:R:N93	8.5	No	No	0	5	8
91	R:R:F95	R:R:H94	4.53	No	Yes	2	6	5
92	R:R:H94	R:R:W98	13.75	Yes	Yes	2	5	9
93	R:R:H94	R:R:T137	5.48	Yes	No	2	5	8
94	R:R:H94	R:R:L141	19.28	Yes	No	2	5	8
95	R:R:F95	R:R:L141	3.65	No	No	2	6	8
96	R:R:P190	R:R:V97	7.07	No	No	0	9	5
97	R:R:T101	R:R:W98	7.28	No	Yes	0	8	9
98	R:R:L133	R:R:W98	5.69	No	Yes	0	7	9
99	R:R:T137	R:R:W98	26.68	No	Yes	2	8	9
100	R:R:P190	R:R:W98	18.92	No	Yes	0	9	9
101	R:R:L134	R:R:L99	4.15	No	No	0	8	5
102	R:R:A100	R:R:Y272	4	No	Yes	0	8	5
103	R:R:L193	R:R:T101	4.42	No	No	0	5	8
104	R:R:G102	R:R:T105	5.46	No	No	0	5	7
105	R:R:L103	R:R:Y107	11.72	No	No	0	9	9
106	R:R:G104	W:W:?1	6.9	No	Yes	0	8	0
107	R:R:M197	R:R:T105	6.02	No	No	0	8	7
108	R:R:F106	R:R:K110	11.17	Yes	No	0	7	9
109	R:R:F106	R:R:V126	3.93	Yes	No	6	7	7
110	R:R:F106	R:R:K127	3.72	Yes	No	6	7	7
111	R:R:Y107	W:W:?1	11.35	No	Yes	0	9	0
112	R:R:F108	R:R:F114	4.29	Yes	Yes	8	8	8
113	R:R:F108	R:R:F119	5.36	Yes	Yes	8	8	9
114	R:R:F108	R:R:M197	12.44	Yes	No	0	8	8
115	R:R:F108	R:R:L200	6.09	Yes	No	0	8	7
116	R:R:L109	R:R:V126	7.45	No	No	0	7	7
117	R:R:I111	R:R:L201	8.56	No	No	0	9	9
118	R:R:A112	R:R:F119	4.16	No	Yes	0	8	9
119	R:R:F114	R:R:F119	5.36	Yes	Yes	8	8	9
120	R:R:I118	R:R:N116	5.66	No	No	0	4	8
121	R:R:F119	R:R:K123	7.44	Yes	No	0	9	9
122	R:R:R125	R:R:Y121	16.46	Yes	No	0	8	5
123	R:R:R125	R:R:W124	6	Yes	No	0	8	4
124	R:R:K127	R:R:V126	4.55	No	No	6	7	7
125	R:R:K128	R:R:L131	11.28	No	No	0	6	6
126	R:R:K128	R:R:V132	4.55	No	No	0	6	3
127	R:R:F142	R:R:S138	3.96	No	No	0	3	6
128	R:R:I145	R:R:L141	4.28	No	No	0	6	8
129	R:R:F186	R:R:L143	3.65	No	No	0	4	3
130	R:R:I148	R:R:N144	5.66	No	No	0	4	5
131	R:R:F186	R:R:N144	16.92	No	No	0	4	5
132	R:R:I145	R:R:N149	4.25	No	No	0	6	4
133	R:R:I148	R:R:N149	4.25	No	No	0	4	4
134	R:R:H151	R:R:L178	9	No	No	0	2	3
135	R:R:H151	R:R:T182	9.58	No	No	0	2	6
136	R:R:N153	R:R:N157	10.9	No	No	0	3	1
137	R:R:F175	R:R:S155	3.96	No	No	0	2	3
138	R:R:I156	R:R:N157	5.66	No	No	0	3	1
139	R:R:F247	R:R:V180	3.93	Yes	No	9	3	3
140	R:R:V180	R:R:V251	4.81	No	Yes	9	3	3
141	R:R:F248	R:R:L181	9.74	No	No	0	4	2
142	R:R:L181	R:R:W252	4.56	No	No	0	2	3
143	R:R:F188	R:R:T184	6.49	No	No	0	3	5
144	R:R:F248	R:R:T184	3.89	No	No	0	4	5
145	R:R:F186	R:R:V185	7.87	No	No	0	4	6
146	R:R:F188	R:R:S244	6.61	No	No	0	3	5
147	R:R:F191	R:R:F237	4.29	No	Yes	0	7	6
148	R:R:F191	R:R:Y240	13.41	No	No	0	7	8
149	R:R:S194	W:W:?1	6.06	No	Yes	0	8	0
150	R:R:F237	R:R:L195	4.87	Yes	No	0	6	7
151	R:R:F198	R:R:I202	10.05	Yes	No	0	7	8
152	R:R:F198	R:R:V233	10.49	Yes	Yes	1	7	7
153	R:R:F198	R:R:F237	9.65	Yes	Yes	1	7	6
154	R:R:F198	W:W:?1	21.63	Yes	Yes	1	7	0
155	R:R:L201	W:W:?1	5.59	No	Yes	0	9	0
156	R:R:F203	R:R:K207	3.72	No	No	0	5	7
157	R:R:K210	R:R:W206	6.96	No	No	0	6	4
158	R:R:K207	R:R:K210	8.62	No	No	0	7	6
159	R:R:H208	R:R:K211	6.55	No	No	10	9	5
160	R:R:H208	R:R:M212	7.88	No	No	10	9	9
161	R:R:K211	R:R:M212	5.76	No	No	10	5	9
162	R:R:H214	R:R:Q213	23.49	No	No	0	5	6
163	R:R:G229	R:R:S232	3.71	No	No	0	9	7
164	R:R:V230	W:W:?1	4.81	No	Yes	0	7	0
165	R:R:K231	R:R:T235	7.51	No	No	0	7	7
166	R:R:F237	R:R:V233	7.87	Yes	Yes	1	6	7
167	R:R:V233	W:W:?1	4.81	Yes	Yes	1	7	0
168	R:R:F236	R:R:F237	5.36	Yes	Yes	1	9	6
169	R:R:F236	R:R:Y272	4.13	Yes	Yes	1	9	5
170	R:R:C275	R:R:F236	4.19	No	Yes	0	4	9
171	R:R:F236	R:R:H276	9.05	Yes	Yes	1	9	9
172	R:R:F236	R:R:V279	5.24	Yes	No	1	9	7
173	R:R:F237	W:W:?1	10.81	Yes	Yes	1	6	0
174	R:R:Y240	R:R:Y272	14.89	No	Yes	0	8	5
175	R:R:F247	R:R:V251	7.87	Yes	Yes	9	3	3
176	R:R:F247	R:R:L264	3.65	Yes	No	0	3	4
177	R:R:F247	R:R:S265	5.28	Yes	No	0	3	4
178	R:R:I262	R:R:Q266	4.12	No	No	0	1	3
179	R:R:H276	R:R:Y272	9.8	Yes	Yes	1	9	5
180	R:R:H276	R:R:V279	4.15	Yes	No	1	9	7
181	R:R:H276	R:R:L280	11.57	Yes	No	0	9	9
182	R:R:H276	W:W:?1	7.26	Yes	Yes	1	9	0
183	R:R:L282	R:R:R288	4.86	No	No	0	6	8
184	R:R:L287	R:R:N284	5.49	No	No	0	9	9
185	R:R:K285	R:R:R288	3.71	No	No	0	6	8
186	R:R:S293	R:R:W297	8.65	No	No	0	6	3
187	R:R:L296	R:R:R299	8.5	No	No	0	3	7
188	L:L:?1	R:R:S176	3.64	Yes	No	0	0	4
189	R:R:T10	R:R:W66	3.64	No	Yes	0	5	4
190	R:R:G20	R:R:I19	3.53	No	No	0	9	5
191	R:R:G269	R:R:M268	3.49	No	No	0	4	5
192	R:R:L61	R:R:W89	3.42	No	Yes	0	4	4
193	R:R:I189	R:R:P190	3.39	No	No	0	6	9
194	R:R:A52	R:R:I27	3.25	No	No	0	8	9
195	R:R:A28	R:R:I53	3.25	No	No	0	7	6
196	R:R:S42	R:R:V44	3.23	No	No	0	8	6
197	R:R:S232	R:R:V233	3.23	No	Yes	0	7	7
198	R:R:F114	R:R:F203	3.22	Yes	No	0	8	5
199	R:R:V12	R:R:V267	3.21	No	No	0	6	4
200	R:R:I19	R:R:V15	3.07	No	No	0	5	5
201	R:R:I53	R:R:T49	3.04	No	No	0	6	6
202	R:R:M212	R:R:T215	3.01	No	No	0	9	6
203	R:R:L292	R:R:S291	3	No	No	0	5	5
204	R:R:L122	R:R:V129	2.98	No	No	0	8	6
205	R:R:L261	R:R:V251	2.98	No	Yes	0	1	3
206	R:R:L298	R:R:V294	2.98	No	No	0	5	5
207	R:R:L133	R:R:T105	2.95	No	No	0	7	7
208	R:R:L134	R:R:T137	2.95	No	No	0	8	8
209	R:R:I88	R:R:I92	2.94	No	No	7	3	4
210	R:R:I111	R:R:M205	2.92	No	No	0	9	9
211	R:R:E16	R:R:S274	2.87	Yes	No	0	8	7
212	R:R:I234	R:R:L238	2.85	No	No	0	5	5
213	R:R:I281	R:R:L282	2.85	No	No	0	9	6
214	R:R:L109	R:R:L122	2.77	No	No	0	7	8
215	R:R:L143	R:R:L147	2.77	No	No	0	3	4
216	R:R:A241	R:R:F191	2.77	No	No	0	6	7
217	R:R:F114	R:R:S204	2.64	Yes	No	0	8	9
218	R:R:F140	R:R:V136	2.62	No	No	0	3	6
219	R:R:F198	R:R:I234	2.51	Yes	No	0	7	5
220	R:R:K225	R:R:R288	2.48	No	No	0	6	8
221	R:R:V294	R:R:W297	2.45	No	No	0	5	3
222	R:R:F175	R:R:L178	2.44	No	No	0	2	3
223	R:R:F188	R:R:L245	2.44	No	No	0	3	4
224	R:R:F119	R:R:N116	2.42	Yes	No	0	9	8
225	R:R:M268	R:R:Y240	2.39	No	No	0	5	8
226	R:R:I14	R:R:W66	2.35	No	Yes	0	4	4
227	R:R:C67	R:R:G64	1.96	No	No	0	4	3
228	R:R:G20	R:R:S274	1.86	No	No	0	9	7
229	R:R:G23	R:R:S277	1.86	No	No	0	7	9
230	R:R:G102	R:R:V130	1.84	No	No	0	5	7
231	R:R:G3	R:R:K6	1.74	No	No	0	4	4
232	R:R:C278	R:R:S277	1.72	No	No	0	5	9
233	R:R:G23	R:R:L22	1.71	No	No	0	7	4
234	R:R:A226	R:R:S223	1.71	No	No	0	8	8
235	R:R:C32	R:R:T49	1.69	No	No	0	4	6
236	R:R:S250	R:R:V251	1.62	No	Yes	0	3	3
237	R:R:A50	R:R:L99	1.58	No	No	0	6	5
238	R:R:I8	R:R:S7	1.55	No	No	0	6	3
239	R:R:I56	R:R:S25	1.55	No	No	0	6	5
240	R:R:I56	R:R:S57	1.55	No	No	0	6	3
241	R:R:I5	R:R:V4	1.54	No	No	0	4	4
242	R:R:I8	R:R:V4	1.54	No	No	0	6	4
243	R:R:I8	R:R:V12	1.54	No	No	0	6	6
244	R:R:I88	R:R:V91	1.54	No	No	7	3	6
245	R:R:I92	R:R:V91	1.54	No	No	7	4	6
246	R:R:M268	R:R:S244	1.53	No	No	0	5	5
247	R:R:I148	R:R:T182	1.52	No	No	0	4	6
248	R:R:I179	R:R:T182	1.52	No	No	0	3	6
249	R:R:I189	R:R:T192	1.52	No	No	0	6	4
250	R:R:M81	R:R:T78	1.51	Yes	No	0	3	4
251	R:R:K80	R:R:T78	1.5	No	No	0	3	4
252	R:R:N113	R:R:S204	1.49	No	No	0	8	9
253	R:R:N116	R:R:S117	1.49	No	No	0	8	5
254	R:R:I14	R:R:I18	1.47	No	No	0	4	6
255	R:R:L239	R:R:T235	1.47	No	No	0	7	7
256	R:R:F72	R:R:P73	1.44	No	No	0	4	4
257	R:R:I150	R:R:L147	1.43	No	No	0	3	4
258	R:R:I242	R:R:L238	1.43	No	No	0	5	5
259	R:R:K123	R:R:L120	1.41	No	No	0	9	7
260	R:R:H227	R:R:V230	1.38	No	No	0	9	7
261	R:R:L295	R:R:L298	1.38	No	No	0	7	5
262	R:R:E258	R:R:L261	1.33	No	No	0	4	1
263	R:R:F26	R:R:V294	1.31	Yes	No	0	8	5
264	R:R:R125	R:R:V129	1.31	Yes	No	0	8	6
265	R:R:E259	R:R:N260	1.31	No	No	0	4	5
266	R:R:F175	R:R:T173	1.3	No	No	0	2	3
267	R:R:F248	R:R:I249	1.26	No	No	0	4	4
268	R:R:K37	R:R:R39	1.24	No	No	0	6	6
269	R:R:K128	R:R:R125	1.24	No	Yes	0	6	8
270	R:R:F198	R:R:L199	1.22	Yes	No	0	7	4
271	R:R:T253	R:R:W252	1.21	No	No	0	4	3
272	R:R:E79	R:R:R83	1.16	No	No	0	2	3
273	R:R:L296	R:R:W297	1.14	No	No	0	3	3
274	R:R:F140	R:R:H94	1.13	No	Yes	0	3	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	11.3212	8	0	0
2	R:R:E16	4.6275	4	0	8
3	R:R:F17	15.548	5	4	5
4	R:R:F26	4.525	4	0	8
5	R:R:D34	10.08	4	0	6
6	R:R:I41	6.995	4	5	6
7	R:R:D45	7.1825	4	0	8
8	R:R:R55	8.41833	6	1	9
9	R:R:W66	5.08	6	0	4
10	R:R:M81	4.6975	4	0	3
11	R:R:W89	8.162	5	0	4
12	R:R:H94	8.834	5	2	5
13	R:R:W98	14.464	5	2	9
14	R:R:F106	5.6475	4	6	7
15	R:R:F108	7.045	4	8	8
16	R:R:F114	3.8775	4	8	8
17	R:R:F119	4.948	5	8	9
18	R:R:R125	6.2525	4	0	8
19	R:R:F198	9.25833	6	1	7
20	R:R:V233	6.6	4	1	7
21	R:R:F236	5.594	5	1	9
22	R:R:F237	7.14167	6	1	6
23	R:R:F247	5.1825	4	9	3
24	R:R:V251	4.32	4	9	3
25	R:R:M270	5.656	5	4	4
26	R:R:Y272	7.592	5	1	5
27	R:R:H276	9.04	6	1	9
28	W:W:?1	8.80222	9	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:S265	21.544	4.85	Yes	No	0	0	4
2	R:R:F247	R:R:S265	20.3498	5.28	Yes	No	0	3	4
3	R:R:F247	R:R:L264	12.2799	3.65	Yes	No	0	3	4
4	R:R:F9	R:R:L264	10.9409	8.53	No	No	0	4	4
5	L:L:?1	R:R:W89	60.9228	17.47	Yes	Yes	0	0	4
6	R:R:I62	R:R:W89	88.8359	4.7	No	Yes	0	4	4
7	R:R:I62	R:R:M270	36.544	7.29	No	Yes	0	4	4
8	R:R:E16	R:R:M270	20.6755	5.41	Yes	Yes	0	8	4
9	R:R:E16	R:R:V267	11.3028	5.7	Yes	No	0	8	4
10	R:R:I62	R:R:L58	100	4.28	No	No	0	4	4
11	R:R:L58	R:R:P273	99.8673	4.93	No	No	0	4	8
12	R:R:P273	R:R:R55	99.7226	5.76	No	Yes	0	8	9
13	R:R:H276	R:R:R55	79.6622	12.41	Yes	Yes	1	9	9
14	R:R:H276	R:R:L280	56.6888	11.57	Yes	No	0	9	9
15	R:R:L280	R:R:L48	55.6514	5.54	No	No	0	9	8
16	R:R:L48	R:R:N284	54.6019	4.12	No	No	0	8	9
17	R:R:L287	R:R:N284	28.5464	5.49	No	No	0	9	9
18	R:R:L287	R:R:V30	17.2075	4.47	No	No	0	9	8
19	R:R:F26	R:R:V30	14.4572	6.55	Yes	No	0	8	8
20	R:R:I27	R:R:L287	10.0543	7.14	No	No	0	9	9
21	R:R:D45	R:R:N284	30.0422	5.39	Yes	No	0	8	9
22	R:R:D45	R:R:N31	12.1049	8.08	Yes	No	0	8	8
23	R:R:N31	R:R:T49	10.6333	8.77	No	No	0	8	6
24	R:R:D45	R:R:I41	10.4403	4.2	Yes	Yes	0	8	6
25	R:R:H276	W:W:?1	48.082	7.26	Yes	Yes	1	9	0
26	R:R:Y107	W:W:?1	28.2087	11.35	No	Yes	0	9	0
27	R:R:L103	R:R:Y107	24.0772	11.72	No	No	0	9	9
28	R:R:I47	R:R:L103	22.6538	5.71	No	No	0	9	9
29	R:R:F106	R:R:I47	21.2002	3.77	Yes	No	0	7	9
30	R:R:R55	R:R:Y272	18.2087	5.14	Yes	Yes	1	9	5
31	L:L:?1	R:R:F76	17.6538	21.63	Yes	No	0	0	3
32	R:R:F76	R:R:V68	14.8311	9.18	No	No	0	3	3
33	L:L:?1	R:R:F82	32.0205	11.8	Yes	No	0	0	2
34	R:R:F82	R:R:I152	12.1472	8.79	No	No	3	2	3
35	R:R:I152	R:R:R83	11.4897	5.01	No	No	0	3	3
36	R:R:F82	R:R:T86	18.6912	5.19	No	No	3	2	3
37	R:R:I179	R:R:T86	17.8468	4.56	No	No	0	3	3
38	R:R:N93	R:R:W89	46.725	9.04	No	Yes	0	8	4
39	R:R:I179	R:R:T182	16.9964	1.52	No	No	0	3	6
40	R:R:I148	R:R:T182	11.6043	1.52	No	No	0	4	6
41	R:R:I148	R:R:N144	10.5066	5.66	No	No	0	4	5
42	R:R:N93	R:R:V97	44.6562	4.43	No	No	0	8	5
43	R:R:P190	R:R:V97	43.6671	7.07	No	No	0	9	5
44	R:R:P190	R:R:W98	40.9711	18.92	No	Yes	0	9	9
45	R:R:H94	R:R:W98	11.6948	13.75	Yes	Yes	2	5	9
46	R:R:L133	R:R:W98	29.8372	5.69	No	Yes	0	7	9
47	R:R:L133	R:R:T105	28.4982	2.95	No	No	0	7	7
48	R:R:M197	R:R:T105	24.5356	6.02	No	No	0	8	7
49	R:R:F106	R:R:V126	15.2232	3.93	Yes	No	6	7	7
50	R:R:F108	R:R:M197	23.1725	12.44	Yes	No	0	8	8
51	R:R:F108	R:R:F119	10.2593	5.36	Yes	Yes	8	8	9
52	R:R:L109	R:R:V126	13.8239	7.45	No	No	0	7	7
53	R:R:L109	R:R:L122	12.3884	2.77	No	No	0	7	8
54	R:R:L122	R:R:V129	10.959	2.98	No	No	0	8	6
55	R:R:Y240	R:R:Y272	18.9566	14.89	No	Yes	0	8	5
56	R:R:M268	R:R:Y240	17.8709	2.39	No	No	0	5	8
57	R:R:M268	R:R:S244	14.7587	1.53	No	No	0	5	5
58	R:R:F188	R:R:S244	13.1665	6.61	No	No	0	3	5
59	R:R:F108	R:R:F114	10.1267	4.29	Yes	Yes	8	8	8
60	R:R:F26	R:R:V294	10.5247	1.31	Yes	No	0	8	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:S65	6.06	0	Yes	No	0	4	0	1
L:L:?1	R:R:F76	21.63	0	Yes	No	0	3	0	1
L:L:?1	R:R:F82	11.8	0	Yes	No	0	2	0	1
L:L:?1	R:R:W89	17.47	0	Yes	Yes	0	4	0	1
L:L:?1	R:R:F172	14.75	0	Yes	No	0	3	0	1
L:L:?1	R:R:I262	10.37	0	Yes	No	0	1	0	1
L:L:?1	R:R:S265	4.85	0	Yes	No	0	4	0	1
R:R:I62	R:R:W89	4.7	0	No	Yes	4	4	2	1
R:R:F76	R:R:V68	9.18	0	No	No	3	3	1	2
R:R:F76	R:R:S69	6.61	0	No	No	3	4	1	2
R:R:F82	R:R:T86	5.19	3	No	No	2	3	1	2
R:R:F82	R:R:I152	8.79	3	No	No	2	3	1	2
R:R:I152	R:R:T86	4.56	3	No	No	3	3	2	2
R:R:N93	R:R:W89	9.04	0	No	Yes	8	4	2	1
R:R:S183	R:R:W89	6.18	0	No	Yes	7	4	2	1
R:R:F247	R:R:S265	5.28	9	Yes	No	3	4	2	1
R:R:I262	R:R:Q266	4.12	0	No	No	1	3	1	2
L:L:?1	R:R:S176	3.64	0	Yes	No	0	4	0	1
R:R:L61	R:R:W89	3.42	0	No	Yes	4	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:V44	R:R:Y107	6.31	0	No	No	6	9	2	1
R:R:R55	R:R:Y272	5.14	1	Yes	Yes	9	5	2	2
R:R:H276	R:R:R55	12.41	1	Yes	Yes	9	9	1	2
R:R:L103	R:R:Y107	11.72	0	No	No	9	9	2	1
R:R:G104	W:W:?1	6.9	0	No	Yes	8	0	1	0
R:R:Y107	W:W:?1	11.35	0	No	Yes	9	0	1	0
R:R:I111	R:R:L201	8.56	0	No	No	9	9	2	1
R:R:F191	R:R:F237	4.29	0	No	Yes	7	6	2	1
R:R:S194	W:W:?1	6.06	0	No	Yes	8	0	1	0
R:R:F237	R:R:L195	4.87	1	Yes	No	6	7	1	2
R:R:F198	R:R:I202	10.05	1	Yes	No	7	8	1	2
R:R:F198	R:R:V233	10.49	1	Yes	Yes	7	7	1	1
R:R:F198	R:R:F237	9.65	1	Yes	Yes	7	6	1	1
R:R:F198	W:W:?1	21.63	1	Yes	Yes	7	0	1	0
R:R:L201	W:W:?1	5.59	0	No	Yes	9	0	1	0
R:R:V230	W:W:?1	4.81	0	No	Yes	7	0	1	0
R:R:F237	R:R:V233	7.87	1	Yes	Yes	6	7	1	1
R:R:V233	W:W:?1	4.81	1	Yes	Yes	7	0	1	0
R:R:F236	R:R:F237	5.36	1	Yes	Yes	9	6	2	1
R:R:F236	R:R:Y272	4.13	1	Yes	Yes	9	5	2	2
R:R:F236	R:R:H276	9.05	1	Yes	Yes	9	9	2	1
R:R:F236	R:R:V279	5.24	1	Yes	No	9	7	2	2
R:R:F237	W:W:?1	10.81	1	Yes	Yes	6	0	1	0
R:R:H276	R:R:Y272	9.8	1	Yes	Yes	9	5	1	2
R:R:H276	R:R:V279	4.15	1	Yes	No	9	7	1	2
R:R:H276	R:R:L280	11.57	1	Yes	No	9	9	1	2
R:R:H276	W:W:?1	7.26	1	Yes	Yes	9	0	1	0
R:R:S232	R:R:V233	3.23	0	No	Yes	7	7	2	1
R:R:F198	R:R:I234	2.51	1	Yes	No	7	5	1	2
R:R:H227	R:R:V230	1.38	0	No	No	9	7	2	1
R:R:F198	R:R:L199	1.22	1	Yes	No	7	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8RQL_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.65
Number of Linked Nodes	254
Number of Links	274
Number of Hubs	28
Number of Links mediated by Hubs	116
Number of Communities	10
Number of Nodes involved in Communities	38
Number of Links involved in Communities	45

Path Summary
Number Of Nodes in MetaPath	61
Number Of Links MetaPath	60
Number of Shortest Paths	32716
Length Of Smallest Path	3
Average Path Length	13.1912
Length of Longest Path	31
Minimum Path Strength	1.275
Average Path Strength	7.05939
Maximum Path Strength	30.03
Minimum Path Correlation	0.7
Average Path Correlation	0.935234
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	53.3351
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	31.9576
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	FLF
PDB Residues	L:L:?1 W:W:?1
Environment Details	Open EMBL-EBI Page
Code	FLF
Name	Flufenamic acid
Synonyms	FLUFENAMIC ACID
Identifier
Formula	C14 H10 F3 N O2
Molecular Weight	281.23
SMILES
PubChem	3371
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	0
Total Bonds	31
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9NYV8
Sequence	>8RQL_nogp_Chain_R G V I K S I F T F V L I V E F I I G N L G N S F I A L V N C I D W V K G R K I S S V D R I L T A L A I S R I S L V W L I F G S W C V S V F F P A L F A T E K M F R M L T N I W T V I N H F S V W L A T G L G T F Y F L K I A N F S N S I F L Y L K W R V K K V V L V L L L V T S V F L F L N I A L I N I H I N A S I N G N F T R F S S L I V L T S T V F I F I P F T L S L A M F L L L I F S M W K H R K K M Q H T S T K A H R G V K S V I T F F L L Y A I F S L S F F I S V W T E E N L I I L S Q V M G M A Y P S C H S C V L I L G N K K L R Q A S L S V L L W L R Y M F K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8RQL	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Flufenamic acid	Flufenamic acid	chim(NtGi1-Gt3)/β1/γ2	3.03	2024-11-27	doi.org/10.1038/s41467-024-54157-6
	8RQL (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Flufenamic acid	Flufenamic acid		3.03	2024-11-27	doi.org/10.1038/s41467-024-54157-6
	8XQR	T2	Sensory	Taste2	TAS2R14	Homo sapiens	-	Flufenamic acid	Gt3/β1/γ1	3.2	2024-07-10	doi.org/10.1038/s41586-024-07569-9
	8XQR (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	-	Flufenamic acid		3.2	2024-07-10	doi.org/10.1038/s41586-024-07569-9
	8XQS	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Flufenamic acid	Gi1/β1/γ1	3.3	2024-07-10	doi.org/10.1038/s41586-024-07569-9
	8XQS (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Flufenamic acid		3.3	2024-07-10	doi.org/10.1038/s41586-024-07569-9
	8XQL	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A	Gt3/β1/γ1	2.99	2024-07-10	doi.org/10.1038/s41586-024-07569-9
	8XQL (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A		2.99	2024-07-10	doi.org/10.1038/s41586-024-07569-9
	8XQN	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A	Gi1/β1/γ1	3.05	2024-07-10	doi.org/10.1038/s41586-024-07569-9
	8XQN (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A		3.05	2024-07-10	doi.org/10.1038/s41586-024-07569-9
	8XQO	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A	Gi1/β1/γ1	2.77	2024-07-10	doi.org/10.1038/s41586-024-07569-9
	8XQO (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A		2.77	2024-07-10	doi.org/10.1038/s41586-024-07569-9
	8XQP	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A	Gt3/β1/γ1	3.29	2024-07-10	doi.org/10.1038/s41586-024-07569-9
	8XQP (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A		3.29	2024-07-10	doi.org/10.1038/s41586-024-07569-9
	8XQT	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	-	Gi1/β1/γ1	2.94	2024-07-10	doi.org/10.1038/s41586-024-07569-9
	8XQT (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	-		2.94	2024-07-10	doi.org/10.1038/s41586-024-07569-9

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8RQL_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.