Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:D45 5.975408
2R:R:R55 7.894509
3R:R:W66 7.325604
4R:R:F82 7.236522
5R:R:W89 14.088504
6R:R:I92 4.095474
7R:R:H94 11.2175435
8R:R:W98 11.9117639
9R:R:L103 4.675419
10R:R:T105 5.065407
11R:R:F106 5.45407
12R:R:F108 5.83333658
13R:R:F114 6.49558
14R:R:F119 5.966559
15R:R:I148 4.735404
16R:R:H151 7.1402
17R:R:F175 7.3425422
18R:R:P190 8.875439
19R:R:F198 11.005417
20R:R:F236 5.514519
21R:R:F237 5.8775416
22R:R:F247 9.43403
23R:R:N260 10.9275465
24R:R:Q266 5.915423
25R:R:M268 11.1575425
26R:R:M270 8.8475404
27R:R:Y272 12.8025415
28R:R:S274 4.255407
29R:R:H276 8.83667619
30R:R:N284 4.49409
31W:W:?1 8.56222910
32L:L:?2 11.32131520
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:F247 R:R:S265 16.99685.28YesNo034
2L:L:?2 R:R:S265 18.167314.97YesNo204
3L:L:?2 R:R:Q266 21.06256.64YesYes203
4R:R:I263 R:R:Q266 12.91736.86NoYes043
5R:R:I263 R:R:N260 11.30354.25NoYes045
6R:R:F247 R:R:M268 17.07323.64YesYes035
7L:L:?2 R:R:M268 19.753411.28YesYes205
8R:R:Q266 R:R:W66 21.30494.38YesYes034
9R:R:L13 R:R:W66 17.91116.83NoYes044
10R:R:L13 R:R:M270 17.32234.24NoYes044
11R:R:F63 R:R:W66 13.29137.02NoYes044
12R:R:E16 R:R:M270 10013.53NoYes084
13R:R:E16 R:R:S274 99.57068.62NoYes087
14R:R:H276 R:R:R55 24.31785.64YesYes099
15R:R:F236 R:R:H276 81.95046.79YesYes199
16R:R:C275 R:R:F236 97.21574.19NoYes049
17R:R:C275 R:R:S274 97.71443.44NoYes047
18R:R:F26 R:R:V30 12.39096.55NoNo088
19R:R:N31 R:R:V30 15.67392.96NoNo088
20R:R:D45 R:R:N31 19.09544.04YesNo088
21R:R:D45 R:R:K286 25.34988.3YesNo088
22R:R:K286 R:R:N284 38.77964.2NoYes089
23R:R:L48 R:R:N284 48.77414.12NoYes089
24R:R:L280 R:R:L48 46.48154.15NoNo198
25R:R:H276 R:R:L280 60.0363.86YesNo199
26R:R:D34 R:R:K286 14.15026.91NoNo068
27R:R:D34 R:R:R39 12.598715.48NoNo066
28R:R:K37 R:R:R39 10.83953.71NoNo066
29R:R:L103 R:R:L280 12.3844.15YesNo199
30R:R:I47 R:R:L103 12.92425.71NoYes099
31R:R:H276 W:W:?1 15.43848.3YesYes190
32R:R:R55 R:R:S96 10.05685.27YesNo097
33R:R:F82 R:R:M81 10.04992.49YesNo023
34L:L:?2 R:R:F82 89.832415.79YesYes202
35R:R:F175 R:R:F82 80.5796.43YesYes222
36L:L:?2 R:R:W89 84.028331.8YesYes004
37R:R:F186 R:R:H94 11.01959.05NoYes345
38R:R:F186 R:R:N144 67.640922.96NoNo045
39R:R:I148 R:R:N144 68.65915.66YesNo045
40R:R:I148 R:R:T182 73.5424.56YesNo046
41R:R:H151 R:R:T182 74.31789.58YesNo026
42R:R:F175 R:R:H151 78.78513.39YesYes022
43R:R:F186 R:R:W98 55.58254.01NoYes349
44R:R:H94 R:R:L141 10.049920.57YesNo058
45R:R:L133 R:R:W98 46.94563.42NoYes079
46R:R:L133 R:R:T105 45.61574.42NoYes077
47R:R:M197 R:R:T105 32.09599.03NoYes087
48R:R:F108 R:R:M197 30.66217.46YesNo088
49R:R:T105 R:R:V129 13.05583.17YesNo076
50R:R:F108 R:R:F114 10.57634.29YesYes588
51R:R:F247 R:R:V251 21.8593.93YesNo033
52R:R:L181 R:R:V251 18.77682.98NoNo023
53R:R:L181 R:R:W252 15.68086.83NoNo023
54R:R:F26 R:R:V294 10.63173.93NoNo085
55R:R:I62 R:R:W89 83.65435.87NoYes044
56R:R:I62 R:R:M270 83.668114.58NoYes044
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:I62 R:R:W89 5.87 0 No Yes 4 4 2 1
R:R:Q266 R:R:S65 5.78 2 Yes No 3 4 1 1
L:L:?2 R:R:S65 5.99 2 Yes No 0 4 0 1
R:R:Q266 R:R:W66 4.38 2 Yes Yes 3 4 1 2
R:R:F76 R:R:V68 3.93 0 No No 3 3 1 2
R:R:F76 R:R:S69 15.85 0 No No 3 4 1 2
L:L:?2 R:R:F76 17 2 Yes No 0 3 0 1
R:R:F82 R:R:T86 5.19 2 Yes No 2 3 1 2
R:R:F82 R:R:I152 6.28 2 Yes No 2 3 1 2
R:R:F175 R:R:F82 6.43 2 Yes Yes 2 2 2 1
L:L:?2 R:R:F82 15.79 2 Yes Yes 0 2 0 1
L:L:?2 R:R:L85 9.66 2 Yes No 0 2 0 1
R:R:T90 R:R:W89 7.28 0 No Yes 5 4 2 1
R:R:N93 R:R:W89 18.08 0 No Yes 8 4 2 1
R:R:S183 R:R:W89 7.41 0 No Yes 7 4 2 1
L:L:?2 R:R:W89 31.8 2 Yes Yes 0 4 0 1
R:R:I187 R:R:N93 8.5 0 No No 5 8 1 2
R:R:F175 R:R:I152 5.02 2 Yes No 2 3 2 2
L:L:?2 R:R:F172 6.07 2 Yes No 0 3 0 1
R:R:I262 R:R:S176 6.19 2 No No 1 4 1 1
L:L:?2 R:R:S176 4.49 2 Yes No 0 4 0 1
R:R:S265 R:R:V180 6.46 2 No No 4 3 1 1
L:L:?2 R:R:V180 7.43 2 Yes No 0 3 0 1
L:L:?2 R:R:T184 8.82 2 Yes No 0 5 0 1
L:L:?2 R:R:I187 12.81 2 Yes No 0 5 0 1
R:R:F243 R:R:M268 6.22 0 No Yes 7 5 2 1
R:R:F247 R:R:S265 5.28 0 Yes No 3 4 2 1
R:R:F247 R:R:M268 23.64 0 Yes Yes 3 5 2 1
L:L:?2 R:R:I262 8.54 2 Yes No 0 1 0 1
R:R:I263 R:R:Q266 6.86 0 No Yes 4 3 2 1
L:L:?2 R:R:S265 14.97 2 Yes No 0 4 0 1
L:L:?2 R:R:Q266 6.64 2 Yes Yes 0 3 0 1
R:R:G269 R:R:M268 3.49 2 No Yes 4 5 1 1
L:L:?2 R:R:M268 11.28 2 Yes Yes 0 5 0 1
L:L:?2 R:R:G269 8.53 2 Yes No 0 4 0 1
R:R:A77 R:R:F172 2.77 0 No No 1 3 2 1
R:R:F188 R:R:T184 2.59 0 No No 3 5 2 1
R:R:F82 R:R:M81 2.49 2 Yes No 2 3 1 2
R:R:I262 R:R:T173 1.52 2 No No 1 3 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:V44 R:R:Y107 3.79 0 No No 6 9 2 1
R:R:H276 R:R:R55 5.64 1 Yes Yes 9 9 1 2
R:R:L103 R:R:Y107 4.69 1 Yes No 9 9 2 1
R:R:L103 R:R:L280 4.15 1 Yes No 9 9 2 2
R:R:G104 W:W:?1 5.52 0 No Yes 8 0 1 0
R:R:Y107 W:W:?1 15.14 0 No Yes 9 0 1 0
R:R:F237 R:R:S194 3.96 1 Yes No 6 8 1 1
R:R:S194 W:W:?1 6.06 1 No Yes 8 0 1 0
R:R:F237 R:R:L195 7.31 1 Yes No 6 7 1 2
R:R:F198 R:R:I202 8.79 1 Yes No 7 8 1 1
R:R:F198 R:R:V233 7.87 1 Yes No 7 7 1 2
R:R:F198 R:R:I234 3.77 1 Yes No 7 5 1 2
R:R:F198 W:W:?1 23.59 1 Yes Yes 7 0 1 0
R:R:I202 W:W:?1 4.61 1 No Yes 8 0 1 0
R:R:V230 W:W:?1 3.61 0 No Yes 7 0 1 0
R:R:F236 R:R:Y272 4.13 1 Yes Yes 9 5 2 2
R:R:F236 R:R:H276 6.79 1 Yes Yes 9 9 2 1
R:R:F237 R:R:H276 3.39 1 Yes Yes 6 9 1 1
R:R:F237 W:W:?1 8.85 1 Yes Yes 6 0 1 0
R:R:H276 R:R:Y272 25.04 1 Yes Yes 9 5 1 2
R:R:H276 R:R:L280 3.86 1 Yes No 9 9 1 2
R:R:H276 W:W:?1 8.3 1 Yes Yes 9 0 1 0
R:R:G283 W:W:?1 1.38 0 No Yes 7 0 1 0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8XQS_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.39
Number of Linked Nodes 244
Number of Links 267
Number of Hubs 32
Number of Links mediated by Hubs 137
Number of Communities 7
Number of Nodes involved in Communities 43
Number of Links involved in Communities 55
Path Summary
Number Of Nodes in MetaPath 57
Number Of Links MetaPath 56
Number of Shortest Paths 30479
Length Of Smallest Path 3
Average Path Length 14.1993
Length of Longest Path 38
Minimum Path Strength 1.205
Average Path Strength 7.91578
Maximum Path Strength 24.94
Minimum Path Correlation 0.7
Average Path Correlation 0.920785
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.125
Average % Of Corr. Nodes 44.1706
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 46.909
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• D2 dopamine receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • molecular function regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • catalytic activity   • adenylate cyclase activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • protein localization   • positive regulation of protein localization to cell periphery   • regulation of localization   • protein localization to cell periphery   • cellular localization   • regulation of protein localization   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • localization   • regulation of cellular localization   • regulation of protein localization to cell cortex   • cellular macromolecule localization   • macromolecule localization   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle
Gene OntologyCellular Component• midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle   • nuclear lumen   • cell periphery   • cell cortex   • cytoplasm   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • endomembrane system   • cilium   • plasma membrane bounded cell projection   • ciliary basal body   • cell projection   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation   • cation binding   • ion binding   • metal ion binding   • small molecule binding   • hydrolase activity, acting on glycosyl bonds   • alpha-sialidase activity   • hydrolase activity, hydrolyzing O-glycosyl compounds   • exo-alpha-sialidase activity   • taste receptor activity   • molecular transducer activity   • transmembrane signaling receptor activity   • signaling receptor activity   • bitter taste receptor activity   • G protein-coupled receptor activity   • carbohydrate metabolic process   • catabolic process   • oligosaccharide catabolic process   • oligosaccharide metabolic process   • carbohydrate catabolic process   • primary metabolic process   • metabolic process   • membrane lipid metabolic process   • sphingolipid catabolic process   • ceramide metabolic process   • ganglioside catabolic process   • carbohydrate derivative catabolic process   • glycosphingolipid catabolic process   • lipid catabolic process   • glycolipid metabolic process   • glycosphingolipid metabolic process   • liposaccharide metabolic process   • carbohydrate derivative metabolic process   • sphingolipid metabolic process   • membrane lipid catabolic process   • glycolipid catabolic process   • ceramide catabolic process   • amide metabolic process   • ganglioside metabolic process   • lipid metabolic process   • detection of chemical stimulus involved in sensory perception of bitter taste   • detection of chemical stimulus involved in sensory perception of taste   • detection of stimulus   • detection of chemical stimulus   • sensory perception of bitter taste   • detection of stimulus involved in sensory perception   • detection of chemical stimulus involved in sensory perception
SCOP2Domain Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeFLF
PDB ResiduesW:W:?1
Environment DetailsOpen EMBL-EBI Page
CodeFLF
NameFlufenamic acid
SynonymsFLUFENAMIC ACID
Identifier
FormulaC14 H10 F3 N O2
Molecular Weight281.23
SMILES
PubChem3371
Formal Charge0
Total Atoms30
Total Chiral Atoms0
Total Bonds31
Total Aromatic Bonds12

CodeCLR
PDB ResiduesL:L:?2
Environment DetailsOpen EMBL-EBI Page
CodeCLR
NameCholesterol
Synonyms
  • Cholesterin
  • Cholesterol
  • Cholest-5-en-3beta-ol
  • (3β,14β,17α)-cholest-5-en-3-ol
Identifier
FormulaC27 H46 O
Molecular Weight386.654
SMILES
PubChem5997
Formal Charge0
Total Atoms74
Total Chiral Atoms8
Total Bonds77
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ9NYV8
Sequence
>8XQS_nogp_Chain_R
GGVIKSIFT FVLIVEFII GNLGNSFIA LVNCIDWVK GRKISSVDR 
ILTALAISR ISLVWLIFG SWCVSVFFP ALFATEKMF RMLTNIWTV 
INHFSVWLA TGLGTFYFL KIANFSNSI FLYLKWRVK KVVLVLLLV 
TSVFLFLNI ALINIHINA SINGFTRFS SLIVLTSTV FIFIPFTLS 
LAMFLLLIF SMWKHRKKM QHTVKSVIT FFLLYAIFS LSFFISVWT 
SERLEENLI ILSQVMGMA YPSCHSCVL ILGNKKLRQ ASLSVLLWL 
R


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8RQLT2SensoryTaste2TAS2R14Homo sapiensFlufenamic acidFlufenamic acidchim(NtGi1-Gt3)/β1/γ23.032024-11-2710.1038/s41467-024-54157-6
8RQL (No Gprot) T2SensoryTaste2TAS2R14Homo sapiensFlufenamic acidFlufenamic acid3.032024-11-2710.1038/s41467-024-54157-6
8XQTT2SensoryTaste2TAS2R14Homo sapiensCholesterolCholesterolGi1/β1/γ12.942024-07-1010.1038/s41586-024-07569-9
8XQT (No Gprot) T2SensoryTaste2TAS2R14Homo sapiensCholesterolCholesterol2.942024-07-1010.1038/s41586-024-07569-9
8XQST2SensoryTaste2TAS2R14Homo sapiensCholesterolFlufenamic acidGi1/β1/γ13.32024-07-1010.1038/s41586-024-07569-9
8XQS (No Gprot) T2SensoryTaste2TAS2R14Homo sapiensCholesterolFlufenamic acid3.32024-07-1010.1038/s41586-024-07569-9
8XQOT2SensoryTaste2TAS2R14Homo sapiensCholesterolAristolochic acid AGi1/β1/γ12.772024-07-1010.1038/s41586-024-07569-9
8XQO (No Gprot) T2SensoryTaste2TAS2R14Homo sapiensCholesterolAristolochic acid A2.772024-07-1010.1038/s41586-024-07569-9
8XQNT2SensoryTaste2TAS2R14Homo sapiensCholesterolAristolochic acid AGi1/β1/γ13.052024-07-1010.1038/s41586-024-07569-9
8XQN (No Gprot) T2SensoryTaste2TAS2R14Homo sapiensCholesterolAristolochic acid A3.052024-07-1010.1038/s41586-024-07569-9
8XQRT2SensoryTaste2TAS2R14Homo sapiens-Flufenamic acidGt3/β1/γ13.22024-07-1010.1038/s41586-024-07569-9
8XQR (No Gprot) T2SensoryTaste2TAS2R14Homo sapiens-Flufenamic acid3.22024-07-1010.1038/s41586-024-07569-9
8XQPT2SensoryTaste2TAS2R14Homo sapiensCholesterolAristolochic acid AGt3/β1/γ13.292024-07-1010.1038/s41586-024-07569-9
8XQP (No Gprot) T2SensoryTaste2TAS2R14Homo sapiensCholesterolAristolochic acid A3.292024-07-1010.1038/s41586-024-07569-9
8XQLT2SensoryTaste2TAS2R14Homo sapiensCholesterolAristolochic acid AGt3/β1/γ12.992024-07-1010.1038/s41586-024-07569-9
8XQL (No Gprot) T2SensoryTaste2TAS2R14Homo sapiensCholesterolAristolochic acid A2.992024-07-1010.1038/s41586-024-07569-9




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Download 8XQS_nogp.zip



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