psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F9	R:R:L264	8.53	No	No	0	4	4
2	R:R:T10	R:R:W66	6.06	No	Yes	0	5	4
3	R:R:F11	R:R:V15	3.93	No	No	0	5	5
4	R:R:E16	R:R:V12	4.28	Yes	No	0	8	6
5	R:R:L13	R:R:W66	13.67	No	Yes	0	4	4
6	R:R:I263	R:R:L13	7.14	No	No	0	4	4
7	R:R:L13	R:R:M270	4.24	No	Yes	0	4	4
8	R:R:E16	R:R:V267	7.13	Yes	No	0	8	4
9	R:R:E16	R:R:M270	8.12	Yes	Yes	0	8	4
10	R:R:A271	R:R:E16	4.53	No	Yes	0	6	8
11	R:R:E16	R:R:S274	7.19	Yes	No	0	8	7
12	R:R:F17	R:R:N21	18.12	Yes	No	4	5	6
13	R:R:F17	R:R:V59	3.93	Yes	No	0	5	7
14	R:R:F17	R:R:W60	9.02	Yes	No	4	5	3
15	R:R:F17	R:R:F63	37.51	Yes	Yes	4	5	4
16	R:R:I19	R:R:S274	4.64	Yes	No	0	5	7
17	R:R:N21	R:R:W60	11.3	No	No	4	6	3
18	R:R:N24	R:R:R55	6.03	No	Yes	0	9	9
19	R:R:I56	R:R:N24	7.08	No	No	0	6	9
20	R:R:N24	R:R:S277	7.45	No	No	0	9	9
21	R:R:F26	R:R:V30	7.87	Yes	No	5	8	8
22	R:R:F26	R:R:I281	5.02	Yes	No	5	8	9
23	R:R:A290	R:R:F26	4.16	No	Yes	5	5	8
24	R:R:F26	R:R:V294	3.93	Yes	No	0	8	5
25	R:R:I27	R:R:S277	4.64	Yes	No	0	9	9
26	R:R:I27	R:R:I281	5.89	Yes	No	5	9	9
27	R:R:I27	R:R:L287	9.99	Yes	No	5	9	9
28	R:R:I33	R:R:L29	4.28	No	No	0	4	5
29	R:R:A290	R:R:V30	5.09	No	No	5	5	8
30	R:R:D45	R:R:N31	4.04	Yes	No	7	8	8
31	R:R:N31	R:R:T49	5.85	No	No	0	8	6
32	R:R:K286	R:R:N31	4.2	Yes	No	7	8	8
33	R:R:C32	R:R:W35	3.92	No	No	0	4	5
34	R:R:D34	R:R:R39	19.06	No	No	0	6	6
35	R:R:D34	R:R:K286	9.68	No	Yes	0	6	8
36	R:R:V36	R:R:W35	6.13	No	No	0	5	5
37	R:R:K37	R:R:R39	4.95	No	No	0	6	6
38	R:R:D45	R:R:I41	5.6	Yes	No	0	8	6
39	R:R:I41	R:R:R46	5.01	No	No	0	6	5
40	R:R:D45	R:R:S42	8.83	Yes	No	0	8	8
41	R:R:F106	R:R:S43	9.25	Yes	No	0	7	6
42	R:R:K127	R:R:S43	4.59	No	No	0	7	6
43	R:R:V44	R:R:Y107	3.79	No	No	0	6	9
44	R:R:D45	R:R:K286	4.15	Yes	Yes	7	8	8
45	R:R:I47	R:R:L103	7.14	No	No	0	9	9
46	R:R:F106	R:R:I47	5.02	Yes	No	0	7	9
47	R:R:L280	R:R:L48	5.54	No	No	0	9	8
48	R:R:L48	R:R:N284	4.12	No	Yes	0	8	9
49	R:R:A50	R:R:L99	4.73	No	No	0	6	5
50	R:R:L51	R:R:R55	13.36	No	Yes	0	9	9
51	R:R:L51	R:R:L99	5.54	No	No	0	9	5
52	R:R:A100	R:R:L51	4.73	No	No	0	8	9
53	R:R:S54	R:R:S96	6.52	No	No	0	9	7
54	R:R:R55	R:R:S96	3.95	Yes	No	0	9	7
55	R:R:R55	R:R:Y272	15.43	Yes	Yes	3	9	5
56	R:R:P273	R:R:R55	5.76	No	Yes	0	8	9
57	R:R:H276	R:R:R55	13.54	Yes	Yes	3	9	9
58	R:R:I92	R:R:S57	4.64	No	No	0	4	3
59	R:R:L58	R:R:W89	4.56	No	Yes	1	4	4
60	R:R:I92	R:R:L58	8.56	No	No	0	4	4
61	R:R:L58	R:R:N93	5.49	No	Yes	1	4	8
62	R:R:M270	R:R:V59	4.56	Yes	No	0	4	7
63	R:R:L61	R:R:L85	4.15	No	No	0	4	2
64	R:R:I62	R:R:W89	4.7	No	Yes	0	4	4
65	R:R:I62	R:R:M270	5.83	No	Yes	0	4	4
66	R:R:F63	R:R:W66	8.02	Yes	Yes	4	4	4
67	R:R:C67	R:R:F63	4.19	No	Yes	4	4	4
68	R:R:F76	R:R:S65	3.96	Yes	No	1	3	4
69	R:R:Q266	R:R:S65	7.22	No	No	0	3	4
70	L:L:?2	R:R:S65	5.99	Yes	No	1	0	4
71	R:R:C67	R:R:W66	3.92	No	Yes	4	4	4
72	R:R:V70	R:R:W66	12.26	No	Yes	0	4	4
73	R:R:Q266	R:R:W66	4.38	No	Yes	0	3	4
74	R:R:F72	R:R:V68	9.18	No	No	0	4	3
75	R:R:L75	R:R:V68	4.47	No	No	0	2	3
76	R:R:F76	R:R:V68	5.24	Yes	No	0	3	3
77	R:R:F76	R:R:S69	15.85	Yes	No	0	3	4
78	R:R:F71	R:R:F72	6.43	No	No	0	4	4
79	R:R:L75	R:R:T78	4.42	No	No	1	2	4
80	R:R:L75	R:R:M81	5.65	No	Yes	1	2	3
81	R:R:F76	R:R:M81	4.98	Yes	Yes	1	3	3
82	L:L:?2	R:R:F76	20.65	Yes	Yes	1	0	3
83	R:R:M81	R:R:T78	4.52	Yes	No	1	3	4
84	R:R:E79	R:R:F82	5.83	No	Yes	1	2	2
85	R:R:E79	R:R:F172	17.49	No	Yes	1	2	3
86	L:L:?2	R:R:M81	5.64	Yes	Yes	1	0	3
87	R:R:F82	R:R:T86	7.78	Yes	No	0	2	3
88	R:R:F82	R:R:I152	5.02	Yes	Yes	0	2	3
89	R:R:F172	R:R:F82	5.36	Yes	Yes	1	3	2
90	L:L:?2	R:R:F82	19.43	Yes	Yes	1	0	2
91	R:R:I152	R:R:R83	13.78	Yes	Yes	0	3	3
92	R:R:N153	R:R:R83	10.85	No	Yes	0	3	3
93	R:R:I156	R:R:R83	5.01	No	Yes	0	3	3
94	L:L:?2	R:R:L85	6.9	Yes	No	0	0	2
95	R:R:I148	R:R:N87	4.25	No	No	0	4	4
96	R:R:N149	R:R:N87	10.9	No	No	0	4	4
97	R:R:N93	R:R:W89	19.21	Yes	Yes	1	8	4
98	R:R:S183	R:R:W89	4.94	No	Yes	1	7	4
99	L:L:?2	R:R:W89	38.62	Yes	Yes	1	0	4
100	R:R:N144	R:R:T90	5.85	No	No	0	5	5
101	R:R:L141	R:R:V91	4.47	No	No	0	8	6
102	R:R:N93	R:R:V97	4.43	Yes	No	0	8	5
103	R:R:I187	R:R:N93	7.08	No	Yes	0	5	8
104	R:R:H94	R:R:W98	11.64	No	Yes	8	5	9
105	R:R:H94	R:R:T137	9.58	No	Yes	8	5	8
106	R:R:H94	R:R:L141	18	No	No	0	5	8
107	R:R:V97	R:R:Y272	3.79	No	Yes	0	5	5
108	R:R:T101	R:R:W98	6.06	No	Yes	0	8	9
109	R:R:L133	R:R:W98	6.83	No	Yes	0	7	9
110	R:R:T137	R:R:W98	30.32	Yes	Yes	8	8	9
111	R:R:P190	R:R:W98	17.57	No	Yes	0	9	9
112	R:R:L193	R:R:T101	4.42	No	No	0	5	8
113	R:R:S194	R:R:T101	4.8	No	No	0	8	8
114	R:R:L103	R:R:Y107	10.55	No	No	0	9	9
115	R:R:L103	R:R:L280	4.15	No	No	0	9	9
116	R:R:G104	W:W:?1	7.44	No	Yes	0	8	0
117	R:R:L133	R:R:T105	4.42	No	Yes	0	7	7
118	R:R:M197	R:R:T105	4.52	No	Yes	0	8	7
119	R:R:F106	R:R:K110	11.17	Yes	No	0	7	9
120	R:R:F106	R:R:V126	3.93	Yes	No	0	7	7
121	R:R:Y107	W:W:?1	13.84	No	Yes	0	9	0
122	R:R:F108	R:R:L109	4.87	Yes	No	2	8	7
123	R:R:F108	R:R:F114	8.57	Yes	Yes	2	8	8
124	R:R:F108	R:R:F119	5.36	Yes	Yes	2	8	9
125	R:R:F108	R:R:M197	12.44	Yes	No	0	8	8
126	R:R:F108	R:R:L200	7.31	Yes	No	0	8	7
127	R:R:L109	R:R:L122	4.15	No	No	2	7	8
128	R:R:L109	R:R:V129	4.47	No	No	2	7	6
129	R:R:I111	R:R:L201	7.14	No	No	0	9	9
130	R:R:A112	R:R:F114	4.16	No	Yes	0	8	8
131	R:R:F114	R:R:F119	19.29	Yes	Yes	2	8	9
132	R:R:F114	R:R:F203	6.43	Yes	No	2	8	5
133	R:R:F114	R:R:S204	6.61	Yes	No	0	8	9
134	R:R:I118	R:R:N116	11.33	No	No	0	4	8
135	R:R:F119	R:R:K123	4.96	Yes	No	0	9	9
136	R:R:L120	R:R:W124	6.83	No	No	0	7	4
137	R:R:R125	R:R:Y121	19.55	No	No	0	8	5
138	R:R:L122	R:R:V129	4.47	No	No	2	8	6
139	R:R:K128	R:R:R125	11.14	No	No	0	6	8
140	R:R:F140	R:R:T137	5.19	No	Yes	0	3	8
141	R:R:F142	R:R:S138	5.28	No	No	0	3	6
142	R:R:F140	R:R:F186	4.29	No	No	0	3	4
143	R:R:F186	R:R:L143	6.09	No	No	0	4	3
144	R:R:F186	R:R:N144	15.71	No	No	0	4	5
145	R:R:H151	R:R:L147	11.57	Yes	No	0	2	4
146	R:R:I152	R:R:N149	5.66	Yes	No	0	3	4
147	R:R:H151	R:R:L178	7.71	Yes	No	0	2	3
148	R:R:H151	R:R:T182	6.85	Yes	No	0	2	6
149	R:R:F175	R:R:S155	9.25	No	No	0	2	3
150	R:R:N157	R:R:R160	9.64	No	No	0	1	5
151	R:R:F172	R:R:S176	5.28	Yes	No	0	3	4
152	L:L:?2	R:R:F172	6.07	Yes	Yes	1	0	3
153	R:R:E258	R:R:T173	7.06	No	No	0	4	3
154	R:R:F175	R:R:R174	5.34	No	No	0	2	2
155	R:R:L181	R:R:W252	5.69	No	No	0	2	3
156	L:L:?2	R:R:S183	4.49	Yes	No	1	0	7
157	R:R:F248	R:R:T184	7.78	No	No	0	4	5
158	L:L:?2	R:R:T184	5.88	Yes	No	0	0	5
159	R:R:F248	R:R:V185	3.93	No	No	0	4	6
160	L:L:?2	R:R:I187	5.69	Yes	No	0	0	5
161	R:R:F188	R:R:S244	7.93	No	No	0	3	5
162	R:R:F191	R:R:F237	10.72	No	No	0	7	6
163	R:R:F191	R:R:Y240	12.38	No	No	0	7	8
164	R:R:S194	W:W:?1	7.47	No	Yes	0	8	0
165	R:R:F237	R:R:L195	10.96	No	No	0	6	7
166	R:R:F198	R:R:I202	8.79	Yes	No	0	7	8
167	R:R:F198	R:R:V233	9.18	Yes	No	3	7	7
168	R:R:F198	R:R:I234	5.02	Yes	No	0	7	5
169	R:R:F198	W:W:?1	20.44	Yes	Yes	3	7	0
170	R:R:L201	R:R:M205	5.65	No	No	0	9	9
171	R:R:L201	W:W:?1	5.16	No	Yes	0	9	0
172	R:R:F203	R:R:W206	4.01	No	No	2	5	4
173	R:R:F203	R:R:K207	6.2	No	No	2	5	7
174	R:R:K207	R:R:W206	4.64	No	No	2	7	4
175	R:R:H208	R:R:M212	3.94	No	Yes	0	9	9
176	R:R:Q213	R:R:R209	4.67	No	Yes	6	6	6
177	R:R:K217	R:R:R209	6.19	No	Yes	6	5	6
178	R:R:D221	R:R:R209	20.25	No	Yes	6	8	6
179	R:R:R209	R:R:S223	10.54	Yes	No	0	6	8
180	R:R:R209	R:R:T224	5.17	Yes	No	0	6	7
181	R:R:H214	R:R:K210	7.86	No	No	0	5	6
182	R:R:K211	R:R:M212	5.76	No	Yes	0	5	9
183	R:R:M212	R:R:T215	6.02	Yes	No	0	9	6
184	R:R:K217	R:R:Q213	12.2	No	No	6	5	6
185	R:R:D221	R:R:K217	11.06	No	No	6	8	5
186	R:R:R228	R:R:R288	6.4	No	No	0	5	8
187	R:R:L282	R:R:S232	10.51	No	No	0	6	7
188	R:R:V233	W:W:?1	12.96	No	Yes	3	7	0
189	R:R:F236	R:R:Y272	4.13	Yes	Yes	3	9	5
190	R:R:C275	R:R:F236	4.19	No	Yes	0	4	9
191	R:R:F236	R:R:H276	10.18	Yes	Yes	3	9	9
192	R:R:F236	R:R:V279	9.18	Yes	No	0	9	7
193	R:R:F237	W:W:?1	6.06	No	Yes	0	6	0
194	R:R:F243	R:R:L239	9.74	No	No	0	7	7
195	R:R:S244	R:R:Y240	3.82	No	No	0	5	8
196	R:R:Y240	R:R:Y272	13.9	No	Yes	0	8	5
197	R:R:F243	R:R:I242	6.28	No	No	0	7	5
198	R:R:F247	R:R:V251	13.11	Yes	No	0	3	3
199	R:R:F247	R:R:L264	8.53	Yes	No	0	3	4
200	R:R:F247	R:R:S265	3.96	Yes	No	0	3	4
201	R:R:F247	R:R:M268	18.66	Yes	No	0	3	5
202	R:R:R256	R:R:S250	13.18	No	No	0	1	3
203	R:R:T253	R:R:W252	10.92	No	No	0	4	3
204	R:R:E259	R:R:L257	11.93	No	No	0	4	1
205	R:R:E258	R:R:L261	3.98	No	No	0	4	1
206	R:R:E259	R:R:N260	5.26	No	No	0	4	5
207	L:L:?2	R:R:I262	4.27	Yes	No	0	0	1
208	L:L:?2	R:R:S265	11.98	Yes	No	0	0	4
209	L:L:?2	R:R:M268	8.46	Yes	No	0	0	5
210	L:L:?2	R:R:G269	5.12	Yes	No	0	0	4
211	R:R:H276	R:R:Y272	11.98	Yes	Yes	3	9	5
212	R:R:H276	R:R:L280	5.14	Yes	No	0	9	9
213	R:R:H276	W:W:?1	13.59	Yes	Yes	3	9	0
214	R:R:I281	R:R:L287	4.28	No	No	5	9	9
215	R:R:K286	R:R:N284	4.2	Yes	Yes	0	8	9
216	R:R:L287	R:R:N284	9.61	No	Yes	0	9	9
217	R:R:K285	R:R:Q289	4.07	No	No	0	6	7
218	R:R:L292	R:R:Q289	3.99	No	No	0	5	7
219	R:R:V294	R:R:W297	4.9	No	No	0	5	3
220	R:R:L298	R:R:W297	10.25	No	No	0	5	3
221	R:R:F248	R:R:L181	3.65	No	No	0	4	2
222	R:R:G102	R:R:T105	3.64	No	Yes	0	5	7
223	R:R:L261	R:R:R256	3.64	No	No	0	1	1
224	R:R:F119	R:R:N116	3.62	Yes	No	0	9	8
225	R:R:G2	R:R:I5	3.53	No	No	0	4	4
226	R:R:G20	R:R:I19	3.53	No	Yes	0	9	5
227	R:R:I41	R:R:W35	3.52	No	No	0	6	5
228	R:R:G283	R:R:L282	3.42	No	No	0	7	6
229	R:R:I189	R:R:P190	3.39	No	No	0	6	9
230	R:R:A52	R:R:I27	3.25	No	Yes	0	8	9
231	R:R:S265	R:R:V180	3.23	No	No	0	4	3
232	R:R:S232	R:R:V233	3.23	No	No	0	7	7
233	R:R:T105	R:R:V130	3.17	Yes	No	0	7	7
234	R:R:I145	R:R:V91	3.07	No	No	0	6	6
235	R:R:I202	R:R:V230	3.07	No	No	0	8	7
236	R:R:I179	R:R:T86	3.04	No	No	0	3	3
237	R:R:K128	R:R:V129	3.04	No	No	0	6	6
238	R:R:M212	R:R:V216	3.04	Yes	No	0	9	7
239	R:R:L239	R:R:T235	2.95	No	No	0	7	7
240	R:R:I18	R:R:I19	2.94	No	Yes	0	6	5
241	R:R:I33	R:R:K37	2.91	No	No	0	4	6
242	R:R:I5	R:R:N260	2.83	No	No	0	4	5
243	R:R:L195	R:R:L199	2.77	No	No	0	7	4
244	R:R:D221	R:R:M212	2.77	No	Yes	0	8	9
245	R:R:H151	R:R:I148	2.65	Yes	No	0	2	4
246	R:R:F26	R:R:S291	2.64	Yes	No	0	8	5
247	R:R:F95	R:R:V91	2.62	No	No	0	6	6
248	R:R:F63	R:R:I14	2.51	Yes	No	0	4	4
249	R:R:M84	R:R:R83	2.48	No	Yes	0	3	3
250	R:R:F188	R:R:L245	2.44	No	No	0	3	4
251	R:R:L264	R:R:R256	2.43	No	No	0	4	1
252	R:R:L295	R:R:R299	2.43	No	No	0	7	7
253	R:R:L296	R:R:R299	2.43	No	No	0	3	7
254	R:R:G2	R:R:G3	2.11	No	No	0	4	4
255	R:R:C67	R:R:G64	1.96	No	No	0	4	3
256	R:R:G23	R:R:S277	1.86	No	No	0	7	9
257	R:R:G229	R:R:S232	1.86	No	No	0	9	7
258	R:R:A28	R:R:A52	1.79	No	No	0	7	8
259	R:R:G3	R:R:K6	1.74	No	No	0	4	4
260	R:R:G23	R:R:L22	1.71	No	No	0	7	4
261	R:R:G158	R:R:N157	1.7	No	No	0	2	1
262	R:R:C278	R:R:I19	1.64	No	Yes	0	5	5
263	R:R:S250	R:R:S254	1.63	No	No	0	3	2
264	R:R:S7	R:R:V4	1.62	No	No	0	3	4
265	R:R:V132	R:R:V136	1.6	No	No	0	3	6
266	R:R:I8	R:R:S7	1.55	No	No	0	6	3
267	R:R:I152	R:R:S155	1.55	Yes	No	0	3	3
268	R:R:I156	R:R:S155	1.55	No	No	0	3	3
269	R:R:I5	R:R:V4	1.54	No	No	0	4	4
270	R:R:I19	R:R:V15	1.54	Yes	No	0	5	5
271	R:R:K40	R:R:S42	1.53	No	No	0	6	8
272	R:R:M205	R:R:S223	1.53	No	No	0	9	8
273	R:R:K128	R:R:V132	1.52	No	No	0	6	3
274	R:R:I249	R:R:T253	1.52	No	No	0	4	4
275	R:R:K6	R:R:T10	1.5	No	No	0	4	5
276	R:R:K80	R:R:T78	1.5	No	No	0	3	4
277	R:R:L178	R:R:S177	1.5	No	No	0	3	3
278	R:R:G229	R:R:R228	1.5	No	No	0	9	5
279	R:R:K231	R:R:T235	1.5	No	No	0	7	7
280	R:R:I53	R:R:I56	1.47	No	No	0	6	6
281	R:R:L134	R:R:T137	1.47	No	Yes	0	8	8
282	R:R:I88	R:R:M84	1.46	No	No	0	3	3
283	R:R:F72	R:R:P73	1.44	No	No	0	4	4
284	R:R:I234	R:R:L238	1.43	No	No	0	5	5
285	R:R:I156	R:R:N157	1.42	No	No	0	3	1
286	R:R:K285	R:R:N284	1.4	No	Yes	0	6	9
287	R:R:A226	R:R:R228	1.38	No	No	0	8	5
288	R:R:H151	R:R:I150	1.33	Yes	No	0	2	3
289	R:R:F243	R:R:S246	1.32	No	No	0	7	5
290	R:R:F119	R:R:L120	1.22	Yes	No	0	9	7
291	R:R:F142	R:R:L141	1.22	No	No	0	3	8
292	R:R:E79	R:R:Y159	1.12	No	No	0	2	1

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:E16	6.25	5	0	8
2	R:R:F17	17.145	4	4	5
3	R:R:I19	2.858	5	0	5
4	R:R:F26	4.724	5	5	8
5	R:R:I27	5.9425	4	5	9
6	R:R:D45	5.655	4	7	8
7	R:R:R55	9.67833	6	3	9
8	R:R:F63	13.0575	4	4	4
9	R:R:W66	8.05167	6	4	4
10	R:R:F76	10.136	5	1	3
11	R:R:M81	5.1975	4	1	3
12	R:R:F82	8.684	5	1	2
13	R:R:R83	8.03	4	0	3
14	R:R:W89	14.406	5	1	4
15	R:R:N93	9.0525	4	1	8
16	R:R:W98	14.484	5	8	9
17	R:R:T105	3.9375	4	0	7
18	R:R:F106	7.3425	4	0	7
19	R:R:F108	7.71	5	2	8
20	R:R:F114	9.012	5	2	8
21	R:R:F119	6.89	5	2	9
22	R:R:T137	11.64	4	8	8
23	R:R:H151	6.022	5	0	2
24	R:R:I152	6.5025	4	0	3
25	R:R:F172	8.55	4	1	3
26	R:R:F198	10.8575	4	3	7
27	R:R:R209	9.364	5	6	6
28	R:R:M212	4.306	5	0	9
29	R:R:F236	6.92	4	3	9
30	R:R:F247	11.065	4	0	3
31	R:R:M270	5.6875	4	0	4
32	R:R:Y272	9.846	5	3	5
33	R:R:H276	10.886	5	3	9
34	R:R:N284	4.8325	4	0	9
35	R:R:K286	5.5575	4	7	8
36	W:W:?1	10.87	8	3	0
37	L:L:?2	10.6564	14	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F247	R:R:L264	18.3396	8.53	Yes	No	0	3	4
2	R:R:F247	R:R:S265	11.4528	3.96	Yes	No	0	3	4
3	L:L:?2	R:R:S265	13.3668	11.98	Yes	No	0	0	4
4	L:L:?2	R:R:S65	21.0419	5.99	Yes	No	1	0	4
5	R:R:Q266	R:R:S65	20.8915	7.22	No	No	0	3	4
6	R:R:Q266	R:R:W66	20.0418	4.38	No	Yes	0	3	4
7	R:R:T10	R:R:W66	17.71	6.06	No	Yes	0	5	4
8	R:R:F247	R:R:M268	11.425	18.66	Yes	No	0	3	5
9	L:L:?2	R:R:M268	12.4836	8.46	Yes	No	0	0	5
10	R:R:I62	R:R:M270	20.2062	5.83	No	Yes	0	4	4
11	R:R:I62	R:R:W89	20.6686	4.7	No	Yes	0	4	4
12	L:L:?2	R:R:W89	45.9702	38.62	Yes	Yes	1	0	4
13	R:R:N93	R:R:W89	57.7295	19.21	Yes	Yes	1	8	4
14	R:R:N93	R:R:V97	100	4.43	Yes	No	0	8	5
15	R:R:V97	R:R:Y272	99.7465	3.79	No	Yes	0	5	5
16	R:R:R55	R:R:Y272	17.8688	15.43	Yes	Yes	3	9	5
17	R:R:N24	R:R:R55	16.7154	6.03	No	Yes	0	9	9
18	L:L:?2	R:R:I187	41.1701	5.69	Yes	No	0	0	5
19	R:R:I187	R:R:N93	41.3651	7.08	No	Yes	0	5	8
20	R:R:N24	R:R:S277	14.0577	7.45	No	No	0	9	9
21	R:R:I27	R:R:S277	11.3665	4.64	Yes	No	0	9	9
22	R:R:H276	R:R:Y272	76.0217	11.98	Yes	Yes	3	9	5
23	R:R:H276	R:R:L280	28.3911	5.14	Yes	No	0	9	9
24	R:R:L280	R:R:L48	23.3097	5.54	No	No	0	9	8
25	R:R:L48	R:R:N284	22.4126	4.12	No	Yes	0	8	9
26	R:R:K286	R:R:N284	16.3811	4.2	Yes	Yes	0	8	9
27	R:R:H276	W:W:?1	68.1098	13.59	Yes	Yes	3	9	0
28	L:L:?2	R:R:F82	32.96	19.43	Yes	Yes	1	0	2
29	R:R:F82	R:R:I152	28.2045	5.02	Yes	Yes	0	2	3
30	R:R:I152	R:R:N149	10.553	5.66	Yes	No	0	3	4
31	R:R:S194	W:W:?1	45.6108	7.47	No	Yes	0	8	0
32	R:R:S194	R:R:T101	44.7555	4.8	No	No	0	8	8
33	R:R:T101	R:R:W98	43.0283	6.06	No	Yes	0	8	9
34	R:R:L133	R:R:W98	27.4439	6.83	No	Yes	0	7	9
35	R:R:L133	R:R:T105	26.5636	4.42	No	Yes	0	7	7
36	R:R:M197	R:R:T105	23.6189	4.52	No	Yes	0	8	7
37	R:R:F108	R:R:M197	22.6299	12.44	Yes	No	0	8	8
38	R:R:L201	W:W:?1	14.8294	5.16	No	Yes	0	9	0
39	R:R:L264	R:R:R256	13.7874	2.43	No	No	0	4	1
40	R:R:L201	R:R:M205	12.9684	5.65	No	No	0	9	9
41	R:R:M205	R:R:S223	11.9181	1.53	No	No	0	9	8
42	R:R:R209	R:R:S223	10.8567	10.54	Yes	No	0	6	8
43	R:R:G2	R:R:I5	11.347	3.53	No	No	0	4	4
44	R:R:G2	R:R:G3	12.9461	2.11	No	No	0	4	4
45	R:R:G3	R:R:K6	14.5396	1.74	No	No	0	4	4
46	R:R:K6	R:R:T10	16.1276	1.5	No	No	0	4	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L58	R:R:W89	4.56	1	No	Yes	4	4	2	1
R:R:L58	R:R:N93	5.49	1	No	Yes	4	8	2	2
R:R:L61	R:R:L85	4.15	0	No	No	4	2	2	1
R:R:I62	R:R:W89	4.7	0	No	Yes	4	4	2	1
R:R:F76	R:R:S65	3.96	1	Yes	No	3	4	1	1
R:R:Q266	R:R:S65	7.22	0	No	No	3	4	2	1
L:L:?2	R:R:S65	5.99	1	Yes	No	0	4	0	1
R:R:L75	R:R:V68	4.47	1	No	No	2	3	2	2
R:R:F76	R:R:V68	5.24	1	Yes	No	3	3	1	2
R:R:F76	R:R:S69	15.85	1	Yes	No	3	4	1	2
R:R:L75	R:R:T78	4.42	1	No	No	2	4	2	2
R:R:L75	R:R:M81	5.65	1	No	Yes	2	3	2	1
R:R:F76	R:R:M81	4.98	1	Yes	Yes	3	3	1	1
L:L:?2	R:R:F76	20.65	1	Yes	Yes	0	3	0	1
R:R:M81	R:R:T78	4.52	1	Yes	No	3	4	1	2
R:R:E79	R:R:F82	5.83	1	No	Yes	2	2	2	1
R:R:E79	R:R:F172	17.49	1	No	Yes	2	3	2	1
L:L:?2	R:R:M81	5.64	1	Yes	Yes	0	3	0	1
R:R:F82	R:R:T86	7.78	1	Yes	No	2	3	1	2
R:R:F82	R:R:I152	5.02	1	Yes	Yes	2	3	1	2
R:R:F172	R:R:F82	5.36	1	Yes	Yes	3	2	1	1
L:L:?2	R:R:F82	19.43	1	Yes	Yes	0	2	0	1
L:L:?2	R:R:L85	6.9	1	Yes	No	0	2	0	1
R:R:N93	R:R:W89	19.21	1	Yes	Yes	8	4	2	1
R:R:S183	R:R:W89	4.94	1	No	Yes	7	4	1	1
L:L:?2	R:R:W89	38.62	1	Yes	Yes	0	4	0	1
R:R:I187	R:R:N93	7.08	0	No	Yes	5	8	1	2
R:R:F172	R:R:S176	5.28	1	Yes	No	3	4	1	2
L:L:?2	R:R:F172	6.07	1	Yes	Yes	0	3	0	1
L:L:?2	R:R:S183	4.49	1	Yes	No	0	7	0	1
R:R:F248	R:R:T184	7.78	0	No	No	4	5	2	1
L:L:?2	R:R:T184	5.88	1	Yes	No	0	5	0	1
L:L:?2	R:R:I187	5.69	1	Yes	No	0	5	0	1
R:R:F247	R:R:S265	3.96	0	Yes	No	3	4	2	1
R:R:F247	R:R:M268	18.66	0	Yes	No	3	5	2	1
L:L:?2	R:R:I262	4.27	1	Yes	No	0	1	0	1
L:L:?2	R:R:S265	11.98	1	Yes	No	0	4	0	1
L:L:?2	R:R:M268	8.46	1	Yes	No	0	5	0	1
L:L:?2	R:R:G269	5.12	1	Yes	No	0	4	0	1
R:R:S265	R:R:V180	3.23	0	No	No	4	3	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:V44	R:R:Y107	3.79	0	No	No	6	9	2	1
R:R:R55	R:R:Y272	15.43	3	Yes	Yes	9	5	2	2
R:R:H276	R:R:R55	13.54	3	Yes	Yes	9	9	1	2
R:R:S194	R:R:T101	4.8	0	No	No	8	8	1	2
R:R:L103	R:R:Y107	10.55	0	No	No	9	9	2	1
R:R:L103	R:R:L280	4.15	0	No	No	9	9	2	2
R:R:G104	W:W:?1	7.44	0	No	Yes	8	0	1	0
R:R:Y107	W:W:?1	13.84	0	No	Yes	9	0	1	0
R:R:I111	R:R:L201	7.14	0	No	No	9	9	2	1
R:R:F191	R:R:F237	10.72	0	No	No	7	6	2	1
R:R:S194	W:W:?1	7.47	0	No	Yes	8	0	1	0
R:R:F237	R:R:L195	10.96	0	No	No	6	7	1	2
R:R:F198	R:R:I202	8.79	3	Yes	No	7	8	1	2
R:R:F198	R:R:V233	9.18	3	Yes	No	7	7	1	1
R:R:F198	R:R:I234	5.02	3	Yes	No	7	5	1	2
R:R:F198	W:W:?1	20.44	3	Yes	Yes	7	0	1	0
R:R:L201	R:R:M205	5.65	0	No	No	9	9	1	2
R:R:L201	W:W:?1	5.16	0	No	Yes	9	0	1	0
R:R:V233	W:W:?1	12.96	3	No	Yes	7	0	1	0
R:R:F236	R:R:Y272	4.13	3	Yes	Yes	9	5	2	2
R:R:F236	R:R:H276	10.18	3	Yes	Yes	9	9	2	1
R:R:F237	W:W:?1	6.06	0	No	Yes	6	0	1	0
R:R:H276	R:R:Y272	11.98	3	Yes	Yes	9	5	1	2
R:R:H276	R:R:L280	5.14	3	Yes	No	9	9	1	2
R:R:H276	W:W:?1	13.59	3	Yes	Yes	9	0	1	0
R:R:S232	R:R:V233	3.23	0	No	No	7	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8XQN_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.79
Number of Linked Nodes	266
Number of Links	292
Number of Hubs	37
Number of Links mediated by Hubs	155
Number of Communities	8
Number of Nodes involved in Communities	51
Number of Links involved in Communities	64

Path Summary
Number Of Nodes in MetaPath	47
Number Of Links MetaPath	46
Number of Shortest Paths	55215
Length Of Smallest Path	3
Average Path Length	13.4912
Length of Longest Path	30
Minimum Path Strength	1.44
Average Path Strength	8.31049
Maximum Path Strength	28.915
Minimum Path Correlation	0.7
Average Path Correlation	0.930692
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	45.8641
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.1868
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • cation binding • ion binding • metal ion binding • small molecule binding • hydrolase activity, acting on glycosyl bonds • alpha-sialidase activity • hydrolase activity, hydrolyzing O-glycosyl compounds • exo-alpha-sialidase activity • taste receptor activity • molecular transducer activity • transmembrane signaling receptor activity • signaling receptor activity • bitter taste receptor activity • G protein-coupled receptor activity • membrane lipid metabolic process • sphingolipid catabolic process • ceramide metabolic process • ganglioside catabolic process • carbohydrate derivative catabolic process • glycosphingolipid catabolic process • catabolic process • lipid catabolic process • glycolipid metabolic process • glycosphingolipid metabolic process • liposaccharide metabolic process • carbohydrate derivative metabolic process • primary metabolic process • sphingolipid metabolic process • membrane lipid catabolic process • glycolipid catabolic process • ceramide catabolic process • metabolic process • amide metabolic process • ganglioside metabolic process • lipid metabolic process • carbohydrate metabolic process • oligosaccharide catabolic process • oligosaccharide metabolic process • carbohydrate catabolic process • detection of chemical stimulus involved in sensory perception of bitter taste • detection of chemical stimulus involved in sensory perception of taste • detection of stimulus • detection of chemical stimulus • sensory perception of bitter taste • detection of stimulus involved in sensory perception • detection of chemical stimulus involved in sensory perception
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	GOQ
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	GOQ
Name	8-methoxy-6-nitro-naphtho[1,2-e][1,3]benzodioxole-5-carboxylic acid
Synonyms
Identifier
Formula	C17 H11 N O7
Molecular Weight	341.272
SMILES
PubChem	2236
Formal Charge	0
Total Atoms	36
Total Chiral Atoms	0
Total Bonds	39
Total Aromatic Bonds	16


Code	CLR
PDB Residues	L:L:?2
Environment Details	Open EMBL-EBI Page
Code	CLR
Name	Cholesterol
Synonyms	Cholesterol Cholesterin Cholest-5-en-3beta-ol (3β,14β,17α)-cholest-5-en-3-ol
Identifier
Formula	C27 H46 O
Molecular Weight	386.654
SMILES
PubChem	5997
Formal Charge	0
Total Atoms	74
Total Chiral Atoms	8
Total Bonds	77
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9NYV8
Sequence	>8XQN_nogp_Chain_R G G V I K S I F T F V L I V E F I I G N L G N S F I A L V N C I D W V K G R K I S S V D R I L T A L A I S R I S L V W L I F G S W C V S V F F P A L F A T E K M F R M L T N I W T V I N H F S V W L A T G L G T F Y F L K I A N F S N S I F L Y L K W R V K K V V L V L L L V T S V F L F L N I A L I N I H I N A S I N G Y R F T R F S S L I V L T S T V F I F I P F T L S L A M F L L L I F S M W K H R K K M Q H T V K D A S T K A H R G V K S V I T F F L L Y A I F S L S F F I S V W T S E R L E E N L I I L S Q V M G M A Y P S C H S C V L I L G N K K L R Q A S L S V L L W L R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8RQL	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Flufenamic acid	Flufenamic acid	chim(NtGi1-Gt3)/β1/γ2	3.03	2024-11-27	doi.org/10.1038/s41467-024-54157-6
	8RQL (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Flufenamic acid	Flufenamic acid		3.03	2024-11-27	doi.org/10.1038/s41467-024-54157-6
	8XQR	T2	Sensory	Taste2	TAS2R14	Homo sapiens	-	Flufenamic acid	Gt3/β1/γ1	3.2	2024-07-10	doi.org/10.1038/s41586-024-07569-9
	8XQR (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	-	Flufenamic acid		3.2	2024-07-10	doi.org/10.1038/s41586-024-07569-9
	8XQS	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Flufenamic acid	Gi1/β1/γ1	3.3	2024-07-10	doi.org/10.1038/s41586-024-07569-9
	8XQS (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Flufenamic acid		3.3	2024-07-10	doi.org/10.1038/s41586-024-07569-9
	8XQL	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A	Gt3/β1/γ1	2.99	2024-07-10	doi.org/10.1038/s41586-024-07569-9
	8XQL (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A		2.99	2024-07-10	doi.org/10.1038/s41586-024-07569-9
	8XQN	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A	Gi1/β1/γ1	3.05	2024-07-10	doi.org/10.1038/s41586-024-07569-9
	8XQN (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A		3.05	2024-07-10	doi.org/10.1038/s41586-024-07569-9
	8XQO	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A	Gi1/β1/γ1	2.77	2024-07-10	doi.org/10.1038/s41586-024-07569-9
	8XQO (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A		2.77	2024-07-10	doi.org/10.1038/s41586-024-07569-9
	8XQP	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A	Gt3/β1/γ1	3.29	2024-07-10	doi.org/10.1038/s41586-024-07569-9
	8XQP (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A		3.29	2024-07-10	doi.org/10.1038/s41586-024-07569-9
	8XQT	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	-	Gi1/β1/γ1	2.94	2024-07-10	doi.org/10.1038/s41586-024-07569-9
	8XQT (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	-		2.94	2024-07-10	doi.org/10.1038/s41586-024-07569-9

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