Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:F17 15.57525
2R:R:N24 6.2575409
3R:R:I27 3.695409
4R:R:L48 5.6025468
5R:R:L51 6.8275409
6R:R:R55 9.786549
7R:R:F63 11.412524
8R:R:W66 8.616524
9R:R:R83 6.1725403
10R:R:W89 15.46414
11R:R:N93 8.71418
12R:R:H94 7.862515
13R:R:W98 14.058519
14R:R:F106 7.8025407
15R:R:F108 6.5475438
16R:R:F114 4.335438
17R:R:H151 7.5775402
18R:R:F172 5.91453
19R:R:F175 8.2452
20R:R:T184 7.5075415
21R:R:P190 9.98419
22R:R:M197 5.76408
23R:R:F236 6.94549
24R:R:F243 4.0725407
25R:R:F247 8.806513
26R:R:F248 9.0725414
27R:R:W252 10.036513
28R:R:L264 7.4425414
29R:R:Q266 12.59423
30R:R:Y272 11.1525445
31L:L:?1 10.32821110
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:F247 R:R:M268 13.74348.71YesNo035
2R:R:M268 R:R:V267 85.57884.56NoNo054
3R:R:L13 R:R:V267 86.07535.96NoNo044
4R:R:L13 R:R:Q266 86.565821.3NoYes043
5R:R:M270 R:R:V59 10.99657.61NoNo047
6R:R:F17 R:R:V59 12.06373.93YesNo057
7R:R:F17 R:R:F63 96.465335.37YesYes254
8R:R:F17 R:R:N21 50.353821.75YesNo256
9R:R:F17 R:R:W60 50.353813.03YesNo253
10R:R:I56 R:R:N21 50.26464.25NoNo266
11R:R:I56 R:R:W60 50.26464.7NoNo263
12R:R:A52 R:R:N24 74.60913.13NoYes089
13R:R:I56 R:R:N24 1009.91NoYes069
14R:R:N24 R:R:R55 40.02326.03YesYes099
15R:R:K286 R:R:N284 19.51964.2NoNo089
16R:R:L287 R:R:N284 18.17296.87NoNo699
17R:R:I27 R:R:L287 67.46544.28YesNo099
18R:R:A52 R:R:I27 73.83913.25NoYes089
19R:R:F106 R:R:V44 37.48443.93YesNo076
20R:R:L48 R:R:V44 49.02194.47YesNo086
21R:R:L287 R:R:L48 48.43934.15NoYes698
22R:R:V44 R:R:Y107 12.73866.31NoNo069
23L:L:?1 R:R:M268 76.080615.51YesNo005
24L:L:?1 R:R:W89 38.260329.53YesYes104
25R:R:N93 R:R:W89 31.642819.21YesYes184
26R:R:N93 R:R:V97 30.20394.43YesNo185
27R:R:P190 R:R:V97 29.37453.53YesNo195
28R:R:P190 R:R:W98 25.456324.32YesYes199
29R:R:R55 R:R:Y272 15.854110.29YesYes495
30R:R:H276 R:R:R55 15.857111.28NoYes499
31L:L:?1 R:R:L85 13.205312.42YesNo002
32R:R:L61 R:R:L85 11.29384.15NoNo042
33R:R:I88 R:R:L61 10.30687.14NoNo034
34R:R:F175 R:R:I179 13.96938.79YesNo023
35L:L:?1 R:R:I179 14.90285.69YesNo003
36R:R:H94 R:R:W98 15.470614.81YesYes159
37R:R:H94 R:R:N144 10.00655.1YesNo055
38R:R:F119 R:R:N116 25.016315.71NoNo098
39R:R:I118 R:R:N116 26.10145.66NoNo048
40R:R:I118 R:R:L122 27.18064.28NoNo048
41R:R:L122 R:R:V129 28.14677.45NoNo086
42R:R:L109 R:R:V129 29.22594.47NoNo076
43R:R:L109 R:R:V126 30.3028.94NoNo077
44R:R:F106 R:R:V126 31.36047.87YesNo077
45R:R:F114 R:R:F119 14.66794.29YesNo389
46R:R:F236 R:R:Y272 14.79876.19YesYes495
47R:R:F236 R:R:V279 20.5726.55YesNo097
48R:R:S232 R:R:V279 18.30976.46NoNo077
49R:R:L282 R:R:S232 16.04149.01NoNo067
50R:R:F236 R:R:H276 14.760112.44YesNo499
51R:R:L282 R:R:R228 13.76726.07NoNo065
52R:R:R228 R:R:R288 11.4874.26NoNo058
53R:R:F63 R:R:Q266 83.71194.68YesYes243
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L58 R:R:W89 5.69 1 No Yes 4 4 2 1
R:R:L58 R:R:N93 4.12 1 No Yes 4 8 2 2
R:R:L61 R:R:L85 4.15 0 No No 4 2 2 1
R:R:L85 R:R:S65 9.01 0 No No 2 4 1 2
L:L:?1 R:R:L85 12.42 1 Yes No 0 2 0 1
L:L:?1 R:R:T86 16.17 1 Yes No 0 3 0 1
R:R:N93 R:R:W89 19.21 1 Yes Yes 8 4 2 1
R:R:S183 R:R:W89 7.41 0 No Yes 7 4 2 1
L:L:?1 R:R:W89 29.53 1 Yes Yes 0 4 0 1
R:R:F175 R:R:I179 8.79 5 Yes No 2 3 2 1
L:L:?1 R:R:I179 5.69 1 Yes No 0 3 0 1
R:R:V180 R:R:V251 8.02 1 No No 3 3 1 2
R:R:V180 R:R:W252 6.13 1 No Yes 3 3 1 2
L:L:?1 R:R:V180 5.94 1 Yes No 0 3 0 1
R:R:F188 R:R:T184 6.49 1 No Yes 3 5 1 1
R:R:F248 R:R:T184 10.38 1 Yes Yes 4 5 1 1
R:R:T184 R:R:W252 7.28 1 Yes Yes 5 3 1 2
L:L:?1 R:R:T184 5.88 1 Yes Yes 0 5 0 1
L:L:?1 R:R:F188 3.64 1 Yes No 0 3 0 1
R:R:F248 R:R:S244 3.96 1 Yes No 4 5 1 2
R:R:F247 R:R:V251 10.49 1 Yes No 3 3 2 2
R:R:F247 R:R:M268 8.71 1 Yes No 3 5 2 1
R:R:F248 R:R:W252 11.02 1 Yes Yes 4 3 1 2
L:L:?1 R:R:F248 10.93 1 Yes Yes 0 4 0 1
R:R:V251 R:R:W252 9.81 1 No Yes 3 3 2 2
L:L:?1 R:R:S265 4.49 1 Yes No 0 4 0 1
R:R:M268 R:R:V267 4.56 0 No No 5 4 1 2
L:L:?1 R:R:M268 15.51 1 Yes No 0 5 0 1
L:L:?1 R:R:G269 3.41 1 Yes No 0 4 0 1
R:R:I262 R:R:S265 3.1 0 No No 1 4 2 1
R:R:F188 R:R:T192 1.3 1 No No 3 4 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8XQT_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.13
Number of Linked Nodes 254
Number of Links 270
Number of Hubs 31
Number of Links mediated by Hubs 119
Number of Communities 6
Number of Nodes involved in Communities 45
Number of Links involved in Communities 60
Path Summary
Number Of Nodes in MetaPath 54
Number Of Links MetaPath 53
Number of Shortest Paths 50229
Length Of Smallest Path 3
Average Path Length 17.8214
Length of Longest Path 43
Minimum Path Strength 1.295
Average Path Strength 9.17419
Maximum Path Strength 28.56
Minimum Path Correlation 0.7
Average Path Correlation 0.929111
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.22581
Average % Of Corr. Nodes 38.4277
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 38.3696
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development
Gene OntologyBiological Process• multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • cation binding   • ion binding   • binding   • metal ion binding   • small molecule binding   • hydrolase activity, acting on glycosyl bonds   • alpha-sialidase activity   • hydrolase activity, hydrolyzing O-glycosyl compounds   • hydrolase activity   • exo-alpha-sialidase activity   • catalytic activity   • taste receptor activity   • molecular transducer activity   • transmembrane signaling receptor activity   • signaling receptor activity   • bitter taste receptor activity   • G protein-coupled receptor activity   • membrane lipid metabolic process   • sphingolipid catabolic process   • ceramide metabolic process   • ganglioside catabolic process   • carbohydrate derivative catabolic process   • glycosphingolipid catabolic process   • catabolic process   • lipid catabolic process   • glycolipid metabolic process   • glycosphingolipid metabolic process   • liposaccharide metabolic process   • carbohydrate derivative metabolic process   • primary metabolic process   • sphingolipid metabolic process   • membrane lipid catabolic process   • glycolipid catabolic process   • ceramide catabolic process   • metabolic process   • cellular process   • amide metabolic process   • ganglioside metabolic process   • lipid metabolic process   • carbohydrate metabolic process   • oligosaccharide catabolic process   • oligosaccharide metabolic process   • carbohydrate catabolic process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • G protein-coupled receptor signaling pathway   • signal transduction   • cell communication   • multicellular organismal process   • system process   • nervous system process   • detection of chemical stimulus involved in sensory perception of bitter taste   • detection of chemical stimulus involved in sensory perception of taste   • detection of stimulus   • sensory perception of chemical stimulus   • sensory perception   • sensory perception of taste   • response to chemical   • detection of chemical stimulus   • sensory perception of bitter taste   • detection of stimulus involved in sensory perception   • detection of chemical stimulus involved in sensory perception   • protein binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • D2 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • enzyme regulator activity   • adenylate cyclase inhibitor activity   • cyclase regulator activity   • molecular function inhibitor activity   • cyclase inhibitor activity   • molecular function regulator activity   • enzyme inhibitor activity   • adenylate cyclase regulator activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • magnesium ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity, acting on acid anhydrides   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • response to peptide hormone   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • negative regulation of protein transport   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • negative regulation of biological process   • negative regulation of transport   • localization   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • intracellular protein localization   • regulation of biological quality   • regulation of peptide hormone secretion   • negative regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • negative regulation of establishment of protein localization   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • negative regulation of protein secretion   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • negative regulation of signaling   • hormone secretion   • negative regulation of cell communication   • protein localization to extracellular region   • negative regulation of peptide secretion   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • negative regulation of cellular process   • negative regulation of protein localization   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • negative regulation of insulin secretion   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of protein localization to cell cortex   • positive regulation of protein localization   • protein localization to cell cortex   • cellular response to forskolin   • response to forskolin   • midbody   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell cortex   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • nucleoplasm   • Golgi apparatus   • endomembrane system   • ciliary basal body
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeCLR
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeCLR
NameCholesterol
Synonyms
  • Cholesterol
  • Cholesterin
  • Cholest-5-en-3beta-ol
  • (3β,14β,17α)-cholest-5-en-3-ol
Identifier
FormulaC27 H46 O
Molecular Weight386.654
SMILES
PubChem5997
Formal Charge0
Total Atoms74
Total Chiral Atoms8
Total Bonds77
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ9NYV8
Sequence
>8XQT_nogp_Chain_R
GGVIKSIFT FVLIVEFII GNLGNSFIA LVNCIDWVK GRKISSVDR 
ILTALAISR ISLVWLIFG SWCVSVFFP ALFATEKMF RMLTNIWTV 
INHFSVWLA TGLGTFYFL KIANFSNSI FLYLKWRVK KVVLVLLLV 
TSVFLFLNI ALINIHINA SINGFTRFS SLIVLTSTV FIFIPFTLS 
LAMFLLLIF SMWKHRKKM QHTVRGVKS VITFFLLYA IFSLSFFIS 
VWTSERLEE NLIILSQVM GMAYPSCHS CVLILGNKK LRQASLSVL 
LWLR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8RQLT2SensoryTaste2TAS2R14Homo sapiensFlufenamic acidFlufenamic acidchim(NtGi1-Gt3)/β1/γ23.032024-11-27doi.org/10.1038/s41467-024-54157-6
8RQL (No Gprot) T2SensoryTaste2TAS2R14Homo sapiensFlufenamic acidFlufenamic acid3.032024-11-27doi.org/10.1038/s41467-024-54157-6
8XQRT2SensoryTaste2TAS2R14Homo sapiens-Flufenamic acidGt3/β1/γ13.22024-07-10doi.org/10.1038/s41586-024-07569-9
8XQR (No Gprot) T2SensoryTaste2TAS2R14Homo sapiens-Flufenamic acid3.22024-07-10doi.org/10.1038/s41586-024-07569-9
8XQST2SensoryTaste2TAS2R14Homo sapiensCholesterolFlufenamic acidGi1/β1/γ13.32024-07-10doi.org/10.1038/s41586-024-07569-9
8XQS (No Gprot) T2SensoryTaste2TAS2R14Homo sapiensCholesterolFlufenamic acid3.32024-07-10doi.org/10.1038/s41586-024-07569-9
8XQLT2SensoryTaste2TAS2R14Homo sapiensCholesterolAristolochic acid AGt3/β1/γ12.992024-07-10doi.org/10.1038/s41586-024-07569-9
8XQL (No Gprot) T2SensoryTaste2TAS2R14Homo sapiensCholesterolAristolochic acid A2.992024-07-10doi.org/10.1038/s41586-024-07569-9
8XQNT2SensoryTaste2TAS2R14Homo sapiensCholesterolAristolochic acid AGi1/β1/γ13.052024-07-10doi.org/10.1038/s41586-024-07569-9
8XQN (No Gprot) T2SensoryTaste2TAS2R14Homo sapiensCholesterolAristolochic acid A3.052024-07-10doi.org/10.1038/s41586-024-07569-9
8XQOT2SensoryTaste2TAS2R14Homo sapiensCholesterolAristolochic acid AGi1/β1/γ12.772024-07-10doi.org/10.1038/s41586-024-07569-9
8XQO (No Gprot) T2SensoryTaste2TAS2R14Homo sapiensCholesterolAristolochic acid A2.772024-07-10doi.org/10.1038/s41586-024-07569-9
8XQPT2SensoryTaste2TAS2R14Homo sapiensCholesterolAristolochic acid AGt3/β1/γ13.292024-07-10doi.org/10.1038/s41586-024-07569-9
8XQP (No Gprot) T2SensoryTaste2TAS2R14Homo sapiensCholesterolAristolochic acid A3.292024-07-10doi.org/10.1038/s41586-024-07569-9
8XQTT2SensoryTaste2TAS2R14Homo sapiensCholesterol-Gi1/β1/γ12.942024-07-10doi.org/10.1038/s41586-024-07569-9
8XQT (No Gprot) T2SensoryTaste2TAS2R14Homo sapiensCholesterol-2.942024-07-10doi.org/10.1038/s41586-024-07569-9




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8XQT_nogp.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.