psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E259	R:R:K6	10.8	No	No	0	4	4
2	R:R:I263	R:R:K6	11.63	No	No	0	4	4
3	R:R:F11	R:R:S7	3.96	No	No	0	5	3
4	R:R:T10	R:R:W66	8.49	No	Yes	0	5	4
5	R:R:E16	R:R:V12	4.28	No	No	0	8	6
6	R:R:L13	R:R:Q266	21.3	No	Yes	0	4	3
7	R:R:L13	R:R:V267	5.96	No	No	0	4	4
8	R:R:F63	R:R:I14	5.02	Yes	No	0	4	4
9	R:R:E16	R:R:F243	5.83	No	Yes	0	8	7
10	R:R:E16	R:R:M270	13.53	No	No	0	8	4
11	R:R:F17	R:R:N21	21.75	Yes	No	3	5	6
12	R:R:F17	R:R:V59	3.93	Yes	No	0	5	7
13	R:R:F17	R:R:W60	13.03	Yes	No	3	5	3
14	R:R:F17	R:R:F63	35.37	Yes	Yes	3	5	4
15	R:R:I56	R:R:N21	4.25	No	No	3	6	6
16	R:R:N21	R:R:W60	5.65	No	No	3	6	3
17	R:R:N24	R:R:R55	6.03	No	Yes	0	9	9
18	R:R:I56	R:R:N24	9.91	No	No	0	6	9
19	R:R:N24	R:R:S277	5.96	No	No	0	9	9
20	R:R:F26	R:R:S291	5.28	No	No	0	8	5
21	R:R:F26	R:R:V294	5.24	No	No	0	8	5
22	R:R:I27	R:R:I281	4.42	Yes	No	0	9	9
23	R:R:I27	R:R:L287	4.28	Yes	No	0	9	9
24	R:R:I33	R:R:L29	4.28	No	No	0	4	5
25	R:R:D45	R:R:N31	6.73	No	No	0	8	8
26	R:R:N31	R:R:T49	16.08	No	No	0	8	6
27	R:R:D34	R:R:R39	21.44	No	No	0	6	6
28	R:R:D34	R:R:K286	8.3	No	No	0	6	8
29	R:R:K37	R:R:R39	4.95	No	No	0	6	6
30	R:R:D45	R:R:I41	11.2	No	No	0	8	6
31	R:R:D45	R:R:S42	5.89	No	No	0	8	8
32	R:R:F106	R:R:S43	13.21	Yes	No	0	7	6
33	R:R:L48	R:R:V44	4.47	Yes	No	0	8	6
34	R:R:F106	R:R:V44	3.93	Yes	No	0	7	6
35	R:R:V44	R:R:Y107	6.31	No	Yes	0	6	9
36	R:R:K127	R:R:R46	11.14	No	No	0	7	5
37	R:R:I47	R:R:L103	8.56	No	No	0	9	9
38	R:R:L280	R:R:L48	6.92	No	Yes	0	9	8
39	R:R:L48	R:R:N284	6.87	Yes	No	5	8	9
40	R:R:L287	R:R:L48	4.15	No	Yes	5	9	8
41	R:R:L51	R:R:R55	17.01	Yes	Yes	0	9	9
42	R:R:L51	R:R:L99	4.15	Yes	No	0	9	5
43	R:R:R55	R:R:Y272	10.29	Yes	Yes	2	9	5
44	R:R:P273	R:R:R55	4.32	No	Yes	2	8	9
45	R:R:H276	R:R:R55	11.28	Yes	Yes	2	9	9
46	R:R:I56	R:R:W60	4.7	No	No	3	6	3
47	R:R:I92	R:R:S57	4.64	No	No	0	4	3
48	R:R:L58	R:R:W89	5.69	No	Yes	1	4	4
49	R:R:I92	R:R:L58	7.14	No	No	0	4	4
50	R:R:L58	R:R:N93	4.12	No	Yes	1	4	8
51	R:R:M270	R:R:V59	7.61	No	No	0	4	7
52	R:R:L61	R:R:L85	4.15	No	No	0	4	2
53	R:R:I88	R:R:L61	7.14	No	No	0	3	4
54	R:R:I62	R:R:Q266	6.86	No	Yes	0	4	3
55	R:R:F63	R:R:W66	5.01	Yes	Yes	3	4	4
56	R:R:C67	R:R:F63	6.98	No	Yes	0	4	4
57	R:R:F63	R:R:Q266	4.68	Yes	Yes	3	4	3
58	R:R:L85	R:R:S65	9.01	No	No	0	2	4
59	R:R:V70	R:R:W66	7.36	No	Yes	0	4	4
60	R:R:I263	R:R:W66	4.7	No	Yes	0	4	4
61	R:R:Q266	R:R:W66	17.52	Yes	Yes	3	3	4
62	R:R:F76	R:R:S69	14.53	No	No	0	3	4
63	R:R:A74	R:R:F72	8.32	No	No	0	2	4
64	R:R:F72	R:R:L75	10.96	No	No	0	4	2
65	R:R:F76	R:R:M81	7.46	No	No	0	3	3
66	R:R:F76	R:R:I262	7.54	No	No	0	3	1
67	R:R:M81	R:R:T78	4.52	No	No	0	3	4
68	R:R:E79	R:R:F82	13.99	No	No	0	2	2
69	R:R:E79	R:R:I156	5.47	No	No	0	2	3
70	R:R:E79	R:R:F172	5.83	No	No	0	2	3
71	R:R:K80	R:R:R83	9.9	No	Yes	0	3	3
72	R:R:F175	R:R:F82	9.65	Yes	No	0	2	2
73	R:R:M84	R:R:R83	4.96	No	Yes	0	3	3
74	R:R:N87	R:R:R83	4.82	No	Yes	0	4	3
75	R:R:I152	R:R:R83	5.01	No	Yes	0	3	3
76	R:R:I88	R:R:M84	5.83	No	No	0	3	3
77	L:L:?1	R:R:L85	12.42	Yes	No	0	0	2
78	L:L:?1	R:R:T86	16.17	Yes	No	0	0	3
79	R:R:I145	R:R:N87	5.66	No	No	0	6	4
80	R:R:N93	R:R:W89	19.21	Yes	Yes	1	8	4
81	R:R:S183	R:R:W89	7.41	No	Yes	0	7	4
82	L:L:?1	R:R:W89	29.53	Yes	Yes	1	0	4
83	R:R:I145	R:R:T90	4.56	No	No	0	6	5
84	R:R:I148	R:R:T90	4.56	No	No	0	4	5
85	R:R:F95	R:R:V91	3.93	No	No	0	6	6
86	R:R:L141	R:R:V91	4.47	No	No	0	8	6
87	R:R:N93	R:R:V97	4.43	Yes	No	1	8	5
88	R:R:I187	R:R:N93	7.08	No	Yes	1	5	8
89	R:R:H94	R:R:W98	14.81	Yes	Yes	4	5	9
90	R:R:H94	R:R:T137	6.85	Yes	No	4	5	8
91	R:R:H94	R:R:L141	10.29	Yes	No	0	5	8
92	R:R:H94	R:R:N144	5.1	Yes	No	0	5	5
93	R:R:I187	R:R:V97	6.14	No	No	1	5	5
94	R:R:T101	R:R:W98	4.85	No	Yes	4	8	9
95	R:R:L133	R:R:W98	5.69	No	Yes	0	7	9
96	R:R:T137	R:R:W98	20.62	No	Yes	4	8	9
97	R:R:P190	R:R:W98	24.32	No	Yes	4	9	9
98	R:R:P190	R:R:T101	6.99	No	No	4	9	8
99	R:R:L103	R:R:Y107	9.38	No	Yes	2	9	9
100	R:R:L103	W:W:?2	8.28	No	Yes	2	9	0
101	R:R:M197	R:R:T105	6.02	Yes	No	0	8	7
102	R:R:F106	R:R:K110	6.2	Yes	No	0	7	9
103	R:R:F106	R:R:V126	7.87	Yes	No	0	7	7
104	R:R:Y107	W:W:?2	8.18	Yes	Yes	2	9	0
105	R:R:F108	R:R:M197	12.44	Yes	Yes	0	8	8
106	R:R:F108	R:R:L200	7.31	Yes	No	0	8	7
107	R:R:L109	R:R:V126	8.94	No	No	0	7	7
108	R:R:L109	R:R:V129	4.47	No	No	0	7	6
109	R:R:I111	R:R:L201	5.71	No	No	0	9	9
110	R:R:I111	R:R:M205	4.37	No	No	0	9	9
111	R:R:F114	R:R:F119	4.29	Yes	No	6	8	9
112	R:R:F114	R:R:S204	6.61	Yes	No	0	8	9
113	R:R:I118	R:R:N116	5.66	No	No	0	4	8
114	R:R:F119	R:R:N116	15.71	No	No	0	9	8
115	R:R:I118	R:R:L122	4.28	No	No	0	4	8
116	R:R:L120	R:R:W124	6.83	No	No	0	7	4
117	R:R:R125	R:R:Y121	17.49	No	No	0	8	5
118	R:R:L122	R:R:V129	7.45	No	No	0	8	6
119	R:R:K123	R:R:W124	13.92	No	No	0	9	4
120	R:R:K128	R:R:R125	9.9	No	No	0	6	8
121	R:R:F186	R:R:N144	24.17	No	No	0	4	5
122	R:R:H151	R:R:L147	5.14	Yes	No	0	2	4
123	R:R:F186	R:R:L147	6.09	No	No	0	4	4
124	R:R:I148	R:R:T182	4.56	No	No	0	4	6
125	R:R:N149	R:R:N153	12.26	No	No	0	4	3
126	R:R:H151	R:R:L178	11.57	Yes	No	0	2	3
127	R:R:H151	R:R:T182	10.95	Yes	No	0	2	6
128	R:R:R174	R:R:S155	3.95	No	No	0	2	3
129	R:R:F175	R:R:S155	7.93	Yes	No	0	2	3
130	R:R:F172	R:R:F175	6.43	No	Yes	0	3	2
131	R:R:E258	R:R:F172	8.16	No	No	0	4	3
132	R:R:E255	R:R:T173	7.06	No	No	0	2	3
133	R:R:F175	R:R:I179	8.79	Yes	No	0	2	3
134	R:R:L261	R:R:S176	9.01	No	No	0	1	4
135	L:L:?1	R:R:I179	5.69	Yes	No	0	0	3
136	R:R:V180	R:R:V251	8.02	No	No	1	3	3
137	R:R:V180	R:R:W252	6.13	No	Yes	1	3	3
138	L:L:?1	R:R:V180	5.94	Yes	No	1	0	3
139	R:R:L181	R:R:W252	15.94	No	Yes	0	2	3
140	R:R:F188	R:R:T184	6.49	No	Yes	0	3	5
141	R:R:F248	R:R:T184	10.38	Yes	Yes	1	4	5
142	R:R:T184	R:R:W252	7.28	Yes	Yes	1	5	3
143	L:L:?1	R:R:T184	5.88	Yes	Yes	1	0	5
144	R:R:I189	R:R:P190	5.08	No	No	0	6	9
145	R:R:F191	W:W:?2	8.5	No	Yes	0	7	0
146	R:R:S194	W:W:?2	8.98	No	Yes	0	8	0
147	R:R:L195	R:R:L199	4.15	No	No	0	7	4
148	R:R:L195	W:W:?2	12.42	No	Yes	0	7	0
149	R:R:F198	R:R:I202	13.82	No	No	0	7	8
150	R:R:F198	W:W:?2	27.93	No	Yes	0	7	0
151	R:R:F203	R:R:W206	4.01	No	No	0	5	4
152	R:R:F203	R:R:K207	12.41	No	No	0	5	7
153	R:R:K210	R:R:W206	12.76	No	No	0	6	4
154	R:R:H208	R:R:M212	3.94	No	No	0	9	9
155	R:R:H214	R:R:T215	5.48	No	No	0	5	6
156	R:R:L282	R:R:R228	6.07	No	No	0	6	5
157	R:R:R228	R:R:R288	4.26	No	No	0	5	8
158	R:R:S232	R:R:V279	6.46	No	No	0	7	7
159	R:R:L282	R:R:S232	9.01	No	No	0	6	7
160	R:R:F237	R:R:V233	3.93	No	No	2	6	7
161	R:R:V233	W:W:?2	13.37	No	Yes	2	7	0
162	R:R:F236	R:R:F237	6.43	Yes	No	2	9	6
163	R:R:F236	R:R:Y272	6.19	Yes	Yes	2	9	5
164	R:R:F236	R:R:H276	12.44	Yes	Yes	2	9	9
165	R:R:F236	R:R:V279	6.55	Yes	No	0	9	7
166	R:R:F237	W:W:?2	35.22	No	Yes	2	6	0
167	R:R:A271	R:R:F243	5.55	No	Yes	0	6	7
168	R:R:F248	R:R:S244	3.96	Yes	No	0	4	5
169	R:R:I249	R:R:L245	4.28	No	No	0	4	4
170	R:R:F247	R:R:V251	10.49	Yes	No	1	3	3
171	R:R:F247	R:R:R256	5.34	Yes	No	1	3	1
172	R:R:F247	R:R:L264	17.05	Yes	Yes	1	3	4
173	R:R:F247	R:R:M268	8.71	Yes	No	0	3	5
174	R:R:F248	R:R:W252	11.02	Yes	Yes	1	4	3
175	L:L:?1	R:R:F248	10.93	Yes	Yes	1	0	4
176	R:R:S250	R:R:S254	4.89	No	No	0	3	2
177	R:R:R256	R:R:S250	11.86	No	No	0	1	3
178	R:R:V251	R:R:W252	9.81	No	Yes	1	3	3
179	R:R:L264	R:R:R256	6.07	Yes	No	1	4	1
180	R:R:E259	R:R:L257	5.3	No	No	0	4	1
181	R:R:L257	R:R:N260	13.73	No	No	0	1	5
182	L:L:?1	R:R:S265	4.49	Yes	No	0	0	4
183	R:R:M268	R:R:V267	4.56	No	No	0	5	4
184	L:L:?1	R:R:M268	15.51	Yes	No	0	0	5
185	R:R:P273	R:R:Y272	4.17	No	Yes	2	8	5
186	R:R:H276	R:R:Y272	23.96	Yes	Yes	2	9	5
187	R:R:H276	W:W:?2	16.67	Yes	Yes	2	9	0
188	R:R:K286	R:R:N284	4.2	No	No	0	8	9
189	R:R:L287	R:R:N284	6.87	No	No	5	9	9
190	R:R:K285	R:R:R288	6.19	No	No	0	6	8
191	R:R:K285	R:R:Q289	6.78	No	No	0	6	7
192	R:R:L296	R:R:R299	4.86	No	No	0	3	7
193	R:R:L298	R:R:W297	5.69	No	No	0	5	3
194	R:R:C32	R:R:W35	3.92	No	No	0	4	5
195	R:R:F17	R:R:I18	3.77	Yes	No	0	5	6
196	R:R:V36	R:R:W35	3.68	No	No	0	5	5
197	R:R:V294	R:R:W297	3.68	No	No	0	5	3
198	R:R:F9	R:R:L264	3.65	No	Yes	0	4	4
199	R:R:F186	R:R:L143	3.65	No	No	0	4	3
200	R:R:F243	R:R:L239	3.65	Yes	No	0	7	7
201	R:R:G102	R:R:T105	3.64	No	No	0	5	7
202	R:R:I111	R:R:Y107	3.63	No	Yes	0	9	9
203	R:R:G2	R:R:I5	3.53	No	No	0	4	4
204	R:R:C275	R:R:S274	3.44	No	No	0	4	7
205	R:R:A112	R:R:S204	3.42	No	No	0	8	9
206	L:L:?1	R:R:G269	3.41	Yes	No	0	0	4
207	R:R:A290	R:R:V30	3.39	No	No	0	5	8
208	R:R:A52	R:R:I27	3.25	No	Yes	0	8	9
209	R:R:F108	R:R:F114	3.22	Yes	Yes	6	8	8
210	R:R:F108	R:R:F119	3.22	Yes	No	6	8	9
211	R:R:F114	R:R:F203	3.22	Yes	No	0	8	5
212	R:R:S250	R:R:T253	3.2	No	No	0	3	4
213	R:R:C275	R:R:L239	3.17	No	No	0	4	7
214	R:R:A100	R:R:L51	3.15	No	Yes	0	8	9
215	R:R:I8	R:R:S7	3.1	No	No	0	6	3
216	R:R:I262	R:R:S265	3.1	No	No	0	1	4
217	R:R:F236	R:R:Y240	3.09	Yes	No	0	9	8
218	R:R:L51	R:R:S96	3	Yes	No	0	9	7
219	R:R:L99	R:R:S54	3	No	No	0	5	9
220	R:R:L264	R:R:S246	3	Yes	No	0	4	5
221	R:R:L295	R:R:S291	3	No	No	0	7	5
222	R:R:N113	R:R:S204	2.98	No	No	0	8	9
223	R:R:L134	R:R:T137	2.95	No	No	0	8	8
224	R:R:I33	R:R:K37	2.91	No	No	0	4	6
225	R:R:F72	R:R:P73	2.89	No	No	0	4	4
226	R:R:K127	R:R:K128	2.87	No	No	0	7	6
227	R:R:I18	R:R:L22	2.85	No	No	0	6	4
228	R:R:I27	R:R:N31	2.83	Yes	No	0	9	8
229	R:R:I156	R:R:N157	2.83	No	No	0	3	1
230	R:R:L193	R:R:M197	2.83	No	Yes	0	5	8
231	R:R:H151	R:R:I150	2.65	Yes	No	0	2	3
232	R:R:F26	R:R:V30	2.62	No	No	0	8	8
233	R:R:F71	R:R:V70	2.62	No	No	0	4	4
234	R:R:F140	R:R:V136	2.62	No	No	0	3	6
235	R:R:F11	R:R:I14	2.51	No	No	0	5	4
236	R:R:F247	R:R:L261	2.44	Yes	No	0	3	1
237	R:R:F140	R:R:H94	2.26	No	Yes	0	3	5
238	R:R:G2	R:R:G3	2.11	No	No	0	4	4
239	R:R:G229	R:R:G283	2.11	No	No	0	9	7
240	R:R:G20	R:R:S274	1.86	No	No	0	9	7
241	R:R:G23	R:R:S277	1.86	No	No	0	7	9
242	R:R:G102	R:R:V130	1.84	No	No	0	5	7
243	R:R:G104	R:R:M197	1.75	No	Yes	0	8	8
244	R:R:G3	R:R:K6	1.74	No	No	0	4	4
245	R:R:C278	R:R:I19	1.64	No	No	0	5	5
246	R:R:S7	R:R:V4	1.62	No	No	0	3	4
247	R:R:A28	R:R:I53	1.62	No	No	0	7	6
248	R:R:A50	R:R:L99	1.58	No	No	0	6	5
249	R:R:I53	R:R:S57	1.55	No	No	0	6	3
250	R:R:I14	R:R:V15	1.54	No	No	0	4	5
251	R:R:I19	R:R:V15	1.54	No	No	0	5	5
252	R:R:I202	R:R:V230	1.54	No	No	0	8	7
253	R:R:K40	R:R:S42	1.53	No	No	0	6	8
254	R:R:K286	R:R:V30	1.52	No	No	0	8	8
255	R:R:K37	R:R:V36	1.52	No	No	0	6	5
256	R:R:M212	R:R:T215	1.51	No	No	0	9	6
257	R:R:L135	R:R:S138	1.5	No	No	0	6	6
258	R:R:G158	R:R:R174	1.5	No	No	0	2	2
259	R:R:K231	R:R:T235	1.5	No	No	0	7	7
260	R:R:G283	R:R:R288	1.5	No	No	0	7	8
261	R:R:L75	R:R:V68	1.49	No	No	0	2	3
262	R:R:L181	R:R:V185	1.49	No	No	0	2	6
263	R:R:K110	R:R:K123	1.44	No	No	0	9	9
264	R:R:I150	R:R:N149	1.42	No	No	0	3	4
265	R:R:K128	R:R:L131	1.41	No	No	0	6	6
266	R:R:L131	R:R:L134	1.38	No	No	0	6	8
267	R:R:H208	R:R:K211	1.31	No	No	0	9	5
268	R:R:F188	R:R:T192	1.3	No	No	0	3	4
269	R:R:F191	R:R:T192	1.3	No	No	0	7	4
270	R:R:H208	R:R:N113	1.28	No	No	0	9	8
271	R:R:F243	R:R:I242	1.26	Yes	No	0	7	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F17	15.57	5	3	5
2	R:R:I27	3.695	4	0	9
3	R:R:L48	5.6025	4	5	8
4	R:R:L51	6.8275	4	0	9
5	R:R:R55	9.786	5	2	9
6	R:R:F63	11.412	5	3	4
7	R:R:W66	8.616	5	3	4
8	R:R:R83	6.1725	4	0	3
9	R:R:W89	15.46	4	1	4
10	R:R:N93	8.71	4	1	8
11	R:R:H94	7.862	5	4	5
12	R:R:W98	14.058	5	4	9
13	R:R:F106	7.8025	4	0	7
14	R:R:Y107	6.875	4	2	9
15	R:R:F108	6.5475	4	6	8
16	R:R:F114	4.335	4	6	8
17	R:R:H151	7.5775	4	0	2
18	R:R:F175	8.2	4	0	2
19	R:R:T184	7.5075	4	1	5
20	R:R:M197	5.76	4	0	8
21	R:R:F236	6.94	5	2	9
22	R:R:F243	4.0725	4	0	7
23	R:R:F247	8.806	5	1	3
24	R:R:F248	9.0725	4	1	4
25	R:R:W252	10.036	5	1	3
26	R:R:L264	7.4425	4	1	4
27	R:R:Q266	12.59	4	3	3
28	R:R:Y272	11.1525	4	2	5
29	R:R:H276	16.0875	4	2	9
30	L:L:?1	10.997	10	1	0
31	W:W:?2	15.5056	9	2	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I263	R:R:K6	16.4499	11.63	No	No	0	4	4
2	R:R:I263	R:R:W66	18.6032	4.7	No	Yes	0	4	4
3	R:R:F63	R:R:W66	19.4683	5.01	Yes	Yes	3	4	4
4	R:R:F63	R:R:I14	18.9884	5.02	Yes	No	0	4	4
5	R:R:E16	R:R:M270	21.3627	13.53	No	No	0	8	4
6	R:R:M270	R:R:V59	23.6739	7.61	No	No	0	4	7
7	R:R:F17	R:R:V59	25.9725	3.93	Yes	No	0	5	7
8	R:R:F17	R:R:F63	50.6883	35.37	Yes	Yes	3	5	4
9	R:R:L13	R:R:Q266	28.7004	21.3	No	Yes	0	4	3
10	R:R:L13	R:R:V267	29.1677	5.96	No	No	0	4	4
11	R:R:E16	R:R:F243	16.7025	5.83	No	Yes	0	8	7
12	R:R:F17	R:R:N21	30.3359	21.75	Yes	No	3	5	6
13	R:R:F17	R:R:W60	30.3359	13.03	Yes	No	3	5	3
14	R:R:I56	R:R:N21	30.2033	4.25	No	No	3	6	6
15	R:R:I56	R:R:W60	30.2033	4.7	No	No	3	6	3
16	R:R:I56	R:R:N24	59.5668	9.91	No	No	0	6	9
17	R:R:N24	R:R:R55	61.3665	6.03	No	Yes	0	9	9
18	R:R:H276	R:R:R55	60.1478	11.28	Yes	Yes	2	9	9
19	R:R:H276	W:W:?2	69.02	16.67	Yes	Yes	2	9	0
20	R:R:Y107	W:W:?2	100	8.18	Yes	Yes	2	9	0
21	R:R:V44	R:R:Y107	96.71	6.31	No	Yes	0	6	9
22	R:R:L48	R:R:V44	51.0798	4.47	Yes	No	0	8	6
23	R:R:L48	R:R:N284	30.7085	6.87	Yes	No	5	8	9
24	R:R:K286	R:R:N284	30.1465	4.2	No	No	0	8	9
25	R:R:K286	R:R:V30	14.4291	1.52	No	No	0	8	8
26	R:R:F26	R:R:V30	10.9308	2.62	No	No	0	8	8
27	R:R:L287	R:R:L48	17.2581	4.15	No	Yes	5	9	8
28	R:R:I27	R:R:L287	16.7593	4.28	Yes	No	0	9	9
29	R:R:D34	R:R:K286	14.7765	8.3	No	No	0	6	8
30	R:R:D34	R:R:R39	13.122	21.44	No	No	0	6	6
31	R:R:K37	R:R:R39	11.2844	4.95	No	No	0	6	6
32	R:R:I27	R:R:N31	11.2844	2.83	Yes	No	0	9	8
33	R:R:F106	R:R:V44	57.1167	3.93	Yes	No	0	7	6
34	R:R:M268	R:R:V267	30.0644	4.56	No	No	0	5	4
35	L:L:?1	R:R:M268	38.8419	15.51	Yes	No	0	0	5
36	L:L:?1	R:R:L85	56.7568	12.42	Yes	No	0	0	2
37	R:R:L61	R:R:L85	54.6729	4.15	No	No	0	4	2
38	R:R:I88	R:R:L61	53.6689	7.14	No	No	0	3	4
39	R:R:I88	R:R:M84	52.4943	5.83	No	No	0	3	3
40	R:R:M84	R:R:R83	51.3008	4.96	No	Yes	0	3	3
41	R:R:N87	R:R:R83	47.6446	4.82	No	Yes	0	4	3
42	R:R:I145	R:R:N87	46.4006	5.66	No	No	0	6	4
43	R:R:I145	R:R:T90	45.144	4.56	No	No	0	6	5
44	R:R:I148	R:R:T90	43.8747	4.56	No	No	0	4	5
45	R:R:I148	R:R:T182	42.5928	4.56	No	No	0	4	6
46	R:R:H151	R:R:T182	41.2983	10.95	Yes	No	0	2	6
47	R:R:H151	R:R:L147	34.6363	5.14	Yes	No	0	2	4
48	R:R:F186	R:R:L147	33.266	6.09	No	No	0	4	4
49	R:R:F186	R:R:N144	30.4875	24.17	No	No	0	4	5
50	R:R:H94	R:R:N144	29.0793	5.1	Yes	No	0	5	5
51	R:R:H94	R:R:T137	12.5032	6.85	Yes	No	4	5	8
52	R:R:L134	R:R:T137	11.196	2.95	No	No	0	8	8
53	R:R:L51	R:R:R55	11.3981	17.01	Yes	Yes	0	9	9
54	L:L:?1	R:R:W89	15.6542	29.53	Yes	Yes	1	0	4
55	L:L:?1	R:R:I179	21.6848	5.69	Yes	No	0	0	3
56	R:R:F175	R:R:I179	20.2766	8.79	Yes	No	0	2	3
57	R:R:F106	R:R:V126	47.9603	7.87	Yes	No	0	7	7
58	R:R:L109	R:R:V126	46.3817	8.94	No	No	0	7	7
59	R:R:L109	R:R:V129	44.7651	4.47	No	No	0	7	6
60	R:R:L122	R:R:V129	43.1422	7.45	No	No	0	8	6
61	R:R:I118	R:R:L122	41.7088	4.28	No	No	0	4	8
62	R:R:I118	R:R:N116	40.0859	5.66	No	No	0	4	8
63	R:R:F119	R:R:N116	38.4504	15.71	No	No	0	9	8
64	R:R:F108	R:R:F119	14.2776	3.22	Yes	No	6	8	9
65	R:R:F108	R:R:M197	11.2844	12.44	Yes	Yes	0	8	8
66	R:R:F114	R:R:F119	22.4931	4.29	Yes	No	6	8	9
67	R:R:F114	R:R:S204	14.5681	6.61	Yes	No	0	8	9
68	R:R:F247	R:R:M268	16.3173	8.71	Yes	No	0	3	5
69	L:L:?1	R:R:T184	68.2496	5.88	Yes	Yes	1	0	5
70	R:R:T184	R:R:W252	13.4062	7.28	Yes	Yes	1	5	3
71	R:R:F188	R:R:T184	78.5678	6.49	No	Yes	0	3	5
72	R:R:F191	W:W:?2	78.9656	8.5	No	Yes	0	7	0
73	R:R:F188	R:R:T192	78.4226	1.3	No	No	0	3	4
74	R:R:F191	R:R:T192	78.5299	1.3	No	No	0	7	4
75	R:R:N113	R:R:S204	11.1013	2.98	No	No	0	8	9
76	R:R:F236	R:R:V279	31.8767	6.55	Yes	No	0	9	7
77	R:R:S232	R:R:V279	28.3847	6.46	No	No	0	7	7
78	R:R:L282	R:R:S232	24.88	9.01	No	No	0	6	7
79	R:R:F236	R:R:H276	19.8724	12.44	Yes	Yes	2	9	9
80	R:R:L282	R:R:R228	21.3627	6.07	No	No	0	6	5
81	R:R:R228	R:R:R288	17.8328	4.26	No	No	0	5	8
82	R:R:F236	R:R:F237	14.2081	6.43	Yes	No	2	9	6
83	R:R:F237	W:W:?2	14.5176	35.22	No	Yes	2	6	0
84	R:R:F63	R:R:Q266	22.752	4.68	Yes	Yes	3	4	3

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L58	R:R:W89	5.69	1	No	Yes	4	4	2	1
R:R:L58	R:R:N93	4.12	1	No	Yes	4	8	2	2
R:R:L61	R:R:L85	4.15	0	No	No	4	2	2	1
R:R:L85	R:R:S65	9.01	0	No	No	2	4	1	2
L:L:?1	R:R:L85	12.42	1	Yes	No	0	2	0	1
L:L:?1	R:R:T86	16.17	1	Yes	No	0	3	0	1
R:R:N93	R:R:W89	19.21	1	Yes	Yes	8	4	2	1
R:R:S183	R:R:W89	7.41	0	No	Yes	7	4	2	1
L:L:?1	R:R:W89	29.53	1	Yes	Yes	0	4	0	1
R:R:F175	R:R:I179	8.79	0	Yes	No	2	3	2	1
L:L:?1	R:R:I179	5.69	1	Yes	No	0	3	0	1
R:R:V180	R:R:V251	8.02	1	No	No	3	3	1	2
R:R:V180	R:R:W252	6.13	1	No	Yes	3	3	1	2
L:L:?1	R:R:V180	5.94	1	Yes	No	0	3	0	1
R:R:F188	R:R:T184	6.49	0	No	Yes	3	5	2	1
R:R:F248	R:R:T184	10.38	1	Yes	Yes	4	5	1	1
R:R:T184	R:R:W252	7.28	1	Yes	Yes	5	3	1	2
L:L:?1	R:R:T184	5.88	1	Yes	Yes	0	5	0	1
R:R:F248	R:R:S244	3.96	1	Yes	No	4	5	1	2
R:R:F247	R:R:V251	10.49	1	Yes	No	3	3	2	2
R:R:F247	R:R:M268	8.71	1	Yes	No	3	5	2	1
R:R:F248	R:R:W252	11.02	1	Yes	Yes	4	3	1	2
L:L:?1	R:R:F248	10.93	1	Yes	Yes	0	4	0	1
R:R:V251	R:R:W252	9.81	1	No	Yes	3	3	2	2
L:L:?1	R:R:S265	4.49	1	Yes	No	0	4	0	1
R:R:M268	R:R:V267	4.56	0	No	No	5	4	1	2
L:L:?1	R:R:M268	15.51	1	Yes	No	0	5	0	1
L:L:?1	R:R:G269	3.41	1	Yes	No	0	4	0	1
R:R:I262	R:R:S265	3.1	0	No	No	1	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:V44	R:R:Y107	6.31	0	No	Yes	6	9	2	1
R:R:I47	R:R:L103	8.56	0	No	No	9	9	2	1
R:R:R55	R:R:Y272	10.29	2	Yes	Yes	9	5	2	2
R:R:H276	R:R:R55	11.28	2	Yes	Yes	9	9	1	2
R:R:L103	R:R:Y107	9.38	2	No	Yes	9	9	1	1
R:R:L103	W:W:?2	8.28	2	No	Yes	9	0	1	0
R:R:Y107	W:W:?2	8.18	2	Yes	Yes	9	0	1	0
R:R:F191	W:W:?2	8.5	0	No	Yes	7	0	1	0
R:R:S194	W:W:?2	8.98	0	No	Yes	8	0	1	0
R:R:L195	R:R:L199	4.15	0	No	No	7	4	1	2
R:R:L195	W:W:?2	12.42	0	No	Yes	7	0	1	0
R:R:F198	R:R:I202	13.82	0	No	No	7	8	1	2
R:R:F198	W:W:?2	27.93	0	No	Yes	7	0	1	0
R:R:F237	R:R:V233	3.93	2	No	No	6	7	1	1
R:R:V233	W:W:?2	13.37	2	No	Yes	7	0	1	0
R:R:F236	R:R:F237	6.43	2	Yes	No	9	6	2	1
R:R:F236	R:R:Y272	6.19	2	Yes	Yes	9	5	2	2
R:R:F236	R:R:H276	12.44	2	Yes	Yes	9	9	2	1
R:R:F237	W:W:?2	35.22	2	No	Yes	6	0	1	0
R:R:H276	R:R:Y272	23.96	2	Yes	Yes	9	5	1	2
R:R:H276	W:W:?2	16.67	2	Yes	Yes	9	0	1	0
R:R:I111	R:R:Y107	3.63	0	No	Yes	9	9	2	1
R:R:F191	R:R:T192	1.3	0	No	No	7	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8XQT_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.93
Number of Linked Nodes	255
Number of Links	271
Number of Hubs	31
Number of Links mediated by Hubs	121
Number of Communities	6
Number of Nodes involved in Communities	42
Number of Links involved in Communities	56

Path Summary
Number Of Nodes in MetaPath	85
Number Of Links MetaPath	84
Number of Shortest Paths	38311
Length Of Smallest Path	3
Average Path Length	15.7281
Length of Longest Path	44
Minimum Path Strength	1.295
Average Path Strength	8.10224
Maximum Path Strength	31.575
Minimum Path Correlation	0.7
Average Path Correlation	0.930561
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.5641
Average % Of Corr. Nodes	43.3586
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	34.7949
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • cation binding • ion binding • metal ion binding • small molecule binding • hydrolase activity, acting on glycosyl bonds • alpha-sialidase activity • hydrolase activity, hydrolyzing O-glycosyl compounds • exo-alpha-sialidase activity • taste receptor activity • molecular transducer activity • transmembrane signaling receptor activity • signaling receptor activity • bitter taste receptor activity • G protein-coupled receptor activity • carbohydrate metabolic process • catabolic process • oligosaccharide catabolic process • oligosaccharide metabolic process • carbohydrate catabolic process • primary metabolic process • metabolic process • membrane lipid metabolic process • sphingolipid catabolic process • ceramide metabolic process • ganglioside catabolic process • carbohydrate derivative catabolic process • glycosphingolipid catabolic process • lipid catabolic process • glycolipid metabolic process • glycosphingolipid metabolic process • liposaccharide metabolic process • carbohydrate derivative metabolic process • sphingolipid metabolic process • membrane lipid catabolic process • glycolipid catabolic process • ceramide catabolic process • amide metabolic process • ganglioside metabolic process • lipid metabolic process • detection of chemical stimulus involved in sensory perception of bitter taste • detection of chemical stimulus involved in sensory perception of taste • detection of stimulus • detection of chemical stimulus • sensory perception of bitter taste • detection of stimulus involved in sensory perception • detection of chemical stimulus involved in sensory perception
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	CLR
PDB Residues	L:L:?1 W:W:?2
Environment Details	Open EMBL-EBI Page
Code	CLR
Name	Cholesterol
Synonyms	Cholesterin Cholesterol Cholest-5-en-3beta-ol (3β,14β,17α)-cholest-5-en-3-ol
Identifier
Formula	C27 H46 O
Molecular Weight	386.654
SMILES
PubChem	5997
Formal Charge	0
Total Atoms	74
Total Chiral Atoms	8
Total Bonds	77
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9NYV8
Sequence	>8XQT_nogp_Chain_R G G V I K S I F T F V L I V E F I I G N L G N S F I A L V N C I D W V K G R K I S S V D R I L T A L A I S R I S L V W L I F G S W C V S V F F P A L F A T E K M F R M L T N I W T V I N H F S V W L A T G L G T F Y F L K I A N F S N S I F L Y L K W R V K K V V L V L L L V T S V F L F L N I A L I N I H I N A S I N G F T R F S S L I V L T S T V F I F I P F T L S L A M F L L L I F S M W K H R K K M Q H T V R G V K S V I T F F L L Y A I F S L S F F I S V W T S E R L E E N L I I L S Q V M G M A Y P S C H S C V L I L G N K K L R Q A S L S V L L W L R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8RQL	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Flufenamic acid	Flufenamic acid	chim(NtGi1-Gt3)/β1/γ2	3.03	2024-11-27	10.1038/s41467-024-54157-6
	8RQL (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Flufenamic acid	Flufenamic acid		3.03	2024-11-27	10.1038/s41467-024-54157-6
	8XQT	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Cholesterol	Gi1/β1/γ1	2.94	2024-07-10	10.1038/s41586-024-07569-9
	8XQT (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Cholesterol		2.94	2024-07-10	10.1038/s41586-024-07569-9
	8XQS	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Flufenamic acid	Gi1/β1/γ1	3.3	2024-07-10	10.1038/s41586-024-07569-9
	8XQS (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Flufenamic acid		3.3	2024-07-10	10.1038/s41586-024-07569-9
	8XQO	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A	Gi1/β1/γ1	2.77	2024-07-10	10.1038/s41586-024-07569-9
	8XQO (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A		2.77	2024-07-10	10.1038/s41586-024-07569-9
	8XQN	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A	Gi1/β1/γ1	3.05	2024-07-10	10.1038/s41586-024-07569-9
	8XQN (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A		3.05	2024-07-10	10.1038/s41586-024-07569-9
	8XQR	T2	Sensory	Taste2	TAS2R14	Homo sapiens	-	Flufenamic acid	Gt3/β1/γ1	3.2	2024-07-10	10.1038/s41586-024-07569-9
	8XQR (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	-	Flufenamic acid		3.2	2024-07-10	10.1038/s41586-024-07569-9
	8XQP	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A	Gt3/β1/γ1	3.29	2024-07-10	10.1038/s41586-024-07569-9
	8XQP (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A		3.29	2024-07-10	10.1038/s41586-024-07569-9
	8XQL	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A	Gt3/β1/γ1	2.99	2024-07-10	10.1038/s41586-024-07569-9
	8XQL (No Gprot)	T2	Sensory	Taste2	TAS2R14	Homo sapiens	Cholesterol	Aristolochic acid A		2.99	2024-07-10	10.1038/s41586-024-07569-9

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