CodeCLR
NameCholesterol
Synonyms
  • Cholest-5-en-3beta-ol
  • Cholesterin
  • (3β,14β,17α)-cholest-5-en-3-ol
  • Cholesterol
Identifier(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
FormulaC27 H46 O
Molecular Weight386.654
SMILESCC(C)CCC[C@@H](C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C
PubChem5997
Formal Charge0
Total Atoms74
Total Chiral Atoms8
Total Bonds77
Total Aromatic Bonds0
Networks13
 missing image

This ligand is also present in the following 13 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
5L7D F Protein Frizzled SMO Homo sapiens - Cholesterol - 3.2 2016-07-20 10.1038/nature18934

A 2D representation of the interactions of CLR in 5L7D
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D95 R:R:S96 5.89 1 Yes No 5 6 1 2
R:R:D95 R:R:K105 13.83 1 Yes Yes 5 4 1 1
R:R:D95 R:R:Y130 11.49 1 Yes Yes 5 7 1 2
R:R:D95 R:R:F166 11.94 1 Yes Yes 5 6 1 2
R:R:D95 W:W:?2 8.17 1 Yes Yes 5 0 1 0
R:R:E101 R:R:S96 8.62 0 No No 5 6 2 2
R:R:E101 R:R:K105 5.4 0 No Yes 5 4 2 1
R:R:K105 R:R:Y130 5.97 1 Yes Yes 4 7 1 2
R:R:K105 W:W:?2 5.66 1 Yes Yes 4 0 1 0
R:R:L108 W:W:?2 5.56 0 No Yes 5 0 1 0
R:R:L126 R:R:W109 11.39 0 No Yes 9 7 2 1
R:R:W109 R:R:Y130 6.75 0 Yes Yes 7 7 1 2
R:R:L167 R:R:W109 4.56 1 No Yes 7 7 2 1
R:R:W109 W:W:?2 44.59 0 Yes Yes 7 0 1 0
R:R:L112 W:W:?2 12.51 0 No Yes 8 0 1 0
R:R:D209 R:R:I156 5.6 1 Yes No 4 5 2 1
R:R:I156 W:W:?2 7.16 0 No Yes 5 0 1 0
R:R:E160 R:R:R485 4.65 1 No Yes 4 5 2 2
R:R:E160 R:R:L489 10.6 1 No No 4 4 2 1
H:H:?2 R:R:E160 14.18 1 Yes No 0 4 1 2
R:R:R161 W:W:?2 21.95 1 No Yes 5 0 1 0
H:H:?2 R:R:R161 6.5 1 Yes No 0 5 1 1
R:R:F166 R:R:L167 6.09 1 Yes No 6 7 2 2
R:R:D209 R:R:R485 4.76 1 Yes Yes 4 5 2 2
R:R:L489 R:R:R485 4.86 1 No Yes 4 5 1 2
R:R:L489 W:W:?2 5.56 1 No Yes 4 0 1 0
R:R:A492 W:W:?2 7.91 0 No Yes 5 0 1 0
H:H:?2 R:R:N493 28.17 1 Yes No 0 5 1 2
R:R:I496 W:W:?2 4.3 0 No Yes 4 0 1 0
H:H:?2 W:W:?2 7.44 1 Yes Yes 0 0 1 0
R:R:G111 R:R:I496 1.76 0 No No 5 4 2 1
R:R:G497 R:R:L108 1.71 0 No No 3 5 2 1
R:R:I496 R:R:T495 1.52 0 No No 4 4 1 2
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub4.00
Average Interaction Strength11.89
Average Nodes In Shell25.00
Average Hubs In Shell9.00
Average Links In Shell33.00
Average Links Mediated by Hubs In Shell28.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6D35 F Protein Frizzled SMO Xenopus laevis - Cholesterol - 3.9 2018-05-23 10.1016/j.cell.2018.04.029

A 2D representation of the interactions of CLR in 6D35
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D68 R:R:S69 4.42 2 Yes Yes 6 7 1 2
R:R:D68 R:R:K78 4.15 2 Yes No 6 5 1 2
R:R:D68 R:R:Y103 11.49 2 Yes Yes 6 7 1 2
R:R:D68 R:R:F139 11.94 2 Yes Yes 6 8 1 2
R:R:D68 W:W:?3 6.81 2 Yes Yes 6 0 1 0
R:R:K78 R:R:S69 4.59 2 No Yes 5 7 2 2
R:R:K78 R:R:Y103 5.97 2 No Yes 5 7 2 2
R:R:L81 W:W:?3 8.34 0 No Yes 4 0 1 0
R:R:I95 R:R:W82 3.52 2 Yes Yes 8 7 2 1
R:R:L99 R:R:W82 15.94 2 No Yes 9 7 2 1
R:R:W82 R:R:Y103 11.58 2 Yes Yes 7 7 1 2
R:R:V130 R:R:W82 3.68 2 No Yes 7 7 1 1
R:R:L140 R:R:W82 3.42 2 Yes Yes 7 7 2 1
R:R:W82 W:W:?3 22.87 2 Yes Yes 7 0 1 0
R:R:I95 R:R:L99 9.99 2 Yes No 8 9 2 2
R:R:I95 R:R:W136 3.52 2 Yes Yes 8 9 2 2
R:R:F139 R:R:Y103 9.28 2 Yes Yes 8 7 2 2
R:R:I129 W:W:?3 2.87 0 No Yes 6 0 1 0
R:R:V130 R:R:W136 18.39 2 No Yes 7 9 1 2
R:R:V130 W:W:?3 4.49 2 No Yes 7 0 1 0
R:R:E133 W:W:?3 18.62 0 No Yes 4 0 1 0
R:R:R134 W:W:?3 10.98 0 No Yes 5 0 1 0
R:R:P137 R:R:W136 5.4 2 Yes Yes 9 9 1 2
R:R:L140 R:R:W136 4.56 2 Yes Yes 7 9 2 2
R:R:F139 R:R:P137 7.22 2 Yes Yes 8 9 2 1
R:R:L140 R:R:P137 14.78 2 Yes Yes 7 9 2 1
R:R:P137 W:W:?3 4.95 2 Yes Yes 9 0 1 0
R:R:F139 R:R:L140 7.31 2 Yes Yes 8 7 2 2
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub3.00
Average Interaction Strength9.99
Average Nodes In Shell17.00
Average Hubs In Shell10.00
Average Links In Shell28.00
Average Links Mediated by Hubs In Shell28.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6O3C F Protein Frizzled SMO Mus musculus SAG21k Cholesterol - 2.8 2019-07-03 10.1038/s41586-019-1355-4

A 2D representation of the interactions of CLR in 6O3C
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:I238 R:R:W285 4.7 0 No Yes 7 8 2 1
R:R:F278 R:R:T532 5.19 0 No No 7 7 2 1
R:R:V325 R:R:W285 3.68 1 No Yes 7 8 2 1
R:R:I393 R:R:W285 15.27 1 No Yes 8 8 2 1
R:R:M529 R:R:W285 12.8 1 No Yes 5 8 1 1
R:R:F530 R:R:W285 5.01 1 Yes Yes 8 8 2 1
R:R:W285 W:W:?1 5.72 1 Yes Yes 8 0 1 0
R:R:I393 R:R:V325 4.61 1 No No 8 7 2 2
R:R:F395 R:R:Y326 5.16 1 Yes Yes 8 9 1 2
R:R:L329 W:W:?1 5.56 0 No Yes 6 0 1 0
R:R:I412 R:R:V333 4.61 1 No No 7 6 1 1
R:R:V333 R:R:V415 4.81 1 No No 6 5 1 2
R:R:V333 W:W:?1 5.98 1 No Yes 6 0 1 0
R:R:D386 R:R:Y398 5.75 0 No Yes 9 5 2 1
R:R:D388 R:R:S391 8.83 1 Yes No 8 7 2 2
R:R:D388 R:R:Y398 5.75 1 Yes Yes 8 5 2 1
L:L:?1 R:R:D388 6.19 1 Yes Yes 0 8 2 2
R:R:S391 R:R:Y398 5.09 1 No Yes 7 5 2 1
R:R:F395 R:R:V396 5.24 1 Yes No 8 8 1 2
R:R:F395 R:R:Y398 5.16 1 Yes Yes 8 5 1 1
R:R:F395 W:W:?1 12.23 1 Yes Yes 8 0 1 0
L:L:?1 R:R:Y398 13.76 1 Yes Yes 0 5 2 1
R:R:Y398 W:W:?1 5.88 1 Yes Yes 5 0 1 0
R:R:H474 R:R:R404 16.93 1 Yes No 7 9 1 2
R:R:H474 R:R:V408 4.15 1 Yes No 7 6 1 2
R:R:H474 R:R:L409 18 1 Yes No 7 8 1 2
R:R:I412 R:R:V467 4.61 1 No No 7 7 1 2
R:R:I412 W:W:?1 10.03 1 No Yes 7 0 1 0
R:R:F466 R:R:T532 6.49 0 Yes No 6 7 2 1
R:R:H474 R:R:T470 4.11 1 Yes No 7 8 1 1
R:R:N525 R:R:T470 4.39 1 No No 8 8 1 1
R:R:T470 W:W:?1 14.8 1 No Yes 8 0 1 0
R:R:C473 R:R:N525 12.6 0 No No 7 8 2 1
R:R:F478 R:R:H474 4.53 0 Yes Yes 7 7 2 1
R:R:H474 W:W:?1 3.87 1 Yes Yes 7 0 1 0
R:R:N525 W:W:?1 15.16 1 No Yes 8 0 1 0
R:R:F530 R:R:L526 3.65 1 Yes No 8 7 2 1
R:R:L526 W:W:?1 4.17 0 No Yes 7 0 1 0
R:R:F530 R:R:M529 7.46 1 Yes No 8 5 2 1
R:R:M529 W:W:?1 17.03 1 No Yes 5 0 1 0
R:R:T532 W:W:?1 13.32 0 No Yes 7 0 1 0
R:R:A463 W:W:?1 1.58 0 No Yes 6 0 1 0
StatisticsValue
Average Number Of Links13.00
Average Number Of Links With An Hub4.00
Average Interaction Strength8.87
Average Nodes In Shell33.00
Average Hubs In Shell11.00
Average Links In Shell42.00
Average Links Mediated by Hubs In Shell35.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of CLR in 6O3C
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D99 R:R:S100 4.42 2 Yes No 6 7 1 2
R:R:D99 R:R:K109 11.06 2 Yes Yes 6 4 1 1
R:R:D99 R:R:Y134 11.49 2 Yes Yes 6 7 1 2
R:R:D99 R:R:F170 11.94 2 Yes Yes 6 6 1 2
R:R:D99 W:W:?2 6.81 2 Yes Yes 6 0 1 0
R:R:E105 R:R:S100 7.19 0 No No 5 7 2 2
R:R:E105 R:R:K109 4.05 0 No Yes 5 4 2 1
R:R:K109 R:R:Y134 5.97 2 Yes Yes 4 7 1 2
R:R:K109 W:W:?2 4.25 2 Yes Yes 4 0 1 0
R:R:L112 W:W:?2 9.73 2 No Yes 4 0 1 0
H:H:?2 R:R:L112 4.94 2 Yes No 0 4 1 1
R:R:L130 R:R:W113 13.67 0 No Yes 9 7 2 1
R:R:W113 R:R:Y134 7.72 2 Yes Yes 7 7 1 2
R:R:V161 R:R:W113 3.68 2 No Yes 6 7 1 1
R:R:P168 R:R:W113 4.05 2 No Yes 9 7 2 1
R:R:W113 W:W:?2 34.3 2 Yes Yes 7 0 1 0
R:R:L116 W:W:?2 11.12 0 No Yes 9 0 1 0
R:R:F170 R:R:Y134 5.16 2 Yes Yes 6 7 2 2
R:R:V161 R:R:W167 18.39 2 No Yes 6 9 1 2
R:R:V161 W:W:?2 4.49 2 No Yes 6 0 1 0
R:R:E164 R:R:L493 11.93 2 No No 4 4 1 1
R:R:E164 W:W:?2 3.99 2 No Yes 4 0 1 0
R:R:R165 W:W:?2 13.42 2 No Yes 4 0 1 0
H:H:?2 R:R:R165 4.33 2 Yes No 0 4 1 1
R:R:F170 R:R:P168 10.11 2 Yes No 6 9 2 2
R:R:L493 R:R:R489 3.64 2 No Yes 4 5 1 2
R:R:L493 W:W:?2 4.17 2 No Yes 4 0 1 0
R:R:A496 W:W:?2 4.75 0 No Yes 5 0 1 0
H:H:?2 R:R:N497 29.4 2 Yes No 0 5 1 2
H:H:?2 W:W:?2 6.2 2 Yes Yes 0 0 1 0
R:R:G115 R:R:I500 3.53 0 No No 6 3 1 2
R:R:G115 W:W:?2 1.72 0 No Yes 6 0 1 0
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub4.00
Average Interaction Strength8.75
Average Nodes In Shell23.00
Average Hubs In Shell9.00
Average Links In Shell32.00
Average Links Mediated by Hubs In Shell29.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6XBJ F Protein Frizzled SMO Homo sapiens - Cholesterol Gi1/Beta1/Gamma2 3.88 2020-09-30 10.1038/s41589-020-0646-2

A 2D representation of the interactions of CLR in 6XBJ
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:I234 R:R:W281 4.7 1 No Yes 7 7 2 1
R:R:F526 R:R:I234 3.77 1 Yes No 9 7 2 2
R:R:V321 R:R:W281 6.13 0 No Yes 8 7 2 1
R:R:I389 R:R:W281 7.05 0 No Yes 9 7 2 1
R:R:M525 R:R:W281 6.98 1 Yes Yes 5 7 1 1
R:R:F526 R:R:W281 9.02 1 Yes Yes 9 7 2 1
R:R:W281 W:W:?1 4.57 1 Yes Yes 7 0 1 0
R:R:F391 R:R:V321 3.93 1 Yes No 8 8 1 2
R:R:M326 R:R:Y322 5.99 1 Yes Yes 8 9 2 2
R:R:F391 R:R:Y322 5.16 1 Yes Yes 8 9 1 2
R:R:L325 R:R:M525 4.24 1 No Yes 5 5 1 1
R:R:L325 W:W:?1 12.51 1 No Yes 5 0 1 0
R:R:M326 R:R:V329 3.04 1 Yes Yes 8 6 2 1
R:R:I408 R:R:V329 4.61 1 No Yes 7 6 1 1
R:R:V329 R:R:V411 4.81 1 Yes No 6 5 1 2
R:R:V329 W:W:?1 5.98 1 Yes Yes 6 0 1 0
R:R:F332 R:R:T336 7.78 1 Yes No 9 7 1 2
R:R:F332 R:R:F455 6.43 1 Yes Yes 9 8 1 2
R:R:F332 R:R:M532 9.95 1 Yes No 9 8 1 2
R:R:F332 W:W:?1 3.67 1 Yes Yes 9 0 1 0
R:R:D382 R:R:Y394 12.64 0 No Yes 9 5 2 1
R:R:R384 R:R:Y394 10.29 1 Yes Yes 8 5 2 1
R:R:F391 R:R:Y394 4.13 1 Yes Yes 8 5 1 1
R:R:F391 W:W:?1 3.67 1 Yes Yes 8 0 1 0
R:R:Y394 W:W:?1 7.06 1 Yes Yes 5 0 1 0
R:R:V404 W:W:?1 8.97 0 No Yes 7 0 1 0
R:R:H470 R:R:L405 9 1 Yes No 7 8 1 2
R:R:I408 R:R:V463 3.07 1 No No 7 7 1 1
R:R:I408 W:W:?1 11.46 1 No Yes 7 0 1 0
R:R:L412 R:R:V463 7.45 0 No No 7 7 2 1
R:R:F455 R:R:M532 4.98 1 Yes No 8 8 2 2
R:R:F462 R:R:T528 5.19 0 Yes No 7 7 2 1
R:R:V463 W:W:?1 4.49 1 No Yes 7 0 1 0
R:R:H470 R:R:T466 6.85 1 Yes No 7 8 1 1
R:R:N521 R:R:T466 2.92 1 Yes No 8 8 1 1
R:R:T466 W:W:?1 14.8 1 No Yes 8 0 1 0
R:R:C469 R:R:N521 11.02 0 No Yes 7 8 2 1
R:R:F474 R:R:H470 3.39 0 Yes Yes 6 7 2 1
R:R:H470 R:R:N521 6.38 1 Yes Yes 7 8 1 1
R:R:H470 W:W:?1 19.36 1 Yes Yes 7 0 1 0
R:R:N521 W:W:?1 5.51 1 Yes Yes 8 0 1 0
R:R:F526 R:R:M525 3.73 1 Yes Yes 9 5 2 1
R:R:M525 W:W:?1 14.19 1 Yes Yes 5 0 1 0
R:R:T528 W:W:?1 22.2 0 No Yes 7 0 1 0
R:R:E518 W:W:?1 2.66 0 No Yes 7 0 1 0
R:R:A459 W:W:?1 1.58 0 No Yes 7 0 1 0
StatisticsValue
Average Number Of Links16.00
Average Number Of Links With An Hub8.00
Average Interaction Strength8.92
Average Nodes In Shell34.00
Average Hubs In Shell16.00
Average Links In Shell46.00
Average Links Mediated by Hubs In Shell44.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6XBK F Protein Frizzled SMO Homo sapiens - Cholesterol Gi1/Beta1/Gamma2 3.24 2020-09-30 10.1038/s41589-020-0646-2

A 2D representation of the interactions of CLR in 6XBK
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:F222 R:R:N219 3.62 2 Yes No 6 7 1 2
R:R:D384 R:R:N219 8.08 2 Yes No 8 7 1 2
R:R:E226 R:R:F222 7 0 No Yes 8 6 2 1
R:R:F222 R:R:H227 3.39 2 Yes Yes 6 7 1 2
R:R:F222 R:R:V386 9.18 2 Yes Yes 6 5 1 2
R:R:F222 R:R:P513 8.67 2 Yes No 6 8 1 2
R:R:E518 R:R:F222 4.66 2 Yes Yes 7 6 1 1
R:R:F222 W:W:?1 4.89 2 Yes Yes 6 0 1 0
R:R:E226 R:R:L515 6.63 0 No Yes 8 5 2 2
R:R:H227 R:R:V386 8.3 2 Yes Yes 7 5 2 2
R:R:I234 R:R:M230 5.83 2 Yes Yes 7 7 2 2
R:R:M230 R:R:V386 3.04 2 Yes Yes 7 5 2 2
R:R:L515 R:R:M230 5.65 0 Yes Yes 5 7 2 2
R:R:L522 R:R:M230 2.83 2 Yes Yes 7 7 1 2
R:R:L522 R:R:Y233 4.69 2 Yes Yes 7 6 1 2
R:R:I234 R:R:W281 3.52 2 Yes Yes 7 7 2 2
R:R:I234 R:R:L522 2.85 2 Yes Yes 7 7 2 1
R:R:V321 R:R:W281 4.9 2 No Yes 8 7 2 2
R:R:S387 R:R:W281 2.47 2 Yes Yes 8 7 1 2
R:R:L522 R:R:W281 3.42 2 Yes Yes 7 7 1 2
R:R:M525 R:R:W281 6.98 0 No Yes 5 7 1 2
R:R:F526 R:R:W281 6.01 2 Yes Yes 9 7 2 2
R:R:F318 R:R:Y322 8.25 2 Yes Yes 9 9 2 2
R:R:F318 R:R:F391 2.14 2 Yes Yes 9 8 2 1
R:R:F318 R:R:V392 3.93 2 Yes Yes 9 9 2 2
R:R:F391 R:R:V321 2.62 2 Yes No 8 8 1 2
R:R:F391 R:R:Y322 6.19 2 Yes Yes 8 9 1 2
R:R:V392 R:R:Y322 2.52 2 Yes Yes 9 9 2 2
R:R:L325 R:R:M525 5.65 0 No No 5 5 2 1
R:R:I408 R:R:V329 4.61 0 No No 7 6 1 2
R:R:D382 R:R:Y394 10.34 0 No Yes 9 5 2 1
R:R:D384 R:R:V386 4.38 2 Yes Yes 8 5 1 2
R:R:D384 R:R:S387 7.36 2 Yes Yes 8 8 1 1
R:R:D384 R:R:Y394 10.34 2 Yes Yes 8 5 1 1
R:R:D384 W:W:?1 9.54 2 Yes Yes 8 0 1 0
R:R:S387 R:R:Y394 2.54 2 Yes Yes 8 5 1 1
R:R:S387 W:W:?1 9.04 2 Yes Yes 8 0 1 0
R:R:F391 R:R:V392 2.62 2 Yes Yes 8 9 1 2
R:R:F391 R:R:Y394 5.16 2 Yes Yes 8 5 1 1
R:R:F391 W:W:?1 4.89 2 Yes Yes 8 0 1 0
R:R:Y394 W:W:?1 18.83 2 Yes Yes 5 0 1 0
R:R:R400 R:R:Y397 2.06 2 No No 9 3 1 2
R:R:F474 R:R:Y397 7.22 2 Yes No 6 3 2 2
R:R:F474 R:R:R400 3.21 2 Yes No 6 9 2 1
R:R:R400 W:W:?1 15.85 2 No Yes 9 0 1 0
R:R:H470 R:R:V404 4.15 2 Yes No 7 7 1 2
R:R:H470 R:R:L405 9 2 Yes No 7 8 1 2
R:R:I408 R:R:V463 3.07 0 No No 7 7 1 2
R:R:I408 W:W:?1 4.3 0 No Yes 7 0 1 0
R:R:H470 R:R:T466 5.48 2 Yes No 7 8 1 1
R:R:N521 R:R:T466 4.39 2 Yes No 8 8 1 1
R:R:T466 W:W:?1 8.88 2 No Yes 8 0 1 0
R:R:C469 R:R:N521 9.45 0 No Yes 7 8 2 1
R:R:F474 R:R:H470 2.26 2 Yes Yes 6 7 2 1
R:R:H470 R:R:N521 7.65 2 Yes Yes 7 8 1 1
R:R:H470 W:W:?1 16.78 2 Yes Yes 7 0 1 0
R:R:D473 R:R:W480 2.23 0 No Yes 8 9 1 2
R:R:D473 R:R:V517 2.92 0 No Yes 8 6 1 2
R:R:D473 W:W:?1 2.72 0 No Yes 8 0 1 0
R:R:P513 R:R:W480 28.38 0 No Yes 8 9 2 2
R:R:E518 R:R:L515 5.3 2 Yes Yes 7 5 1 2
R:R:E518 R:R:V517 5.7 2 Yes Yes 7 6 1 2
R:R:E518 W:W:?1 15.96 2 Yes Yes 7 0 1 0
R:R:N521 W:W:?1 6.89 2 Yes Yes 8 0 1 0
R:R:F526 R:R:L522 2.44 2 Yes Yes 9 7 2 1
R:R:L522 W:W:?1 2.78 2 Yes Yes 7 0 1 0
R:R:M525 W:W:?1 4.26 0 No Yes 5 0 1 0
StatisticsValue
Average Number Of Links14.00
Average Number Of Links With An Hub9.00
Average Interaction Strength8.97
Average Nodes In Shell41.00
Average Hubs In Shell24.00
Average Links In Shell67.00
Average Links Mediated by Hubs In Shell63.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6XBL F Protein Frizzled SMO Homo sapiens SAG Cholesterol Gi1/Beta1/Gamma2 3.96 2020-09-30 10.1038/s41589-020-0646-2

A 2D representation of the interactions of CLR in 6XBL
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L221 R:R:N219 5.49 1 Yes Yes 6 7 2 2
L:L:?1 R:R:N219 12.94 1 Yes Yes 0 7 1 2
R:R:F484 R:R:L221 2.44 1 Yes Yes 6 6 2 2
R:R:L221 R:R:P513 6.57 1 Yes Yes 6 8 2 2
L:L:?1 R:R:L221 1.86 1 Yes Yes 0 6 1 2
R:R:I234 R:R:W281 7.05 1 Yes Yes 7 7 2 1
R:R:F526 R:R:I234 2.51 1 Yes Yes 9 7 2 2
R:R:F274 R:R:L325 2.44 0 Yes No 9 5 2 1
R:R:F274 R:R:T528 2.59 0 Yes No 9 7 2 1
R:R:V321 R:R:W281 4.9 0 No Yes 8 7 2 1
R:R:S387 R:R:W281 2.47 1 Yes Yes 8 7 2 1
R:R:I389 R:R:W281 5.87 1 No Yes 9 7 2 1
R:R:L522 R:R:W281 4.56 0 No Yes 7 7 2 1
R:R:M525 R:R:W281 9.31 1 No Yes 5 7 1 1
R:R:F526 R:R:W281 2 1 Yes Yes 9 7 2 1
R:R:W281 W:W:?1 4.57 1 Yes Yes 7 0 1 0
R:R:L303 R:R:M301 4.24 1 No No 3 4 2 2
L:L:?1 R:R:M301 5.71 1 Yes No 0 4 1 2
L:L:?1 R:R:L303 1.86 1 Yes No 0 3 1 2
R:R:F318 R:R:Y322 7.22 1 Yes Yes 9 9 2 2
R:R:F318 R:R:F391 6.43 1 Yes Yes 9 8 2 1
R:R:F318 R:R:V392 5.24 1 Yes Yes 9 9 2 2
R:R:F391 R:R:Y322 4.13 1 Yes Yes 8 9 1 2
R:R:L325 R:R:M525 4.24 1 No No 5 5 1 1
R:R:L325 W:W:?1 2.78 1 No Yes 5 0 1 0
R:R:F332 R:R:T336 5.19 1 Yes No 9 7 1 2
R:R:F332 R:R:V411 2.62 1 Yes No 9 5 1 2
R:R:F332 R:R:F455 6.43 1 Yes No 9 8 1 2
R:R:F332 R:R:M532 7.46 1 Yes No 9 8 1 2
R:R:F332 W:W:?1 2.45 1 Yes Yes 9 0 1 0
R:R:D382 R:R:Y394 6.9 1 Yes Yes 9 5 2 1
R:R:D382 R:R:K395 2.77 1 Yes Yes 9 3 2 2
L:L:?1 R:R:D382 1.83 1 Yes Yes 0 9 1 2
R:R:D384 R:R:S387 11.78 1 Yes Yes 8 8 2 2
R:R:D384 R:R:Y394 16.09 1 Yes Yes 8 5 2 1
L:L:?1 R:R:D384 1.83 1 Yes Yes 0 8 1 2
R:R:I389 R:R:S387 4.64 1 No Yes 9 8 2 2
R:R:F391 R:R:V392 3.93 1 Yes Yes 8 9 1 2
R:R:F391 R:R:Y394 8.25 1 Yes Yes 8 5 1 1
R:R:F391 W:W:?1 14.67 1 Yes Yes 8 0 1 0
L:L:?1 R:R:Y394 8.68 1 Yes Yes 0 5 1 1
R:R:Y394 W:W:?1 7.06 1 Yes Yes 5 0 1 0
R:R:E481 R:R:K395 4.05 1 No Yes 5 3 2 2
L:L:?1 R:R:K395 10.44 1 Yes Yes 0 3 1 2
R:R:H470 R:R:R400 3.39 1 Yes Yes 7 9 1 2
R:R:D473 R:R:R400 10.72 1 No Yes 8 9 2 2
R:R:F474 R:R:R400 7.48 1 Yes Yes 6 9 2 2
R:R:H470 R:R:V404 12.45 1 Yes No 7 7 1 1
R:R:V404 W:W:?1 5.98 1 No Yes 7 0 1 0
R:R:I408 R:R:V463 4.61 1 No No 7 7 1 1
R:R:I408 W:W:?1 10.03 1 No Yes 7 0 1 0
R:R:L412 R:R:V463 8.94 0 No No 7 7 2 1
R:R:F455 R:R:M532 4.98 1 No No 8 8 2 2
R:R:F462 R:R:T528 7.78 0 Yes No 7 7 2 1
R:R:V463 W:W:?1 2.99 1 No Yes 7 0 1 0
R:R:H470 R:R:T466 6.85 1 Yes No 7 8 1 1
R:R:T466 W:W:?1 2.96 1 No Yes 8 0 1 0
R:R:C469 R:R:N521 11.02 0 No No 7 8 2 1
R:R:F474 R:R:H470 7.92 1 Yes Yes 6 7 2 1
R:R:H470 R:R:N521 2.55 1 Yes No 7 8 1 1
R:R:H470 W:W:?1 10.33 1 Yes Yes 7 0 1 0
R:R:D473 R:R:W480 2.23 1 No Yes 8 9 2 2
L:L:?1 R:R:D473 11.87 1 Yes No 0 8 1 2
R:R:P513 R:R:W480 14.86 1 Yes Yes 8 9 2 2
L:L:?1 R:R:W480 3.83 1 Yes Yes 0 9 1 2
L:L:?1 R:R:E481 8.92 1 Yes No 0 5 1 2
L:L:?1 R:R:F484 13.94 1 Yes Yes 0 6 1 2
L:L:?1 R:R:P513 3.32 1 Yes Yes 0 8 1 2
L:L:?1 R:R:E518 8.92 1 Yes No 0 7 1 2
R:R:N521 W:W:?1 5.51 1 No Yes 8 0 1 0
R:R:M525 W:W:?1 18.45 1 No Yes 5 0 1 0
R:R:T528 W:W:?1 19.24 0 No Yes 7 0 1 0
L:L:?1 W:W:?1 2.81 1 Yes Yes 0 0 1 0
StatisticsValue
Average Number Of Links14.00
Average Number Of Links With An Hub6.00
Average Interaction Strength7.84
Average Nodes In Shell47.00
Average Hubs In Shell25.00
Average Links In Shell73.00
Average Links Mediated by Hubs In Shell67.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7F61 A Amine Histamine H3 Homo sapiens PF-03654746 Cholesterol - 2.6 2022-10-26 10.1038/s41467-022-33880-y

A 2D representation of the interactions of CLR in 7F61
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:E395 R:R:R27 8.14 1 Yes No 6 2 1 2
R:R:F29 R:R:L37 7.31 0 No No 5 5 2 1
R:R:L40 W:W:?1 8.34 0 No Yes 5 0 1 0
R:R:M41 R:R:W399 8.14 0 No Yes 7 9 2 1
R:R:L44 W:W:?1 12.51 0 No Yes 7 0 1 0
R:R:W399 R:R:Y91 5.79 1 Yes Yes 9 8 1 2
R:R:W402 R:R:Y91 8.68 1 Yes Yes 8 8 2 2
L:L:?1 R:R:Y91 7.1 1 Yes Yes 0 8 2 2
R:R:D391 R:R:Y394 10.34 1 No Yes 2 4 2 2
R:R:D391 R:R:E395 5.2 1 No Yes 2 6 2 1
R:R:E395 R:R:Y394 5.61 1 Yes Yes 6 4 1 2
L:L:?1 R:R:E395 7.22 1 Yes Yes 0 6 2 1
R:R:E395 W:W:?1 10.64 1 Yes Yes 6 0 1 0
R:R:T396 W:W:?1 10.36 0 No Yes 5 0 1 0
R:R:W399 R:R:W402 10.31 1 Yes Yes 9 8 1 2
R:R:W399 W:W:?1 35.45 1 Yes Yes 9 0 1 0
R:R:L37 W:W:?1 2.78 0 No Yes 5 0 1 0
R:R:L43 W:W:?1 1.39 0 No Yes 4 0 1 0
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub2.00
Average Interaction Strength11.64
Average Nodes In Shell16.00
Average Hubs In Shell7.00
Average Links In Shell18.00
Average Links Mediated by Hubs In Shell17.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7ZI0 F Protein Frizzled SMO Homo sapiens SAG Cholesterol - 3 2022-06-15 10.1126/sciadv.abm5563

A 2D representation of the interactions of CLR in 7ZI0
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D95 R:R:S96 7.36 1 Yes No 5 6 1 2
R:R:D95 R:R:K105 13.83 1 Yes No 5 4 1 1
R:R:D95 R:R:Y130 11.49 1 Yes Yes 5 7 1 2
R:R:D95 R:R:F166 13.14 1 Yes Yes 5 6 1 2
R:R:D95 W:W:?2 6.81 1 Yes Yes 5 0 1 0
R:R:K105 R:R:Y130 5.97 1 No Yes 4 7 1 2
R:R:K105 W:W:?2 7.08 1 No Yes 4 0 1 0
R:R:L108 W:W:?2 8.34 0 No Yes 5 0 1 0
R:R:L126 R:R:W109 11.39 0 No Yes 9 7 2 1
R:R:W109 R:R:Y130 7.72 1 Yes Yes 7 7 1 2
R:R:P164 R:R:W109 4.05 1 Yes Yes 9 7 1 1
R:R:W109 W:W:?2 35.45 1 Yes Yes 7 0 1 0
R:R:L112 W:W:?2 9.73 0 No Yes 8 0 1 0
R:R:F166 R:R:Y130 4.13 1 Yes Yes 6 7 2 2
R:R:D209 R:R:I156 13.99 1 Yes No 4 5 2 1
R:R:I156 W:W:?2 7.16 0 No Yes 5 0 1 0
R:R:V157 R:R:W163 20.84 0 No Yes 6 8 1 2
R:R:V157 W:W:?2 4.49 0 No Yes 6 0 1 0
R:R:E160 R:R:R485 4.65 1 No Yes 4 5 2 2
R:R:E160 R:R:L489 13.25 1 No No 4 4 2 1
R:R:R161 W:W:?2 12.2 0 No Yes 5 0 1 0
R:R:L167 R:R:W163 4.56 1 No Yes 7 8 2 2
R:R:F166 R:R:P164 7.22 1 Yes Yes 6 9 2 1
R:R:L167 R:R:P164 6.57 1 No Yes 7 9 2 1
R:R:P164 W:W:?2 4.95 1 Yes Yes 9 0 1 0
R:R:F166 R:R:L167 4.87 1 Yes No 6 7 2 2
R:R:D209 R:R:R485 13.1 1 Yes Yes 4 5 2 2
R:R:L489 R:R:R485 8.5 1 No Yes 4 5 1 2
R:R:L489 W:W:?2 5.56 1 No Yes 4 0 1 0
R:R:A492 W:W:?2 7.91 0 No Yes 5 0 1 0
R:R:I496 W:W:?2 8.6 0 No Yes 4 0 1 0
R:R:N493 R:R:R161 2.41 0 No No 5 5 2 1
R:R:G111 R:R:I496 1.76 0 No No 5 4 2 1
R:R:G497 R:R:I496 1.76 0 No No 3 4 2 1
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub3.00
Average Interaction Strength9.86
Average Nodes In Shell25.00
Average Hubs In Shell9.00
Average Links In Shell34.00
Average Links Mediated by Hubs In Shell30.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8U4N A Protein Chemokine CXCR4 Homo sapiens - Cholesterol Gi1/Beta1/Gamma2 2.72 2024-03-13 10.1101/2024.02.09.579708

A 2D representation of the interactions of CLR in 8U4N
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L78 R:R:R70 6.07 0 No Yes 5 6 1 2
R:R:L78 W:W:?1 13.9 0 No Yes 5 0 1 0
R:R:H79 R:R:I126 3.98 2 Yes Yes 9 7 1 2
R:R:H79 R:R:V156 9.69 2 Yes Yes 9 5 1 2
R:R:H79 R:R:Y157 7.62 2 Yes No 9 7 1 1
R:R:H79 R:R:W161 7.41 2 Yes Yes 9 9 1 1
R:R:H79 W:W:?1 20.65 2 Yes Yes 9 0 1 0
R:R:V82 W:W:?1 4.49 0 No Yes 5 0 1 0
R:R:S122 R:R:W161 8.65 0 No Yes 7 9 2 1
R:R:I126 R:R:V160 4.61 0 Yes Yes 7 7 2 2
R:R:V156 R:R:Y157 6.31 2 Yes No 5 7 2 1
R:R:V156 R:R:V160 3.21 2 Yes Yes 5 7 2 2
R:R:Y157 W:W:?1 9.42 2 No Yes 7 0 1 0
R:R:V160 R:R:W161 7.36 2 Yes Yes 7 9 2 1
R:R:W161 W:W:?1 19.44 2 Yes Yes 9 0 1 0
StatisticsValue
Average Number Of Links5.00
Average Number Of Links With An Hub2.00
Average Interaction Strength13.58
Average Nodes In Shell11.00
Average Hubs In Shell7.00
Average Links In Shell15.00
Average Links Mediated by Hubs In Shell15.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8U4O A Protein Chemokine CXCR4 Homo sapiens CXCL12 Cholesterol Gi1/Beta1/Gamma2 3.29 2024-03-13 10.1101/2024.02.09.579708

A 2D representation of the interactions of CLR in 8U4O
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:Q66 R:R:R70 3.5 9 Yes No 4 6 2 1
R:R:D74 R:R:Q66 5.22 9 Yes Yes 8 4 2 2
R:R:D74 R:R:R70 4.76 9 Yes No 8 6 2 1
R:R:R70 W:W:?1 12.2 9 No Yes 6 0 1 0
R:R:H79 R:R:K75 2.62 0 Yes No 9 6 1 2
R:R:L78 W:W:?1 8.34 0 No Yes 5 0 1 0
R:R:H79 R:R:I126 5.3 0 Yes Yes 9 7 1 2
R:R:H79 R:R:V156 2.77 0 Yes Yes 9 5 1 2
R:R:H79 W:W:?1 7.74 0 Yes Yes 9 0 1 0
R:R:V82 W:W:?1 7.48 0 No Yes 5 0 1 0
R:R:V118 R:R:W161 2.45 0 No Yes 5 9 2 1
R:R:S122 R:R:V160 3.23 6 Yes Yes 7 7 2 2
R:R:S122 R:R:W161 8.65 6 Yes Yes 7 9 2 1
R:R:I126 R:R:V160 9.22 0 Yes Yes 7 7 2 2
R:R:V156 R:R:W161 2.45 6 Yes Yes 5 9 2 1
R:R:Y157 W:W:?1 14.12 0 No Yes 7 0 1 0
R:R:V160 R:R:W161 3.68 6 Yes Yes 7 9 2 1
R:R:W161 W:W:?1 9.15 6 Yes Yes 9 0 1 0
R:R:L165 W:W:?1 4.17 0 No Yes 3 0 1 0
R:R:I60 R:R:L78 1.43 0 No No 7 5 2 1
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub2.00
Average Interaction Strength9.03
Average Nodes In Shell17.00
Average Hubs In Shell9.00
Average Links In Shell20.00
Average Links Mediated by Hubs In Shell19.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8U4P A Protein Chemokine CXCR4 Homo sapiens AMD3100 Cholesterol Gi1/Beta1/Gamma2 3.15 2024-03-13 10.1101/2024.02.09.579708

A 2D representation of the interactions of CLR in 8U4P
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D74 R:R:M63 8.32 13 Yes Yes 8 6 2 2
R:R:L78 R:R:M63 2.83 0 No Yes 5 6 1 2
R:R:D74 R:R:R70 4.76 13 Yes No 8 6 2 1
R:R:R70 W:W:?1 7.32 0 No Yes 6 0 1 0
R:R:E153 R:R:K75 13.5 0 No No 7 6 2 1
R:R:K75 W:W:?1 5.66 0 No Yes 6 0 1 0
R:R:L78 W:W:?1 9.73 0 No Yes 5 0 1 0
R:R:H79 R:R:I126 3.98 20 Yes Yes 9 7 1 2
R:R:H79 R:R:V156 5.54 20 Yes No 9 5 1 2
R:R:H79 R:R:W161 6.35 20 Yes Yes 9 9 1 1
R:R:H79 W:W:?1 18.07 20 Yes Yes 9 0 1 0
R:R:S122 R:R:W161 7.41 0 No Yes 7 9 2 1
R:R:I126 R:R:V160 4.61 0 Yes Yes 7 7 2 2
R:R:Y157 W:W:?1 14.12 0 No Yes 7 0 1 0
R:R:V160 R:R:W161 8.58 0 Yes Yes 7 9 2 1
R:R:W161 W:W:?1 9.15 20 Yes Yes 9 0 1 0
StatisticsValue
Average Number Of Links6.00
Average Number Of Links With An Hub2.00
Average Interaction Strength10.67
Average Nodes In Shell14.00
Average Hubs In Shell7.00
Average Links In Shell16.00
Average Links Mediated by Hubs In Shell15.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8U4Q A Protein Chemokine CXCR4 Homo sapiens REGN7663-Fab Cholesterol Gi1/Beta1/Gamma2 3.36 2024-03-13 10.1101/2024.02.09.579708

A 2D representation of the interactions of CLR in 8U4Q
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:K75 R:R:R70 2.48 3 No No 6 6 1 1
R:R:R70 W:W:?1 4.88 3 No Yes 6 0 1 0
R:R:E153 R:R:K75 14.85 0 No No 7 6 2 1
R:R:K75 W:W:?1 4.25 3 No Yes 6 0 1 0
R:R:L78 W:W:?1 9.73 0 No Yes 5 0 1 0
R:R:H79 R:R:I126 2.65 3 Yes Yes 9 7 1 2
R:R:H79 R:R:V156 4.15 3 Yes Yes 9 5 1 2
R:R:H79 R:R:W161 6.35 3 Yes Yes 9 9 1 1
R:R:H79 W:W:?1 18.07 3 Yes Yes 9 0 1 0
R:R:V82 W:W:?1 5.98 0 No Yes 5 0 1 0
R:R:S122 R:R:W161 7.41 0 No Yes 7 9 2 1
R:R:I126 R:R:V160 4.61 0 Yes No 7 7 2 2
R:R:V156 R:R:Y157 7.57 3 Yes No 5 7 2 1
R:R:Y157 W:W:?1 9.42 0 No Yes 7 0 1 0
R:R:V160 R:R:W161 8.58 0 No Yes 7 9 2 1
R:R:W161 W:W:?1 9.15 3 Yes Yes 9 0 1 0
R:R:L165 W:W:?1 4.17 0 No Yes 3 0 1 0
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub2.00
Average Interaction Strength8.21
Average Nodes In Shell14.00
Average Hubs In Shell5.00
Average Links In Shell17.00
Average Links Mediated by Hubs In Shell15.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8U4R A Protein Chemokine CXCR4 Homo sapiens REGN7663-Fab Cholesterol - 3.1 2024-03-13 10.1101/2024.02.09.579708

A 2D representation of the interactions of CLR in 8U4R
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:I60 R:R:V82 3.07 0 Yes No 7 5 2 1
R:R:H79 R:R:I126 3.98 7 Yes No 9 7 1 2
R:R:H79 R:R:V156 4.15 7 Yes No 9 5 1 2
R:R:H79 R:R:Y157 6.53 7 Yes No 9 7 1 1
R:R:H79 R:R:W161 4.23 7 Yes Yes 9 9 1 1
R:R:H79 W:W:?1 18.07 7 Yes Yes 9 0 1 0
R:R:V82 W:W:?1 10.47 0 No Yes 5 0 1 0
R:R:L86 R:R:S119 3 0 No No 7 8 1 2
R:R:V118 W:W:?1 2.99 0 No Yes 5 0 1 0
R:R:S122 R:R:W161 7.41 0 No Yes 7 9 2 1
R:R:I126 R:R:V160 6.14 0 No Yes 7 7 2 2
R:R:V156 R:R:Y157 5.05 7 No No 5 7 2 1
R:R:V156 R:R:V160 3.21 7 No Yes 5 7 2 2
R:R:Y157 W:W:?1 10.59 7 No Yes 7 0 1 0
R:R:V160 R:R:W161 6.13 0 Yes Yes 7 9 2 1
R:R:W161 W:W:?1 19.44 7 Yes Yes 9 0 1 0
R:R:L165 W:W:?1 9.73 0 No Yes 3 0 1 0
R:R:L86 W:W:?1 2.78 0 No Yes 7 0 1 0
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub2.00
Average Interaction Strength10.58
Average Nodes In Shell14.00
Average Hubs In Shell5.00
Average Links In Shell18.00
Average Links Mediated by Hubs In Shell16.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub3.79
Average Interaction Strength9.91
Average Nodes In Shell23.64
Average Hubs In Shell10.93
Average Links In Shell32.79
Average Links Mediated by Hubs In Shell30.07

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)