psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C151	R:R:C37	7.28	Yes	No	9	8	9
2	R:R:K111	R:R:K38	7.18	No	No	0	3	4
3	R:R:K39	R:R:V64	4.55	No	No	0	6	5
4	R:R:K39	R:R:V112	3.04	No	Yes	0	6	8
5	R:R:K111	R:R:T40	7.51	No	No	0	3	3
6	R:R:S62	R:R:T41	7.99	Yes	No	6	8	6
7	R:R:T41	R:R:V64	6.35	No	No	6	6	5
8	R:R:T41	R:R:V112	4.76	No	Yes	6	6	8
9	R:R:C43	R:R:L60	3.17	No	No	0	9	4
10	R:R:C107	R:R:C43	7.28	No	No	0	9	9
11	R:R:E44	R:R:Q72	15.29	No	No	0	6	8
12	R:R:L60	R:R:P45	4.93	No	No	0	4	4
13	R:R:L46	R:R:N49	4.12	No	No	0	7	5
14	R:R:L46	R:R:L56	5.54	No	Yes	0	7	7
15	R:R:L46	R:R:T61	7.37	No	No	0	7	9
16	R:R:K47	R:R:Y48	7.17	No	No	0	4	4
17	R:R:K47	R:R:Q72	4.07	No	No	0	4	8
18	R:R:D73	R:R:K47	9.68	No	No	0	4	4
19	R:R:H76	R:R:Y48	16.33	No	No	0	4	4
20	R:R:L462	R:R:N49	10.98	No	No	0	4	5
21	R:R:I50	R:R:V55	3.07	No	No	5	5	4
22	R:R:D182	R:R:I50	11.2	No	No	0	5	5
23	R:R:I50	R:R:V183	3.07	No	No	5	5	7
24	R:R:C51	R:R:L56	4.76	No	Yes	3	9	7
25	R:R:C100	R:R:C51	7.28	No	No	0	9	9
26	R:R:C51	R:R:M104	6.48	No	No	3	9	6
27	R:R:L52	R:R:L79	4.15	No	No	0	6	9
28	R:R:L52	R:R:W92	9.11	No	Yes	0	6	9
29	R:R:E184	R:R:G53	4.91	No	No	0	5	8
30	R:R:F160	R:R:S54	13.21	Yes	No	0	8	5
31	R:R:V183	R:R:V55	3.21	No	No	5	7	4
32	R:R:A465	R:R:V55	5.09	No	No	0	6	4
33	R:R:L56	R:R:P57	3.28	Yes	Yes	3	7	7
34	R:R:L56	R:R:Y58	16.41	Yes	Yes	3	7	9
35	R:R:L56	R:R:M104	4.24	Yes	No	3	7	6
36	R:R:P57	R:R:Y58	5.56	Yes	Yes	3	7	9
37	R:R:I158	R:R:P57	6.77	No	Yes	3	5	7
38	R:R:I469	R:R:P57	5.08	Yes	Yes	3	4	7
39	R:R:K106	R:R:Y58	20.3	Yes	Yes	3	6	9
40	R:R:E154	R:R:Y58	3.37	No	Yes	3	5	9
41	R:R:Q72	R:R:T61	5.67	No	No	0	8	9
42	R:R:P105	R:R:T61	3.5	No	No	0	9	9
43	R:R:S62	R:R:V64	4.85	Yes	No	6	8	5
44	R:R:C107	R:R:S62	3.44	No	Yes	6	9	8
45	R:R:S62	R:R:V112	3.23	Yes	Yes	6	8	8
46	R:R:T63	R:R:V75	3.17	No	No	0	5	7
47	R:R:A66	R:R:S69	3.42	No	Yes	0	6	7
48	R:R:A66	R:R:Y103	4	No	Yes	0	6	7
49	R:R:E67	R:R:F139	9.33	No	Yes	2	5	8
50	R:R:E67	R:R:Y146	12.35	No	Yes	2	5	4
51	R:R:D68	R:R:S69	4.42	Yes	Yes	2	6	7
52	R:R:D68	R:R:K78	4.15	Yes	No	2	6	5
53	R:R:D68	R:R:Y103	11.49	Yes	Yes	2	6	7
54	R:R:D68	R:R:F139	11.94	Yes	Yes	2	6	8
55	R:R:D68	W:W:?3	6.81	Yes	Yes	2	6	0
56	R:R:E74	R:R:S69	4.31	No	Yes	2	5	7
57	R:R:S69	R:R:V75	3.23	Yes	No	0	7	7
58	R:R:K78	R:R:S69	4.59	No	Yes	2	5	7
59	R:R:S70	R:R:S71	3.26	No	No	2	3	6
60	R:R:E74	R:R:S70	10.06	No	No	2	5	3
61	R:R:D73	R:R:S71	2.94	No	No	0	4	6
62	R:R:E74	R:R:S71	7.19	No	No	2	5	6
63	R:R:L79	R:R:V75	2.98	No	No	0	9	7
64	R:R:H76	R:R:S80	5.58	No	No	0	4	3
65	R:R:K78	R:R:Y103	5.97	No	Yes	2	5	7
66	R:R:L79	R:R:Y103	7.03	No	Yes	0	9	7
67	R:R:L81	W:W:?3	8.34	No	Yes	0	4	0
68	R:R:I95	R:R:W82	3.52	Yes	Yes	2	8	7
69	R:R:L99	R:R:W82	15.94	No	Yes	2	9	7
70	R:R:W82	R:R:Y103	11.58	Yes	Yes	2	7	7
71	R:R:V130	R:R:W82	3.68	No	Yes	2	7	7
72	R:R:L140	R:R:W82	3.42	Yes	Yes	2	7	7
73	R:R:W82	W:W:?3	22.87	Yes	Yes	2	7	0
74	R:R:R86	R:R:S83	3.95	Yes	No	0	6	5
75	R:R:C91	R:R:L85	6.35	No	No	0	9	9
76	R:R:L85	R:R:W92	7.97	No	Yes	0	9	9
77	R:R:I95	R:R:L85	2.85	Yes	No	0	8	9
78	R:R:R86	R:R:W92	6	Yes	Yes	0	6	9
79	R:R:C127	R:R:C91	7.28	No	No	0	9	9
80	R:R:R96	R:R:W92	23.99	No	Yes	0	8	9
81	R:R:I95	R:R:L99	9.99	Yes	No	2	8	9
82	R:R:C127	R:R:I95	6.55	No	Yes	0	9	8
83	R:R:I95	R:R:W136	3.52	Yes	Yes	2	8	9
84	R:R:F160	R:R:R96	20.31	Yes	No	0	8	8
85	R:R:E184	R:R:R96	8.14	No	No	0	5	8
86	R:R:L119	R:R:P97	3.28	No	No	0	6	7
87	R:R:F160	R:R:P97	2.89	Yes	No	0	8	7
88	R:R:L98	R:R:T123	8.84	No	No	0	8	8
89	R:R:F147	R:R:L98	4.87	Yes	No	0	8	8
90	R:R:C100	R:R:F160	4.19	No	Yes	0	9	8
91	R:R:A101	R:R:P115	3.74	No	No	0	8	9
92	R:R:A101	R:R:V155	3.39	No	No	0	8	5
93	R:R:L140	R:R:V102	4.47	Yes	No	0	7	6
94	R:R:F139	R:R:Y103	9.28	Yes	Yes	2	8	7
95	R:R:E108	R:R:K106	8.1	No	Yes	0	5	6
96	R:R:E113	R:R:K106	12.15	No	Yes	3	5	6
97	R:R:E154	R:R:K106	8.1	No	Yes	3	5	6
98	R:R:C107	R:R:V112	3.42	No	Yes	6	9	8
99	R:R:E113	R:R:E154	8.88	No	No	3	5	5
100	R:R:L114	R:R:P148	4.93	No	No	0	7	7
101	R:R:F147	R:R:P115	8.67	Yes	No	0	8	9
102	R:R:N153	R:R:S116	4.47	No	No	0	7	9
103	R:R:Q117	R:R:Q121	7.68	Yes	No	2	6	5
104	R:R:C142	R:R:Q117	4.58	Yes	Yes	2	9	6
105	R:R:E149	R:R:Q117	3.82	No	Yes	0	3	6
106	R:R:L119	R:R:T122	4.42	No	No	0	6	4
107	R:R:L119	R:R:N153	6.87	No	No	0	6	7
108	R:R:C120	R:R:R124	4.18	No	Yes	2	9	6
109	R:R:C120	R:R:C142	7.28	No	Yes	2	9	9
110	R:R:C120	R:R:F147	13.97	No	Yes	0	9	8
111	R:R:C142	R:R:Q121	4.58	Yes	No	2	9	5
112	R:R:R124	R:R:T123	9.06	Yes	No	0	6	8
113	R:R:R124	R:R:W136	28.99	Yes	Yes	2	6	9
114	R:R:C142	R:R:R124	6.96	Yes	Yes	2	9	6
115	R:R:P126	R:R:V125	3.53	No	No	0	7	3
116	R:R:A128	R:R:R132	4.15	No	No	0	5	4
117	R:R:I129	W:W:?3	2.87	No	Yes	0	6	0
118	R:R:V130	R:R:W136	18.39	No	Yes	2	7	9
119	R:R:V130	W:W:?3	4.49	No	Yes	2	7	0
120	R:R:E133	W:W:?3	18.62	No	Yes	0	4	0
121	R:R:R134	W:W:?3	10.98	No	Yes	0	5	0
122	R:R:P137	R:R:W136	5.4	Yes	Yes	2	9	9
123	R:R:L140	R:R:W136	4.56	Yes	Yes	2	7	9
124	R:R:F139	R:R:P137	7.22	Yes	Yes	2	8	9
125	R:R:L140	R:R:P137	14.78	Yes	Yes	2	7	9
126	R:R:P137	W:W:?3	4.95	Yes	Yes	2	9	0
127	R:R:D138	R:R:K141	6.91	No	No	0	4	4
128	R:R:F139	R:R:L140	7.31	Yes	Yes	2	8	7
129	R:R:F139	R:R:Y146	3.09	Yes	Yes	2	8	4
130	R:R:D145	R:R:T143	8.67	No	No	2	5	5
131	R:R:T143	R:R:Y146	6.24	No	Yes	2	5	4
132	R:R:E149	R:R:T144	5.64	No	No	0	3	4
133	R:R:D145	R:R:Y146	10.34	No	Yes	2	5	4
134	R:R:F147	R:R:Y146	3.09	Yes	Yes	0	8	4
135	R:R:C151	R:R:P148	3.77	Yes	No	0	8	7
136	R:R:N153	R:R:Q156	11.88	No	No	0	7	5
137	R:R:I158	R:R:V155	3.07	No	No	0	5	5
138	R:R:N157	R:R:T473	7.31	No	No	0	4	4
139	R:R:I158	R:R:I469	4.42	No	Yes	3	5	4
140	R:R:Q165	R:R:S162	2.89	No	No	0	3	6
141	R:R:C166	R:R:S162	3.44	No	No	5	9	6
142	R:R:C186	R:R:S162	3.44	Yes	No	5	9	6
143	R:R:I469	R:R:Q165	4.12	Yes	No	0	4	3
144	R:R:C166	R:R:R172	4.18	No	No	0	9	4
145	R:R:C166	R:R:C186	7.28	No	Yes	5	9	9
146	R:R:E167	R:R:E464	7.61	No	Yes	0	6	4
147	R:R:A468	R:R:E167	6.03	No	No	0	6	6
148	R:R:P169	R:R:Q189	6.32	No	No	0	8	7
149	R:R:P169	R:R:P193	3.9	No	No	0	8	8
150	R:R:P169	R:R:Y460	8.34	No	No	0	8	5
151	R:R:C186	R:R:L170	3.17	Yes	No	0	9	9
152	R:R:I188	R:R:L170	2.85	No	No	0	6	9
153	R:R:D174	R:R:R172	4.76	No	No	0	6	4
154	R:R:S178	R:R:T173	4.8	Yes	Yes	4	8	8
155	R:R:D271	R:R:T173	13.01	Yes	Yes	4	8	8
156	R:R:T173	R:R:T273	3.14	Yes	Yes	4	8	8
157	R:R:N175	R:R:P176	4.89	Yes	No	0	6	3
158	R:R:K177	R:R:N175	9.79	Yes	Yes	4	4	6
159	R:R:N175	R:R:S178	5.96	Yes	Yes	4	6	8
160	R:R:D271	R:R:N175	5.39	Yes	Yes	4	8	6
161	R:R:P176	R:R:W179	6.76	No	No	0	3	5
162	R:R:K177	R:R:R269	4.95	Yes	Yes	4	4	7
163	R:R:K177	R:R:T280	4.5	Yes	No	4	4	7
164	R:R:K177	R:R:S281	4.59	Yes	No	0	4	8
165	R:R:R269	R:R:S178	7.91	Yes	Yes	4	7	8
166	R:R:D271	R:R:S178	8.83	Yes	Yes	4	8	8
167	R:R:S178	R:R:T273	7.99	Yes	Yes	4	8	8
168	R:R:G185	R:R:W179	5.63	No	No	0	8	5
169	R:R:E181	R:R:Y180	13.47	No	No	10	4	8
170	R:R:F457	R:R:Y180	3.09	No	No	0	7	8
171	R:R:R458	R:R:Y180	3.09	No	No	10	5	8
172	R:R:E181	R:R:R458	9.3	No	No	10	4	5
173	R:R:C186	R:R:V183	3.42	Yes	No	5	9	7
174	R:R:I188	R:R:M274	4.37	No	No	0	6	5
175	R:R:C190	R:R:V267	3.42	No	No	0	9	8
176	R:R:C190	R:R:C268	7.28	No	No	0	9	9
177	R:R:N197	R:R:Q191	7.92	No	No	0	3	4
178	R:R:H200	R:R:Q191	17.31	Yes	No	1	8	4
179	R:R:Q191	R:R:S358	4.33	No	No	1	4	8
180	R:R:N192	R:R:P193	6.52	Yes	No	0	7	8
181	R:R:L194	R:R:N192	5.49	Yes	Yes	1	6	7
182	R:R:F195	R:R:N192	9.67	Yes	Yes	1	6	7
183	R:R:D357	R:R:N192	5.39	Yes	Yes	1	8	7
184	R:R:N192	R:R:V359	4.43	Yes	Yes	1	7	7
185	R:R:F457	R:R:P193	5.78	No	No	0	7	8
186	R:R:F195	R:R:L194	6.09	Yes	Yes	1	6	6
187	R:R:I482	R:R:L194	2.85	No	Yes	0	4	6
188	R:R:L194	R:R:P486	3.28	Yes	Yes	1	6	9
189	R:R:E199	R:R:F195	7	Yes	Yes	1	8	6
190	R:R:F195	R:R:V359	5.24	Yes	Yes	1	6	7
191	R:R:F195	R:R:R485	5.34	Yes	No	1	6	7
192	R:R:F195	R:R:P486	5.78	Yes	Yes	1	6	9
193	R:R:F195	R:R:L488	7.31	Yes	No	1	6	6
194	R:R:K198	R:R:T196	3	No	No	0	3	8
195	R:R:E199	R:R:T196	8.47	Yes	No	0	8	8
196	R:R:E199	R:R:R485	5.82	Yes	No	1	8	7
197	R:R:E199	R:R:L488	5.3	Yes	No	1	8	6
198	R:R:H200	R:R:H204	4.78	Yes	No	1	8	8
199	R:R:H200	R:R:S358	6.97	Yes	No	1	8	8
200	R:R:H200	R:R:V359	6.92	Yes	Yes	1	8	7
201	R:R:E202	R:R:K492	5.4	No	No	0	7	8
202	R:R:I207	R:R:M203	2.92	No	No	0	7	8
203	R:R:M203	R:R:V359	3.04	No	Yes	0	8	7
204	R:R:K492	R:R:M203	4.32	No	No	0	8	8
205	R:R:H204	R:R:Q257	4.95	No	Yes	1	8	9
206	R:R:H204	R:R:R263	28.21	No	No	1	8	8
207	R:R:F210	R:R:Y206	10.32	No	No	0	5	7
208	R:R:K492	R:R:Y206	20.3	No	No	0	8	7
209	R:R:L495	R:R:Y206	3.52	Yes	No	0	8	7
210	R:R:I207	R:R:W254	4.7	No	Yes	7	7	7
211	R:R:I207	R:R:L495	2.85	No	Yes	7	7	8
212	R:R:F210	R:R:F496	6.43	No	No	0	5	6
213	R:R:F210	R:R:F499	7.5	No	Yes	0	5	9
214	R:R:S211	R:R:S251	3.26	No	No	0	7	8
215	R:R:L255	R:R:S211	7.51	No	No	0	7	7
216	R:R:F499	R:R:S211	6.61	Yes	No	0	9	7
217	R:R:I503	R:R:V213	4.61	No	No	0	8	5
218	R:R:S251	R:R:T214	4.8	No	No	0	8	8
219	R:R:F499	R:R:T214	7.78	Yes	No	0	9	8
220	R:R:I503	R:R:T214	4.56	No	No	0	8	8
221	R:R:F248	R:R:I215	8.79	Yes	Yes	11	6	5
222	R:R:I215	R:R:S251	4.64	Yes	No	0	5	8
223	R:R:I215	R:R:I252	2.94	Yes	No	11	5	6
224	R:R:I215	R:R:L255	4.28	Yes	No	0	5	7
225	R:R:C217	R:R:S506	5.16	No	Yes	0	6	9
226	R:R:N244	R:R:T218	7.31	No	No	0	9	9
227	R:R:F248	R:R:T218	7.78	Yes	No	0	6	9
228	R:R:F219	R:R:F248	5.36	No	Yes	0	6	6
229	R:R:F220	R:R:T224	3.89	No	Yes	12	8	9
230	R:R:F220	R:R:W510	5.01	No	No	0	8	8
231	R:R:F220	R:R:W518	4.01	No	Yes	12	8	9
232	R:R:N244	R:R:T221	16.08	No	No	0	9	9
233	R:R:T221	R:R:V509	11.11	No	No	0	9	8
234	R:R:F241	R:R:L222	7.31	Yes	No	0	9	7
235	R:R:F248	R:R:L222	4.87	Yes	No	0	6	7
236	R:R:T224	R:R:V509	4.76	Yes	No	0	9	8
237	R:R:T224	R:R:T514	7.85	Yes	No	0	9	9
238	R:R:T224	R:R:W518	3.64	Yes	Yes	12	9	9
239	R:R:F225	R:R:S232	6.61	Yes	No	0	9	8
240	R:R:F225	R:R:F241	9.65	Yes	Yes	0	9	9
241	R:R:F225	R:R:V509	5.24	Yes	No	0	9	8
242	R:R:V227	R:R:W518	4.9	No	Yes	0	8	9
243	R:R:D228	R:R:N231	12.12	Yes	No	0	9	8
244	R:R:D228	R:R:S232	5.89	Yes	No	0	9	8
245	R:R:D228	R:R:I517	8.4	Yes	No	0	9	7
246	R:R:N233	R:R:W229	21.47	No	No	0	8	8
247	R:R:A237	R:R:R234	4.15	No	No	0	9	7
248	R:R:V238	R:R:Y235	8.83	Yes	Yes	1	7	9
249	R:R:I239	R:R:Y235	3.63	Yes	Yes	0	8	9
250	R:R:Y235	R:R:Y242	3.97	Yes	Yes	1	9	8
251	R:R:T330	R:R:Y235	11.24	No	Yes	0	7	9
252	R:R:I239	R:R:P236	3.39	Yes	No	0	8	9
253	R:R:A311	R:R:P236	3.74	No	No	0	8	9
254	R:R:P236	R:R:W312	5.4	No	Yes	0	9	7
255	R:R:F241	R:R:V238	3.93	Yes	Yes	1	9	7
256	R:R:V238	R:R:Y242	10.09	Yes	Yes	1	7	8
257	R:R:I239	R:R:W304	5.87	Yes	Yes	0	8	9
258	R:R:I239	R:R:L308	5.71	Yes	No	0	8	8
259	R:R:F241	R:R:Y242	6.19	Yes	Yes	1	9	8
260	R:R:W304	R:R:Y242	13.5	Yes	Yes	1	9	8
261	R:R:H334	R:R:Y242	9.8	No	Yes	1	9	8
262	R:R:F305	R:R:V243	3.93	Yes	No	8	8	8
263	R:R:M505	R:R:V243	3.04	Yes	No	8	9	8
264	R:R:N244	R:R:S506	4.47	No	Yes	0	9	9
265	R:R:C246	R:R:S300	5.16	No	Yes	1	9	9
266	R:R:C246	R:R:G301	3.92	No	No	1	9	8
267	R:R:F247	R:R:G301	3.01	No	No	0	8	8
268	R:R:F247	R:R:T501	3.89	No	Yes	0	8	7
269	R:R:F247	R:R:G502	6.02	No	No	0	8	9
270	R:R:F248	R:R:I252	7.54	Yes	No	11	6	6
271	R:R:G250	R:R:S297	3.71	No	No	0	7	8
272	R:R:G253	R:R:I252	3.53	No	No	0	8	6
273	R:R:G253	R:R:I293	5.29	No	No	0	8	6
274	R:R:V294	R:R:W254	8.58	No	Yes	0	8	7
275	R:R:I362	R:R:W254	12.92	No	Yes	0	9	7
276	R:R:L495	R:R:W254	3.42	Yes	Yes	7	8	7
277	R:R:F499	R:R:W254	9.02	Yes	Yes	7	9	7
278	R:R:A256	R:R:I290	3.25	No	No	0	6	7
279	R:R:F258	R:R:Q257	12.88	No	Yes	1	8	9
280	R:R:Q257	R:R:R263	12.85	Yes	No	1	9	8
281	R:R:G361	R:R:Q257	8.22	No	Yes	0	9	9
282	R:R:F258	R:R:R263	6.41	No	No	1	8	8
283	R:R:A262	R:R:M259	4.83	No	No	0	7	5
284	R:R:C268	R:R:D264	3.11	No	No	0	9	5
285	R:R:E265	R:R:T284	8.47	No	No	13	7	8
286	R:R:E265	R:R:S286	8.62	No	No	13	7	8
287	R:R:I266	R:R:I290	10.3	No	No	0	8	7
288	R:R:D271	R:R:R269	3.57	Yes	Yes	4	8	7
289	R:R:R269	R:R:T273	3.88	Yes	Yes	4	7	8
290	R:R:R269	R:R:T280	5.17	Yes	No	4	7	7
291	R:R:E283	R:R:R269	9.3	No	Yes	0	8	7
292	R:R:D271	R:R:T273	10.12	Yes	Yes	4	8	8
293	R:R:L276	R:R:M274	7.07	No	No	0	4	5
294	R:R:E278	R:R:R275	15.12	No	Yes	0	8	7
295	R:R:E283	R:R:R275	6.98	No	Yes	0	8	7
296	R:R:R275	R:R:T284	6.47	Yes	No	0	7	8
297	R:R:C287	R:R:R275	6.96	No	Yes	0	9	7
298	R:R:D355	R:R:L276	5.43	Yes	No	0	9	4
299	R:R:E278	R:R:T280	12.7	No	No	0	8	7
300	R:R:E278	R:R:V354	2.85	No	No	0	8	8
301	R:R:P279	R:R:V288	5.3	No	No	0	8	8
302	R:R:L349	R:R:P279	4.93	No	No	0	8	8
303	R:R:S286	R:R:T284	4.8	No	No	13	8	8
304	R:R:L285	R:R:V288	4.47	No	No	0	7	8
305	R:R:C287	R:R:C363	7.28	No	No	0	9	9
306	R:R:I289	R:R:I293	2.94	No	No	0	6	6
307	R:R:I290	R:R:I362	2.94	No	No	0	7	9
308	R:R:F291	R:R:Y295	7.22	Yes	Yes	1	9	9
309	R:R:F291	R:R:I348	10.05	Yes	Yes	1	9	7
310	R:R:F291	R:R:L349	3.65	Yes	No	0	9	8
311	R:R:F291	R:R:V354	14.42	Yes	No	0	9	8
312	R:R:F291	R:R:V365	3.93	Yes	Yes	1	9	9
313	R:R:I292	R:R:T345	3.04	No	No	0	7	9
314	R:R:I292	R:R:L349	2.85	No	No	0	7	8
315	R:R:M299	R:R:Y295	15.57	Yes	Yes	0	8	9
316	R:R:L344	R:R:Y295	7.03	Yes	Yes	1	8	9
317	R:R:T345	R:R:Y295	7.49	No	Yes	0	9	9
318	R:R:I348	R:R:Y295	8.46	Yes	Yes	1	7	9
319	R:R:F364	R:R:Y295	3.09	Yes	Yes	1	9	9
320	R:R:F376	R:R:Y295	6.19	Yes	Yes	1	8	9
321	R:R:W338	R:R:Y296	8.68	Yes	No	0	9	8
322	R:R:P341	R:R:Y296	5.56	Yes	No	0	9	8
323	R:R:M298	R:R:M299	4.33	No	Yes	0	7	8
324	R:R:M298	R:R:M498	4.33	No	No	0	7	6
325	R:R:M299	R:R:P341	3.35	Yes	Yes	0	8	9
326	R:R:M299	R:R:P380	3.35	Yes	No	0	8	9
327	R:R:G301	R:R:S300	3.71	No	Yes	1	8	9
328	R:R:S300	R:R:W338	7.41	Yes	Yes	1	9	9
329	R:R:P341	R:R:S300	3.56	Yes	Yes	1	9	9
330	R:R:I303	R:R:T337	3.04	Yes	No	1	7	9
331	R:R:I303	R:R:I340	2.94	Yes	Yes	1	7	5
332	R:R:I303	R:R:P341	3.39	Yes	Yes	1	7	9
333	R:R:M307	R:R:W304	4.65	No	Yes	0	7	9
334	R:R:H334	R:R:W304	6.35	No	Yes	1	9	9
335	R:R:T337	R:R:W304	29.11	No	Yes	1	9	9
336	R:R:W304	R:R:W338	7.5	Yes	Yes	1	9	9
337	R:R:F305	R:R:F428	4.29	Yes	Yes	0	8	8
338	R:R:F305	R:R:T501	3.89	Yes	Yes	8	8	7
339	R:R:F305	R:R:M505	7.46	Yes	Yes	8	8	9
340	R:R:M307	R:R:V306	3.04	No	No	0	7	9
341	R:R:V306	R:R:V384	4.81	No	No	0	9	6
342	R:R:F333	R:R:M307	7.46	No	No	0	9	7
343	R:R:L308	R:R:W312	17.08	No	Yes	0	8	7
344	R:R:G388	R:R:T309	5.46	No	No	0	8	8
345	R:R:F391	R:R:T309	3.89	Yes	No	0	8	8
346	R:R:T314	R:R:Y310	8.74	No	Yes	0	6	8
347	R:R:K329	R:R:Y310	5.97	No	Yes	0	8	8
348	R:R:F333	R:R:Y310	5.16	No	Yes	0	9	8
349	R:R:F391	R:R:Y310	11.35	Yes	Yes	0	8	8
350	R:R:L425	R:R:W312	5.69	No	Yes	0	8	7
351	R:R:F428	R:R:W312	5.01	Yes	Yes	0	8	7
352	R:R:W312	R:R:W508	5.62	Yes	No	0	7	9
353	R:R:H313	R:R:K317	10.48	Yes	No	0	7	5
354	R:R:F391	R:R:H313	5.66	Yes	Yes	0	8	7
355	R:R:H313	R:R:R394	11.28	Yes	No	0	7	7
356	R:R:F316	R:R:T421	3.89	No	No	0	8	8
357	R:R:S327	R:R:T330	3.2	No	No	0	6	7
358	R:R:H334	R:R:W338	9.52	No	Yes	1	9	9
359	R:R:T337	R:R:W338	3.64	No	Yes	1	9	9
360	R:R:I340	R:R:P341	3.39	Yes	Yes	1	5	9
361	R:R:I340	R:R:L344	2.85	Yes	Yes	1	5	8
362	R:R:F342	R:R:V346	7.87	No	No	0	9	8
363	R:R:F376	R:R:L344	6.09	Yes	Yes	1	8	8
364	R:R:L344	R:R:P380	3.28	Yes	No	0	8	9
365	R:R:I348	R:R:V365	9.22	Yes	Yes	1	7	9
366	R:R:F376	R:R:I348	15.07	Yes	Yes	1	8	7
367	R:R:Q353	R:R:V351	2.87	Yes	No	14	7	6
368	R:R:V351	R:R:Y372	5.05	No	No	14	6	5
369	R:R:D355	R:R:Q353	3.92	Yes	Yes	0	9	7
370	R:R:N369	R:R:Q353	11.88	No	Yes	0	8	7
371	R:R:Q353	R:R:Y372	14.65	Yes	No	14	7	5
372	R:R:D355	R:R:Y367	5.75	Yes	Yes	0	9	5
373	R:R:D355	R:R:K368	4.15	Yes	No	0	9	4
374	R:R:C363	R:R:G356	3.92	No	No	0	9	8
375	R:R:D357	R:R:V359	8.76	Yes	Yes	1	8	7
376	R:R:D357	R:R:S360	8.83	Yes	No	0	8	8
377	R:R:D357	R:R:Y367	4.6	Yes	Yes	1	8	5
378	R:R:I362	R:R:S360	7.74	No	No	0	9	8
379	R:R:F364	R:R:V365	7.87	Yes	Yes	1	9	9
380	R:R:F364	R:R:Y367	10.32	Yes	Yes	1	9	5
381	R:R:F364	R:R:R373	3.21	Yes	No	1	9	9
382	R:R:F376	R:R:V365	3.93	Yes	Yes	1	8	9
383	R:R:R373	R:R:Y367	8.23	No	Yes	1	9	5
384	R:R:K368	R:R:N369	13.99	No	No	0	4	8
385	R:R:H371	R:R:Y370	19.6	No	Yes	15	3	4
386	R:R:F447	R:R:Y370	9.28	No	Yes	15	6	4
387	R:R:Q450	R:R:Y370	20.29	No	Yes	0	7	4
388	R:R:F447	R:R:H371	6.79	No	No	15	6	3
389	R:R:H443	R:R:R373	13.54	Yes	No	1	9	9
390	R:R:A374	R:R:L378	3.15	No	Yes	0	6	7
391	R:R:L378	R:R:V377	2.98	Yes	No	0	7	8
392	R:R:F440	R:R:L378	12.18	No	Yes	0	6	7
393	R:R:H443	R:R:L378	7.71	Yes	Yes	0	9	7
394	R:R:I381	R:R:V436	3.07	No	No	0	7	8
395	R:R:F440	R:R:G382	3.01	No	No	0	6	4
396	R:R:L385	R:R:V436	10.43	No	No	0	6	8
397	R:R:G387	R:R:I386	3.53	No	No	0	6	4
398	R:R:F391	R:R:Y390	11.35	Yes	No	0	8	5
399	R:R:R394	R:R:Y390	5.14	No	No	0	7	5
400	R:R:F428	R:R:L392	7.31	Yes	No	0	8	7
401	R:R:L425	R:R:V396	2.98	No	No	0	8	8
402	R:R:F400	R:R:M397	3.73	No	No	0	7	5
403	R:R:I418	R:R:L399	4.28	No	No	0	9	9
404	R:R:L399	R:R:M422	4.24	No	No	0	9	8
405	R:R:L423	R:R:N419	6.87	No	No	0	7	6
406	R:R:R424	R:R:W508	6	No	No	0	9	9
407	R:R:F428	R:R:G429	3.01	Yes	No	0	8	7
408	R:R:A432	R:R:F428	4.16	No	Yes	0	7	8
409	R:R:F435	R:R:L431	6.09	No	No	0	7	6
410	R:R:L431	R:R:S504	6.01	No	No	0	6	7
411	R:R:F435	R:R:G500	4.52	No	No	0	7	6
412	R:R:F435	R:R:T501	9.08	No	Yes	0	7	7
413	R:R:H443	R:R:T439	5.48	Yes	No	1	9	8
414	R:R:N494	R:R:T439	5.85	No	No	1	8	8
415	R:R:C442	R:R:V490	3.42	Yes	Yes	0	7	7
416	R:R:C442	R:R:I493	3.27	Yes	No	0	7	6
417	R:R:C442	R:R:N494	6.3	Yes	No	0	7	8
418	R:R:H443	R:R:N494	10.2	Yes	No	1	9	8
419	R:R:F444	R:R:F448	4.29	No	No	0	5	3
420	R:R:N449	R:R:Y445	5.81	No	No	1	7	8
421	R:R:W453	R:R:Y445	5.79	Yes	No	1	9	8
422	R:R:V490	R:R:Y445	5.05	Yes	No	0	7	8
423	R:R:D446	R:R:W453	7.82	No	Yes	0	7	9
424	R:R:D446	R:R:E491	6.5	No	No	0	7	6
425	R:R:N449	R:R:W453	5.65	No	Yes	1	7	9
426	R:R:E454	R:R:Q450	3.82	No	No	0	5	7
427	R:R:E452	R:R:R455	11.63	No	No	0	2	4
428	R:R:E452	R:R:K483	8.1	No	No	1	2	3
429	R:R:E452	R:R:N484	11.83	No	Yes	1	2	4
430	R:R:N484	R:R:W453	5.65	Yes	Yes	1	4	9
431	R:R:P486	R:R:W453	24.32	Yes	Yes	1	9	9
432	R:R:I482	R:R:S456	4.64	No	No	0	4	8
433	R:R:K483	R:R:S456	6.12	No	No	1	3	8
434	R:R:N484	R:R:S456	7.45	Yes	No	1	4	8
435	R:R:F457	R:R:V461	7.87	No	No	0	7	6
436	R:R:E464	R:R:Y460	8.98	Yes	No	0	4	5
437	R:R:I482	R:R:Y460	4.84	No	No	0	4	5
438	R:R:C463	R:R:C480	7.28	No	No	0	9	9
439	R:R:E464	R:R:V467	5.7	Yes	No	0	4	6
440	R:R:C480	R:R:E464	6.08	No	Yes	0	9	4
441	R:R:N466	R:R:P478	3.26	No	No	0	7	4
442	R:R:A470	R:R:I477	3.25	No	No	0	4	4
443	R:R:K475	R:R:T473	3	No	No	0	4	4
444	R:R:K475	R:R:P476	5.02	No	No	0	4	4
445	R:R:K483	R:R:N484	13.99	No	Yes	1	3	4
446	R:R:P486	R:R:R485	2.88	Yes	No	1	9	7
447	R:R:S487	R:R:V490	4.85	No	Yes	0	8	7
448	R:R:E491	R:R:V490	2.85	No	Yes	0	6	7
449	R:R:F499	R:R:L495	4.87	Yes	Yes	7	9	8
450	R:R:M505	R:R:T501	3.01	Yes	Yes	8	9	7
451	R:R:I503	R:R:S506	3.1	No	Yes	0	8	9
452	R:R:M505	R:R:S504	6.13	Yes	No	0	9	7
453	R:R:T511	R:R:T514	4.71	No	No	0	9	9
454	R:R:I469	R:R:N157	2.83	Yes	No	0	4	4
455	R:R:A208	R:R:F258	2.77	No	No	0	6	8
456	R:R:L240	R:R:L308	2.77	No	No	0	8	8
457	R:R:A347	R:R:F376	2.77	No	Yes	0	6	8
458	R:R:A374	R:R:F447	2.77	No	No	0	6	6
459	R:R:H313	R:R:T398	2.74	Yes	No	0	7	7
460	R:R:E471	R:R:I477	2.73	No	No	0	2	4
461	R:R:D93	R:R:N161	2.69	No	No	0	5	8
462	R:R:A131	R:R:W136	2.59	No	Yes	0	5	9
463	R:R:A223	R:R:W518	2.59	No	Yes	0	6	9
464	R:R:F316	R:R:T398	2.59	No	No	0	8	7
465	R:R:F216	R:R:I215	2.51	No	Yes	0	3	5
466	R:R:L335	R:R:Y332	2.34	No	No	0	6	7
467	R:R:F440	R:R:F444	2.14	No	No	0	6	5
468	R:R:G109	R:R:G110	2.11	No	No	0	5	5
469	R:R:G387	R:R:G388	2.11	No	No	0	6	8
470	R:R:G388	R:R:G389	2.11	No	No	0	8	6
471	R:R:F342	R:R:Y296	2.06	No	No	0	9	8
472	R:R:C43	R:R:G110	1.96	No	No	0	9	5
473	R:R:A163	R:R:G164	1.95	No	No	0	7	6
474	R:R:A249	R:R:G250	1.95	No	No	0	5	7
475	R:R:C37	R:R:P152	1.88	No	No	9	9	5
476	R:R:C127	R:R:P126	1.88	No	No	0	9	7
477	R:R:C151	R:R:P152	1.88	Yes	No	9	8	5
478	R:R:A88	R:R:P89	1.87	No	No	0	7	9
479	R:R:A94	R:R:P126	1.87	No	No	0	8	7
480	R:R:A352	R:R:P279	1.87	No	No	0	7	8
481	R:R:A379	R:R:P380	1.87	No	No	0	6	9
482	R:R:G356	R:R:V267	1.84	No	No	0	8	8
483	R:R:G361	R:R:V267	1.84	No	No	0	9	8
484	R:R:G366	R:R:V365	1.84	No	Yes	0	9	9
485	R:R:G187	R:R:T173	1.82	No	Yes	4	8	8
486	R:R:G187	R:R:T273	1.82	No	Yes	4	8	8
487	R:R:G395	R:R:T398	1.82	No	No	0	8	7
488	R:R:A88	R:R:C91	1.81	No	No	0	7	9
489	R:R:P478	R:R:V467	1.77	No	No	0	4	6
490	R:R:G250	R:R:I293	1.76	No	No	0	7	6
491	R:R:C151	R:R:S116	1.72	Yes	No	0	8	9
492	R:R:G382	R:R:L385	1.71	No	No	0	4	6
493	R:R:G434	R:R:L437	1.71	No	No	0	5	4
494	R:R:A521	R:R:V227	1.7	No	No	0	7	8
495	R:R:I477	R:R:P478	1.69	No	No	0	4	4
496	R:R:D355	R:R:G277	1.68	Yes	No	0	9	6
497	R:R:A497	R:R:T439	1.68	No	No	0	8	8
498	R:R:A513	R:R:T511	1.68	No	No	0	8	9
499	R:R:L65	R:R:P115	1.64	No	No	0	8	9
500	R:R:G118	R:R:Q117	1.64	No	Yes	2	6	6
501	R:R:G118	R:R:Q121	1.64	No	No	2	6	5
502	R:R:E283	R:R:G270	1.64	No	No	0	8	5
503	R:R:C442	R:R:I438	1.64	Yes	No	0	7	5
504	R:R:S281	R:R:S282	1.63	No	No	0	8	7
505	R:R:V302	R:R:V384	1.6	No	No	0	6	6
506	R:R:S506	R:R:T507	1.6	Yes	No	0	9	8
507	R:R:T273	R:R:V171	1.59	Yes	No	0	8	7
508	R:R:A245	R:R:L222	1.58	No	No	0	6	7
509	R:R:E44	R:R:P45	1.57	No	No	0	6	4
510	R:R:I209	R:R:V213	1.54	No	No	0	5	5
511	R:R:I393	R:R:V396	1.54	No	No	0	5	8
512	R:R:F444	R:R:G441	1.51	No	No	0	5	5
513	R:R:G84	R:R:R86	1.5	No	Yes	0	6	6
514	R:R:K141	R:R:T143	1.5	No	No	0	4	5
515	R:R:L255	R:R:S212	1.5	No	No	0	7	6
516	R:R:L489	R:R:S487	1.5	No	No	0	5	8
517	R:R:N233	R:R:V238	1.48	No	Yes	0	8	7
518	R:R:I303	R:R:I336	1.47	Yes	No	1	7	5
519	R:R:I336	R:R:I340	1.47	No	Yes	1	5	5
520	R:R:I516	R:R:I517	1.47	No	No	0	4	7
521	R:R:I393	R:R:M397	1.46	No	No	0	5	5
522	R:R:I386	R:R:L383	1.43	No	No	0	4	4
523	R:R:I438	R:R:L437	1.43	No	No	0	5	4
524	R:R:M422	R:R:N419	1.4	No	No	0	8	6
525	R:R:A237	R:R:F225	1.39	No	Yes	0	9	9
526	R:R:A451	R:R:Y370	1.33	No	Yes	0	3	4
527	R:R:E459	R:R:L462	1.33	No	No	0	3	4
528	R:R:F316	R:R:S315	1.32	No	No	0	8	8
529	R:R:F342	R:R:V343	1.31	No	No	0	9	6
530	R:R:A521	R:R:W522	1.3	No	No	0	7	4
531	R:R:F433	R:R:L385	1.22	No	No	0	5	6
532	R:R:N87	R:R:R86	1.21	No	Yes	0	5	6
533	R:R:D228	R:R:R520	1.19	Yes	No	0	9	7
534	R:R:L226	R:R:W229	1.14	No	No	0	5	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L56	6.846	5	3	7
2	R:R:P57	5.1725	4	3	7
3	R:R:Y58	11.41	4	3	9
4	R:R:S62	4.8775	4	6	8
5	R:R:D68	7.762	5	2	6
6	R:R:S69	3.994	5	2	7
7	R:R:W82	10.1683	6	2	7
8	R:R:R86	3.165	4	0	6
9	R:R:W92	11.7675	4	0	9
10	R:R:I95	5.286	5	2	8
11	R:R:Y103	8.225	6	2	7
12	R:R:K106	12.1625	4	3	6
13	R:R:V112	3.6125	4	6	8
14	R:R:Q117	4.43	4	2	6
15	R:R:R124	12.2975	4	2	6
16	R:R:W136	10.575	6	2	9
17	R:R:P137	8.0875	4	2	9
18	R:R:F139	8.02833	6	2	8
19	R:R:L140	6.908	5	2	7
20	R:R:C142	5.85	4	2	9
21	R:R:Y146	7.022	5	2	4
22	R:R:F147	7.65	4	0	8
23	R:R:C151	3.6625	4	9	8
24	R:R:F160	10.15	4	0	8
25	R:R:T173	5.6925	4	4	8
26	R:R:N175	6.5075	4	4	6
27	R:R:K177	5.9575	4	4	4
28	R:R:S178	7.098	5	4	8
29	R:R:C186	4.3275	4	5	9
30	R:R:N192	6.3	5	1	7
31	R:R:L194	4.4275	4	1	6
32	R:R:F195	6.63286	7	1	6
33	R:R:E199	6.6475	4	1	8
34	R:R:H200	8.995	4	1	8
35	R:R:I215	4.632	5	11	5
36	R:R:T224	5.035	4	12	9
37	R:R:F225	5.7225	4	0	9
38	R:R:D228	6.9	4	0	9
39	R:R:Y235	6.9175	4	1	9
40	R:R:V238	6.0825	4	1	7
41	R:R:I239	4.65	4	0	8
42	R:R:F241	6.77	4	1	9
43	R:R:Y242	8.71	5	1	8
44	R:R:F248	6.868	5	11	6
45	R:R:W254	7.728	5	7	7
46	R:R:Q257	9.725	4	1	9
47	R:R:R269	5.79667	6	4	7
48	R:R:D271	8.184	5	4	8
49	R:R:T273	4.75667	6	4	8
50	R:R:R275	8.8825	4	0	7
51	R:R:F291	7.854	5	1	9
52	R:R:Y295	7.86428	7	1	9
53	R:R:M299	6.65	4	0	8
54	R:R:S300	4.96	4	1	9
55	R:R:I303	2.71	4	1	7
56	R:R:W304	11.1633	6	1	9
57	R:R:F305	4.8925	4	8	8
58	R:R:Y310	7.805	4	0	8
59	R:R:W312	7.76	5	0	7
60	R:R:H313	7.54	4	0	7
61	R:R:W338	7.35	5	1	9
62	R:R:I340	2.6625	4	1	5
63	R:R:P341	3.85	5	1	9
64	R:R:L344	4.8125	4	1	8
65	R:R:I348	10.7	4	1	7
66	R:R:Q353	8.33	4	14	7
67	R:R:D355	4.186	5	0	9
68	R:R:D357	6.895	4	1	8
69	R:R:V359	5.678	5	1	7
70	R:R:F364	6.1225	4	1	9
71	R:R:V365	5.358	5	1	9
72	R:R:Y367	7.225	4	1	5
73	R:R:Y370	12.625	4	15	4
74	R:R:F376	6.81	5	1	8
75	R:R:L378	6.505	4	0	7
76	R:R:F391	8.0625	4	0	8
77	R:R:F428	4.756	5	0	8
78	R:R:C442	3.6575	4	0	7
79	R:R:H443	9.2325	4	1	9
80	R:R:W453	9.846	5	1	9
81	R:R:E464	7.0925	4	0	4
82	R:R:I469	4.1125	4	3	4
83	R:R:N484	9.73	4	1	4
84	R:R:P486	9.065	4	1	9
85	R:R:V490	4.0425	4	0	7
86	R:R:L495	3.665	4	7	8
87	R:R:F499	7.156	5	7	9
88	R:R:T501	4.9675	4	8	7
89	R:R:M505	4.91	4	8	9
90	R:R:S506	3.5825	4	0	9
91	R:R:W518	3.785	4	12	9
92	W:W:?3	9.99125	8	2	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C100	R:R:F160	23.6743	4.19	No	Yes	0	9	8
2	R:R:C100	R:R:C51	24.2287	7.28	No	No	0	9	9
3	R:R:C51	R:R:L56	24.7509	4.76	No	Yes	3	9	7
4	R:R:L46	R:R:L56	17.3208	5.54	No	Yes	0	7	7
5	R:R:L46	R:R:T61	14.8739	7.37	No	No	0	7	9
6	R:R:Q72	R:R:T61	13.6994	5.67	No	No	0	8	9
7	R:R:L56	R:R:P57	41.6428	3.28	Yes	Yes	3	7	7
8	R:R:I469	R:R:P57	45.2037	5.08	Yes	Yes	3	4	7
9	R:R:I469	R:R:Q165	82.907	4.12	Yes	No	0	4	3
10	R:R:Q165	R:R:S162	83.3719	2.89	No	No	0	3	6
11	R:R:C186	R:R:S162	83.5004	3.44	Yes	No	5	9	6
12	R:R:F160	R:R:R96	16.4178	20.31	Yes	No	0	8	8
13	R:R:R96	R:R:W92	14.7264	23.99	No	Yes	0	8	9
14	R:R:F139	R:R:Y146	17.9165	3.09	Yes	Yes	2	8	4
15	R:R:F147	R:R:Y146	21.0317	3.09	Yes	Yes	0	8	4
16	R:R:C120	R:R:F147	11.0408	13.97	No	Yes	0	9	8
17	R:R:A101	R:R:V155	34.8795	3.39	No	No	0	8	5
18	R:R:I158	R:R:V155	35.4514	3.07	No	No	0	5	5
19	R:R:A101	R:R:P115	34.3213	3.74	No	No	0	8	9
20	R:R:C186	R:R:L170	87.9369	3.17	Yes	No	0	9	9
21	R:R:I188	R:R:L170	88.385	2.85	No	No	0	6	9
22	R:R:I188	R:R:M274	88.8315	4.37	No	No	0	6	5
23	R:R:L276	R:R:M274	89.2766	7.07	No	No	0	4	5
24	R:R:D355	R:R:L276	89.7201	5.43	Yes	No	0	9	4
25	R:R:D355	R:R:Y367	93.213	5.75	Yes	Yes	0	9	5
26	R:R:D357	R:R:Y367	56.7782	4.6	Yes	Yes	1	8	5
27	R:R:D357	R:R:N192	31.4661	5.39	Yes	Yes	1	8	7
28	R:R:N192	R:R:P193	15.3259	6.52	Yes	No	0	7	8
29	R:R:P169	R:R:P193	10.6737	3.9	No	No	0	8	8
30	R:R:E464	R:R:Y460	19.0589	8.98	Yes	No	0	4	5
31	R:R:L194	R:R:N192	17.2543	5.49	Yes	Yes	1	6	7
32	R:R:I482	R:R:L194	16.4522	2.85	No	Yes	0	4	6
33	R:R:I482	R:R:Y460	11.7901	4.84	No	No	0	4	5
34	R:R:F364	R:R:Y367	95.7983	10.32	Yes	Yes	1	9	5
35	R:R:F364	R:R:Y295	100	3.09	Yes	Yes	1	9	9
36	R:R:F291	R:R:Y295	22.7567	7.22	Yes	Yes	1	9	9
37	R:R:F291	R:R:V354	25.6654	14.42	Yes	No	0	9	8
38	R:R:E278	R:R:V354	24.7823	2.85	No	No	0	8	8
39	R:R:E278	R:R:T280	15.5591	12.7	No	No	0	8	7
40	R:R:D357	R:R:V359	13.9678	8.76	Yes	Yes	1	8	7
41	R:R:F195	R:R:V359	12.3453	5.24	Yes	Yes	1	6	7
42	R:R:M203	R:R:V359	18.3332	3.04	No	Yes	0	8	7
43	R:R:I207	R:R:M203	16.2817	2.92	No	No	0	7	8
44	R:R:D357	R:R:S360	18.165	8.83	Yes	No	0	8	8
45	R:R:I362	R:R:S360	17.7827	7.74	No	No	0	9	8
46	R:R:I362	R:R:W254	17.1985	12.92	No	Yes	0	9	7
47	R:R:F499	R:R:W254	25.2885	9.02	Yes	Yes	7	9	7
48	R:R:F499	R:R:S211	18.48	6.61	Yes	No	0	9	7
49	R:R:F499	R:R:T214	18.0289	7.78	Yes	No	0	9	8
50	R:R:I215	R:R:S251	17.889	4.64	Yes	No	0	5	8
51	R:R:F248	R:R:I215	18.1604	8.79	Yes	Yes	11	6	5
52	R:R:T224	R:R:V509	17.7972	4.76	Yes	No	0	9	8
53	R:R:M299	R:R:Y295	84.5755	15.57	Yes	Yes	0	8	9
54	R:R:M299	R:R:P341	84.9127	3.35	Yes	Yes	0	8	9
55	R:R:P341	R:R:Y296	29.9712	5.56	Yes	No	0	9	8
56	R:R:W338	R:R:Y296	29.4696	8.68	Yes	No	0	9	8
57	R:R:W304	R:R:W338	42.9572	7.5	Yes	Yes	1	9	9
58	R:R:W304	R:R:Y242	36.2245	13.5	Yes	Yes	1	9	8
59	R:R:F241	R:R:Y242	42.3944	6.19	Yes	Yes	1	9	8
60	R:R:F225	R:R:F241	34.9804	9.65	Yes	Yes	0	9	9
61	R:R:F225	R:R:V509	18.6727	5.24	Yes	No	0	9	8
62	R:R:P341	R:R:S300	33.9772	3.56	Yes	Yes	1	9	9
63	R:R:S300	R:R:W338	30.3657	7.41	Yes	Yes	1	9	9
64	R:R:I303	R:R:P341	21.3429	3.39	Yes	Yes	1	7	9
65	R:R:I303	R:R:T337	42.5359	3.04	Yes	No	1	7	9
66	R:R:T337	R:R:W304	42.0985	29.11	No	Yes	1	9	9
67	R:R:L344	R:R:Y295	22.1947	7.03	Yes	Yes	1	8	9
68	R:R:I340	R:R:L344	22.1305	2.85	Yes	Yes	1	5	8
69	R:R:I303	R:R:I340	21.57	2.94	Yes	Yes	1	7	5
70	R:R:H334	R:R:W338	16.3933	9.52	No	Yes	1	9	9
71	R:R:H334	R:R:Y242	15.907	9.8	No	Yes	1	9	8
72	R:R:F248	R:R:L222	19.8755	4.87	Yes	No	0	6	7
73	R:R:F241	R:R:L222	20.5239	7.31	Yes	No	0	9	7
74	R:R:F225	R:R:S232	13.1825	6.61	Yes	No	0	9	8
75	R:R:D228	R:R:S232	10.9865	5.89	Yes	No	0	9	8
76	R:R:I239	R:R:W304	29.5483	5.87	Yes	Yes	0	8	9
77	R:R:I239	R:R:P236	15.439	3.39	Yes	No	0	8	9
78	R:R:P236	R:R:W312	12.7383	5.4	No	Yes	0	9	7
79	R:R:I239	R:R:L308	15.439	5.71	Yes	No	0	8	8
80	R:R:L308	R:R:W312	12.7383	17.08	No	Yes	0	8	7
81	R:R:M307	R:R:W304	30.2411	4.65	No	Yes	0	7	9
82	R:R:F333	R:R:M307	25.4666	7.46	No	No	0	9	7
83	R:R:F333	R:R:Y310	24.2692	5.16	No	Yes	0	9	8
84	R:R:F391	R:R:Y310	20.6677	11.35	Yes	Yes	0	8	8
85	R:R:L425	R:R:W312	13.7629	5.69	No	Yes	0	8	7
86	R:R:H443	R:R:R373	19.8403	13.54	Yes	No	1	9	9
87	R:R:H443	R:R:L378	11.6295	7.71	Yes	Yes	0	9	7
88	R:R:L425	R:R:V396	11.0132	2.98	No	No	0	8	8
89	R:R:P486	R:R:W453	10.637	24.32	Yes	Yes	1	9	9
90	R:R:E464	R:R:V467	10.4183	5.7	Yes	No	0	4	6
91	R:R:F147	R:R:P115	33.2186	8.67	Yes	No	0	8	9
92	R:R:I158	R:R:I469	35.3551	4.42	No	Yes	3	5	4
93	R:R:F364	R:R:R373	13.3599	3.21	Yes	No	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D68	R:R:S69	4.42	2	Yes	Yes	6	7	1	2
R:R:D68	R:R:K78	4.15	2	Yes	No	6	5	1	2
R:R:D68	R:R:Y103	11.49	2	Yes	Yes	6	7	1	2
R:R:D68	R:R:F139	11.94	2	Yes	Yes	6	8	1	2
R:R:D68	W:W:?3	6.81	2	Yes	Yes	6	0	1	0
R:R:K78	R:R:S69	4.59	2	No	Yes	5	7	2	2
R:R:K78	R:R:Y103	5.97	2	No	Yes	5	7	2	2
R:R:L81	W:W:?3	8.34	0	No	Yes	4	0	1	0
R:R:I95	R:R:W82	3.52	2	Yes	Yes	8	7	2	1
R:R:L99	R:R:W82	15.94	2	No	Yes	9	7	2	1
R:R:W82	R:R:Y103	11.58	2	Yes	Yes	7	7	1	2
R:R:V130	R:R:W82	3.68	2	No	Yes	7	7	1	1
R:R:L140	R:R:W82	3.42	2	Yes	Yes	7	7	2	1
R:R:W82	W:W:?3	22.87	2	Yes	Yes	7	0	1	0
R:R:I95	R:R:L99	9.99	2	Yes	No	8	9	2	2
R:R:I95	R:R:W136	3.52	2	Yes	Yes	8	9	2	2
R:R:F139	R:R:Y103	9.28	2	Yes	Yes	8	7	2	2
R:R:I129	W:W:?3	2.87	0	No	Yes	6	0	1	0
R:R:V130	R:R:W136	18.39	2	No	Yes	7	9	1	2
R:R:V130	W:W:?3	4.49	2	No	Yes	7	0	1	0
R:R:E133	W:W:?3	18.62	0	No	Yes	4	0	1	0
R:R:R134	W:W:?3	10.98	0	No	Yes	5	0	1	0
R:R:P137	R:R:W136	5.4	2	Yes	Yes	9	9	1	2
R:R:L140	R:R:W136	4.56	2	Yes	Yes	7	9	2	2
R:R:F139	R:R:P137	7.22	2	Yes	Yes	8	9	2	1
R:R:L140	R:R:P137	14.78	2	Yes	Yes	7	9	2	1
R:R:P137	W:W:?3	4.95	2	Yes	Yes	9	0	1	0
R:R:F139	R:R:L140	7.31	2	Yes	Yes	8	7	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
100.00	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
100.00	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
100.00	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
100.00	Single	6UO8	SKF97541	6UO8-GABA_B1, GABA_B2-SKF97541-GS39783
100.00	Single	6UO9	SKF97541	6UO9-GABA_B1, GABA_B2-SKF97541
100.00	Single	6W2X	PubChem 5311042	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
100.00	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
100.00	Single	7C7Q	Baclofen	7C7Q-GABA_B1, GABA_B2-Baclofen-PubChem 7023848
100.00	Single	7C7S	CGP54626	7C7S-GABA_B1, GABA_B2-CGP54626
100.00	Single	7CUM	CGP54626	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
100.00	Single	7DD5	Ca3	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DD5	Ca	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
100.00	Single	7DGE	Quisqualate	7DGE-mGlu1; mGlu1-Quisqualate
100.00	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
100.00	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
100.00	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
100.00	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
100.00	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
100.00	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
100.00	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
100.00	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
100.00	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
100.00	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
100.00	Single	7EB2	Baclofen	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
100.00	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
100.00	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
100.00	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
100.00	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
100.00	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
100.00	Single	7FIH	hCG	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
100.00	Single	7FII	hCG	7FII-LH-hCG-6fuf
100.00	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
100.00	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143; PO4	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
100.00	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
100.00	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
100.00	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
100.00	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
100.00	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
100.00	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
100.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
100.00	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
100.00	Single	7T9N	M22 Fab	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
100.00	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
100.00	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
100.00	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
100.00	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
100.00	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
100.00	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
100.00	Single	7XW6	M22 Fab	7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
100.00	Single	7XW7	K1-70	7XW7-TSH-K1-70
100.00	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
100.00	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
100.00	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
100.00	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
100.00	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
100.00	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
100.00	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
100.00	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
100.00	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
100.00	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
100.00	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
100.00	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
100.00	Single	8JD0	Glutamate	8JD0-mGlu2; mGlu3-Glutamate-J9R
100.00	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
100.00	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
100.00	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
100.00	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
100.00	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
100.00	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
100.00	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
100.00	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
100.00	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
100.00	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
100.00	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
100.00	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
100.00	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
100.00	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
100.00	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
100.00	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
100.00	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
100.00	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
100.00	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
100.00	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
100.00	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
100.00	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
100.00	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
100.00	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
100.00	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
100.00	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
100.00	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
100.00	Consensus	class-c_off	Orthosteric Ligand	gabab_off mglu_off
100.00	Consensus	class-c_off	Orthosteric Ligand	gabab_off mglu_off
100.00	Consensus	class-c_on	Orthosteric Ligand	gabab_on mglu_on
100.00	Consensus	class-c_on	Orthosteric Ligand	gabab_on mglu_on
100.00	Consensus	fsh_on_allo	Orthosteric Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
100.00	Consensus	gabab_off	Orthosteric Ligand	7C7S-GABA_B1, GABA_B2-CGP54626 7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid 6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
100.00	Consensus	gabab_on	Orthosteric Ligand	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00	Consensus	gi_class-c	Orthosteric Ligand	gi_mglu gi_gaba
100.00	Consensus	gi_class-c	Orthosteric Ligand	gi_mglu gi_gaba
100.00	Consensus	gi_gaba	Orthosteric Ligand	7EB2-GABA_B1, GABA_B2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
100.00	Consensus	gi_mglu	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Consensus	gi_mglu	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Consensus	gphr_on	Orthosteric Ligand	lh_on tsh_on
100.00	Consensus	gs_gphr	Orthosteric Ligand	7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
100.00	Consensus	gs_protein	Orthosteric Ligand	gs_gphr
100.00	Consensus	lh_on	Orthosteric Ligand	7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
100.00	Consensus	lh_on_allo	Orthosteric Ligand	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
100.00	Consensus	mglu2_off	Orthosteric Ligand	7MTQ-mGlu2; mGlu2-LY341495
100.00	Consensus	mglu2_off	Orthosteric Ligand	7MTQ-mGlu2; mGlu2-LY341495
100.00	Consensus	mglu2_on	Orthosteric Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00	Consensus	mglu2_on	Orthosteric Ligand	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
100.00	Consensus	mglu3_off	Orthosteric Ligand	7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
100.00	Consensus	mglu3_off	Orthosteric Ligand	7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
100.00	Consensus	mglu4_on	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Consensus	mglu4_on	Orthosteric Ligand	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
100.00	Consensus	mglu5_off	Orthosteric Ligand	7FD9-mGlu5; mGlu5-LY341495
100.00	Consensus	mglu5_off	Orthosteric Ligand	7FD9-mGlu5; mGlu5-LY341495
100.00	Consensus	mglu_off	Orthosteric Ligand	mglu2_off mglu3_off mglu5_off
100.00	Consensus	mglu_off	Orthosteric Ligand	mglu2_off mglu3_off mglu5_off
100.00	Consensus	mglu_on	Orthosteric Ligand	mglu2_on mglu4_on
100.00	Consensus	mglu_on	Orthosteric Ligand	mglu2_on mglu4_on
100.00	Consensus	smo_off_allo	Other Ligand	6D32-SMO-Cyclopamine-Cyclopamine
100.00	Consensus	tsh_on	Orthosteric Ligand	7T9I-TSH-TSH-Gs/&β;1/&γ;2
100.00	Consensus	tsh_on_allo	Orthosteric Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
50.00	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
50.00	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
50.00	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
33.33	Single	7KNU	Calcitonin gene-related peptide-1	7KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
33.33	Single	7T9M	CS-17 Antibody	7T9M-TSH-CS-17 Antibody
33.33	Single	8HS2	Fab046	8HS2-GPR20-Fab046
25.00	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
25.00	Single	7FIG	hCG	7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
25.00	Single	7UTZ	TR1402	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
25.00	Single	7XW5	TSH	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
25.00	Single	7ZI0	Cholesterol	7ZI0-SMO-SAG-Cholesterol
20.00	Single	5L7D	Cholesterol	5L7D-SMO-Cholesterol
20.00	Single	7T9I	TSH	7T9I-TSH-TSH-Gs/&β;1/&γ;2
20.00	Single	8HSC	Fab046	8HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
20.00	Single	8I2G	Glycoprotein hormones alpha chain	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
16.67	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
16.67	Single	8U4Q	REGN7663-Fab	8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
14.29	Single	4XNW	MRS2500	4XNW-P2Y₁-MRS2500
14.29	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
14.29	Single	6LI0	GTPL9804	6LI0-GPR52-GTPL9804
14.29	Single	8JRV	Glucagon	8JRV-Glucagon-Glucagon-Arrestin2
14.29	Consensus	p2y1_off	Orthosteric Ligand	4XNW-P2Y₁-MRS2500
14.29	Consensus	smo_off_allo	Orthosteric Ligand	6D32-SMO-Cyclopamine-Cyclopamine
12.50	Single	3V2W	PubChem 51892645	3V2W-S1P₁-PubChem 51892645
12.50	Single	4O9R	Cyclopamine	4O9R-SMO-Cyclopamine
12.50	Single	7VDH	C48/80	7VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
12.50	Single	8U4R	REGN7663-Fab	8U4R-CXCR4-REGN7663-Fab-Cholesterol
12.50	Consensus	go_chemokine	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
12.50	Consensus	go_protein	Orthosteric Ligand	go_chemokine
12.50	Consensus	smo_on_allo	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
11.11	Single	4BWB	Neurotensin	4BWB-NTS₁-Neurotensin
11.11	Single	4QIN	SAG1.5	4QIN-SMO-SAG1.5
11.11	Single	5U09	Taranabant	5U09-CB₁-Taranabant
11.11	Single	6LFO	Interleukin-8	6LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
11.11	Single	6O3C	SAG21k	6O3C-SMO-SAG21k-Cholesterol
11.11	Single	6PWC	Neurotensin	6PWC-NTS₁-Neurotensin-Arrestin2
11.11	Single	6WWZ	CCL20	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11	Single	7BR3	Elagolix	7BR3-GnRH₁-Elagolix
11.11	Single	7LCJ	Danuglipron	7LCJ-GLP-1-Danuglipron
11.11	Single	7VIH	CBP-307	7VIH-S1P₁-CBP-307-Gi1/&β;1/&γ;2
11.11	Single	7VV5	C48/80	7VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
11.11	Single	7WF7	S1P	7WF7-S1P₁-S1P-Gi1/&β;1/&γ;2
11.11	Single	8FN0	Neurotensin/neuromedin N	8FN0-NTS₁-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
11.11	Single	8HMP	PubChem 69921479	8HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
11.11	Consensus	ccr6_on	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
11.11	Consensus	class-f_off	Orthosteric Ligand	smo_off
11.11	Consensus	cxcr1_on	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
11.11	Consensus	gnrh1_off	Orthosteric Ligand	7BR3-GnRH₁-Elagolix
11.11	Consensus	p2y_off	Orthosteric Ligand	p2y1_off p2y12_off
10.00	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
10.00	Single	6XBL	SAG	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00	Single	7C2E	PubChem 149050799	7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
10.00	Single	7UTZ	PubChem 644078	7UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
10.00	Single	7VV6	C48/80	7VV6-MRGPRX2-C48/80
10.00	Single	7XXH	2MeSADP	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
10.00	Single	7ZI0	SAG	7ZI0-SMO-SAG-Cholesterol
10.00	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
10.00	Consensus	cb1_off	Orthosteric Ligand	5TGZ-CB₁-AM6538 5U09-CB₁-Taranabant
10.00	Consensus	cxcr2_on	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
10.00	Consensus	cxcr_on	Orthosteric Ligand	cxcr1_on cxcr2_on
10.00	Consensus	gi_class-f	Orthosteric Ligand	gi_frizzled
10.00	Consensus	gi_frizzled	Orthosteric Ligand	6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
10.00	Consensus	gnrh_off	Orthosteric Ligand	gnrh1_off
10.00	Consensus	lh_on_allo	Other Ligand	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
10.00	Consensus	s1p1_off	Orthosteric Ligand	3V2Y-S1P₁-PubChem 51892645
10.00	Consensus	s1p_off	Orthosteric Ligand	s1p1_off
9.09	Single	4QIM	PubChem 24905375	4QIM-SMO-PubChem 24905375
9.09	Single	5T04	Neurotensin	5T04-NTS₁-Neurotensin
9.09	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
9.09	Single	6D27	CAY10471	6D27-DP₂-CAY10471
9.09	Single	6X1A	Danuglipron	6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
9.09	Single	6Z4V	NTS8-13	6Z4V-NTS₁-NTS8-13
9.09	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
9.09	Single	7LCI	Danuglipron	7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
9.09	Single	7LCK	Danuglipron	7LCK-GLP-1-Danuglipron
9.09	Single	7S15	PubChem 134611223	7S15-GLP-1-PubChem 134611223
9.09	Single	7SK8	CXCL12	7SK8-ACKR3-CXCL12-CCX662
9.09	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/&β;1/&γ;2
9.09	Single	7VIF	(S)-FTY720-P	7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2
9.09	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
9.09	Single	8IC0	Interleukin-8	8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
9.09	Single	8ID4	Linoleic acid	8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
9.09	Consensus	fsh_on_allo	Other Ligand	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
9.09	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off leuko_off lpl_off paf_off prostanoid_off
9.09	Consensus	nucleotide_off	Orthosteric Ligand	adenosine_off p2y_off
9.09	Consensus	smo_off	Orthosteric Ligand	5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
8.33	Single	4JKV	Taladegib (LY2940680)	4JKV-SMO-Taladegib (LY2940680)
8.33	Single	5C1M	BU72	5C1M-μ-BU72
8.33	Single	6LFM	Interleukin-8	6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
8.33	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
8.33	Single	7BB7	Acyclovir triphosphate	7BB7-V₂-Acyclovir triphosphate-Gs/&β;1/&γ;2
8.33	Single	7C4S	S1P	7C4S-S1P₃-S1P
8.33	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/&β;1/&γ;2
8.33	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2
8.33	Single	7T9N	PubChem 644078	7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
8.33	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2
8.33	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
8.33	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
8.33	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
8.33	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
8.33	Single	8FN1	Neurotensin/neuromedin N	8FN1-NTS₁-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
8.33	Single	8JPC	Neurotensin 8-13	8JPC-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.69	Single	3ZEV	Neurotensin	3ZEV-NTS₁-Neurotensin
7.69	Single	4BV0	Neurotensin	4BV0-NTS₁-Neurotensin
7.69	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
7.69	Single	5V56	TC114	5V56-SMO-TC114
7.69	Single	5V57	TC114	5V57-SMO-TC114
7.69	Single	6OS1	TRV026	6OS1-AT₁-TRV026
7.69	Single	6UP7	Neurotensin	6UP7-NTS₁-Neurotensin-Arrestin2
7.69	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
7.69	Single	7F1T	MIP-1a	7F1T-CCR5-MIP-1a
7.69	Single	7F58	THIQ	7F58-MC₄-THIQ-Gs/&β;1/&γ;2
7.69	Single	7L0P	Neurotensin	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
7.69	Single	7L0Q	Neurotensin	7L0Q-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
7.69	Single	7R0C	Acyclovir triphosphate	7R0C-V₂-Acyclovir triphosphate-Arrestin2
7.69	Single	7SK7	CXCL12	7SK7-ACKR3-CXCL12-CCX662
7.69	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/&β;1/&γ;2
7.69	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2
7.69	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
7.69	Single	8E0G	BU72	8E0G-μ-BU72
7.69	Single	8FMZ	Neurotensin/neuromedin N	8FMZ-NTS₁-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.69	Single	8HQC	C5a anaphylatoxin	8HQC-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
7.69	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
7.69	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
7.69	Single	8ID6	Oleic acid	8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
7.69	Consensus	arrestin2	Orthosteric Ligand	6TKO-β₁-Arformoterol-Arrestin2 6PWC-NTS₁-Neurotensin-Arrestin2 7R0C-V₂-Acyclovir triphosphate-Arrestin2
7.69	Consensus	class-a_off	Orthosteric Ligand	sensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
7.69	Consensus	lpa1_on	Orthosteric Ligand	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
7.69	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
7.69	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
7.69	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
7.69	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/&β;1/&γ;2
7.14	Single	4GRV	Neurotensin 8-13	4GRV-NTS₁-Neurotensin 8-13
7.14	Single	4XEE	Neurotensin	4XEE-NTS₁-Neurotensin
7.14	Single	4XES	Neurotensin	4XES-NTS₁-Neurotensin
7.14	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/&β;1/&γ;2
7.14	Single	6OS0	Angiotensinogen	6OS0-AT₁-Angiotensinogen
7.14	Single	6OS2	TRV026	6OS2-AT₁-TRV026
7.14	Single	6OSA	JMV449	6OSA-NTS₁-JMV449-Gi1/&β;1/&γ;2
7.14	Single	6XOX	Orforglipron	6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
7.14	Single	6YVR	NTS8-13	6YVR-NTS₁-NTS8-13
7.14	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/&β;1/&γ;2
7.14	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2
7.14	Single	7L0S	Neurotensin	7L0S-NTS₁-Neurotensin-Gi1/&β;1/γ1
7.14	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
7.14	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
7.14	Single	8IBU	Erythromycin A	8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.14	Single	8JPB	Neurotensin 8-13	8JPB-NTS₁-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
7.14	Single	8T3Q	DHA	8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
7.14	Single	8U26	Protachykinin-1	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2
7.14	Consensus	cannabinoid_off	Orthosteric Ligand	cb1_off cb2_off
7.14	Consensus	chemokine_off	Orthosteric Ligand	cxcr_off
7.14	Consensus	cxcr4_off	Orthosteric Ligand	4RWS-CXCR4-vMIP-II
7.14	Consensus	cxcr_off	Orthosteric Ligand	cxcr4_off
7.14	Consensus	dp2_off	Orthosteric Ligand	6D27-DP₂-CAY10471 6D26-DP₂-Fevipiprant
7.14	Consensus	dp_off	Orthosteric Ligand	dp2_off
7.14	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z34-LPA₁-ONO-9780307 4Z35-LPA₁-ONO-9910539 7YU4-LPA₁-ONO-0740556
7.14	Consensus	mop_on	Orthosteric Ligand	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
7.14	Consensus	nts1_on	Orthosteric Ligand	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
7.14	Consensus	nts_on	Orthosteric Ligand	nts1_on
7.14	Consensus	s1p_on	Orthosteric Ligand	s1p3_on s1p5_on s1p1_on s1p2_on
7.14	Consensus	tsh_on_allo	Other Ligand	7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
6.67	Single	4BUO	Neurotensin	4BUO-NTS₁-Neurotensin
6.67	Single	4RWS	vMIP-II	4RWS-CXCR4-vMIP-II
6.67	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
6.67	Single	6M1H	Maxadilan	6M1H-PAC₁-Maxadilan-Gs/&β;1/&γ;2
6.67	Single	6OS9	JMV449	6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
6.67	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2
6.67	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2
6.67	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
6.67	Single	7P00	Substance P	7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.67	Single	7X8R	BOC5	7X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
6.67	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2
6.67	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
6.67	Single	8JPF	Neurotensin	8JPF-NTS₁-Neurotensin-PubChem 118610427
6.67	Consensus	class-a_on	Orthosteric Ligand	sensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
6.67	Consensus	gi_class-a	Orthosteric Ligand	gi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
6.67	Consensus	gi_neurotensin	Orthosteric Ligand	7L0P-NTS₁-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS₁-JMV449-Gi1/&β;1/&γ;2
6.67	Consensus	s1p1_on	Orthosteric Ligand	7TD3-S1P₁-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
6.25	Single	6KNM	JN241-9	6KNM-Apelin-JN241-9
6.25	Single	7RKF	Fractalkine	7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
6.25	Single	7RKN	Fractalkine	7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
6.25	Single	7RMG	Substance P	7RMG-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
6.25	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
6.25	Single	7X8S	WB4-24	7X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
6.25	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
6.25	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	chemokine_on	Orthosteric Ligand	cxcr_on cx3cr_on
6.25	Consensus	gi_apelin	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
6.25	Consensus	go_compl-peptide	Orthosteric Ligand	8I95-C3a_B-EP54-Go/&β;1/&γ;2 8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3a_B-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3a_B-EP141-Go/&β;1/&γ;2
6.25	Consensus	go_ghrelin	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
6.25	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
6.25	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
6.25	Consensus	mc4_on	Orthosteric Ligand	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC₄-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC₄-THIQ-Gs/&β;1/&γ;2 7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
6.25	Consensus	motilin_on	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	nk1_on	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
6.25	Consensus	protein_on	Orthosteric Ligand	ccr_on chemokine_on gphr_on chemerin_on
5.88	Single	4XT1	Fractalkine	4XT1-US28-Fractalkine
5.88	Single	5VBL	Apelin Mimetic Peptide Agonist	5VBL-Apelin-Apelin Mimetic Peptide Agonist
5.88	Single	6X19	CHU-128	6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
5.88	Single	7F54	Afamelanotide	7F54-MC₄-Afamelanotide-Gs/&β;1/&γ;2
5.88	Single	7L0R	Neurotensin	7L0R-NTS₁-Neurotensin-Gi1/&β;1/&γ;1
5.88	Single	7RMH	Substance P	7RMH-NK₁-Substance P-Gs/&β;1/&γ;2
5.88	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
5.88	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2
5.88	Single	7VLA	CCL15(27-92)	7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
5.88	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
5.88	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
5.88	Single	8JZZ	C5a-desArg	8JZZ-C5a₁-C5a-desArg-Go/&β;1/&γ;2
5.88	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
5.88	Consensus	apelin_on	Orthosteric Ligand	7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
5.88	Consensus	gi_opioid	Orthosteric Ligand	8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
5.88	Consensus	go_class-a	Orthosteric Ligand	go_amine go_peptide go_protein
5.88	Consensus	protein_off	Orthosteric Ligand	ccr_off chemokine_off gnrh_off
5.56	Single	6DO1	Angiotensin-Like peptide S1I8	6DO1-AT₁-Angiotensin-Like peptide S1I8
5.56	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
5.56	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
5.56	Single	7E14	Orforglipron	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
5.56	Single	7F1Q	MIP-1a	7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
5.56	Single	7PIV	Setmelanotide	7PIV-MC₄-Setmelanotide-Gs/&β;1/&γ;2
5.56	Single	7RKM	Fractalkine	7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
5.56	Single	7RMI	Substance P	7RMI-NK₁-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
5.56	Single	7SK5	CXCL12	7SK5-ACKR3-CXCL12
5.56	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
5.56	Single	8F7Q	Beta-endorphin	8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
5.56	Single	8IBV	Motilin	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56	Single	8IOC	Gamma-MSH	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.56	Consensus	gi_lpl	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/&β;1/&γ;2 7TD4-S1P₁-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P₁-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P₁-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P₁-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P₁-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P₃-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P₃-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2 7YU3-LPA₁-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P₁-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P₁-PubChem 4077460-Gi1/&β;1/&γ;2
5.56	Consensus	vasopressin-ot_on	Orthosteric Ligand	ot_on v2_on
5.26	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
5.26	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
5.26	Single	7O7F	(6P4)CCL5	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
5.26	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/&β;1/&γ;2
5.26	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/&β;1/&γ;2
5.26	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/&β;1/&γ;2
5.26	Single	7XA3	CCL2	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.26	Single	8XZH	MM07	8XZH-Apelin-MM07-Gi1/&β;1/&γ;2
5.26	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
5.26	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
5.26	Consensus	ccr2_on	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
5.26	Consensus	ccr_off	Orthosteric Ligand	ccr5_off ccr8_off
5.26	Consensus	go_peptide	Orthosteric Ligand	go_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
5.26	Consensus	gs_class-a	Orthosteric Ligand	gs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
5.26	Consensus	gs_motilin	Orthosteric Ligand	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Consensus	gs_tachykinin	Orthosteric Ligand	8U26-NK₁-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK₁-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
5.26	Consensus	opioid_on	Orthosteric Ligand	kop_on mop_on nop_on dop_on
5.26	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on
5.00	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
5.00	Single	5YQZ	Glucagon analogue	5YQZ-Glucagon-Glucagon analogue
5.00	Single	6M1I	PACAP	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
5.00	Single	6MEO	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00	Single	6MET	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
5.00	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
5.00	Single	7DW9	Acyclovir triphosphate	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Single	7F6G	SAR1-AngII	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
5.00	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
5.00	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
5.00	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.00	Single	7YON	Peptide YY(3-36)	7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
5.00	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.00	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
5.00	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
5.00	Single	8IA2	C5a anaphylatoxin	8IA2-C5a₁-C5a anaphylatoxin-Go/&β;1/&γ;2
5.00	Single	8XZJ	WN353	8XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
5.00	Consensus	bk2_on	Orthosteric Ligand	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
5.00	Consensus	ccr1_on	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
5.00	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
5.00	Consensus	ghrelin_on	Orthosteric Ligand	7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
5.00	Consensus	go_class-b	Orthosteric Ligand	go_class-b1 go_class-b2
5.00	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/&β;1/&γ;2
5.00	Consensus	pca1_on	Orthosteric Ligand	6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2
5.00	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.76	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.76	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2
4.76	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
4.76	Single	7F9Y	Ghrelin-28	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
4.76	Single	7P02	Protachykinin-1	7P02-NK₁-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
4.76	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
4.76	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
4.76	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.76	Single	7X9B	Neuropeptide Y	7X9B-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
4.76	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
4.76	Single	7Y64	C5a anaphylatoxin	7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.76	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.76	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2
4.76	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Single	8HK5	Complement C5	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2
4.76	Consensus	c5a1_on	Orthosteric Ligand	7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.76	Consensus	crf2_on	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.76	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Consensus	gq_class-a	Orthosteric Ligand	gq_amine gq_peptide
4.76	Consensus	gs_ghrelin	Orthosteric Ligand	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76	Consensus	vpac1_on	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
4.55	Single	4XT3	Fractalkine	4XT3-US28-Fractalkine
4.55	Single	5UIW	5P7-CCL5	5UIW-CCR5-5P7-CCL5
4.55	Single	6FJ3	PTH	6FJ3-PTH1-PTH
4.55	Single	6NBF	Long-acting PTH analog	6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.55	Single	6NBI	Long-acting PTH analog	6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.55	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
4.55	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
4.55	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	7SK3	CXCL12	7SK3-ACKR3-CXCL12
4.55	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
4.55	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/&β;1/&γ;2
4.55	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.55	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on bk1_on
4.55	Consensus	ccr5_off	Orthosteric Ligand	5UIW-CCR5-5P7-CCL5
4.55	Consensus	ccr5_on	Orthosteric Ligand	7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
4.55	Consensus	ctlike_on	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.55	Consensus	gi_compl-peptide	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3a_B-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a₁-BM213-Gi1/&β;1/&γ;2 7Y67-C5a₁-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3a_B-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a₁-C5a peptide-Gi1/&β;1/&γ;2
4.55	Consensus	glp1_on_allo	Orthosteric Ligand	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.55	Consensus	gs_vasopressin-ot	Orthosteric Ligand	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V₂-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.55	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2
4.35	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
4.35	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
4.35	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
4.35	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.35	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/&β;1/&γ;2
4.35	Single	7F53	Alpha-MSH	7F53-MC₄-Alpha-MSH-Gs/&β;1/&γ;2
4.35	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
4.35	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.35	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.35	Single	7YOO	Neuropeptide Y	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2
4.35	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
4.35	Consensus	ccr8_on	Orthosteric Ligand	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.35	Consensus	ccr_on	Orthosteric Ligand	ccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
4.35	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
4.35	Consensus	glp2_on	Orthosteric Ligand	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.35	Consensus	go_class-b1	Orthosteric Ligand	go_crf
4.35	Consensus	go_crf	Orthosteric Ligand	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.35	Consensus	gs_cgrp	Orthosteric Ligand	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.17	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
4.17	Single	6LML	Glucagon	6LML-Glucagon-Glucagon
4.17	Single	6NBH	Long-acting PTH analog	6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.17	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
4.17	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.17	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
4.17	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
4.17	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
4.17	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/&β;1/&γ;2
4.17	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/&β;1/&γ;2
4.17	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
4.17	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/&β;1/&γ;2
4.17	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
4.17	Consensus	calcitonin_on	Orthosteric Ligand	ct_on ctlike_on
4.17	Consensus	crf_on	Orthosteric Ligand	crf2_on crf1_on
4.17	Consensus	gi_chemokine	Orthosteric Ligand	7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
4.17	Consensus	glp1_on	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
4.17	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK₂-Kallidin-Gq/&β;1/&γ;2
4.17	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_angiotensin gq_bombesin gq_bradykinin
4.17	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
4.17	Consensus	peptide_on	Orthosteric Ligand	opioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
4.17	Consensus	secretin_on	Orthosteric Ligand	6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
4.17	Consensus	vpac2_on	Orthosteric Ligand	7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2
4.00	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
4.00	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.00	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
4.00	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
4.00	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
4.00	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.00	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
4.00	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/&β;1/&γ;2
4.00	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/&β;1/&γ;2
4.00	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
4.00	Single	7TYX	Amylin	7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
4.00	Consensus	gi_peptide	Orthosteric Ligand	gi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
4.00	Consensus	gip_on	Orthosteric Ligand	7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
4.00	Consensus	gip_on_allo	Orthosteric Ligand	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.85	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/&β;1/&γ;1
3.85	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
3.85	Single	7SK6	CXCL12_LRHQ	7SK6-ACKR3-CXCL12_LRHQ
3.85	Single	7TYH	Calcitonin-1	7TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.85	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
3.85	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
3.85	Single	8FLU	Long-acting PTH	8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
3.85	Consensus	glp_on	Orthosteric Ligand	glp1_on glp2_on
3.85	Consensus	melanocortin_on	Orthosteric Ligand	mc2_on mc1_on mc3_on mc4_on mc5_on
3.70	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
3.70	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
3.70	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
3.70	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.70	Single	8F0K	Pramlintide analogue san385	8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.70	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
3.70	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
3.70	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
3.70	Consensus	pth1_on	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.70	Consensus	vip-pacap_on	Orthosteric Ligand	vpac1_on vpac2_on pca1_on
3.57	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.57	Single	7X9A	Neuropeptide Y	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
3.57	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
3.57	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
3.57	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.57	Consensus	gi_neuropeptide	Orthosteric Ligand	7YOO-Y₂-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y₂-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y₄-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57	Consensus	gs_glucagon	Orthosteric Ligand	6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.57	Consensus	gs_vip-pacap	Orthosteric Ligand	8E3Y-VPAC₁-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC₁-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC₁-VIP-Gs/&β;1/&γ;2 6M1I-PAC₁-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC₁-PACAP-Gs/&β;1/&γ;2
3.57	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
3.57	Consensus	npy1_on	Orthosteric Ligand	7X9A-Y₁-Neuropeptide Y-Gi1/&β;1/&γ;2
3.57	Consensus	npy_on	Orthosteric Ligand	npy2_on npy4_on npy1_on
3.57	Consensus	pth2_on	Orthosteric Ligand	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.45	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.45	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.45	Consensus	gs_class-b	Orthosteric Ligand	gs_class-b1 gs_class-b2
3.45	Consensus	pth_on	Orthosteric Ligand	pth1_on pth2_on
3.33	Single	8F2A	Pramlintide analogue san385	8F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.33	Consensus	ct_on	Orthosteric Ligand	7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
3.23	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.23	Consensus	glucagon_on	Orthosteric Ligand	gip_on glu_on secretin_on ghrh_on glp_on
3.23	Consensus	gs_pth	Orthosteric Ligand	8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
3.12	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
3.12	Consensus	class-b1_on	Orthosteric Ligand	glucagon_on calcitonin_on vip-pacap_on pth_on crf_on
3.12	Consensus	glu_on	Orthosteric Ligand	6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
3.03	Single	8F2B	Pramlintide analogue san45	8F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
3.03	Consensus	gs_calcitonin	Orthosteric Ligand	gs_ct gs_cgrp
3.03	Consensus	gs_ct	Orthosteric Ligand	7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.94	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
2.94	Consensus	gs_class-b1	Orthosteric Ligand	gs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
2.86	Single	8F0J	Pramlintide analogue san45	8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

PDB Summary
PDB	6D35
Class	F
SubFamily	Protein
Type	Frizzled
SubType	SMO
Species	Xenopus laevis
Ligand	-
Other Ligand(s)	Cholesterol
Protein Partners	-
PDB Resolution	3.9
Date	2018-05-23
D.O.I.	10.1016/j.cell.2018.04.029

Net Summary
I_min	2.85
Number of Linked Nodes	431
Number of Links	534
Number of Hubs	92
Number of Links mediated by Hubs	314
Number of Communities	15
Number of Nodes involved in Communities	135
Number of Links involved in Communities	198

Path Summary
Number Of Nodes in MetaPath	94
Number Of Links MetaPath	93
Number of Shortest Paths	280633
Length Of Smallest Path	3
Average Path Length	19.5112
Length of Longest Path	38
Minimum Path Strength	1.355
Average Path Strength	6.48936
Maximum Path Strength	23.69
Minimum Path Correlation	0.7
Average Path Correlation	0.961616
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	56.9882
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	53.4032
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	CLR
PDB Residues	W:W:?3
Environment Details	Open EMBL-EBI Page
Code	CLR
Name	Cholesterol
Synonyms	Cholest-5-en-3beta-ol Cholesterin (3β,14β,17α)-cholest-5-en-3-ol Cholesterol
Identifier	(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
Formula	C27 H46 O
Molecular Weight	386.654
SMILES	CC(C)CCC[C@@H](C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C
PubChem	5997
Formal Charge	0
Total Atoms	74
Total Chiral Atoms	8
Total Bonds	77
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	A0A1L8GTP2
Sequence	>6D35_Chain_R K C K K T T T C E P L K Y N I C L G S V L P Y A L T S T V L A E D S S S Q D E V H D K L S L W S G L R N A P R C W D A I R P L L C A V Y M P K C E G G K V E L P S Q G L C Q T T R V P C A I V A R E R G W P D F L K C T T D Y F P E G C P N E V Q N I K F N S A G Q C E A P L V R T D N P K S W Y E D V E G C G I Q C Q N P L F T N K E H R E M H I Y I A I F S S V T I F C T F F T L A T F L V D W K N S N R Y P A V I L F Y V N A C F F A G S I G W L A Q F M D G A R D E I V C R G D G T M R L G E P T S S E T L S C V I I F I I V Y Y S M M S G V I W F V M L T Y A W H T S F K A L S G K T S Y F H L I T W S I P F V L T V A I L A V A Q V D G D S V S G I C F V G Y K N Y H Y R A G F V L A P I G L V L I G G G Y F L I R G V M T L F S S K I N E T M L R L G I F G F L A F G F V L I T F G C H F Y D F F N Q A E W E R S F R E Y V L C E A N V A I A E Q T N K P I P E C Y I K N R P S L L V E K I N L F A M F G T G I S M S T W V W T K A T I I I W K R A W C R I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	4JKV	F	Protein	Frizzled	SMO	Homo sapiens	Taladegib (LY2940680)	-	-	2.45	2013-04-24	10.1038/nature12167
	4N4W	F	Protein	Frizzled	SMO	Homo sapiens	-	SANT-1	-	2.8	2014-01-22	10.1038/ncomms5355
	4O9R	F	Protein	Frizzled	SMO	Homo sapiens	Cyclopamine	-	-	3.2	2014-03-05	10.1038/ncomms4309
	4QIM	F	Protein	Frizzled	SMO	Homo sapiens	PubChem 24905375	-	-	2.61	2014-07-23	10.1038/ncomms5355
	4QIN	F	Protein	Frizzled	SMO	Homo sapiens	SAG1.5	-	-	2.6	2014-07-23	10.1038/ncomms5355
	5L7D	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol	-	3.2	2016-07-20	10.1038/nature18934
	5L7I	F	Protein	Frizzled	SMO	Homo sapiens	Vismodegib	-	-	3.3	2016-07-20	10.1038/nature18934
	5V56	F	Protein	Frizzled	SMO	Homo sapiens	TC114	-	-	2.9	2017-05-24	10.1038/ncomms15383
	5V57	F	Protein	Frizzled	SMO	Homo sapiens	TC114	-	-	3	2017-05-24	10.1038/ncomms15383
	6D32	F	Protein	Frizzled	SMO	Xenopus laevis	Cyclopamine	Cyclopamine	-	3.75	2018-05-23	10.1016/j.cell.2018.04.029
	6D35	F	Protein	Frizzled	SMO	Xenopus laevis	-	Cholesterol	-	3.9	2018-05-23	10.1016/j.cell.2018.04.029
	6O3C	F	Protein	Frizzled	SMO	Mus musculus	SAG21k	Cholesterol	-	2.8	2019-07-03	10.1038/s41586-019-1355-4
	6OT0	F	Protein	Frizzled	SMO	Homo sapiens	-	25(S)-Epoxycholesterol	Gi1/&β;1/&γ;2	3.84	2019-06-12	10.1038/s41586-019-1286-0
	6XBJ	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol	Gi1/&β;1/&γ;2	3.88	2020-09-30	10.1038/s41589-020-0646-2
	6XBK	F	Protein	Frizzled	SMO	Homo sapiens	-	Cholesterol	Gi1/&β;1/&γ;2	3.24	2020-09-30	10.1038/s41589-020-0646-2
	6XBL	F	Protein	Frizzled	SMO	Homo sapiens	SAG	Cholesterol	Gi1/&β;1/&γ;2	3.96	2020-09-30	10.1038/s41589-020-0646-2
	6XBM	F	Protein	Frizzled	SMO	Homo sapiens	-	25(S)-Epoxycholesterol	Gi1/&β;1/&γ;2	3.14	2020-09-30	10.1038/s41589-020-0646-2
	7ZI0	F	Protein	Frizzled	SMO	Homo sapiens	SAG	Cholesterol	-	3	2022-06-15	10.1126/sciadv.abm5563
	8CXO	F	Protein	Frizzled	SMO	Mus musculus	-	-	-	3.7	2022-08-03	10.1038/s41467-022-32125-2
	4JKV (Dimer)	F	Protein	Frizzled	SMO	Homo sapiens	Taladegib (LY2940680)	-	-	2.45	2013-04-24	10.1038/nature12167

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