Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:?17 4.745403
2A:A:?34 4.71415
3A:A:?37 9.38571713
4A:A:H41 5.672536
5A:A:L44 10.1975419
6A:A:N50 5.8725229
7A:A:?53 6.79409
8A:A:?63 5.8075409
9A:A:F212 8.838509
10A:A:Q227 8.4325419
11A:A:R228 8.0725419
12A:A:R232 8.425418
13A:A:?233 5.0125419
14A:A:W234 8.5325409
15A:A:?237 8.716518
16A:A:?253 7.166199
17A:A:F273 7.4425439
18A:A:W277 9.65833636
19A:A:W281 8.038515
20A:A:F290 7.2275489
21A:A:N292 5.424589
22A:A:Q294 7.9425436
23A:A:?300 4.4525409
24A:A:?311 13.78336195
25A:A:?318 11.6714737
26A:A:E330 5.798503
27A:A:D331 8.8475404
28A:A:?338 8.396535
29A:A:?339 10.62633
30A:A:F340 8.2575406
31A:A:R342 7.83333635
32A:A:F345 7.3025438
33A:A:?358 10.5962834
34A:A:?359 18.5325436
35A:A:?360 14.8788838
36A:A:F363 7.91435
37A:A:T364 9.062589
38A:A:?365 9.30833687
39A:A:R373 6.5275436
40A:A:?379 5.3925439
41A:A:I382 5.658537
42A:A:?391 8.96333664
43B:B:L7 5.8408
44B:B:N16 8.31401
45B:B:I18 4.4825407
46B:B:?25 4.352503
47B:B:V40 6.2025473
48B:B:R49 5.1525407
49B:B:L51 9.5409
50B:B:H54 7.65286719
51B:B:I58 6.9325419
52B:B:?59 10.4414718
53B:B:M61 5.79416
54B:B:W63 8.47167617
55B:B:Q75 13.3825419
56B:B:D76 7.98667619
57B:B:?77 8.265418
58B:B:L79 4.715407
59B:B:W82 8.59571719
60B:B:?85 14.27836204
61B:B:N88 7.3925407
62B:B:I93 4.84457
63B:B:L95 6.2475408
64B:B:W99 10.9067619
65B:B:M101 5.2975419
66B:B:?103 6.442508
67B:B:?105 9.07444956
68B:B:?109 6.6525455
69B:B:N110 7.8675454
70B:B:?111 7.532731154
71B:B:V112 5.854558
72B:B:?114 7.825658
73B:B:L117 5.8175419
74B:B:?121 6.97458
75B:B:I123 5.1456
76B:B:?124 7.835856
77B:B:L139 4.4725409
78B:B:H142 7.644519
79B:B:?144 11.466518
80B:B:?145 9.794551118
81B:B:L146 6.6575457
82B:B:?148 12.3017656
83B:B:?149 13.62558
84B:B:F151 7.978559
85B:B:D154 6.408556
86B:B:S161 8.916519
87B:B:?162 9.658519
88B:B:D163 8.915619
89B:B:T165 7.84417
90B:B:W169 7.555408
91B:B:D170 3.915409
92B:B:F180 10.756517
93B:B:H183 7.142519
94B:B:?185 7.9375415
95B:B:D186 8.306519
96B:B:V200 8.6675416
97B:B:?204 9.15833617
98B:B:D205 6.2875419
99B:B:?209 8.9925416
100B:B:W211 10.0514718
101B:B:H225 11.3417619
102B:B:I232 7.17418
103B:B:?233 7.905403
104B:B:F234 8.605405
105B:B:F235 9.02833676
106B:B:P236 7.04477
107B:B:N237 12.92475
108B:B:?238 5.3025477
109B:B:N239 11.525472
110B:B:F241 9.292516
111B:B:T243 7.6675418
112B:B:D247 10.305419
113B:B:?250 13.5175418
114B:B:R251 14.58518
115B:B:F253 9.17516
116B:B:D254 6.4425409
117B:B:D258 10.21417
118B:B:?264 15.0283605
119B:B:I269 4.135414
120B:B:?271 9.81515
121B:B:I273 7.735416
122B:B:F278 7.26333677
123B:B:?282 5.18667679
124B:B:R283 8.9579
125B:B:?289 10.7791017
126B:B:D290 8.648516
127B:B:N293 6.39415
128B:B:?294 7.46415
129B:B:N295 11.69416
130B:B:W297 10.5375418
131B:B:R304 8.326515
132B:B:H311 8.5565109
133B:B:R314 10.928518
134B:B:?317 7.64833617
135B:B:T321 8.35417
136B:B:D323 6.88417
137B:B:?324 7.1025419
138B:B:W332 9.33619
139B:B:D333 7.01409
140B:B:?337 5.981437106
141B:B:W339 9.081676109
142G:G:?20 4.2625406
143G:G:?40 13.5486776
144G:G:?41 9.182577
145G:G:D48 7.35409
146G:G:N59 6.874509
147G:G:F61 6.6125408
148R:R:?58 12.59405
149R:R:?62 5.415404
150R:R:I64 5.78407
151R:R:Q82 10.9675406
152R:R:F94 7.3075409
153R:R:D95 8.054126
154R:R:L100 5.7375409
155R:R:N107 11.0575427
156R:R:?113 10.3025401
157R:R:I114 5.3925408
158R:R:I120 6.54254125
159R:R:?126 8.36405
160R:R:?127 10.9083626
161R:R:L128 5.7725408
162R:R:?131 11.124527
163R:R:N132 5.378528
164R:R:T133 7.9925428
165R:R:?134 6.63405
166R:R:I135 5.5425407
167R:R:F138 6.35254265
168R:R:D140 5.61754123
169R:R:?143 8.2685124
170R:R:F151 8.005405
171R:R:I152 5.3025424
172R:R:E154 8.862527
173R:R:I155 5.6875428
174R:R:?156 16.1867627
175R:R:N158 7.67833629
176R:R:?166 6.255404
177R:R:Q170 11.22754153
178R:R:N173 5.19404
179R:R:L181 4.7975408
180R:R:?182 12.1675826
181R:R:?183 8.7325427
182R:R:N184 9.62714729
183R:R:F186 10.436528
184R:R:H192 6.43405
185R:R:F194 8.635409
186R:R:N195 14.0965155
187R:R:L202 6.56407
188R:R:H209 6.7425401
189R:R:F218 10.085408
190R:R:?223 7.14254167
191R:R:P224 8.9925408
192R:R:L227 4.57254148
193R:R:I229 4.38407
194R:R:?240 14.3745162
195R:R:?241 11.7425167
196R:R:?254 9.295282
197R:R:L256 3.895408
198R:R:P260 5.5275406
199R:R:F265 7.63754147
200R:R:?275 14.17336288
201R:R:F282 7.615148
202R:R:?333 13.34754171
203R:R:?336 9.3885176
204R:R:E354 8.555407
205R:R:D355 7.845447
206R:R:?359 13.685446
207R:R:R363 9.558549
208R:R:I366 5.36549
209R:R:?376 4.4975467
210R:R:N377 8.6375469
211R:R:?389 14.20297113
212R:R:N400 8.90254217
213R:R:L401 6.26668
214R:R:D405 8.096569
215R:R:?407 6.9025447
216R:R:?411 7.4051047
217R:R:D419 9.955449
218R:R:?426 12.25299
219R:R:?427 14.2754297
220R:R:W433 14.39449
221R:R:?438 11.48448
222R:R:?439 16.014549
223R:R:?455 8.994508
224R:R:R464 9.8175468
225R:R:?470 7.45403
226R:R:I472 6.884535
227R:R:M487 8.124217
228R:R:?490 8.7625408
229R:R:W491 7.1445215
230R:R:?508 10.7244948
231R:R:?514 10.3367649
232R:R:F515 6.65649
233R:R:?527 8.60143707
234R:R:L532 3.32409
235R:R:?543 7.44667667
236R:R:?545 10.0583666
237R:R:?546 10.7711069
238R:R:?550 5.66167669
239R:R:N555 7.7625437
240R:R:?581 6.115649
241R:R:?612 8.61833647
242R:R:?617 6.02509
243R:R:N619 7.845469
244R:R:L622 4.5575409
245R:R:?623 7.05333669
246R:R:F630 6.215408
247R:R:D633 9.65254118
248L:L:?31 14.614520
249L:L:?34 9.08520
250L:L:N39 6.3525300
251L:L:F41 9.8254300
252L:L:I49 4.4375400
253L:L:?52 8.49667620
254L:L:?55 17.73520
255L:L:?56 19.94420
256L:L:?61 10.3556990
257L:L:T63 5.8025420
258L:L:?68 6.954520
259L:L:?69 5.315400
260L:L:M71 6.108520
261L:L:V77 4.4725490
262L:L:?83 13.805620
263L:L:?84 10.845620
264L:L:V85 4.695420
265L:L:S88 4.4454130
266L:L:?89 8.3654130
267L:L:F98 5.3425340
268L:L:H103 8.7425400
269L:L:?108 11.6283620
270L:L:?111 14.635620
271L:L:?112 13.7256920
272L:L:?113 15.172520
273L:L:H114 11.02620
274L:L:?115 6.18833620
275M:M:?43 13.585180
276M:M:?46 11.095400
277M:M:?54 10.654500
278M:M:?57 17.1675820
279M:M:?58 14.76620
280M:M:Q74 9.13420
281M:M:?77 8.2775400
282M:M:?79 10.2543790
283M:M:R80 8.6675420
284M:M:L89 6.84180
285M:M:?92 16.38254180
286M:M:?102 9.475400
287M:M:?108 7.76520
288M:M:Q109 6.845420
289M:M:?110 9.155420
290M:M:R115 9.8525420
291M:M:?120 8.765620
292M:M:?124 6.44400
293M:M:?130 10.175400
294H:H:?2 17.18754150
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:?59 B:B:I58 10.54755.55YesYes189
2A:A:?237 B:B:?59 1007.21YesYes188
3A:A:?237 B:B:W99 1007.32YesYes189
4A:A:F222 B:B:W99 10023.05NoYes069
5B:B:?59 B:B:Q75 10019.42YesYes189
6B:B:Q75 B:B:W99 1009.86YesYes199
7A:A:E209 A:A:F222 1008.16NoNo096
8A:A:?211 A:A:E209 1007.11NoNo049
9A:A:?211 A:A:F212 1004.36NoYes049
10A:A:F212 A:A:F219 10017.15YesNo098
11A:A:F219 A:A:H41 1005.66NoYes386
12A:A:?379 A:A:F219 1005.22YesNo398
13A:A:H41 R:R:I472 1007.95YesYes365
14A:A:?379 R:R:I472 1006.11YesYes395
15A:A:?225 A:A:Q227 10.8844.64NoYes099
16A:A:?225 A:A:F208 10.99184.25NoNo096
17A:A:D223 A:A:F208 11.04635.97NoNo096
18A:A:D223 A:A:L45 12.76015.43NoNo098
19A:A:F212 A:A:M221 13.41244.98YesNo098
20B:B:?59 B:B:W332 1007.75YesYes189
21A:A:W281 B:B:W332 75.18727.5YesYes159
22B:B:R314 B:B:W332 10020.99YesYes189
23A:A:?237 B:B:L117 11.44267.41YesYes189
24A:A:W281 B:B:D290 74.61978.93YesYes156
25B:B:D290 B:B:R314 74.61238.34YesYes168
26A:A:R380 R:R:I472 1007.52NoYes075
27A:A:Q384 A:A:R380 1008.18NoNo067
28A:A:Q384 R:R:I468 1004.12NoNo067
29A:A:L388 R:R:I468 1005.71NoNo087
30A:A:L388 A:A:L393 1005.54NoNo089
31A:A:?391 A:A:L393 1009.42YesNo049
32A:A:?391 R:R:R464 10016.54YesYes648
33B:B:?233 B:B:I232 17.92226.11YesYes038
34B:B:F241 B:B:I232 16.30058.79YesYes168
35B:B:F222 B:B:F241 16.032612.86NoYes186
36B:B:F222 B:B:Q220 1008.2NoNo187
37B:B:D258 B:B:Q220 10010.44YesNo177
38B:B:D258 B:B:R22 10015.48YesNo076
39B:B:I18 B:B:R22 70.78126.26YesNo076
40B:B:I18 G:G:A23 1003.25YesNo078
41G:G:?20 G:G:A23 1002.82YesNo068
42G:G:?20 G:G:V16 87.8653.55YesNo067
43B:B:L7 G:G:V16 73.2212.98YesNo087
44B:B:L7 G:G:A12 36.61063.15YesNo085
45B:B:L4 G:G:A12 29.28851.58NoNo045
46B:B:D258 G:G:R27 73.218910.72YesNo178
47B:B:I18 G:G:R27 1005.01YesNo078
48B:B:Q220 G:G:I25 75.65924.12NoNo172
49G:G:I25 G:G:R27 73.21886.26NoNo128
50B:B:L14 G:G:?20 29.28854.95NoYes086
51B:B:?15 B:B:I18 51.25483.41NoYes067
52B:B:?15 B:B:N16 43.93274.1NoYes061
53B:B:E12 B:B:N16 14.644315.77NoYes041
54B:B:L14 G:G:L19 14.64434.15NoNo089
55B:B:N16 B:B:R19 14.644312.05YesNo014
56B:B:Q17 G:G:A23 14.64431.52NoNo048
57B:B:Q259 B:B:R22 39.05317.01NoNo066
58B:B:A26 B:B:Q259 36.61244.55NoNo036
59B:B:?25 B:B:A26 34.17173.37YesNo033
60B:B:?25 B:B:D27 24.40865.81YesNo038
61B:B:D27 G:G:S31 12.20448.83NoNo089
62B:B:?317 B:B:M61 40.81214.54YesYes176
63B:B:?317 B:B:V315 74.11954.79YesNo077
64B:B:?288 B:B:V315 73.97725.2NoNo077
65B:B:?288 B:B:?289 73.835227NoYes177
66B:B:?289 B:B:W297 79.21845.54YesYes178
67B:B:?264 B:B:W297 68.912522.15YesYes058
68B:B:?317 B:B:?59 1007.21YesYes178
69B:B:?289 B:B:D290 1006.6YesYes176
70B:B:R314 B:B:T274 74.033511.64YesNo188
71B:B:?289 B:B:T274 73.89258.6YesNo178
72B:B:?289 B:B:N295 12.678618.7YesYes176
73B:B:?319 B:B:W63 31.00858.94NoYes057
74B:B:L284 B:B:V296 15.52554.47NoNo055
75B:B:I43 B:B:L284 14.23225.71NoNo035
76B:B:F253 B:B:T243 63.68789.08YesYes168
77B:B:?224 B:B:F253 63.68444.25NoYes066
78B:B:?289 B:B:I273 10012.49YesYes176
79B:B:?250 B:B:I273 1006.11YesYes186
80B:B:?250 B:B:R251 1006.5YesYes188
81B:B:H225 B:B:T243 64.282110.95YesYes198
82B:B:?244 B:B:I273 68.3047.47NoYes056
83B:B:?319 B:B:V320 28.54665.2NoNo057
84B:B:S277 B:B:V320 28.40234.85NoNo057
85B:B:E260 B:B:F253 1004.66NoYes066
86B:B:?264 B:B:T263 64.86418.6YesNo051
87B:B:?306 B:B:R304 16.091412.71NoYes045
88B:B:L4 G:G:S8 14.64433NoNo044
89B:B:L7 G:G:R13 21.96642.43YesNo086
90G:G:I9 G:G:R13 14.644310.02NoNo026
91R:R:?623 R:R:R464 1008.27YesYes698
92R:R:?623 R:R:L401 1005.38YesYes698
93R:R:D405 R:R:L401 1006.79YesYes698
94R:R:D405 R:R:S616 1008.83YesNo099
95R:R:M408 R:R:S616 1009.2NoNo089
96R:R:?612 R:R:M408 1008.25YesNo078
97R:R:?612 R:R:F515 10011.85YesYes479
98R:R:?411 R:R:F515 1004.74YesYes479
99R:R:?411 R:R:L412 1009.42YesNo478
100R:R:I366 R:R:L412 1005.71YesNo498
101R:R:I366 R:R:M357 1005.83YesNo497
102R:R:D419 R:R:M357 1009.7YesNo497
103R:R:D419 R:R:I356 1005.6YesNo098
104R:R:I356 R:R:S512 1004.64NoNo089
105R:R:E354 R:R:S512 1004.31YesNo079
106R:R:?353 R:R:E354 1008.51NoYes097
107R:R:?280 R:R:?353 1009.52NoNo099
108R:R:?279 R:R:?280 10025.4NoNo099
109R:R:?279 R:R:F282 1007.83NoYes098
110R:R:F265 R:R:F282 1007.5YesYes1478
111R:R:F265 R:R:L248 1006.09YesNo1479
112R:R:L227 R:R:L248 1004.15YesNo1489
113R:R:L202 R:R:L227 1004.15YesYes078
114R:R:L202 R:R:L204 10011.07YesNo079
115R:R:L181 R:R:L204 1004.15YesNo089
116R:R:I155 R:R:L181 84.29344.28YesYes088
117R:R:I155 R:R:L153 22.36748.56YesNo089
118R:R:L128 R:R:L153 21.12744.15YesNo089
119R:R:L401 R:R:N619 1008.24YesYes689
120R:R:N615 R:R:N619 1005.45NoYes099
121R:R:?581 R:R:N615 10013.23YesNo099
122R:R:?581 R:R:?612 1004.32YesYes497
123R:R:?623 R:R:L457 1005.38YesNo699
124R:R:L457 R:R:N619 1009.61NoYes699
125R:R:?426 R:R:S512 1004.38YesNo099
126R:R:?426 R:R:?427 10028.81YesYes2997
127R:R:?427 R:R:A281 1006.13YesNo078
128R:R:A281 R:R:R262 1004.15NoNo085
129R:R:F282 R:R:R262 10011.76YesNo085
130R:R:I155 R:R:N158 58.69174.25YesYes289
131R:R:?131 R:R:N158 24.0195.88YesYes279
132R:R:?131 R:R:N132 35.43075.88YesYes278
133R:R:N107 R:R:N132 11.18265.45YesYes278
134R:R:?279 R:R:?343 98.726115.87NoNo099
135R:R:?343 R:R:R342 98.32147.81NoNo094
136R:R:E270 R:R:R342 98.119411.63NoNo064
137R:R:E270 R:R:R247 97.91765.82NoNo065
138R:R:R247 R:R:T226 96.51355.17NoNo054
139R:R:S201 R:R:T226 95.71286.4NoNo054
140R:R:E203 R:R:S201 95.51284.31NoNo055
141R:R:?182 R:R:E203 95.312916.75YesNo065
142R:R:?156 R:R:?182 12.423115.86YesYes276
143R:R:?131 R:R:?156 12.066830.16YesYes277
144L:L:?115 R:R:?182 79.02115.62YesYes206
145L:L:?115 M:M:?120 30.0696.19YesYes200
146M:M:?120 M:M:T118 15.61724.74YesNo000
147L:L:V77 M:M:T118 15.40364.76YesNo000
148M:M:?120 M:M:D119 10.89244.36YesNo000
149R:R:N158 R:R:T133 18.26218.77YesYes298
150R:R:I135 R:R:T133 15.87147.6YesYes078
151R:R:I114 R:R:I135 29.99745.89YesYes087
152R:R:?113 R:R:I114 15.85635.55YesYes018
153R:R:?62 R:R:E87 10.014811.86YesNo045
154R:R:I161 R:R:N158 16.19025.66NoYes079
155R:R:I135 R:R:I161 15.79544.42YesNo077
156R:R:I245 R:R:L248 21.43824.28NoNo1489
157R:R:I245 R:R:L242 21.03094.28NoNo089
158R:R:?241 R:R:L242 41.23554.83YesNo079
159R:R:?240 R:R:?241 35.463823.48YesYes1627
160R:R:?240 R:R:R219 33.142623.63YesNo021
161R:R:H192 R:R:R219 30.60949.03YesNo051
162H:H:?2 R:R:H192 23.93168.03YesYes005
163H:H:?2 R:R:Q170 19.068716.62YesYes1503
164R:R:?171 R:R:Q170 15.8486.96NoYes043
165R:R:?171 R:R:F145 15.0144.25NoNo043
166R:R:?143 R:R:F145 14.1816.71YesNo043
167R:R:F265 R:R:P260 30.11427.22YesYes076
168R:R:L237 R:R:P260 22.28498.21NoYes076
169R:R:L237 R:R:L242 21.03385.54NoNo079
170R:R:?180 R:R:L181 1006.61NoYes058
171R:R:?180 R:R:E154 1008.7NoYes057
172R:R:?127 R:R:E154 10014.18YesYes267
173L:L:?111 R:R:?127 51.88674.32YesYes206
174L:L:?115 L:L:H114 48.30648.44YesYes200
175L:L:?111 L:L:H114 25.919222.03YesYes200
176L:L:?112 R:R:?127 43.577418.33YesYes206
177L:L:?112 L:L:H114 21.79157.5YesYes200
178L:L:M71 R:R:N132 22.39357.01YesYes208
179L:L:?111 L:L:?83 75.870517.46YesYes200
180L:L:?83 L:L:?84 60.940823.81YesYes200
181L:L:?52 L:L:?84 1006.35YesYes200
182L:L:?52 L:L:Q51 75.95457.13YesNo000
183L:L:N39 L:L:Q51 56.03325.28YesNo000
184L:L:F41 L:L:N39 21.17037.25YesYes3000
185L:L:?112 L:L:V85 62.18814.35YesYes200
186L:L:?84 L:L:V85 60.94454.79YesYes200
187L:L:F41 R:R:D330 17.435620.3YesNo004
188R:R:?331 R:R:D330 16.19036.6NoNo014
189R:R:?331 R:R:?333 13.69966.55NoYes1711
190R:R:?333 R:R:?336 11.208821.62YesYes1716
191L:L:?108 L:L:?83 13.691520.63YesYes200
192L:L:?108 L:L:?56 11.22889.52YesYes200
193L:L:I49 L:L:N39 17.43554.25YesYes000
194L:L:I49 L:L:N102 41.09254.25YesNo000
195H:H:?4 L:L:N102 29.885623.27NoNo000
196L:L:Q51 M:M:V64 18.6787.16NoNo000
197L:L:I49 M:M:V64 34.86534.61YesNo000
198L:L:?52 L:L:H103 22.413212.39YesYes000
199L:L:H103 M:M:V64 18.67869.69YesNo000
200L:L:F42 L:L:N39 14.94388.46NoYes3000
201L:L:F42 M:M:L65 13.69964.87NoNo000
202H:H:?4 L:L:P48 18.67867.32NoNo000
203L:L:?46 L:L:P48 14.94292.86NoNo000
204L:L:?46 L:L:A47 11.20722.75NoNo000
205L:L:?68 L:L:M71 28.19455.9YesYes200
206L:L:?68 L:L:?69 25.74028.87YesYes000
207L:L:?69 L:L:L65 23.24974.13YesNo000
208L:L:L65 M:M:E39 22.41953.98NoNo000
209M:M:?46 M:M:E39 19.928711.35YesNo000
210M:M:?46 M:M:I47 14.94739.17YesNo000
211M:M:I47 M:M:P90 13.28676.77NoNo000
212B:B:M61 B:B:W63 40.37568.14YesYes167
213A:A:L45 A:A:M221 12.81567.07NoNo088
214B:B:?233 B:B:S277 28.25834.82YesNo035
215B:B:?41 B:B:I43 12.93934.98NoNo013
216B:B:?306 B:B:V296 14.94057.79NoNo045
217B:B:?224 B:B:R251 64.829812.71NoYes068
218B:B:?244 B:B:H225 67.14975.61NoYes059
219B:B:E260 B:B:R251 64.253120.93NoYes068
220B:B:E260 B:B:T263 64.28659.88NoNo061
221B:B:F222 B:B:F253 10015NoYes186
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:?58 R:R:A57 9.19 0 Yes No 5 4 1 2
R:R:?58 R:R:L59 8.08 0 Yes No 5 7 1 2
R:R:?58 R:R:Q82 16.83 0 Yes Yes 5 6 1 1
M:M:H126 R:R:?58 16.26 0 No Yes 0 5 0 1
R:R:Q82 R:R:S81 7.22 0 Yes No 6 6 1 2
R:R:Q106 R:R:S81 4.33 0 No No 7 6 2 2
R:R:N107 R:R:Q82 11.88 2 Yes Yes 7 6 1 1
M:M:?124 R:R:Q82 7.94 0 Yes Yes 0 6 0 1
L:L:T110 R:R:E102 8.47 2 No No 0 7 0 1
L:L:?112 R:R:E102 10.31 2 Yes No 0 7 0 1
R:R:N107 R:R:Q106 18.49 2 Yes No 7 7 1 2
R:R:N107 R:R:N132 5.45 2 Yes Yes 7 8 1 1
L:L:M71 R:R:N107 8.41 2 Yes Yes 0 7 0 1
R:R:?126 R:R:?127 12.85 0 Yes Yes 5 6 2 1
R:R:?126 R:R:E148 6.32 0 Yes No 5 5 2 1
R:R:?127 R:R:S129 10.22 2 Yes No 6 7 1 2
R:R:?127 R:R:I152 5.55 2 Yes Yes 6 4 1 1
R:R:?127 R:R:E154 14.18 2 Yes Yes 6 7 1 1
L:L:?111 R:R:?127 4.32 2 Yes Yes 0 6 0 1
L:L:?112 R:R:?127 18.33 2 Yes Yes 0 6 0 1
R:R:E154 R:R:S129 10.06 2 Yes No 7 7 1 2
R:R:?131 R:R:N132 5.88 2 Yes Yes 7 8 2 1
R:R:?131 R:R:?156 30.16 2 Yes Yes 7 7 2 2
R:R:?131 R:R:D157 5.81 2 Yes No 7 6 2 1
L:L:M71 R:R:N132 7.01 2 Yes Yes 0 8 0 1
L:L:L72 R:R:N132 4.12 0 No Yes 0 8 0 1
L:L:V73 R:R:N132 4.43 0 No Yes 0 8 0 1
R:R:?134 R:R:H160 6.73 0 Yes No 5 3 2 1
L:L:?89 R:R:E148 9.02 13 Yes No 0 5 0 1
L:L:R91 R:R:S149 7.91 13 No No 0 3 0 1
L:L:E101 R:R:S149 8.62 13 No No 0 3 0 1
M:M:Q66 R:R:N150 11.88 0 No No 0 5 0 1
R:R:I152 R:R:T178 4.56 2 Yes No 4 6 1 2
L:L:?112 R:R:I152 4.16 2 Yes Yes 0 4 0 1
L:L:?113 R:R:I152 6.94 2 Yes Yes 0 4 0 1
R:R:?156 R:R:E154 4.26 2 Yes Yes 7 7 2 1
R:R:?180 R:R:E154 8.7 0 No Yes 5 7 2 1
L:L:?115 R:R:E154 7.11 2 Yes Yes 0 7 0 1
R:R:?156 R:R:D157 17.44 2 Yes No 7 6 2 1
R:R:?156 R:R:?182 15.86 2 Yes Yes 7 6 2 1
R:R:?156 R:R:N184 14.7 2 Yes Yes 7 9 2 2
M:M:R115 R:R:D157 10.72 2 Yes No 0 6 0 1
L:L:L72 R:R:H160 7.71 0 No No 0 3 0 1
R:R:?180 R:R:?182 16.87 0 No Yes 5 6 2 1
R:R:?182 R:R:?183 15.26 2 Yes Yes 6 7 1 1
R:R:?182 R:R:N184 10.68 2 Yes Yes 6 9 1 2
R:R:?182 R:R:E203 16.75 2 Yes No 6 5 1 2
R:R:?182 R:R:?205 8.03 2 Yes No 6 7 1 2
L:L:?115 R:R:?182 5.62 2 Yes Yes 0 6 0 1
M:M:R115 R:R:?182 8.27 2 Yes Yes 0 6 0 1
R:R:?183 R:R:N184 8.38 2 Yes Yes 7 9 1 2
R:R:?183 R:R:N207 5.99 2 Yes No 7 9 1 2
M:M:R115 R:R:?183 5.3 2 Yes Yes 0 7 0 1
R:R:N184 R:R:N207 5.45 2 Yes No 9 9 2 2
R:R:?205 R:R:E206 9.49 0 No No 7 4 2 1
M:M:R115 R:R:E206 15.12 2 Yes No 0 4 0 1
R:R:R247 R:R:T226 5.17 0 No No 5 4 1 2
R:R:E270 R:R:R247 5.82 0 No No 6 5 2 1
M:M:P70 R:R:R247 7.21 0 No No 0 5 0 1
L:L:F41 R:R:?328 4.25 30 Yes No 0 1 0 1
R:R:?331 R:R:D330 6.6 17 No No 1 4 2 1
L:L:F41 R:R:D330 20.3 30 Yes No 0 4 0 1
H:H:?4 L:L:P48 7.32 0 No No 0 0 1 0
H:H:?4 L:L:L50 7.41 0 No No 0 0 1 0
H:H:?3 L:L:N76 25.72 0 No No 0 0 1 0
H:H:?4 L:L:N102 23.27 0 No No 0 0 1 0
H:H:?5 M:M:N33 26.95 0 No No 0 0 1 0
H:H:?3 M:M:A103 4.22 0 No No 0 0 1 0
R:R:?126 R:R:N150 4.1 0 Yes No 5 5 2 1
R:R:?77 R:R:E102 3.95 0 No No 5 7 2 1
R:R:?328 R:R:W329 2.98 0 No No 1 3 1 2
L:L:H107 R:R:R53 2.26 0 No No 0 2 0 1
H:H:?5 M:M:N50 1.22 0 No No 0 0 1 0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
50.00Single7T9ITSH7T9I-TSH-TSH-Gs/&β;1/&γ;2
33.33Single7UTZTR14027UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
33.33Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
25.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
25.00Single6D35Cholesterol6D35-SMO-Cholesterol
25.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
25.00Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
25.00Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
25.00Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
25.00Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
25.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
25.00Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
25.00Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-PubChem 7023848
25.00Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
25.00Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626-Phospholipid
25.00Single7DD5Ca37DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
25.00Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
25.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
25.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
25.00Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
25.00Single7DTTCa7DTT-CaS-Ca-Ca
25.00Single7DTTCa7DTT-CaS-Ca-Ca
25.00Single7DTUTryptophan7DTU-CaS-Tryptophan
25.00Single7DTUTryptophan7DTU-CaS-Tryptophan
25.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
25.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
25.00Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
25.00Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
25.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
25.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
25.00Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
25.00Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
25.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
25.00Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
25.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
25.00Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2
25.00Single7EB2Baclofen7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
25.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
25.00Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
25.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
25.00Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
25.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
25.00Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
25.00Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Single7FIIhCG7FII-LH-hCG-6fuf
25.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
25.00Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
25.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
25.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
25.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
25.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
25.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
25.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
25.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
25.00Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
25.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
25.00Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
25.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
25.00Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
25.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
25.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
25.00Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
25.00Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
25.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
25.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
25.00Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
25.00Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
25.00Single7T9NM22 Fab7T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
25.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
25.00Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
25.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
25.00Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
25.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
25.00Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
25.00Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
25.00Single7XW7K1-707XW7-TSH-K1-70
25.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
25.00Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
25.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
25.00Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
25.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
25.00Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
25.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
25.00Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
25.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
25.00Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
25.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
25.00Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
25.00Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-J9R
25.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
25.00Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
25.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
25.00Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
25.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
25.00Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
25.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
25.00Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
25.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
25.00Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
25.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
25.00Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
25.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
25.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
25.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
25.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
25.00Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
25.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
25.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
25.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
25.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
25.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
25.00Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
25.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
25.00Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
25.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
25.00Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
25.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
25.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
25.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
25.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
25.00Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
25.00Consensusclass-c_offOrthosteric Ligandgabab_off mglu_off
25.00Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
25.00Consensusclass-c_onOrthosteric Ligandgabab_on mglu_on
25.00Consensusfsh_on_alloOrthosteric Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
25.00Consensusgabab_offOrthosteric Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
25.00Consensusgabab_onOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
25.00Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
25.00Consensusgi_class-cOrthosteric Ligandgi_mglu gi_gaba
25.00Consensusgi_gabaOrthosteric Ligand7EB2-GABAB1, GABAB2-Baclofen-rac-BHFF-Gi1/&β;1/&γ;2
25.00Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
25.00Consensusgi_mgluOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
25.00Consensusgphr_onOrthosteric Ligandlh_on tsh_on
25.00Consensusgs_gphrOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2 7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
25.00Consensusgs_proteinOrthosteric Ligandgs_gphr
25.00Consensuslh_onOrthosteric Ligand7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
25.00Consensuslh_on_alloOrthosteric Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
25.00Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
25.00Consensusmglu2_offOrthosteric Ligand7MTQ-mGlu2; mGlu2-LY341495
25.00Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
25.00Consensusmglu2_onOrthosteric Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
25.00Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
25.00Consensusmglu3_offOrthosteric Ligand7WI8-mGlu3; mGlu3-LY341495 7WIH-mGlu3; mGlu3-LY2794193
25.00Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
25.00Consensusmglu4_onOrthosteric Ligand7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/&β;1/&γ;2 8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
25.00Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
25.00Consensusmglu5_offOrthosteric Ligand7FD9-mGlu5; mGlu5-LY341495
25.00Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
25.00Consensusmglu_offOrthosteric Ligandmglu2_off mglu3_off mglu5_off
25.00Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
25.00Consensusmglu_onOrthosteric Ligandmglu2_on mglu4_on
25.00Consensussmo_off_alloOther Ligand6D32-SMO-Cyclopamine-Cyclopamine
25.00Consensustsh_onOrthosteric Ligand7T9I-TSH-TSH-Gs/&β;1/&γ;2
25.00Consensustsh_on_alloOrthosteric Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
20.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
20.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
20.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
20.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
20.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
20.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
20.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
20.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
20.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
20.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
16.67Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
16.67Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
16.67Single8HS2Fab0468HS2-GPR20-Fab046
14.29Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
14.29Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
12.50Single5L7DCholesterol5L7D-SMO-Cholesterol
12.50Single8HSCFab0468HSC-GPR20-Fab046-Gi1/&β;1/&γ;2
12.50Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
11.11Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
11.11Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/&β;1/&γ;2
10.00Single4XNWMRS25004XNW-P2Y1-MRS2500
10.00Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
10.00Single6LI0GTPL98046LI0-GPR52-GTPL9804
10.00Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
10.00Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
10.00Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
9.09Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
9.09Single4O9RCyclopamine4O9R-SMO-Cyclopamine
9.09Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
9.09Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
9.09Consensusgo_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
9.09Consensusgo_proteinOrthosteric Ligandgo_chemokine
9.09Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
8.33Single4BWBNeurotensin4BWB-NTS1-Neurotensin
8.33Single4QINSAG1.54QIN-SMO-SAG1.5
8.33Single5U09Taranabant5U09-CB1-Taranabant
8.33Single6FJ3PTH6FJ3-PTH1-PTH
8.33Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
8.33Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
8.33Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
8.33Single6WWZCCL206WWZ-CCR6-CCL20-Go/&β;1/&γ;2
8.33Single7BR3Elagolix7BR3-GnRH1-Elagolix
8.33Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
8.33Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
8.33Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
8.33Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
8.33Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
8.33Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
8.33Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/&β;1/&γ;2
8.33Consensusclass-f_offOrthosteric Ligandsmo_off
8.33Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
8.33Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
8.33Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
7.69Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
7.69Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
7.69Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
7.69Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
7.69Single7VV6C48/807VV6-MRGPRX2-C48/80
7.69Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
7.69Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
7.69Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.69Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
7.69Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
7.69Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
7.69Consensusgi_class-fOrthosteric Ligandgi_frizzled
7.69Consensusgi_frizzledOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
7.69Consensusgnrh_offOrthosteric Ligandgnrh1_off
7.69Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
7.69Consensuss1p_offOrthosteric Ligands1p1_off
7.14Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
7.14Single5T04Neurotensin5T04-NTS1-Neurotensin
7.14Single5TGZAM65385TGZ-CB1-AM6538
7.14Single6D27CAY104716D27-DP2-CAY10471
7.14Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
7.14Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
7.14Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
7.14Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
7.14Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
7.14Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
7.14Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
7.14Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
7.14Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
7.14Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
7.14Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
7.14Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
7.14Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
7.14Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
7.14Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
7.14Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
7.14Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
6.67Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
6.67Single5C1MBU725C1M-μ-BU72
6.67Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
6.67Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
6.67Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
6.67Single7C4SS1P7C4S-S1P3-S1P
6.67Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
6.67Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
6.67Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
6.67Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
6.67Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
6.67Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
6.67Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
6.67Single7YXAONO-54306087YXA-S1P5-ONO-5430608
6.67Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
6.67Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
6.25Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
6.25Single4BV0Neurotensin4BV0-NTS1-Neurotensin
6.25Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
6.25Single5V56TC1145V56-SMO-TC114
6.25Single5V57TC1145V57-SMO-TC114
6.25Single6OS1TRV0266OS1-AT1-TRV026
6.25Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
6.25Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
6.25Single7F1TMIP-1a7F1T-CCR5-MIP-1a
6.25Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
6.25Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
6.25Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
6.25Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
6.25Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
6.25Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
6.25Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
6.25Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
6.25Single8E0GBU728E0G-μ-BU72
6.25Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
6.25Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
6.25Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
6.25Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
6.25Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
6.25Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
6.25Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
6.25Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
6.25Consensuslpa_offOrthosteric Ligandlpa1_off
6.25Consensuslpa_onOrthosteric Ligandlpa1_on
6.25Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
6.25Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
5.88Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
5.88Single4XEENeurotensin4XEE-NTS1-Neurotensin
5.88Single4XESNeurotensin4XES-NTS1-Neurotensin
5.88Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
5.88Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
5.88Single6OS2TRV0266OS2-AT1-TRV026
5.88Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
5.88Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
5.88Single6YVRNTS8-136YVR-NTS1-NTS8-13
5.88Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
5.88Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
5.88Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
5.88Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
5.88Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
5.88Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.88Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
5.88Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.88Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
5.88Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
5.88Consensuschemokine_offOrthosteric Ligandcxcr_off
5.88Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
5.88Consensuscxcr_offOrthosteric Ligandcxcr4_off
5.88Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
5.88Consensusdp_offOrthosteric Liganddp2_off
5.88Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
5.88Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
5.88Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
5.88Consensusnts_onOrthosteric Ligandnts1_on
5.88Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
5.88Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
5.56Single4BUONeurotensin4BUO-NTS1-Neurotensin
5.56Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
5.56Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
5.56Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
5.56Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
5.56Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
5.56Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
5.56Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
5.56Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.56Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
5.56Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
5.56Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
5.56Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
5.56Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
5.56Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
5.56Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
5.56Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
5.26Single6KNMJN241-96KNM-Apelin-JN241-9
5.26Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
5.26Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
5.26Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
5.26Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
5.26Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
5.26Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
5.26Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
5.26Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
5.26Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
5.26Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
5.26Consensuslpl_offOrthosteric Ligands1p_off lpa_off
5.26Consensuslpl_onOrthosteric Ligands1p_on lpa_on
5.26Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
5.26Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
5.00Single4XT1Fractalkine4XT1-US28-Fractalkine
5.00Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
5.00Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
5.00Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
5.00Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
5.00Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
5.00Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
5.00Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
5.00Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/&β;1/&γ;2
5.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
5.00Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
5.00Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
5.00Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
5.00Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
5.00Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
5.00Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
5.00Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
4.76Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
4.76Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
4.76Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
4.76Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
4.76Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
4.76Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
4.76Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
4.76Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
4.76Single7SK5CXCL127SK5-ACKR3-CXCL12
4.76Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
4.76Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
4.76Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.76Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
4.76Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
4.76Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
4.55Single3OE0CVX153OE0-CXCR4-CVX15
4.55Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
4.55Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
4.55Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
4.55Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
4.55Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
4.55Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
4.55Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
4.55Consensusangiotensin_onOrthosteric Ligandat1_on
4.55Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
4.55Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
4.55Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
4.55Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
4.55Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
4.55Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.55Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
4.55Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
4.55Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
4.35Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
4.35Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
4.35Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
4.35Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
4.35Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
4.35Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
4.35Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.35Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
4.35Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
4.35Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
4.35Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.35Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
4.35Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
4.35Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
4.35Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
4.35Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
4.35Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
4.35Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
4.35Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
4.35Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
4.35Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
4.35Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
4.35Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
4.35Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.17Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.17Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
4.17Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
4.17Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
4.17Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
4.17Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
4.17Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
4.17Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
4.17Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
4.17Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
4.17Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
4.17Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.17Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
4.17Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
4.17Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
4.17Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
4.17Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
4.17Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
4.17Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.17Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
4.00Single4XT3Fractalkine4XT3-US28-Fractalkine
4.00Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
4.00Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.00Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
4.00Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
4.00Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
4.00Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
4.00Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.00Single7SK3CXCL127SK3-ACKR3-CXCL12
4.00Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
4.00Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
4.00Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
4.00Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
4.00Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
4.00Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
4.00Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
4.00Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
4.00Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
4.00Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
4.00Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
4.00Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
4.00Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
4.00Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
3.85Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
3.85Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
3.85Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
3.85Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
3.85Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
3.85Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
3.85Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
3.85Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
3.85Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
3.85Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
3.85Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
3.85Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
3.85Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
3.85Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
3.85Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
3.85Consensusgo_class-b1Orthosteric Ligandgo_crf
3.85Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
3.85Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
3.70Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
3.70Single6LMLGlucagon6LML-Glucagon-Glucagon
3.70Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
3.70Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
3.70Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
3.70Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
3.70Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
3.70Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
3.70Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
3.70Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
3.70Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
3.70Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
3.70Single8IY6Endothelin-18IY6-ETB-Endothelin-1
3.70Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
3.70Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
3.70Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
3.70Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
3.70Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
3.70Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
3.70Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
3.70Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
3.70Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
3.70Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
3.57Single5GLHEndothelin-15GLH-ETB-Endothelin-1
3.57Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
3.57Single6IGKEndothelin-36IGK-ETB-Endothelin-3
3.57Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
3.57Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.57Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
3.57Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
3.57Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
3.57Single7TYLAmylin7TYL-CT-Amylin-Gs/&β;1/&γ;2
3.57Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
3.57Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/&β;1/&γ;2; RAMP2
3.57Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
3.57Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
3.57Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
3.45Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
3.45Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
3.45Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
3.45Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.45Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
3.45Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
3.45Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
3.45Consensusglp_onOrthosteric Ligandglp1_on glp2_on
3.45Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
3.33Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
3.33Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
3.33Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
3.33Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.33Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.33Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
3.33Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
3.33Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
3.33Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
3.33Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
3.23Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
3.23Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
3.23Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
3.23Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
3.23Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
3.23Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.23Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
3.23Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.23Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
3.23Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
3.23Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
3.23Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
3.23Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
3.12Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
3.12Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
3.12Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
3.12Consensuspth_onOrthosteric Ligandpth1_on pth2_on
3.03Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
3.03Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
2.94Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
2.94Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
2.94Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
2.86Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
2.86Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
2.86Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
2.78Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
2.78Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
2.78Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.70Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
2.70Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
2.63Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

PDB Summary
PDB 7FIG
Class A
SubFamily Protein
Type Glycoprotein hormone
SubType LH
Species Homo sapiens
Ligand hCG
Other Ligand(s) -
Protein Partners chim(NtGi1L-Gs)/Beta1/Gamma2
PDB Resolution 3.9
Date 2021-09-29
D.O.I. 10.1038/s41586-021-03924-2
Net Summary
Imin 4.11
Number of Linked Nodes 1365
Number of Links 1738
Number of Hubs 294
Number of Links mediated by Hubs 1119
Number of Communities 34
Number of Nodes involved in Communities 392
Number of Links involved in Communities 594
Path Summary
Number Of Nodes in MetaPath 222
Number Of Links MetaPath 221
Number of Shortest Paths 69761575
Length Of Smallest Path 3
Average Path Length 128
Length of Longest Path 82
Minimum Path Strength 1.225
Average Path Strength 16.0014
Maximum Path Strength 34.055
Minimum Path Correlation 0.72
Average Path Correlation 1
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.12766
Average % Of Corr. Nodes 89.0392
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 66.2512
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .
CodeCMS
PDB ResiduesA:A:?10 A:A:?237 A:A:?359 A:A:?365 A:A:?379 B:B:?25 B:B:?103 B:B:?114 B:B:?121 B:B:?148 B:B:?149 B:B:?166 B:B:?204 B:B:?218 B:B:?233 B:B:?250 B:B:?271 B:B:?294 B:B:?317 G:G:?41 R:R:?131 R:R:?156 R:R:?279 R:R:?280 R:R:?336 R:R:?343 R:R:?353 R:R:?399 R:R:?407 R:R:?439 R:R:?514 R:R:?543 R:R:?545 R:R:?581 R:R:?617 R:R:?643 R:R:?644 L:L:?31 L:L:?34 L:L:?52 L:L:?55 L:L:?56 L:L:?83 L:L:?84 L:L:?106 L:L:?108 L:L:?111 M:M:?29 M:M:?43 M:M:?46 M:M:?54 M:M:?58 M:M:?77 M:M:?92 M:M:?108 M:M:?110 M:M:?113 M:M:?120 M:M:?130
Environment DetailsOpen EMBL-EBI Page
CodeCMS
NameCARBAMOYL SARCOSINE
Synonyms
Identifier2-(aminocarbonyl-methyl-amino)ethanoic acid
FormulaC4 H8 N2 O3
Molecular Weight132.118
SMILESCN(CC(=O)O)C(=O)N
PubChem439375
Formal Charge0
Total Atoms17
Total Chiral Atoms0
Total Bonds16
Total Aromatic Bonds0

CodeLMS
PDB ResiduesA:A:?17 A:A:?24 A:A:?28 A:A:?32 A:A:?34 A:A:?53 A:A:?58 A:A:?211 A:A:?216 A:A:?233 A:A:?274 A:A:?293 A:A:?300 A:A:?305 A:A:?307 A:A:?338 B:B:?15 B:B:?23 B:B:?57 B:B:?78 B:B:?89 B:B:?127 B:B:?209 B:B:?280 B:B:?301 B:B:?337 G:G:?14 G:G:?20 G:G:?29 G:G:?32 G:G:?46 R:R:?62 R:R:?77 R:R:?109 R:R:?126 R:R:?137 R:R:?143 R:R:?180 R:R:?205 R:R:?212 R:R:?225 R:R:?233 R:R:?257 R:R:?258 R:R:?339 R:R:?390 R:R:?423 R:R:?477 R:R:?510 R:R:?548 R:R:?563 R:R:?566 R:R:?569 R:R:?570 R:R:?595 R:R:?605 R:R:?628 R:R:?640 L:L:?68 L:L:?69 L:L:?75 L:L:?87 L:L:?99 L:L:?115 M:M:?22 M:M:?40 M:M:?124
Environment DetailsOpen EMBL-EBI Page
CodeLMS
Name[(2r,3s,4r,5r)-5-(6-Amino-9h-Purin-9-Yl)-3,4-Dihydroxytetrahydro-2-Furanyl]Methyl Sulfamate
Synonyms[(2r,3s,4r,5r)-5-(6-Amino-9h-Purin-9-Yl)-3,4-Dihydroxytetrahydro-2-Furanyl]Methyl Sulfamate
Identifier[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methyl sulfamate
FormulaC10 H14 N6 O6 S
Molecular Weight346.32
SMILESc1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)COS(=O)(=O)N)O)O)N
PubChem97576
Formal Charge0
Total Atoms37
Total Chiral Atoms4
Total Bonds39
Total Aromatic Bonds10

CodeTMR
PDB ResiduesA:A:?37 A:A:?63 A:A:?253 A:A:?311 A:A:?318 A:A:?339 A:A:?358 A:A:?360 A:A:?391 B:B:?59 B:B:?85 B:B:?105 B:B:?111 B:B:?124 B:B:?145 B:B:?264 B:B:?289 G:G:?40 R:R:?58 R:R:?113 R:R:?127 R:R:?182 R:R:?240 R:R:?254 R:R:?275 R:R:?331 R:R:?333 R:R:?359 R:R:?389 R:R:?411 R:R:?426 R:R:?427 R:R:?455 R:R:?470 R:R:?508 R:R:?527 R:R:?546 R:R:?550 R:R:?612 R:R:?623 L:L:?61 L:L:?89 L:L:?112 L:L:?113 M:M:?57 M:M:?79 M:M:?102
Environment DetailsOpen EMBL-EBI Page
CodeTMR
Name2,6-dideoxy-4-S-methyl-4-thio-beta-D-ribo-hexopyranose
Synonyms2,6-DIDEOXY-4-THIOMETHYL-BETA-D-RIBOHEXOPYRANOSIDE; 2,6-dideoxy-4-S-methyl-4-thio-beta-D-ribo-hexose; 2,6-dideoxy-4-S-methyl-4-thio-D-ribo-hexose; 2,6-dideoxy-4-S-methyl-4-thio-ribo-hexose
Identifier(2R,4S,5S,6R)-6-methyl-5-methylsulfanyl-oxane-2,4-diol
FormulaC7 H14 O3 S
Molecular Weight178.249
SMILESC[C@@H]1[C@H]([C@H](C[C@@H](O1)O)O)SC
PubChem447846
Formal Charge0
Total Atoms25
Total Chiral Atoms4
Total Bonds25
Total Aromatic Bonds0

CodeGLM
PDB ResiduesA:A:?47 A:A:?52 A:A:?225 A:A:?304 A:A:?329 A:A:?353 A:A:?355 B:B:?41 B:B:?53 B:B:?64 B:B:?77 B:B:?109 B:B:?115 B:B:?116 B:B:?131 B:B:?141 B:B:?144 B:B:?162 B:B:?174 B:B:?182 B:B:?185 B:B:?202 B:B:?216 B:B:?224 B:B:?238 B:B:?244 B:B:?272 B:B:?282 B:B:?288 B:B:?306 B:B:?310 B:B:?319 B:B:?324 B:B:?330 R:R:?71 R:R:?117 R:R:?134 R:R:?166 R:R:?171 R:R:?183 R:R:?185 R:R:?196 R:R:?216 R:R:?220 R:R:?223 R:R:?241 R:R:?328 R:R:?334 R:R:?358 R:R:?376 R:R:?409 R:R:?424 R:R:?436 R:R:?438 R:R:?443 R:R:?489 R:R:?490 R:R:?504 R:R:?642 L:L:?46 L:L:?54 L:L:?96 L:L:?97 M:M:?42 M:M:?56 M:M:?67 M:M:?91 M:M:?95 M:M:?121 M:M:?122
Environment DetailsOpen EMBL-EBI Page
CodeGLM
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds

CodeNAG
PDB ResiduesH:H:?1 H:H:?2 H:H:?3 H:H:?4 H:H:?5
Environment DetailsOpen EMBL-EBI Page
CodeNAG
NameN-Acetylglucosamine
SynonymsN-Acetyl-D-glucosamine
IdentifierN-[(2R,3R,4R,5S,6R)-6-(hydroxymethyl)-2,4,5-tris(oxidanyl)oxan-3-yl]ethanamide
FormulaC8 H15 N O6
Molecular Weight221.208
SMILESCC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1O)CO)O)O
PubChem24139
Formal Charge0
Total Atoms30
Total Chiral Atoms5
Total Bonds30
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP04896
Sequence
>7FIG_Chain_A
?TLSAED?A AVERS?MIE ?QLQ?D?QV ?RATHRLLL L?ADNS??S 
TIV?QMRI? HVNIFET?F QVD?VNFHM FDV?AQRDE RR?WIQ?FN 
DVTAIIFVV DSSD?NRLQ EALNDF?SI WNNRWLRTI SVILFLN?Q 
DLLAE?VLA ??S?IED?F PEFAR?TTP EDATPEP?E DPRVTRA?? 
FIRDEFLRI STAS?D?RH ???PHFT?S VDTENARRI FND?RDIIQ 
RMHLRQ?EL L


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP54311
Sequence
>7FIG_Chain_B
ELDQLRQEA EQL?NQIRD AR?A?ADAT LSQITNNID PV?RIQMRT 
RRTLR?HLA ?I?AMHW?T DSRLLVSAS QD??LIIWD S?TTN?VHA 
IPLRSSWVM T?A?APS?N ?VA???LDN I?SI?NL?T RE?NVRVSR 
ELA?HT??L S??RFLDDN QIVTSS?DT T?ALWDIET ?QQTTTFT? 
HT?DVMSLS LAPDTRLFV S?A?DASA? LWDVRE?M? RQTFT?HES 
DINAI?FFP N?NAFAT?S DDAT?RLFD LRADQELMT ?SHDNII?? 
ITSVSFS?S ?RLLLA??D DFN?NVWDA L?ADRA?VL A?HDNRVS? 
L?VTDD?MA VAT?SWDSF L?IWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP63212
Sequence
>7FIG_Chain_G
TASIAQAR? LVEQL?MEA NIDRI?VS? AAADLMA?? EAHA?EDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP22888
Sequence
>7FIG_Chain_R
TRLSLA?LP V?VIPSQAF R?LNEVI?I EISQIDSLE RIEANAFDN 
LLNLSEILI QNT?NLR?I EP?AFINLP RL??LSI?N T?IR?FPDV 
T?VFSSESN FILEI?DNL HITTIP?NA FQ?MNNESV TL?L??N?F 
EEVQSHAFN ?TTLTSLEL ?ENVHLE?M HN?AFR?AT ?P?TLDISS 
T?LQALPS? ?LESIQRLI ATSS?SL?? LPSRETFVN LLEATLT?P 
IH??AFRNL P?WD?E??F ?LP?TPR?A PEPDAFNP? EDIM??DFL 
RVLIWLINI LAIM?NMTV LFVLLTSR? ?LTVPRFLM ?NLSFADF? 
M?L?LLLIA SVDSQT??Q ??NHAIDWQ T?S??STA? FFTVFASEL 
SV?TLTVIT LERWHTIT? AIHLDQ?LR LRHAILIML ??WLFSSLI 
AMLPLV?VS N?M?VSI?F PMDVETTLS QV?ILTILI LNVVAFFII 
?A??I?I?F AVRNPELMA TN?DT?IA? ?MAILIFTD FT?MAPISF 
FAISAAF?V PLITVTNS? VLLVLF?PI NS?ANPFL? AIFT?TFQR 
DFFLLLS?F ???


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  



This network is also present in following consensuses:
IdComponents
lh_on7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2
gs_gphr7T9I-TSH-TSH-Gs/&β;1/&γ;2
7FIG-LH-hCG-chim(NtGi1L-Gs)/&β;1/&γ;2

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
5OLHANucleotideAdenosineA2AHomo sapiensVipadenantNa-2.62018-01-1710.1038/s41598-017-18570-w
5GLHAPeptideEndothelinETBHomo sapiensEndothelin-1--2.82016-09-0710.1038/nature19319
7FIGAProteinGlycoprotein hormoneLHHomo sapienshCG-chim(NtGi1L-Gs)/&β;1/&γ;23.92021-09-2910.1038/s41586-021-03924-2
7FIHAProteinGlycoprotein hormoneLHHomo sapienshCGOrg43553chim(NtGi1-Gs)/&β;1/&γ;23.22021-09-2910.1038/s41586-021-03924-2
7FIIAProteinGlycoprotein hormoneLHHomo sapienshCG-6fuf4.32021-09-2910.1038/s41586-021-03924-2
7FIJAProteinGlycoprotein hormoneLHHomo sapiens---3.82021-09-2910.1038/s41586-021-03924-2
6ZFZAAmineAcetylcholine (muscarinic)M1Homo sapiens77-LH-28-1--2.172021-10-0610.1016/j.cell.2021.11.001




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7FIG.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.