psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	Lig	Lig	286.38	Yes	Yes	1	0	0
2	7x31	Lig	12.19	No	Yes	1	3	0
3	7x34	Lig	11.07	No	Yes	0	4	0
4	7x35	Lig	6.18	No	Yes	1	3	0
5	1x28	Lig	18.32	No	Yes	1	2	0
6	2x63	Lig	20.63	No	Yes	1	5	0
7	2x64	Lig	8.69	No	Yes	1	4	0
8	2x67	Lig	7.17	No	Yes	0	3	0
9	1x24	Lig	4.38	No	Yes	1	3	0
10	Lig	NT.Q25	15.56	Yes	No	0	0	3
11	Lig	NT.P23	14.15	Yes	No	0	0	2
12	7x24	Lig	6.76	No	Yes	1	8	0
13	Lig	NT.A21	5.04	Yes	No	0	0	2
14	Lig	NT.Y18	33.68	Yes	No	0	0	7
15	Lig	NT.D20	18.24	Yes	No	0	0	3
16	Lig	NT.D17	7.83	Yes	No	0	0	8
17	E2.F178	Lig	17.21	No	Yes	1	1	0
18	E2.Q175	Lig	23.84	No	Yes	1	2	0
19	E2.E177	Lig	17.49	No	Yes	1	1	0
20	E2.H186	Lig	14.9	Yes	Yes	1	4	0
21	E2.H189	Lig	20.83	No	Yes	1	4	0
22	E2x51	Lig	6.13	No	Yes	1	4	0
23	E2.F187	Lig	6.61	Yes	Yes	1	5	0
24	5x32	Lig	9.57	No	Yes	0	2	0
25	5x36	Lig	4.59	No	Yes	1	4	0
26	5x33	Lig	6.51	No	Yes	1	1	0
27	6x61	Lig	5.78	No	Yes	1	2	0
28	6x62	Lig	5.89	No	Yes	1	3	0
29	Lig	NT.T22	6.47	Yes	No	0	0	5
30	E2.E190	Lig	4.31	No	Yes	1	4	0
31	7x24	NT.C24	7.28	No	No	0	8	9
32	1x24	7x28	7.43	No	No	0	3	2
33	1x24	7x31	4.15	No	No	1	3	3
34	1x25	1x28	3.92	No	No	0	1	2
35	1x27	7x28	8.14	No	No	0	4	2
36	1x27	7x32	3.98	No	No	0	4	2
37	1x30	1x34	12.18	No	No	0	6	6
38	1x30	7x32	4.87	No	No	0	6	2
39	1x35	1x39	8.21	No	Yes	0	5	7
40	1x35	7x35	7.99	No	No	0	5	3
41	1x36	1x37	5.84	No	No	0	5	5
42	1x36	2x65	6.57	No	No	0	5	3
43	1x39	2x57	10.55	Yes	Yes	0	7	7
44	1x39	2x61	4.84	Yes	No	0	7	7
45	1x39	7x39	3.79	Yes	No	0	7	5
46	1x43	1x47	8.53	No	No	0	5	6
47	1x43	2x58	7.22	No	No	0	5	8
48	1x45	7x47	4.91	No	No	0	6	8
49	1x46	7x47	3.92	No	No	0	8	8
50	1x47	1x51	5.71	No	No	0	6	4
51	1x50	2x50	10.77	No	Yes	0	9	9
52	1x50	7x50	9.77	No	No	0	9	9
53	1x52	8x54	4.15	No	No	0	6	5
54	1x54	2x44	4.47	No	No	0	7	6
55	1x56	8x50	10.49	No	No	0	7	8
56	1x57	1x60	9.38	No	Yes	0	7	4
57	1x57	2x43	6.92	No	No	0	7	8
58	1x59	8x53	20.29	No	No	5	4	4
59	1x59	8x57	9.32	No	No	5	4	5
60	1x59	8x60	9.35	No	Yes	5	4	5
61	1x60	I1x50	4.69	Yes	No	0	4	7
62	1x60	2x40	10.17	Yes	No	0	4	8
63	1x60	8x53	9.93	Yes	No	0	4	4
64	2x37	2x39	5.85	No	No	3	7	8
65	2x37	2x40	4.47	No	No	0	7	8
66	2x37	I2x57	6.03	No	Yes	3	7	7
67	2x38	2x42	11.97	No	Yes	3	7	7
68	2x38	3x49	8.32	No	Yes	3	7	8
69	2x38	I2x57	4.96	No	Yes	3	7	7
70	2x39	3x49	10.12	No	Yes	3	8	8
71	2x39	I2x57	5.17	No	Yes	3	8	7
72	2x42	3x45	17.58	Yes	No	0	7	7
73	2x42	3x49	5.75	Yes	Yes	3	7	8
74	2x42	4x42	4.35	Yes	No	0	7	7
75	2x42	4x45	6.24	Yes	No	0	7	5
76	2x45	3x42	14.5	No	Yes	4	9	7
77	2x45	4x46	7.45	No	No	4	9	7
78	2x45	4x50	4.52	No	Yes	4	9	9
79	2x46	2x50	4.07	No	Yes	0	9	9
80	2x46	3x43	4.28	No	Yes	0	9	8
81	2x49	3x38	6.52	No	Yes	4	8	7
82	2x49	4x50	3.71	No	Yes	4	8	9
83	2x50	3x39	7.8	Yes	Yes	2	9	9
84	2x50	7x46	9.34	Yes	Yes	2	9	9
85	2x50	7x49	6.73	Yes	Yes	2	9	9
86	2x53	3x32	7.22	No	Yes	2	6	6
87	2x53	7x42	20.63	No	Yes	2	6	6
88	2x53	7x46	6.98	No	Yes	2	6	9
89	2x54	7x46	4.76	No	Yes	0	6	9
90	2x55	2x59	6.43	No	No	0	5	6
91	2x55	3x31	4.29	No	No	0	5	5
92	2x56	2x60	4.85	No	No	0	6	6
93	2x56	3x32	3.75	No	Yes	0	6	6
94	2x57	7x42	11.72	Yes	Yes	0	7	6
95	2x59	E1x52	7.5	No	Yes	0	6	7
96	2x59	3x28	13.4	No	No	0	6	5
97	2x60	2x63	3.86	No	No	0	6	5
98	2x62	2x66	11.06	No	No	0	4	4
99	2x63	E1x50	10.61	No	Yes	1	5	8
100	2x66	E1x49	5.53	No	No	0	4	4
101	E1x49	E1x51	4.38	No	No	0	4	3
102	E1x50	E1x52	16.04	Yes	Yes	0	8	7
103	3x25	E1x50	9.14	No	Yes	1	9	8
104	E1x50	E2x50	11.75	Yes	No	1	8	9
105	E1x51	E1x52	5.24	No	Yes	0	3	7
106	3x24	E1x52	7.46	No	Yes	0	6	7
107	3x22	3x26	8.3	No	No	0	3	7
108	3x22	E2.K173	4.15	No	No	0	3	4
109	3x24	3x28	5.65	No	No	0	6	5
110	3x25	E2.T174	5.07	No	No	0	9	5
111	3x25	E2x50	7.28	No	No	1	9	9
112	3x29	4x65	6.52	No	No	0	5	4
113	3x30	4x62	5.13	No	No	0	5	4
114	3x32	3x33	13.9	Yes	No	0	6	4
115	3x32	6x51	3.97	Yes	Yes	2	6	6
116	3x32	7x38	5.61	Yes	No	2	6	5
117	3x32	7x42	3.97	Yes	Yes	2	6	6
118	3x33	5x39	4.51	No	No	0	4	5
119	3x34	4x54	4.56	No	No	0	5	4
120	3x34	4x57	4.8	No	No	0	5	7
121	3x37	3x41	4.13	Yes	No	0	7	5
122	3x37	4x56	4	Yes	No	0	7	5
123	3x37	5x42	8.36	Yes	No	0	7	3
124	3x37	5x43	5.86	Yes	No	0	7	4
125	3x38	4x50	6.18	Yes	Yes	4	7	9
126	3x39	3x43	4.1	Yes	Yes	2	9	8
127	3x39	6x48	6.54	Yes	Yes	2	9	9
128	3x39	7x45	6.15	Yes	Yes	2	9	9
129	3x39	7x46	4.56	Yes	Yes	2	9	9
130	3x39	7x49	5.26	Yes	Yes	2	9	9
131	3x41	4x49	5.02	No	Yes	0	5	7
132	3x42	4x46	3.96	Yes	No	4	7	7
133	3x42	4x49	10.05	Yes	Yes	0	7	7
134	3x42	4x50	12.03	Yes	Yes	4	7	9
135	3x43	7x49	4.25	Yes	Yes	2	8	9
136	3x43	7x53	8.46	Yes	Yes	2	8	9
137	3x44	5x50	8.47	No	Yes	0	7	9
138	3x45	4x49	5.71	No	Yes	0	7	7
139	3x47	5x58	3.75	No	Yes	0	9	9
140	3x49	I2x57	10.72	Yes	Yes	3	8	7
141	3x50	5x58	7.2	No	Yes	0	9	9
142	3x50	6x40	3.76	No	No	0	9	8
143	3x50	7x53	4.12	No	Yes	0	9	9
144	3x51	3x55	12.62	No	Yes	6	8	8
145	3x51	3x56	8.71	No	No	6	8	6
146	3x51	5x57	8.06	No	No	0	8	8
147	3x53	I2x57	5.53	No	Yes	0	8	7
148	3x55	3x56	5.54	Yes	No	6	8	6
149	3x55	5x64	4.61	Yes	No	0	8	5
150	I2x52	I2x55	4.28	No	No	0	5	4
151	I2x52	I2x56	4.16	No	No	0	5	4
152	4x38	4x41	9.08	No	No	0	7	4
153	4x63	4x64	9.28	No	No	0	4	5
154	4x64	E2.F187	8.57	No	Yes	1	5	5
155	4x64	E2.P188	7.22	No	No	1	5	4
156	E2.K173	E2.Q175	4.07	No	No	1	4	2
157	E2.H186	E2.K173	18.34	Yes	No	1	4	4
158	E2.H181	E2.T174	4.11	No	No	0	4	5
159	E2.H186	E2.Q175	7.42	Yes	No	1	4	2
160	E2.F178	E2.W176	4.01	No	No	0	1	2
161	E2.H181	E2.W176	8.46	No	No	0	4	2
162	E2.E177	E2.H180	8.62	No	No	0	1	1
163	E2.H186	E2x51	6.97	Yes	No	1	4	4
164	E2.F187	E2x52	4.87	Yes	No	0	5	4
165	E2.F187	E2.P188	4.33	Yes	No	1	5	4
166	5x35	E2.F187	5.01	No	Yes	0	1	5
167	5x39	E2.F187	4.68	No	Yes	0	5	5
168	E2.E190	E2.H189	4.92	No	No	1	4	4
169	5x31	5x34	5.75	No	No	0	5	1
170	5x31	5x35	7.41	No	No	0	5	1
171	5x33	6x62	9.53	No	No	1	1	3
172	5x33	6x63	6.41	No	No	0	1	1
173	5x37	5x41	4.15	No	No	0	1	4
174	5x37	6x60	3.65	No	No	0	1	4
175	5x38	5x42	4.96	No	No	0	4	3
176	5x43	6x52	6.87	No	No	0	4	8
177	5x44	6x52	6.81	No	No	0	5	8
178	5x44	6x56	5.49	No	No	0	5	6
179	5x461	5x50	4.06	No	Yes	0	6	9
180	5x47	6x49	4.42	No	Yes	0	8	6
181	5x47	6x52	10.98	No	No	0	8	8
182	5x50	6x44	4.33	Yes	Yes	0	9	9
183	5x51	6x44	4.87	No	Yes	0	6	9
184	5x51	6x45	3.65	No	No	0	6	6
185	5x54	5x58	4.79	No	Yes	0	8	9
186	5x54	6x44	8.71	No	Yes	0	8	9
187	5x58	5x61	4.84	Yes	No	0	9	8
188	5x58	6x37	13.3	Yes	No	0	9	7
189	5x58	6x41	7.18	Yes	No	0	9	8
190	5x62	6x34	4.61	No	No	0	5	7
191	5x62	6x37	5.89	No	No	0	5	7
192	5x62	6x38	3.77	No	No	0	5	5
193	5x65	6x30	4.23	No	No	0	7	7
194	5x65	6x34	4.47	No	No	0	7	7
195	6x27	6x30	5.6	No	No	0	3	7
196	6x28	6x29	5.4	No	No	0	4	4
197	6x36	7x56	5.96	No	No	0	8	7
198	6x38	6x41	3.73	No	No	0	5	8
199	6x40	7x52	7.36	No	No	0	8	8
200	6x43	6x47	5.02	No	Yes	0	6	8
201	6x44	6x48	10.02	Yes	Yes	2	9	9
202	6x44	7x45	4.53	Yes	Yes	2	9	9
203	6x45	6x46	6.09	No	No	0	6	6
204	6x45	6x49	10.38	No	Yes	0	6	6
205	6x47	7x43	3.89	Yes	No	0	8	5
206	6x47	7x45	4.53	Yes	Yes	0	8	9
207	6x47	7x48	3.93	Yes	No	0	8	6
208	6x48	7x41	3.89	Yes	No	0	9	7
209	6x48	7x45	16.93	Yes	Yes	2	9	9
210	6x49	6x50	5.25	Yes	No	0	6	9
211	6x51	6x55	10.88	Yes	No	0	6	5
212	6x51	7x37	7.49	Yes	No	0	6	7
213	6x51	7x38	11.22	Yes	No	2	6	5
214	6x51	7x41	4	Yes	No	0	6	7
215	6x54	7x37	10.99	No	No	0	4	7
216	6x59	6x60	6.55	No	No	0	5	4
217	6x61	7x27	4.33	No	No	0	2	3
218	6x61	7x30	3.99	No	Yes	0	2	4
219	6x65	7x23	7	Yes	No	0	1	4
220	6x65	7x30	7.31	Yes	Yes	0	1	4
221	E3.H271	E3.T270	13.69	No	No	0	1	1
222	7x26	E3.H271	11.13	No	No	0	1	1
223	7x25	7x26	15.29	No	No	0	1	1
224	7x38	7x42	6.73	No	Yes	2	5	6
225	7x45	7x49	14.03	Yes	Yes	2	9	9
226	7x49	7x53	8.14	Yes	Yes	2	9	9
227	7x51	7x55	3.93	No	No	0	6	7
228	7x52	7x53	12.09	No	Yes	0	8	9
229	7x54	8x50	8.32	No	No	0	7	8
230	7x55	8x50	5.36	No	No	0	7	8
231	8x48	8x51	4.65	No	No	0	5	8
232	8x53	8x60	10.29	No	Yes	5	4	5
233	8x54	8x58	7.31	No	No	0	5	6
234	8x56	8x60	7.01	No	Yes	0	4	5
235	8x57	8x60	4.86	No	Yes	5	5	5
236	3x40	5x461	3.53	No	No	0	8	6
237	2x48	4x50	3.52	No	Yes	0	6	9
238	3x46	7x53	3.52	No	Yes	0	9	9
239	6x65	7x26	3.51	Yes	No	0	1	1
240	1x53	7x54	3.39	No	No	0	9	7
241	6x50	7x40	3.39	No	No	0	9	8
242	3x47	5x57	3.38	No	No	0	9	8
243	1x36	2x64	3.35	No	No	0	5	4
244	5x49	5x50	3.28	No	Yes	0	6	9
245	3x53	3x54	3.25	No	No	0	8	9
246	3x41	5x46	3.22	No	No	0	5	5
247	E2.T182	E2x51	3.2	No	No	0	3	4
248	3x47	5x53	3.17	No	No	0	9	7
249	2x43	7x54	3.15	No	No	0	8	7
250	2x41	4x39	3.07	No	No	0	6	1
251	3x48	5x53	3.07	No	No	0	7	7
252	4x40	4x44	3.04	No	No	0	3	3
253	5x36	6x59	3.04	No	No	0	4	5
254	1x30	1x31	3.01	No	No	0	6	1
255	4x57	4x62	3	No	No	0	7	4
256	6x58	7x30	3	No	Yes	0	3	4
257	1x42	2x57	2.98	No	Yes	0	7	7
258	5x66	6x34	2.98	No	No	0	4	7
259	6x49	6x53	2.95	Yes	No	0	6	6
260	4x44	4x48	2.94	No	No	0	3	3
261	3x48	3x52	2.85	No	No	0	7	5
262	4x48	4x52	2.85	No	No	0	3	4
263	5x52	5x56	2.85	No	No	0	3	4
264	1x57	2x44	2.77	No	No	0	7	6
265	3x36	5x43	2.77	No	No	0	7	4
266	I2x53	I2x57	2.77	No	Yes	0	5	7
267	5x41	5x45	2.77	No	No	0	4	5
268	1x50	2x51	2.75	No	No	0	9	7
269	1x33	1x34	2.66	No	No	0	3	6
270	3x33	4x57	2.54	No	No	0	4	7
271	3x27	3x31	2.51	No	No	0	5	5
272	I1x48	I1x49	2.48	No	No	0	6	5
273	5x63	5x67	2.48	No	No	0	4	4
274	6x32	6x35	2.48	No	No	0	7	5
275	1x43	2x57	2.44	No	Yes	0	5	7
276	1x52	7x55	2.44	No	No	0	6	7
277	2x52	4x50	2.28	No	Yes	0	6	9
278	3x56	I2x52	2.26	No	No	0	6	5
279	1x49	7x50	2.03	No	No	0	7	9
280	3x29	3x30	1.86	No	No	0	5	5
281	3x29	4x61	1.86	No	No	0	5	5
282	3x35	3x38	1.86	No	Yes	0	8	7
283	1x48	1x49	1.84	No	No	0	3	7
284	3x55	5x60	1.84	Yes	No	0	8	4
285	7x56	8x47	1.84	No	No	0	7	8
286	5x59	5x60	1.82	No	No	0	3	4
287	2x41	4x42	1.76	No	No	0	6	7
288	3x21	3x24	1.75	No	No	0	7	6
289	5x60	5x63	1.74	No	No	0	4	4
290	1x42	7x47	1.71	No	No	0	7	8
291	1x46	2x54	1.71	No	No	0	8	6
292	3x38	4x53	1.71	Yes	No	0	7	8
293	1x53	2x47	1.7	No	No	0	9	8
294	1x54	2x47	1.7	No	No	0	7	8
295	5x40	6x59	1.7	No	No	0	5	5
296	4x59	4x60	1.68	No	No	0	4	7
297	4x60	5x42	1.67	No	No	0	7	3
298	8x47	8x48	1.64	No	No	0	8	5
299	4x39	4x43	1.6	No	No	0	1	4
300	7x36	7x37	1.59	No	No	0	6	7
301	5x65	6x33	1.58	No	No	0	7	7
302	4x38	4x40	1.57	No	No	0	7	3
303	1x40	2x61	1.55	No	No	0	5	7
304	1x44	1x45	1.54	No	No	0	6	6
305	6x39	6x43	1.54	No	No	0	6	6
306	2x40	I1x51	1.53	No	No	0	8	6
307	5x55	5x59	1.52	No	No	0	4	3
308	Lig	NT.G19	1.5	Yes	No	0	0	3
309	1x38	7x39	1.49	No	No	0	5	5
310	I3.P230	I3.R229	1.44	No	No	0	3	5
311	4x49	4x52	1.43	Yes	No	0	7	4
312	6x36	6x40	1.43	No	No	0	8	8
313	6x42	6x46	1.43	No	No	0	5	6
314	6x57	7x30	1.43	No	Yes	0	5	4
315	6x32	6x36	1.41	No	No	0	7	8
316	E2.H180	E2.T179	1.37	No	No	0	1	5
317	8x52	8x56	1.36	No	No	0	5	4
318	6x29	8x48	1.35	No	No	0	4	5
319	6x60	6x64	1.22	No	No	0	4	1
320	6x64	6x65	1.22	No	Yes	0	1	1
321	I1x49	I1x50	1.21	No	No	0	5	7
322	8x58	8x59	1.13	No	No	0	6	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg. Int. Strength	Num. Of Links	Community	ConSurf
1	Lig	28.5713	32	1	0
2	1x39	6.8475	4	0	7
3	1x60	8.5425	4	0	4
4	2x42	9.178	5	3	7
5	2x50	7.742	5	2	9
6	2x57	6.9225	4	0	7
7	E1x50	11.885	4	1	8
8	E1x52	9.06	4	0	7
9	3x32	6.40333	6	2	6
10	3x37	5.5875	4	0	7
11	3x38	4.0675	4	4	7
12	3x39	5.735	6	2	9
13	3x42	10.135	4	4	7
14	3x43	5.2725	4	2	8
15	3x49	8.7275	4	3	8
16	3x55	6.1525	4	6	8
17	I2x57	5.86333	6	3	7
18	4x49	5.5525	4	0	7
19	4x50	5.37333	6	4	9
20	E2.H186	11.9075	4	1	4
21	E2.F187	5.67833	6	1	5
22	5x50	5.035	4	0	9
23	5x58	6.84333	6	0	9
24	6x44	6.492	5	2	9
25	6x47	4.3425	4	0	8
26	6x48	9.345	4	2	9
27	6x49	5.75	4	0	6
28	6x51	7.512	5	2	6
29	6x65	4.76	4	0	1
30	7x30	3.9325	4	0	4
31	7x42	10.7625	4	2	6
32	7x45	9.234	5	2	9
33	7x46	6.41	4	2	9
34	7x49	7.682	5	2	9
35	7x53	7.266	5	2	9
36	8x60	7.8775	4	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	1x24	Lig	11.0221	4.38	No	Yes	1	3	0
2	1x39	2x57	15.2502	10.55	Yes	Yes	0	7	7
3	2x50	7x46	14.1515	9.34	Yes	Yes	2	9	9
4	2x53	7x46	48.7513	6.98	No	Yes	2	6	9
5	2x53	3x32	32.6759	7.22	No	Yes	2	6	6
6	2x56	3x32	52.9271	3.75	No	Yes	0	6	6
7	2x56	2x60	52.4803	4.85	No	No	0	6	6
8	2x60	2x63	52.0597	3.86	No	No	0	6	5
9	2x63	Lig	43.9496	20.63	No	Yes	1	5	0
10	3x32	3x33	51.3171	13.9	Yes	No	0	6	4
11	3x33	5x39	47.2601	4.51	No	No	0	4	5
12	5x39	E2.F187	46.8395	4.68	No	Yes	0	5	5
13	E2.F187	Lig	43.529	6.61	Yes	Yes	1	5	0
14	7x55	8x50	14.3849	5.36	No	No	0	7	8
15	7x54	8x50	19.2329	8.32	No	No	0	7	8
16	2x43	7x54	23.7629	3.15	No	No	0	8	7
17	1x57	2x43	26.1697	6.92	No	No	0	7	8
18	1x57	1x60	35.8234	9.38	No	Yes	0	7	4
19	1x60	2x40	61.645	10.17	Yes	No	0	4	8
20	2x37	2x40	66.336	4.47	No	No	0	7	8
21	2x37	2x39	22.8512	5.85	No	No	3	7	8
22	2x39	3x49	23.5858	10.12	No	Yes	3	8	8
23	2x42	3x49	50.1519	5.75	Yes	Yes	3	7	8
24	2x42	3x45	80.3586	17.58	Yes	No	0	7	7
25	3x45	4x49	80.9281	5.71	No	Yes	0	7	7
26	3x41	4x49	89.9942	5.02	No	Yes	0	5	7
27	3x37	3x41	90.9843	4.13	Yes	No	0	7	5
28	3x37	5x43	93.858	5.86	Yes	No	0	7	4
29	5x43	6x52	94.7838	6.87	No	No	0	4	8
30	5x47	6x52	96.1422	10.98	No	No	0	8	8
31	5x47	6x49	96.5869	4.42	No	Yes	0	8	6
32	6x45	6x49	98.3257	10.38	No	Yes	0	6	6
33	5x51	6x45	99.5875	3.65	No	No	0	6	6
34	5x51	6x44	100	4.87	No	Yes	0	6	9
35	6x44	6x48	89.2999	10.02	Yes	Yes	2	9	9
36	6x48	7x41	81.723	3.89	Yes	No	0	9	7
37	6x51	7x41	81.5922	4	Yes	No	0	6	7
38	3x32	6x51	75.1706	3.97	Yes	Yes	2	6	6
39	2x37	I2x57	45.8192	6.03	No	Yes	3	7	7
40	3x49	I2x57	25.9765	10.72	Yes	Yes	3	8	7
41	2x38	I2x57	25.9745	4.96	No	Yes	3	7	7
42	2x38	2x42	26.699	11.97	No	Yes	3	7	7
43	1x60	8x53	16.8018	9.93	Yes	No	0	4	4
44	3x39	3x43	12.9863	4.1	Yes	Yes	2	9	8
45	3x39	7x46	41.261	4.56	Yes	Yes	2	9	9
46	2x50	7x49	14.085	6.73	Yes	Yes	2	9	9
47	3x39	7x49	11.7184	5.26	Yes	Yes	2	9	9
48	2x57	7x42	25.0569	11.72	Yes	Yes	0	7	6
49	E1x50	E1x52	10.9597	16.04	Yes	Yes	0	8	7
50	2x63	E1x50	14.7049	10.61	No	Yes	1	5	8
51	3x39	7x45	13.6242	6.15	Yes	Yes	2	9	9
52	7x49	7x53	24.4169	8.14	Yes	Yes	2	9	9
53	3x47	5x58	17.959	3.75	No	Yes	0	9	9
54	5x54	5x58	28.0755	4.79	No	Yes	0	8	9
55	5x54	6x44	28.8	8.71	No	Yes	0	8	9
56	3x51	5x57	12.7971	8.06	No	No	0	8	8
57	3x47	5x57	13.8375	3.38	No	No	0	9	8
58	5x36	Lig	10.9678	4.59	No	Yes	1	4	0
59	8x47	8x48	12.1189	1.64	No	No	0	8	5
60	7x56	8x47	15.1396	1.84	No	No	0	7	8
61	6x36	7x56	18.1361	5.96	No	No	0	8	7
62	6x36	6x40	27.1639	1.43	No	No	0	8	8
63	3x50	6x40	16.7576	3.76	No	No	0	9	8
64	3x50	7x53	18.6472	4.12	No	Yes	0	9	9
65	3x43	7x53	11.495	8.46	Yes	Yes	2	8	9
66	6x40	7x52	12.9983	7.36	No	No	0	8	8
67	7x52	7x53	14.6043	12.09	No	Yes	0	8	9
68	6x61	Lig	16.3993	5.78	No	Yes	1	2	0
69	6x61	7x30	13.8295	3.99	No	Yes	0	2	4
70	2x53	7x42	15.3931	20.63	No	Yes	2	6	6
71	3x39	6x48	12.0545	6.54	Yes	Yes	2	9	9
72	6x44	7x45	17.1822	4.53	Yes	Yes	2	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
7x31	Lig	12.19	1	No	Yes	3	0	1	0
7x34	Lig	11.07	0	No	Yes	4	0	1	0
7x35	Lig	6.18	1	No	Yes	3	0	1	0
1x28	Lig	18.32	1	No	Yes	2	0	1	0
2x63	Lig	20.63	1	No	Yes	5	0	1	0
2x64	Lig	8.69	1	No	Yes	4	0	1	0
2x67	Lig	7.17	0	No	Yes	3	0	1	0
1x24	Lig	4.38	1	No	Yes	3	0	1	0
Lig	NT.Q25	15.56	1	Yes	No	0	3	0	1
Lig	NT.P23	14.15	1	Yes	No	0	2	0	1
7x24	Lig	6.76	1	No	Yes	8	0	1	0
Lig	NT.A21	5.04	1	Yes	No	0	2	0	1
Lig	NT.Y18	33.68	1	Yes	No	0	7	0	1
Lig	NT.D20	18.24	1	Yes	No	0	3	0	1
Lig	NT.D17	7.83	1	Yes	No	0	8	0	1
E2.F178	Lig	17.21	1	No	Yes	1	0	1	0
E2.Q175	Lig	23.84	1	No	Yes	2	0	1	0
E2.E177	Lig	17.49	1	No	Yes	1	0	1	0
E2.H186	Lig	14.9	1	Yes	Yes	4	0	1	0
E2.H189	Lig	20.83	1	No	Yes	4	0	1	0
E2x51	Lig	6.13	1	No	Yes	4	0	1	0
E2.F187	Lig	6.61	1	Yes	Yes	5	0	1	0
5x32	Lig	9.57	0	No	Yes	2	0	1	0
5x36	Lig	4.59	1	No	Yes	4	0	1	0
5x33	Lig	6.51	1	No	Yes	1	0	1	0
6x61	Lig	5.78	1	No	Yes	2	0	1	0
6x62	Lig	5.89	1	No	Yes	3	0	1	0
Lig	NT.T22	6.47	1	Yes	No	0	5	0	1
E2.E190	Lig	4.31	1	No	Yes	4	0	1	0
7x24	NT.C24	7.28	1	No	No	8	9	1	2
1x24	7x28	7.43	1	No	No	3	2	1	2
1x24	7x31	4.15	1	No	No	3	3	1	1
1x25	1x28	3.92	0	No	No	1	2	2	1
1x35	7x35	7.99	0	No	No	5	3	2	1
2x60	2x63	3.86	0	No	No	6	5	2	1
2x63	E1x50	10.61	1	No	Yes	5	8	1	2
4x64	E2.F187	8.57	1	No	Yes	5	5	2	1
4x64	E2.P188	7.22	1	No	No	5	4	2	2
E2.K173	E2.Q175	4.07	1	No	No	4	2	2	1
E2.H186	E2.K173	18.34	1	Yes	No	4	4	1	2
E2.H186	E2.Q175	7.42	1	Yes	No	4	2	1	1
E2.F178	E2.W176	4.01	1	No	No	1	2	1	2
E2.E177	E2.H180	8.62	1	No	No	1	1	1	2
E2.H186	E2x51	6.97	1	Yes	No	4	4	1	1
E2.F187	E2x52	4.87	1	Yes	No	5	4	1	2
E2.F187	E2.P188	4.33	1	Yes	No	5	4	1	2
5x35	E2.F187	5.01	0	No	Yes	1	5	2	1
5x39	E2.F187	4.68	0	No	Yes	5	5	2	1
E2.E190	E2.H189	4.92	1	No	No	4	4	1	1
5x33	6x62	9.53	1	No	No	1	3	1	1
5x33	6x63	6.41	1	No	No	1	1	1	2
6x61	7x27	4.33	1	No	No	2	3	1	2
6x61	7x30	3.99	1	No	Yes	2	4	1	2
1x36	2x64	3.35	0	No	No	5	4	2	1
E2.T182	E2x51	3.2	0	No	No	3	4	2	1
5x36	6x59	3.04	1	No	No	4	5	1	2
Lig	NT.G19	1.5	1	Yes	No	0	3	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Similarity	Network Type	Name	Ligand	Description
100.00	Single	7VLA	CCL15(27-92)	7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
100.00	Consensus	ccr1_on_gp	Orthosteric Ligand	7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
58.33	Single	7VL9	CCL15(26-92)	7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
58.33	Consensus	ccr_on_gp	Orthosteric Ligand	ccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
54.55	Consensus	chemokine_on	Orthosteric Ligand	ccr_on cxcr_on
50.00	Single	7F1T	MIP-1a	7F1T-CCR5-MIP-1a
50.00	Single	8XX6	CXCL8	8XX6-CXCR2-CXCL8-Go/β1/γ2
50.00	Consensus	ccr_on	Orthosteric Ligand	ccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
47.83	Single	8XWN	CXCL8	8XWN-CXCR2-CXCL8
46.15	Consensus	chemokine_on_gp	Orthosteric Ligand	ccr_on_gp cxcr_on_gp
46.15	Consensus	gi_chemokine	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
43.48	Single	6KNM	JN241-9	6KNM-Apelin-JN241-9
42.86	Single	7SK7	CXCL12	7SK7-ACKR3-CXCL12-CCX662
42.86	Single	8XX7	CXCL5	8XX7-CXCR2-CXCL5-Go/β1/γ2
41.67	Single	8U4O	CXCL12	8U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
40.91	Single	8XWA	CXCL1	8XWA-CXCR2-CXCL1
40.91	Single	8XWS	CXCL5	8XWS-CXCR2-CXCL5
40.91	Single	8XX3	CXCL3	8XX3-CXCR2-CXCL3-Go/β1/γ2
40.00	Single	7C6A	(Sar1,Ile8)-Angiotensin II	7C6A-AT₂-(Sar1,Ile8)-Angiotensin II
40.00	Single	7F1Q	MIP-1a	7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
40.00	Single	7RKM	Fractalkine	7RKM-US28-Fractalkine-Gi1/β1/γ2
40.00	Single	8U1U	CCL1	8U1U-CCR8-CCL1-Gi1/β1/γ2
39.29	Single	5UIW	5P7-CCL5	5UIW-CCR5-5P7-CCL5
39.29	Consensus	ccr5_off	Orthosteric Ligand	5UIW-CCR5-5P7-CCL5
39.29	Consensus	ccr5_on	Orthosteric Ligand	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
39.13	Single	8XWF	CXCL3	8XWF-CXCR2-CXCL3
39.13	Single	8XWV	CXCL1	8XWV-CXCR2-CXCL1-Go/β1/γ2
38.10	Single	6LFM	Interleukin-8	6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
38.10	Consensus	cxcr2_on_gp	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
37.50	Single	7RKN	Fractalkine	7RKN-US28-Fractalkine-Gi1/β1/γ2
37.50	Single	9EAJ	Nanobody AT209	9EAJ-AT₁-Nanobody AT209
37.04	Consensus	protein_offon	Orthosteric Ligand	protein_off protein_on
37.04	Consensus	protein_offon_gp	Orthosteric Ligand	protein_on_gp protein_off
36.84	Single	8U4S	REGN7663-Fab	8U4S-CXCR4-REGN7663-Fab
36.84	Single	8U4T	REGN7663-Fab	8U4T-CXCR4-REGN7663-Fab
36.84	Consensus	p2y1_on	Orthosteric Ligand	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
36.36	Single	6OS1	TRV026	6OS1-AT₁-TRV026
36.00	Single	7W2Z	Ghrelin	7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
35.71	Single	7F9Y	Ghrelin-28	7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
35.71	Consensus	chemokine_off	Orthosteric Ligand	ccr_off cxcr_off
35.71	Consensus	cxcr_off	Orthosteric Ligand	cxcr3_off cxcr4_off
35.48	Consensus	ccr5_on_gp	Orthosteric Ligand	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
35.00	Single	7XXH	2MeSADP	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
35.00	Consensus	cxcr2_on	Orthosteric Ligand	6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
35.00	Consensus	p2y1_on_gp	Orthosteric Ligand	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
34.78	Single	6OS2	TRV026	6OS2-AT₁-TRV026
34.78	Single	8XQJ	JN241	8XQJ-Apelin-JN241
34.78	Single	8XWM	CXCL6	8XWM-CXCR2-CXCL6
34.78	Single	8ZPL	HF51116	8ZPL-CXCR4-HF51116-Cholesterol
34.48	Single	7SK3	CXCL12	7SK3-ACKR3-CXCL12
34.48	Consensus	ccr_off	Orthosteric Ligand	ccr2_off ccr5_off
34.38	Single	7SK6	CXCL12_LRHQ	7SK6-ACKR3-CXCL12_LRHQ
33.33	Single	3OE0	CVX15	3OE0-CXCR4-CVX15
33.33	Single	4RWS	vMIP-II	4RWS-CXCR4-vMIP-II
33.33	Single	6MEO	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
33.33	Single	6OIK	LY2119620	6OIK-M₂-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
33.33	Single	7O7F	6P4-CCL5	7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
33.33	Single	7SK8	CXCL12	7SK8-ACKR3-CXCL12-CCX662
33.33	Single	7TRQ	VU0467154	7TRQ-M₄-Iperoxo-VU0467154-Gi1/β1/γ2
33.33	Single	7XA3	CCL2	7XA3-CCR2-CCL2-Gi1/β1/γ2
33.33	Single	8IC0	Interleukin-8	8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
33.33	Single	8TH3	AT118-H Nanobody	8TH3-AT₁-AT118-H Nanobody
33.33	Single	8XVU	CXCL2	8XVU-CXCR2-CXCL2
33.33	Single	8XXH	CXCL2	8XXH-CXCR2-CXCL2-Go/β1/γ2
33.33	Consensus	ccr2_on	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/β1/γ2
33.33	Consensus	ccr2_on_gp	Orthosteric Ligand	7XA3-CCR2-CCL2-Gi1/β1/γ2
33.33	Consensus	cxcr1_on_gp	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
32.14	Single	6JOD	Angiotensin II	6JOD-AT₂-Angiotensin II
32.14	Single	6MET	Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4	6MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
32.14	Single	8XZJ	WN353	8XZJ-Apelin-WN353-Gi1/β1/γ2
32.14	Consensus	p2y_on_gp	Orthosteric Ligand	p2y1_on_gp p2y10_on_gp p2y12_on_gp
32.00	Single	8XQJ	JN241	8XQJ-Apelin-JN241
32.00	Consensus	cxcr4_off	Orthosteric Ligand	4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
31.82	Single	8TH4	AT118-L Nanobody	8TH4-AT₁-Losartan-AT118-L Nanobody
31.82	Single	9EAH	Nanobody AT209	9EAH-AT₁-Olmesartan-Nanobody AT209
31.58	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/β1/γ2
31.58	Consensus	gq_nucleotide	Orthosteric Ligand	gq_p2y
31.58	Consensus	gq_p2y	Orthosteric Ligand	7XXH-P2Y₁-2MeSADP-chim(NtGi1-G11)/β1/γ2
31.03	Single	8XVI	Endothelin-1	8XVI-ET_A-Endothelin-1-chim(Gs-CtGq)/β1/γ2
30.77	Single	4XT1	Fractalkine	4XT1-US28-Fractalkine
30.77	Single	8K3Z	CXCL12	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
30.77	Consensus	p2y_on	Orthosteric Ligand	p2y1_on p2y10_on p2y12_on
30.43	Consensus	motilin_on	Orthosteric Ligand	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
30.30	Consensus	endothelin_on_gp	Orthosteric Ligand	etb_on_gp eta_on_gp
30.00	Single	4XT3	Fractalkine	4XT3-US28-Fractalkine
30.00	Single	6LFO	Interleukin-8	6LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
30.00	Single	6WWZ	CCL20	6WWZ-CCR6-CCL20-Go/β1/γ2
30.00	Single	8XXX	CXCL6	8XXX-CXCR2-CXCL6-Go/β1/γ2
30.00	Consensus	ccr6_on	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/β1/γ2
30.00	Consensus	ccr6_on_gp	Orthosteric Ligand	6WWZ-CCR6-CCL20-Go/β1/γ2
30.00	Consensus	cxcr1_on	Orthosteric Ligand	8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
30.00	Consensus	gi_protein	Orthosteric Ligand	gi_chemokine gi_chemerin
30.00	Consensus	protein_on_gp	Orthosteric Ligand	chemokine_on_gp chemerin_on_gp
29.63	Single	5XJM	(Sar1,Ile8)-Angiotensin II	5XJM-AT₂-(Sar1,Ile8)-Angiotensin II
29.63	Single	6DO1	Angiotensin-like peptide S1I8	6DO1-AT₁-Angiotensin-like peptide S1I8
29.63	Single	7SK5	CXCL12	7SK5-ACKR3-CXCL12
29.63	Single	7XNA	CYN154806	7XNA-SST2-CYN154806
29.63	Single	8IBV	Motilin	8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
29.63	Single	8WSS	Pro-MCH	8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
29.63	Single	9EAI	Nanobody AT209	9EAI-AT₁-Losartan-Nanobody AT209
29.63	Consensus	compl-peptide_on	Orthosteric Ligand	c5a1_on c3a_on
29.63	Consensus	gi_ghrelin	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
29.63	Consensus	sst2_off	Orthosteric Ligand	7XNA-SST2-CYN154806
29.17	Single	7WQ4	Galanin	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17	Single	8IBU	Erythromycin-A	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17	Consensus	ccr8_on	Orthosteric Ligand	8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
29.17	Consensus	cxcr_on	Orthosteric Ligand	cxcr3_on cxcr4_on cxcr1_on cxcr2_on
29.17	Consensus	motilin_on_gp	Orthosteric Ligand	8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57	Single	6U1N	LY2119620	6U1N-M₂-LY2119620-Arrestin2
28.57	Single	6WJC	Muscarinic toxin 7	6WJC-M₁-Atropine-Muscarinic toxin 7
28.57	Single	7T94	PubChem 57664406	7T94-M₂-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
28.57	Single	7W55	Neuromedin-U-25	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57	Consensus	angiotensin_on	Orthosteric Ligand	at1_on
28.57	Consensus	at1_on	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
28.57	Consensus	c5a1_on	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
28.57	Consensus	compl-peptide_on_gp	Orthosteric Ligand	c5a1_on_gp c3a_on_gp
28.57	Consensus	cxcr4_on_gp	Orthosteric Ligand	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
28.57	Consensus	nmur2_on	Orthosteric Ligand	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57	Consensus	nmur2_on_gp	Orthosteric Ligand	7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
28.12	Single	8IY5	Endothelin-1	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2
28.12	Single	8IY6	Endothelin-1	8IY6-ET_B-Endothelin-1
28.12	Consensus	bk2_on	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
28.12	Consensus	bk2_on_gp	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
28.12	Consensus	bradykinin_on	Orthosteric Ligand	bk2_on
28.12	Consensus	bradykinin_on_gp	Orthosteric Ligand	bk2_on_gp
28.12	Consensus	gq_bradykinin	Orthosteric Ligand	7F6H-BK₂-Bradykinin-Gq/β1/γ2 7F6I-BK₂-Kallidin-Gq/β1/γ2
28.00	Single	6UP7	Neurotensin	6UP7-NTS₁-Neurotensin-Arrestin2
28.00	Single	8HN1	Toxin AdTx1	8HN1-Alpha1A-Toxin AdTx1
28.00	Single	8K4O	CXCL1	8K4O-KSHV-CXCL1-Gi1/β1/γ1
28.00	Consensus	gal2_on	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.00	Consensus	gal2_on_gp	Orthosteric Ligand	7WQ4-GAL₂-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.78	Single	8U4Q	REGN7663-Fab	8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
27.78	Consensus	p2y_off	Orthosteric Ligand	p2y1_off
27.59	Single	5WB2	CX3CL1.35	5WB2-US28-CX3CL1.35
27.59	Single	7F6G	SAR1-AngII	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
27.59	Single	8X8L	Cortistatin	8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
27.59	Consensus	angiotensin_on_gp	Orthosteric Ligand	at1_on_gp
27.59	Consensus	at1_on_gp	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
27.59	Consensus	c5a1_on_gp	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
27.59	Consensus	gq_angiotensin	Orthosteric Ligand	7F6G-AT₁-SAR1-AngII-Gq/β1/γ2
27.59	Consensus	protein_on	Orthosteric Ligand	chemokine_on chemerin_on
27.27	Single	6D27	CAY10471	6D27-DP₂-CAY10471
27.27	Single	6IGK	Endothelin-3	6IGK-ET_B-Endothelin-3
27.27	Single	7WQ3	Galanin	7WQ3-GAL₁-Galanin-Gi1/β1/γ2
27.27	Consensus	gal1_on	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/β1/γ2
27.27	Consensus	gal1_on_gp	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/β1/γ2
27.27	Consensus	gi_galanin	Orthosteric Ligand	7WQ3-GAL₁-Galanin-Gi1/β1/γ2
27.27	Consensus	gi_npy	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
27.27	Consensus	npy_on	Orthosteric Ligand	npy1_on npy2_on npy4_on
27.27	Consensus	npy_on_gp	Orthosteric Ligand	npy1_on_gp npy2_on_gp npy4_on_gp
26.92	Single	5VBL	Apelin mimetic peptide agonist	5VBL-Apelin-Apelin mimetic peptide agonist
26.92	Single	6OS9	JMV449	6OS9-NTS₁-JMV449-Gi1/β1/γ2
26.92	Single	7RKF	Fractalkine	7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
26.92	Single	7Y1F	Dynorphin	7Y1F-κ-Dynorphin-Gi1/β1/γ2
26.92	Single	8Z74	Agonistic antibody	8Z74-Apelin-Agonistic antibody
26.92	Single	8Z74	Agonistic antibody	8Z74-Apelin-Agonistic antibody
26.92	Consensus	cxcr_on_gp	Orthosteric Ligand	cxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
26.67	Single	7F6H	Bradykinin	7F6H-BK₂-Bradykinin-Gq/β1/γ2
26.67	Single	7F6I	Kallidin	7F6I-BK₂-Kallidin-Gq/β1/γ2
26.67	Single	7Y64	C5a anaphylatoxin	7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
26.67	Single	8HCX	Endothelin-1	8HCX-ET_B-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.67	Single	8HK5	Complement C5	8HK5-C5a₁-Complement C5-Gi1/β1/γ2
26.67	Single	8HNK	CXCL11	8HNK-CXCR3-CXCL11-Gi1/β1/γ2
26.67	Single	8WWM	MCH	8WWM-MCH1-MCH-Gi1/β1/γ2
26.32	Single	4XNW	MRS2500	4XNW-P2Y₁-MRS2500
26.32	Consensus	p2y1_off	Orthosteric Ligand	4XNW-P2Y₁-MRS2500
25.93	Single	7NA7	Ghrelin-27	7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
25.93	Single	7XMR	Somatostatin-14	7XMR-SST2-Somatostatin-14-Gi1/β1/γ2
25.93	Consensus	somatostatin_off	Orthosteric Ligand	sst2_off
25.81	Single	7SK4	CXCL12_LRHQ	7SK4-ACKR3-CXCL12_LRHQ
25.81	Consensus	gi_compl-pept	Orthosteric Ligand	8HK5-C5a₁-Complement C5-Gi1/β1/γ2 8IA8-C3a_B-E7 peptide-Gi1/β1/γ2 7Y66-C5a₁-BM213-Gi1/β1/γ2 7Y67-C5a₁-C089 peptide-Gi1/β1/γ2 8HK2-C3a_B-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a₁-C5a anaphylatoxin-Gi1/β1/γ2
25.81	Consensus	gi_peptide	Orthosteric Ligand	gi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
25.81	Consensus	npy4_on	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
25.81	Consensus	npy4_on_gp	Orthosteric Ligand	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
25.00	Single	7L0P	Neurotensin	7L0P-NTS₁-Neurotensin-Gi1/β1/γ1
25.00	Single	7L0Q	Neurotensin	7L0Q-NTS₁-Neurotensin-Gi1/β1/γ1
25.00	Single	7T96	LY2119620	7T96-M₂-Acetylcholine-LY2119620-Go/β1/γ2
25.00	Single	7TRP	LY2033298	7TRP-M₄-Iperoxo-LY2033298-Gi1/β1/γ2
25.00	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/β1/γ2
25.00	Single	7X9A	Neuropeptide-Y	7X9A-Y₁-Neuropeptide-Y-Gi1/β1/γ2
25.00	Single	7XBD	Galanin	7XBD-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00	Single	7XJL	Spexin	7XJL-GAL₂-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00	Single	7Y67	C089 peptide	7Y67-C5a₁-C089 peptide-Gi1/β1/γ2
25.00	Single	8K6O	Pro-neuropeptide-Y	8K6O-Y₁-Pro-neuropeptide-Y-Gi2/β1/γ1
25.00	Single	8WJX	ADP	8WJX-P2Y₁-ADP-chim(Gs-CtGq)/β1/γ2
25.00	Single	8WWL	MCH	8WWL-MCH1-MCH-Gi1/β1/γ2
25.00	Single	9AST	Lymphotactin	9AST-XCR1-Lymphotactin-Gi1/β1/γ2
25.00	Consensus	ccr8_on_gp	Orthosteric Ligand	8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
25.00	Consensus	gq_class-a	Orthosteric Ligand	gq_peptide gq_amine gq_nucleotide
24.24	Single	6IGL	IRL1620	6IGL-ET_B-IRL1620
24.24	Single	8WWN	MCH	8WWN-MCH1-MCH-Gi1/β1/γ2
24.24	Consensus	endothelin_on	Orthosteric Ligand	etb_on eta_on
24.14	Single	8K6M	Neuropeptide-Y	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1
24.14	Single	8XZH	MM07	8XZH-Apelin-MM07-Gi1/β1/γ2
24.14	Consensus	npy1_on	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1
24.14	Consensus	npy1_on_gp	Orthosteric Ligand	8K6M-Y₁-Neuropeptide-Y-Gi2/β1/γ1
24.00	Single	4GRV	Neurotensin-(8-13)	4GRV-NTS₁-Neurotensin-(8-13)
24.00	Single	4XEE	Neurotensin	4XEE-NTS₁-Neurotensin
24.00	Single	4XES	Neurotensin	4XES-NTS₁-Neurotensin
24.00	Single	6C1R	PMX53	6C1R-C5a₁-PMX53-Avacopan; Na
24.00	Single	6OSA	JMV449	6OSA-NTS₁-JMV449-Gi1/β1/γ2
24.00	Single	6YVR	NTS8-13	6YVR-NTS₁-NTS8-13
24.00	Single	7W0N	Elabela	7W0N-Apelin-Elabela-Gi1/β1/γ2
24.00	Single	7XJK	Galanin	7XJK-GAL₂-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.00	Single	8HK2	C3a anaphylatoxin	8HK2-C3a_B-C3a anaphylatoxin-Gi1/β1/γ2
24.00	Single	8J6D	EP141	8J6D-C3a_B-EP141-Go/β1/γ2
24.00	Single	8JPB	Neurotensin-(8-13)	8JPB-NTS₁-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
24.00	Single	8JPC	Neurotensin-(8-13)	8JPC-NTS₁-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
24.00	Single	8U26	Protachykinin-1	8U26-NK₁-Protachykinin-1-Gs/β1/γ2
24.00	Consensus	galanin_on	Orthosteric Ligand	gal2_on gal1_on
24.00	Consensus	galanin_on_gp	Orthosteric Ligand	gal2_on_gp gal1_on_gp
24.00	Consensus	gi_neurotensin	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
24.00	Consensus	neurotensin_on_gp	Orthosteric Ligand	nts1_on_gp
24.00	Consensus	nts1_on_gp	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
23.81	Single	4BWB	Neurotensin	4BWB-NTS₁-Neurotensin
23.81	Single	4MQT	LY2119620	4MQT-M₂-Iperoxo-LY2119620
23.81	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/β1/γ2
23.81	Single	7XJJ	Galanin	7XJJ-GAL₁-Galanin-Go/β1/γ2
23.33	Single	8WST	Pro-MCH	8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.33	Consensus	neuromedin-u_on	Orthosteric Ligand	nmur1_on nmur2_on
23.08	Single	7EZM	Cholecystokinin-8	7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
23.08	Single	8FN0	Neurotensin/Neuromedin-N	8FN0-NTS₁-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
23.08	Single	8JPF	Neurotensin	8JPF-NTS₁-Neurotensin-PubChem 118610427
23.08	Consensus	prostanoid_off	Orthosteric Ligand	ep_off dp_off
22.73	Single	7C2E	PubChem 149050799	7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
22.73	Single	8RWI	StilSwitch2	8RWI-A_2A-StilSwitch2-Na
22.73	Single	8ZPM	AMD070	8ZPM-CXCR4-AMD070-Cholesterol
22.73	Consensus	nucleotide_off	Orthosteric Ligand	adenosine_off p2y_off
22.58	Single	7X9C	Pancreatic Hormone	7X9C-Y₄-Pancreatic Hormone-Gi1/β1/γ2
22.58	Single	8HCQ	Endothelin-1	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
22.58	Single	8IA2	C5a anaphylatoxin	8IA2-C5a₁-C5a anaphylatoxin-Go/β1/γ2
22.58	Single	8XVH	Endothelin-1	8XVH-ET_B-Endothelin-1-chim(Gs-CtGq)/β1/γ2
22.58	Consensus	eta_on	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
22.58	Consensus	eta_on_gp	Orthosteric Ligand	8HCQ-ET_A-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
22.58	Consensus	gi_apelin	Orthosteric Ligand	8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
22.58	Consensus	neuromedin-u_on_gp	Orthosteric Ligand	nmur1_on_gp nmur2_on_gp
22.22	Single	6C1Q	PMX53	6C1Q-C5a₁-PMX53-NDT9513727
22.22	Single	6LRY	Sarafotoxin-B	6LRY-ET_B-Sarafotoxin-B
22.22	Single	7F2O	Bradykinin	7F2O-BK₂-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22	Single	7RMG	Substance-P	7RMG-NK₁-Substance-P-chim(Gs-CtGq)/β1/γ2
22.22	Single	7RMH	Substance-P	7RMH-NK₁-Substance-P-Gs/β1/γ2
22.22	Single	7XBX	CX3CL1	7XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
22.22	Single	7YAE	Octreotide	7YAE-SST2-Octreotide-Gi1/β1/γ2
22.22	Consensus	gq_cck	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCK_A-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
21.88	Single	7F8V	Gastrin-17	7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
21.88	Single	8XQF	Apelin-13	8XQF-Apelin-Apelin-13-Gi1/β1/γ2
21.88	Single	8XVE	BQ3020	8XVE-ET_B-BQ3020-chim(Gs-CtGq)/β1/γ2
21.74	Single	4QIM	ANTA XV	4QIM-SMO-ANTA XV
21.74	Single	7LCK	Danuglipron	7LCK-GLP-1-Danuglipron
21.74	Single	7S15	PubChem 134611223	7S15-GLP-1-PubChem 134611223
21.74	Single	8RW7	StilSwitch1	8RW7-A_2A-StilSwitch1-Na
21.74	Single	8RWX	StilSwitch3	8RWX-A_2A-StilSwitch3-Na
21.74	Single	9IMA	Talquetamab	9IMA-GPRC5D-Talquetamab
21.74	Consensus	nucleotide_offon	Orthosteric Ligand	nucleotide_off nucleotide_on
21.74	Consensus	nucleotide_offon_gp	Orthosteric Ligand	nucleotide_on_gp nucleotide_off
21.43	Single	7F8X	NN9056	7F8X-CCK_A-NN9056
21.43	Single	7L0R	Neurotensin	7L0R-NTS₁-Neurotensin-Gi1/β1/γ1
21.43	Single	7WIC	Somatostatin-14	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2
21.43	Single	8XGM	Chemerin	8XGM-CML2-Chemerin-Gi1/β1/γ2
21.43	Single	9BKJ	Cholecystokinin-8	9BKJ-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43	Consensus	cxcr4_on	Orthosteric Ligand	8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
21.43	Consensus	sst5_on	Orthosteric Ligand	8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
21.21	Single	7EIB	Des-Arg10-Kallidin	7EIB-BK₁-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
21.21	Single	7YOO	Neuropeptide-Y	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
21.21	Single	8XWP	Endothelin-1	8XWP-ET_B-Endothelin-1-Gi1/β1/γ2
21.21	Single	8ZJG	Chemerin	8ZJG-CML1-Chemerin-Gi1/β1/γ2
21.21	Consensus	gq_peptide	Orthosteric Ligand	gq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
21.21	Consensus	npy2_on	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
21.21	Consensus	npy2_on_gp	Orthosteric Ligand	7YOO-Y₂-Neuropeptide-Y-Gi1/β1/γ2
21.21	Consensus	peptide_on	Orthosteric Ligand	cck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
21.21	Consensus	peptide_on_gp	Orthosteric Ligand	cck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
20.83	Single	4JKV	Taladegib	4JKV-SMO-Taladegib
20.83	Single	6D26	Fevipiprant	6D26-DP₂-Fevipiprant
20.83	Single	7BB7	AVP	7BB7-V₂-AVP-Gs/β1/γ2
20.83	Single	7Y26	Octreotide	7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.83	Consensus	dp2_off	Orthosteric Ligand	6D26-DP₂-Fevipiprant
20.83	Consensus	dp_off	Orthosteric Ligand	dp2_off
20.69	Single	7EZK	Cholecystokinin-8	7EZK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
20.69	Single	7RMI	Substance-P	7RMI-NK₁-Substance-P-chim(Gs-CtGq)/β1/γ2
20.69	Single	8JBH	Substance-P	8JBH-NK₃-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69	Single	8Z7J	Agonistic antibody	8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
20.69	Consensus	cckb_on	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
20.69	Consensus	ghrelin_on	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
20.69	Consensus	ghrelin_on_gp	Orthosteric Ligand	7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
20.69	Consensus	gi_cck	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
20.69	Consensus	tachykinin_on_gp	Orthosteric Ligand	nk1_on_gp nk2_on_gp nk3_on_gp
20.59	Consensus	etb_on	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
20.51	Consensus	mc2_on	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
20.51	Consensus	mc2_on_gp	Orthosteric Ligand	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
20.00	Single	3ZEV	Neurotensin	3ZEV-NTS₁-Neurotensin
20.00	Single	4BV0	Neurotensin	4BV0-NTS₁-Neurotensin
20.00	Single	5GLH	Endothelin-1	5GLH-ET_B-Endothelin-1
20.00	Single	5V56	TC114	5V56-SMO-TC114
20.00	Single	5V57	TC114	5V57-SMO-TC114
20.00	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
20.00	Single	6LW5	WKYMVm	6LW5-FPR2-ALX-WKYMVm
20.00	Single	6Z8N	SRI-9829	6Z8N-NTS₁-SRI-9829
20.00	Single	7PX4	PSB-2113	7PX4-A_2A-PSB-2113
20.00	Single	7XWO	Neurokinin-A	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00	Single	8FMZ	Neurotensin/Neuromedin-N	8FMZ-NTS₁-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00	Single	8FN1	Neurotensin/Neuromedin-N	8FN1-NTS₁-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
20.00	Single	8HQC	C5a anaphylatoxin	8HQC-C5a₁-C5a anaphylatoxin-Go/β1/γ2
20.00	Single	8I9L	C3a anaphylatoxin	8I9L-C3a_B-C3a anaphylatoxin-Go/β1/γ2
20.00	Single	8IHH	LUF6283	8IHH-HCA₂-LUF6283-Gi1/β1/γ2
20.00	Single	8JBG	Neurokinin-B	8JBG-NK₃-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00	Single	8JEF	(3S)-3-hydroxyoctanoic acid	8JEF-HCA₃-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
20.00	Single	8JPS	CCL7	8JPS-ACKR1-CCL7
20.00	Single	8JZP	C5A anaphylatoxin	8JZP-C5a₁-C5A anaphylatoxin-Go/β1/γ2
20.00	Single	8K6N	Pro-neuropeptide-Y	8K6N-Y₂-Pro-neuropeptide-Y-Gi2/β1/γ1
20.00	Single	8XIP	Pasireotide	8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.00	Single	8XIR	Pasireotide	8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.00	Consensus	cckb_on_gp	Orthosteric Ligand	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCK_B-Gastrin-17-Gi2/β1/γ2
20.00	Consensus	gi_endothelin	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
20.00	Consensus	gi_somatostatin	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
20.00	Consensus	neurotensin_on	Orthosteric Ligand	nts1_on
20.00	Consensus	nk2_on_gp	Orthosteric Ligand	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00	Consensus	nts1_on	Orthosteric Ligand	6OSA-NTS₁-JMV449-Gi1/β1/γ2 7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
20.00	Consensus	protein_off	Orthosteric Ligand	chemokine_off grh_off
20.00	Consensus	somatostatin_on	Orthosteric Ligand	sst2_on sst4_on sst5_on
20.00	Consensus	somatostatin_on_gp	Orthosteric Ligand	sst2_on_gp sst4_on_gp sst5_on_gp
19.44	Single	8HBD	IRL1620	8HBD-ET_B-IRL1620-Gi1/β1/γ2
19.44	Consensus	etb_on_gp	Orthosteric Ligand	8IY5-ET_B-Endothelin-1-Gi1/β1/γ2 8HBD-ET_B-IRL1620-Gi1/β1/γ2
19.35	Single	7W57	Neuromedin-S	7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
19.35	Single	7YON	Peptide-YY(3-36)	7YON-Y₂-Peptide-YY(3-36)-Gi1/β1/γ2
19.35	Single	8XWQ	Endothelin-1	8XWQ-ET_B-Endothelin-1-Gi1/β1/γ2
19.35	Consensus	apelin_on	Orthosteric Ligand	8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
19.35	Consensus	apelin_on_gp	Orthosteric Ligand	8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
19.35	Consensus	gi_class-a	Orthosteric Ligand	gi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
19.35	Consensus	gi_formylpeptide	Orthosteric Ligand	7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
19.35	Consensus	tachykinin_on	Orthosteric Ligand	nk1_on nk2_on nk3_on
19.23	Single	6OS0	Angiotensinogen	6OS0-AT₁-Angiotensinogen
19.23	Single	7Y66	BM213	7Y66-C5a₁-BM213-Gi1/β1/γ2
19.23	Single	8IYW	GSK256073	8IYW-HCA₂-GSK256073-Go/β1/γ2
19.23	Single	8JJP	Chemerin	8JJP-CML2-Chemerin-Gi1/β1/γ2
19.23	Single	8W1V	PubChem 171716265	8W1V-β₂-PubChem 171716265
19.23	Single	8X8N	Octreotide	8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
19.23	Consensus	c3a_on	Orthosteric Ligand	8HK2-C3a_B-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3a_B-E7 peptide-Gi1/β1/γ2
19.23	Consensus	gi_lipid	Orthosteric Ligand	gi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
19.23	Consensus	lipid_offon	Orthosteric Ligand	lipid_off lipid_on
19.23	Consensus	lipid_offon_gp	Orthosteric Ligand	lipid_on_gp lipid_off
19.05	Single	4O9R	Cyclopamine	4O9R-SMO-Cyclopamine
19.05	Single	8JIL	Niacin	8JIL-HCA₂-Niacin-Gi1/β1/γ2
19.05	Single	8U4R	REGN7663-Fab	8U4R-CXCR4-REGN7663-Fab-Cholesterol
18.92	Consensus	gs_peptide	Orthosteric Ligand	gs_cck gs_melanocortin gs_vasop-oxy
18.75	Single	7P02	Protachykinin-1	7P02-NK₁-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
18.75	Single	7X9B	Neuropeptide-Y	7X9B-Y₂-Neuropeptide-Y-Gi1/β1/γ2
18.75	Single	8WWK	MCH	8WWK-MCH1-MCH-Gi1/β1/γ2
18.75	Single	8XQE	Apelin-13	8XQE-Apelin-Apelin-13-Gi1/β1/γ2
18.75	Single	8ZPS	PrRP20	8ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75	Single	8ZRT	ET-1	8ZRT-ET_B-ET-1
18.75	Consensus	cml1_on_gp	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
18.75	Consensus	sst5_on_gp	Orthosteric Ligand	8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
18.52	Single	4BUO	Neurotensin	4BUO-NTS₁-Neurotensin
18.52	Single	7EZH	Cholecystokinin-8	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
18.52	Single	7P00	Substance-P	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52	Single	7X8R	BOC5	7X8R-GLP-1-BOC5-Gs/β1/γ2
18.52	Single	8I95	EP54	8I95-C3a_B-EP54-Go/β1/γ2
18.52	Single	9GE3	Lysophosphatidylinositol	9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
18.52	Consensus	c3a_on_gp	Orthosteric Ligand	8HK2-C3a_B-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3a_B-E7 peptide-Gi1/β1/γ2
18.52	Consensus	cck_on	Orthosteric Ligand	ccka_on cckb_on
18.52	Consensus	cck_on_gp	Orthosteric Ligand	ccka_on_gp cckb_on_gp
18.52	Consensus	ccka_on	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
18.52	Consensus	ccka_on_gp	Orthosteric Ligand	7EZH-CCK_A-Cholecystokinin-8-Gi1/β1/γ2
18.52	Consensus	class-a_on	Orthosteric Ligand	sensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
18.52	Consensus	nk1_on	Orthosteric Ligand	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52	Consensus	nk1_on_gp	Orthosteric Ligand	7P00-NK₁-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52	Consensus	nk2_on	Orthosteric Ligand	7XWO-NK₂-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18	Single	3PWH	ZM-241385	3PWH-A_2A-ZM-241385
18.18	Single	4QIN	SAG1.5	4QIN-SMO-SAG1.5
18.18	Single	6FJ3	PTH	6FJ3-PTH1-PTH
18.18	Single	6O3C	SAG21k	6O3C-SMO-SAG21k-Cholesterol
18.18	Single	7VV5	C48/80	7VV5-MRGPRX2-C48/80-Gi1/β1/γ2
18.18	Single	7YKD	Chemerin-9	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
18.18	Single	8GNG	Istradefylline	8GNG-A_2A-Istradefylline
18.18	Single	8H0P	NMB30	8H0P-BB₁-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18	Single	8H8J	Lodoxamide	8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
18.18	Single	8J6L	Niacin	8J6L-HCA₂-Niacin-Gi1/β1/γ2
18.18	Single	8RW0	Istradefylline	8RW0-A_2A-Istradefylline-Na
18.18	Single	8RW4	AzoSwitch2	8RW4-A_2A-AzoSwitch2-Na
18.18	Single	8RWE	StilSwitch4	8RWE-A_2A-StilSwitch4-Na
18.18	Single	9FUP	Istradefylline	9FUP-A_2A-Istradefylline-Na
17.86	Single	6OMM	WKYMVX	6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
17.86	Single	7F9Z	GHRP-6	7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86	Single	7T11	Octreotide	7T11-SST2-Octreotide-Gi3/β1/γ2
17.86	Single	7X8S	WB4-24	7X8S-GLP-1-WB4-24-Gs/β1/γ2
17.86	Single	7YJ4	INSL5	7YJ4-RXFP4-INSL5-Gi2/β1/γ2
17.86	Single	8JBF	Senktide	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86	Single	9ITB	LPA	9ITB-LPA₆-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86	Consensus	nmur1_on	Orthosteric Ligand	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86	Consensus	sst2_on	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
17.86	Consensus	sst2_on_gp	Orthosteric Ligand	7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
17.78	Single	8GY7	Corticotropin	8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
17.65	Single	7XAT	Somatostatin-14	7XAT-SST2-Somatostatin-14-Gi1/β1/γ2
17.65	Single	9K26	PrRP31	9K26-PrRP-PrRP31-Gi1/β1/γ2
17.39	Single	3REY	XAC	3REY-A_2A-XAC
17.39	Single	6MH8	ZM-241385	6MH8-A_2A-ZM-241385
17.39	Single	7ARO	LUF5833	7ARO-A_2A-LUF5833-Na
17.39	Single	7F61	PF-03654746	7F61-H₃-PF-03654746-Cholesterol
17.39	Single	7VV6	C48/80	7VV6-MRGPRX2-C48/80
17.39	Single	7ZI0	SAG	7ZI0-SMO-SAG-Cholesterol
17.39	Single	8JEI	3-nitro-4-(propylamino)benzoic acid	8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
17.39	Single	8JER	Acipimox	8JER-HCA₂-Acipimox-Go/β1/γ2
17.24	Single	7W0P	Elabela	7W0P-Apelin-Elabela-Gi1/β1/γ2
17.24	Single	7W53	Neuromedin-U-25	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24	Single	7W56	Neuromedin-S	7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24	Single	8GHV	AMG315	8GHV-CB₁-AMG315-Gi1/β1/γ2
17.24	Single	8WDT	photoNECA	8WDT-A_2A-photoNECA
17.24	Single	9L3Y	Retinoic acid receptor responder protein 2	9L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
17.24	Consensus	chemerin_on_gp	Orthosteric Ligand	cml1_on_gp
17.24	Consensus	class-a_on_gp	Orthosteric Ligand	sensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
17.24	Consensus	cml1_on	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
17.24	Consensus	gi_chemerin	Orthosteric Ligand	7YKD-CML1-Chemerin-9-Gi1/β1/γ2
17.24	Consensus	lpl_on	Orthosteric Ligand	s1p_on lpa_on
17.24	Consensus	lpl_on_gp	Orthosteric Ligand	s1p_on_gp lpa_on_gp
17.24	Consensus	nk3_on	Orthosteric Ligand	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24	Consensus	nk3_on_gp	Orthosteric Ligand	8JBF-NK₃-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24	Consensus	nmur1_on_gp	Orthosteric Ligand	7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24	Consensus	nop_on	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/β1/γ2
17.24	Consensus	nop_on_gp	Orthosteric Ligand	8F7X-NOP-Nociceptin-Gi1/β1/γ2
17.14	Single	5VAI	GLP-1	5VAI-GLP-1-GLP-1-Gs/β1/γ2
17.14	Single	7VGX	Neuropeptide-Y	7VGX-Y₁-Neuropeptide-Y-Gi1/β1/γ2
17.14	Consensus	gs_melanocortin	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2 8GY7-MC₂-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2
16.67	Single	5NDD	AZ8838; Na	5NDD-PAR2-AZ8838; Na
16.67	Single	5T04	Neurotensin	5T04-NTS₁-Neurotensin
16.67	Single	5UIG	Cmpd-1	5UIG-A_2A-Cmpd-1
16.67	Single	6LPJ	ZM-241385	6LPJ-A_2A-ZM-241385-Na
16.67	Single	6LPK	ZM-241385	6LPK-A_2A-ZM-241385-Na
16.67	Single	6ORV	TT-OAD2	6ORV-GLP-1-TT-OAD2-Gs/β1/γ2
16.67	Single	6X1A	Danuglipron	6X1A-GLP-1-Danuglipron-Gs/β1/γ2
16.67	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
16.67	Single	6Z4V	NTS8-13	6Z4V-NTS₁-NTS8-13
16.67	Single	7LCI	Danuglipron	7LCI-GLP-1-Danuglipron-Gs/β1/γ2
16.67	Single	7NA8	PubChem 178024	7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
16.67	Single	7PIV	Setmelanotide	7PIV-MC₄-Setmelanotide-Gs/β1/γ2
16.67	Single	7WJ5	Somatostatin-14	7WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
16.67	Single	7XMS	Somatostatin-14	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2
16.67	Single	7YU4	ONO-0740556	7YU4-LPA₁-ONO-0740556
16.67	Single	8F7W	Dynorphin	8F7W-κ-Dynorphin-Gi1/β1/γ2
16.67	Single	8IHJ	Acifran	8IHJ-HCA₃-Acifran-Gi1/β1/γ2
16.67	Single	8JHN	MMF	8JHN-HCA₂-MMF-Go/β1/γ2
16.67	Single	8JII	Niacin	8JII-HCA₂-Niacin-Compound 9n-Gi1/β1/γ2
16.67	Single	8JZZ	C5a-desArg	8JZZ-C5a₁-C5a-desArg-Go/β1/γ2
16.67	Single	8SG1	Chemerin-9	8SG1-CML1-Chemerin-9-Gi1/β1/γ2
16.67	Single	8XYD	Platelet Activating Factor	8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
16.67	Single	8ZBE	Octreotide	8ZBE-SST5-Octreotide-Gi1/β1/γ1
16.67	Consensus	lipid_off	Orthosteric Ligand	cannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
16.22	Consensus	melanocortin_on	Orthosteric Ligand	mc1_on mc4_on mc2_on mc3_on mc5_on
16.22	Consensus	melanocortin_on_gp	Orthosteric Ligand	mc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
16.13	Single	7MBX	Cholecystokinin-8	7MBX-CCK_A-Cholecystokinin-8-Gs/β1/γ1
16.13	Single	7RYC	Oxytocin	7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.13	Single	7XOU	Cholecystokinin-8	7XOU-CCK_A-Cholecystokinin-8-Gs/β1/γ2
16.13	Single	8WKZ	SBL-MC-31	8WKZ-MC₄-SBL-MC-31
16.13	Single	8XZG	Apelin-13	8XZG-Apelin-Apelin-13-Gi1/β1/γ2
16.13	Single	9K27	PrRP31	9K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
16.13	Consensus	fpr2-alx_on	Orthosteric Ligand	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
16.13	Consensus	gs_cck	Orthosteric Ligand	7MBX-CCK_A-Cholecystokinin-8-Gs/β1/γ1
16.00	Single	5IUA	Q27456348	5IUA-A_2A-Q27456348-Na
16.00	Single	6LPL	ZM-241385	6LPL-A_2A-ZM-241385-Na
16.00	Single	6S0Q	ZM-241385	6S0Q-A_2A-ZM-241385
16.00	Single	6WQA	ZM-241385	6WQA-A_2A-ZM-241385-Na
16.00	Single	6XBK	Cholesterol	6XBK-SMO-Cholesterol-Gi1/β1/γ2
16.00	Single	7RM5	ZM-241385	7RM5-A_2A-ZM-241385-Na
16.00	Single	7VV4	Cortistatin-14	7VV4-MRGPRX2-Cortistatin-14
16.00	Single	7YU3	ONO-0740556	7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
16.00	Single	7YU6	ONO-0740556	7YU6-LPA₁-ONO-0740556-Gi1/β1/γ2
16.00	Single	8FYN	ZM-241385	8FYN-A_2A-ZM-241385-Na
16.00	Single	8UUJ	FCH-2296413	8UUJ-HCA₂-FCH-2296413-Gi1/β1/γ2
16.00	Single	8ZPT	PrRP20	8ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00	Single	9IYB	Prostaglandin	9IYB-DP₂-Prostaglandin-A1D5Q-Gi1/β1/γ2
16.00	Consensus	lipid_on	Orthosteric Ligand	cannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
16.00	Consensus	lipid_on_gp	Orthosteric Ligand	cannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
15.79	Single	7V68	PubChem 57664406	7V68-M₄-Iperoxo-PubChem 57664406-Gi1/β1/γ2
15.79	Single	9JR2	PTH	9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.62	Single	6M1I	PACAP	6M1I-PAC₁-PACAP-Gs/β1/γ2
15.62	Single	7DW9	AVP	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
15.62	Single	7KH0	AVP	7KH0-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
15.62	Single	7T10	Somatostatin-14	7T10-SST2-Somatostatin-14-Gi3/β1/γ2
15.62	Single	7XK8	Neuromedin-U-25	7XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
15.62	Consensus	cxcr3_on_gp	Orthosteric Ligand	8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
15.62	Consensus	fpr2-alx_on_gp	Orthosteric Ligand	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
15.62	Consensus	gs_vasop-oxy	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
15.62	Consensus	peptide_offon_gp	Orthosteric Ligand	peptide_on_gp peptide_off
15.62	Consensus	v2_on	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
15.62	Consensus	v2_on_gp	Orthosteric Ligand	7DW9-V₂-AVP-chim(NtGi1-Gs)/β1/γ2
15.62	Consensus	vasop-oxy_on	Orthosteric Ligand	v2_on
15.62	Consensus	vasop-oxy_on_gp	Orthosteric Ligand	v2_on_gp
15.38	Single	4IAQ	Dihydroergotamine	4IAQ-5-HT_1B-Dihydroergotamine
15.38	Single	7M8W	15r-Methyl-Prostaglandin D2	7M8W-DP₂-15r-Methyl-Prostaglandin D2-Na
15.38	Single	7R0C	AVP	7R0C-V₂-AVP-Arrestin2
15.38	Single	7XOW	Gastrin	7XOW-CCK_B-Gastrin-chim(NtGi1-Gq)/β1/γ2
15.38	Single	7Y24	Octreotide	7Y24-SST2-Octreotide-Go/β1/γ2
15.38	Single	7YU5	ONO-0740556	7YU5-LPA₁-ONO-0740556-Gi1/β1/γ2
15.38	Single	7YU7	ONO-0740556	7YU7-LPA₁-ONO-0740556-Gi1/β1/γ2
15.38	Single	8HPT	C5a anaphylatoxin C-terminal peptide	8HPT-C5a₁-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
15.38	Single	8ID6	Oleic acid	8ID6-FFA4-Oleic acid-Gi1/β1/γ2
15.38	Single	8IHB	GSK256073	8IHB-HCA₂-GSK256073-Gi1/β1/γ2
15.38	Single	8JSR	Anamorelin	8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38	Single	9ITE	LPA	9ITE-LPA₆-LPA-chim(NtGi2-G13)/β1/γ2
15.38	Single	9IZG	NKP	9IZG-LPA₁-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38	Consensus	ffa2_on	Orthosteric Ligand	8J22-FFA2-TUG-1375-Gi1/β1/γ2
15.38	Consensus	gi_lpa	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
15.38	Consensus	lpa_on	Orthosteric Ligand	lpa1_on
15.38	Consensus	lpa_on_gp	Orthosteric Ligand	lpa1_on_gp
15.15	Single	5YQZ	Glucagon analogue	5YQZ-Glucagon-Glucagon analogue
15.15	Single	7Y35	Abaloparatide	7Y35-PTH1-Abaloparatide-Gs/β1/γ2
15.15	Single	8XGO	TAK448	8XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
15.15	Consensus	opioid_on	Orthosteric Ligand	mop_on nop_on dop_on kop_on
14.81	Single	3VW7	Vorapaxar; Na	3VW7-PAR1-Vorapaxar; Na
14.81	Single	4PXZ	2MeSADP	4PXZ-P2Y₁₂-2MeSADP
14.81	Single	4PY0	2MeSATP	4PY0-P2Y₁₂-2MeSATP
14.81	Single	6KPG	AM841	6KPG-CB₁-AM841-Gi1/β1/γ2
14.81	Single	7BZ2	Arformoterol	7BZ2-β₂-Arformoterol-Gs/β1/γ2
14.81	Single	7DH5	Mirabegron	7DH5-β₃-Mirabegron-Gs/β1/γ2
14.81	Single	7L0S	Neurotensin	7L0S-NTS₁-Neurotensin-Gi1/β1/γ1
14.81	Single	7L1U	Orexin	7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81	Single	7XZ5	Lysophosphatidylcholine	7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
14.81	Single	8DWC	Proenkephalin-A	8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.81	Single	8H0Q	Gastrin Releasing Peptide	8H0Q-BB₂-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81	Single	8JJL	Olodaterol	8JJL-β₂-Olodaterol
14.81	Single	8JWY	2-118	8JWY-A_2A-2-118
14.81	Single	9L3W	Retinoic acid receptor responder protein 2	9L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
14.81	Consensus	ffa2_on_gp	Orthosteric Ligand	8J22-FFA2-TUG-1375-Gi1/β1/γ2
14.81	Consensus	lpa1_off	Orthosteric Ligand	4Z36-LPA₁-ONO-3080573 4Z35-LPA₁-ONO-9910539 4Z34-LPA₁-ONO-9780307
14.81	Consensus	lpa_off	Orthosteric Ligand	lpa1_off
14.81	Consensus	lpl_off	Orthosteric Ligand	s1p_off lpa_off
14.71	Consensus	opioid_on_gp	Orthosteric Ligand	mop_on_gp nop_on_gp dop_on_gp kop_on_gp
14.29	Single	3OE6	IT1t	3OE6-CXCR4-IT1t
14.29	Single	4NC3	Ergotamine	4NC3-5-HT_2B-Ergotamine
14.29	Single	4Z35	ONO-9910539	4Z35-LPA₁-ONO-9910539
14.29	Single	5TUD	Ergotamine	5TUD-5-HT_2B-Ergotamine
14.29	Single	6BQG	Ergotamine	6BQG-5-HT_2C-Ergotamine
14.29	Single	6M1H	Maxadilan	6M1H-PAC₁-Maxadilan-Gs/β1/γ2
14.29	Single	7EZC	UKA	7EZC-A_2A-UKA
14.29	Single	7MBY	Cholecystokinin-8	7MBY-CCK_A-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29	Single	7V6A	-	7V6A-M₄-PubChem 9864275-Gi1/β1/γ2
14.29	Single	7WVY	Amyloid-Beta42	7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
14.29	Single	7XJI	Solabegron	7XJI-β₃-Solabegron-Gs/β1/γ2
14.29	Single	7Y65	C5a peptide	7Y65-C5a₁-C5a peptide-Gi1/β1/γ2
14.29	Single	7YU8	ONO-0740556	7YU8-LPA₁-ONO-0740556-Gi1/β1/γ2
14.29	Single	8FU6	Glucagon derivative ZP3780	8FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
14.29	Single	8HAO	PTH	8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
14.29	Single	8IYS	TUG-891	8IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
14.29	Single	8JRV	Glucagon	8JRV-Glucagon-Glucagon-Arrestin2
14.29	Single	8K2X	CXCL10	8K2X-CXCR3-CXCL10-Gi1/β1/γ2
14.29	Single	8WRZ	PubChem 102336704	8WRZ-CB₁-PubChem 102336704-Arrestin2
14.29	Single	8XBE	S3E-LysoPS	8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
14.29	Single	8ZH8	QRF-Amide	8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
14.29	Consensus	chemerin_on	Orthosteric Ligand	cml1_on
14.29	Consensus	nucleotide_on_gp	Orthosteric Ligand	adenosine_on_gp p2y_on_gp
13.89	Single	6NBH	Long-Acting PTH Analog	6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
13.89	Single	7VVJ	PTHrP(1-36)	7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
13.89	Single	7VVL	PTH	7VVL-PTH1-PTH-Gs/β1/γ2
13.79	Single	5WF6	UK-432097	5WF6-A_2A-UK-432097
13.79	Single	6RZ6	ONO-2570366	6RZ6-CysLT₂-ONO-2570366
13.79	Single	7F8W	Gastrin-17	7F8W-CCK_B-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
13.79	Single	7S8L	Cortistatin-14	7S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.79	Single	7XN9	L-054,522	7XN9-SST2-L-054,522
13.79	Single	7XY6	BAY 60-6583	7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
13.79	Single	8F7R	Endomorphin	8F7R-μ-Endomorphin-Gi1/β1/γ2
13.79	Single	8H4I	Doconexent	8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
13.79	Single	8J22	TUG-1375	8J22-FFA2-TUG-1375-Gi1/β1/γ2
13.79	Single	8QJ2	pN162	8QJ2-MC₄-pN162-Gs
13.79	Single	9ERX	D9-THC analog	9ERX-CB₁-D9-THC analog-Gi1/β1/γ2
13.79	Consensus	formylpeptide_on	Orthosteric Ligand	fpr2-alx_on fpr1-alx_on
13.64	Single	3OE9	IT1t	3OE9-CXCR4-IT1t
13.64	Single	5L7I	Vismodegib	5L7I-SMO-Vismodegib
13.64	Single	6LI0	C17	6LI0-GPR52-C17
13.64	Single	7S8N	R-Zinc-3573	7S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.64	Single	7S8O	R-Zinc-3573	7S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
13.64	Single	8IHI	Acifran	8IHI-HCA₂-Acifran-Gi1/β1/γ2
13.64	Single	8RWH	StilSwitch2	8RWH-A_2A-StilSwitch2-Na
13.64	Single	8ZX5	AM251	8ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
13.33	Single	4IAR	Ergotamine	4IAR-5-HT_1B-Ergotamine
13.33	Single	4IB4	Ergotamine	4IB4-5-HT_2B-Ergotamine
13.33	Single	7F54	Afamelanotide	7F54-MC₄-Afamelanotide-Gs/β1/γ2
13.33	Single	7WVW	fMYFINILTL	7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
13.33	Single	7XAU	Octreotide	7XAU-SST2-Octreotide-Gi1/β1/γ2
13.33	Single	8DWG	Proenkephalin-A	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.33	Single	8F7X	Nociceptin	8F7X-NOP-Nociceptin-Gi1/β1/γ2
13.33	Single	8WZ2	Orexigenic Neuropeptide QRFP	8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.33	Single	8ZCJ	Pasireotide	8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
13.33	Single	8ZSP	LSD	8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.33	Consensus	gi_nucleotide	Orthosteric Ligand	gi_adenosine gi_p2y
13.33	Consensus	gi_opioid	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
13.33	Consensus	mc4_on	Orthosteric Ligand	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2
13.04	Single	3ODU	IT1t	3ODU-CXCR4-IT1t
13.04	Single	3VG9	ZM-241385	3VG9-A_2A-ZM-241385-Antibody
13.04	Single	5ZKQ	ABT-491	5ZKQ-PAF-ABT-491
13.04	Single	6ZA8	RTI-3a	6ZA8-NTS₁-RTI-3a
13.04	Single	7LCJ	Danuglipron	7LCJ-GLP-1-Danuglipron
13.04	Single	8HMP	C17	8HMP-GPR52-C17-Gs/β1/γ2
13.04	Single	8IJB	Acipimox	8IJB-HCA₂-Acipimox-Gi1/β1/γ2
13.04	Single	8RVW	StilSwitch3	8RVW-A_2A-StilSwitch3-Na
13.04	Single	8U4P	AMD3100	8U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
13.04	Single	8UTD	MK1903	8UTD-HCA₂-MK1903-Gi1/β1/γ2
13.04	Single	9BA0	A1AKN	9BA0-CB₁-A1AKN
13.04	Consensus	paf_off	Orthosteric Ligand	5ZKQ-PAF-ABT-491
12.90	Single	3QAK	UK-432097	3QAK-A_2A-UK-432097
12.90	Single	6WHC	Glu16 analog of GCG	6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
12.90	Single	7TRY	Urocortin	7TRY-CRF₂-Urocortin-chim(NtGi1-G11)/β1/γ2
12.90	Single	8F7Q	Beta-Endorphin	8F7Q-μ-β-Endorphin-Gi1/β1/γ2
12.90	Single	8F7S	Deltorphin	8F7S-δ-Deltorphin-Gi1/β1/γ2
12.90	Consensus	dop_on_gp	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/β1/γ2
12.90	Consensus	formylpeptide_on_gp	Orthosteric Ligand	fpr2-alx_on_gp fpr1-alx_on_gp
12.90	Consensus	mc4_on_gp	Orthosteric Ligand	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC₄-THIQ-Gs/β1/γ2 7F54-MC₄-Afamelanotide-Gs/β1/γ2 7F53-MC₄-α-MSH-Gs/β1/γ2 7F55-MC₄-Bremelanotide-Gs/β1/γ2
12.90	Consensus	mc5_on	Orthosteric Ligand	8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
12.90	Consensus	sst4_on	Orthosteric Ligand	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
12.90	Consensus	sst4_on_gp	Orthosteric Ligand	7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
12.82	Single	6WPW	Glucagon derivative ZP3780	6WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
12.50	Single	3V2Y	PubChem 51892645	3V2Y-S1P₁-PubChem 51892645
12.50	Single	5IU4	ZM-241385	5IU4-A_2A-ZM-241385-Na
12.50	Single	5IUB	Q27456344	5IUB-A_2A-Q27456344-Na
12.50	Single	5K2B	ZM-241385	5K2B-A_2A-ZM-241385-Na
12.50	Single	5K2C	ZM-241385	5K2C-A_2A-ZM-241385-Na
12.50	Single	5NLX	ZM-241385	5NLX-A_2A-ZM-241385-Na
12.50	Single	5NM4	ZM-241385	5NM4-A_2A-ZM-241385-Na
12.50	Single	5UVI	ZM-241385	5UVI-A_2A-ZM-241385
12.50	Single	5WF5	UK-432097	5WF5-A_2A-UK-432097
12.50	Single	6AQF	ZM-241385	6AQF-A_2A-ZM-241385
12.50	Single	6PT0	WIN 55212-2	6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2
12.50	Single	6VN7	PACAP	6VN7-VPAC₁-PACAP-Gs/β1/γ2
12.50	Single	6XBL	SAG	6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
12.50	Single	6ZIN	SR48692	6ZIN-NTS₁-SR48692
12.50	Single	7F4D	Alpha-MSH	7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2
12.50	Single	7T32	ZM-241385	7T32-A_2A-ZM-241385
12.50	Single	7TD0	LPA	7TD0-LPA₁-LPA-Gi1/β1/γ2
12.50	Single	7TD2	LPA	7TD2-LPA₁-LPA-Gi1/β1/γ2
12.50	Single	7UTZ	PubChem 644078	7UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
12.50	Single	7YK6	PubChem 138319674	7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
12.50	Single	8FLQ	PTH	8FLQ-PTH1-PTH-Gs/β1/γ2
12.50	Single	8GUR	CP55,940	8GUR-CB₂-CP55,940-Gi1/β1/γ2
12.50	Single	8IHK	Acifran	8IHK-HCA₃-Acifran
12.50	Single	8IY9	Niacin	8IY9-HCA₂-Niacin-Go/β1/γ2
12.50	Single	8JIM	MMF	8JIM-HCA₂-MMF-Gi1/β1/γ2
12.50	Single	8K5C	Acipimox	8K5C-HCA₂-Acipimox
12.50	Single	8RWC	StilSwitch2	8RWC-A_2A-StilSwitch2-Na
12.50	Single	8RWD	StilSwitch3	8RWD-A_2A-StilSwitch3-Na
12.50	Single	8ZPN	AMD3100	8ZPN-CXCR4-AMD3100-Cholesterol
12.50	Single	9IVM	GLP-1 (Truncated)	9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
12.50	Consensus	gs_class-a	Orthosteric Ligand	gs_peptide gs_nucleotide gs_amine
12.50	Consensus	hca_on	Orthosteric Ligand	hca2_on
12.50	Consensus	peptide_offon	Orthosteric Ligand	peptide_off peptide_on
12.12	Single	6WI9	Secretin	6WI9-Secretin-Secretin-Gs/β1/γ2
12.12	Single	7F4H	Afamelanotide	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
12.12	Single	7FIM	Tirzepatide	7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
12.12	Single	7V9M	Somatoliberin	7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
12.12	Single	7W40	Bombesin	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2
12.12	Single	8H4K	GW9508	8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12	Single	8HA0	PTH	8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
12.12	Single	8J6I	MK6892	8J6I-HCA₂-MK6892-Gi1/β1/γ2
12.12	Single	9BKK	Cholecystokinin-8	9BKK-CCK_A-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12	Consensus	mc5_on_gp	Orthosteric Ligand	8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
12.00	Single	3EML	ZM-241385	3EML-A_2A-ZM-241385
12.00	Single	4EIY	ZM-241385	4EIY-A_2A-ZM-241385-Na
12.00	Single	5IU8	Q27456347	5IU8-A_2A-Q27456347-Na
12.00	Single	5K2A	ZM-241385	5K2A-A_2A-ZM-241385-Na
12.00	Single	5OLG	ZM-241385	5OLG-A_2A-ZM-241385-Na
12.00	Single	5UEN	DU172	5UEN-A₁-DU172
12.00	Single	5VRA	ZM-241385	5VRA-A_2A-ZM-241385-Na
12.00	Single	5ZKP	Foropafant (SR27417)	5ZKP-PAF-Foropafant (SR27417)
12.00	Single	6S0L	ZM-241385	6S0L-A_2A-ZM-241385
12.00	Single	7FIH	Org43553	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
12.00	Single	7PYR	PSB-2115	7PYR-A_2A-PSB-2115
12.00	Single	7V3Z	CP55940	7V3Z-CB₁-CP55940
12.00	Single	7YAC	Paltusotine	7YAC-SST2-Paltusotine-Gi1/β1/γ2
12.00	Single	8CU6	LJ-4517	8CU6-A_2A-LJ-4517
12.00	Single	8EFQ	Damgo	8EFQ-μ-Damgo-Gi1/β1/γ2
12.00	Single	8I7V	Acipimox	8I7V-HCA₂-Acipimox-Gi1/β1/γ2
12.00	Single	8J6P	Niacin	8J6P-HCA₂-Niacin-Compound 9n-Gi1/β1/γ2
12.00	Single	8K5D	GSK256073	8K5D-HCA₂-GSK256073
12.00	Single	8X17	Namodenoson	8X17-A_3A-Namodenoson-Gi1/β1/γ2
12.00	Single	8ZQE	GPR15L(C11)	8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
12.00	Single	9B9Z	A1AKO	9B9Z-CB₁-A1AKO
12.00	Consensus	gi_hca	Orthosteric Ligand	8J6R-HCA₂-MK6892-Gi1/β1/γ2 8JIM-HCA₂-MMF-Gi1/β1/γ2 8IHI-HCA₂-Acifran-Gi1/β1/γ2 8IHH-HCA₂-LUF6283-Gi1/β1/γ2 8I7V-HCA₂-Acipimox-Gi1/β1/γ2 8I7W-HCA₂-GSK256073-Gi1/β1/γ2
12.00	Consensus	hca2_on	Orthosteric Ligand	8J6R-HCA₂-MK6892-Gi1/β1/γ2 8JIM-HCA₂-MMF-Gi1/β1/γ2 8I7V-HCA₂-Acipimox-Gi1/β1/γ2 8I7W-HCA₂-GSK256073-Gi1/β1/γ2 8IHH-HCA₂-LUF6283-Gi1/β1/γ2 8IHI-HCA₂-Acifran-Gi1/β1/γ2
12.00	Consensus	hca2_on_gp	Orthosteric Ligand	8J6R-HCA₂-MK6892-Gi1/β1/γ2 8IHI-HCA₂-Acifran-Gi1/β1/γ2 8IHH-HCA₂-LUF6283-Gi1/β1/γ2 8I7V-HCA₂-Acipimox-Gi1/β1/γ2 8JIM-HCA₂-MMF-Gi1/β1/γ2 8I7W-HCA₂-GSK256073-Gi1/β1/γ2
12.00	Consensus	hca_on_gp	Orthosteric Ligand	hca2_on_gp
11.76	Single	6X18	GLP-1	6X18-GLP-1-GLP-1-Gs/β1/γ2
11.76	Single	7LLY	Oxyntomodulin	7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
11.76	Single	7WBJ	PACAP27	7WBJ-VPAC₁-PACAP27-Gs/β1/γ2
11.76	Single	8E3Y	PACAP27	8E3Y-VPAC₁-PACAP27-Gs/β1/γ2
11.76	Consensus	mc1_on	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
11.76	Consensus	mc1_on_gp	Orthosteric Ligand	7F4H-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC₁-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
11.63	Single	7F16	TIP39	7F16-PTH2-TIP39-Gs/β1/γ2
11.54	Single	5N2R	PSB-36	5N2R-A_2A-PSB-36-Na
11.54	Single	5N2S	PSB36	5N2S-A₁-PSB36
11.54	Single	5NM2	ZM-241385	5NM2-A_2A-ZM-241385-Na
11.54	Single	5YHL	PubChem 135121352	5YHL-EP₄-PubChem 135121352
11.54	Single	5YWY	ONO-AE3-208	5YWY-EP₄-ONO-AE3-208
11.54	Single	6KPC	PubChem 145915889	6KPC-CB₂-PubChem 145915889
11.54	Single	6Z4Q	SR142948A	6Z4Q-NTS₁-SR142948A
11.54	Single	6Z4S	SR48692	6Z4S-NTS₁-SR48692
11.54	Single	7C61	Ergotamine	7C61-5-HT_1B-Ergotamine
11.54	Single	7EO2	FTY720-P	7EO2-S1P₁-FTY720-P-Gi1/β1/γ2
11.54	Single	7TD3	S1P	7TD3-S1P₁-S1P-Gi1/β1/γ2
11.54	Single	8GNE	KW-6356	8GNE-A_2A-KW-6356-Na
11.54	Single	8I7W	GSK256073	8I7W-HCA₂-GSK256073-Gi1/β1/γ2
11.54	Single	8QOT	Nanobody-E	8QOT-μ-Nanobody-E
11.54	Single	8TF5	Oleic acid	8TF5-GPR6-Oleic acid
11.54	Single	9F34	FOB02-04A	9F34-D₃-FOB02-04A-Go1/β1/γ2
11.54	Consensus	a1_off	Orthosteric Ligand	5UEN-A₁-DU172 5N2S-A₁-PSB36
11.54	Consensus	adenosine_off	Orthosteric Ligand	a1_off a2_off
11.54	Consensus	cb2_on	Orthosteric Ligand	8GUR-CB₂-CP55,940-Gi1/β1/γ2 8GUS-CB₂-HU-308-Gi1/β1/γ2 8GUT-CB₂-LEI-102-Gi1/β1/γ2 6KPF-CB₂-PubChem 145915889-Gi1/β1/γ2 6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB₂-Olorinab-Gi1/β1/γ2
11.54	Consensus	cb2_on_gp	Orthosteric Ligand	8GUR-CB₂-CP55,940-Gi1/β1/γ2 8GUS-CB₂-HU-308-Gi1/β1/γ2 8GUT-CB₂-LEI-102-Gi1/β1/γ2 6KPF-CB₂-PubChem 145915889-Gi1/β1/γ2 6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB₂-Olorinab-Gi1/β1/γ2
11.54	Consensus	cyslt_off	Orthosteric Ligand	cyslt2_off cyslt1_off
11.54	Consensus	ep4_off	Orthosteric Ligand	5YWY-EP₄-ONO-AE3-208 5YHL-EP₄-PubChem 135121352
11.54	Consensus	ep_off	Orthosteric Ligand	ep4_off
11.54	Consensus	lpa1_on	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
11.54	Consensus	lpa1_on_gp	Orthosteric Ligand	7TD1-LPA₁-LPA-Gi1/β1/γ2 7YU3-LPA₁-ONO-0740556-Gi1/β1/γ2
11.54	Consensus	nucleotide_on	Orthosteric Ligand	adenosine_on p2y_on
11.54	Consensus	rxfp4_on	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
11.54	Consensus	rxfp4_on_gp	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
11.54	Consensus	s1p5_off	Orthosteric Ligand	7YXA-S1P₅-ONO-5430608
11.54	Consensus	s1p_off	Orthosteric Ligand	s1p1_off s1p5_off
11.43	Single	6NBF	Long-Acting PTH Analog	6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
11.43	Single	6NBI	Long-Acting PTH Analog	6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
11.43	Single	7RA3	GIP	7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
11.43	Single	7RGP	Tirzepatide	7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
11.43	Single	7W3Z	Gastrin Releasing Peptide	7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
11.43	Single	8E3X	PACAP27	8E3X-PAC₁-PACAP27-Gs/β1/γ2
11.43	Single	8JIS	Peptide-15	8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
11.11	Single	4Z34	ONO-9780307	4Z34-LPA₁-ONO-9780307
11.11	Single	5NX2	GLP-1 (Truncated)	5NX2-GLP-1-GLP-1 (Truncated)
11.11	Single	5TZR	MK8666	5TZR-FFA1-MK8666
11.11	Single	5XR8	AM841	5XR8-CB₁-AM841
11.11	Single	5XRA	AM11542	5XRA-CB₁-AM11542
11.11	Single	6B3J	Exendin-P5	6B3J-GLP-1-Exendin-P5-Gs/β1/γ2
11.11	Single	6N4B	MDMB-Fubinaca	6N4B-CB₁-MDMB-Fubinaca-Gi1/β1/γ2
11.11	Single	7E2Z	Aripiprazole	7E2Z-5-HT_1A-Aripiprazole-Gi1/β1/γ2
11.11	Single	7F4F	Afamelanotide	7F4F-MC₁-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
11.11	Single	7F53	Alpha-MSH	7F53-MC₄-α-MSH-Gs/β1/γ2
11.11	Single	7F58	THIQ	7F58-MC₄-THIQ-Gs/β1/γ2
11.11	Single	7FEE	CP55940	7FEE-CB₁-CP55940-ZCZ011
11.11	Single	7FIY	Tirzepatide	7FIY-GIP-Tirzepatide-Gs/β1/γ2
11.11	Single	7S8M	Cortistatin-14	7S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
11.11	Single	7T9N	PubChem 644078	7T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
11.11	Single	7TD1	LPA	7TD1-LPA₁-LPA-Gi1/β1/γ2
11.11	Single	7TUY	GSK682753A	7TUY-GPR183-GSK682753A
11.11	Single	7VIG	CBP-307	7VIG-S1P₁-CBP-307-Gi1/β1/γ2
11.11	Single	7VQX	PACAP27	7VQX-VPAC₁-PACAP27-Gs/β1/γ2
11.11	Single	7VVK	PTH	7VVK-PTH1-PTH-Gs/β1/γ2
11.11	Single	7WV9	CP55940	7WV9-CB₁-CP55940-ZCZ011-Gi2/β1/γ2
11.11	Single	7XAV	Lanreotide	7XAV-SST2-Lanreotide-Gi1/β1/γ2
11.11	Single	7XTQ	R399	7XTQ-GPBA-R399-Gs/β1/γ2
11.11	Single	8FEG	(DNCP)-Beta-Naloxamine	8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
11.11	Single	8GUS	HU-308	8GUS-CB₂-HU-308-Gi1/β1/γ2
11.11	Single	8HDO	BAY 60-6583	8HDO-A_2B-BAY 60-6583-Gs/β1/γ2
11.11	Single	8I2G	Compound 716340	8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
11.11	Single	8ID3	9-Hydroxystearic acid	8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
11.11	Single	8UGW	PubChem 3086599	8UGW-A_2A-PubChem 3086599
11.11	Single	8Y63	C20:0 Ceramide	8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
11.11	Consensus	a2_on	Orthosteric Ligand	a2b_on
11.11	Consensus	a2_on_gp	Orthosteric Ligand	a2b_on_gp
11.11	Consensus	a2b_on	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2
11.11	Consensus	a2b_on_gp	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2
11.11	Consensus	class-a_off	Orthosteric Ligand	sensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
11.11	Consensus	ffa_on	Orthosteric Ligand	ffa2_on ffa3_on
11.11	Consensus	ffa_on_gp	Orthosteric Ligand	ffa2_on_gp ffa3_on_gp
11.11	Consensus	gi_cannabinoid	Orthosteric Ligand	8GUR-CB₂-CP55,940-Gi1/β1/γ2 8GUS-CB₂-HU-308-Gi1/β1/γ2 8GUT-CB₂-LEI-102-Gi1/β1/γ2 8GUQ-CB₂-Olorinab-Gi1/β1/γ2 6KPF-CB₂-PubChem 145915889-Gi1/β1/γ2 6PT0-CB₂-WIN 55212-2-Gi1/β1/γ2 6KPG-CB₁-AM841-Gi1/β1/γ2
11.11	Consensus	gi_ffa	Orthosteric Ligand	8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
11.11	Consensus	gi_relaxin	Orthosteric Ligand	7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
11.11	Consensus	gs_adenosine	Orthosteric Ligand	8HDP-A_2B-Adenosine-Gs/β1/γ2 8HDO-A_2B-BAY 60-6583-Gs/β1/γ2 7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A_2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
11.11	Consensus	gs_nucleotide	Orthosteric Ligand	gs_adenosine
11.11	Consensus	p2y12_on	Orthosteric Ligand	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
11.11	Consensus	relaxin_on	Orthosteric Ligand	rxfp4_on
11.11	Consensus	relaxin_on_gp	Orthosteric Ligand	rxfp4_on_gp
10.81	Single	6LMK	Glucagon	6LMK-Glucagon-Glucagon-Gs/β1/γ2
10.81	Single	6WZG	Secretin	6WZG-Secretin-Secretin-Gs/β1/γ2
10.81	Single	7D68	GLP-2	7D68-GLP-2-GLP-2-Gs/β1/γ2
10.81	Single	7KI1	Taspoglutide	7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
10.81	Single	8HAF	PTHrP(1-36)	8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
10.71	Single	4N4W	SANT-1	4N4W-SMO-SANT-1
10.71	Single	4Z36	ONO-3080573	4Z36-LPA₁-ONO-3080573
10.71	Single	5TZY	MK8666; PubChem 127053597	5TZY-FFA1-MK8666; PubChem 127053597
10.71	Single	6A93	Risperidone	6A93-5-HT_2A-Risperidone
10.71	Single	6KQI	CP55940	6KQI-CB₁-CP55940-Org27569
10.71	Single	6MXT	Salmeterol	6MXT-β₂-Salmeterol
10.71	Single	6RZ7	ONO-2570366	6RZ7-CysLT₂-ONO-2570366
10.71	Single	6XOX	Orforglipron	6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
10.71	Single	7EW2	Fingolimod	7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
10.71	Single	7F55	Bremelanotide	7F55-MC₄-Bremelanotide-Gs/β1/γ2
10.71	Single	7K15	MKD046	7K15-BLT₁-MKD046-Na
10.71	Single	7XW5	ML109	7XW5-TSH-TSH-ML109-Gs/β1/γ2
10.71	Single	7XXI	2MeSADP	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
10.71	Single	8I9A	EP54	8I9A-C3a_B-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
10.71	Single	8IA8	E7 peptide	8IA8-C3a_B-E7 peptide-Gi1/β1/γ2
10.71	Single	8JWZ	AB928	8JWZ-A_2A-AB928-Na
10.71	Single	8T3Q	Docosa-4,7,10,13,16,19-Hexaenoic acid	8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.71	Single	8WRB	Lysophosphatidylserine	8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
10.71	Single	9IZH	LPA	9IZH-LPA₁-LPA-chim(NtGi2-G13)/β1/γ2
10.71	Consensus	5ht1a_on	Orthosteric Ligand	8FYT-5-HT_1A-LSD-Gi1/β1/γ1 7E2Y-5-HT_1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT_1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT_1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT_1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT_1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT_1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT_1A-Vilazodone-Gi1/β1/γ1
10.71	Consensus	5ht1a_on_gp	Orthosteric Ligand	8FYT-5-HT_1A-LSD-Gi1/β1/γ1 8FYX-5-HT_1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT_1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT_1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT_1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT_1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT_1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT_1A-Vilazodone-Gi1/β1/γ1
10.71	Consensus	beta3_on	Orthosteric Ligand	7DH5-β₃-Mirabegron-Gs/β1/γ2 7XJH-β₃-Isoproterenol-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2
10.71	Consensus	beta3_on_gp	Orthosteric Ligand	7DH5-β₃-Mirabegron-Gs/β1/γ2 7XJH-β₃-Isoproterenol-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2
10.71	Consensus	cannabinoid_off	Orthosteric Ligand	cb2_off cb1_off
10.71	Consensus	cannabinoid_on	Orthosteric Ligand	cb2_on cb1_on
10.71	Consensus	cannabinoid_on_gp	Orthosteric Ligand	cb2_on_gp cb1_on_gp
10.71	Consensus	cb1_on	Orthosteric Ligand	6KPG-CB₁-AM841-Gi1/β1/γ2 8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
10.71	Consensus	gi_muscarinic	Orthosteric Ligand	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M₂-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2
10.71	Consensus	gi_p2y	Orthosteric Ligand	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
10.71	Consensus	m4_on	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2
10.71	Consensus	m4_on_gp	Orthosteric Ligand	7TRS-M₄-Acetylcholine-Gi1/β1/γ2 7V6A-M₄-PubChem 9864275-Gi1/β1/γ2 8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M₄-Iperoxo-Gi1/β1/γ2
10.71	Consensus	p2y12_on_gp	Orthosteric Ligand	7XXI-P2Y₁₂-2MeSADP-Gi2/β1/γ2
10.71	Consensus	s1p1_on	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
10.71	Consensus	s1p1_on_gp	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
10.53	Single	7DUQ	GLP-1	7DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
10.53	Single	8ZJE	TAK-448	8ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
10.53	Consensus	bb2_on	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
10.53	Consensus	bb2_on_gp	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
10.53	Consensus	bombesin_on	Orthosteric Ligand	bb2_on
10.53	Consensus	bombesin_on_gp	Orthosteric Ligand	bb2_on_gp
10.53	Consensus	gq_bombesin	Orthosteric Ligand	7W40-BB₂-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB₂-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
10.34	Single	6IBL	Arformoterol	6IBL-β₁-Arformoterol
10.34	Single	6RZ9	ONO-2770372	6RZ9-CysLT₂-ONO-2770372
10.34	Single	6TKO	Arformoterol	6TKO-β₁-Arformoterol-Arrestin2
10.34	Single	7D7M	Dinoprostone	7D7M-EP₄-Dinoprostone-Gs/β1/γ1
10.34	Single	7EW0	Ozanimod	7EW0-S1P₁-Ozanimod-Gi1/β1/γ2
10.34	Single	7LLL	Exendin-4	7LLL-GLP-1-Exendin-4-Gs/β1/γ2
10.34	Single	7PIU	Setmelanotide	7PIU-MC₄-Setmelanotide-Gs/β1/γ2
10.34	Single	8GUT	LEI-102	8GUT-CB₂-LEI-102-Gi1/β1/γ2
10.34	Single	8IUL	Latanoprost	8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34	Single	8ZX4	Lysophosphatidylinositol	8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
10.34	Single	9IZF	NKP	9IZF-LPA₁-NKP-Gi1/β1/γ2
10.34	Consensus	cb1_on_gp	Orthosteric Ligand	6KPG-CB₁-AM841-Gi1/β1/γ2 8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
10.34	Consensus	cyslt2_off	Orthosteric Ligand	6RZ7-CysLT₂-ONO-2570366 6RZ8-CysLT₂-ONO-2080365 6RZ9-CysLT₂-ONO-2770372
10.34	Consensus	gi_s1p	Orthosteric Ligand	7VIE-S1P₁-S1P-Gi1/β1/γ2 7EW3-S1P₃-S1P-Gi1/β1/γ2 7EVY-S1P₁-Siponimod-Gi1/β1/γ2 7EW1-S1P₅-Siponimod-Gi1/β1/γ2 7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P₁-CBP-307-Gi1/β1/γ2 7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2 7EW0-S1P₁-Ozanimod-Gi1/β1/γ2 7EW7-S1P₁-SEW2871-Gi1/β1/γ2
10.26	Single	6LPB	PACAP	6LPB-PAC₁-PACAP-Gs/β1/γ1
10.26	Single	7VBH	Peptide-20	7VBH-GLP-1-Peptide-20-Gs/β1/γ2
10.26	Single	8FLS	Abaloparatide	8FLS-PTH1-Abaloparatide-Gs/β1/γ2
10.00	Single	4UG2	CGS21680	4UG2-A_2A-CGS21680
10.00	Single	6G79	Donitriptan	6G79-5-HT_1B-Donitriptan-Go/β1/γ2
10.00	Single	6XBJ	Cholesterol	6XBJ-SMO-Cholesterol-Gi1/β1/γ2
10.00	Single	7AUE	Setmelanotide	7AUE-MC₄-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
10.00	Single	7V35	Peptide-20	7V35-Glucagon-Peptide-20-Gs/β1/γ2
10.00	Single	7VVM	PTH	7VVM-PTH1-PTH-Gs/β1/γ2
10.00	Single	7XKD	Beta-Hydroxyandrosterone	7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
10.00	Single	7XKE	Beta-Hydroxyandrosterone	7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
10.00	Single	8HQM	NPGLY	8HQM-GPR132-NPGLY-Gi1/β1/γ2
10.00	Single	8HVI	NOX-6-7	8HVI-GPR132-NOX-6-7-Gi1/β1/γ2
10.00	Single	8IA7	Cholecystokinin-8	8IA7-CCK_B-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
10.00	Single	8JLR	A77636	8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
10.00	Single	8X3L	XWD	8X3L-CB₂-XWD-Gi1/β1/γ2
10.00	Single	8X9S	5alpha-DHT	8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
10.00	Single	8XZF	WN561	8XZF-Apelin-WN561-Gi1/β1/γ2
10.00	Single	9IV2	5alpha-DHT	9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
10.00	Consensus	cxcr3_on	Orthosteric Ligand	8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
10.00	Consensus	dop_on	Orthosteric Ligand	8F7S-δ-Deltorphin-Gi1/β1/γ2
10.00	Consensus	ox2_on	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX₂-TAK-925-Gi1/β1/γ2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00	Consensus	ox2_on_gp	Orthosteric Ligand	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX₂-TAK-925-Gi1/β1/γ2 7L1U-OX₂-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00	Consensus	s1p_on	Orthosteric Ligand	s1p1_on s1p3_on s1p5_on
10.00	Consensus	s1p_on_gp	Orthosteric Ligand	s1p1_on_gp s1p3_on_gp s1p5_on_gp
9.76	Single	7Y36	Teriparatide	7Y36-PTH1-Teriparatide-Gs/β1/γ2
9.76	Single	8JIU	SAR425899	8JIU-Glucagon-SAR425899-Gs/β1/γ2
9.76	Single	9JR3	PTH	9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.68	Single	6RZ8	ONO-2080365	6RZ8-CysLT₂-ONO-2080365
9.68	Single	6X19	CHU-128	6X19-GLP-1-CHU-128-Gs/β1/γ2
9.68	Single	7F4I	SHU9119	7F4I-MC₁-SHU9119-chim(NtGi1-Gs)/β1/γ2
9.68	Single	7T6U	CGEN-855A	7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
9.68	Single	7TD4	Siponimod	7TD4-S1P₁-Siponimod-Gi1/β1/γ2
9.68	Single	7WKD	TRH	7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68	Single	8DCR	Dobutamine	8DCR-β₁-Dobutamine-Gs/β1/γ2
9.68	Single	8FYL	Vilazodone	8FYL-5-HT_1A-Vilazodone-Gi1/β1/γ1
9.68	Single	8IEB	A1LYA	8IEB-GPR156-A1LYA
9.68	Single	8IEI	A1LYA	8IEI-GPR156-A1LYA
9.68	Single	8IEP	A1LYA	8IEP-GPR156-A1LYA
9.68	Single	8IEP	A1LYA	8IEP-GPR156-A1LYA
9.68	Single	8INR	Alpha-MSH	8INR-MC₅-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
9.68	Single	8J6R	MK6892	8J6R-HCA₂-MK6892-Gi1/β1/γ2
9.68	Single	8JIQ	Peptide-15	8JIQ-Glucagon-Peptide-15-Gs/β1/γ2
9.68	Single	8XBH	S3E-LysoPS	8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
9.68	Single	8ZJD	Kisspeptin-10	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
9.68	Consensus	gq_kisspeptin	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
9.68	Consensus	kiss1_on_gp	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
9.68	Consensus	kisspeptin_on_gp	Orthosteric Ligand	kiss1_on_gp
9.68	Consensus	mop_off	Orthosteric Ligand	4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
9.52	Single	6E3Y	Calcitonin gene-related peptide-1	6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
9.52	Single	6OT0	25(S)-Epoxycholesterol	6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
9.52	Single	6XBM	25(S)-Epoxycholesterol	6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
9.52	Single	7VDM	Substance-P	7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
9.52	Single	8A2O	Theophylline	8A2O-A_2A-Theophylline-Na
9.38	Single	7DDZ	JNJ-31020028	7DDZ-Y₂-JNJ-31020028
9.38	Single	7E14	Orforglipron	7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
9.38	Single	8IEB	A1LYA	8IEB-GPR156-A1LYA
9.38	Single	8IOC	Gamma-MSH	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
9.38	Single	8KH5	Lysophosphatidylserine	8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
9.38	Consensus	npy2_off	Orthosteric Ligand	7DDZ-Y₂-JNJ-31020028
9.38	Consensus	s1p3_on_gp	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
9.09	Single	5WKT	Octyl-Beta-D-Glucopyranoside	5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
9.09	Single	6ME5	Agomelatine	6ME5-MT₁-Agomelatine
9.09	Single	6UUN	Adrenomedullin	6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
9.09	Single	7WC5	Psilocin	7WC5-5-HT_2A-Psilocin
9.09	Single	8J24	Acetic acid	8J24-FFA2-Acetic acid-Gi1/β1/γ2
9.09	Single	8J6Q	Compound 9n	8J6Q-HCA₂-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
9.09	Single	8RQL	Flufenamic acid	8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
9.09	Single	8XGU	TAK448	8XGU-Kiss1-TAK448-Gi1/β1/γ2
9.09	Single	8XIQ	L796778	8XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
9.09	Single	9IV1	5alpha-DHT	9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
9.09	Consensus	mc3_on	Orthosteric Ligand	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
9.09	Consensus	mc3_on_gp	Orthosteric Ligand	8IOC-MC₃-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
8.82	Single	7TYI	Amylin	7TYI-CT-Amylin-Gs/β1/γ2
8.82	Single	8IED	A1LYA	8IED-GPR156-A1LYA-Go/β1/γ2
8.82	Single	8IED	A1LYA	8IED-GPR156-A1LYA-Go/β1/γ2
8.82	Single	8IHF	MK6892	8IHF-HCA₂-MK6892-Gi1/β1/γ2
8.82	Single	8YW3	Retatrutide	8YW3-GLP-1-Retatrutide-Gs/β1/γ2
8.82	Single	8YW4	Retatrutide	8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
8.82	Single	8YW5	Retatrutide	8YW5-Glucagon-Retatrutide-Gs/β1/γ2
8.70	Single	3VGA	ZM-241385	3VGA-A_2A-ZM-241385-Antibody
8.70	Single	7VDH	C48/80	7VDH-MRGPRX2-C48/80-Gi1/β1/γ2
8.70	Single	8A2P	LUAA47070	8A2P-A_2A-LUAA47070-Na
8.70	Single	8H2G	Niacin	8H2G-HCA₂-Niacin-Gi1/β1/γ2
8.70	Single	8HSC	Fab046	8HSC-GPR20-Fab046-Gi1/β1/γ2
8.70	Single	8J6P	Compound 9n	8J6P-HCA₂-Niacin-Compound 9n-Gi1/β1/γ2
8.70	Single	8JHY	Compound 9n	8JHY-HCA₂-Compound 9n-Gi1/β1/γ2
8.70	Single	8JII	Compound 9n	8JII-HCA₂-Niacin-Compound 9n-Gi1/β1/γ2
8.70	Single	8K5B	Niacin	8K5B-HCA₂-Niacin
8.70	Single	8YRG	Fospropofol	8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70	Single	9B9Y	7DY	9B9Y-CB₁-7DY
8.70	Single	9EPQ	11,20-Ethanoretinal	9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
8.70	Single	9IQT	Niacin	9IQT-HCA₂-Niacin-Gi1/β1/γ2
8.70	Single	9J5V	CpY	9J5V-LPA₁-CpY-Gi1/β1/γ2
8.70	Single	9L3Z	LRH7-C2	9L3Z-CML1-LRH7-C2
8.57	Single	7TYW	Calcitonin-1	7TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
8.57	Single	7XV3	Lysophosphatidylserine	7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
8.57	Single	8E3Z	VIP	8E3Z-VPAC₁-VIP-Gs/β1/γ2
8.57	Single	8IOD	PG-901	8IOD-MC₅-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
8.57	Consensus	p2y10_on	Orthosteric Ligand	8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
8.33	Single	2X72	All-trans-Retinal	2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
8.33	Single	3V2W	PubChem 51892645	3V2W-S1P₁-PubChem 51892645
8.33	Single	5K2D	ZM-241385	5K2D-A_2A-ZM-241385-Na
8.33	Single	5OLH	Vipadenant	5OLH-A_2A-Vipadenant-Na
8.33	Single	5OLO	Tozadenant	5OLO-A_2A-Tozadenant-Na
8.33	Single	5OLV	LUAA41063	5OLV-A_2A-LUAA41063-Na
8.33	Single	5U09	Taranabant	5U09-CB₁-Taranabant
8.33	Single	6DS0	Ly266097	6DS0-5-HT_2B-Ly266097
8.33	Single	6JZH	ZM-241385	6JZH-A_2A-ZM-241385-Na
8.33	Single	6ME9	Ramelteon	6ME9-MT₂-Ramelteon
8.33	Single	6NWE	Octyl-Beta-D-Glucopyranoside	6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
8.33	Single	6PS7	ZM-241385	6PS7-A_2A-ZM-241385-Na
8.33	Single	6RNK	NF-56-EJ40	6RNK-Succinate-NF-56-EJ40
8.33	Single	7BR3	Elagolix	7BR3-GnRH₁-Elagolix
8.33	Single	7D3S	Secretin	7D3S-Secretin-Secretin-Gs/β1/γ2
8.33	Single	7KI0	Semaglutide	7KI0-GLP-1-Semaglutide-Gs/β1/γ2
8.33	Single	7TUZ	7-alpha,25-dihydroxycholesterol	7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
8.33	Single	7VAB	Non-Acylated Tirzepatide	7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
8.33	Single	7VDL	Cortistatin-14	7VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
8.33	Single	7VIH	CBP-307	7VIH-S1P₁-CBP-307-Gi1/β1/γ2
8.33	Single	7W0M	PubChem 122701908	7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
8.33	Single	7W0O	Elabela	7W0O-Apelin-Elabela-Gi1/β1/γ2
8.33	Single	7WF7	S1P	7WF7-S1P₁-S1P-Gi1/β1/γ2
8.33	Single	8DU3	PubChem 105526064	8DU3-A_2A-PubChem 105526064
8.33	Single	8DWH	PubChem 139030531	8DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33	Single	8FLR	PTHrP(1-36)	8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
8.33	Single	8IJA	Niacin	8IJA-HCA₂-Niacin-Gi1/β1/γ2
8.33	Single	8JPP	Succinic acid	8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
8.33	Single	8XXV	Indomethacin	8XXV-DP₂-Indomethacin-A1D5Q-Gi1/β1/γ2
8.33	Single	9J1P	g1:Ox	9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
8.33	Consensus	gnrh1_off	Orthosteric Ligand	7BR3-GnRH₁-Elagolix
8.33	Consensus	s1p1_off	Orthosteric Ligand	3V2W-S1P₁-PubChem 51892645
8.11	Single	6VCB	GLP-1	6VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
8.11	Single	7DTY	GIP	7DTY-GIP-GIP-Gs/β1/γ2
8.11	Single	7S1M	Ex4-D-Ala	7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
8.11	Single	7TYF	Amylin	7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
8.11	Single	7TYN	Calcitonin-1	7TYN-CT-Calcitonin-1-Gs/β1/γ2
8.11	Consensus	p2y10_on_gp	Orthosteric Ligand	8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
8.00	Single	5IU7	Q27456346	5IU7-A_2A-Q27456346-Na
8.00	Single	5JTB	ZM-241385	5JTB-A_2A-ZM-241385
8.00	Single	5TE3	Octyl-Beta-D-Glucopyranoside	5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
8.00	Single	6FK8	PubChem 132473035	6FK8-Rhodopsin-PubChem 132473035
8.00	Single	6ME3	2-Phenylmelatonin	6ME3-MT₁-2-Phenylmelatonin
8.00	Single	6ME4	2-Iodomelatonin	6ME4-MT₁-2-Iodomelatonin
8.00	Single	6ZDR	HMS1413f12	6ZDR-A_2A-HMS1413f12-Na
8.00	Single	6ZDV	Chromone 5d	6ZDV-A_2A-Chromone 5d-Na
8.00	Single	7BB6	AVP	7BB6-V₂-AVP-Gs/β1/γ2
8.00	Single	7WC9	PubChem 162421364	7WC9-5-HT_2A-PubChem 162421364
8.00	Single	7XOV	SR146131	7XOV-CCK_A-SR146131-Gs/β1/γ2
8.00	Single	8GUQ	Olorinab	8GUQ-CB₂-Olorinab-Gi1/β1/γ2
8.00	Single	8H4L	Doconexent	8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00	Single	8JLQ	Fenoldopam	8JLQ-TA1-Fenoldopam-Gs/β1/γ2
8.00	Single	8K2W	AMG487	8K2W-CXCR3-AMG487
8.00	Single	8K4N	VF0	8K4N-GPR34-VF0-Gi1/β1/γ2
8.00	Single	8K9K	Damgo	8K9K-μ-Damgo-Gi3/β1/γ1
8.00	Single	8K9L	Damgo	8K9L-μ-Damgo-VV9-Gi3/β1/γ1
8.00	Single	8RQQ	ZM-241385	8RQQ-A_2A-ZM-241385-Na
8.00	Single	8Y62	C16:0 Ceramide	8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
8.00	Single	9K1D	Butanoic acid	9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
8.00	Consensus	a2_off	Orthosteric Ligand	a2a_off
8.00	Consensus	a2a_off	Orthosteric Ligand	3RFM-A_2A-Caffeine 8C9W-A_2A-Etrumadenant 3UZA-A_2A-GTPL9236 8GNG-A_2A-Istradefylline 8CU6-A_2A-LJ-4517 7PX4-A_2A-PSB-2113 7PYR-A_2A-PSB-2115 8DU3-A_2A-PubChem 105526064 8JWY-A_2A-2-118 8PWN-A_2A-Theophylline 5IU4-A_2A-ZM-241385-Na 5OLZ-A_2A-PubChem 135566609-Na 6GT3-A_2A-Imaradenant-Na 5OLV-A_2A-LUAA41063-Na 5N2R-A_2A-PSB-36-Na 5IU7-A_2A-Q27456346-Na 5OLH-A_2A-Vipadenant-Na 5OLO-A_2A-Tozadenant-Na 6ZDR-A_2A-HMS1413f12-Na 8GNE-A_2A-KW-6356-Na 8JWZ-A_2A-AB928-Na 5IU8-A_2A-Q27456347-Na 5IUB-A_2A-Q27456344-Na 6ZDV-A_2A-Chromone 5d-Na 5IUA-A_2A-Q27456348-Na 8A2P-A_2A-LUAA47070-Na
8.00	Consensus	adenosine_on	Orthosteric Ligand	a1_on a2_on a3_on
8.00	Consensus	cb1_off	Orthosteric Ligand	5U09-CB₁-Taranabant 5TGZ-CB₁-AM6538
8.00	Consensus	cxcr3_off	Orthosteric Ligand	8K2W-CXCR3-AMG487
8.00	Consensus	gi_adenosine	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/β1/γ2 8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
8.00	Consensus	grh_off	Orthosteric Ligand	gnrh1_off
7.89	Single	6LML	Glucagon	6LML-Glucagon-Glucagon-Gi1/β1/γ1
7.89	Single	7TS0	Urocortin	7TS0-CRF₂-Urocortin-chim(NtGi1L-Go)/β1/γ2
7.89	Single	7TYL	Amylin	7TYL-CT-Amylin-Gs/β1/γ2
7.89	Single	8F0K	Pramlintide Analogue San385	8F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
7.89	Single	8FLT	M-PTH(1-14)	8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
7.89	Single	8KGG	LPS	8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
7.89	Single	8Y52	BA1	8Y52-BB₃-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
7.69	Single	4J4Q	Octyl Beta-D-Glucopyranoside	4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
7.69	Single	5TGZ	AM6538	5TGZ-CB₁-AM6538
7.69	Single	6FK7	PubChem 132473034	6FK7-Rhodopsin-PubChem 132473034
7.69	Single	6FKC	PubChem 132473039	6FKC-Rhodopsin-PubChem 132473039
7.69	Single	6FKD	PubChem 137349183	6FKD-Rhodopsin-PubChem 137349183
7.69	Single	6KPF	PubChem 145915889	6KPF-CB₂-PubChem 145915889-Gi1/β1/γ2
7.69	Single	6Z10	PubChem 154585554	6Z10-Succinate-PubChem 154585554
7.69	Single	7CFM	P395	7CFM-GPBA-P395-Gs/β1/γ2
7.69	Single	7CRH	SKF83959	7CRH-D₁-SKF83959-Gs/β1/γ2
7.69	Single	7JOZ	VFP	7JOZ-D₁-VFP-Gs/β1/γ2
7.69	Single	7LJC	SKF-81297	7LJC-D₁-SKF-81297-Mevidalen-Gs/β1/γ2
7.69	Single	7PP1	Selatogrel	7PP1-P2Y₁₂-Selatogrel
7.69	Single	7RBT	Tirzepatide	7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
7.69	Single	7TYX	Amylin	7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
7.69	Single	7VGZ	Remalteon	7VGZ-MT₁-Remalteon-Gi1/β1/γ2
7.69	Single	7VIE	S1P	7VIE-S1P₁-S1P-Gi1/β1/γ2
7.69	Single	7VIF	S-FTY720-P	7VIF-S1P₁-S-FTY720-P-Gi1/β1/γ2
7.69	Single	7VKT	LTB4	7VKT-BLT₁-LTB4-Gi1/β1/γ2
7.69	Single	7WC8	Lumateperone	7WC8-5-HT_2A-Lumateperone
7.69	Single	7YK7	DC591053	7YK7-RXFP4-DC591053-Gi2/β1/γ2
7.69	Single	7YXA	ONO-5430608	7YXA-S1P₅-ONO-5430608
7.69	Single	8CU7	LJ-4517	8CU7-A_2A-LJ-4517-Na
7.69	Single	8EJK	TAK-875	8EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.69	Single	8GCM	L902688	8GCM-EP₄-L902688-Gi1/β1/γ2
7.69	Single	8JT8	(R)-IHCH-7179	8JT8-5-HT_2A-(R)-IHCH-7179
7.69	Single	8PJK	ST171	8PJK-5-HT_1A-ST171-t7m-Gi1/β1/γ1
7.69	Single	8RLN	LUF5834	8RLN-A_2A-LUF5834
7.69	Single	8XBG	S3E-LysoPS	8XBG-GPR34-S3E-LysoPS
7.69	Single	8XJL	PGF2-alpha	8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
7.69	Single	8YH5	Riboprine	8YH5-A_3A-Riboprine-Gi1/β1/γ2
7.69	Single	8YIC	SAR247799	8YIC-S1P₁-SAR247799-Gi1/β1/γ2
7.69	Single	9IVG	GLP-1 (Truncated)	9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
7.69	Consensus	a3_on	Orthosteric Ligand	a3a_on
7.69	Consensus	adenosine_on_gp	Orthosteric Ligand	a1_on_gp a2_on_gp a3_on_gp
7.69	Consensus	alicarboxylic_off	Orthosteric Ligand	succinate_off
7.69	Consensus	alicarboxylic_on_gp	Orthosteric Ligand	succinate_on_gp hca_on_gp
7.69	Consensus	blt1_on	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/β1/γ2
7.69	Consensus	blt1_on_gp	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/β1/γ2
7.69	Consensus	blt_on	Orthosteric Ligand	blt1_on
7.69	Consensus	blt_on_gp	Orthosteric Ligand	blt1_on_gp
7.69	Consensus	gi_alicarboxylic	Orthosteric Ligand	gi_hca gi_succinate
7.69	Consensus	gi_leukotriene	Orthosteric Ligand	7VKT-BLT₁-LTB4-Gi1/β1/γ2
7.69	Consensus	leukotriene_on	Orthosteric Ligand	blt_on
7.69	Consensus	leukotriene_on_gp	Orthosteric Ligand	blt_on_gp
7.69	Consensus	succinate_off	Orthosteric Ligand	6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
7.50	Single	7TZF	Amylin	7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
7.50	Single	8F2A	Pramlintide Analogue San385	8F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
7.50	Single	8FLU	Long-Acting PTH	8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
7.50	Single	9AUC	Calcitonin gene-related peptide-1	9AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
7.41	Single	2Y00	Dobutamine	2Y00-β₁-Dobutamine
7.41	Single	4PHU	Fasiglifam	4PHU-FFA1-Fasiglifam
7.41	Single	4RWD	DIPP-NH2	4RWD-δ-DIPP-NH2-Na
7.41	Single	5C1M	BU72	5C1M-μ-BU72
7.41	Single	5OM4	PubChem 135566609	5OM4-A_2A-PubChem 135566609-Na
7.41	Single	6GDG	NECA	6GDG-A_2A-NECA-Gs/β1/γ1
7.41	Single	6LUQ	Haloperidol	6LUQ-D₂-Haloperidol
7.41	Single	6M9T	Misoprostol-FA	6M9T-EP₃-Misoprostol-FA
7.41	Single	6ME6	2-Phenylmelatonin	6ME6-MT₂-2-Phenylmelatonin
7.41	Single	6ME7	2-Phenylmelatonin	6ME7-MT₂-2-Phenylmelatonin
7.41	Single	7C4S	S1P	7C4S-S1P₃-S1P
7.41	Single	7CFN	INT-777	7CFN-GPBA-INT-777-Gs/β1/γ2
7.41	Single	7CKX	A77636	7CKX-D₁-A77636-Gs/β1/γ2
7.41	Single	7EUO	fMLF	7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
7.41	Single	7LD3	Adenosine	7LD3-A₁-Adenosine-PubChem 25263603-Gi2/β1/γ2
7.41	Single	7VFX	fMLF	7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
7.41	Single	7VUH	JNJ-63533054	7VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
7.41	Single	7VV0	PAMP-12	7VV0-MRGPRX2-PAMP-12
7.41	Single	7W41	PD176252	7W41-BB₂-PD176252
7.41	Single	7WIG	L-054,264	7WIG-SST2-L-054,264-Gi1/β1/γ2
7.41	Single	7X1T	Taltirelin	7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.41	Single	8EJC	TAK-875	8EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.41	Single	8GD9	Rivenprost	8GD9-EP₄-Rivenprost-Gs/β1/γ2
7.41	Single	8GDC	PGE2	8GDC-EP₃-PGE2-Gi1/β1/γ2
7.41	Single	8HNL	PS372424	8HNL-CXCR3-PS372424-Gi1/β1/γ2
7.41	Single	8ID4	Linoleic acid	8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
7.41	Single	8IZ4	Lysophosphatidylserine	8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
7.41	Single	8J6J	GSK256073	8J6J-HCA₂-GSK256073-Gi1/β1/γ2
7.41	Single	8JXS	PF-6142	8JXS-D₁-PF-6142
7.41	Single	8K8J	Fenofibrate	8K8J-CB₁-Fenofibrate-chim(Gs-CtGq)/β1/γ2
7.41	Single	8S4D	CMF-019	8S4D-Apelin-CMF-019
7.41	Single	8VVE	norBNI	8VVE-κ-norBNI-Gi1/β1/γ2
7.41	Single	8WGB	W9R	8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
7.41	Consensus	a3_on_gp	Orthosteric Ligand	a3a_on_gp
7.41	Consensus	a3a_on	Orthosteric Ligand	8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
7.41	Consensus	a3a_on_gp	Orthosteric Ligand	8X17-A_3A-Namodenoson-Gi1/β1/γ2 8X16-A_3A-Piclidenoson-Gi1/β1/γ2
7.41	Consensus	bb2_off	Orthosteric Ligand	7W41-BB₂-PD176252
7.41	Consensus	blt1_off	Orthosteric Ligand	5X33-BLT₁-BIIL260 7K15-BLT₁-MKD046-Na
7.41	Consensus	blt_off	Orthosteric Ligand	blt1_off
7.41	Consensus	bombesin_off	Orthosteric Ligand	bb2_off
7.41	Consensus	d2_on	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2 8IRS-D₂-Rotigotine-Gi1/β1/γ2
7.41	Consensus	fpr1-alx_on	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
7.41	Consensus	fpr1-alx_on_gp	Orthosteric Ligand	7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
7.32	Single	8JIP	MEDI0382	8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
7.32	Single	8JIR	SAR425899	8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
7.14	Single	3P0G	BI167107	3P0G-β₂-BI167107
7.14	Single	3PDS	Hydroxybenzylisoproterenol	3PDS-β₂-Hydroxybenzylisoproterenol
7.14	Single	4LDL	Hydroxybenzylisoproterenol	4LDL-β₂-Hydroxybenzylisoproterenol
7.14	Single	6GT3	Imaradenant	6GT3-A_2A-Imaradenant-Na
7.14	Single	6J21	Aprepitant	6J21-NK₁-Aprepitant
7.14	Single	6NI3	BI167107	6NI3-β₂-BI167107-Gs/β1/γ2
7.14	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
7.14	Single	6RZ5	Zafirlukast	6RZ5-CysLT₁-Zafirlukast-Na
7.14	Single	7B6W	Cyclazosin	7B6W-α_1b-Cyclazosin
7.14	Single	7EW1	Siponimod	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
7.14	Single	7EW3	S1P	7EW3-S1P₃-S1P-Gi1/β1/γ2
7.14	Single	7JV5	SKF81297	7JV5-D₁-SKF81297-Gs/β1/γ2
7.14	Single	7JVP	SKF83959	7JVP-D₁-SKF83959-Gs/β1/γ2
7.14	Single	7TYO	Calcitonin	7TYO-CT-Calcitonin-Gs/β1/γ2
7.14	Single	7TYY	Calcitonin-1	7TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
7.14	Single	7WVX	Humanin	7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
7.14	Single	8E0G	BU72	8E0G-μ-BU72
7.14	Single	8IYH	MK6892	8IYH-HCA₂-MK6892-Go/β1/γ2
7.14	Single	8JGF	BAM8-22	8JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14	Single	8JIT	MEDI0382	8JIT-Glucagon-MEDI0382-Gs/β1/γ2
7.14	Single	8JT6	(R)-IHCH-7179	8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/β1/γ2
7.14	Single	8VVF	JDTic	8VVF-κ-JDTic-Gi1/β1/γ2
7.14	Single	8WU1	PubChem 119025665	8WU1-CB₁-PubChem 119025665-Arrestin2
7.14	Single	8X16	Piclidenoson	8X16-A_3A-Piclidenoson-Gi1/β1/γ2
7.14	Single	8XBI	S3E-LysoPS	8XBI-GPR34-S3E-LysoPS
7.14	Single	8XZI	CMF-019	8XZI-Apelin-CMF-019-Gi1/β1/γ2
7.14	Single	8YH6	Namodenoson	8YH6-A_3A-Namodenoson-Gi1/β1/γ2
7.14	Single	9BJK	NAM	9BJK-μ-Naloxone-NAM
7.14	Single	9GE2	ML184	9GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
7.14	Consensus	cyslt1_off	Orthosteric Ligand	6RZ5-CysLT₁-Zafirlukast-Na 6RZ4-CysLT₁-Pranlukast-Na
7.14	Consensus	gi_dopamine	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2 7CMV-D₃-PD128907-Gi1/β1/γ2 7CMU-D₃-Pramipexole-Gi1/β1/γ2 8IRS-D₂-Rotigotine-Gi1/β1/γ2 8IRT-D₃-Rotigotine-Gi1/β1/γ2
7.14	Consensus	gs_adrenergic	Orthosteric Ligand	7DHI-β₂-Salbutamol-Gs/β1/γ2 7XJI-β₃-Solabegron-Gs/β1/γ2 7JJO-β₁-Isoprenaline-Gs/β1/γ2 6NI3-β₂-BI167107-Gs/β1/γ2 8DCR-β₁-Dobutamine-Gs/β1/γ2 7XJH-β₃-Isoproterenol-Gs/β1/γ2 7DH5-β₃-Mirabegron-Gs/β1/γ2
7.14	Consensus	s1p5_on	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
7.14	Consensus	s1p5_on_gp	Orthosteric Ligand	7EW1-S1P₅-Siponimod-Gi1/β1/γ2
6.90	Single	4RWA	DIPP-NH2	4RWA-δ-DIPP-NH2
6.90	Single	5X33	BIIL260	5X33-BLT₁-BIIL260
6.90	Single	6AK3	Dinoprostone IPGE2	6AK3-EP₃-Dinoprostone IPGE2
6.90	Single	6CM4	Risperidone	6CM4-D₂-Risperidone
6.90	Single	6DRY	Methylergonovine	6DRY-5-HT_2B-Methylergonovine
6.90	Single	6VMS	Bromoergocryptine	6VMS-D₂-Bromoergocryptine-Gi1/β1/γ2
6.90	Single	6XBL	Cholesterol	6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
6.90	Single	7EO4	BAF312	7EO4-S1P₁-BAF312-Gi1/β1/γ2
6.90	Single	7EVY	Siponimod	7EVY-S1P₁-Siponimod-Gi1/β1/γ2
6.90	Single	7L1V	PubChem 155491009	7L1V-OX₂-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
6.90	Single	7SUS	PubChem 122701908	7SUS-Apelin-PubChem 122701908
6.90	Single	7T6B	S1P	7T6B-S1P₂-S1P-chim(NtGi1L-G13)/β1/γ2
6.90	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
6.90	Single	7WCN	AR231453	7WCN-GPR119-AR231453-Gs/β1/γ2
6.90	Single	7XW6	ML109	7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
6.90	Single	7XW9	TRH	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.90	Single	7YMJ	Tamsulosin	7YMJ-Alpha1A-Tamsulosin
6.90	Single	8G05	6-OAU	8G05-GPR84-6-OAU-Gi1/β1/γ2
6.90	Single	8GCP	PGE2	8GCP-EP₄-PGE2-Gi1/β1/γ2
6.90	Single	8ID9	Eicosapentaenoic acid	8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
6.90	Single	8IRS	Rotigotine	8IRS-D₂-Rotigotine-Gi1/β1/γ2
6.90	Single	8JJ8	Formoterol	8JJ8-β₂-Formoterol
6.90	Single	8JZ7	MK6892	8JZ7-HCA₂-MK6892-Gi1/β1/γ2
6.90	Single	8XQN	Cholesterol	8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
6.90	Single	8XQS	Cholesterol	8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
6.90	Single	9GYO	P395	9GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
6.90	Single	9MQL	Isoquinuclidine	9MQL-κ-Isoquinuclidine
6.90	Consensus	alpha1_off	Orthosteric Ligand	alpha1a_off
6.90	Consensus	alpha1a_off	Orthosteric Ligand	7YMJ-Alpha1A-Tamsulosin
6.90	Consensus	beta_on	Orthosteric Ligand	beta1_on beta2_on beta3_on
6.90	Consensus	beta_on_gp	Orthosteric Ligand	beta1_on_gp beta2_on_gp beta3_on_gp
6.90	Consensus	d2_on_gp	Orthosteric Ligand	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2 8IRS-D₂-Rotigotine-Gi1/β1/γ2
6.90	Consensus	kop_on	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
6.90	Consensus	leukotriene_off	Orthosteric Ligand	blt_off cyslt_off
6.90	Consensus	mop_on	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
6.90	Consensus	mop_on_gp	Orthosteric Ligand	8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
6.90	Consensus	orexin_on	Orthosteric Ligand	ox2_on
6.90	Consensus	s1p3_on	Orthosteric Ligand	7EW3-S1P₃-S1P-Gi1/β1/γ2 7EW4-S1P₃-CYM5541-Gi1/β1/γ2 7EW2-S1P₃-Fingolimod-Gi1/β1/γ2
6.90	Consensus	trh_on	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.90	Consensus	trh_on_gp	Orthosteric Ligand	7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.67	Single	5UNG	PubChem 15780052	5UNG-AT₂-PubChem 15780052
6.67	Single	6BQH	Ritanserin	6BQH-5-HT_2C-Ritanserin
6.67	Single	6H7L	Dobutamine	6H7L-β₁-Dobutamine
6.67	Single	7CX4	Evatanepag	7CX4-EP₂-Evatanepag-Gs/β1/γ2
6.67	Single	7EVZ	Cenerimod	7EVZ-S1P₁-Cenerimod-Gi1/β1/γ2
6.67	Single	7JVR	Bromoergocryptine	7JVR-D₂-Bromoergocryptine-Gi1/β1/γ2
6.67	Single	7QVM	Oxytocin	7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
6.67	Single	7WVV	fMLFII	7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
6.67	Single	7X1U	TRH	7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67	Single	7XK2	MK6892	7XK2-HCA₂-MK6892-Gi1/β1/γ2
6.67	Single	8GAG	PubChem 170838490	8GAG-CB₁-PubChem 170838490-Gi1/β1/γ2
6.67	Single	8ID8	TUG-891	8ID8-FFA4-TUG-891-Gi1/β1/γ2
6.67	Single	8J19	LY237	8J19-GPR84-LY237-Gi1/β1/γ2
6.67	Single	8XIO	L797591	8XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
6.67	Consensus	5ht2c_off	Orthosteric Ligand	6BQH-5-HT_2C-Ritanserin
6.67	Consensus	beta1_on	Orthosteric Ligand	8DCR-β₁-Dobutamine-Gs/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
6.67	Consensus	beta1_on_gp	Orthosteric Ligand	8DCR-β₁-Dobutamine-Gs/β1/γ2 7S0F-β₁-Isoprenaline-Gi1/β1/γ2
6.67	Consensus	d2_off	Orthosteric Ligand	6CM4-D₂-Risperidone 6LUQ-D₂-Haloperidol 7DFP-D₂-Spiperone
6.67	Consensus	fp-alpha_on	Orthosteric Ligand	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67	Consensus	fp-alpha_on_gp	Orthosteric Ligand	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67	Consensus	kop_on_gp	Orthosteric Ligand	8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
6.67	Consensus	orexin_on_gp	Orthosteric Ligand	ox2_on_gp
6.52	Single	8F0J	Pramlintide Analogue San45	8F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
6.45	Single	3NY9	ICI118-551	3NY9-β₂-ICI118-551
6.45	Single	5ZTY	AM10257	5ZTY-CB₂-AM10257
6.45	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
6.45	Single	7CX2	PGE2	7CX2-EP₂-PGE2-Gs/β1/γ2
6.45	Single	7SK9	CCX662	7SK9-ACKR3-CCX662
6.45	Single	8GDA	L902688	8GDA-EP₄-L902688-Gs/β1/γ2
6.45	Single	8IEI	A1LYA	8IEI-GPR156-A1LYA
6.45	Single	8IQ4	Carboprost	8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
6.45	Single	8IUM	Tafluprost acid	8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
6.45	Single	8SAI	1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine	8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
6.45	Single	8X5Y	Astemizole	8X5Y-H₁-Astemizole
6.45	Single	8XQL	Cholesterol	8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
6.45	Single	8XQO	Cholesterol	8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
6.45	Consensus	cb2_off	Orthosteric Ligand	5ZTY-CB₂-AM10257
6.45	Consensus	kiss1_on	Orthosteric Ligand	8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
6.45	Consensus	kisspeptin_on	Orthosteric Ligand	kiss1_on
6.38	Single	8F2B	Pramlintide Analogue San45	8F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
6.25	Single	4AMJ	S-Carvedilol	4AMJ-β₁-S-Carvedilol
6.25	Single	5UNF	PubChem 15780052	5UNF-AT₂-PubChem 15780052
6.25	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
6.25	Single	7CX3	Taprenepag	7CX3-EP₂-Taprenepag-Gs/β1/γ2
6.25	Single	7RTB	Peptide-19	7RTB-GLP-1-Peptide-19-Gs/β1/γ2
6.25	Single	8G59	TUG-891	8G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
6.25	Single	8IZB	Lysophosphatidylserine	8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
6.25	Single	8KIG	SHU9119	8KIG-MC₃-SHU9119-Ca
6.25	Single	8WKY	PG-934	8WKY-MC₄-PG-934
6.06	Single	6HLO	Aprepitant	6HLO-NK₁-Aprepitant
6.06	Single	7VBI	Non-Acylated Tirzepatide	7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
5.88	Single	6D32	Cyclopamine	6D32-SMO-Cyclopamine-Cyclopamine
5.88	Single	6D35	Cholesterol	6D35-SMO-Cholesterol
5.88	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
5.88	Single	6N51	Quisqualate	6N51-mGlu5; mGlu5-Quisqualate
5.88	Single	6PT2	KGCHM07	6PT2-δ-KGCHM07
5.88	Single	6UO8	SKF97541	6UO8-GABA_B1, GABA_B2-SKF97541-GS39783
5.88	Single	6UO9	SKF97541	6UO9-GABA_B1, GABA_B2-SKF97541
5.88	Single	6W25	SHU9119	6W25-MC₄-SHU9119-Ca
5.88	Single	6W2X	PubChem 5311042	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
5.88	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
5.88	Single	6W2Y	PubChem 5311042	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
5.88	Single	7C7Q	Baclofen	7C7Q-GABA_B1, GABA_B2-Baclofen-PubChem 7023848
5.88	Single	7C7S	CGP54626	7C7S-GABA_B1, GABA_B2-CGP54626
5.88	Single	7CUM	CGP54626	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
5.88	Single	7DD5	Ca	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.88	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.88	Single	7DD5	Ca	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.88	Single	7DD5	Ca; Ca; Tryptophan; NPS-2143	7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
5.88	Single	7DGE	Quisqualate	7DGE-mGlu1; mGlu1-Quisqualate
5.88	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
5.88	Single	7DTT	Ca	7DTT-CaS-Ca-Ca
5.88	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
5.88	Single	7DTU	Tryptophan	7DTU-CaS-Tryptophan
5.88	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
5.88	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
5.88	Single	7DTV	Ca	7DTV-CaS-Ca-Ca; Tryptophan
5.88	Single	7DTV	Ca; Tryptophan	7DTV-CaS-Ca-Ca; Tryptophan
5.88	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.88	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.88	Single	7E6T	Ca	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.88	Single	7E6T	Ca; Ca; Cyclomethyltryptophan; PO4	7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.88	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
5.88	Single	7E9G	Eglumetad	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
5.88	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
5.88	Single	7E9H	Phosphoserine	7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
5.88	Single	7EB2	Baclofen	7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
5.88	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
5.88	Single	7EPB	Eglumetad	7EPB-mGlu2; mGlu2-Eglumetad
5.88	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
5.88	Single	7FD8	Quisqualate	7FD8-mGlu5; mGlu5-Quisqualate
5.88	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
5.88	Single	7FD9	LY341495	7FD9-mGlu5; mGlu5-LY341495
5.88	Single	7FIH	hCG	7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
5.88	Single	7FII	hCG	7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
5.88	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
5.88	Single	7M3E	Ca; Ca; Tryptophan; NPS-2143	7M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
5.88	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.88	Single	7M3F	Ca; Ca; Tryptophan; Cinacalcet; PO4	7M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.88	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.88	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.88	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.88	Single	7M3G	Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4	7M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.88	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
5.88	Single	7MTQ	LY341495	7MTQ-mGlu2; mGlu2-LY341495
5.88	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.88	Single	7MTR	Glutamate	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
5.88	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
5.88	Single	7MTS	Glutamate	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
5.88	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.88	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.88	Single	7SIL	Ca	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.88	Single	7SIL	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
5.88	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.88	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.88	Single	7SIM	Ca	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.88	Single	7SIM	Ca; Ca; Cyclomethyltryptophan; PO4	7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
5.88	Single	7T6T	fMLFII	7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
5.88	Single	7T9N	M22 Fab	7T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
5.88	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
5.88	Single	7WI6	LY341495	7WI6-mGlu3; mGlu3-LY341495
5.88	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
5.88	Single	7WI8	LY341495	7WI8-mGlu3; mGlu3-LY341495
5.88	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
5.88	Single	7WIH	LY2794193	7WIH-mGlu3; mGlu3-LY2794193
5.88	Single	7XW6	M22 Fab	7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
5.88	Single	7XW7	K1-70	7XW7-TSH-K1-70
5.88	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
5.88	Single	8JCU	LY341495	8JCU-mGlu2; mGlu3-LY341495
5.88	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
5.88	Single	8JCV	LY341495	8JCV-mGlu2; mGlu3-LY341495
5.88	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
5.88	Single	8JCW	LY341495	8JCW-mGlu2; mGlu3-LY341495
5.88	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
5.88	Single	8JCX	LY341495	8JCX-mGlu2; mGlu3-LY341495
5.88	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
5.88	Single	8JCY	LY341495	8JCY-mGlu2; mGlu3-LY341495
5.88	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
5.88	Single	8JCZ	LY341495	8JCZ-mGlu2; mGlu3-LY341495
5.88	Single	8JD0	Glutamate	8JD0-mGlu2; mGlu3-Glutamate-NAM563
5.88	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
5.88	Single	8JD1	Glutamate	8JD1-mGlu2; mGlu3-Glutamate
5.88	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
5.88	Single	8JD2	Glutamate	8JD2-mGlu2; mGlu3-Glutamate
5.88	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
5.88	Single	8JD3	Glutamate	8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
5.88	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
5.88	Single	8JD4	Glutamate	8JD4-mGlu2; mGlu4-Glutamate
5.88	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
5.88	Single	8JD5	Glutamate	8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
5.88	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
5.88	Single	8JD6	Phosphoserine	8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
5.88	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.88	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.88	Single	8SZF	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
5.88	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
5.88	Single	8SZG	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
5.88	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
5.88	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
5.88	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
5.88	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
5.88	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
5.88	Single	8T7H	Quisqualate	8T7H-mGlu5; mGlu5-Quisqualate
5.88	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
5.88	Single	8T8M	Quisqualate	8T8M-mGlu5; mGlu5-Quisqualate
5.88	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
5.88	Single	8TAO	Quisqualate	8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
5.88	Single	8TQB	Ca; PAM VU6023326	8TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
5.88	Single	8TQB	Ca; PAM VU6023326	8TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
5.88	Single	8TR0	LY341495	8TR0-mGlu3; mGlu3-LY341495
5.88	Single	8TR0	LY341495	8TR0-mGlu3; mGlu3-LY341495
5.88	Single	8TR2	Ca; LY379268	8TR2-mGlu3; mGlu3-Ca; LY379268-Ca
5.88	Single	8TR2	Ca; LY379268	8TR2-mGlu3; mGlu3-Ca; LY379268-Ca
5.88	Single	8TRC	LY341495	8TRC-mGlu3; mGlu3-LY341495
5.88	Single	8TRC	LY341495	8TRC-mGlu3; mGlu3-LY341495
5.88	Single	8TRD	LY341495	8TRD-mGlu3; mGlu3-LY341495
5.88	Single	8TRD	LY341495	8TRD-mGlu3; mGlu3-LY341495
5.88	Single	8WG9	(2S)-2-amino-4-phosphonobutanoic acid	8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
5.88	Single	8WGB	Glutammate	8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
5.88	Single	8WGB	Glutammate	8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
5.88	Single	8WGC	LY379268	8WGC-mGlu4; mGlu2-LY379268
5.88	Single	8WGD	WAG/WA6	8WGD-mGlu4; mGlu2-WAG/WA6
5.88	Single	8WGD	WAG/WA6	8WGD-mGlu4; mGlu2-WAG/WA6
5.88	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.88	Single	8WPG	Tryptophan; Cinacalcet; PO4; Ca	8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.88	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88	Single	8WPU	Tryptophan; Cinacalcet; PO4; Ca	8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88	Single	8WVX	Norrin	8WVX-LGR4-Norrin
5.88	Single	8WVY	Norrin	8WVY-LGR4-Norrin
5.88	Single	8X0B	Quisqualate	8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.88	Single	8X0B	Quisqualate	8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
5.88	Single	8X0C	Quisqualate	8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
5.88	Single	8X0C	Quisqualate	8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
5.88	Single	8X0D	Quisqualate	8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
5.88	Single	8X0D	Quisqualate	8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
5.88	Single	8X0E	Quisqualate	8X0E-mGlu5; mGlu5-Quisqualate
5.88	Single	8X0E	Quisqualate	8X0E-mGlu5; mGlu5-Quisqualate
5.88	Single	8X0F	Quisqualate	8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
5.88	Single	8X0F	Quisqualate	8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
5.88	Single	8X0G	Quisqualate	8X0G-mGlu5; mGlu5-Quisqualate
5.88	Single	8X0G	Quisqualate	8X0G-mGlu5; mGlu5-Quisqualate
5.88	Single	8X0H	Quisqualate	8X0H-mGlu5; mGlu5-Quisqualate
5.88	Single	8X0H	Quisqualate	8X0H-mGlu5; mGlu5-Quisqualate
5.88	Single	8XUM	R-spondin-2	8XUM-LGR4-R-spondin-2
5.88	Single	9ASB	Ca	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88	Single	9ASB	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88	Single	9AVG	Ca	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.88	Single	9AVG	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.88	Single	9AVL	Ca	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.88	Single	9AVL	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.88	Single	9AVL	Ca	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.88	Single	9AVL	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.88	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88	Single	9AXF	Ca	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88	Single	9AXF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.88	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.88	Single	9B54	A1AIW	9B54-CB₁-A1AIW-Gi1/β1/γ2
5.88	Single	9C1P	Ca	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.88	Single	9C1P	Ca; Tryptophan; '6218; PO4	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.88	Single	9C1P	Ca	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.88	Single	9C1P	Ca; Tryptophan; '6218; PO4	9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.88	Single	9C2F	Ca	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
5.88	Single	9C2F	Ca; Ca; Tryptophan; '6218; PO4	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
5.88	Single	9C2F	Ca	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
5.88	Single	9C2F	Ca; Ca; Tryptophan; '6218; PO4	9C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
5.88	Single	9II2	Glutamate	9II2-mGlu3; mGlu3-Glutamate-Arrestin2
5.88	Single	9II2	Glutamate	9II2-mGlu3; mGlu3-Glutamate-Arrestin2
5.88	Single	9II3	Glutamate	9II3-mGlu3; mGlu3-Glutamate-Arrestin2
5.88	Single	9II3	Glutamate	9II3-mGlu3; mGlu3-Glutamate-Arrestin2
5.71	Single	6NIY	Adrenomedullin	6NIY-CT-Adrenomedullin-Gs/β1/γ2
5.71	Single	6WIV	PubChem 52923113; PubChem 52924645	6WIV-GABA_B1, GABA_B2-PubChem 52923113; PubChem 52924645
5.71	Single	7FIN	Peptide-20; GGL	7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
5.71	Single	7WUI	IP15	7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
5.56	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.56	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.56	Single	7DD6	Ca	7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.56	Single	7DD6	Ca; Ca; Tryptophan	7DD6-CaS-Ca-Ca; Ca; Tryptophan
5.56	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.56	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.56	Single	7DD7	Ca	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.56	Single	7DD7	Ca; Ca; Tryptophan; Evocalcet	7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.56	Single	7TYH	Calcitonin-1	7TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
5.56	Single	9ASB	Ca	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56	Single	9ASB	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56	Single	9AVG	Ca	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.56	Single	9AVG	Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.56	Single	9AYF	Ca	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.56	Single	9AYF	Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4	9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
5.41	Single	7CZ5	Somatoliberin	7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
5.26	Single	6UVA	Adrenomedullin-2	6UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
5.26	Single	7KNU	Calcitonin gene-related peptide-1	7KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
5.26	Single	7T9M	CS-17 Antibody	7T9M-TSH-CS-17 Antibody
5.26	Single	8TLM	Anti-murine CCR8 antibody	8TLM-CCR8-Anti-murine CCR8 antibody
5.13	Single	6PB1	Urocortin	6PB1-CRF₂-Urocortin-chim(NtGi1-Gs)/β1/γ2
5.13	Single	6UUS	Adrenomedullin	6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
5.00	Single	6O3C	Cholesterol	6O3C-SMO-SAG21k-Cholesterol
5.00	Single	6PB0	Urocortin	6PB0-CRF₁-Urocortin-chim(NtGi1-Gs)/β1/γ2
5.00	Single	7FIG	hCG	7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
5.00	Single	7UTZ	TR1402	7UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
5.00	Single	7XW5	TSH	7XW5-TSH-TSH-ML109-Gs/β1/γ2
5.00	Single	7ZI0	Cholesterol	7ZI0-SMO-SAG-Cholesterol
5.00	Single	8WCB	Cyclohexylammonium Ion	8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00	Single	8WCC	Cyclohexylammonium Ion	8WCC-TA1-Cyclohexylammonium Ion
4.76	Single	5L7D	Cholesterol	5L7D-SMO-Cholesterol
4.76	Single	5MZJ	Theophylline	5MZJ-A_2A-Theophylline-Na
4.76	Single	7T9I	TSH	7T9I-TSH-TSH-Gs/β1/γ2
4.76	Single	7WC4	Serotonin	7WC4-5-HT_2A-Serotonin
4.76	Single	8HS2	Fab046	8HS2-GPR20-Fab046
4.76	Single	8I2G	Glycoprotein hormones alpha chain	8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
4.76	Single	8PWN	Theophylline	8PWN-A_2A-Theophylline
4.55	Single	3OE8	IT1t	3OE8-CXCR4-IT1t
4.55	Single	3RFM	Caffeine	3RFM-A_2A-Caffeine
4.55	Single	6TQ9	SB-408124	6TQ9-OX₁-SB-408124
4.35	Single	2J4Y	11-cis-Retinal	2J4Y-Rhodopsin-11-cis-Retinal
4.35	Single	2ZIY	11-cis-Retinal	2ZIY-Rhodopsin-11-cis-Retinal
4.35	Single	6FK9	PubChem 132473036	6FK9-Rhodopsin-PubChem 132473036
4.35	Single	6PWC	Neurotensin	6PWC-NTS₁-Neurotensin-Arrestin2
4.35	Single	7D77	Hydrocortisone	7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
4.35	Single	7F23	Dopamine	7F23-D₁-Dopamine-GDP-Gs/β1/γ2
4.35	Single	7F61	Cholesterol	7F61-H₃-PF-03654746-Cholesterol
4.35	Single	7MT8	All-trans-Retinal	7MT8-Rhodopsin-All-trans-Retinal-GRK1
4.35	Single	7MT9	All-trans-Retinal	7MT9-Rhodopsin-All-trans-Retinal-GRK1
4.35	Single	7MTA	All-trans-Retinal	7MTA-Rhodopsin-All-trans-Retinal-GRK1
4.35	Single	8EIT	Doconexent	8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
4.35	Single	8F76	Propanoic acid	8F76-OR51E2-Propanoic acid-Gs/β1/γ2
4.35	Single	8GGE	Constrained Epinephrine	8GGE-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
4.35	Single	8GGF	Constrained Epinephrine	8GGF-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
4.35	Single	8J21	Butyric acid	8J21-FFA3-Butyric acid-Gi1/β1/γ2
4.35	Single	8J6Q	Beta-Hydroxybutyrate	8J6Q-HCA₂-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
4.35	Single	8WC6	2-Phenylethylamine	8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
4.35	Single	8X9U	Metenolone	8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
4.35	Consensus	ffa3_on	Orthosteric Ligand	8J21-FFA3-Butyric acid-Gi1/β1/γ2
4.35	Consensus	ffa3_on_gp	Orthosteric Ligand	8J21-FFA3-Butyric acid-Gi1/β1/γ2
4.17	Single	5TE5	20-Methanoretinal	5TE5-Rhodopsin-20-Methanoretinal
4.17	Single	6FK6	PubChem 132473033	6FK6-Rhodopsin-PubChem 132473033
4.17	Single	6I9K	9-cis-Retinal	6I9K-Rhodopsin-9-cis-Retinal
4.17	Single	6PGS	Geraniol	6PGS-Rhodopsin-Geraniol-Gt(CT)
4.17	Single	6PH7	Nerol	6PH7-Rhodopsin-Nerol-Gt(CT)
4.17	Single	6QNO	All-trans-Retinal	6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
4.17	Single	7D76	Beclomethasone	7D76-ADGRG3-Beclomethasone-Go/β1/γ2
4.17	Single	7UL2	SR48692	7UL2-NTS₁-SR48692-Na
4.17	Single	7VUI	JNJ-63533054	7VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
4.17	Single	7XKF	Beta-Hydroxyandrosterone	7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
4.17	Single	7XT9	Serotonin	7XT9-5-HT₄-Serotonin-Gs/β1/γ2
4.17	Single	7XTA	Serotonin	7XTA-5-HT₄-Serotonin-Gi1/β1/γ2
4.17	Single	8EF6	Morphine	8EF6-μ-Morphine-Gi1/β1/γ2
4.17	Single	8JLO	Ulotaront	8JLO-TA1-Ulotaront-Gs/β1/γ2
4.17	Single	8JPN	Cis-Epoxysuccinic acid	8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
4.17	Single	8UO3	Constrained Epinephrine	8UO3-β₂-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
4.17	Single	8W89	PEA	8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
4.17	Single	8WP1	Cis-Epoxysuccinic acid	8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
4.17	Single	8YH3	N-methyladenosine	8YH3-A_3A-N-methyladenosine-Gi1/β1/γ2
4.17	Single	8YKW	Succinic acid	8YKW-Succinate-Succinic acid-Gi1/β1/γ1
4.17	Single	8ZSV	RO5263397	8ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
4.17	Consensus	5ht4_on	Orthosteric Ligand	7XTA-5-HT₄-Serotonin-Gi1/β1/γ2
4.17	Consensus	5ht4_on_gp	Orthosteric Ligand	7XTA-5-HT₄-Serotonin-Gi1/β1/γ2
4.17	Consensus	neurotensin_off	Orthosteric Ligand	nts1_off
4.17	Consensus	nts1_off	Orthosteric Ligand	7UL2-NTS₁-SR48692-Na
4.00	Single	2Z73	11-cis-Retinal	2Z73-Rhodopsin-11-cis-Retinal
4.00	Single	3AYN	9-cis-Retinal	3AYN-Rhodopsin-9-cis-Retinal
4.00	Single	6AKY	Maraviroc	6AKY-CCR5-Maraviroc
4.00	Single	6D9H	Adenosine	6D9H-A₁-Adenosine-Gi2/β1/γ2
4.00	Single	6FKB	PubChem 132473038	6FKB-Rhodopsin-PubChem 132473038
4.00	Single	6ME2	Ramelteon	6ME2-MT₁-Ramelteon
4.00	Single	6OYA	All-trans-Retinal	6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
4.00	Single	7F1O	Dopamine	7F1O-D₁-Dopamine-GDP; Mg-Gs/β1/γ2
4.00	Single	7F8U	Lintitript	7F8U-CCK_A-Lintitript
4.00	Single	7F8Y	Devazepide	7F8Y-CCK_A-Devazepide
4.00	Single	7LD4	Adenosine	7LD4-A₁-Adenosine-Gi2/β1/γ2
4.00	Single	7S8P	MS47134	7S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.00	Single	7T6S	PubChem 24776341	7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
4.00	Single	7VUJ	JNJ-63533054	7VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
4.00	Single	7XRR	Lemborexant	7XRR-OX₂-Lemborexant
4.00	Single	7XT8	Serotonin	7XT8-5-HT₄-Serotonin-Gs/β1/γ2
4.00	Single	8DWG	ML382	8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.00	Single	8FYX	Buspirone	8FYX-5-HT_1A-Buspirone-Gi1/β1/γ1
4.00	Single	8GGC	Constrained Epinephrine	8GGC-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
4.00	Single	8HDP	Adenosine	8HDP-A_2B-Adenosine-Gs/β1/γ2
4.00	Single	8J20	Valeric acid	8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
4.00	Single	8JSO	AMPH	8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
4.00	Single	8T3S	Butyric acid	8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.00	Single	8T3V	Docosa-4,7,10,13,16,19-Hexaenoic acid	8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.00	Single	8U8F	Palmitic Acid	8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
4.00	Single	8WC4	ZH8651	8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
4.00	Single	8WCA	2-Phenylethylamine	8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
4.00	Single	8WOG	Succinic acid	8WOG-Succinate-Succinic acid-Gi1/β1/γ2
4.00	Single	8YKX	Maleic acid	8YKX-Succinate-Maleic acid-Gi1/β1/γ1
4.00	Consensus	a1_on	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/β1/γ2
4.00	Consensus	a1_on_gp	Orthosteric Ligand	7LD4-A₁-Adenosine-Gi2/β1/γ2
4.00	Consensus	gi_succinate	Orthosteric Ligand	8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
4.00	Consensus	rhodopsin_on_gp	Orthosteric Ligand	6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
4.00	Consensus	succinate_on	Orthosteric Ligand	8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
4.00	Consensus	succinate_on_gp	Orthosteric Ligand	8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
3.85	Single	1F88	11-cis-Retinal	1F88-Rhodopsin-11-cis-Retinal
3.85	Single	2YDO	Adenosine	2YDO-A_2A-Adenosine
3.85	Single	3UZC	4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol	3UZC-A_2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
3.85	Single	4DKL	Beta-Funaltrexamine	4DKL-μ-β-Funaltrexamine
3.85	Single	4MBS	Maraviroc	4MBS-CCR5-Maraviroc
3.85	Single	6FKA	PubChem 132473037	6FKA-Rhodopsin-PubChem 132473037
3.85	Single	6IQL	L745870	6IQL-D₄-L745870
3.85	Single	6KUX	RS-79948	6KUX-α_2a-RS-79948
3.85	Single	6PEL	Citronellol	6PEL-Rhodopsin-Citronellol-Gt(CT)
3.85	Single	6PS8	2-Phenylmelatonin	6PS8-MT₁-2-Phenylmelatonin
3.85	Single	6ZFZ	77-LH-28-1	6ZFZ-M₁-77-LH-28-1
3.85	Single	6ZG9	GSK1034702	6ZG9-M₁-GSK1034702
3.85	Single	7CKW	Fenoldopam	7CKW-D₁-Fenoldopam-Gs/β1/γ2
3.85	Single	7CKZ	Dopamine	7CKZ-D₁-Dopamine-Mevidalen-Gs/β1/γ2
3.85	Single	7F0T	Dopamine	7F0T-D₁-Dopamine-Gs/β1/γ2
3.85	Single	7F1Z	Dopamine	7F1Z-D₁-Dopamine-GDP-Gs/β1/γ2
3.85	Single	7UL3	Famotidine	7UL3-H₂-Famotidine
3.85	Single	7VOD	Cariprazine	7VOD-5-HT_2A-Cariprazine
3.85	Single	7VUG	JNJ-63533054	7VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
3.85	Single	8GEA	Constrained Epinephrine	8GEA-β₂-Constrained Epinephrine-Gs/β1/γ2
3.85	Single	8GG8	Constrained Epinephrine	8GG8-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
3.85	Single	8GGS	Constrained Epinephrine	8GGS-β₂-Constrained Epinephrine
3.85	Single	8GGT	Constrained Epinephrine	8GGT-β₂-Constrained Epinephrine
3.85	Single	8HJ5	PubChem 139030531	8HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
3.85	Single	8HNM	VUF11222	8HNM-CXCR3-VUF11222-Gi1/β1/γ2
3.85	Single	8HQN	9-S-HODE	8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
3.85	Single	8JLK	Ulotaront	8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
3.85	Single	8K4S	DCA-3P	8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.85	Single	8UHB	RO5256390	8UHB-TA1-RO5256390-Gs/β1/γ2
3.85	Single	8UO0	Constrained Epinephrine	8UO0-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
3.85	Single	8UO1	Constrained Epinephrine	8UO1-β₂-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
3.85	Single	8V6U	PubChem 171392456	8V6U-5-HT_2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
3.85	Single	8VVG	GB18	8VVG-κ-GB18-Gi1/β1/γ2
3.85	Single	8W88	SEP-363856	8W88-TA1-SEP-363856-Gs/β1/γ2
3.85	Single	8WC8	ZH8651	8WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
3.85	Single	8X7A	Treprostinil	8X7A-I2-Treprostinil-Gs/β1/γ2
3.85	Single	8Y45	ADL5859	8Y45-δ-ADL5859-Gi2/β1/γ2
3.85	Single	8YH2	Adenosine	8YH2-A_3A-Adenosine-Gi1/β1/γ2
3.85	Single	8YKV	PubChem 137553168	8YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
3.85	Single	9BJK	Naloxone	9BJK-μ-Naloxone-NAM
3.85	Single	9EPP	11,20-Ethanoretinal	9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
3.85	Single	9JKQ	METH	9JKQ-TA1-METH-Gs/β1/γ2
3.85	Single	9MQI	Isoquinuclidine	9MQI-μ-Isoquinuclidine
3.85	Consensus	5ht2a_off	Orthosteric Ligand	6A94-5-HT_2A-Zotepine 6A93-5-HT_2A-Risperidone 7VOD-5-HT_2A-Cariprazine 7WC8-5-HT_2A-Lumateperone 8JT8-5-HT_2A-(R)-IHCH-7179
3.85	Consensus	ghrelin_off	Orthosteric Ligand	6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
3.85	Consensus	nop_off	Orthosteric Ligand	4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
3.85	Consensus	opsins_off	Orthosteric Ligand	rhodopsin_off
3.85	Consensus	sensory_off	Orthosteric Ligand	opsins_off
3.70	Single	2Y01	Dobutamine	2Y01-β₁-Dobutamine
3.70	Single	2Y02	Carmoterol	2Y02-β₁-Carmoterol
3.70	Single	4EA3	PubChem 10296561	4EA3-NOP-PubChem 10296561
3.70	Single	4QKX	35V	4QKX-β₂-35V
3.70	Single	4X1H	Nonyl-Beta-D-Glucopyranoside	4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
3.70	Single	4YAY	ZD-7155	4YAY-AT₁-ZD-7155
3.70	Single	5DHG	C-35	5DHG-NOP-C-35
3.70	Single	5DHH	SB-612111	5DHH-NOP-SB-612111
3.70	Single	5OLZ	PubChem 135566609	5OLZ-A_2A-PubChem 135566609-Na
3.70	Single	5OM1	PubChem 135566609	5OM1-A_2A-PubChem 135566609-Na
3.70	Single	6DRX	Lisuride	6DRX-5-HT_2B-Lisuride
3.70	Single	6DRZ	Methysergide	6DRZ-5-HT_2B-Methysergide
3.70	Single	6GPS	MK0812	6GPS-CCR2-MK0812
3.70	Single	6IIV	Daltroban	6IIV-TP-Daltroban
3.70	Single	6PS1	Timolol	6PS1-β₂-Timolol
3.70	Single	6TOT	Lemborexant	6TOT-OX₁-Lemborexant
3.70	Single	7BU7	BI167107	7BU7-β₁-BI167107
3.70	Single	7DB6	Ramelteon	7DB6-MT₁-Ramelteon-Gi1/β1/γ2
3.70	Single	7F83	PF-05190457	7F83-Ghrelin-PF-05190457
3.70	Single	7JVQ	Apomorphine	7JVQ-D₁-Apomorphine-Gs/β1/γ2
3.70	Single	7SCG	FH210	7SCG-μ-FH210-Gi1/β1/γ2
3.70	Single	7SQO	TAK-925	7SQO-OX₂-TAK-925-Gi1/β1/γ2
3.70	Single	7T2G	Mitragynine Pseudoindoxyl	7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
3.70	Single	7T6V	fMLFII	7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
3.70	Single	7VH0	Ramelteon	7VH0-MT₂-Ramelteon-Gi1/β1/γ1
3.70	Single	7X2C	Fenoldopam	7X2C-D₁-Fenoldopam-Fenoldopam-Gs/β1/γ2
3.70	Single	8CIC	Etrumadenant	8CIC-A_2A-Etrumadenant-Na
3.70	Single	8GE9	Constrained Epinephrine	8GE9-β₂-Constrained Epinephrine-Gs/β1/γ2
3.70	Single	8GEH	Constrained Epinephrine	8GEH-β₂-Constrained Epinephrine-Gs/β1/γ2
3.70	Single	8IRT	Rotigotine	8IRT-D₃-Rotigotine-Gi1/β1/γ2
3.70	Single	8JLZ	ST1936	8JLZ-5-HT₆-ST1936-Gs/β1/γ2
3.70	Single	8JXR	LSD	8JXR-D₁-LSD
3.70	Single	8KEX	DCA-3P	8KEX-MRGPRX4-DCA-3P
3.70	Single	8KFY	ZK-756326	8KFY-CCR8-ZK-756326-Gi1/β1/γ2
3.70	Single	8T1W	CVN424	8T1W-GPR6-CVN424
3.70	Single	8UNR	Constrained Epinephrine	8UNR-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
3.70	Single	8UNU	Constrained Epinephrine	8UNU-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
3.70	Single	8UNV	Constrained Epinephrine	8UNV-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
3.70	Single	8UNZ	Constrained Epinephrine	8UNZ-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
3.70	Single	8UO2	Constrained Epinephrine	8UO2-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
3.70	Single	8UWL	Lisuride	8UWL-5-HT_2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
3.70	Single	8W87	METH	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
3.70	Single	8W8A	RO5256390	8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
3.70	Single	8X9T	AP503	8X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
3.70	Single	8ZSS	RO5263397	8ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
3.70	Single	9CHX	S-Carazolol	9CHX-β₂-S-Carazolol
3.70	Single	9D61	JDTic	9D61-κ-JDTic-Gi1/β1/γ2
3.70	Single	9IYA	ONO-9710531	9IYA-GPR55-ONO-9710531
3.70	Consensus	5ht2b_off	Orthosteric Ligand	6DRZ-5-HT_2B-Methysergide
3.70	Consensus	5ht6_on	Orthosteric Ligand	7XTB-5-HT₆-Serotonin-Gs/β1/γ2 8JLZ-5-HT₆-ST1936-Gs/β1/γ2
3.70	Consensus	5ht6_on_gp	Orthosteric Ligand	7XTB-5-HT₆-Serotonin-Gs/β1/γ2 8JLZ-5-HT₆-ST1936-Gs/β1/γ2
3.70	Consensus	cck_off	Orthosteric Ligand	ccka_off
3.70	Consensus	ccka_off	Orthosteric Ligand	7F8Y-CCK_A-Devazepide 7F8U-CCK_A-Lintitript
3.70	Consensus	ccr2_off	Orthosteric Ligand	6GPS-CCR2-MK0812
3.70	Consensus	d5_on	Orthosteric Ligand	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2
3.70	Consensus	gi_orexin	Orthosteric Ligand	7SQO-OX₂-TAK-925-Gi1/β1/γ2
3.70	Consensus	gs_trace-amine	Orthosteric Ligand	8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
3.57	Single	4NTJ	AZD1283	4NTJ-P2Y₁₂-AZD1283
3.57	Single	4WW3	All-trans-Retinal	4WW3-Rhodopsin-All-trans-Retinal
3.57	Single	5T1A	PubChem 68764898; PubChem 12093170	5T1A-CCR2-PubChem 68764898; PubChem 12093170
3.57	Single	5WIU	Nemonapride	5WIU-D₄-Nemonapride
3.57	Single	5WIV	Nemonapride	5WIV-D₄-Nemonapride-Na
3.57	Single	5ZBQ	UR-MK-299	5ZBQ-Y₁-UR-MK-299
3.57	Single	5ZK3	3-quinuclidinyl-benzilate	5ZK3-M₂-3-quinuclidinyl-benzilate
3.57	Single	6E67	BI167107	6E67-β₂-BI167107-Gs (fused)
3.57	Single	6GPX	MK0812	6GPX-CCR2-MK0812
3.57	Single	6ME8	2-Phenylmelatonin	6ME8-MT₂-2-Phenylmelatonin
3.57	Single	6RZ4	Pranlukast	6RZ4-CysLT₁-Pranlukast-Na
3.57	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
3.57	Single	6W2X	PubChem 23727970	6W2X-GABA_B1, GABA_B2-PubChem 5311042-PubChem 23727970
3.57	Single	7E9G	JNJ-40411813	7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
3.57	Single	7EPF	NAM597	7EPF-mGlu2; mGlu2-NAM597
3.57	Single	7VOE	Aripiprazole	7VOE-5-HT_2A-Aripiprazole
3.57	Single	7XKA	Constrained Epinephrine	7XKA-β₂-Constrained Epinephrine
3.57	Single	8C9W	Etrumadenant	8C9W-A_2A-Etrumadenant
3.57	Single	8DZQ	momSalB	8DZQ-κ-momSalB-Go/β1/γ2
3.57	Single	8GDZ	Constrained Epinephrine	8GDZ-β₂-Constrained Epinephrine-Gs/β1/γ2
3.57	Single	8GEB	Constrained Epinephrine	8GEB-β₂-Constrained Epinephrine-Gs/β1/γ2
3.57	Single	8GEG	Constrained Epinephrine	8GEG-β₂-Constrained Epinephrine-Gs/β1/γ2
3.57	Single	8GGB	Constrained Epinephrine	8GGB-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
3.57	Single	8J18	(3R)-3-Hydroxydodecanoic acid	8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
3.57	Single	8JGG	BAM8-22	8JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
3.57	Single	8KFX	LMD-009	8KFX-CCR8-LMD-009-Gi1/β1/γ2
3.57	Single	8SZI	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
3.57	Single	8TH4	Losartan	8TH4-AT₁-Losartan-AT118-L Nanobody
3.57	Single	8UNN	Constrained Epinephrine	8UNN-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
3.57	Single	8UNP	Constrained Epinephrine	8UNP-β₂-Constrained Epinephrine-GTP-Gs/β1/γ2
3.57	Single	8XQP	Cholesterol	8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
3.57	Single	8XYK	VUF10661	8XYK-CXCR3-VUF10661-Go1/β1/γ2
3.57	Single	8YH0	NECA	8YH0-A_3A-NECA-Gi1/β1/γ2
3.57	Single	8ZRK	GSK-1292263	8ZRK-GPR119-GSK-1292263-Gs/β1/γ2
3.57	Single	9DQH	EP-2825	9DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57	Single	9DQJ	EP-3945	9DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
3.57	Single	9EAH	Olmesartan	9EAH-AT₁-Olmesartan-Nanobody AT209
3.57	Single	9MQK	Isoquinuclidine	9MQK-κ-Isoquinuclidine
3.57	Consensus	5ht2_off	Orthosteric Ligand	5ht2a_off 5ht2b_off 5ht2c_off
3.57	Consensus	alpha_off	Orthosteric Ligand	alpha1_off alpha2_off
3.57	Consensus	d1_on	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2
3.57	Consensus	gs_amine	Orthosteric Ligand	gs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
3.57	Consensus	ta1_on	Orthosteric Ligand	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.57	Consensus	trace-amine_on	Orthosteric Ligand	ta1_on
3.45	Single	2YDV	NECA	2YDV-A_2A-NECA
3.45	Single	3SN6	BI167107	3SN6-β₂-BI167107-Gs/β1/γ2
3.45	Single	3UON	3-quinuclidinyl-benzilate	3UON-M₂-3-quinuclidinyl-benzilate
3.45	Single	4UHR	CGS21680	4UHR-A_2A-CGS21680
3.45	Single	5A8E	7-Methylcyanopindolol	5A8E-β₁-7-Methylcyanopindolol-Na
3.45	Single	5G53	NECA	5G53-A_2A-NECA-Gs
3.45	Single	5ZBH	BMS-193885	5ZBH-Y₁-BMS-193885
3.45	Single	5ZHP	PubChem 134828589	5ZHP-M₃-PubChem 134828589
3.45	Single	6DDE	Damgo	6DDE-μ-Damgo-Gi1/β1/γ2
3.45	Single	6E59	L-760735	6E59-NK₁-L-760735
3.45	Single	6J20	Aprepitant	6J20-NK₁-Aprepitant
3.45	Single	6KO5	PubChem 57400002	6KO5-Ghrelin-PubChem 57400002
3.45	Single	6N48	BI167107	6N48-β₂-BI167107-PubChem 138454256
3.45	Single	6WGT	LSD	6WGT-5-HT_2A-LSD
3.45	Single	7CKY	PW0464	7CKY-D₁-PW0464-Gs/β1/γ2
3.45	Single	7EW7	SEW2871	7EW7-S1P₁-SEW2871-Gi1/β1/γ2
3.45	Single	7T2H	Lofentanil	7T2H-μ-Lofentanil-Gi1/β1/γ2
3.45	Single	7XY7	NECA	7XY7-A_2B-NECA-chim(NtGi1-Gs)/β1/γ2
3.45	Single	8DCS	Cyanopindolol	8DCS-β₁-Cyanopindolol-Gs/β1/γ2
3.45	Single	8DZP	momSalB	8DZP-κ-momSalB-Gi1/β1/γ2
3.45	Single	8EF5	Fentanyl	8EF5-μ-Fentanyl-Gi1/β1/γ2
3.45	Single	8EFL	SR17018	8EFL-μ-SR17018-Gi1/β1/γ2
3.45	Single	8GDB	PGE2	8GDB-EP₄-PGE2-Gs/β1/γ2
3.45	Single	8IRR	Rotigotine	8IRR-D₁-Rotigotine-Gs/β1/γ2
3.45	Single	8IRV	Rotigotine	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2
3.45	Single	8IUK	PGF2-alpha	8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
3.45	Single	8JLP	Ralmitaront	8JLP-TA1-Ralmitaront-Gs/β1/γ2
3.45	Single	8JXV	Clozapine	8JXV-H₄-Clozapine-Gi1/β1/γ2
3.45	Single	8JXW	VUF6884	8JXW-H₄-VUF6884-Gi1/β1/γ2
3.45	Single	8T1V	PubChem 118310209	8T1V-GPR6-PubChem 118310209-Na
3.45	Single	8X79	MRE-269	8X79-I2-MRE-269-Gs/β1/γ2
3.45	Single	8XJM	Latanoprost	8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
3.45	Single	8XVL	Zibotentan	8XVL-ET_A-Zibotentan
3.45	Single	8ZR5	Firuglipel	8ZR5-GPR119-Firuglipel-Gs/β1/γ2
3.45	Single	9B65	KCA	9B65-CB₁-KCA-Gi1/β1/γ2
3.45	Single	9F33	FOB02-04A	9F33-D₃-FOB02-04A-Go1/β1/γ2
3.45	Consensus	beta2_on	Orthosteric Ligand	7DHI-β₂-Salbutamol-Gs/β1/γ2 6NI3-β₂-BI167107-Gs/β1/γ2
3.45	Consensus	beta2_on_gp	Orthosteric Ligand	7DHI-β₂-Salbutamol-Gs/β1/γ2 6NI3-β₂-BI167107-Gs/β1/γ2
3.45	Consensus	d1_on_gp	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2
3.45	Consensus	d5_on_gp	Orthosteric Ligand	8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2
3.45	Consensus	gi_5ht	Orthosteric Ligand	8FYT-5-HT_1A-LSD-Gi1/β1/γ1 7UM7-5-HT_5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT_1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT_1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT_1A-Serotonin-Gi1/β1/γ2 7E32-5-HT_1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT₄-Serotonin-Gi1/β1/γ2 8UH3-5-HT_1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT_1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT_1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT_1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT_1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT_5A-5-CT-Gi1/β1/γ2 8FY8-5-HT_1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT_1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT_1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT_1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT_5A-Lisuride-chim(NtGi1-Go)/β1/γ2
3.45	Consensus	gs_dopamine	Orthosteric Ligand	7F0T-D₁-Dopamine-Gs/β1/γ2 7CKW-D₁-Fenoldopam-Gs/β1/γ2 7CKY-D₁-PW0464-Gs/β1/γ2 8IRV-D₅-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D₁-Rotigotine-Gs/β1/γ2 7JV5-D₁-SKF81297-Gs/β1/γ2 7JVP-D₁-SKF83959-Gs/β1/γ2 7X2D-D₁-Tavapadon-Gs/β1/γ2 7CKX-D₁-A77636-Gs/β1/γ2 7JVQ-D₁-Apomorphine-Gs/β1/γ2
3.45	Consensus	npy1_off	Orthosteric Ligand	5ZBH-Y₁-BMS-193885 5ZBQ-Y₁-UR-MK-299
3.45	Consensus	npy_off	Orthosteric Ligand	npy1_off npy2_off
3.45	Consensus	ta1_on_gp	Orthosteric Ligand	8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.45	Consensus	tachykinin_off	Orthosteric Ligand	nk1_off
3.45	Consensus	trace-amine_on_gp	Orthosteric Ligand	ta1_on_gp
3.33	Single	2YCX	Cyanopindolol	2YCX-β₁-Cyanopindolol
3.33	Single	4AMI	Bucindolol	4AMI-β₁-Bucindolol
3.33	Single	4LDE	BI167107	4LDE-β₂-BI167107
3.33	Single	5UNH	PubChem 126456406	5UNH-AT₂-PubChem 126456406
3.33	Single	6H7N	S-Xamoterol	6H7N-β₁-S-Xamoterol
3.33	Single	6IIU	Ramatroban	6IIU-TP-Ramatroban
3.33	Single	6W2Y	PubChem 23727970	6W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
3.33	Single	6ZG4	HTL0009936	6ZG4-M₁-HTL0009936
3.33	Single	7DFP	Spiperone	7DFP-D₂-Spiperone
3.33	Single	7EXD	Lasmiditan	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
3.33	Single	7JNI	Olodanrigan	7JNI-AT₂-Olodanrigan
3.33	Single	7MTR	ADX55164	7MTR-mGlu2; mGlu2-Glutamate-ADX55164
3.33	Single	7W0L	PubChem 122701908	7W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
3.33	Single	7WCM	MBX-2982	7WCM-GPR119-MBX-2982-Gs/β1/γ2
3.33	Single	7XMT	J-2156	7XMT-SST4-J-2156-Gi1/β1/γ2
3.33	Single	7YIT	Nalfurafine	7YIT-κ-Nalfurafine
3.33	Single	8IQ6	Latanoprost	8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
3.33	Single	8SZH	Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW	8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
3.33	Single	8VHF	MBX-2982	8VHF-GPR119-MBX-2982-Gs/β1/γ2
3.33	Single	8XJN	Cloprosetnol	8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
3.33	Single	8XYI	VUF10661	8XYI-CXCR3-VUF10661
3.33	Consensus	5ht1f_on	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
3.33	Consensus	5ht1f_on_gp	Orthosteric Ligand	7EXD-5-HT_1F-Lasmiditan-Gi1/β1/γ2
3.33	Consensus	nk1_off	Orthosteric Ligand	6HLP-NK₁-Netupitant 6HLO-NK₁-Aprepitant 6HLL-NK₁-CP99994 6E59-NK₁-L-760735
3.33	Consensus	opioid_off	Orthosteric Ligand	mop_off nop_off dop_off kop_off
3.23	Single	2YCZ	Iodocyanopindolol	2YCZ-β₁-Iodocyanopindolol
3.23	Single	4BVN	Cyanopindolol	4BVN-β₁-Cyanopindolol-Na
3.23	Single	6DDF	Damgo	6DDF-μ-Damgo-Gi1/β1/γ2
3.23	Single	6K1Q	IRL2500	6K1Q-ET_B-IRL2500
3.23	Single	7MTS	ADX55164	7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
3.23	Single	7SK7	CCX662	7SK7-ACKR3-CXCL12-CCX662
3.23	Single	7SK8	CCX662	7SK8-ACKR3-CXCL12-CCX662
3.23	Single	7UM4	AS2674723	7UM4-5-HT_5A-AS2674723
3.23	Single	7VGY	2-Iodomelatonin	7VGY-MT₁-2-Iodomelatonin-Gi1/β1/γ2
3.23	Single	7VVN	PTH	7VVN-PTH1-PTH-Gs/β1/γ2
3.23	Single	7X2D	Tavapadon	7X2D-D₁-Tavapadon-Gs/β1/γ2
3.23	Single	7XZ6	APD668	7XZ6-GPR119-APD668-Gs/β1/γ2
3.23	Single	8E9X	2-Deoxycytidine	8E9X-M₄-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
3.23	Single	8FX5	Xanomeline	8FX5-M₄-Xanomeline-Xanomeline-Gi1/β1/γ2
3.23	Single	8IJD	MK6892	8IJD-HCA₂-MK6892-Gi1/β1/γ2
3.23	Single	8T3O	TUG-891	8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.23	Single	8XGS	Metastin	8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
3.23	Single	8XJK	Cloprosetnol	8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23	Single	8XJO	U46619	8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23	Single	9EAI	Losartan	9EAI-AT₁-Losartan-Nanobody AT209
3.23	Consensus	endothelin_off	Orthosteric Ligand	etb_off
3.23	Consensus	etb_off	Orthosteric Ligand	5X93-ET_B-K-8794 5XPR-ET_B-Bosentan 6K1Q-ET_B-IRL2500
3.23	Consensus	peptide_off	Orthosteric Ligand	cck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
3.23	Consensus	prostanoid_on	Orthosteric Ligand	tp_on fp-alpha_on
3.23	Consensus	prostanoid_on_gp	Orthosteric Ligand	tp_on_gp fp-alpha_on_gp
3.23	Consensus	tp_on	Orthosteric Ligand	8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
3.23	Consensus	tp_on_gp	Orthosteric Ligand	8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
3.12	Single	5EE7	MK0893	5EE7-Glucagon-MK0893
3.12	Single	6PT3	DPI-287	6PT3-δ-DPI-287
3.03	Single	7QA8	Peptide	7QA8-STE2-Peptide
3.03	Single	7QA8	Peptide	7QA8-STE2-Peptide
3.03	Single	8PKM	Befiradol	8PKM-5-HT_1A-Befiradol-t7m-Gi1/β1/γ1
3.03	Single	8XFT	R-spondin-2	8XFT-LGR4-R-spondin-2-ZNRF3
3.03	Single	8Y69	R-spondin-2	8Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
2.94	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
2.94	Single	7CUM	Phospholipid	7CUM-GABA_B1, GABA_B2-CGP54626-Phospholipid
2.86	Single	8WVU	R-spondin-1	8WVU-LGR4-R-spondin-1-RNF43
2.86	Single	8Y69	R-spondin-2	8Y69-LGR4-R-spondin-2-Cholesterol-ZNRF3
2.78	Single	8XFP	R-spondin-2	8XFP-LGR4-R-spondin-2-ZNRF3
2.70	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-α-factor mating pheromone
2.63	Single	6P9Y	PACAP	6P9Y-PAC₁-PACAP-Gs/β1/γ2
2.63	Single	7QBI	Alpha-factor mating pheromone	7QBI-STE2-α-factor mating pheromone
2.56	Single	6P9X	Corticoliberin	6P9X-CRF₁-Corticoliberin-Gs/β1/γ2
2.56	Single	7AD3	Alpha-factor mating pheromone	7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
2.56	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-α-factor mating pheromone
2.56	Single	8XFS	R-spondin-2	8XFS-LGR4-R-spondin-2-ZNRF3
2.50	Single	7QBC	Alpha-factor mating pheromone	7QBC-STE2-α-factor mating pheromone

Consensus Members
	Id	Members
	7VLA	7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2

Net Summary
I_min	3.65
Number of Linked Nodes	284
Number of Links	322
Number of Hubs	36
Number of Links mediated by Hubs	160
Number of Communities	6
Number of Nodes involved in Communities	59
Number of Links involved in Communities	82

Path Summary
Number Of Nodes in MetaPath	73
Number Of Links MetaPath	72
Number of Shortest Paths	99783
Length Of Smallest Path	3
Average Path Length	18.5716
Length of Longest Path	41
Minimum Path Strength	1.22
Average Path Strength	6.85756
Maximum Path Strength	22.3067
Minimum Path Correlation	0.7
Average Path Correlation	0.938143
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.125
Average % Of Corr. Nodes	46.0503
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.194
Maximum Path Hubs %	100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
	Id	Components
	ccr_on	ccr6_on ccr8_on ccr2_on ccr1_on ccr5_on

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download ccr1_on.zip

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