Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.S1.02 5565
2G.S1.06 3.855408
3G.S1.07 4.09409
4G.H1.04 2.8575407
5G.S2.05 10.2275413
6G.S2.08 5.985465
7G.S3.03 7.4575467
8G.S3.04 8.905616
9G.S3.06 10.258515
10G.S3.07 6.68409
11G.s3h2.03 6.93419
12G.H2.06 7.736519
13G.H2.07 7.398519
14G.H2.08 4.52418
15G.h2s4.01 5.24667619
16G.S4.02 3.82418
17G.S4.04 5.4225109
18G.s4h3.03 6.784158
19G.s4h3.04 6.45167698
20G.H3.09 7.63254109
21G.H3.12 3.4925418
22G.H3.13 4.85754105
23G.H3.18 5.6925419
24G.S5.04 4.11254109
25G.S5.05 5.992509
26G.HG.03 4.9525496
27G.HG.04 7.5675499
28G.HG.07 6.89499
29G.hgh4.05 5.62507
30G.S6.02 5.91254177
31G.H5.04 3.4525407
32G.H5.08 5.665468
33G.H5.11 3.598568
34G.H5.20 3.818509
35G.H5.21 4.9085165
36b.lh12x2 7.48754188
37b.h2x5 4.1275405
38b.b1x6 8.83409
39b.l1x3 8.09167689
40b.l1x7 4.715489
41b.b2x1 5.5175418
42b.b2x5 6.53571737
43b.b4x3 4.724507
44b.b4x6 9.01689
45b.l4x2 12.5475434
46b.b5x3 6.57589
47b.b5x5 4.9925405
48b.b5x7 5.328507
49b.l5x1 4.395408
50b.b6x5 5.256506
51b.l6x5 5.47414
52b.b7x1 4.506514
53b.l7x2 4.24333619
54b.b8x3 4.2275416
55b.b8x4 6.158506
56b.l9x3 7.0725419
57b.l9x6 5.118518
58b.b10x3 3.382518
59b.b10x5 5.016519
60b.l10x1 3.85403
61b.l10x3 6.035416
62b.b11x2 4.39517
63b.b11x4 4.88333619
64b.b11x6 7.77419
65b.b12x3 4.235458
66b.b12x6 8.632518
67b.b13x7 6.784557
68b.l13x3 5.79167659
69b.l13x6 5.66519
70b.l13x7 4.74459
71b.b15x1 6.76659
72b.b15x2 8.17446
73b.b15x3 5.105459
74b.l15x1 4.745417
75b.l15x2 6.0525409
76b.b16x4 7.034556
77b.b16x5 6.945405
78b.b16x6 7.61658
79b.b17x7 7.535448
80b.l17x3 10.455649
81b.b18x3 3.854548
82b.l18x1 7.98429776
83b.l18x2 5.6675477
84b.b19x2 7.72833646
85b.b19x4 7.0375448
86b.l19x2 3.95409
87b.b20x2 5.646546
88b.b20x4 13.5925448
89b.b20x6 7.6425446
90b.l20x2 7.985409
91b.b21x1 9.52447
92b.b21x5 5.32404
93b.b22x5 4.83714777
94b.l22x5 8.8625119
95b.b23x2 4.27576
96b.b23x6 6.9256147
97b.b24x4 9.49754146
98b.b24x6 8.9725148
99b.b24x7 7.6654119
100b.l24x3 4.6325115
101b.l25x3 7.7065139
102b.l25x6 11.315408
103b.b26x3 4.9075406
104b.l27x1 10.425619
105b.b28x4 9.9454136
106b.b28x5 5.098535
107b.b28x6 8.875139
108g.h1x8 5.455407
109g.l1x4 4.92408
110g.h2x11 10.245476
111g.ctx3 6.451676199
112g.ctx5 5.35754199
113g.ctx6 4.0125406
114g.ctx14 5.66439
115g.ctx15 7.1725439
116g.ctx16 6.14667638
117Lig 40.98422420
1181x39 4.52333627
1191x53 4.31254228
1201x57 2.6675406
1212x42 5.19507
1222x44 2.8405
123E1x50 6.99167629
124E1x52 3.98606
1253x25 5.0725429
1263x33 7.565405
1273x37 4.4875407
1283x50 8.46409
1293x51 7.8954127
1303x55 6.25754127
1313x56 6.15754126
132I2x52 6.418564
133I2x57 5.94236
1344x65 6.954524
135E2x52 5.0675425
136E2.L191 5.54405
1375x36 7.46424
1385x40 6.965425
1395x47 5.17408
1405x58 8.5765128
1415x61 3.634128
142I3.M234 4.948504
1436x37 5.92254127
1446x48 7.988509
1456x55 8.3425426
1466x61 3.088501
1476x62 7.3425422
148E3.I273 5.0254264
1497x42 6.4225427
1507x45 6.4225409
1517x49 7.705409
1527x50 3.835409
1537x53 5.556509
1548x50 6.8985228
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.b3x6 b.l3x2 12.06747.36NoNo099
2b.b4x2 b.l3x2 12.28886.91NoNo089
3b.b4x2 b.b5x8 12.51875.02NoNo085
4b.b5x7 b.b5x8 12.63463.39YesNo075
5b.b4x3 b.b5x7 14.85385.71YesYes077
6b.b3x5 b.b4x3 18.91194.73NoYes097
7b.b3x5 b.b6x3 19.02831.81NoNo098
8b.b2x2 b.b6x3 19.14591.81NoNo078
9b.b26x2 b.b2x2 19.26681.81NoNo077
10b.b26x1 b.b26x2 19.38833.44NoNo097
11b.b26x1 b.l27x1 19.50994.94NoYes099
12b.b2x1 b.l27x1 40.87522.89YesYes189
13G.H2.10 b.b2x1 41.22285.38NoYes178
14G.H2.10 b.l7x2 41.32693.17NoYes179
15b.l5x5 b.l7x2 79.31733.42NoYes199
16G.S3.06 b.l5x5 79.307519.04YesNo159
17G.S2.03 G.S3.06 49.84411.66NoYes195
18G.S2.03 G.S2.05 49.874712.31NoYes193
19G.H1.11 G.S2.05 99.973110.61NoYes073
20G.H1.09 G.H1.11 99.97992.91NoNo077
21G.H1.09 G.S2.04 99.98663NoNo076
22G.S2.04 G.S3.05 99.99334.52NoNo067
23G.S1.06 G.S3.05 1005.65YesNo087
24G.S1.06 G.S4.03 74.56082.85YesNo087
25G.S1.04 G.S4.03 49.45495.71NoNo077
26G.H5.11 G.S1.04 48.78532.98YesNo687
27G.H5.11 G.H5.15 48.92433.07YesNo687
28G.H5.15 I2x52 24.70043.76NoYes674
29G.S3.04 G.S3.06 49.91484.96YesYes165
30G.S2.05 G.S3.04 49.983114.41YesYes136
31G.H1.04 G.S1.06 25.56152.85YesYes078
32G.H2.04 G.H2.07 10.70367NoYes099
33G.H2.04 G.H3.08 10.57793.64NoNo099
34G.H3.08 G.S4.04 10.46014.87NoYes099
35G.H1.04 G.S5.05 25.28733.77YesYes079
36G.S4.03 G.S5.05 25.2583.77NoYes079
37b.l7x2 b.l9x6 44.92643.52YesYes198
38b.l13x6 b.l9x6 17.68654.6YesYes198
39b.l13x6 b.l15x1 17.0924.67YesYes197
40b.l23x1 b.l25x6 20.492516.68NoYes068
41b.l21x7 b.l23x1 20.25474.67NoNo056
42b.l21x7 b.l23x2 20.13614.67NoNo058
43b.b23x6 b.l23x2 19.54035.75YesNo078
44b.b23x6 b.b24x6 18.706311.58YesYes1478
45b.b21x7 b.b24x6 18.15038.68NoYes058
46b.b21x5 b.b21x7 14.84763.59YesNo045
47b.b21x5 b.h2x2 12.62024.6YesNo041
48b.h2x2 b.l24x3 12.50173.06NoYes015
49G.S5.03 G.S5.05 48.73843.77NoYes089
50G.HG.15 G.hgh4.05 10.902710.55NoYes077
51G.H4.11 G.HG.15 14.21552.85NoNo077
52G.H4.11 G.H4.15 14.68852.51NoNo078
53G.H5.10 G.S5.03 48.56844.87NoNo068
54G.H5.10 G.S6.02 48.4846.67NoYes067
55G.H5.13 G.S6.02 48.217510.34NoYes1787
56G.H5.13 I3.M234 48.146511.09NoYes084
57G.H5.16 I3.M234 47.72592.92NoYes064
58G.H5.16 G.H5.20 47.55812.85NoYes069
59G.H5.15 G.H5.19 24.20244.25NoNo678
603x53 G.H5.19 24.16753.13NoNo088
61G.H5.20 G.H5.25 35.75334.15YesNo097
623x54 G.H5.20 10.22322.85NoYes089
637x49 7x50 12.4083.26YesYes099
642x46 3x42 19.46754.15NoNo097
653x42 3x45 19.55343.17NoNo2475
662x42 3x45 19.75075.38YesNo075
672x42 3x49 47.77855.75YesNo078
683x49 I2x57 47.84978.3NoYes2386
693x53 I2x57 24.09593.21NoYes086
707x49 7x53 11.4325.81YesYes099
713x50 7x53 39.87036.17YesYes099
723x46 3x50 27.74886.26NoYes089
732x42 3x46 27.83887.25YesNo078
74I2x55 I2x57 24.23734.5NoYes056
75I2x52 I2x55 24.273111.64YesNo045
763x50 G.H5.25 27.610912.15YesNo097
77b.b10x1 b.l9x6 20.53336.36NoYes098
78b.b10x1 b.b11x5 20.41153.26NoNo096
79b.b11x5 b.l13x7 12.98533.23NoYes069
80b.b17x3 g.h1x10 12.64733.05NoNo059
81g.h1x10 g.h1x14 12.1428.92NoNo099
82g.h1x11 g.h1x14 11.63676.63NoNo099
83b.1x11 g.h1x11 10.62595.54NoNo089
84b.l15x1 b.l17x6 16.7366.22YesNo179
85b.l17x5 b.l17x6 16.48587.36NoNo169
86b.l17x5 b.l19x2 16.36565.89NoYes069
87b.b19x4 b.l17x3 11.42988.21YesYes489
885x36 Lig 14.90613.49YesYes240
895x36 E2x52 15.52293.49YesYes245
904x61 E2x52 19.01754.66NoYes245
913x33 4x61 20.80310.49YesNo054
923x33 3x36 35.65784.66YesNo057
933x36 6x48 38.89348.02NoYes079
946x48 7x45 40.93756.35YesYes099
953x43 7x45 41.50493.86NoYes089
962x46 3x43 14.04114.15NoNo098
973x43 7x53 27.76595.86NoYes089
985x40 Lig 19.54843.49YesYes250
995x40 5x44 19.95193.39YesNo256
1005x44 6x52 22.314511.48NoNo068
1015x47 6x52 22.70569.67YesNo088
1025x47 5x51 26.62142.44YesNo086
1035x51 6x44 27.40742.44NoNo069
1045x54 6x44 27.77794.98NoNo089
1053x47 5x54 28.16563.07NoNo098
1063x47 5x58 29.292913.99NoYes098
1073x50 5x58 15.30729.26YesYes098
1083x32 3x33 12.506610.8NoYes065
1096x58 Lig 11.048811.26NoYes250
1106x58 7x30 10.36184.2NoNo054
111G.S3.06 G.h2s4.01 20.41343.22YesYes159
112G.H2.07 G.h2s4.01 10.45365.01YesYes199
113b.l25x6 b.l27x1 20.96622.99YesYes089
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
E2.S184Lig4.892NoYes5010
7x35Lig6.912NoYes4010
7x38Lig9.452NoYes6010
5x36Lig3.492YesYes4010
5x40Lig3.492YesYes5010
6x58Lig11.262NoYes5010
6x62Lig12.112YesYes2010
7x34Lig3.982NoYes4010
E2x51Lig16.412NoYes4010
7x27Lig17.062NoYes1010
LigNT.P29102YesNo0301
LigNT.D2611.062YesNo0701
LigNT.Y2720.232YesNo0401
LigNT.P229.192YesNo0601
LigNT.P214.792YesNo0301
E2.N181Lig3.970NoYes3010
E2.N193Lig5.960NoYes3010
E2.Y178Lig152NoYes2010
LigNT.S287.192YesNo0501
NT.D24NT.D2617.32NoNo6721
NT.D24NT.Y275.752NoNo6421
NT.E25NT.S288.620NoNo2521
NT.D26NT.Y275.752NoNo7411
7x27NT.L324.862NoNo1212
2x647x354.152NoNo5421
E1x49E2.S1843.710NoNo5521
E2.P180E2.Y17813.910NoNo3221
E2.V190E2.Y1785.050NoNo4221
E2.P185E2.S1843.560NoNo4521
5x36E2x5116.462YesNo4411
5x36E2x523.492YesYes4512
5x365x406.42YesYes4511
5x376x624.960NoYes3221
5x405x443.392YesNo5612
5x406x5514.582YesYes5612
5x446x556.432NoYes6622
6x557x344.152YesNo6421
6x586x629.532NoYes5211
6x587x304.22NoNo5412
7x387x4210.492NoYes6712
LigNT.A232.772YesNo0301
5x336x622.770NoYes1221
LigNT.T341.62YesNo0501
6x547x341.490NoNo5421
E2.N182Lig1.210NoYes7010

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
81.82Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
68.75Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
66.67Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
66.67Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
64.71Single8XWNCXCL88XWN-CXCR2-CXCL8
62.50Single8XVUCXCL28XVU-CXCR2-CXCL2
62.50Single8XWFCXCL38XWF-CXCR2-CXCL3
62.50Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
60.00Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
58.82Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
57.89Single3OE0CVX153OE0-CXCR4-CVX15
57.14Single4QIMANTA XV4QIM-SMO-ANTA XV
56.25Single8XWACXCL18XWA-CXCR2-CXCL1
56.25Single8XWMCXCL68XWM-CXCR2-CXCL6
56.25Single8XWSCXCL58XWS-CXCR2-CXCL5
53.85Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
53.85Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
53.33Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
53.33Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
52.94Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
52.94Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
52.94Single8ZPLHF511168ZPL-CXCR4-HF51116
52.63Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
50.00Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
50.00Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
47.37Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
46.67Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
46.15Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
45.83Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
45.83Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
45.83Consensusbradykinin_onOrthosteric Ligandbk2_on
45.83Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
45.83Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
45.45Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
45.45Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
45.45Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
45.45Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
44.44Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
43.75Single4JKVTaladegib4JKV-SMO-Taladegib
43.75Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
43.75Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
43.48Single7SK3CXCL127SK3-ACKR3-CXCL12
42.31Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
42.11Single6KNMJN241-96KNM-Apelin-JN241-9
42.11Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
42.11Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
41.67Consensusp2y_offOrthosteric Ligandp2y1_off
41.18Single5V56TC1145V56-SMO-TC114
41.18Single5V57TC1145V57-SMO-TC114
41.18Single6OS1TRV0266OS1-AT1-TRV026
40.91Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
40.91Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
40.00Single7T94LY21196207T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
40.00Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
40.00Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
40.00Single8ZPNAMD31008ZPN-CXCR4-AMD3100
40.00Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
40.00Consensusendothelin_onOrthosteric Ligandetb_on eta_on
40.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
40.00Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
39.13Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
38.89Single6OS2TRV0266OS2-AT1-TRV026
38.89Single8XQJJN2418XQJ-Apelin-JN241
38.46Single4XNWMRS25004XNW-P2Y1-MRS2500
38.46Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
38.46Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
38.10Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
38.10Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
37.50Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
37.50Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
37.50Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
37.50Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
37.50Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
37.50Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
37.50Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
37.50Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
37.04Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
36.84Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
36.84Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
36.36Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
36.36Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
36.36Single9M1OMorphine-Modulating Neuropeptide B9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
36.36Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
36.36Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
36.36Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
36.36Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
36.00Single9KDFRES-701-39KDF-ETB-RES-701-3
35.71Single4O9RCyclopamine4O9R-SMO-Cyclopamine
35.71Single5L7IVismodegib5L7I-SMO-Vismodegib
35.71Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
35.71Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
35.29Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.29Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
35.29Single8ZYTNeurotensin peptide 8-138ZYT-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
35.29Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
35.29Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
35.00Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
35.00Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
35.00Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
35.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
35.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
35.00Single8XQJJN2418XQJ-Apelin-JN241
35.00Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
35.00Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
34.78Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
34.78Single6JODAngiotensin II6JOD-AT2-Angiotensin II
34.78Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
34.78Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
34.78Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
34.78Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
34.78Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
34.62Single8IY6Endothelin-18IY6-ETB-Endothelin-1
33.33Single3PWHZM-2413853PWH-A2A-ZM-241385
33.33Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
33.33Single4QINSAG1.54QIN-SMO-SAG1.5
33.33Single5GLHEndothelin-15GLH-ETB-Endothelin-1
33.33Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
33.33Single7F1TMIP-1a7F1T-CCR5-MIP-1a
33.33Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
33.33Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
33.33Single7PX4PSB-21137PX4-A2A-PSB-2113
33.33Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
33.33Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
33.33Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
33.33Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
33.33Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
33.33Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
33.33Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
33.33Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
33.33Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
33.33Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
33.33Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
33.33Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
33.33Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
33.33Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
33.33Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
33.33Single8U4PAMD31008U4P-CXCR4-AMD3100-Gi1/β1/γ2
33.33Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
33.33Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
33.33Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
33.33Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
33.33Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
33.33Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
33.33Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
33.33Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
33.33Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
33.33Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
33.33Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
33.33Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
33.33Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
33.33Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
33.33Consensuslpa_onOrthosteric Ligandlpa1_on
33.33Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
33.33Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
33.33Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
33.33Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
32.00Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
32.00Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
32.00Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
32.00Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
32.00Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
32.00Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
32.00Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
32.00Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
32.00Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
31.82Single3QAKUK-4320973QAK-A2A-UK-432097
31.82Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
31.82Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
31.82Single7SK5CXCL127SK5-ACKR3-CXCL12
31.82Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
31.82Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
31.82Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
31.82Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
31.82Single9KFIRelaxin-39KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
31.82Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
31.58Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
31.58Single4PY02MeSATP4PY0-P2Y12-2MeSATP
31.58Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
31.58Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
31.58Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
31.58Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
31.58Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
31.58Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
31.58Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
31.58Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
31.58Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
31.58Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
31.58Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
31.58Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
31.25Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
31.25Single5IUBQ274563445IUB-A2A-Q27456344-Na
31.25Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
31.25Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
31.25Single6AQFZM-2413856AQF-A2A-ZM-241385
31.25Single6MH8ZM-2413856MH8-A2A-ZM-241385
31.25Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
31.25Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
31.25Single7AROLUF58337ARO-A2A-LUF5833-Na
31.25Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
31.25Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
31.25Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
31.25Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
31.03Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
30.77Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
30.77Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
30.77Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
30.77Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
30.43Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
30.43Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
30.43Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.43Consensusangiotensin_onOrthosteric Ligandat1_on
30.43Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
30.43Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
30.43Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
30.00Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
30.00Single7EZCUKA7EZC-A2A-UKA
30.00Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
30.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
30.00Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
30.00Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
30.00Single8JPFNeurotensin8JPF-NTS1-Neurotensin-SBI-553
30.00Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
30.00Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
29.63Single6IGLIRL16206IGL-ETB-IRL1620
29.41Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
29.41Single5IU8Q274563475IU8-A2A-Q27456347-Na
29.41Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
29.41Single5UENDU1725UEN-A1-DU172
29.41Single6D27CAY104716D27-DP2-CAY10471
29.41Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
29.41Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
29.41Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
29.41Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
29.41Single7PYRPSB-21157PYR-A2A-PSB-2115
29.41Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
29.41Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
29.41Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
29.41Consensusa3_onOrthosteric Liganda3a_on
29.17Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
29.17Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
29.17Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
29.17Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
29.17Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
29.17Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
29.17Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
29.17Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
28.57Single5WF6UK-4320975WF6-A2A-UK-432097
28.57Single6IGKEndothelin-36IGK-ETB-Endothelin-3
28.57Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
28.57Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
28.57Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
28.57Single8JPSCCL78JPS-ACKR1-CCL7
28.57Single8QJ2pN1628QJ2-MC4-pN162-Gs
28.57Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
28.57Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
28.57Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
28.57Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
28.00Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
28.00Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
28.00Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
27.78Single5IUAQ274563485IUA-A2A-Q27456348-Na
27.78Single5N2RPSB-365N2R-A2A-PSB-36-Na
27.78Single5N2SPSB365N2S-A1-PSB36
27.78Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
27.78Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
27.78Single6S0QZM-2413856S0Q-A2A-ZM-241385
27.78Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
27.78Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
27.78Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
27.78Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
27.78Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
27.78Single8GNEKW-63568GNE-A2A-KW-6356-Na
27.78Single8QOTNanobody-E8QOT-μ-Nanobody-E
27.78Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
27.78Consensusa3_on_gpOrthosteric Liganda3a_on_gp
27.78Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
27.78Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
27.78Consensusadenosine_offOrthosteric Liganda1_off a2_off
27.78Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
27.78Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
27.78Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
27.78Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
27.78Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
27.59Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
27.27Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
27.27Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
27.27Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
27.27Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
27.27Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
27.27Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single9BUYLM1899BUY-β2-LM189-Gi1/β1/γ2
27.27Single9HB3Mambaquaretin-19HB3-V2-Mambaquaretin-1
27.27Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
27.27Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
27.27Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
27.27Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
26.92Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
26.92Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
26.67Single6LI0C176LI0-GPR52-C17
26.67Single7UL2SR486927UL2-NTS1-SR48692-Na
26.67Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
26.67Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
26.67Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.67Single9LMPNE52-QQ579LMP-GPR4-NE52-QQ57
26.67Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
26.67Consensusneurotensin_offOrthosteric Ligandnts1_off
26.67Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
26.32Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
26.32Single4BV0Neurotensin4BV0-NTS1-Neurotensin
26.32Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
26.32Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
26.32Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
26.32Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
26.32Single7R0CAVP7R0C-V2-AVP-Arrestin2
26.32Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
26.32Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
26.32Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
26.32Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
26.32Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
26.32Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
26.32Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
26.32Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
26.32Single9IK9SST analogue9IK9-SST1-SST analogue-Gi1/β1/γ2
26.32Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
26.32Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Consensusneurotensin_onOrthosteric Ligandnts1_on
26.32Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
26.32Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
26.09Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
26.09Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
26.09Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
26.09Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
26.09Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
26.09Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
26.09Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
26.09Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
26.09Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
26.09Single9E82SDF-1-beta9E82-ACKR3-SDF-1-β-Arrestin2
26.09Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
26.09Single9IQRMuscarinic toxin 39IQR-α2a-Muscarinic toxin 3
26.09Single9IQSMuscarinic toxin 39IQS-M4-Muscarinic toxin 3
26.09Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
26.09Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
26.09Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
25.93Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
25.93Single8W8XBeta-MSH8W8X-MC3-β-MSH-Ca-Gs/β1/γ2
25.93Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
25.93Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
25.93Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
25.93Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
25.93Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
25.00Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
25.00Single4BWBNeurotensin4BWB-NTS1-Neurotensin
25.00Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
25.00Single4RWADIPP-NH24RWA-δ-DIPP-NH2
25.00Single4XEENeurotensin4XEE-NTS1-Neurotensin
25.00Single4XESNeurotensin4XES-NTS1-Neurotensin
25.00Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
25.00Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
25.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
25.00Single5WF5UK-4320975WF5-A2A-UK-432097
25.00Single5ZKQABT-4915ZKQ-PAF-ABT-491
25.00Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
25.00Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
25.00Single6MXTSalmeterol6MXT-β2-Salmeterol
25.00Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
25.00Single6YVRNTS8-136YVR-NTS1-NTS8-13
25.00Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
25.00Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
25.00Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
25.00Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
25.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
25.00Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
25.00Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
25.00Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
25.00Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
25.00Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
25.00Single8GNGIstradefylline8GNG-A2A-Istradefylline
25.00Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
25.00Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
25.00Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
25.00Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
25.00Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
25.00Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
25.00Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
25.00Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
25.00Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
25.00Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
25.00Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
25.00Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.00Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
25.00Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
25.00Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
25.00Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
25.00Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
25.00Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
25.00Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
25.00Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
25.00Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
25.00Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
25.00Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
25.00Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
25.00Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
25.00Consensuslpa_offOrthosteric Ligandlpa1_off
25.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
25.00Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
25.00Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
25.00Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
25.00Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
25.00Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
25.00Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
25.00Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
24.00Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
24.00Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
24.00Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
24.00Single8ZBISomatostatin-148ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
24.00Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
24.00Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
24.00Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
24.00Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
24.00Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
24.00Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
24.00Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
24.00Consensusvasop-oxy_onOrthosteric Ligandv2_on
24.00Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
23.81Single4BUONeurotensin4BUO-NTS1-Neurotensin
23.81Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
23.81Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
23.81Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
23.81Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
23.81Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
23.81Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
23.81Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
23.81Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
23.81Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
23.81Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
23.81Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
23.81Consensuscck_onOrthosteric Ligandccka_on cckb_on
23.81Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
23.81Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
23.81Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
23.81Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
23.81Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
23.53Single3REYXAC3REY-A2A-XAC
23.53Single5IU7Q274563465IU7-A2A-Q27456346-Na
23.53Single5JTBZM-2413855JTB-A2A-ZM-241385
23.53Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
23.53Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
23.53Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
23.53Single7F61PF-036547467F61-H3-PF-03654746
23.53Single7T32ZM-2413857T32-A2A-ZM-241385
23.53Single7UTZDPPC7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
23.53Single7VV6C48/807VV6-MRGPRX2-C48/80
23.53Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
23.53Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
23.53Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
23.53Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
23.53Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
23.53Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
23.53Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
23.53Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
23.53Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
23.53Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
23.53Single8ZPMAMD0708ZPM-CXCR4-AMD070
23.53Single9BA0A1AKN9BA0-CB1-A1AKN
23.53Single9JFUNE52-QQ579JFU-GPR4-NE52-QQ57
23.53Single9M2FNeuropeptide FF9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
23.53Consensusa2_offOrthosteric Liganda2a_off
23.53Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
23.53Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
23.53Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
23.33Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
23.33Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
23.33Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
23.08Single7V68LY21196207V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
23.08Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
23.08Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
23.08Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
23.08Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
23.08Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
23.08Single8ZRTET-18ZRT-ETB-ET-1
23.08Single9JFYhNPSF9JFY-NPFF2-hNPSF-Gi1/β1/γ2
23.08Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
23.08Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
22.73Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
22.73Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
22.73Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
22.73Single7XN9L-054,5227XN9-SST2-L-054,522
22.73Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
22.73Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
22.73Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
22.73Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
22.73Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single9M0RNeuropeptide VF9M0R-NPFF1-Neuropeptide VF-Gi1/β1/γ2
22.73Single9V2NMacimorelin9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
22.73Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
22.22Single3EMLZM-2413853EML-A2A-ZM-241385
22.22Single4XT3Fractalkine4XT3-US28-Fractalkine
22.22Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
22.22Single5T04Neurotensin5T04-NTS1-Neurotensin
22.22Single5UIGCmpd-15UIG-A2A-Cmpd-1
22.22Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
22.22Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
22.22Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
22.22Single6S0LZM-2413856S0L-A2A-ZM-241385
22.22Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
22.22Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
22.22Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
22.22Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
22.22Single8CU6LJ-45178CU6-A2A-LJ-4517
22.22Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
22.22Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
22.22Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
22.22Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
22.22Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
22.22Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
22.22Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
22.22Single9H37A1IR09H37-A2A-A1IR0-Na
22.22Single9KFKRelaxin-39KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
22.22Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
22.22Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
22.22Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
22.22Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
22.22Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
22.22Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
21.74Single4IARErgotamine4IAR-5-HT1B-Ergotamine
21.74Single4XT1Fractalkine4XT1-US28-Fractalkine
21.74Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
21.74Single7F8XNN90567F8X-CCKA-NN9056
21.74Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
21.74Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
21.74Single8WDTphotoNECA8WDT-A2A-photoNECA
21.74Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
21.74Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
21.74Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
21.74Consensuslpl_onOrthosteric Ligands1p_on lpa_on
21.74Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
21.74Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
21.74Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
21.43Single3RFMCaffeine3RFM-A2A-Caffeine
21.43Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
21.43Single8A2OTheophylline8A2O-A2A-Theophylline-Na
21.43Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
21.43Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
21.43Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
21.43Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
21.05Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
21.05Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
21.05Single6D26Fevipiprant6D26-DP2-Fevipiprant
21.05Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
21.05Single6Z4SSR486926Z4S-NTS1-SR48692
21.05Single7C61Ergotamine7C61-5-HT1B-Ergotamine
21.05Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
21.05Single7LD3Adenosine7LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
21.05Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
21.05Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
21.05Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
21.05Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
21.05Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
21.05Single8S4DCMF-0198S4D-Apelin-CMF-019
21.05Single8TF5Oleic acid8TF5-GPR6-Oleic acid
21.05Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
21.05Single8WGBVU01550418WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
21.05Single9B9ZA1AKO9B9Z-CB1-A1AKO
21.05Single9CIBFCH-22964139CIB-HCA2-FCH-2296413
21.05Single9EHSLUF76029EHS-A3A-LUF7602
21.05Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
21.05Single9GE2ML1849GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
21.05Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
21.05Consensusdp_offOrthosteric Liganddp2_off
21.05Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
21.05Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
21.05Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
21.05Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
20.83Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
20.83Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
20.83Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
20.83Single7XNACYN1548067XNA-SST2-CYN154806
20.83Single8IEBA1LYA8IEB-GPR156-A1LYA
20.83Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
20.83Single9IQVMuscarinic toxin 39IQV-Alpha1A-Muscarinic toxin 3
20.83Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
20.83Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
20.83Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
20.83Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
20.00Single3OE6IT1t3OE6-CXCR4-IT1t
20.00Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
20.00Single5TZRMK86665TZR-FFA1-MK8666
20.00Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
20.00Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
20.00Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
20.00Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
20.00Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
20.00Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
20.00Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
20.00Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
20.00Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
20.00Single7TUYGSK682753A7TUY-GPR183-GSK682753A
20.00Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
20.00Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
20.00Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
20.00Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
20.00Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
20.00Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
20.00Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
20.00Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
20.00Single8W8YGamma-MSH8W8Y-MC3-γ-MSH-Ca-Gs/β1/γ2
20.00Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
20.00Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
20.00Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.00Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.00Single8Y73Peptide8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
20.00Consensusa2_onOrthosteric Liganda2b_on
20.00Consensusa2_on_gpOrthosteric Liganda2b_on_gp
20.00Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
20.00Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
20.00Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
20.00Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
20.00Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
20.00Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
20.00Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
20.00Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
20.00Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
20.00Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
20.00Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
20.00Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
20.00Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
20.00Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
20.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
20.00Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
19.23Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
19.23Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
19.23Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
19.23Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
19.23Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
19.23Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.23Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
19.23Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
19.05Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
19.05Single4N4WSANT-14N4W-SMO-SANT-1
19.05Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
19.05Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
19.05Single6A93Risperidone6A93-5-HT2A-Risperidone
19.05Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
19.05Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
19.05Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
19.05Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
19.05Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
19.05Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.05Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
19.05Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
19.05Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.05Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
19.05Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
19.05Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
19.05Single8JJLOlodaterol8JJL-β2-Olodaterol
19.05Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
19.05Single8JWY2-1188JWY-A2A-2-118
19.05Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
19.05Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
19.05Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
19.05Single9CM3TUG-13759CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.05Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
19.05Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
19.05Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
19.05Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
18.75Single3OE9IT1t3OE9-CXCR4-IT1t
18.75Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.75Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
18.75Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
18.75Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
18.75Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
18.75Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
18.75Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
18.75Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
18.75Single8ZYUNeurotensin peptide 8-138ZYU-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
18.75Single9B9Y7DY9B9Y-CB1-7DY
18.75Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg4_on
18.75Consensusadgrg_on_gpOrthosteric Ligandadgrg2_on_gp adgrg4_on_gp
18.75Consensusgq_nucleotideOrthosteric Ligandgq_p2y
18.75Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
18.52Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
18.52Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
18.52Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
18.52Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
18.52Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
18.18Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
18.18Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
18.18Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
18.18Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.18Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
18.18Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
18.18Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
18.18Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
18.18Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
18.18Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single9M54Neuropeptide VF9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
18.18Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
18.18Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.18Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
18.18Consensusprostanoid_offOrthosteric Ligandep_off dp_off
17.86Single6FJ3PTH6FJ3-PTH1-PTH
17.86Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
17.86Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
17.86Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
17.65Single3ODUIT1t3ODU-CXCR4-IT1t
17.65Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
17.65Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
17.65Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
17.65Single5U09Taranabant5U09-CB1-Taranabant
17.65Single6DS0Ly2660976DS0-5-HT2B-Ly266097
17.65Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
17.65Single7BR3Elagolix7BR3-GnRH1-Elagolix
17.65Single7F8ULintitript7F8U-CCKA-Lintitript
17.65Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
17.65Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
17.65Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
17.65Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
17.65Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.65Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
17.65Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
17.65Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
17.65Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
17.65Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
17.65Single9H2XA1IR19H2X-A2A-A1IR1-Na
17.65Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
17.65Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
17.65Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
17.65Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
17.65Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
17.39Single3NY9ICI118-5513NY9-β2-ICI118-551
17.39Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
17.39Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
17.39Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
17.39Single6PT3DPI-2876PT3-δ-DPI-287
17.39Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
17.39Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
17.39Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
17.39Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
17.39Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.39Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
17.39Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
17.39Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
17.39Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
17.39Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
17.39Single9CM7TUG-13759CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
17.39Single9IZASCH9002719IZA-HCA2-SCH900271-Gi1/β1/γ2
17.39Single9NS9TUG-13759NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
17.39Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
17.39Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
17.39Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
17.24Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
17.24Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
17.14Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
17.14Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
16.67Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
16.67Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
16.67Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
16.67Single5UVIZM-2413855UVI-A2A-ZM-241385
16.67Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
16.67Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
16.67Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
16.67Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
16.67Single6ZINSR486926ZIN-NTS1-SR48692
16.67Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
16.67Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
16.67Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
16.67Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
16.67Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
16.67Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
16.67Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
16.67Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
16.67Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
16.67Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
16.67Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
16.67Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
16.67Single8IEBA1LYA8IEB-GPR156-A1LYA
16.67Single8IEIA1LYA8IEI-GPR156-A1LYA
16.67Single8IEPA1LYA8IEP-GPR156-A1LYA
16.67Single8IEPA1LYA8IEP-GPR156-A1LYA
16.67Single8IHKAcifran8IHK-HCA3-Acifran
16.67Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
16.67Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
16.67Single8K2WAMG4878K2W-CXCR3-AMG487
16.67Single8K5CAcipimox8K5C-HCA2-Acipimox
16.67Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
16.67Single8WKYPG-9348WKY-MC4-PG-934
16.67Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
16.67Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single8Y6YGLPG09748Y6Y-FFA2-GLPG0974
16.67Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
16.67Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
16.67Single8ZBJSomatostatin-148ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
16.67Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
16.67Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single9JH3CMF-0199JH3-Apelin-CMF-019-Gi1/β1/γ2
16.67Single9JMDAzithromycin9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
16.67Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Gi1/β1/γ2
16.67Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
16.67Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
16.67Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
16.67Consensusgrh_offOrthosteric Ligandgnrh1_off
16.67Consensushca_onOrthosteric Ligandhca2_on
16.67Consensuspth1_onOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
16.67Consensussomatostatin_offOrthosteric Ligandsst2_off
16.00Single6HLOAprepitant6HLO-NK1-Aprepitant
16.00Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
16.00Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
16.00Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
16.00Single9IK8SST analogue9IK8-SST1-SST analogue-Gi1/β1/γ2
16.00Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
16.00Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
16.00Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
16.00Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
16.00Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
16.00Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
16.00Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
15.79Single4EJ4Naltrindole4EJ4-δ-Naltrindole
15.79Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
15.79Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
15.79Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
15.79Single5TGZAM65385TGZ-CB1-AM6538
15.79Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
15.79Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
15.79Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
15.79Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
15.79Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
15.79Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
15.79Single7V3ZCP559407V3Z-CB1-CP55940
15.79Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
15.79Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
15.79Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
15.79Single7YXAONO-54306087YXA-S1P5-ONO-5430608
15.79Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
15.79Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.79Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
15.79Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
15.79Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
15.79Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
15.79Single8ZYYNeurotensin peptide 8-138ZYY-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
15.79Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
15.79Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
15.79Single9IZCMK19039IZC-HCA2-MK1903-Gi1/β1/γ2
15.79Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
15.79Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
15.79Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
15.79Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
15.79Consensushca_on_gpOrthosteric Ligandhca2_on_gp
15.62Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
15.38Single6PT2KGCHM076PT2-δ-KGCHM07
15.38Single6W25SHU91196W25-MC4-SHU9119-Ca
15.38Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
15.38Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
15.38Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
15.38Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
15.38Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
15.38Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
15.38Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
15.38Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
15.38Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
15.15Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
15.15Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
15.00Single4NTJAZD12834NTJ-P2Y12-AZD1283
15.00Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
15.00Single5C1MBU725C1M-μ-BU72
15.00Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
15.00Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
15.00Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
15.00Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
15.00Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
15.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
15.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
15.00Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
15.00Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
15.00Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
15.00Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
15.00Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
15.00Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
15.00Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
15.00Single7W41PD1762527W41-BB2-PD176252
15.00Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.00Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.00Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
15.00Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
15.00Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
15.00Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
15.00Single9EE8Adenosine9EE8-A2A-Adenosine-Gs/β1/γ2
15.00Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
15.00Consensusadgrg2_onOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
15.00Consensusadgrg2_on_gpOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
15.00Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
15.00Consensusbombesin_offOrthosteric Ligandbb2_off
15.00Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
15.00Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
15.00Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
15.00Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
15.00Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
15.00Consensusep_offOrthosteric Ligandep4_off
15.00Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
15.00Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
14.81Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
14.81Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
14.81Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
14.81Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
14.81Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
14.81Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
14.81Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
14.81Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
14.81Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
14.81Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
14.81Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
14.63Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
14.29Single3P0GBI1671073P0G-β2-BI167107
14.29Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
14.29Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
14.29Single5XR8AM8415XR8-CB1-AM841
14.29Single5XRAAM115425XRA-CB1-AM11542
14.29Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
14.29Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
14.29Single6J21Aprepitant6J21-NK1-Aprepitant
14.29Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
14.29Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
14.29Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
14.29Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
14.29Single7FEECP559407FEE-CB1-CP55940-ZCZ011
14.29Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
14.29Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
14.29Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
14.29Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
14.29Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
14.29Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
14.29Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
14.29Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
14.29Single8E0GBU728E0G-μ-BU72
14.29Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
14.29Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
14.29Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
14.29Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
14.29Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
14.29Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
14.29Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
14.29Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
14.29Single8PWNTheophylline8PWN-A2A-Theophylline
14.29Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
14.29Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
14.29Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
14.29Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
14.29Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
14.29Single8ZW0PGD28ZW0-DP1-PGD2-Gs/β1/γ2
14.29Single8ZWFJR14a8ZWF-C3aB-JR14a
14.29Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
14.29Single9BJKNaloxone9BJK-μ-Naloxone-NAM
14.29Single9CLWTUG-13759CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Single9EGOYVF9EGO-CB1-YVF-Gi1/β1/γ2
14.29Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
14.29Single9JMCDS-3801b9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
14.29Single9UY3Anamorelin9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
14.29Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
14.29Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
14.29Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
14.29Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
14.29Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
14.29Consensuspac_onOrthosteric Ligandpac1_on
14.29Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
14.29Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
14.29Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
13.79Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
13.79Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
13.79Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
13.79Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
13.79Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
13.79Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
13.79Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
13.79Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
13.79Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
13.79Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
13.79Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
13.79Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
13.64Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
13.64Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
13.64Single6CM4Risperidone6CM4-D2-Risperidone
13.64Single6KQICP559406KQI-CB1-CP55940-Org27569
13.64Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
13.64Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
13.64Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
13.64Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
13.64Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
13.64Single7K15MKD0467K15-BLT1-MKD046-Na
13.64Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
13.64Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
13.64Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
13.64Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
13.64Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
13.64Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
13.64Single7YITNalfurafine7YIT-κ-Nalfurafine
13.64Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
13.64Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
13.64Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
13.64Single8JJ8Formoterol8JJ8-β2-Formoterol
13.64Single8JWZAB9288JWZ-A2A-AB928-Na
13.64Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
13.64Single9DGIZ85267113509DGI-CB1-Z8526711350
13.64Single9EBIPiclidenoson9EBI-A3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
13.64Single9GGGI-BOP9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.64Single9M4QDoxazosin9M4Q-Alpha1A-Doxazosin
13.64Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
13.64Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
13.64Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
13.64Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
13.64Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
13.64Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
13.64Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
13.64Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
13.64Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
13.64Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
13.64Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
13.64Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
13.64Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
13.64Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
13.51Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
13.33Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
13.33Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
13.33Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
13.33Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
13.33Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
13.33Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
13.33Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
13.33Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
13.33Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
13.33Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
13.33Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
13.33Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
13.33Single8W8WAlpha-MSH8W8W-MC3-α-MSH-Ca-Gs/β1/γ2
13.33Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single9EE9Adenosine9EE9-A2A-Adenosine-Gs/β1/γ2
13.33Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
13.33Consensusglp_onOrthosteric Ligandglp1_on glp2_on
13.33Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
13.33Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
13.04Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
13.04Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
13.04Single6IBLArformoterol6IBL-β1-Arformoterol
13.04Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
13.04Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
13.04Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
13.04Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
13.04Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
13.04Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
13.04Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
13.04Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
13.04Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
13.04Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
13.04Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
13.04Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
13.04Single8T3OTUG-8918T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
13.04Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
13.04Single9CGJC6-Quino9CGJ-δ-C6-Quino-Gi1/β1/γ2
13.04Single9GG5U466199GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single9JH5C16:0 Ceramide9JH5-CysLT2-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Single9M1HProstaglandin E29M1H-EP1-Prostaglandin E2-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
13.04Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
13.04Consensuschemerin_onOrthosteric Ligandcml1_on
13.04Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
13.04Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
13.04Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
13.04Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
12.90Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
12.90Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
12.90Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
12.90Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
12.90Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
12.90Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
12.90Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
12.90Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
12.90Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
12.90Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
12.90Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
12.90Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
12.90Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
12.90Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
12.90Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
12.90Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
12.90Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
12.50Single3UZAGTPL92363UZA-A2A-GTPL9236
12.50Single4UG2CGS216804UG2-A2A-CGS21680
12.50Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
12.50Single6ME5Agomelatine6ME5-MT1-Agomelatine
12.50Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
12.50Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
12.50Single7WC5Psilocin7WC5-5-HT2A-Psilocin
12.50Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
12.50Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
12.50Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
12.50Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
12.50Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
12.50Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.50Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
12.50Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
12.50Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
12.50Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
12.50Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
12.50Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
12.50Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
12.50Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
12.50Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
12.50Single8Y72Peptide8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
12.50Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
12.50Single9CGKC5-Quino9CGK-δ-C5-Quino-Gi1/β1/γ2
12.50Single9IPVJR14a9IPV-C3aB-JR14a-Gi1/β1/γ2
12.50Single9IPYJR14a9IPY-C3aB-JR14a
12.50Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
12.50Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single9JHJC18:0 Ceramide9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
12.50Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
12.50Consensuscrf1_onOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
12.50Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
12.50Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
12.50Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
12.50Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
12.50Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
12.50Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
12.12Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
12.12Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
12.12Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
12.12Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
12.00Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
12.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
12.00Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
12.00Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
12.00Single8IEIA1LYA8IEI-GPR156-A1LYA
12.00Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
12.00Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
12.00Single8KIGSHU91198KIG-MC3-SHU9119-Ca
12.00Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
12.00Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
12.00Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
11.76Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
11.76Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
11.76Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
11.76Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
11.76Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
11.76Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
11.76Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
11.76Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
11.76Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
11.76Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
11.76Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
11.76Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
11.76Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
11.76Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
11.76Single8K5BNiacin8K5B-HCA2-Niacin
11.76Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
11.76Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
11.76Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
11.76Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
11.76Single9IZDCHBA9IZD-HCA1-CHBA-Gi1/β1/γ2
11.76Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.76Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
11.76Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
11.76Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
11.54Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
11.54Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
11.54Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
11.54Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
11.54Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
11.54Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
11.43Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
11.43Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
11.43Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
11.43Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
11.43Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
11.43Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.43Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
11.43Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
11.43Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
11.11Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
11.11Single6AKYMaraviroc6AKY-CCR5-Maraviroc
11.11Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
11.11Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
11.11Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
11.11Single6ME9Ramelteon6ME9-MT2-Ramelteon
11.11Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
11.11Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
11.11Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
11.11Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
11.11Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
11.11Single7F8YDevazepide7F8Y-CCKA-Devazepide
11.11Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
11.11Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
11.11Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
11.11Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
11.11Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
11.11Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
11.11Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
11.11Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
11.11Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
11.11Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
11.11Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
11.11Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.11Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
11.11Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
11.11Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
11.11Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
11.11Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
11.11Single9B5YLong-Acting PTH9B5Y-PTH1-Long-Acting PTH-chim(NtGi1-Gq)/β1/γ2
11.11Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
11.11Single9EBHAdenosine9EBH-A3A-Adenosine-Gi1/β1/γ2
11.11Single9EEAAdenosine9EEA-A2A-Adenosine-Gs/β1/γ2
11.11Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
11.11Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
11.11Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
11.11Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
11.11Consensuspth_onOrthosteric Ligandpth1_on pth2_on
10.81Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
10.71Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
10.71Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
10.71Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
10.71Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
10.71Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
10.71Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
10.71Single9BLCCagrilintide backbone (non-acylated)9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
10.71Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
10.71Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
10.53Single2YDOAdenosine2YDO-A2A-Adenosine
10.53Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
10.53Single4MBSMaraviroc4MBS-CCR5-Maraviroc
10.53Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
10.53Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
10.53Single6KUXRS-799486KUX-α2a-RS-79948
10.53Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
10.53Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
10.53Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
10.53Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
10.53Single7UL3Famotidine7UL3-H2-Famotidine
10.53Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
10.53Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
10.53Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
10.53Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
10.53Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
10.53Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
10.53Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
10.53Single8K9LDamgo8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
10.53Single8RLNLUF58348RLN-A2A-LUF5834
10.53Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.53Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
10.53Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
10.53Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
10.53Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
10.53Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
10.53Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
10.53Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
10.53Single9IXXLTD49IXX-CysLT2-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
10.53Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
10.53Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
10.34Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
10.34Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
10.34Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
10.34Consensuscalcitonin_onOrthosteric Ligandctlike_on
10.34Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
10.00Single2Y01Dobutamine2Y01-β1-Dobutamine
10.00Single2Y02Carmoterol2Y02-β1-Carmoterol
10.00Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
10.00Single6DRXLisuride6DRX-5-HT2B-Lisuride
10.00Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
10.00Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
10.00Single6GPSMK08126GPS-CCR2-MK0812
10.00Single6IIVDaltroban6IIV-TXA2-Daltroban
10.00Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
10.00Single6PS1Timolol6PS1-β2-Timolol
10.00Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
10.00Single7BU7BI1671077BU7-β1-BI167107
10.00Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
10.00Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
10.00Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
10.00Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
10.00Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
10.00Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
10.00Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
10.00Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
10.00Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
10.00Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
10.00Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
10.00Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
10.00Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
10.00Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
10.00Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
10.00Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
10.00Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
10.00Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
10.00Single8JXRLSD8JXR-D1-LSD
10.00Single8K5DGSK2560738K5D-HCA2-GSK256073
10.00Single8T1WCVN4248T1W-GPR6-CVN424
10.00Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
10.00Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
10.00Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
10.00Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
10.00Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
10.00Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
10.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
10.00Single9BLBCagrilintide backbone (non-acylated)9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
10.00Single9BLWCagrilintide backbone (non-acylated)9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
10.00Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
10.00Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
10.00Single9CHXS-Carazolol9CHX-β2-S-Carazolol
10.00Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
10.00Single9JGKBalovaptan9JGK-5-HT2B-Balovaptan
10.00Single9KFJPubChem 1383196749KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
10.00Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
10.00Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
10.00Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
10.00Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
10.00Consensusblt_onOrthosteric Ligandblt1_on
10.00Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
10.00Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
10.00Consensuscck_offOrthosteric Ligandccka_off
10.00Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
10.00Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
10.00Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
10.00Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
10.00Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
10.00Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
10.00Consensusleukotriene_onOrthosteric Ligandblt_on
10.00Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
10.00Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
10.00Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
10.00Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
9.68Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
9.68Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
9.68Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
9.68Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
9.68Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
9.68Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
9.68Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
9.68Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
9.52Single2Y00Dobutamine2Y00-β1-Dobutamine
9.52Single5T1ABMS-6815T1A-CCR2-BMS-681-PubChem 12093170
9.52Single5X7DS-Carazolol5X7D-β2-S-Carazolol-Cmpd-15
9.52Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
9.52Single6E67BI1671076E67-β2-BI167107-Gs(CT)
9.52Single6GPXMK08126GPX-CCR2-MK0812
9.52Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
9.52Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
9.52Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
9.52Single7C4SS1P7C4S-S1P3-S1P
9.52Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
9.52Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
9.52Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
9.52Single7SINNPS-21437SIN-CaS-NPS-2143
9.52Single7SINNPS-21437SIN-CaS-NPS-2143
9.52Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
9.52Single7WC6LSD7WC6-5-HT2A-LSD
9.52Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
9.52Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
9.52Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
9.52Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
9.52Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
9.52Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
9.52Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
9.52Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
9.52Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
9.52Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
9.52Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
9.52Single8JXSPF-61428JXS-D1-PF-6142
9.52Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
9.52Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
9.52Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.52Single8XYKVUF106618XYK-CXCR3-VUF10661-Go/β1/γ2
9.52Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
9.52Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
9.52Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
9.52Single9F34FOB02-04A9F34-D3-FOB02-04A-Go/β1/γ2
9.52Single9HAPTolvaptan9HAP-V2-Tolvaptan
9.52Single9I52A1IZU9I52-D1-A1IZU-Gs/β1/γ2
9.52Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
9.52Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
9.52Consensusblt_offOrthosteric Ligandblt1_off
9.52Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
9.52Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
9.52Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
9.52Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.52Consensustrace-amine_onOrthosteric Ligandta1_on
9.38Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
9.38Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
9.38Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
9.38Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
9.38Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
9.38Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
9.38Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
9.38Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
9.09Single2YDVNECA2YDV-A2A-NECA
9.09Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
9.09Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
9.09Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
9.09Single4UHRCGS216804UHR-A2A-CGS21680
9.09Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
9.09Single5G53NECA5G53-A2A-NECA-Gs
9.09Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
9.09Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
9.09Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
9.09Single6D35Cholesterol6D35-SMO-Cholesterol
9.09Single6E59L-7607356E59-NK1-L-760735
9.09Single6J20Aprepitant6J20-NK1-Aprepitant
9.09Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
9.09Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
9.09Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
9.09Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
9.09Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
9.09Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
9.09Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
9.09Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042
9.09Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
9.09Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
9.09Single6WGTLSD6WGT-5-HT2A-LSD
9.09Single7B6WCyclazosin7B6W-α1b-Cyclazosin
9.09Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-BHFF
9.09Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
9.09Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626
9.09Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
9.09Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
9.09Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
9.09Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
9.09Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
9.09Single7DTTCa7DTT-CaS-Ca-Ca
9.09Single7DTTCa7DTT-CaS-Ca-Ca
9.09Single7DTUTryptophan7DTU-CaS-Tryptophan
9.09Single7DTUTryptophan7DTU-CaS-Tryptophan
9.09Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
9.09Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
9.09Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
9.09Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
9.09Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
9.09Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
9.09Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
9.09Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
9.09Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
9.09Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
9.09Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
9.09Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
9.09Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
9.09Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
9.09Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
9.09Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
9.09Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
9.09Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
9.09Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
9.09Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
9.09Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
9.09Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
9.09Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
9.09Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
9.09Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
9.09Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
9.09Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
9.09Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
9.09Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.09Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.09Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.09Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.09Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
9.09Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
9.09Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
9.09Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
9.09Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
9.09Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
9.09Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
9.09Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
9.09Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
9.09Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
9.09Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
9.09Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
9.09Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
9.09Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
9.09Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
9.09Single7T9NM22 Fab7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
9.09Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
9.09Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
9.09Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
9.09Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
9.09Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
9.09Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
9.09Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
9.09Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
9.09Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
9.09Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
9.09Single7XW7K1-707XW7-TSH-K1-70
9.09Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
9.09Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
9.09Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
9.09Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
9.09Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
9.09Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
9.09Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
9.09Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
9.09Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
9.09Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
9.09Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
9.09Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
9.09Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
9.09Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
9.09Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
9.09Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
9.09Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
9.09Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
9.09Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
9.09Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
9.09Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
9.09Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
9.09Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
9.09Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
9.09Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
9.09Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
9.09Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
9.09Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
9.09Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
9.09Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
9.09Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
9.09Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
9.09Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
9.09Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
9.09Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
9.09Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
9.09Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
9.09Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
9.09Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
9.09Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
9.09Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
9.09Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
9.09Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
9.09Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
9.09Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
9.09Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
9.09Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
9.09Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
9.09Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
9.09Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
9.09Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
9.09Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
9.09Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
9.09Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
9.09Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
9.09Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
9.09Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
9.09Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
9.09Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
9.09Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
9.09Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
9.09Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single8WVXNorrin8WVX-LGR4-Norrin
9.09Single8WVYNorrin8WVY-LGR4-Norrin
9.09Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
9.09Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
9.09Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
9.09Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
9.09Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
9.09Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
9.09Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
9.09Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
9.09Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
9.09Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
9.09Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
9.09Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
9.09Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
9.09Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
9.09Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
9.09Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
9.09Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
9.09Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
9.09Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
9.09Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
9.09Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
9.09Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
9.09Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
9.09Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
9.09Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
9.09Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
9.09Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
9.09Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
9.09Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
9.09Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
9.09Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
9.09Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
9.09Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
9.09Single9KHHNorrin9KHH-LGR4-Norrin
9.09Single9S37NB219S37-LGR4-NB21
9.09Single9UTBSucralose9UTB-TAS1R2; TAS1R3-Sucralose
9.09Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
9.09Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
9.09Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
9.09Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
9.09Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
9.09Consensustachykinin_offOrthosteric Ligandnk1_off
9.09Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
8.82Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
8.82Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
8.82Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
8.70Single4AMIBucindolol4AMI-β1-Bucindolol
8.70Single4LDEBI1671074LDE-β2-BI167107
8.70Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
8.70Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
8.70Single5X33BIIL2605X33-BLT1-BIIL260
8.70Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
8.70Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
8.70Single6IIURamatroban6IIU-TXA2-Ramatroban
8.70Single7DFPSpiperone7DFP-D2-Spiperone
8.70Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
8.70Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
8.70Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
8.70Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
8.70Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.70Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
8.70Single8XJNCloprosetnol8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
8.70Single8XYIVUF106618XYI-CXCR3-VUF10661
8.70Single9AU0BW245C9AU0-DP1-BW245C-Gs/β1/γ2
8.70Single9BJKNAM9BJK-μ-Naloxone-NAM
8.70Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
8.70Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
8.70Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
8.70Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
8.70Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
8.70Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
8.70Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
8.70Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
8.70Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
8.70Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
8.70Consensusorexin_onOrthosteric Ligandox2_on
8.70Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
8.70Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.70Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
8.33Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
8.33Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
8.33Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
8.33Single6H7LDobutamine6H7L-β1-Dobutamine
8.33Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
8.33Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
8.33Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
8.33Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
8.33Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
8.33Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
8.33Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
8.33Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
8.33Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
8.33Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
8.33Single7UM4AS26747237UM4-5-HT5A-AS2674723
8.33Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
8.33Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
8.33Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
8.33Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
8.33Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
8.33Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
8.33Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
8.33Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
8.33Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single8XJOU466198XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single8ZWGJR14a8ZWG-C3aB-JR14a-Gi1/β1/γ2
8.33Single9AS02-bromo-LSD9AS0-5-HT2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
8.33Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
8.33Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
8.33Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
8.33Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
8.33Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
8.33Consensusclass-b2_onOrthosteric Ligandadgrg_on adgrf_on adgrl_on adgre_on adgrd_on
8.33Consensusclass-b2_on_gpOrthosteric Ligandadgrg_on_gp adgrf_on_gp adgrl_on_gp adgre_on_gp adgrd_on_gp
8.33Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
8.33Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
8.33Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
8.33Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
8.33Consensustp_onOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Consensustp_on_gpOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single5ZTYAM102575ZTY-CB2-AM10257
8.00Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
8.00Single7SK9CCX6627SK9-ACKR3-CCX662
8.00Single8X5YAstemizole8X5Y-H1-Astemizole
8.00Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
8.00Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
8.00Single9JF4PD1683689JF4-BB1-PD168368
8.00Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
7.69Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
7.69Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
7.69Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
7.69Single7QA8Peptide7QA8-STE2-Peptide
7.69Single7QA8Peptide7QA8-STE2-Peptide
7.69Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
7.69Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
7.69Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
7.69Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
7.69Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
7.69Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
7.69Single9M4TSilodosin9M4T-Alpha1A-Silodosin
7.50Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
7.32Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
7.14Single5MZPCaffeine5MZP-A2A-Caffeine-Na
7.14Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
7.14Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
7.14Single7UTZTR14027UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
7.14Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
7.14Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
7.14Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
7.14Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
7.14Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
6.90Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
6.90Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
6.90Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
6.67Single5L7DCholesterol5L7D-SMO-Cholesterol
6.67Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
6.67Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
6.67Single7WC4Serotonin7WC4-5-HT2A-Serotonin
6.67Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
6.67Single8HS2Fab0468HS2-GPR20-Fab046
6.67Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
6.67Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
6.45Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
6.45Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
6.45Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
6.25Single3OE8IT1t3OE8-CXCR4-IT1t
6.25Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
6.25Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
6.25Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
6.25Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
6.25Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
6.25Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
6.25Single8Y02Retinal8Y02-OPN1SW-Retinal-Gi1/β1/γ2
6.25Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
6.25Single9CHUNoradrenaline9CHU-β2-Noradrenaline
6.06Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
6.06Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
5.88Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
5.88Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
5.88Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
5.88Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
5.88Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.88Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
5.88Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
5.88Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
5.88Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
5.88Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
5.88Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
5.88Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
5.88Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.88Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
5.88Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
5.88Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
5.88Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
5.88Single9LRCHistamine9LRC-H4-Histamine
5.88Single9LREHistamine9LRE-H4-Histamine-Gi1/β1/γ2
5.88Consensus5ht2_onOrthosteric Ligand5ht2b_on
5.88Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
5.88Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
5.88Consensusbombesin_onOrthosteric Ligandbb2_on
5.88Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
5.88Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.88Consensusgi_sensoryOrthosteric Ligandgi_opsins
5.88Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
5.88Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
5.88Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
5.88Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.88Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
5.56Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
5.56Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
5.56Single6HLLCP999946HLL-NK1-CP99994
5.56Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
5.56Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
5.56Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
5.56Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
5.56Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
5.56Single7SRQLSD7SRQ-5-HT2B-LSD
5.56Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
5.56Single7XP6Strychnine7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
5.56Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
5.56Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
5.56Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
5.56Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
5.56Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
5.56Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
5.56Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
5.56Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
5.56Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
5.56Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
5.56Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
5.56Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
5.56Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
5.56Single8YN7Immethridine8YN7-H3-Immethridine-Go/β1/γ2
5.56Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
5.56Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
5.56Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
5.56Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
5.56Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
5.26Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
5.26Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
5.26Single4S0VSuvorexant4S0V-OX2-Suvorexant
5.26Single5WS3EMPA5WS3-OX2-EMPA
5.26Single6AKXA4R6AKX-CCR5-A4R
5.26Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
5.26Single6ME2Ramelteon6ME2-MT1-Ramelteon
5.26Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
5.26Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
5.26Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
5.26Single6TODEMPA6TOD-OX1-EMPA-Na
5.26Single6TPJSuvorexant6TPJ-OX2-Suvorexant
5.26Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
5.26Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
5.26Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
5.26Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
5.26Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
5.26Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
5.26Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
5.26Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.26Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
5.26Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
5.26Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
5.26Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
5.26Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
5.26Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
5.26Single7XRRLemborexant7XRR-OX2-Lemborexant
5.26Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
5.26Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
5.26Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
5.26Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
5.26Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
5.26Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
5.26Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
5.26Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
5.26Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
5.26Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
5.26Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
5.26Single8IWESpermidine8IWE-TA9-Spermidine
5.26Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
5.26Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.26Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
5.26Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
5.26Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.26Single8Y0HVUF114188Y0H-CXCR3-VUF11418
5.26Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go/β1/γ2
5.26Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
5.26Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ2
5.26Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
5.26Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
5.26Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
5.26Single9K6LSA09K6L-TAS2R16-SA0-Gi2/β1/γ2
5.26Single9KPESA09KPE-TAS2R16-SA0-Gi1/β1/γ2
5.26Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
5.26Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
5.26Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Consensusalpha2_offOrthosteric Ligandalpha2c_off
5.26Consensusangiotensin_offOrthosteric Ligandat1_off
5.26Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
5.26Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
5.26Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
5.26Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
5.26Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
5.26Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
5.26Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
5.26Consensusorexin_offOrthosteric Ligandox2_off ox1_off
5.26Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
5.26Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
5.26Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
5.26Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
5.26Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
5.00Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
5.00Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
5.00Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
5.00Single4ZJCSB-6740424ZJC-OX1-SB-674042
5.00Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
5.00Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
5.00Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
5.00Single6PS0S-Carazolol6PS0-β2-S-Carazolol
5.00Single6PS4ICI118-5516PS4-β2-ICI118-551
5.00Single6PS5S-Propranolol6PS5-β2-S-Propranolol
5.00Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
5.00Single6TP3Nemorexant6TP3-OX1-Nemorexant
5.00Single6TPGEMPA6TPG-OX2-EMPA
5.00Single6TPKRetosiban6TPK-OT-Retosiban
5.00Single6V9SGTPL114036V9S-OX1-GTPL11403
5.00Single6VI4JDTic6VI4-κ-JDTic
5.00Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
5.00Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
5.00Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
5.00Single6ZG9GSK10347026ZG9-M1-GSK1034702
5.00Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
5.00Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
5.00Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
5.00Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
5.00Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
5.00Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
5.00Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
5.00Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
5.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
5.00Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.00Single7T94Acetylcholine7T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
5.00Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
5.00Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
5.00Single7VODCariprazine7VOD-5-HT2A-Cariprazine
5.00Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
5.00Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
5.00Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
5.00Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
5.00Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
5.00Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
5.00Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
5.00Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
5.00Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
5.00Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
5.00Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
5.00Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
5.00Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
5.00Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
5.00Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
5.00Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
5.00Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.00Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
5.00Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
5.00Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
5.00Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
5.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
5.00Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9ARXSerotonin9ARX-5-HT2A-Serotonin
5.00Single9AS5Mescaline9AS5-5-HT2A-Mescaline
5.00Single9AS6Mescaline9AS6-5-HT2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
5.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
5.00Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
5.00Single9KPDSA09KPD-TAS2R16-SA0-chim(Gs-CtGt3)/β1/γ2
5.00Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
5.00Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
5.00Consensusalpha1_onOrthosteric Ligandalpha1a_on
5.00Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
5.00Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
5.00Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
5.00Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
5.00Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
5.00Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
5.00Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
5.00Consensusopsins_offOrthosteric Ligandrhodopsin_off
5.00Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
5.00Consensussensory_offOrthosteric Ligandopsins_off
5.00Consensusvasop-oxy_offOrthosteric Ligandot_off
4.76Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
4.76Single2Y04Salbutamol2Y04-β1-Salbutamol
4.76Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
4.76Single3NY8ICI118-5513NY8-β2-ICI118-551
4.76Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
4.76Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
4.76Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
4.76Single4DAJTiotropium4DAJ-M3-Tiotropium
4.76Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
4.76Single4GBRS-Carazolol4GBR-β2-S-Carazolol
4.76Single4MQSIperoxo4MQS-M2-Iperoxo
4.76Single4QKX35V4QKX-β2-35V
4.76Single4U14Tiotropium4U14-M3-Tiotropium
4.76Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
4.76Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
4.76Single4YAYZD-71554YAY-AT1-ZD-7155
4.76Single5DHHSB-6121115DHH-NOP-SB-612111
4.76Single5DSGTiotropium5DSG-M4-Tiotropium
4.76Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
4.76Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
4.76Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
4.76Single6H7MSalbutamol6H7M-β1-Salbutamol
4.76Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
4.76Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
4.76Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
4.76Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
4.76Single6TOTLemborexant6TOT-OX1-Lemborexant
4.76Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
4.76Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
4.76Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
4.76Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
4.76Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
4.76Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
4.76Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
4.76Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
4.76Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
4.76Single7UL4Alvimopan7UL4-μ-Alvimopan
4.76Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
4.76Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
4.76Single7WC7Lisuride7WC7-5-HT2A-Lisuride
4.76Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
4.76Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
4.76Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
4.76Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
4.76Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
4.76Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
4.76Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
4.76Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
4.76Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
4.76Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
4.76Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
4.76Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
4.76Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
4.76Single8JJOAlprenolol8JJO-β2-Alprenolol
4.76Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
4.76Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
4.76Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
4.76Single8PJKST1718PJK-5-HT1A-ST171-Gi1/β1/γ1
4.76Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
4.76Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.76Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
4.76Single8X63Mepyramine8X63-H1-Mepyramine
4.76Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
4.76Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
4.76Single8YN8Proxyfan8YN8-H3-Proxyfan-Go/β1/γ2
4.76Single9AS1DMT9AS1-5-HT2A-DMT
4.76Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
4.76Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
4.76Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
4.76Single9IYAONO-97105319IYA-GPR55-ONO-9710531
4.76Single9JEAAtropine9JEA-M1-Atropine
4.76Single9PLNN-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLN-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine
4.76Single9PLON-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLO-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine-Go/β1/γ2
4.76Single9PQD(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole9PQD-α2a-(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole
4.76Consensus5ht5_onOrthosteric Ligand5ht5a_on
4.76Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
4.76Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
4.76Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
4.76Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
4.76Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
4.76Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
4.76Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
4.76Consensusalpha2_onOrthosteric Ligandalpha2b_on
4.76Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
4.76Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
4.76Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
4.76Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
4.76Consensusdopamine_offOrthosteric Ligandd2_off d3_off
4.76Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
4.76Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
4.76Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
4.76Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
4.76Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
4.76Consensushistamine_offOrthosteric Ligandh1_off
4.76Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
4.76Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
4.76Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
4.76Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
4.55Single2RH1S-Carazolol2RH1-β2-S-Carazolol
4.55Single2Y03Isoprenaline2Y03-β1-Isoprenaline
4.55Single2YCWS-Carazolol2YCW-β1-S-Carazolol
4.55Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
4.55Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
4.55Single5CGCHTL142425CGC-mGlu5-HTL14242
4.55Single5D6LS-Carazolol5D6L-β2-S-Carazolol
4.55Single5JQHS-Carazolol5JQH-β2-S-Carazolol
4.55Single5TVNLSD5TVN-5-HT2B-LSD
4.55Single5WQCEMPA5WQC-OX2-EMPA
4.55Single5XPRBosentan5XPR-ETB-Bosentan
4.55Single6HLPNetupitant6HLP-NK1-Netupitant
4.55Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
4.55Single6LUQHaloperidol6LUQ-D2-Haloperidol
4.55Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
4.55Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
4.55Single6PS6Timolol6PS6-β2-Timolol
4.55Single6TP6Filorexant6TP6-OX1-Filorexant
4.55Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
4.55Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.55Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
4.55Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
4.55Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
4.55Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
4.55Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
4.55Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
4.55Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
4.55Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
4.55Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
4.55Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.55Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
4.55Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
4.55Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.55Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.55Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
4.55Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
4.55Single8ZVZBW245C8ZVZ-DP1-BW245C-Gs/β1/γ2
4.55Single9ARYSerotonin9ARY-5-HT2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single9ARZ2-bromo-LSD9ARZ-5-HT2A-2-bromo-LSD
4.55Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
4.55Single9F33FOB02-04A9F33-D3-FOB02-04A-Go/β1/γ2
4.55Single9HC04YI9HC0-mGlu5-4YI
4.55Single9K07DSO-5a9K07-BB3-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55Single9KPFSA09KPF-TAS2R16-SA0-Gi1/β1/γ2
4.55Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
4.55Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
4.55Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
4.55Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
4.55Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
4.55Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
4.55Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
4.55Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
4.55Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
4.55Consensusamine_offonOrthosteric Ligandamine_off amine_on
4.55Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
4.55Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
4.55Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
4.55Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
4.55Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.55Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
4.55Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
4.55Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
4.55Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
4.55Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
4.55Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.55Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.35Single4DJHJDTic4DJH-κ-JDTic
4.35Single4U15Tiotropium4U15-M3-Tiotropium
4.35Single5D5AS-Carazolol5D5A-β2-S-Carazolol
4.35Single5D5BS-Carazolol5D5B-β2-S-Carazolol
4.35Single5V54Methiothepin5V54-5-HT1B-Methiothepin
4.35Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
4.35Single6H7JIsoprenaline6H7J-β1-Isoprenaline
4.35Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
4.35Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
4.35Single6OL9Tiotropium6OL9-M5-Tiotropium
4.35Single6TQ7SB-3348676TQ7-OX1-SB-334867
4.35Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
4.35Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
4.35Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
4.35Single7P2L4YI7P2L-mGlu5-4YI
4.35Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
4.35Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
4.35Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
4.35Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
4.35Single8EA0Iperoxo8EA0-M3-Iperoxo
4.35Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
4.35Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.35Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
4.35Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
4.35Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.35Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
4.35Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
4.35Single8XVLZibotentan8XVL-ETA-Zibotentan
4.35Single9I54A1IZV9I54-D1-A1IZV-Gs/β1/γ2
4.35Consensus5ht1_offOrthosteric Ligand5ht1b_off
4.35Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
4.35Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
4.35Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
4.35Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
4.35Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
4.35Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
4.35Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
4.35Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
4.35Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
4.35Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
4.35Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
4.35Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
4.35Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
4.35Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
4.17Single3D4STimolol3D4S-β2-Timolol
4.17Single5CXVTiotropium5CXV-M1-Tiotropium
4.17Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
4.17Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
4.17Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
4.17Single6ZG4HTL00099366ZG4-M1-HTL0009936
4.17Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
4.17Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
4.17Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
4.17Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.17Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
4.17Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
4.17Single8JD3JNJ-404118138JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
4.17Single9GL2Befiradol9GL2-5-HT1A-Befiradol-Gs/β1/γ2
4.17Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
4.17Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
4.17Consensusalpha1_offOrthosteric Ligandalpha1a_off
4.17Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
4.17Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
4.17Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
4.00Single5CGDHTL142425CGD-mGlu5-HTL14242
4.00Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
4.00Single5X93K-87945X93-ETB-K-8794
4.00Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
4.00Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
4.00Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
4.00Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
4.00Single8S2TIsoprenaline8S2T-β1-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
4.00Single8XVJMacitentan8XVJ-ETA-Macitentan
4.00Single9DYEBuspirone9DYE-5-HT1A-Buspirone-Go/β1/γ2
4.00Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
4.00Consensusendothelin_offOrthosteric Ligandetb_off
4.00Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
3.85Single9MD1Buspirone9MD1-5-HT1A-Buspirone-Gz/β1/γ2
3.85Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
3.85Consensuskisspeptin_onOrthosteric Ligandkiss1_on
3.70Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
3.70Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
3.70Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
3.70Single8PKMBefiradol8PKM-5-HT1A-Befiradol-Gi1/β1/γ1
3.70Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
3.70Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
3.70Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
3.70Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
3.70Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
3.70Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
3.57Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
3.45Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
3.45Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
3.33Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
3.33Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
3.03Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3

Consensus Members
Id Members
8IC0 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
Net Summary
Imin 2.85
Number of Linked Nodes 866
Number of Links 1028
Number of Hubs 154
Number of Links mediated by Hubs 581
Number of Communities 26
Number of Nodes involved in Communities 217
Number of Links involved in Communities 301
Path Summary
Number Of Nodes in MetaPath 114
Number Of Links MetaPath 113
Number of Shortest Paths 4393715
Length Of Smallest Path 3
Average Path Length 39.5108
Length of Longest Path 66
Minimum Path Strength 1.175
Average Path Strength 5.99211
Maximum Path Strength 21.36
Minimum Path Correlation 0.71
Average Path Correlation 0.994376
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.78571
Average % Of Corr. Nodes 37.1956
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 45.5181
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
cxcr_on_gpcxcr3_on_gp
cxcr4_on_gp
cxcr1_on_gp
cxcr2_on_gp



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Download cxcr1_on_gp.zip



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