Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:E16 8.2354184
2A:A:D33 5.385405
3A:A:H41 7.0825446
4A:A:L45 9.0525438
5A:A:K53 7.8225439
6A:A:V217 6.3575445
7A:A:F219 7.656508
8A:A:M221 5.41167638
9A:A:F222 8.8925417
10A:A:Q227 4.73419
11A:A:R228 7.4225409
12A:A:K233 7.122519
13A:A:W234 6.99667619
14A:A:F238 11.445409
15A:A:I244 6.244238
16A:A:V247 5.37437
17A:A:S251 5.6254209
18A:A:F273 7.242509
19A:A:W277 9.7325406
20A:A:W281 6.814515
21A:A:L296 6.1954206
22A:A:Y311 8.14156
23A:A:F315 10.06406
24A:A:R336 6.42405
25A:A:Y339 5.7625113
26A:A:R342 7.6654114
27A:A:F345 5.85508
28A:A:S349 4.7925407
29A:A:Y358 9.8354194
30A:A:Y360 7.961676198
31A:A:F363 9.78254115
32A:A:T364 8.2125439
33A:A:N371 11.0425439
34A:A:R373 6.3775445
35A:A:F376 7.658548
36A:A:I383 5.215448
37A:A:Q384 5.2554246
38A:A:R385 6.57754195
39A:A:H387 7.315448
40B:B:Q32 3.51401
41B:B:R48 4.9775467
42B:B:H54 11.1665109
43B:B:L55 11.3875406
44B:B:Y59 7.3125418
45B:B:W63 7.56607
46B:B:L69 5.354215
47B:B:Q75 10.04419
48B:B:D76 8.7625409
49B:B:I81 6.384217
50B:B:W82 11.33176109
51B:B:Y85 11.254564
52B:B:T86 8.35754186
53B:B:N88 8.7545187
54B:B:K89 8.0325109
55B:B:I93 6.035407
56B:B:L95 5.4285128
57B:B:W99 10.0467619
58B:B:Y105 5.298506
59B:B:N110 6.83754164
60B:B:Y111 6.943336164
61B:B:I123 5.3754166
62B:B:Y124 9.055126
63B:B:V135 7.22754124
64B:B:L139 6.6725409
65B:B:H142 10.1065139
66B:B:Y145 6.88143718
67B:B:R150 7.2875406
68B:B:F151 5.993336169
69B:B:L152 5.595403
70B:B:Q156 7.2775405
71B:B:D163 7.6865139
72B:B:W169 11.75836138
73B:B:Q176 9.33254134
74B:B:D186 7.294519
75B:B:M188 6.865418
76B:B:L190 6.3325455
77B:B:F199 7.036559
78B:B:K209 9.238556
79B:B:W211 11.782558
80B:B:E215 8.4554273
81B:B:C218 6.1875455
82B:B:F222 8.26478
83B:B:H225 9.13143779
84B:B:I232 6.6525408
85B:B:F234 3.825405
86B:B:F235 8.4585286
87B:B:F241 10.414576
88B:B:D247 8.018579
89B:B:T249 9.34476
90B:B:R251 12.3467678
91B:B:F253 7.454576
92B:B:Y264 7.68667605
93B:B:I269 6.69484
94B:B:F278 8.934287
95B:B:R283 6.611676269
96B:B:Y289 7.43787
97B:B:N293 7.415485
98B:B:N295 12.8625486
99B:B:V296 4.93405
100B:B:W297 12.2475488
101B:B:D298 5.745269
102B:B:K301 9.2575405
103B:B:R304 15485
104B:B:L308 10.8825407
105B:B:H311 11.035499
106B:B:R314 15.165418
107B:B:M325 7.885465
108B:B:W332 9.71143719
109B:B:D333 10.725499
110B:B:F335 6.958594
111B:B:K337 9.028596
112B:B:W339 9.39699
113B:B:N340 7.946569
114G:G:L19 4.3775459
115G:G:E22 7.11459
116G:G:L50 5.9325469
117L:L:?1 9.7781020
118R:R:L54 5.4075408
119R:R:N59 8.61409
120R:R:H63 6.60254296
121R:R:M65 5.95254149
122R:R:D69 7.0325149
123R:R:F70 4.0375407
124R:R:L72 5.44407
125R:R:V76 5.772527
126R:R:M77 7.374507
127R:R:Y79 9.3054175
128R:R:M81 5.365426
129R:R:W89 8.301437177
130R:R:F91 10.17254176
131R:R:H99 5.925405
132R:R:H113 6.915148
133R:R:R121 9.032509
134R:R:Y122 11.2825408
135R:R:L129 6.094547
136R:R:Y131 9.34447
137R:R:M135 5.4525447
138R:R:V150 4.35404
139R:R:F160 4.5665304
140R:R:F165 6.505424
141R:R:Y172 6.6025423
142R:R:F185 9.396521
143R:R:F186 7.405421
144R:R:F195 6.868525
145R:R:F199 8.992528
146R:R:Y210 5.132509
147R:R:Y214 4.2475405
148R:R:W264 7.60143728
149R:R:F267 7.97167625
150R:R:F268 8.648527
151R:R:I290 6.625425
152R:R:W291 9.31167624
153R:R:Y294 8.95833627
154R:R:N300 7.7485149
155R:R:Y304 7.56409
156R:R:F306 4.36406
157R:R:Y308 7.58408
158R:R:W310 9.02406
159R:R:F311 7.515609
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:H54 B:B:W82 97.79018.46YesYes1099
2B:B:H54 B:B:S74 98.00968.37YesNo099
3B:B:D76 B:B:S74 97.98695.89YesNo099
4B:B:D76 B:B:L55 87.454119YesYes096
5A:A:D33 B:B:L55 13.50925.43YesYes056
6B:B:D76 B:B:K78 36.39665.53YesNo098
7A:A:D33 B:B:K78 13.3724.15YesNo058
8A:A:Y37 B:B:L55 99.971214.07NoYes046
9A:A:D240 A:A:Y37 99.786.9NoNo164
10A:A:D240 B:B:Q75 99.758513.05NoYes169
11B:B:Q75 B:B:W99 79.24446.57YesYes199
12B:B:M61 B:B:W63 99.24243.49NoYes067
13B:B:G319 B:B:M61 99.27163.49NoNo056
14B:B:G319 B:B:S277 99.28613.71NoNo055
15B:B:S277 B:B:V320 99.31466.46NoNo057
16B:B:L286 B:B:V320 99.34264.47NoNo077
17B:B:L286 B:B:V327 97.03444.47NoNo076
18B:B:V327 B:B:W339 97.04483.68NoYes069
19B:B:K337 B:B:W339 99.43855.8YesYes969
20B:B:F335 B:B:K337 99.41673.72YesYes946
21B:B:F335 R:R:K52 99.77923.72YesNo946
22R:R:H55 R:R:K52 99.94811.79NoNo086
23R:R:H55 R:R:W60 99.95496.35NoNo084
24R:R:H63 R:R:W60 99.97496.35YesNo064
25R:R:H63 R:R:I48 1006.63YesNo067
26R:R:I48 R:R:N59 50.7897.08NoYes079
27R:R:N59 R:R:W310 48.85710.17YesYes096
28R:R:W310 R:R:Y308 97.549212.54YesYes068
29R:R:R121 R:R:Y308 96.558311.32YesYes098
30A:A:Y391 R:R:R121 53.032116.46NoYes049
31A:A:Y391 R:R:A124 51.82574NoNo048
32A:A:H387 R:R:A124 51.50315.85YesNo488
33A:A:H387 A:A:I383 51.83746.63YesYes488
34A:A:H41 A:A:I383 46.39665.3YesYes468
35A:A:F219 A:A:H41 45.85594.53YesYes086
36R:R:F311 R:R:I48 49.22763.77YesNo097
37R:R:F311 R:R:W310 48.92211.02YesYes096
38A:A:F219 A:A:L43 33.54239.74YesNo087
39A:A:L43 A:A:M221 17.08414.24NoYes378
40A:A:F212 A:A:F219 17.693511.79NoYes098
41A:A:F212 A:A:M221 17.0843.73NoYes398
42A:A:I245 A:A:L43 16.2647.14NoNo377
43A:A:F238 B:B:W99 77.992716.04YesYes099
44A:A:L45 A:A:M221 32.155411.31YesYes388
45A:A:I245 A:A:L45 16.06444.28NoYes378
46A:A:D223 A:A:L45 39.773613.57NoYes398
47A:A:D223 A:A:F208 39.32592.39NoNo095
48A:A:F208 A:A:S205 38.10442.64NoNo057
49A:A:G206 A:A:S205 37.49343.71NoNo087
50A:A:G206 B:B:N119 36.27126.79NoNo089
51R:R:R121 R:R:Y210 24.35867.2YesYes099
52R:R:S118 R:R:Y210 22.64146.36NoYes089
53R:R:S118 R:R:V209 10.58396.46NoNo087
54R:R:V209 R:R:Y122 10.48067.57NoYes078
55A:A:F238 A:A:W234 71.64065.01YesYes099
56A:A:W234 B:B:Y145 69.97816.75YesYes198
57A:A:K233 B:B:Y145 68.76733.58YesYes198
58A:A:K233 B:B:D228 34.332513.83YesNo099
59A:A:K233 B:B:N230 34.33364.2YesNo099
60B:B:K57 B:B:Q75 10.3318.14NoYes199
61B:B:K57 B:B:W332 10.216524.37NoYes199
62B:B:Q75 B:B:Y59 10.451512.4YesYes198
63B:B:W332 B:B:Y59 10.29823.86YesYes198
64B:B:R314 B:B:W332 18.391818.99YesYes189
65B:B:K78 B:B:P94 48.88515.02NoNo085
66B:B:I93 B:B:P94 48.71173.39YesNo075
67B:B:I93 B:B:V133 43.10149.22YesNo074
68B:B:H91 B:B:V133 42.92416.92NoNo054
69B:B:H91 B:B:I81 28.43419.28NoYes2157
70B:B:I81 B:B:L69 14.12634.28YesYes2175
71B:B:L69 B:B:Y105 27.49745.86YesYes056
72B:B:H62 B:B:Y105 39.54364.36NoYes066
73B:B:H62 B:B:R150 38.974415.8NoYes066
74B:B:L190 B:B:R150 36.6973.64YesYes056
75B:B:F199 B:B:L190 33.26429.74YesYes595
76B:B:F199 B:B:W211 31.55398.02YesYes598
77B:B:C218 B:B:W211 25.82779.14YesYes558
78B:B:C218 G:G:Q18 12.6364.58YesNo559
79G:G:L19 G:G:Q18 12.06295.32YesNo599
80B:B:L14 G:G:L19 21.8444.15NoYes089
81B:B:L14 G:G:V16 19.54672.98NoNo087
82B:B:E10 G:G:V16 17.24891.43NoNo087
83B:B:E10 B:B:Q6 16.09983.82NoNo081
84B:B:H91 B:B:V90 14.31258.3NoNo2155
85B:B:L69 B:B:V90 14.1264.47YesNo2155
86B:B:I81 B:B:L126 14.12644.28YesNo075
87B:B:L126 B:B:Y105 13.75314.69NoYes056
88B:B:C218 G:G:E22 12.63644.56YesYes559
89G:G:E22 G:G:L19 12.07796.63YesYes599
90B:B:D228 B:B:D246 34.36125.32NoNo099
91B:B:D246 B:B:S227 68.34185.89NoNo096
92B:B:D247 B:B:S227 68.10037.36YesNo096
93B:B:D247 B:B:H225 38.524910.08YesYes799
94B:B:H225 B:B:T243 23.91188.21YesNo098
95B:B:F253 B:B:T243 13.55367.78YesNo068
96B:B:F222 B:B:F253 33.67935.36YesYes786
97B:B:F222 B:B:Q220 31.61918.2YesNo087
98B:B:D258 B:B:Q220 18.984314.36NoNo077
99B:B:D258 B:B:R22 17.930616.68NoNo076
100B:B:D246 B:B:N230 34.222413.46NoNo099
101B:B:H225 B:B:R251 14.347118.05YesYes798
102B:B:F253 B:B:R251 40.11665.34YesYes768
103B:B:D247 B:B:E226 14.32295.2YesNo093
104B:B:E226 B:B:R251 14.06056.98NoYes038
105B:B:D247 B:B:T249 14.588611.56YesYes796
106B:B:R251 B:B:T249 14.062715.52YesYes786
107B:B:D290 B:B:R314 18.39521.44NoYes168
108B:B:D290 B:B:G272 18.17045.03NoNo064
109B:B:C271 B:B:G272 17.93223.92NoNo054
110B:B:C271 B:B:Y289 16.68824.03NoYes857
111B:B:W297 B:B:Y289 11.62739.65YesYes887
112B:B:W297 B:B:Y264 10.34249.65YesYes085
113B:B:L70 B:B:W82 96.61124.56NoYes059
114B:B:G144 B:B:N119 35.65993.39NoNo089
115B:B:D163 B:B:G144 35.04855.03YesNo098
116B:B:D163 B:B:H142 31.986410.08YesYes1399
117B:B:H142 B:B:W169 27.687711.64YesYes1398
118B:B:I157 B:B:W169 11.08213.52NoYes078
119B:B:F151 B:B:I157 10.467110.05YesNo097
120B:B:L139 B:B:W169 13.544315.94YesYes098
121B:B:I123 B:B:L139 10.47774.28YesYes069
122B:B:I232 B:B:T243 10.09994.56YesNo088
123B:B:A193 B:B:F234 22.21024.16NoYes045
124B:B:A193 B:B:D195 20.62454.63NoNo045
125B:B:D195 B:B:R197 19.03875.96NoNo055
126B:B:R197 B:B:R214 17.452812.79NoNo059
127B:B:R214 B:B:V213 15.86682.62NoNo094
128B:B:L152 B:B:V213 14.28075.96YesNo034
129B:B:F234 B:B:F241 21.1284.29YesYes056
130B:B:F241 B:B:F253 18.946411.79YesYes766
131B:B:L210 B:B:Q220 11.60613.99NoNo057
132R:R:M206 R:R:S118 28.09376.13NoNo098
133R:R:F260 R:R:M206 27.72886.22NoNo099
134R:R:F199 R:R:F260 27.28147.5YesNo089
135R:R:F199 R:R:F268 18.902720.36YesYes287
136L:L:?1 R:R:F268 15.94744.14YesYes207
137R:R:I117 R:R:R121 27.82295.01NoYes099
138R:R:I117 R:R:Y304 27.84436.04NoYes099
139R:R:M65 R:R:Y304 21.97135.99YesYes099
140R:R:D69 R:R:M65 15.89944.16YesYes1499
141R:R:D69 R:R:S297 14.24237.36YesNo099
142R:R:L72 R:R:S297 14.07237.51YesNo079
143B:B:L70 B:B:W63 96.630712.53NoYes057
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:R83 9.08 2 Yes No 0 4 0 1
L:L:?1 R:R:T100 6.01 2 Yes No 0 4 0 1
L:L:?1 R:R:D103 15.68 2 Yes No 0 6 0 1
L:L:?1 R:R:I104 7.76 2 Yes No 0 4 0 1
L:L:?1 R:R:S107 10.21 2 Yes No 0 6 0 1
L:L:?1 R:R:V184 9.11 2 Yes No 0 4 0 1
L:L:?1 R:R:F186 6.62 2 Yes Yes 0 1 0 1
L:L:?1 R:R:F267 16.56 2 Yes Yes 0 5 0 1
L:L:?1 R:R:F268 4.14 2 Yes Yes 0 7 0 1
L:L:?1 R:R:I290 12.61 2 Yes Yes 0 5 0 1
R:R:D103 R:R:V76 11.69 2 No Yes 6 7 1 2
R:R:V76 R:R:Y294 3.79 2 Yes Yes 7 7 2 2
R:R:R83 R:R:S80 9.22 0 No No 4 6 1 2
R:R:S80 R:R:Y294 7.63 0 No Yes 6 7 2 2
R:R:R83 R:R:W89 6 0 No Yes 4 7 1 2
R:R:D103 R:R:Y294 10.34 2 No Yes 6 7 1 2
R:R:S107 R:R:W264 4.94 0 No Yes 6 8 1 2
R:R:N164 R:R:V184 4.43 2 No No 4 4 2 1
R:R:F186 R:R:N164 7.25 2 Yes No 1 4 1 2
R:R:F186 R:R:V184 13.11 2 Yes No 1 4 1 1
R:R:F195 R:R:F199 7.5 2 Yes Yes 5 8 2 2
R:R:F195 R:R:F268 5.36 2 Yes Yes 5 7 2 1
R:R:F199 R:R:W264 4.01 2 Yes Yes 8 8 2 2
R:R:F199 R:R:F268 20.36 2 Yes Yes 8 7 2 1
R:R:F267 R:R:W264 7.02 2 Yes Yes 5 8 1 2
R:R:F268 R:R:W264 8.02 2 Yes Yes 7 8 1 2
R:R:F267 R:R:F268 5.36 2 Yes Yes 5 7 1 1
R:R:F267 R:R:T271 7.78 2 Yes No 5 5 1 2
R:R:F267 R:R:L289 6.09 2 Yes No 5 5 1 2
R:R:F267 R:R:I290 5.02 2 Yes Yes 5 5 1 1
R:R:I290 R:R:Y294 6.04 2 Yes Yes 5 7 1 2
R:R:A155 R:R:I104 3.25 0 No No 6 4 2 1
R:R:I290 R:R:N286 2.83 2 Yes No 5 4 1 2
R:R:F186 R:R:S190 2.64 2 Yes No 1 6 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
69.23Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
66.67Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
66.67Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
64.29Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
64.29Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
64.29Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
63.64Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
63.64Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
62.50Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
61.54Single2Y04Salbutamol2Y04-β1-Salbutamol
61.54Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
61.54Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
61.54Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
61.54Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
61.54Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
61.54Single9CHXS-Carazolol9CHX-β2-S-Carazolol
60.00Single9CHUNoradrenaline9CHU-β2-Noradrenaline
58.82Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
58.33Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
58.33Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
58.33Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
58.33Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
58.33Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
58.33Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
58.33Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
58.33Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
58.33Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
58.33Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
58.33Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
58.33Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
58.33Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
58.33Consensusalpha2_offOrthosteric Ligandalpha2c_off
57.14Single2Y03Isoprenaline2Y03-β1-Isoprenaline
57.14Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
57.14Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
57.14Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
57.14Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
57.14Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
57.14Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
57.14Consensustrace-amine_onOrthosteric Ligandta1_on
54.55Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
54.55Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
54.55Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
53.85Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
53.85Single6PS0S-Carazolol6PS0-β2-S-Carazolol
53.85Single6PS4ICI118-5516PS4-β2-ICI118-551
53.85Single6PS5S-Propranolol6PS5-β2-S-Propranolol
53.85Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
53.85Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
53.85Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
53.85Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
53.85Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
53.85Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
53.85Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
53.85Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
53.85Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
53.85Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
53.85Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
53.85Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
53.85Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
53.85Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
53.85Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
53.85Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
53.85Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
53.85Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
53.85Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
53.85Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
53.85Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
53.85Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
53.85Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
53.85Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
53.33Single2YDVNECA2YDV-A2A-NECA
53.33Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
53.33Single4UHRCGS216804UHR-A2A-CGS21680
53.33Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
53.33Single5G53NECA5G53-A2A-NECA-Gs
53.33Single6H7JIsoprenaline6H7J-β1-Isoprenaline
53.33Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
53.33Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
53.33Single7B6WCyclazosin7B6W-α1b-Cyclazosin
53.33Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
53.33Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
53.33Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
53.33Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
53.33Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
53.33Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
53.33Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
53.33Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
53.33Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
53.33Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
50.00Single3NY8ICI118-5513NY8-β2-ICI118-551
50.00Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
50.00Single3OE9IT1t3OE9-CXCR4-IT1t
50.00Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
50.00Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
50.00Single4GBRS-Carazolol4GBR-β2-S-Carazolol
50.00Single4LDEBI1671074LDE-β2-BI167107
50.00Single4QKX35V4QKX-β2-35V
50.00Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
50.00Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
50.00Single6DRXLisuride6DRX-5-HT2B-Lisuride
50.00Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
50.00Single6H7MSalbutamol6H7M-β1-Salbutamol
50.00Single6PS1Timolol6PS1-β2-Timolol
50.00Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
50.00Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
50.00Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
50.00Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
50.00Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
50.00Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
50.00Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
50.00Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
50.00Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
50.00Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
50.00Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
50.00Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
50.00Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
50.00Single7WC7Lisuride7WC7-5-HT2A-Lisuride
50.00Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
50.00Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
50.00Single8CU6LJ-45178CU6-A2A-LJ-4517
50.00Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
50.00Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
50.00Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
50.00Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
50.00Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
50.00Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
50.00Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
50.00Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
50.00Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
50.00Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
50.00Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
50.00Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
50.00Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
50.00Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
50.00Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
50.00Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
50.00Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
50.00Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
50.00Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
50.00Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
50.00Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
50.00Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
50.00Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
50.00Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
50.00Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
50.00Single8JJLOlodaterol8JJL-β2-Olodaterol
50.00Single8JJOAlprenolol8JJO-β2-Alprenolol
50.00Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
50.00Single8JWY2-1188JWY-A2A-2-118
50.00Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
50.00Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
50.00Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
50.00Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
50.00Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
50.00Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
50.00Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
50.00Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
50.00Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
50.00Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
50.00Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
50.00Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
50.00Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
50.00Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
50.00Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
50.00Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
50.00Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
50.00Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
50.00Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
50.00Consensus5ht5_onOrthosteric Ligand5ht5a_on
50.00Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
50.00Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
50.00Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
50.00Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
50.00Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
50.00Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
50.00Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
50.00Consensusdopamine_offOrthosteric Ligandd2_off d3_off
50.00Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
50.00Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
50.00Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
50.00Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
50.00Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
50.00Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
50.00Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
50.00Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
50.00Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
47.37Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
47.06Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
47.06Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
47.06Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
47.06Single6H7LDobutamine6H7L-β1-Dobutamine
47.06Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
47.06Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
47.06Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
47.06Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
47.06Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
47.06Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
47.06Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
47.06Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
47.06Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
47.06Consensusendothelin_offOrthosteric Ligandetb_off
47.06Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
46.67Single2RH1S-Carazolol2RH1-β2-S-Carazolol
46.67Single2Y00Dobutamine2Y00-β1-Dobutamine
46.67Single2YCWS-Carazolol2YCW-β1-S-Carazolol
46.67Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
46.67Single5D6LS-Carazolol5D6L-β2-S-Carazolol
46.67Single5JQHS-Carazolol5JQH-β2-S-Carazolol
46.67Single5TVNLSD5TVN-5-HT2B-LSD
46.67Single5WIUNemonapride5WIU-D4-Nemonapride
46.67Single5WIVNemonapride5WIV-D4-Nemonapride-Na
46.67Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
46.67Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
46.67Single6D26Fevipiprant6D26-DP2-Fevipiprant
46.67Single6E67BI1671076E67-β2-BI167107-Gs (fused)
46.67Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
46.67Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
46.67Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
46.67Single6PS6Timolol6PS6-β2-Timolol
46.67Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
46.67Single7C61Ergotamine7C61-5-HT1B-Ergotamine
46.67Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
46.67Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
46.67Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
46.67Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
46.67Single7W41PD1762527W41-BB2-PD176252
46.67Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
46.67Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
46.67Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
46.67Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
46.67Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
46.67Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
46.67Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
46.67Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
46.67Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
46.67Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
46.67Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
46.67Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
46.67Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
46.67Single8JXSPF-61428JXS-D1-PF-6142
46.67Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
46.67Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
46.67Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
46.67Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
46.67Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
46.67Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
46.67Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
46.67Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
46.67Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
46.67Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
46.67Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
46.67Consensusamine_offonOrthosteric Ligandamine_off amine_on
46.67Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
46.67Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
46.67Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
46.67Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
46.67Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
46.67Consensusbombesin_offOrthosteric Ligandbb2_off
46.67Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
46.67Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
46.67Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
46.67Consensusdp_offOrthosteric Liganddp2_off
46.67Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
46.15Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
46.15Single6ME2Ramelteon6ME2-MT1-Ramelteon
46.15Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
46.15Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
46.15Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
46.15Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
46.15Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
46.15Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
46.15Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
46.15Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
46.15Single8IWESpermidine8IWE-TA9-Spermidine
46.15Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
46.15Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
46.15Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
46.15Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
46.15Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
46.15Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
46.15Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
46.15Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
46.15Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
46.15Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
46.15Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
46.15Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
45.45Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
45.45Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
45.45Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
45.45Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
45.00Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
45.00Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
45.00Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
44.44Single3NY9ICI118-5513NY9-β2-ICI118-551
44.44Single4UG2CGS216804UG2-A2A-CGS21680
44.44Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
44.44Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
44.44Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
44.44Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
43.75Single3P0GBI1671073P0G-β2-BI167107
43.75Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
43.75Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
43.75Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
43.75Single5D5AS-Carazolol5D5A-β2-S-Carazolol
43.75Single5D5BS-Carazolol5D5B-β2-S-Carazolol
43.75Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
43.75Single6J20Aprepitant6J20-NK1-Aprepitant
43.75Single6J21Aprepitant6J21-NK1-Aprepitant
43.75Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
43.75Single6TQ7SB-3348676TQ7-OX1-SB-334867
43.75Single6WGTLSD6WGT-5-HT2A-LSD
43.75Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
43.75Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
43.75Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
43.75Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
43.75Single7TUYGSK682753A7TUY-GPR183-GSK682753A
43.75Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
43.75Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
43.75Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
43.75Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
43.75Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
43.75Single8E0GBU728E0G-μ-BU72
43.75Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
43.75Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
43.75Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
43.75Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
43.75Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
43.75Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
43.75Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
43.75Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
43.75Single8XVLZibotentan8XVL-ETA-Zibotentan
43.75Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
43.75Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
43.75Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
43.75Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
43.75Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
43.75Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
43.75Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
43.75Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
43.75Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
42.86Single2YDOAdenosine2YDO-A2A-Adenosine
42.86Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
42.86Single6A94Zotepine6A94-5-HT2A-Zotepine
42.86Single6IQLL7458706IQL-D4-L745870
42.86Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
42.86Single6KUXRS-799486KUX-α2a-RS-79948
42.86Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
42.86Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
42.86Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
42.86Single6TPGEMPA6TPG-OX2-EMPA
42.86Single6TPNHTL66416TPN-OX2-HTL6641
42.86Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
42.86Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
42.86Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
42.86Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
42.86Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
42.86Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
42.86Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
42.86Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
42.86Single7T32ZM-2413857T32-A2A-ZM-241385
42.86Single7UL3Famotidine7UL3-H2-Famotidine
42.86Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
42.86Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
42.86Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
42.86Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
42.86Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
42.86Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
42.86Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
42.86Single8IHKAcifran8IHK-HCA3-Acifran
42.86Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
42.86Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
42.86Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
42.86Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
42.86Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
42.86Single8K5CAcipimox8K5C-HCA2-Acipimox
42.86Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
42.86Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
42.86Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
42.86Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
42.86Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
42.86Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
42.86Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
42.86Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
42.86Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
42.86Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
42.86Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
42.86Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
42.86Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
42.86Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
42.86Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
42.86Consensusalpha1_onOrthosteric Ligandalpha1a_on
42.86Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
42.86Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
42.86Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
42.86Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
42.86Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
42.86Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
42.86Consensushca_onOrthosteric Ligandhca2_on
42.86Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
42.86Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
42.11Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
42.11Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
42.11Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
42.11Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
42.11Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
42.11Single8WDTphotoNECA8WDT-A2A-photoNECA
42.11Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
42.11Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
42.11Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
41.67Single3OE6IT1t3OE6-CXCR4-IT1t
41.67Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
41.67Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
41.67Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
41.67Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
41.67Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
41.67Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
41.67Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
41.67Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
41.67Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
41.67Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
41.67Consensus5ht2_onOrthosteric Ligand5ht2b_on
41.67Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
41.67Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
41.67Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
41.67Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
41.18Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
41.18Single3D4STimolol3D4S-β2-Timolol
41.18Single4AMIBucindolol4AMI-β1-Bucindolol
41.18Single4RWADIPP-NH24RWA-δ-DIPP-NH2
41.18Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
41.18Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
41.18Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
41.18Single6MXTSalmeterol6MXT-β2-Salmeterol
41.18Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
41.18Single6ZG4HTL00099366ZG4-M1-HTL0009936
41.18Single7DFPSpiperone7DFP-D2-Spiperone
41.18Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
41.18Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
41.18Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
41.18Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
41.18Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
41.18Single7YITNalfurafine7YIT-κ-Nalfurafine
41.18Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
41.18Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
41.18Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
41.18Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
41.18Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
41.18Single8JJ8Formoterol8JJ8-β2-Formoterol
41.18Single8JWZAB9288JWZ-A2A-AB928-Na
41.18Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
41.18Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
41.18Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
41.18Consensusalpha1_offOrthosteric Ligandalpha1a_off
41.18Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
41.18Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
41.18Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
41.18Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
41.18Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
41.18Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
41.18Consensusorexin_onOrthosteric Ligandox2_on
41.18Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
41.18Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
40.91Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
40.91Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
40.00Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
40.00Single2Y01Dobutamine2Y01-β1-Dobutamine
40.00Single2Y02Carmoterol2Y02-β1-Carmoterol
40.00Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
40.00Single3QAKUK-4320973QAK-A2A-UK-432097
40.00Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
40.00Single4DAJTiotropium4DAJ-M3-Tiotropium
40.00Single4MQSIperoxo4MQS-M2-Iperoxo
40.00Single4U14Tiotropium4U14-M3-Tiotropium
40.00Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
40.00Single5DHGC-355DHG-NOP-C-35
40.00Single5DHHSB-6121115DHH-NOP-SB-612111
40.00Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
40.00Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
40.00Single5UIGCmpd-15UIG-A2A-Cmpd-1
40.00Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
40.00Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
40.00Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
40.00Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
40.00Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
40.00Single6TOTLemborexant6TOT-OX1-Lemborexant
40.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
40.00Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
40.00Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
40.00Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
40.00Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
40.00Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
40.00Single7UL4Alvimopan7UL4-μ-Alvimopan
40.00Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
40.00Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
40.00Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
40.00Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
40.00Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
40.00Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
40.00Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
40.00Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
40.00Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
40.00Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
40.00Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
40.00Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
40.00Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
40.00Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
40.00Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
40.00Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
40.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
40.00Single8JXRLSD8JXR-D1-LSD
40.00Single8K5DGSK2560738K5D-HCA2-GSK256073
40.00Single8T1WCVN4248T1W-GPR6-CVN424
40.00Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
40.00Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
40.00Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
40.00Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
40.00Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
40.00Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
40.00Single8X63Mepyramine8X63-H1-Mepyramine
40.00Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
40.00Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
40.00Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
40.00Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
40.00Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
40.00Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
40.00Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
40.00Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
40.00Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
40.00Consensusa3_onOrthosteric Liganda3a_on
40.00Consensusalpha2_onOrthosteric Ligandalpha2b_on
40.00Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
40.00Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
40.00Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
40.00Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
40.00Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
40.00Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
40.00Consensusbombesin_onOrthosteric Ligandbb2_on
40.00Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
40.00Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
40.00Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
40.00Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
40.00Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
40.00Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
40.00Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
40.00Consensushca_on_gpOrthosteric Ligandhca2_on_gp
40.00Consensushistamine_offOrthosteric Ligandh1_off
40.00Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
39.13Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
39.13Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
38.89Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
38.89Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
38.89Single5X93K-87945X93-ETB-K-8794
38.89Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
38.89Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
38.89Single6IBLArformoterol6IBL-β1-Arformoterol
38.89Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
38.89Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
38.89Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
38.89Single7EZCUKA7EZC-A2A-UKA
38.89Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
38.89Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
38.89Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
38.89Single7UM4AS26747237UM4-5-HT5A-AS2674723
38.89Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
38.89Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
38.89Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
38.89Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
38.89Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
38.89Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
38.89Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
38.89Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
38.89Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
38.89Consensuscck_onOrthosteric Ligandccka_on cckb_on
38.89Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
38.89Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
38.89Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
38.89Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
38.89Consensusprostanoid_offOrthosteric Ligandep_off dp_off
38.46Single3PBLEticlopride3PBL-D3-Eticlopride
38.46Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
38.46Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
38.46Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
38.46Single7SRQLSD7SRQ-5-HT2B-LSD
38.46Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
38.46Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
38.46Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
38.46Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
38.46Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
38.46Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
38.46Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
38.46Single8K5BNiacin8K5B-HCA2-Niacin
38.46Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
38.46Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
38.46Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
38.46Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
38.46Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
38.46Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
38.46Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
38.46Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
38.46Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
38.46Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
38.46Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
38.46Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
38.46Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
38.46Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
38.10Single5WF5UK-4320975WF5-A2A-UK-432097
38.10Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
38.10Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
38.10Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
38.10Consensusangiotensin_onOrthosteric Ligandat1_on
38.10Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
38.10Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
37.50Single5C1MBU725C1M-μ-BU72
37.50Single5N2SPSB365N2S-A1-PSB36
37.50Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
37.50Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
37.50Single5WQCEMPA5WQC-OX2-EMPA
37.50Single5XPRBosentan5XPR-ETB-Bosentan
37.50Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
37.50Single6LUQHaloperidol6LUQ-D2-Haloperidol
37.50Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
37.50Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
37.50Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
37.50Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
37.50Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
37.50Single7WC6LSD7WC6-5-HT2A-LSD
37.50Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
37.50Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
37.50Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
37.50Single8GNEKW-63568GNE-A2A-KW-6356-Na
37.50Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
37.50Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
37.50Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
37.50Single8ZMFA1L108ZMF-5-HT2C-A1L10
37.50Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
37.50Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
37.50Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
37.50Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
37.50Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
37.50Consensusa3_on_gpOrthosteric Liganda3a_on_gp
37.50Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
37.50Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
37.50Consensusadenosine_offOrthosteric Liganda1_off a2_off
37.50Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
37.50Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
37.50Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
37.50Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
37.50Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
37.50Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
37.50Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
37.50Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
37.50Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
37.50Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
37.50Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
36.84Single5ZTYAM102575ZTY-CB2-AM10257
36.84Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
36.84Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
36.84Single8QJ2pN1628QJ2-MC4-pN162-Gs
36.84Single8X5YAstemizole8X5Y-H1-Astemizole
36.84Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
36.84Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
36.84Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
36.84Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
36.84Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
36.36Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
36.36Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
36.36Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
36.36Single8PWNTheophylline8PWN-A2A-Theophylline
36.36Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
36.36Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
36.36Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
36.36Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
36.36Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
36.36Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
36.36Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
35.71Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
35.71Single3ODUIT1t3ODU-CXCR4-IT1t
35.71Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
35.71Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
35.71Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
35.71Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
35.71Single6AKXA4R6AKX-CCR5-A4R
35.71Single6AKYMaraviroc6AKY-CCR5-Maraviroc
35.71Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
35.71Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
35.71Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
35.71Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
35.71Single6TODEMPA6TOD-OX1-EMPA-Na
35.71Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
35.71Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
35.71Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
35.71Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
35.71Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
35.71Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.71Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
35.71Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
35.71Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
35.71Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
35.71Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
35.71Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
35.71Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
35.71Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
35.71Single7XRRLemborexant7XRR-OX2-Lemborexant
35.71Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
35.71Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
35.71Single8GNGIstradefylline8GNG-A2A-Istradefylline
35.71Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
35.71Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
35.71Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
35.71Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
35.71Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
35.71Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
35.71Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
35.71Single8Y0HVUF114188Y0H-CXCR3-VUF11418
35.71Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
35.71Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
35.71Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
35.71Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
35.71Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
35.71Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.71Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
35.71Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
35.71Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
35.71Consensusorexin_offOrthosteric Ligandox2_off ox1_off
35.71Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
35.71Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
35.71Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
35.71Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
35.29Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
35.29Single4U15Tiotropium4U15-M3-Tiotropium
35.29Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
35.29Single5V54Methiothepin5V54-5-HT1B-Methiothepin
35.29Single5XR8AM8415XR8-CB1-AM841
35.29Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
35.29Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
35.29Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
35.29Single6E59L-7607356E59-NK1-L-760735
35.29Single6OL9Tiotropium6OL9-M5-Tiotropium
35.29Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
35.29Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
35.29Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
35.29Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
35.29Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
35.29Single8EA0Iperoxo8EA0-M3-Iperoxo
35.29Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
35.29Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
35.29Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
35.29Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
35.29Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
35.29Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
35.29Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
35.29Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
35.29Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
35.29Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
35.29Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
35.29Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
35.29Consensus5ht1_offOrthosteric Ligand5ht1b_off
35.29Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
35.29Consensusa2_onOrthosteric Liganda2b_on
35.29Consensusa2_on_gpOrthosteric Liganda2b_on_gp
35.29Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
35.29Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
35.29Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
35.29Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
35.29Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
35.29Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
35.29Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
35.29Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
35.29Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
35.29Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
35.00Single4IARErgotamine4IAR-5-HT1B-Ergotamine
35.00Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
35.00Single4XT1Fractalkine4XT1-US28-Fractalkine
35.00Single7F8XNN90567F8X-CCKA-NN9056
35.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
35.00Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
35.00Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
35.00Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
35.00Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
35.00Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
35.00Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
35.00Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
35.00Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
35.00Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
35.00Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
34.78Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
34.78Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
34.78Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
34.62Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
33.33Single3OE8IT1t3OE8-CXCR4-IT1t
33.33Single3RZECidoxepin3RZE-H1-Cidoxepin
33.33Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
33.33Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
33.33Single4MBSMaraviroc4MBS-CCR5-Maraviroc
33.33Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
33.33Single4ZJCSB-6740424ZJC-OX1-SB-674042
33.33Single5CXVTiotropium5CXV-M1-Tiotropium
33.33Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
33.33Single5IU7Q274563465IU7-A2A-Q27456346-Na
33.33Single5IUBQ274563445IUB-A2A-Q27456344-Na
33.33Single5JTBZM-2413855JTB-A2A-ZM-241385
33.33Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
33.33Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
33.33Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
33.33Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
33.33Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
33.33Single6A93Risperidone6A93-5-HT2A-Risperidone
33.33Single6AQFZM-2413856AQF-A2A-ZM-241385
33.33Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
33.33Single6CM4Risperidone6CM4-D2-Risperidone
33.33Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
33.33Single6HLOAprepitant6HLO-NK1-Aprepitant
33.33Single6V9SGTPL114036V9S-OX1-GTPL11403
33.33Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
33.33Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
33.33Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
33.33Single6ZG9GSK10347026ZG9-M1-GSK1034702
33.33Single7AROLUF58337ARO-A2A-LUF5833-Na
33.33Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
33.33Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
33.33Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
33.33Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
33.33Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
33.33Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
33.33Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
33.33Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
33.33Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
33.33Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
33.33Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
33.33Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
33.33Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
33.33Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
33.33Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
33.33Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
33.33Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
33.33Single8A2OTheophylline8A2O-A2A-Theophylline-Na
33.33Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
33.33Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
33.33Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
33.33Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
33.33Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
33.33Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
33.33Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
33.33Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
33.33Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
33.33Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
33.33Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
33.33Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
33.33Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
33.33Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
33.33Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
33.33Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
33.33Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
33.33Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
33.33Single8XYIVUF106618XYI-CXCR3-VUF10661
33.33Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
33.33Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
33.33Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
33.33Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
33.33Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusa2_offOrthosteric Liganda2a_off
33.33Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
33.33Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
33.33Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
33.33Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
33.33Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
33.33Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
33.33Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
33.33Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
33.33Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
33.33Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
33.33Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
33.33Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
33.33Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
33.33Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
33.33Consensuslpa_offOrthosteric Ligandlpa1_off
33.33Consensuslpl_offOrthosteric Ligands1p_off lpa_off
33.33Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
33.33Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
33.33Consensusopsins_offOrthosteric Ligandrhodopsin_off
33.33Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
33.33Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
33.33Consensussensory_offOrthosteric Ligandopsins_off
33.33Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
33.33Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
32.00Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
32.00Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
32.00Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
32.00Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
31.82Single6PT2KGCHM076PT2-δ-KGCHM07
31.82Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
31.82Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
31.82Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
31.82Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
31.82Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
31.82Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
31.82Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
31.82Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
31.58Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
31.58Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
31.58Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
31.58Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
31.58Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
31.58Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
31.58Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.58Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
31.58Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.58Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
31.58Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.58Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
31.58Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
31.58Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
31.58Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
31.58Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
31.58Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
31.58Consensuschemerin_onOrthosteric Ligandcml1_on
31.58Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
31.58Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
31.25Single3EMLZM-2413853EML-A2A-ZM-241385
31.25Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
31.25Single4EJ4Naltrindole4EJ4-δ-Naltrindole
31.25Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
31.25Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
31.25Single4YAYZD-71554YAY-AT1-ZD-7155
31.25Single5DSGTiotropium5DSG-M4-Tiotropium
31.25Single5IU8Q274563475IU8-A2A-Q27456347-Na
31.25Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
31.25Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
31.25Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
31.25Single5TGZAM65385TGZ-CB1-AM6538
31.25Single5UENDU1725UEN-A1-DU172
31.25Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
31.25Single6D27CAY104716D27-DP2-CAY10471
31.25Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
31.25Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
31.25Single6S0LZM-2413856S0L-A2A-ZM-241385
31.25Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.25Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
31.25Single7BU7BI1671077BU7-β1-BI167107
31.25Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
31.25Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
31.25Single7PYRPSB-21157PYR-A2A-PSB-2115
31.25Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
31.25Single7V3ZCP559407V3Z-CB1-CP55940
31.25Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
31.25Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
31.25Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
31.25Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
31.25Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
31.25Single8RLNLUF58348RLN-A2A-LUF5834
31.25Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
31.25Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
31.25Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
31.25Single8X64Desloratadine8X64-H1-Desloratadine
31.25Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
31.25Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
31.25Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
31.25Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
31.25Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
31.25Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
31.25Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
31.25Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
31.25Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
31.25Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
30.77Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
30.77Single3UZAGTPL92363UZA-A2A-GTPL9236
30.77Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
30.77Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
30.77Single6IGLIRL16206IGL-ETB-IRL1620
30.77Single6ME5Agomelatine6ME5-MT1-Agomelatine
30.77Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
30.77Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
30.77Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
30.77Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
30.77Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
30.43Single6JODAngiotensin II6JOD-AT2-Angiotensin II
30.43Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
30.43Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
30.43Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
30.43Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
30.43Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
30.43Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
30.43Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
30.00Single5EE7MK08935EE7-Glucagon-MK0893
30.00Single5WF6UK-4320975WF6-A2A-UK-432097
30.00Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
30.00Single6PT3DPI-2876PT3-δ-DPI-287
30.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
30.00Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
30.00Single7SK9CCX6627SK9-ACKR3-CCX662
30.00Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
30.00Single7XN9L-054,5227XN9-SST2-L-054,522
30.00Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
30.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
30.00Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
30.00Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
30.00Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
30.00Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
30.00Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
30.00Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
29.63Single6IGKEndothelin-36IGK-ETB-Endothelin-3
29.63Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
29.41Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
29.41Single5IUAQ274563485IUA-A2A-Q27456348-Na
29.41Single5N2RPSB-365N2R-A2A-PSB-36-Na
29.41Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
29.41Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
29.41Single6S0QZM-2413856S0Q-A2A-ZM-241385
29.41Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
29.41Single6TP6Filorexant6TP6-OX1-Filorexant
29.41Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
29.41Single7C4SS1P7C4S-S1P3-S1P
29.41Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
29.41Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
29.41Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
29.41Single7SINNPS-21437SIN-CaS-NPS-2143
29.41Single7SINNPS-21437SIN-CaS-NPS-2143
29.41Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
29.41Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
29.41Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
29.41Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
29.41Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
29.41Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
29.41Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
29.41Single8QOTNanobody-E8QOT-μ-Nanobody-E
29.41Single8S4DCMF-0198S4D-Apelin-CMF-019
29.41Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
29.41Single8TF5Oleic acid8TF5-GPR6-Oleic acid
29.41Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
29.41Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
29.41Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
29.41Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
29.41Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
29.41Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
29.41Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
29.41Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
29.41Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
29.41Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
29.41Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
29.41Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
29.41Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
29.41Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
29.41Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
29.41Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
29.41Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
29.17Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
29.17Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
29.17Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
29.17Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
29.17Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
29.17Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17Single8ZRTET-18ZRT-ETB-ET-1
29.17Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
29.17Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
29.17Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
29.17Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
28.57Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
28.57Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
28.57Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
28.57Single6HLLCP999946HLL-NK1-CP99994
28.57Single6TP4ACT-4622066TP4-OX1-ACT-462206
28.57Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
28.57Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
28.57Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
28.57Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
28.57Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
28.57Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
28.57Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
28.57Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
28.57Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
28.57Single8IEBA1LYA8IEB-GPR156-A1LYA
28.57Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
28.57Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
28.57Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
28.57Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
28.57Single9B9Y7DY9B9Y-CB1-7DY
28.57Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
28.57Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
28.57Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
28.57Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
28.57Consensusgq_nucleotideOrthosteric Ligandgq_p2y
28.57Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
28.57Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
28.57Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
28.57Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
28.57Consensuslpl_onOrthosteric Ligands1p_on lpa_on
28.57Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
28.57Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
28.00Single4XT3Fractalkine4XT3-US28-Fractalkine
28.00Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
28.00Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
28.00Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
28.00Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
27.78Single4DJHJDTic4DJH-κ-JDTic
27.78Single5XRAAM115425XRA-CB1-AM11542
27.78Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
27.78Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
27.78Single7PX4PSB-21137PX4-A2A-PSB-2113
27.78Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
27.78Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
27.78Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
27.78Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
27.78Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
27.78Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
27.78Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
27.78Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
27.78Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
27.78Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
27.78Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
27.78Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
27.78Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
27.78Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
27.78Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
27.78Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
27.78Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
27.78Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
27.78Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
27.78Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
27.78Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
27.78Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
27.78Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
27.78Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
27.78Consensusrelaxin_onOrthosteric Ligandrxfp4_on
27.78Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
27.78Consensustachykinin_offOrthosteric Ligandnk1_off
27.59Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
27.27Single5MZPCaffeine5MZP-A2A-Caffeine-Na
27.27Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
27.27Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
27.27Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
27.27Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
27.27Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
27.27Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
27.27Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
27.27Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
27.27Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
27.27Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
27.27Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
27.27Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
27.27Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
27.27Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
26.92Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
26.92Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
26.92Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
26.92Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
26.92Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
26.92Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
26.92Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
26.92Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
26.67Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
26.67Single3PWHZM-2413853PWH-A2A-ZM-241385
26.67Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
26.67Single4S0VSuvorexant4S0V-OX2-Suvorexant
26.67Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
26.67Single5WS3EMPA5WS3-OX2-EMPA
26.67Single6B73MP11046B73-κ-MP1104
26.67Single6DS0Ly2660976DS0-5-HT2B-Ly266097
26.67Single6ME9Ramelteon6ME9-MT2-Ramelteon
26.67Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
26.67Single6TPJSuvorexant6TPJ-OX2-Suvorexant
26.67Single7F8ULintitript7F8U-CCKA-Lintitript
26.67Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
26.67Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
26.67Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
26.67Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
26.67Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
26.67Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
26.67Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
26.67Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
26.67Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
26.67Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
26.67Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
26.67Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
26.67Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
26.67Consensusangiotensin_offOrthosteric Ligandat1_off
26.67Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
26.67Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
26.67Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
26.67Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
26.67Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
26.67Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
26.32Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
26.32Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
26.32Single7K15MKD0467K15-BLT1-MKD046-Na
26.32Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
26.32Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
26.32Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
26.32Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
26.32Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
26.32Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.32Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
26.32Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
26.32Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
26.32Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
26.32Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
26.32Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
26.32Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
26.32Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
26.32Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
26.32Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
26.32Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
26.32Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
26.09Single3OE0CVX153OE0-CXCR4-CVX15
26.09Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
26.09Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
26.09Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
26.09Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
26.09Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
26.09Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
26.09Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
26.09Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
25.93Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
25.00Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
25.00Single3REYXAC3REY-A2A-XAC
25.00Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
25.00Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
25.00Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
25.00Single5GLHEndothelin-15GLH-ETB-Endothelin-1
25.00Single5UVIZM-2413855UVI-A2A-ZM-241385
25.00Single6K1QIRL25006K1Q-ETB-IRL2500
25.00Single6MH8ZM-2413856MH8-A2A-ZM-241385
25.00Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
25.00Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
25.00Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
25.00Single6TP3Nemorexant6TP3-OX1-Nemorexant
25.00Single6TPKRetosiban6TPK-OT-Retosiban
25.00Single6VI4JDTic6VI4-κ-JDTic
25.00Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
25.00Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
25.00Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
25.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
25.00Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
25.00Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
25.00Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
25.00Single7VODCariprazine7VOD-5-HT2A-Cariprazine
25.00Single7WC4Serotonin7WC4-5-HT2A-Serotonin
25.00Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
25.00Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
25.00Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
25.00Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
25.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
25.00Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
25.00Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
25.00Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
25.00Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
25.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
25.00Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
25.00Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
25.00Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
25.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
25.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single9BJKNaloxone9BJK-μ-Naloxone-NAM
25.00Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
25.00Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
25.00Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
25.00Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
25.00Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
25.00Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
25.00Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
25.00Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
25.00Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
25.00Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
25.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
25.00Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
25.00Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
25.00Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
25.00Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
25.00Consensusvasop-oxy_offOrthosteric Ligandot_off
25.00Consensusvasop-oxy_onOrthosteric Ligandv2_on
25.00Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
24.14Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
24.14Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
24.14Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
24.14Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
24.14Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
24.00Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
24.00Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
24.00Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
24.00Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
24.00Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
24.00Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
24.00Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.00Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
24.00Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
24.00Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
24.00Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
24.00Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
24.00Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
24.00Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
24.00Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
23.81Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
23.81Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
23.81Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
23.81Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
23.81Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
23.81Consensuskisspeptin_onOrthosteric Ligandkiss1_on
23.81Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
23.81Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
23.53Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
23.53Single6GPSMK08126GPS-CCR2-MK0812
23.53Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
23.53Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
23.53Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
23.53Single7F83PF-051904577F83-Ghrelin-PF-05190457
23.53Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
23.53Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
23.53Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
23.53Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
23.53Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
23.53Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
23.53Single9IYAONO-97105319IYA-GPR55-ONO-9710531
23.53Consensuscck_offOrthosteric Ligandccka_off
23.53Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
23.53Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
23.33Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
23.08Single3RFMCaffeine3RFM-A2A-Caffeine
23.08Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
23.08Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
23.08Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
23.08Single6TQ9SB-4081246TQ9-OX1-SB-408124
23.08Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
23.08Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
23.08Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
23.08Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
23.08Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
23.08Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
23.08Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
23.08Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
23.08Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
23.08Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
23.08Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
23.08Consensussensory_onOrthosteric Ligandopsins_on
22.73Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
22.73Single7QA8Peptide7QA8-STE2-Peptide
22.73Single7QA8Peptide7QA8-STE2-Peptide
22.73Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
22.73Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
22.73Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
22.73Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
22.73Single8WKYPG-9348WKY-MC4-PG-934
22.73Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
22.73Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
22.73Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
22.73Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
22.58Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
22.58Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
22.22Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
22.22Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
22.22Single5CGCHTL142425CGC-mGlu5-HTL14242
22.22Single6GPXMK08126GPX-CCR2-MK0812
22.22Single6HLPNetupitant6HLP-NK1-Netupitant
22.22Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
22.22Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
22.22Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
22.22Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
22.22Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
22.22Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
22.22Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
22.22Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
22.22Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
22.22Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
22.22Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
22.22Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.22Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
22.22Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
22.22Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
22.22Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
22.22Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
22.22Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
22.22Consensusblt_offOrthosteric Ligandblt1_off
22.22Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
21.74Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
21.74Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
21.74Single7XNACYN1548067XNA-SST2-CYN154806
21.74Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
21.74Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
21.74Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
21.74Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
21.74Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
21.74Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
21.74Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
21.43Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
21.43Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
21.43Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
21.43Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
21.43Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
21.43Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
21.43Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
21.43Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
21.43Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
21.43Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
21.43Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
21.43Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
21.43Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
21.43Single7WC5Psilocin7WC5-5-HT2A-Psilocin
21.43Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
21.43Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
21.43Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
21.43Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
21.43Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
21.43Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
21.43Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
21.43Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
21.43Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
21.43Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
21.43Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
21.43Consensusbradykinin_onOrthosteric Ligandbk2_on
21.43Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
21.43Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
21.43Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
21.43Consensusgi_sensoryOrthosteric Ligandgi_opsins
21.43Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
21.43Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
21.43Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
21.43Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
21.43Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
21.43Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
21.43Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
21.21Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
21.21Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
21.05Single5TZRMK86665TZR-FFA1-MK8666
21.05Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
21.05Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
21.05Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
21.05Single7FEECP559407FEE-CB1-CP55940-ZCZ011
21.05Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
21.05Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
21.05Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.05Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.05Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
21.05Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
21.05Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
21.05Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
21.05Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
21.05Single9BJKNAM9BJK-μ-Naloxone-NAM
21.05Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
21.05Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
21.05Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
21.05Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
21.05Consensuslpa_onOrthosteric Ligandlpa1_on
21.05Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
21.05Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
21.05Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
21.05Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
20.83Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
20.83Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
20.83Single6W25SHU91196W25-MC4-SHU9119-Ca
20.83Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
20.83Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
20.83Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
20.83Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
20.83Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
20.83Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
20.83Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
20.83Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
20.83Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
20.83Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
20.69Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
20.69Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
20.69Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
20.69Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
20.59Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
20.00Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
20.00Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
20.00Single4N4WSANT-14N4W-SMO-SANT-1
20.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
20.00Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
20.00Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
20.00Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
20.00Single6KQICP559406KQI-CB1-CP55940-Org27569
20.00Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
20.00Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
20.00Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
20.00Single6OS2TRV0266OS2-AT1-TRV026
20.00Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
20.00Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
20.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
20.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
20.00Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
20.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
20.00Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
20.00Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
20.00Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
20.00Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
20.00Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
20.00Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
20.00Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
20.00Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
20.00Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
20.00Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
20.00Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
20.00Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
20.00Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
20.00Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
20.00Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
20.00Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
20.00Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
20.00Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
20.00Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
20.00Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
20.00Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
20.00Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
20.00Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
20.00Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
20.00Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
20.00Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
20.00Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
20.00Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
20.00Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
19.35Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
19.35Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
19.23Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
19.23Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
19.23Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
19.23Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
19.23Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
19.05Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
19.05Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
19.05Single5CGDHTL142425CGD-mGlu5-HTL14242
19.05Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
19.05Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single8XVJMacitentan8XVJ-ETA-Macitentan
19.05Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
19.05Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
19.05Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.05Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.05Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
19.05Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
19.05Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
18.75Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
18.75Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
18.75Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
18.75Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
18.75Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
18.75Single5U09Taranabant5U09-CB1-Taranabant
18.75Single5ZKQABT-4915ZKQ-PAF-ABT-491
18.75Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
18.75Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
18.75Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
18.75Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
18.75Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
18.75Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
18.75Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
18.75Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
18.75Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
18.75Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
18.75Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
18.75Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
18.75Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.75Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
18.75Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
18.75Single9BA0A1AKN9BA0-CB1-A1AKN
18.75Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.75Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
18.52Single6FJ3PTH6FJ3-PTH1-PTH
18.52Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
18.52Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
18.52Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
18.52Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
18.52Single7SK3CXCL127SK3-ACKR3-CXCL12
18.52Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
18.52Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
18.52Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
18.52Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
18.52Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
18.52Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
18.52Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
18.18Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
18.18Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
18.18Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
18.18Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
18.18Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
18.18Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
18.18Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
18.18Single8IEIA1LYA8IEI-GPR156-A1LYA
18.18Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
18.18Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
18.18Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
18.18Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
18.18Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
17.95Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
17.86Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
17.86Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
17.86Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
17.86Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
17.86Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
17.86Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
17.86Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
17.86Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
17.65Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
17.65Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
17.65Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
17.65Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
17.65Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
17.65Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
17.65Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
17.65Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
17.65Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
17.65Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
17.65Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
17.65Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
17.65Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
17.39Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
17.39Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
17.39Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
17.39Single8IEIA1LYA8IEI-GPR156-A1LYA
17.39Single8IEPA1LYA8IEP-GPR156-A1LYA
17.39Single8IEPA1LYA8IEP-GPR156-A1LYA
17.39Single8KIGSHU91198KIG-MC3-SHU9119-Ca
17.39Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
17.39Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
17.39Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
17.39Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Consensussomatostatin_offOrthosteric Ligandsst2_off
17.24Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
17.24Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
17.24Single8IY6Endothelin-18IY6-ETB-Endothelin-1
17.24Consensusendothelin_onOrthosteric Ligandetb_on eta_on
16.67Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
16.67Single6IIVDaltroban6IIV-TP-Daltroban
16.67Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
16.67Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
16.67Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
16.67Single7SK5CXCL127SK5-ACKR3-CXCL12
16.67Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
16.67Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
16.67Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
16.67Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
16.67Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
16.67Single7YXAONO-54306087YXA-S1P5-ONO-5430608
16.67Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.67Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
16.67Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8IEBA1LYA8IEB-GPR156-A1LYA
16.67Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
16.67Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
16.67Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
16.67Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
16.67Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
16.67Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
16.67Single9B9ZA1AKO9B9Z-CB1-A1AKO
16.67Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
16.67Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
16.67Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
16.67Consensusblt_onOrthosteric Ligandblt1_on
16.67Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
16.67Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
16.67Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
16.67Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
16.67Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
16.67Consensusleukotriene_onOrthosteric Ligandblt_on
16.67Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
16.67Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
16.67Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
16.67Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
16.13Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
16.13Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
16.13Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
16.00Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
16.00Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
16.00Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
15.79Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
15.79Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
15.79Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
15.79Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
15.79Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
15.79Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
15.79Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
15.79Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
15.79Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
15.79Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
15.79Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
15.79Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
15.79Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
15.79Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
15.79Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
15.79Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
15.79Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
15.79Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
15.79Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
15.79Consensusep_offOrthosteric Ligandep4_off
15.79Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
15.79Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
15.62Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
15.62Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
15.62Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
15.62Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.38Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
15.38Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
15.38Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
15.38Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
15.38Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
15.38Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
15.38Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
15.38Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
15.38Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
15.38Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
15.38Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
15.38Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
15.15Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
15.00Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
15.00Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
15.00Single6OS1TRV0266OS1-AT1-TRV026
15.00Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
15.00Single7F1TMIP-1a7F1T-CCR5-MIP-1a
15.00Single7R0CAVP7R0C-V2-AVP-Arrestin2
15.00Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
15.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
15.00Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
15.00Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
15.00Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
15.00Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
15.00Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
15.00Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
15.00Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
15.00Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
15.00Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
15.00Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
15.00Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
14.81Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
14.81Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
14.81Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
14.81Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
14.81Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
14.29Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
14.29Single4PY02MeSATP4PY0-P2Y12-2MeSATP
14.29Single4XEENeurotensin4XEE-NTS1-Neurotensin
14.29Single4XESNeurotensin4XES-NTS1-Neurotensin
14.29Single5X33BIIL2605X33-BLT1-BIIL260
14.29Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
14.29Single6IIURamatroban6IIU-TP-Ramatroban
14.29Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
14.29Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
14.29Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
14.29Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
14.29Single6YVRNTS8-136YVR-NTS1-NTS8-13
14.29Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
14.29Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
14.29Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
14.29Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
14.29Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
14.29Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
14.29Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
14.29Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
13.79Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
13.79Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
13.79Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
13.64Single4BUONeurotensin4BUO-NTS1-Neurotensin
13.64Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
13.64Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
13.64Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
13.64Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
13.51Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
13.33Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
13.33Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
13.33Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
13.33Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
13.33Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
13.33Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
13.33Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
13.33Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.33Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
13.33Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
13.33Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
13.33Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
13.33Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
13.33Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
13.33Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
13.33Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
13.16Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
13.04Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
13.04Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
13.04Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.04Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
13.04Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
13.04Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
12.90Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
12.50Single5L7IVismodegib5L7I-SMO-Vismodegib
12.50Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
12.50Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
12.50Single6LI0C176LI0-GPR52-C17
12.50Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
12.50Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
12.50Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
12.50Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
12.50Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
12.50Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
12.50Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
12.50Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
12.50Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
12.50Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
12.50Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
12.50Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
12.50Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
12.50Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
12.00Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
12.00Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
12.00Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
12.00Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
12.00Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
11.76Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
11.76Single7BR3Elagolix7BR3-GnRH1-Elagolix
11.76Single7F8YDevazepide7F8Y-CCKA-Devazepide
11.76Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
11.76Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
11.76Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
11.76Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
11.76Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
11.76Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
11.76Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
11.76Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.76Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
11.76Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
11.76Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
11.76Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
11.54Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.54Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
11.54Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
11.54Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
11.11Single6FFIMMPEP6FFI-mGlu5-MMPEP
11.11Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
11.11Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
11.11Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
11.11Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
11.11Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
11.11Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
11.11Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8K2WAMG4878K2W-CXCR3-AMG487
11.11Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
11.11Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.11Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
11.11Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
11.11Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
11.11Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
11.11Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
11.11Consensusgrh_offOrthosteric Ligandgnrh1_off
11.11Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
10.71Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
10.71Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
10.71Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
10.71Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
10.53Single4QIMANTA XV4QIM-SMO-ANTA XV
10.53Single5T04Neurotensin5T04-NTS1-Neurotensin
10.53Single6FFHFenobam6FFH-mGlu5-Fenobam
10.53Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
10.53Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
10.53Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
10.53Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
10.53Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
10.53Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
10.53Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
10.53Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
10.53Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
10.53Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
10.53Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
10.53Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
10.00Single4JKVTaladegib4JKV-SMO-Taladegib
10.00Single4NTJAZD12834NTJ-P2Y12-AZD1283
10.00Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
10.00Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
10.00Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
10.00Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
10.00Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
10.00Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
9.52Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
9.52Single4BV0Neurotensin4BV0-NTS1-Neurotensin
9.52Single5V56TC1145V56-SMO-TC114
9.52Single5V57TC1145V57-SMO-TC114
9.52Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
9.52Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
9.52Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
9.52Single7P2L4YI7P2L-mGlu5-4YI
9.52Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.52Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
9.52Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
9.52Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
9.52Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
9.52Consensusneurotensin_onOrthosteric Ligandnts1_on
9.52Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
9.52Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
9.09Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
9.09Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
9.09Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
9.09Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
9.09Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
9.09Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
9.09Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
9.09Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
9.09Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
9.09Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
9.09Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
9.09Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
9.09Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
9.09Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
8.70Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
8.70Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
8.70Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
8.70Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
8.70Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
8.70Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
8.70Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
8.70Single8XVUCXCL28XVU-CXCR2-CXCL2
8.70Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
8.70Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
8.57Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
8.33Single6KNMJN241-96KNM-Apelin-JN241-9
8.33Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
8.33Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
8.33Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
8.33Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
8.33Single8XQJJN2418XQJ-Apelin-JN241
8.33Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
8.33Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
8.33Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
8.33Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
8.00Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
8.00Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
8.00Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
8.00Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.00Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
8.00Single8XWNCXCL88XWN-CXCR2-CXCL8
8.00Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
8.00Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
7.69Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
7.69Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
7.69Single7SHEPI; PE7SHE-GPR158-PI; PE
7.14Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
7.14Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
6.67Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
6.67Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
6.67Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Cholesterol-Gi1/β1/γ2
6.67Consensusp2y_offOrthosteric Ligandp2y1_off
6.25Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
6.25Single4XNWMRS25004XNW-P2Y1-MRS2500
6.25Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
6.25Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
6.25Single7V6A-7V6A-M4-PubChem 9864275-Gi1/β1/γ2
6.25Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
6.25Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
5.88Single4O9RCyclopamine4O9R-SMO-Cyclopamine
5.88Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
5.88Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
5.88Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
5.88Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
5.88Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
5.88Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
5.88Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single4BWBNeurotensin4BWB-NTS1-Neurotensin
5.56Single4QINSAG1.54QIN-SMO-SAG1.5
5.56Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
5.56Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
5.56Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
5.56Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
5.56Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
5.56Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
5.56Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
5.56Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
5.56Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
5.56Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
5.56Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
5.26Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
5.26Single6ZINSR486926ZIN-NTS1-SR48692
5.26Single7VV6C48/807VV6-MRGPRX2-C48/80
5.26Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
5.26Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single8IYXYL-3658IYX-GPR34-YL-365
5.26Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
5.00Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
5.00Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
5.00Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
5.00Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
5.00Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
5.00Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
4.76Single6Z4SSR486926Z4S-NTS1-SR48692
4.76Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
4.76Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
4.76Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
4.76Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
4.76Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
4.76Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
4.55Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
4.55Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
4.55Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
4.55Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
4.35Single7SHEPI; PE7SHE-GPR158-PI; PE
4.35Single8XQJJN2418XQJ-Apelin-JN241
4.35Single8XWACXCL18XWA-CXCR2-CXCL1
4.35Single8XWMCXCL68XWM-CXCR2-CXCL6
4.35Single8XWSCXCL58XWS-CXCR2-CXCL5
4.35Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
4.17Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
4.17Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
4.17Single8XWFCXCL38XWF-CXCR2-CXCL3
4.17Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
4.00Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
3.70Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7

PDB Summary
PDB 8JLQ
Class A
SubFamily Amine
Type Trace Amine Receptors
SubType TA1
Species Homo Sapiens
Ligand Fenoldopam
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 2.84
Date 2023-11-15
D.O.I. 10.1038/s41586-023-06804-z
Net Summary
Imin 3.49
Number of Linked Nodes 872
Number of Links 1040
Number of Hubs 159
Number of Links mediated by Hubs 591
Number of Communities 30
Number of Nodes involved in Communities 230
Number of Links involved in Communities 311
Path Summary
Number Of Nodes in MetaPath 144
Number Of Links MetaPath 143
Number of Shortest Paths 2755886
Length Of Smallest Path 3
Average Path Length 42.3588
Length of Longest Path 77
Minimum Path Strength 1.295
Average Path Strength 7.45427
Maximum Path Strength 24.545
Minimum Path Correlation 0.71
Average Path Correlation 0.988335
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.32558
Average % Of Corr. Nodes 34.0875
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 49.3351
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• D2 dopamine receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • molecular function regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • catalytic activity   • adenylate cyclase activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • D1 dopamine receptor binding   • molecular function activator activity   • enzyme activator activity   • cyclase activator activity   • adenylate cyclase activator activity   • mu-type opioid receptor binding   • opioid receptor binding   • beta-2 adrenergic receptor binding   • adrenergic receptor binding   • ionotropic glutamate receptor binding   • glutamate receptor binding   • peptide hormone receptor binding   • corticotropin-releasing hormone receptor binding   • corticotropin-releasing hormone receptor 1 binding   • hormone receptor binding   • neuropeptide receptor binding   • insulin-like growth factor receptor binding   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • protein localization   • positive regulation of protein localization to cell periphery   • regulation of localization   • protein localization to cell periphery   • cellular localization   • regulation of protein localization   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • localization   • regulation of cellular localization   • regulation of protein localization to cell cortex   • cellular macromolecule localization   • macromolecule localization   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • cellular response to nitrogen compound   • cellular response to peptide hormone stimulus   • response to glucagon   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • homeostatic process   • adaptive thermogenesis   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • establishment of protein localization   • nitrogen compound transport   • regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • regulation of hormone secretion   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • serotonin receptor signaling pathway   • adenylate cyclase-activating serotonin receptor signaling pathway   • midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle
Gene OntologyCellular Component• midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle   • nuclear lumen   • cell periphery   • cell cortex   • cytoplasm   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • endomembrane system   • cilium   • plasma membrane bounded cell projection   • ciliary basal body   • cell projection   • Golgi apparatus subcompartment   • organelle subcompartment   • trans-Golgi network membrane   • trans-Golgi network   • apical part of cell   • plasma membrane region   • apical plasma membrane   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • synapse   • cell junction   • tetrapyrrole binding   • heme binding   • electron transfer activity   • cation binding   • transition metal ion binding   • iron ion binding   • ion binding   • metal ion binding   • small molecule binding   • G protein-coupled amine receptor activity   • molecular transducer activity   • trace-amine receptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • electron transport chain   • metabolic process   • generation of precursor metabolites and energy   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • periplasmic space   • endoplasmic reticulum subcompartment   • nuclear outer membrane-endoplasmic reticulum membrane network   • endoplasmic reticulum   • endoplasmic reticulum membrane   • G-protein beta-subunit binding   • fibroblast proliferation
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeG3C
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeG3C
Name(1R)-6-chloranyl-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol
Synonyms
Identifier
FormulaC16 H16 Cl N O3
Molecular Weight305.756
SMILES
PubChem30026875
Formal Charge0
Total Atoms37
Total Chiral Atoms1
Total Bonds39
Total Aromatic Bonds12

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8JLQ_Chain_A
RNEEKAQRE ANKKIEKQL QKDKQVYRA THRLLLLGA GESGKNTIV 
KQMRISGIF ETKFQVDKV NFHMFDVGA QRDERRKWI QCFNDVTAI 
IFVVASSSY NTNRLQAAL KLFDSIWNN KWLRDTSVI LFLNKQDLL 
AEKVLAGKS KIEDYFPEF ARYTTPEDA TPEPGEDPR VTRAKYFIR 
DEFLRISTA RHYCYPHFT CSVDTENIR RVFNDCRDI IQRMHLRQY 
ELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8JLQ_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8JLQ_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFRE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ96RJ0
Sequence
>8JLQ_Chain_R
VRASLYSLM VLIILTTLV GNLIVIVSI SHFKQLHTP TNWLIHSMA 
TVDFLLGCL VMPYSMVRS AEHCWYFGE VFCKIHTST DIMLSSASI 
FHLSFISID RYYAVCDPL RYKAKMNIL VICVMIFIS WSVPAVFAF 
GMIFLELNF KGAEEIYYK HVHCRGGCS VFFSKISGV LTFMTSFYI 
PGSIMLCVY YRIYLIAKE QARLISDAN QKLQKAVKT LGIVMGVFL 
ICWCPFFIC TVMDPFLHY IIPPTLNDV LIWFGYLNS TFNPMVYAF 
FYPWFRKAL KMML


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9JKQAAmineTrace Amine ReceptorsTA1Homo sapiensMETH-Gs/β1/γ22.662024-10-16doi.org/10.1021/acs.jmedchem.4c01961
9JKQ (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensMETH-2.662024-10-16doi.org/10.1021/acs.jmedchem.4c01961
8ZSVAAmineTrace Amine ReceptorsTA1Mus musculusRO5263397-chim(NtGi1-Gs)/β1/γ22.962024-07-2410.1016/j.celrep.2024.114505
8ZSV (No Gprot) AAmineTrace Amine ReceptorsTA1Mus musculusRO5263397-2.962024-07-2410.1016/j.celrep.2024.114505
8ZSSAAmineTrace Amine ReceptorsTA1Homo sapiensRO5263397-chim(NtGi1-Gs)/β1/γ23.072024-07-2410.1016/j.celrep.2024.114505
8ZSS (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensRO5263397-3.072024-07-2410.1016/j.celrep.2024.114505
8ZSPAAmineTrace Amine ReceptorsTA1Homo sapiensLSD-chim(NtGi1L-Gs-CtGq)/β1/γ23.142024-07-2410.1016/j.celrep.2024.114505
8ZSP (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensLSD-3.142024-07-2410.1016/j.celrep.2024.114505
8ZSJAAmineTrace Amine ReceptorsTA1Homo sapiens--chim(NtGi1L-Gs-CtGq)/β1/γ22.82024-07-2410.1016/j.celrep.2024.114505
8ZSJ (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiens--2.82024-07-2410.1016/j.celrep.2024.114505
8UHBAAmineTrace Amine ReceptorsTA1Homo sapiensRO5256390-Gs/β1/γ23.352024-01-1010.1038/s41467-023-44601-4
8UHB (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensRO5256390-3.352024-01-1010.1038/s41467-023-44601-4
8WCCAAmineTrace Amine ReceptorsTA1Mus musculusCyclohexylammonium Ion--3.042023-12-2710.1016/j.cell.2023.10.014
8WCBAAmineTrace Amine ReceptorsTA1Mus musculusCyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ23.12023-12-2710.1016/j.cell.2023.10.014
8WCB (No Gprot) AAmineTrace Amine ReceptorsTA1Mus musculusCyclohexylammonium Ion-3.12023-12-2710.1016/j.cell.2023.10.014
8WC9AAmineTrace Amine ReceptorsTA1Mus musculusZH8651-chim(NtGi1-Gs-CtGq)/β1/γ23.22023-12-2710.1016/j.cell.2023.10.014
8WC9 (No Gprot) AAmineTrace Amine ReceptorsTA1Mus musculusZH8651-3.22023-12-2710.1016/j.cell.2023.10.014
8WCAAAmineTrace Amine ReceptorsTA1Homo sapiens2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ23.482023-12-2710.1016/j.cell.2023.10.014
8WCA (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiens2-Phenylethylamine-3.482023-12-2710.1016/j.cell.2023.10.014
8WC8AAmineTrace Amine ReceptorsTA1Homo sapiensZH8651-chim(NtGi1-Gs)/β1/γ22.92023-12-2710.1016/j.cell.2023.10.014
8WC8 (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensZH8651-2.92023-12-2710.1016/j.cell.2023.10.014
8WC7AAmineTrace Amine ReceptorsTA1Mus musculusZH8667-chim(NtGi1-Gs)/β1/γ23.12023-12-2710.1016/j.cell.2023.10.014
8WC7 (No Gprot) AAmineTrace Amine ReceptorsTA1Mus musculusZH8667-3.12023-12-2710.1016/j.cell.2023.10.014
8WC6AAmineTrace Amine ReceptorsTA1Mus musculus2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ23.22023-12-2710.1016/j.cell.2023.10.014
8WC6 (No Gprot) AAmineTrace Amine ReceptorsTA1Mus musculus2-Phenylethylamine-3.22023-12-2710.1016/j.cell.2023.10.014
8WC5AAmineTrace Amine ReceptorsTA1Mus musculusTetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ23.32023-12-2710.1016/j.cell.2023.10.014
8WC5 (No Gprot) AAmineTrace Amine ReceptorsTA1Mus musculusTetramethylammonium Ion-3.32023-12-2710.1016/j.cell.2023.10.014
8WC4AAmineTrace Amine ReceptorsTA1Mus musculusZH8651-chim(NtGi1-Gs)/β1/γ23.12023-12-2710.1016/j.cell.2023.10.014
8WC4 (No Gprot) AAmineTrace Amine ReceptorsTA1Mus musculusZH8651-3.12023-12-2710.1016/j.cell.2023.10.014
8WC3AAmineTrace Amine ReceptorsTA1Mus musculusSEP-363856-chim(NtGi1-Gs)/β1/γ232023-12-2710.1016/j.cell.2023.10.014
8WC3 (No Gprot) AAmineTrace Amine ReceptorsTA1Mus musculusSEP-363856-32023-12-2710.1016/j.cell.2023.10.014
8W8AAAmineTrace Amine ReceptorsTA1Homo sapiensRO5256390-chim(NtGi1L-Gs)/β1/γ22.82023-11-2210.1038/s41586-023-06775-1
8W8A (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensRO5256390-2.82023-11-2210.1038/s41586-023-06775-1
8W89AAmineTrace Amine ReceptorsTA1Homo sapiensPEA-chim(NtGi1L-Gs)/β1/γ232023-11-2210.1038/s41586-023-06775-1
8W89 (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensPEA-32023-11-2210.1038/s41586-023-06775-1
8W87AAmineTrace Amine ReceptorsTA1Homo sapiensMETH-chim(NtGi1L-Gs)/β1/γ22.82023-11-2210.1038/s41586-023-06775-1
8W87 (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensMETH-2.82023-11-2210.1038/s41586-023-06775-1
8W88AAmineTrace Amine ReceptorsTA1Homo sapiensSEP-363856-Gs/β1/γ22.62023-11-2210.1038/s41586-023-06775-1
8W88 (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensSEP-363856-2.62023-11-2210.1038/s41586-023-06775-1
8JSOAAmineTrace Amine ReceptorsTA1Homo sapiensAMPH-chim(NtGi1-Gs)/β1/γ23.42023-11-1510.1038/s41586-023-06804-z
8JSO (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensAMPH-3.42023-11-1510.1038/s41586-023-06804-z
8JLRAAmineTrace Amine ReceptorsTA1Homo sapiensA77636-chim(NtGi1-Gs)/β1/γ232023-11-1510.1038/s41586-023-06804-z
8JLR (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensA77636-32023-11-1510.1038/s41586-023-06804-z
8JLKAAmineTrace Amine ReceptorsTA1Mus musculusUlotaront-chim(NtGi1-Gs)/β1/γ23.222023-11-1510.1038/s41586-023-06804-z
8JLK (No Gprot) AAmineTrace Amine ReceptorsTA1Mus musculusUlotaront-3.222023-11-1510.1038/s41586-023-06804-z
8JLJAAmineTrace Amine ReceptorsTA1Mus musculusT1AM-chim(NtGi1-Gs)/β1/γ23.12023-11-1510.1038/s41586-023-06804-z
8JLJ (No Gprot) AAmineTrace Amine ReceptorsTA1Mus musculusT1AM-3.12023-11-1510.1038/s41586-023-06804-z
8JLQAAmineTrace Amine ReceptorsTA1Homo sapiensFenoldopam-Gs/β1/γ22.842023-11-1510.1038/s41586-023-06804-z
8JLQ (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensFenoldopam-2.842023-11-1510.1038/s41586-023-06804-z
8JLPAAmineTrace Amine ReceptorsTA1Homo sapiensRalmitaront-Gs/β1/γ23.232023-11-1510.1038/s41586-023-06804-z
8JLP (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensRalmitaront-3.232023-11-1510.1038/s41586-023-06804-z
8JLOAAmineTrace Amine ReceptorsTA1Homo sapiensUlotaront-Gs/β1/γ23.522023-11-1510.1038/s41586-023-06804-z
8JLO (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensUlotaront-3.522023-11-1510.1038/s41586-023-06804-z
8JLNAAmineTrace Amine ReceptorsTA1Homo sapiensT1AM-Gs/β1/γ23.242023-11-1510.1038/s41586-023-06804-z
8JLN (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensT1AM-3.242023-11-1510.1038/s41586-023-06804-z




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