psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D103	17.36	Yes	Yes	1	0	6
2	L:L:?1	R:R:I104	8.12	Yes	No	0	0	4
3	L:L:?1	R:R:S107	11.74	Yes	No	1	0	6
4	L:L:?1	R:R:V184	4.24	Yes	No	0	0	4
5	L:L:?1	R:R:S198	4.27	Yes	No	0	0	6
6	L:L:?1	R:R:W264	12.14	Yes	Yes	1	0	8
7	L:L:?1	R:R:F267	10.39	Yes	Yes	1	0	5
8	L:L:?1	R:R:F268	4.33	Yes	Yes	1	0	7
9	L:L:?1	R:R:I290	8.12	Yes	No	1	0	5
10	L:L:?1	R:R:Y294	17.5	Yes	Yes	1	0	7
11	R:R:N20	R:R:S19	4.47	No	No	0	5	2
12	R:R:S19	R:R:V22	4.85	No	No	0	2	3
13	R:R:D21	R:R:N20	9.42	No	No	0	4	5
14	R:R:R23	R:R:Y27	9.26	No	Yes	0	4	6
15	R:R:M81	R:R:Y27	4.79	Yes	Yes	0	6	6
16	R:R:V82	R:R:Y27	6.31	No	Yes	0	5	6
17	R:R:A85	R:R:Y27	6.67	No	Yes	0	5	6
18	R:R:E86	R:R:Y27	10.1	No	Yes	0	4	6
19	R:R:M30	R:R:M81	10.11	No	Yes	0	6	6
20	R:R:M30	R:R:W291	16.29	No	Yes	0	6	4
21	R:R:I33	R:R:L295	5.71	No	No	0	7	5
22	R:R:I34	R:R:M77	4.37	No	Yes	0	6	7
23	R:R:I34	R:R:M81	4.37	No	Yes	0	6	6
24	R:R:M77	R:R:T37	7.53	Yes	No	0	7	7
25	R:R:T298	R:R:T37	9.42	No	No	0	7	7
26	R:R:F70	R:R:L38	3.65	Yes	No	5	7	6
27	R:R:C74	R:R:L38	6.35	No	No	5	4	6
28	R:R:G40	R:R:V39	3.68	No	No	0	9	5
29	R:R:D69	R:R:N41	8.08	Yes	No	0	9	9
30	R:R:F70	R:R:N41	4.83	Yes	No	0	7	9
31	R:R:N41	R:R:P301	13.03	No	No	0	9	9
32	R:R:F70	R:R:L42	6.09	Yes	No	0	7	4
33	R:R:F306	R:R:I43	3.77	No	No	0	6	7
34	R:R:F311	R:R:V44	6.55	Yes	No	0	9	9
35	R:R:H63	R:R:I45	9.28	Yes	No	2	6	8
36	R:R:I45	R:R:T67	6.08	No	No	2	8	6
37	R:R:F311	R:R:S47	6.61	Yes	No	6	9	8
38	R:R:L315	R:R:S47	6.01	No	No	6	7	8
39	R:R:H63	R:R:I48	9.28	Yes	No	0	6	7
40	R:R:F311	R:R:I48	3.77	Yes	No	0	9	7
41	R:R:F51	R:R:H50	6.79	Yes	No	0	5	5
42	R:R:F51	R:R:Q53	11.71	Yes	No	7	5	5
43	R:R:F51	R:R:L54	6.09	Yes	No	7	5	8
44	R:R:A314	R:R:F51	4.16	No	Yes	0	7	5
45	R:R:F51	R:R:M317	3.73	Yes	No	0	5	5
46	R:R:F51	R:R:M318	7.46	Yes	No	0	5	6
47	R:R:L54	R:R:Q53	5.32	No	No	7	8	5
48	R:R:L54	R:R:N59	4.12	No	No	0	8	9
49	R:R:H55	R:R:W60	12.7	No	No	0	8	4
50	R:R:N59	R:R:T56	8.77	No	No	0	9	8
51	R:R:I137	R:R:P57	5.08	No	No	0	2	6
52	R:R:I140	R:R:P57	6.77	No	No	0	7	6
53	R:R:D120	R:R:T58	11.56	No	No	4	9	8
54	R:R:T58	R:R:Y131	4.99	No	Yes	4	8	7
55	R:R:H63	R:R:W60	6.35	Yes	No	0	6	4
56	R:R:I137	R:R:W60	4.7	No	No	0	2	4
57	R:R:I117	R:R:L61	5.71	Yes	No	0	9	7
58	R:R:H63	R:R:T67	4.11	Yes	No	2	6	6
59	R:R:H113	R:R:S64	11.16	Yes	No	2	8	9
60	R:R:I144	R:R:S64	10.84	No	No	0	7	9
61	R:R:S64	R:R:W148	4.94	No	Yes	2	9	9
62	R:R:H113	R:R:M65	7.88	Yes	No	0	8	9
63	R:R:I117	R:R:M65	4.37	Yes	No	0	9	9
64	R:R:M65	R:R:N300	4.21	No	Yes	0	9	9
65	R:R:T67	R:R:W148	6.06	No	Yes	2	6	9
66	R:R:H113	R:R:V68	4.15	Yes	No	2	8	8
67	R:R:V68	R:R:W148	8.58	No	Yes	2	8	9
68	R:R:D69	R:R:S110	5.89	Yes	No	0	9	9
69	R:R:D69	R:R:S297	8.83	Yes	No	0	9	9
70	R:R:D69	R:R:N300	8.08	Yes	Yes	0	9	9
71	R:R:C74	R:R:F70	8.38	No	Yes	5	4	7
72	R:R:L72	R:R:V76	4.47	No	Yes	0	7	7
73	R:R:L106	R:R:L72	9.69	No	No	0	6	7
74	R:R:L72	R:R:S297	4.5	No	No	0	7	9
75	R:R:G73	R:R:M77	6.99	No	Yes	0	7	7
76	R:R:H99	R:R:V76	8.3	No	Yes	0	5	7
77	R:R:D103	R:R:V76	10.22	Yes	Yes	1	6	7
78	R:R:V76	R:R:Y294	5.05	Yes	Yes	1	7	7
79	R:R:M77	R:R:Y294	7.18	Yes	Yes	0	7	7
80	R:R:F91	R:R:Y79	4.13	No	No	3	6	5
81	R:R:F95	R:R:Y79	9.28	No	No	3	5	5
82	R:R:H99	R:R:Y79	6.53	No	No	0	5	5
83	R:R:R83	R:R:S80	5.27	No	No	0	4	6
84	R:R:S80	R:R:Y294	8.9	No	Yes	0	6	7
85	R:R:R83	R:R:W89	7	No	Yes	0	4	7
86	R:R:D287	R:R:S84	8.83	No	No	0	3	5
87	R:R:S84	R:R:W291	6.18	No	Yes	0	5	4
88	R:R:E86	R:R:Y90	6.73	No	No	0	4	1
89	R:R:H87	R:R:R179	6.77	No	No	0	4	2
90	R:R:C88	R:R:Y90	14.79	No	No	0	4	1
91	R:R:F91	R:R:W89	22.05	No	Yes	3	6	7
92	R:R:F95	R:R:W89	4.01	No	Yes	3	5	7
93	R:R:C96	R:R:W89	5.22	No	Yes	3	9	7
94	R:R:H99	R:R:W89	10.58	No	Yes	0	5	7
95	R:R:C182	R:R:W89	14.37	No	Yes	3	9	7
96	R:R:F91	R:R:F95	9.65	No	No	3	6	5
97	R:R:C182	R:R:C96	5.46	No	No	3	9	9
98	R:R:F160	R:R:K97	7.44	Yes	No	0	4	6
99	R:R:E162	R:R:K97	8.1	No	No	0	5	6
100	R:R:F160	R:R:I98	3.77	Yes	No	0	4	4
101	R:R:I159	R:R:T100	6.08	No	No	0	6	4
102	R:R:F156	R:R:S101	9.25	No	No	9	4	6
103	R:R:I159	R:R:S101	6.19	No	No	0	6	6
104	R:R:F160	R:R:S101	6.61	Yes	No	9	4	6
105	R:R:D103	R:R:S107	4.42	Yes	No	1	6	6
106	R:R:D103	R:R:Y294	6.9	Yes	Yes	1	6	7
107	R:R:F156	R:R:M105	3.73	No	No	0	4	5
108	R:R:S107	R:R:W264	3.71	No	Yes	1	6	8
109	R:R:S108	R:R:S198	6.52	No	No	0	5	6
110	R:R:I111	R:R:W264	11.74	No	Yes	0	8	8
111	R:R:F112	R:R:S147	3.96	No	No	0	6	7
112	R:R:F112	R:R:P151	8.67	No	No	0	6	8
113	R:R:F112	R:R:P202	5.78	No	No	0	6	9
114	R:R:H113	R:R:S147	15.34	Yes	No	0	8	7
115	R:R:H113	R:R:W148	4.23	Yes	Yes	2	8	9
116	R:R:L114	R:R:N300	8.24	No	Yes	0	9	9
117	R:R:L114	R:R:Y304	5.86	No	Yes	0	9	9
118	R:R:F116	R:R:M143	18.66	No	No	0	7	6
119	R:R:F116	R:R:I146	3.77	No	No	0	7	3
120	R:R:I117	R:R:R121	5.01	Yes	No	8	9	9
121	R:R:I117	R:R:Y304	6.04	Yes	Yes	8	9	9
122	R:R:M206	R:R:S118	4.6	No	No	0	9	8
123	R:R:S118	R:R:Y210	5.09	No	Yes	0	8	9
124	R:R:D120	R:R:Y131	10.34	No	Yes	4	9	7
125	R:R:D120	R:R:M135	8.32	No	Yes	4	9	7
126	R:R:R121	R:R:Y304	4.12	No	Yes	8	9	9
127	R:R:R121	R:R:Y308	11.32	No	Yes	0	9	8
128	R:R:C126	R:R:Y122	13.44	No	No	0	6	8
129	R:R:V209	R:R:Y122	7.57	No	No	0	7	8
130	R:R:R212	R:R:Y122	11.32	No	No	0	5	8
131	R:R:M135	R:R:Y123	5.99	Yes	No	0	7	4
132	R:R:A124	R:R:Y131	8.01	No	Yes	0	8	7
133	R:R:I216	R:R:V125	4.61	No	No	0	5	8
134	R:R:D127	R:R:R130	13.1	No	No	10	5	5
135	R:R:D127	R:R:K134	5.53	No	No	10	5	4
136	R:R:K134	R:R:R130	3.71	No	No	10	4	5
137	R:R:M135	R:R:Y131	4.79	Yes	Yes	4	7	7
138	R:R:N136	R:R:V139	4.43	No	No	0	8	5
139	R:R:M143	R:R:V139	4.56	No	No	0	6	5
140	R:R:F145	R:R:S149	11.89	No	No	0	5	4
141	R:R:F154	R:R:M158	6.22	Yes	No	0	4	5
142	R:R:F154	R:R:L193	3.65	Yes	No	0	4	3
143	R:R:F154	R:R:T194	6.49	Yes	No	0	4	5
144	R:R:F154	R:R:T197	11.67	Yes	No	0	4	4
145	R:R:F156	R:R:F160	4.29	No	Yes	9	4	4
146	R:R:F186	R:R:M158	3.73	Yes	No	0	1	5
147	R:R:I159	R:R:N164	4.25	No	No	0	6	4
148	R:R:E162	R:R:F165	12.83	No	Yes	0	5	4
149	R:R:F165	R:R:N164	7.25	Yes	No	0	4	4
150	R:R:F165	R:R:Y172	36.1	Yes	No	0	4	3
151	R:R:E169	R:R:G167	4.91	No	No	0	4	4
152	R:R:F185	R:R:I171	3.77	Yes	No	0	1	2
153	R:R:V176	R:R:Y172	8.83	No	No	0	3	3
154	R:R:F185	R:R:Y172	15.47	Yes	No	0	1	3
155	R:R:H175	R:R:S183	11.16	No	No	0	3	4
156	R:R:F185	R:R:H175	10.18	Yes	No	0	1	3
157	R:R:R179	R:R:S183	6.59	No	No	0	2	4
158	R:R:F186	R:R:V184	5.24	Yes	No	0	1	4
159	R:R:F185	R:R:Y279	9.28	Yes	No	0	1	1
160	R:R:F186	R:R:S190	5.28	Yes	No	0	1	6
161	R:R:F186	R:R:T194	9.08	Yes	No	0	1	5
162	R:R:I189	R:R:S187	4.64	No	No	0	4	4
163	R:R:S187	R:R:S190	4.89	No	No	0	4	6
164	R:R:F276	R:R:K188	8.69	No	No	0	5	3
165	R:R:F195	R:R:M196	6.22	Yes	No	1	5	5
166	R:R:F195	R:R:F199	8.57	Yes	Yes	1	5	8
167	R:R:F195	R:R:Y200	6.19	Yes	No	1	5	5
168	R:R:F195	R:R:F268	5.36	Yes	Yes	1	5	7
169	R:R:F195	R:R:V272	11.8	Yes	No	0	5	6
170	R:R:M196	R:R:Y200	4.79	No	No	1	5	5
171	R:R:F199	R:R:F260	5.36	Yes	Yes	1	8	9
172	R:R:F199	R:R:W264	4.01	Yes	Yes	1	8	8
173	R:R:C265	R:R:F199	5.59	No	Yes	0	6	8
174	R:R:F199	R:R:F268	19.29	Yes	Yes	1	8	7
175	R:R:F260	R:R:M206	13.68	Yes	No	0	9	9
176	R:R:L207	R:R:M257	4.24	No	No	0	5	8
177	R:R:L253	R:R:Y210	4.69	No	Yes	0	7	9
178	R:R:V256	R:R:Y210	5.05	No	Yes	0	8	9
179	R:R:M257	R:R:Y210	7.18	No	Yes	0	8	9
180	R:R:Y210	R:R:Y304	3.97	Yes	Yes	0	9	9
181	R:R:L215	R:R:Y211	10.55	No	No	0	4	3
182	R:R:I216	R:R:R212	5.01	No	No	0	5	5
183	R:R:K218	R:R:Y214	10.75	No	Yes	0	6	5
184	R:R:K218	R:R:R247	7.43	No	No	0	6	5
185	R:R:L223	R:R:R222	4.86	No	No	0	4	4
186	R:R:Q229	R:R:S225	4.33	No	No	0	3	4
187	R:R:R247	R:R:V250	9.15	No	No	0	5	8
188	R:R:F307	R:R:K251	6.2	No	No	0	7	6
189	R:R:F307	R:R:T252	6.49	No	No	0	7	9
190	R:R:F299	R:R:V259	3.93	No	No	0	6	6
191	R:R:F260	R:R:W264	7.02	Yes	Yes	1	9	8
192	R:R:C263	R:R:N296	7.87	No	No	0	8	9
193	R:R:F268	R:R:W264	5.01	Yes	Yes	1	7	8
194	R:R:G293	R:R:W264	5.63	No	Yes	0	7	8
195	R:R:N296	R:R:W264	14.69	No	Yes	0	9	8
196	R:R:F267	R:R:F268	5.36	Yes	Yes	1	5	7
197	R:R:F267	R:R:T271	11.67	Yes	No	0	5	5
198	R:R:F267	R:R:L289	3.65	Yes	Yes	0	5	5
199	R:R:F267	R:R:I290	6.28	Yes	No	1	5	5
200	R:R:L277	R:R:M273	5.65	No	No	0	3	4
201	R:R:D274	R:R:Y279	5.75	No	No	0	2	1
202	R:R:D274	R:R:I281	8.4	No	Yes	0	2	2
203	R:R:P275	R:R:Y279	4.17	No	No	0	4	1
204	R:R:I281	R:R:L285	4.28	Yes	No	0	2	4
205	R:R:L285	R:R:L289	5.54	No	Yes	0	4	5
206	R:R:W291	R:R:Y294	9.65	Yes	Yes	0	4	7
207	R:R:F299	R:R:L295	6.09	No	No	0	6	5
208	R:R:N296	R:R:N300	12.26	No	Yes	0	9	9
209	R:R:V303	R:R:Y304	5.05	No	Yes	0	8	9
210	R:R:A305	R:R:F311	8.32	No	Yes	0	7	9
211	R:R:F306	R:R:F311	5.36	No	Yes	0	6	9
212	R:R:P309	R:R:Y308	4.17	No	Yes	0	5	8
213	R:R:W310	R:R:Y308	12.54	No	Yes	0	6	8
214	R:R:F311	R:R:L315	4.87	Yes	No	6	9	7
215	R:R:K134	R:R:Y123	3.58	No	No	0	4	4
216	R:R:P202	R:R:S115	3.56	No	No	0	9	7
217	R:R:P151	R:R:V150	3.53	No	No	0	8	4
218	R:R:I33	R:R:W291	3.52	No	Yes	0	7	4
219	R:R:L215	R:R:Y214	3.52	No	Yes	0	4	5
220	R:R:P57	R:R:T56	3.5	No	No	0	6	8
221	R:R:P282	R:R:T284	3.5	No	No	0	1	3
222	R:R:L71	R:R:W148	3.42	No	Yes	0	7	9
223	R:R:G157	R:R:L161	3.42	No	No	0	6	4
224	R:R:A66	R:R:V44	3.39	No	No	0	9	9
225	R:R:A109	R:R:V68	3.39	No	No	0	7	8
226	R:R:I201	R:R:P202	3.39	No	No	0	6	9
227	R:R:I281	R:R:P282	3.39	Yes	No	0	2	1
228	R:R:K188	R:R:P275	3.35	No	No	0	3	4
229	R:R:L289	R:R:P266	3.28	Yes	No	0	5	9
230	R:R:C141	R:R:I137	3.27	No	No	0	1	2
231	R:R:A155	R:R:I104	3.25	No	No	0	6	4
232	R:R:S118	R:R:V209	3.23	No	No	0	8	7
233	R:R:S149	R:R:V150	3.23	No	No	0	4	4
234	R:R:A152	R:R:M105	3.22	No	No	0	3	5
235	R:R:C270	R:R:L289	3.17	No	Yes	0	4	5
236	R:R:T298	R:R:T36	3.14	No	No	0	7	5
237	R:R:F307	R:R:Y308	3.09	No	Yes	0	7	8
238	R:R:I43	R:R:V39	3.07	No	No	0	7	5
239	R:R:I146	R:R:V142	3.07	No	No	0	3	3
240	R:R:M135	R:R:V139	3.04	Yes	No	0	7	5
241	R:R:F186	R:R:G191	3.01	Yes	No	0	1	4
242	R:R:F260	R:R:G203	3.01	Yes	No	0	9	6
243	R:R:G180	R:R:R179	3	No	No	0	4	2
244	R:R:L26	R:R:V22	2.98	No	No	0	5	3
245	R:R:L42	R:R:V46	2.98	No	No	0	4	4
246	R:R:L32	R:R:T36	2.95	No	No	0	5	5
247	R:R:L106	R:R:T102	2.95	No	No	0	6	4
248	R:R:I48	R:R:I62	2.94	No	No	0	7	8
249	R:R:I117	R:R:I62	2.94	Yes	No	0	9	8
250	R:R:I119	R:R:I205	2.94	No	No	0	6	6
251	R:R:I140	R:R:M135	2.92	No	Yes	0	7	7
252	R:R:I269	R:R:M273	2.92	No	No	0	6	4
253	R:R:I255	R:R:K251	2.91	No	No	0	6	6
254	R:R:I33	R:R:L29	2.85	No	No	0	7	5
255	R:R:I213	R:R:L253	2.85	No	No	0	9	7
256	R:R:L261	R:R:M257	2.83	No	No	0	6	8
257	R:R:H63	R:R:S49	2.79	Yes	No	0	6	3
258	R:R:A168	R:R:F185	2.77	No	Yes	0	3	1
259	R:R:H55	R:R:K52	2.62	No	No	0	8	6
260	R:R:F292	R:R:V288	2.62	No	No	0	7	4
261	R:R:F299	R:R:M302	2.49	No	No	0	6	6
262	R:R:F276	R:R:L277	2.44	No	No	0	5	3
263	R:R:I119	R:R:Y123	2.42	No	No	0	6	4
264	R:R:F267	R:R:N286	2.42	Yes	No	0	5	4
265	R:R:E169	R:R:F165	2.33	No	Yes	0	4	4
266	R:R:G180	R:R:G181	2.11	No	No	0	4	3
267	R:R:P282	R:R:P283	1.95	No	No	0	1	1
268	R:R:A217	R:R:A249	1.79	No	No	0	8	8
269	R:R:M77	R:R:P78	1.68	Yes	No	0	7	8
270	R:R:C178	R:R:K174	1.62	No	No	0	4	4
271	R:R:D127	R:R:P128	1.61	No	No	0	5	8
272	R:R:V192	R:R:V272	1.6	No	No	0	5	6
273	R:R:C74	R:R:L75	1.59	No	No	0	4	5
274	R:R:I205	R:R:S204	1.55	No	No	0	6	4
275	R:R:I98	R:R:V94	1.54	No	No	0	4	1
276	R:R:M81	R:R:V31	1.52	Yes	No	0	6	5
277	R:R:L35	R:R:V31	1.49	No	No	0	5	5
278	R:R:L138	R:R:V142	1.49	No	No	0	4	3
279	R:R:C178	R:R:H177	1.47	No	No	0	4	4
280	R:R:I280	R:R:I281	1.47	No	Yes	0	1	2
281	R:R:P309	R:R:R312	1.44	No	No	0	5	8
282	R:R:K313	R:R:M317	1.44	No	No	0	5	5
283	R:R:L26	R:R:M30	1.41	No	No	0	5	6
284	R:R:L163	R:R:M158	1.41	No	No	0	6	5
285	R:R:K166	R:R:L163	1.41	No	No	0	3	6
286	R:R:L161	R:R:L163	1.38	No	No	0	4	6
287	R:R:I216	R:R:Q220	1.37	No	No	0	5	6
288	R:R:A249	R:R:Y214	1.33	No	Yes	0	8	5
289	R:R:N228	R:R:Q229	1.32	No	No	0	4	3
290	R:R:N228	R:R:Q232	1.32	No	No	0	4	5
291	R:R:F292	R:R:L295	1.22	No	No	0	7	5
292	R:R:K132	R:R:Y131	1.19	No	Yes	0	4	7
293	R:R:L253	R:R:Y214	1.17	No	Yes	0	7	5
294	R:R:E219	R:R:R222	1.16	No	No	0	3	4
295	R:R:E169	R:R:Y173	1.12	No	No	0	4	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.821	10	1	0
2	R:R:Y27	7.426	5	0	6
3	R:R:F51	6.65667	6	7	5
4	R:R:H63	6.362	5	2	6
5	R:R:D69	7.72	4	0	9
6	R:R:F70	5.7375	4	5	7
7	R:R:V76	7.01	4	1	7
8	R:R:M77	5.55	5	0	7
9	R:R:M81	5.1975	4	0	6
10	R:R:W89	10.5383	6	3	7
11	R:R:D103	9.725	4	1	6
12	R:R:H113	8.552	5	2	8
13	R:R:I117	4.814	5	8	9
14	R:R:Y131	5.864	5	4	7
15	R:R:M135	5.012	5	4	7
16	R:R:W148	5.446	5	2	9
17	R:R:F154	7.0075	4	0	4
18	R:R:F160	5.5275	4	9	4
19	R:R:F165	14.6275	4	0	4
20	R:R:F185	8.294	5	0	1
21	R:R:F186	5.268	5	0	1
22	R:R:F195	7.628	5	1	5
23	R:R:F199	8.564	5	1	8
24	R:R:Y210	5.196	5	0	9
25	R:R:Y214	4.1925	4	0	5
26	R:R:F260	7.2675	4	1	9
27	R:R:W264	7.99375	8	1	8
28	R:R:F267	6.62833	6	1	5
29	R:R:F268	7.87	5	1	7
30	R:R:I281	4.385	4	0	2
31	R:R:L289	3.91	4	0	5
32	R:R:W291	8.91	4	0	4
33	R:R:Y294	9.19667	6	1	7
34	R:R:N300	8.1975	4	0	9
35	R:R:Y304	5.008	5	8	9
36	R:R:Y308	7.78	4	0	8
37	R:R:F311	5.91333	6	6	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y294	50.0566	17.5	Yes	Yes	1	0	7
2	R:R:W291	R:R:Y294	27.6641	9.65	Yes	Yes	0	4	7
3	R:R:M30	R:R:W291	16.9794	16.29	No	Yes	0	6	4
4	R:R:M77	R:R:Y294	18.6788	7.18	Yes	Yes	0	7	7
5	R:R:I34	R:R:M77	11.5662	4.37	No	Yes	0	6	7
6	R:R:I34	R:R:M81	10.582	4.37	No	Yes	0	6	6
7	R:R:M81	R:R:Y27	14.8375	4.79	Yes	Yes	0	6	6
8	R:R:M30	R:R:M81	10.9679	10.11	No	Yes	0	6	6
9	L:L:?1	R:R:W264	79.1475	12.14	Yes	Yes	1	0	8
10	R:R:N296	R:R:W264	100	14.69	No	Yes	0	9	8
11	R:R:N296	R:R:N300	99.4973	12.26	No	Yes	0	9	9
12	R:R:D69	R:R:N300	18.4947	8.08	Yes	Yes	0	9	9
13	R:R:D69	R:R:N41	10.5325	8.08	Yes	No	0	9	9
14	R:R:M65	R:R:N300	96.3358	4.21	No	Yes	0	9	9
15	R:R:I117	R:R:M65	52.542	4.37	Yes	No	0	9	9
16	R:R:I117	R:R:I62	49.561	2.94	Yes	No	0	9	8
17	R:R:I48	R:R:I62	48.7786	2.94	No	No	0	7	8
18	R:R:F311	R:R:I48	11.7503	3.77	Yes	No	0	9	7
19	R:R:H113	R:R:M65	48.8777	7.88	Yes	No	0	8	9
20	R:R:H113	R:R:W148	37.5345	4.23	Yes	Yes	2	8	9
21	R:R:T67	R:R:W148	36.7698	6.06	No	Yes	2	6	9
22	R:R:H63	R:R:T67	35.2687	4.11	Yes	No	2	6	6
23	R:R:H63	R:R:I48	40.4836	9.28	Yes	No	0	6	7
24	R:R:H63	R:R:W60	70.7675	6.35	Yes	No	0	6	4
25	R:R:I137	R:R:W60	65.6907	4.7	No	No	0	2	4
26	R:R:I137	R:R:P57	62.2708	5.08	No	No	0	2	6
27	R:R:P57	R:R:T56	19.0222	3.5	No	No	0	6	8
28	R:R:N59	R:R:T56	17.1316	8.77	No	No	0	9	8
29	R:R:L54	R:R:N59	15.234	4.12	No	No	0	8	9
30	R:R:F51	R:R:L54	11.3963	6.09	Yes	No	7	5	8
31	R:R:I140	R:R:P57	43.153	6.77	No	No	0	7	6
32	R:R:I140	R:R:M135	41.3545	2.92	No	Yes	0	7	7
33	R:R:L72	R:R:V76	11.106	4.47	No	Yes	0	7	7
34	R:R:L72	R:R:S297	10.0439	4.5	No	No	0	7	9
35	R:R:H99	R:R:V76	15.0747	8.3	No	Yes	0	5	7
36	L:L:?1	R:R:F267	50.2089	10.39	Yes	Yes	1	0	5
37	R:R:F267	R:R:L289	83.0985	3.65	Yes	Yes	0	5	5
38	R:R:L285	R:R:L289	78.2553	5.54	No	Yes	0	4	5
39	R:R:I281	R:R:L285	76.6268	4.28	Yes	No	0	2	4
40	R:R:D274	R:R:I281	68.3778	8.4	No	Yes	0	2	2
41	R:R:D274	R:R:Y279	66.7068	5.75	No	No	0	2	1
42	R:R:F185	R:R:Y279	54.8113	9.28	Yes	No	0	1	1
43	R:R:F185	R:R:H175	11.4884	10.18	Yes	No	0	1	3
44	R:R:F185	R:R:Y172	39.0073	15.47	Yes	No	0	1	3
45	R:R:F165	R:R:Y172	35.4174	36.1	Yes	No	0	4	3
46	R:R:E162	R:R:F165	14.9827	12.83	No	Yes	0	5	4
47	R:R:E162	R:R:K97	13.1169	8.1	No	No	0	5	6
48	R:R:F160	R:R:K97	11.2582	7.44	Yes	No	0	4	6
49	R:R:F165	R:R:N164	13.1948	7.25	Yes	No	0	4	4
50	R:R:I159	R:R:N164	11.3361	4.25	No	No	0	6	4
51	R:R:H113	R:R:S147	10.6068	15.34	Yes	No	0	8	7
52	R:R:L114	R:R:N300	11.0458	8.24	No	Yes	0	9	9
53	R:R:L114	R:R:Y304	10.5218	5.86	No	Yes	0	9	9
54	R:R:M135	R:R:V139	13.5276	3.04	Yes	No	0	7	5
55	R:R:F260	R:R:W264	21.0685	7.02	Yes	Yes	1	9	8
56	R:R:F260	R:R:M206	24.4035	13.68	Yes	No	0	9	9
57	R:R:M206	R:R:S118	23.6777	4.6	No	No	0	9	8
58	R:R:S118	R:R:Y210	18.8912	5.09	No	Yes	0	8	9
59	R:R:R121	R:R:Y308	15.2553	11.32	No	Yes	0	9	8
60	R:R:S118	R:R:V209	10.0085	3.23	No	No	0	8	7
61	R:R:M135	R:R:Y123	15.4323	5.99	Yes	No	0	7	4
62	L:L:?1	R:R:V184	20.5091	4.24	Yes	No	0	0	4
63	R:R:F186	R:R:V184	19.4541	5.24	Yes	No	0	1	4
64	R:R:P275	R:R:Y279	11.4884	4.17	No	No	0	4	1
65	R:R:L253	R:R:Y210	14.1401	4.69	No	Yes	0	7	9
66	R:R:L253	R:R:Y214	11.3503	1.17	No	Yes	0	7	5
67	R:R:F268	R:R:W264	34.8368	5.01	Yes	Yes	1	7	8
68	R:R:F267	R:R:F268	37.5168	5.36	Yes	Yes	1	5	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D103	17.36	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:I104	8.12	1	Yes	No	0	4	0	1
L:L:?1	R:R:S107	11.74	1	Yes	No	0	6	0	1
L:L:?1	R:R:V184	4.24	1	Yes	No	0	4	0	1
L:L:?1	R:R:S198	4.27	1	Yes	No	0	6	0	1
L:L:?1	R:R:W264	12.14	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F267	10.39	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:F268	4.33	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:I290	8.12	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y294	17.5	1	Yes	Yes	0	7	0	1
R:R:D103	R:R:V76	10.22	1	Yes	Yes	6	7	1	2
R:R:V76	R:R:Y294	5.05	1	Yes	Yes	7	7	2	1
R:R:M77	R:R:Y294	7.18	0	Yes	Yes	7	7	2	1
R:R:S80	R:R:Y294	8.9	0	No	Yes	6	7	2	1
R:R:D103	R:R:S107	4.42	1	Yes	No	6	6	1	1
R:R:D103	R:R:Y294	6.9	1	Yes	Yes	6	7	1	1
R:R:S107	R:R:W264	3.71	1	No	Yes	6	8	1	1
R:R:S108	R:R:S198	6.52	0	No	No	5	6	2	1
R:R:I111	R:R:W264	11.74	0	No	Yes	8	8	2	1
R:R:F186	R:R:V184	5.24	0	Yes	No	1	4	2	1
R:R:F195	R:R:F199	8.57	1	Yes	Yes	5	8	2	2
R:R:F195	R:R:F268	5.36	1	Yes	Yes	5	7	2	1
R:R:F199	R:R:F260	5.36	1	Yes	Yes	8	9	2	2
R:R:F199	R:R:W264	4.01	1	Yes	Yes	8	8	2	1
R:R:F199	R:R:F268	19.29	1	Yes	Yes	8	7	2	1
R:R:F260	R:R:W264	7.02	1	Yes	Yes	9	8	2	1
R:R:F268	R:R:W264	5.01	1	Yes	Yes	7	8	1	1
R:R:G293	R:R:W264	5.63	0	No	Yes	7	8	2	1
R:R:N296	R:R:W264	14.69	0	No	Yes	9	8	2	1
R:R:F267	R:R:F268	5.36	1	Yes	Yes	5	7	1	1
R:R:F267	R:R:T271	11.67	1	Yes	No	5	5	1	2
R:R:F267	R:R:L289	3.65	1	Yes	Yes	5	5	1	2
R:R:F267	R:R:I290	6.28	1	Yes	No	5	5	1	1
R:R:W291	R:R:Y294	9.65	0	Yes	Yes	4	7	2	1
R:R:A155	R:R:I104	3.25	0	No	No	6	4	2	1
R:R:F267	R:R:N286	2.42	1	Yes	No	5	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8W8A_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.65
Number of Linked Nodes	265
Number of Links	295
Number of Hubs	37
Number of Links mediated by Hubs	158
Number of Communities	10
Number of Nodes involved in Communities	49
Number of Links involved in Communities	64

Path Summary
Number Of Nodes in MetaPath	69
Number Of Links MetaPath	68
Number of Shortest Paths	59319
Length Of Smallest Path	3
Average Path Length	14.99
Length of Longest Path	35
Minimum Path Strength	1.25
Average Path Strength	7.36682
Maximum Path Strength	25.785
Minimum Path Correlation	0.7
Average Path Correlation	0.935249
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.33333
Average % Of Corr. Nodes	49.3686
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.3038
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • D1 dopamine receptor binding • dopamine receptor binding • G protein activity • molecular function regulator activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • regulation of biological process • cell population proliferation • regulation of cellular process • positive regulation of cell population proliferation • biological regulation • positive regulation of biological process • positive regulation of neural precursor cell proliferation • regulation of cell population proliferation • cellular process • neural precursor cell proliferation • positive regulation of cellular process • regulation of neural precursor cell proliferation • reactive oxygen species metabolic process • regulation of superoxide metabolic process
Gene Ontology	Biological Process	• regulation of biological process • cell population proliferation • regulation of cellular process • positive regulation of cell population proliferation • biological regulation • positive regulation of biological process • positive regulation of neural precursor cell proliferation • regulation of cell population proliferation • cellular process • neural precursor cell proliferation • positive regulation of cellular process • regulation of neural precursor cell proliferation • reactive oxygen species metabolic process • regulation of superoxide metabolic process • positive regulation of reactive oxygen species metabolic process • superoxide metabolic process • positive regulation of metabolic process • superoxide anion generation • metabolic process • positive regulation of superoxide anion generation • regulation of superoxide anion generation • regulation of metabolic process • regulation of reactive oxygen species metabolic process • regulation of calcium ion transport • regulation of localization • transport • regulation of transport • regulation of monoatomic ion transport • establishment of localization • metal ion transport • calcium ion transport • localization • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • cellular response to stimulus • positive regulation of cell communication • positive regulation of signal transduction • response to stimulus • signaling • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • signal transduction • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • negative regulation of signaling • negative regulation of biological process • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • adenylate cyclase-activating adrenergic receptor signaling pathway • negative regulation of response to stimulus • adenylate cyclase-activating G protein-coupled receptor signaling pathway • negative regulation of signal transduction • negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell division • regulation of body fluid levels • multicellular organismal process • renal system process • system process • positive regulation of urine volume • regulation of urine volume • regulation of biological quality • regulation of vascular associated smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell proliferation • regulation of smooth muscle cell proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • muscle cell proliferation • vascular associated smooth muscle cell proliferation • cell-cell signaling • gamma-aminobutyric acid signaling pathway • purinergic nucleotide receptor signaling pathway • cell surface receptor signaling pathway • G protein-coupled purinergic receptor signaling pathway • G protein-coupled adenosine receptor signaling pathway • regulation of molecular function • regulation of adenylate cyclase activity • regulation of catalytic activity • negative regulation of molecular function • negative regulation of catalytic activity • negative regulation of adenylate cyclase activity • regulated exocytosis • regulation of calcium ion-dependent exocytosis • negative regulation of transport • negative regulation of regulated secretory pathway • vesicle-mediated transport • regulation of regulated secretory pathway • secretion by cell • regulation of secretion by cell • negative regulation of secretion • negative regulation of exocytosis • negative regulation of secretion by cell • calcium-ion regulated exocytosis • secretion • negative regulation of calcium ion-dependent exocytosis • export from cell • regulation of vesicle-mediated transport • regulation of secretion • exocytosis • regulation of exocytosis • regulation of programmed cell death • negative regulation of apoptotic signaling pathway • negative regulation of programmed cell death • regulation of apoptotic process • cell death • apoptotic signaling pathway • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of apoptotic signaling pathway • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • locomotion • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • trans-synaptic signaling • modulation of chemical synaptic transmission • negative regulation of synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • cellular response to nitrogen compound • cellular response to acetylcholine • response to oxygen-containing compound • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to chemical • response to acetylcholine • response to nutrient levels • response to nutrient • developmental process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • cellular response to endogenous stimulus • response to hormone • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of multicellular organismal process • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • hormone secretion • protein localization to extracellular region • peptide secretion • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • regulation of protein transport • protein secretion • regulation of protein secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • midbody • cellular anatomical structure • membrane • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • neuronal dense core vesicle • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • cytosol • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • neuron to neuron synapse • synapse • cell junction • hippocampal mossy fiber to CA3 synapse • cell body • cilium • ciliary basal body • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation • G protein-coupled amine receptor activity • molecular transducer activity • trace-amine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • endoplasmic reticulum subcompartment • nuclear outer membrane-endoplasmic reticulum membrane network • endoplasmic reticulum • endoplasmic reticulum membrane
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	T5U
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	T5U
Name	(4S)-4-[(2S)-2-phenylbutyl]-1,3-oxazolidin-2-imine
Synonyms	RO5256390
Identifier
Formula	C13 H18 N2 O
Molecular Weight	218.295
SMILES
PubChem	24963286
Formal Charge	0
Total Atoms	34
Total Chiral Atoms	2
Total Bonds	35
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q96RJ0
Sequence	>8W8A_nogp_Chain_R S N D V R A S L Y S L M V L I I L T T L V G N L I V I V S I S H F K Q L H T P T N W L I H S M A T V D F L L G C L V M P Y S M V R S A E H C W Y F G E V F C K I H T S T D I M L S S A S I F H L S F I S I D R Y Y A V C D P L R Y K A K M N I L V I C V M I F I S W S V P A V F A F G M I F L E L N F K G A E E I Y Y K H V H C R G G C S V F F S K I S G V L T F M T S F Y I P G S I M L C V Y Y R I Y L I A K E Q A R L I S D A N Q K L Q E R K A V K T L G I V M G V F L I C W C P F F I C T V M D P F L H Y I I P P T L N D V L I W F G Y L N S T F N P M V Y A F F Y P W F R K A L K M M Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8WC3	A	Amine	Trace Amine Receptors	TA1	Mus musculus	SEP-363856	-	chim(NtGi1-Gs)/β1/γ2	3	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC3 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	SEP-363856	-		3	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC4	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8651	-	chim(NtGi1-Gs)/β1/γ2	3.1	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC4 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8651	-		3.1	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC5	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Tetramethylammonium Ion	-	chim(NtGi1-Gs)/β1/γ2	3.3	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC5 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Tetramethylammonium Ion	-		3.3	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC6	A	Amine	Trace Amine Receptors	TA1	Mus musculus	2-Phenylethylamine	-	chim(NtGi1-Gs)/β1/γ2	3.2	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC6 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	2-Phenylethylamine	-		3.2	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC7	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8667	-	chim(NtGi1-Gs)/β1/γ2	3.1	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC7 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8667	-		3.1	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC8	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	ZH8651	-	chim(NtGi1-Gs)/β1/γ2	2.9	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC8 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	ZH8651	-		2.9	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC9	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8651	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.2	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC9 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8651	-		3.2	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WCA	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	2-Phenylethylamine	-	chim(NtGi1-Gs)/β1/γ2	3.48	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WCA (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	2-Phenylethylamine	-		3.48	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WCB	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Cyclohexylammonium Ion	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WCB (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Cyclohexylammonium Ion	-		3.1	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WCC	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Cyclohexylammonium Ion	-	-	3.04	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8ZSJ	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	-	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-07-24	doi.org/10.1016/j.celrep.2024.114505
	8ZSJ (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	-	-		2.8	2024-07-24	doi.org/10.1016/j.celrep.2024.114505
	8ZSP	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	LSD	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.14	2024-07-24	doi.org/10.1016/j.celrep.2024.114505
	8ZSP (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	LSD	-		3.14	2024-07-24	doi.org/10.1016/j.celrep.2024.114505
	8ZSS	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5263397	-	chim(NtGi1-Gs)/β1/γ2	3.07	2024-07-24	doi.org/10.1016/j.celrep.2024.114505
	8ZSS (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5263397	-		3.07	2024-07-24	doi.org/10.1016/j.celrep.2024.114505
	8ZSV	A	Amine	Trace Amine Receptors	TA1	Mus musculus	RO5263397	-	chim(NtGi1-Gs)/β1/γ2	2.96	2024-07-24	doi.org/10.1016/j.celrep.2024.114505
	8ZSV (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	RO5263397	-		2.96	2024-07-24	doi.org/10.1016/j.celrep.2024.114505
	8UHB	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5256390	-	Gs/β1/γ2	3.35	2024-01-10	doi.org/10.1038/s41467-023-44601-4
	8UHB (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5256390	-		3.35	2024-01-10	doi.org/10.1038/s41467-023-44601-4
	8W87	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	METH	-	chim(NtGi1L-Gs)/β1/γ2	2.8	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W87 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	METH	-		2.8	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W88	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	SEP-363856	-	Gs/β1/γ2	2.6	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W88 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	SEP-363856	-		2.6	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W89	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	PEA	-	chim(NtGi1L-Gs)/β1/γ2	3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W89 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	PEA	-		3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W8A	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5256390	-	chim(NtGi1L-Gs)/β1/γ2	2.8	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W8A (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5256390	-		2.8	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8JLJ	A	Amine	Trace Amine Receptors	TA1	Mus musculus	T1AM	-	chim(NtGi1-Gs)/β1/γ2	3.1	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLJ (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	T1AM	-		3.1	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLK	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Ulotaront	-	chim(NtGi1-Gs)/β1/γ2	3.22	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLK (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Ulotaront	-		3.22	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLN	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	T1AM	-	Gs/β1/γ2	3.24	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLN (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	T1AM	-		3.24	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLO	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Ulotaront	-	Gs/β1/γ2	3.52	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLO (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Ulotaront	-		3.52	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLP	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Ralmitaront	-	Gs/β1/γ2	3.23	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLP (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Ralmitaront	-		3.23	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLQ	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Fenoldopam	-	Gs/β1/γ2	2.84	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLQ (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Fenoldopam	-		2.84	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLR	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	A77636	-	chim(NtGi1-Gs)/β1/γ2	3	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLR (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	A77636	-		3	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JSO	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	AMPH	-	chim(NtGi1-Gs)/β1/γ2	3.4	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JSO (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	AMPH	-		3.4	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	9JKQ	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	METH	-	Gs/β1/γ2	2.66	2024-10-16	doi.org/10.1021/acs.jmedchem.4c01961
	9JKQ (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	METH	-		2.66	2024-10-16	doi.org/10.1021/acs.jmedchem.4c01961

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