psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D103	14.3	Yes	Yes	1	0	6
2	L:L:?1	R:R:I104	8.1	Yes	No	0	0	4
3	L:L:?1	R:R:S107	8.52	Yes	No	1	0	6
4	L:L:?1	R:R:S108	12.17	Yes	No	0	0	5
5	L:L:?1	R:R:F112	4.94	Yes	No	0	0	6
6	L:L:?1	R:R:F154	10.86	Yes	No	0	0	4
7	L:L:?1	R:R:F186	3.95	Yes	Yes	1	0	1
8	L:L:?1	R:R:T194	11.95	Yes	No	1	0	5
9	L:L:?1	R:R:S198	10.95	Yes	No	1	0	6
10	L:L:?1	R:R:F267	9.87	Yes	Yes	1	0	5
11	L:L:?1	R:R:F268	2.96	Yes	Yes	1	0	7
12	L:L:?1	R:R:I290	5.78	Yes	No	0	0	5
13	R:R:S19	R:R:V22	3.23	No	No	0	2	3
14	R:R:R23	R:R:V22	6.54	No	No	0	4	3
15	R:R:S25	R:R:V22	3.23	No	No	0	4	3
16	R:R:L26	R:R:R23	3.64	No	No	0	5	4
17	R:R:V82	R:R:Y27	5.05	No	No	0	5	6
18	R:R:A85	R:R:Y27	5.34	No	No	0	5	6
19	R:R:I33	R:R:L29	2.85	No	No	0	7	5
20	R:R:M30	R:R:M81	4.33	No	Yes	0	6	6
21	R:R:M30	R:R:S84	3.07	No	No	0	6	5
22	R:R:M30	R:R:W291	15.12	No	No	0	6	4
23	R:R:L32	R:R:T36	2.95	No	No	0	5	5
24	R:R:I33	R:R:L295	2.85	No	No	0	7	5
25	R:R:I34	R:R:L38	2.85	No	No	0	6	6
26	R:R:I34	R:R:M77	2.92	No	Yes	0	6	7
27	R:R:I34	R:R:M81	2.92	No	Yes	0	6	6
28	R:R:T298	R:R:T36	3.14	No	No	0	7	5
29	R:R:N41	R:R:T37	4.39	Yes	No	0	9	7
30	R:R:T298	R:R:T37	9.42	No	No	0	7	7
31	R:R:F70	R:R:L38	4.87	No	No	0	7	6
32	R:R:I43	R:R:V39	3.07	No	No	0	7	5
33	R:R:D69	R:R:N41	6.73	No	Yes	0	9	9
34	R:R:F70	R:R:N41	3.62	No	Yes	0	7	9
35	R:R:N41	R:R:P301	6.52	Yes	No	0	9	9
36	R:R:L42	R:R:V46	2.98	No	No	0	4	4
37	R:R:F70	R:R:L42	4.87	No	No	0	7	4
38	R:R:I43	R:R:L315	2.85	No	No	0	7	7
39	R:R:A66	R:R:V44	3.39	No	No	0	9	9
40	R:R:A305	R:R:V44	3.39	No	No	0	7	9
41	R:R:H63	R:R:I45	5.3	Yes	No	5	6	8
42	R:R:A66	R:R:I45	3.25	No	No	0	9	8
43	R:R:I45	R:R:T67	3.04	No	No	5	8	6
44	R:R:F311	R:R:S47	5.28	No	No	0	9	8
45	R:R:I48	R:R:L54	4.28	Yes	No	0	7	8
46	R:R:F311	R:R:I48	3.77	No	Yes	0	9	7
47	R:R:H50	R:R:M318	3.94	No	No	0	5	6
48	R:R:F51	R:R:Q53	14.05	No	No	0	5	5
49	R:R:F51	R:R:L54	6.09	No	No	0	5	8
50	R:R:F51	R:R:M318	8.71	No	No	0	5	6
51	R:R:H55	R:R:W60	8.46	No	No	0	8	4
52	R:R:P57	R:R:T56	3.5	No	No	0	6	8
53	R:R:T56	R:R:T58	3.14	No	No	0	8	8
54	R:R:N59	R:R:T56	4.39	No	No	0	9	8
55	R:R:I137	R:R:P57	3.39	No	No	0	2	6
56	R:R:I140	R:R:P57	6.77	Yes	No	0	7	6
57	R:R:D120	R:R:T58	5.78	No	No	0	9	8
58	R:R:N59	R:R:W310	4.52	No	No	0	9	6
59	R:R:H63	R:R:W60	4.23	Yes	No	0	6	4
60	R:R:I140	R:R:L61	4.28	Yes	No	0	7	7
61	R:R:I117	R:R:I62	2.94	No	No	2	9	8
62	R:R:I62	R:R:Y304	3.63	No	Yes	2	8	9
63	R:R:H63	R:R:T67	6.85	Yes	No	5	6	6
64	R:R:I144	R:R:S64	6.19	No	No	0	7	9
65	R:R:L114	R:R:M65	7.07	No	No	2	9	9
66	R:R:I117	R:R:M65	4.37	No	No	2	9	9
67	R:R:M65	R:R:N300	8.41	No	No	2	9	9
68	R:R:L106	R:R:V68	2.98	No	No	0	6	8
69	R:R:V68	R:R:W148	4.9	No	No	0	8	9
70	R:R:D69	R:R:S110	5.89	No	No	0	9	9
71	R:R:D69	R:R:N300	6.73	No	No	0	9	9
72	R:R:L106	R:R:L72	6.92	No	No	0	6	7
73	R:R:L72	R:R:S297	4.5	No	No	0	7	9
74	R:R:G73	R:R:M77	5.24	No	Yes	0	7	7
75	R:R:C74	R:R:L75	4.76	No	No	0	4	5
76	R:R:T102	R:R:V76	3.17	No	No	0	4	7
77	R:R:D103	R:R:V76	4.38	Yes	No	0	6	7
78	R:R:M77	R:R:W291	3.49	Yes	No	1	7	4
79	R:R:M77	R:R:Y294	5.99	Yes	Yes	1	7	7
80	R:R:P78	R:R:Y79	5.56	No	Yes	0	8	5
81	R:R:F91	R:R:Y79	4.13	Yes	Yes	4	6	5
82	R:R:F95	R:R:Y79	8.25	No	Yes	4	5	5
83	R:R:H99	R:R:Y79	5.44	No	Yes	0	5	5
84	R:R:R83	R:R:S80	5.27	No	No	0	4	6
85	R:R:H99	R:R:S80	5.58	No	No	0	5	6
86	R:R:R83	R:R:W89	5	No	Yes	0	4	7
87	R:R:R179	R:R:R83	7.46	Yes	No	0	2	4
88	R:R:D287	R:R:S84	4.42	No	No	0	3	5
89	R:R:C88	R:R:E86	3.04	No	No	0	4	4
90	R:R:E86	R:R:Y90	19.08	No	No	0	4	1
91	R:R:F91	R:R:W89	5.01	Yes	Yes	4	6	7
92	R:R:C96	R:R:W89	7.84	No	Yes	4	9	7
93	R:R:C182	R:R:W89	9.14	No	Yes	4	9	7
94	R:R:F91	R:R:Y90	3.09	Yes	No	0	6	1
95	R:R:F91	R:R:F95	9.65	Yes	No	4	6	5
96	R:R:E93	R:R:V94	4.28	No	No	0	2	1
97	R:R:C182	R:R:C96	7.28	No	No	4	9	9
98	R:R:I159	R:R:K97	2.91	Yes	No	0	6	6
99	R:R:F160	R:R:K97	4.96	No	No	0	4	6
100	R:R:I159	R:R:T100	4.56	Yes	No	0	6	4
101	R:R:T100	R:R:V184	3.17	No	No	0	4	4
102	R:R:F156	R:R:S101	7.93	Yes	No	0	4	6
103	R:R:I159	R:R:S101	9.29	Yes	No	0	6	6
104	R:R:L106	R:R:T102	2.95	No	No	0	6	4
105	R:R:D103	R:R:S107	2.94	Yes	No	1	6	6
106	R:R:D103	R:R:Y294	8.05	Yes	Yes	1	6	7
107	R:R:A155	R:R:I104	3.25	No	No	0	6	4
108	R:R:I104	R:R:I159	2.94	No	Yes	0	4	6
109	R:R:A152	R:R:M105	4.83	No	No	0	3	5
110	R:R:S107	R:R:W264	3.71	No	Yes	1	6	8
111	R:R:P151	R:R:S108	3.56	No	No	0	8	5
112	R:R:A109	R:R:H113	2.93	No	Yes	0	7	8
113	R:R:I111	R:R:P202	3.39	No	Yes	0	8	9
114	R:R:I111	R:R:W264	7.05	No	Yes	0	8	8
115	R:R:H113	R:R:S147	13.95	Yes	No	0	8	7
116	R:R:H113	R:R:W148	4.23	Yes	No	0	8	9
117	R:R:L114	R:R:N300	8.24	No	No	2	9	9
118	R:R:L114	R:R:Y304	8.21	No	Yes	2	9	9
119	R:R:F116	R:R:M143	12.44	No	No	0	7	6
120	R:R:I117	R:R:Y304	6.04	No	Yes	2	9	9
121	R:R:M206	R:R:S118	3.07	Yes	Yes	1	9	8
122	R:R:S118	R:R:Y210	3.82	Yes	Yes	1	8	9
123	R:R:I119	R:R:I205	2.94	No	Yes	1	6	6
124	R:R:D120	R:R:Y131	6.9	No	Yes	6	9	7
125	R:R:D120	R:R:M135	4.16	No	Yes	6	9	7
126	R:R:R121	R:R:Y308	7.2	No	Yes	0	9	8
127	R:R:C126	R:R:Y122	14.79	No	No	0	6	8
128	R:R:V209	R:R:Y122	8.83	No	No	0	7	8
129	R:R:M135	R:R:Y123	5.99	Yes	No	0	7	4
130	R:R:A124	R:R:Y131	6.67	No	Yes	0	8	7
131	R:R:D127	R:R:P128	3.22	No	No	0	5	8
132	R:R:D127	R:R:R130	4.76	No	No	0	5	5
133	R:R:L129	R:R:P128	3.28	No	No	0	7	8
134	R:R:M135	R:R:Y131	5.99	Yes	Yes	6	7	7
135	R:R:K134	R:R:M135	2.88	No	Yes	0	4	7
136	R:R:M135	R:R:M143	2.89	Yes	No	0	7	6
137	R:R:N136	R:R:V139	2.96	No	No	0	8	5
138	R:R:I140	R:R:V139	3.07	Yes	No	0	7	5
139	R:R:I140	R:R:M143	2.92	Yes	No	0	7	6
140	R:R:I140	R:R:I144	2.94	Yes	No	0	7	7
141	R:R:I146	R:R:V142	3.07	No	No	0	3	3
142	R:R:F145	R:R:S149	10.57	No	No	0	5	4
143	R:R:P151	R:R:V150	3.53	No	No	0	8	4
144	R:R:F154	R:R:M158	9.95	No	Yes	0	4	5
145	R:R:F156	R:R:F160	7.5	Yes	No	0	4	4
146	R:R:I159	R:R:M158	2.92	Yes	Yes	0	6	5
147	R:R:M158	R:R:N164	4.21	Yes	No	0	5	4
148	R:R:E162	R:R:F165	5.83	No	No	0	5	4
149	R:R:F165	R:R:N164	13.29	No	No	0	4	4
150	R:R:F165	R:R:Y172	17.54	No	Yes	0	4	3
151	R:R:I189	R:R:K166	4.36	No	No	0	4	3
152	R:R:E169	R:R:G167	4.91	No	No	0	4	4
153	R:R:A168	R:R:I171	3.25	No	Yes	0	3	2
154	R:R:E169	R:R:Y173	5.61	No	No	0	4	2
155	R:R:I171	R:R:K174	7.27	Yes	No	0	2	4
156	R:R:F185	R:R:I171	3.77	Yes	Yes	3	1	2
157	R:R:I171	R:R:Y279	7.25	Yes	Yes	3	2	1
158	R:R:Y172	R:R:Y173	5.96	Yes	No	0	3	2
159	R:R:V176	R:R:Y172	6.31	No	Yes	0	3	3
160	R:R:F185	R:R:Y172	11.35	Yes	Yes	0	1	3
161	R:R:F185	R:R:H175	9.05	Yes	No	0	1	3
162	R:R:S183	R:R:V176	4.85	No	No	0	4	3
163	R:R:R179	R:R:S183	10.54	Yes	No	0	2	4
164	R:R:N286	R:R:R179	3.62	No	Yes	0	4	2
165	R:R:D287	R:R:R179	5.96	No	Yes	0	3	2
166	R:R:I290	R:R:R179	3.76	No	Yes	0	5	2
167	R:R:F186	R:R:V184	3.93	Yes	No	0	1	4
168	R:R:F185	R:R:Y279	6.19	Yes	Yes	3	1	1
169	R:R:F186	R:R:G191	3.01	Yes	No	1	1	4
170	R:R:F186	R:R:T194	7.78	Yes	No	1	1	5
171	R:R:S187	R:R:S190	6.52	No	No	0	4	6
172	R:R:F276	R:R:K188	8.69	No	No	0	5	3
173	R:R:I189	R:R:L193	7.14	No	No	0	4	3
174	R:R:G191	R:R:S190	3.71	No	No	0	4	6
175	R:R:G191	R:R:T194	3.64	No	No	1	4	5
176	R:R:F195	R:R:M196	4.98	No	No	0	5	5
177	R:R:F195	R:R:F268	3.22	No	Yes	0	5	7
178	R:R:F195	R:R:V272	13.11	No	No	0	5	6
179	R:R:M196	R:R:Y200	3.59	No	No	0	5	5
180	R:R:F268	R:R:S198	5.28	Yes	No	1	7	6
181	R:R:F199	R:R:F260	7.5	Yes	Yes	1	8	9
182	R:R:F199	R:R:W264	4.01	Yes	Yes	1	8	8
183	R:R:C265	R:R:F199	4.19	No	Yes	0	6	8
184	R:R:F199	R:R:F268	13.93	Yes	Yes	1	8	7
185	R:R:I201	R:R:P202	3.39	No	Yes	0	6	9
186	R:R:M206	R:R:Y210	3.59	Yes	Yes	1	9	9
187	R:R:M206	R:R:M257	5.78	Yes	No	1	9	8
188	R:R:F260	R:R:M206	4.98	Yes	Yes	1	9	9
189	R:R:L207	R:R:M257	5.65	No	No	0	5	8
190	R:R:L253	R:R:Y210	8.21	No	Yes	0	7	9
191	R:R:M257	R:R:Y210	4.79	No	Yes	1	8	9
192	R:R:L215	R:R:Y211	8.21	No	No	0	4	3
193	R:R:V250	R:R:Y214	5.05	No	Yes	0	8	5
194	R:R:L253	R:R:Y214	3.52	No	Yes	0	7	5
195	R:R:E246	R:R:K218	5.4	No	No	0	7	6
196	R:R:L223	R:R:R222	4.86	No	No	0	4	4
197	R:R:F307	R:R:T252	5.19	No	No	0	7	9
198	R:R:V256	R:R:V303	3.21	No	Yes	0	8	8
199	R:R:V259	R:R:V303	4.81	No	Yes	2	6	8
200	R:R:F260	R:R:W264	4.01	Yes	Yes	1	9	8
201	R:R:C263	R:R:N296	9.45	No	No	0	8	9
202	R:R:F268	R:R:W264	3.01	Yes	Yes	1	7	8
203	R:R:N296	R:R:W264	14.69	No	Yes	0	9	8
204	R:R:C265	R:R:I269	3.27	No	No	0	6	6
205	R:R:F267	R:R:F268	3.22	Yes	Yes	1	5	7
206	R:R:F267	R:R:T271	3.89	Yes	No	0	5	5
207	R:R:F267	R:R:L289	8.53	Yes	No	0	5	5
208	R:R:C270	R:R:L289	3.17	No	No	0	4	5
209	R:R:D274	R:R:P275	4.83	No	No	3	2	4
210	R:R:D274	R:R:Y279	4.6	No	Yes	3	2	1
211	R:R:D274	R:R:I281	8.4	No	No	3	2	2
212	R:R:P275	R:R:Y279	5.56	No	Yes	3	4	1
213	R:R:I281	R:R:P282	5.08	No	No	3	2	1
214	R:R:I281	R:R:L285	4.28	No	No	3	2	4
215	R:R:L285	R:R:P282	6.57	No	No	3	4	1
216	R:R:F292	R:R:V288	6.55	No	No	0	7	4
217	R:R:I290	R:R:Y294	6.04	No	Yes	0	5	7
218	R:R:W291	R:R:Y294	14.47	No	Yes	1	4	7
219	R:R:F306	R:R:M302	7.46	No	No	0	6	6
220	R:R:V303	R:R:Y304	5.05	Yes	Yes	2	8	9
221	R:R:F306	R:R:F311	5.36	No	No	0	6	9
222	R:R:F307	R:R:Y308	7.22	No	Yes	0	7	8
223	R:R:W310	R:R:Y308	13.5	No	Yes	0	6	8
224	R:R:I48	R:R:N59	2.83	Yes	No	0	7	9
225	R:R:L163	R:R:M158	2.83	No	Yes	0	6	5
226	R:R:K166	R:R:L163	2.82	No	No	0	3	6
227	R:R:G92	R:R:W89	2.81	No	Yes	0	8	7
228	R:R:G293	R:R:W264	2.81	No	Yes	0	7	8
229	R:R:H113	R:R:S64	2.79	Yes	No	0	8	9
230	R:R:A152	R:R:F156	2.77	No	Yes	0	3	4
231	R:R:L138	R:R:N136	2.75	No	No	0	4	8
232	R:R:A249	R:R:Y214	2.67	No	Yes	0	8	5
233	R:R:H63	R:R:I48	2.65	Yes	Yes	0	6	7
234	R:R:H55	R:R:K52	2.62	No	No	0	8	6
235	R:R:V209	R:R:Y210	2.52	No	Yes	0	7	9
236	R:R:F306	R:R:I43	2.51	No	No	0	6	7
237	R:R:F95	R:R:I98	2.51	No	No	0	5	4
238	R:R:F307	R:R:K251	2.48	No	No	0	7	6
239	R:R:F260	R:R:L261	2.44	Yes	No	0	9	6
240	R:R:F292	R:R:L295	2.44	No	No	0	7	5
241	R:R:I213	R:R:Y210	2.42	No	Yes	0	9	9
242	R:R:M81	R:R:Y27	2.39	Yes	No	0	6	6
243	R:R:K132	R:R:Y131	2.39	No	Yes	0	4	7
244	R:R:K218	R:R:Y214	2.39	No	Yes	0	6	5
245	R:R:G180	R:R:G181	2.11	No	No	0	4	3
246	R:R:R212	R:R:Y122	2.06	No	No	0	5	8
247	R:R:G203	R:R:P202	2.03	No	Yes	0	6	9
248	R:R:P282	R:R:P283	1.95	No	No	0	1	1
249	R:R:C265	R:R:P266	1.88	No	No	0	6	9
250	R:R:G40	R:R:V39	1.84	No	No	0	9	5
251	R:R:G181	R:R:V176	1.84	No	No	0	3	3
252	R:R:A217	R:R:A249	1.79	No	No	0	8	8
253	R:R:P202	R:R:S115	1.78	Yes	No	0	9	7
254	R:R:G157	R:R:L161	1.71	No	No	0	6	4
255	R:R:K188	R:R:P275	1.67	No	No	0	3	4
256	R:R:E93	R:R:G92	1.64	No	No	0	2	8
257	R:R:C141	R:R:I137	1.64	No	No	0	1	2
258	R:R:S25	R:R:S28	1.63	No	No	0	4	5
259	R:R:S149	R:R:V150	1.62	No	No	0	4	4
260	R:R:C74	R:R:L38	1.59	No	No	0	4	6
261	R:R:T284	R:R:V288	1.59	No	No	0	3	4
262	R:R:A314	R:R:L54	1.58	No	No	0	7	8
263	R:R:C126	R:R:D127	1.56	No	No	0	6	5
264	R:R:I119	R:R:S115	1.55	No	No	1	6	7
265	R:R:I205	R:R:S115	1.55	Yes	No	1	6	7
266	R:R:I119	R:R:S118	1.55	No	Yes	1	6	8
267	R:R:I205	R:R:S118	1.55	Yes	Yes	1	6	8
268	R:R:I205	R:R:S204	1.55	Yes	No	0	6	4
269	R:R:I216	R:R:V125	1.54	No	No	0	5	8
270	R:R:I146	R:R:V150	1.54	No	No	0	3	4
271	R:R:A227	R:R:D226	1.54	No	No	0	4	4
272	R:R:I255	R:R:V259	1.54	No	No	2	6	6
273	R:R:I255	R:R:V303	1.54	No	Yes	2	6	8
274	R:R:M81	R:R:V31	1.52	Yes	No	0	6	5
275	R:R:I33	R:R:T298	1.52	No	No	0	7	7
276	R:R:M196	R:R:V192	1.52	No	No	0	5	5
277	R:R:M273	R:R:V272	1.52	No	No	0	4	6
278	R:R:F156	R:R:G157	1.51	Yes	No	0	4	6
279	R:R:N20	R:R:S19	1.49	No	No	0	5	2
280	R:R:L35	R:R:V31	1.49	No	No	0	5	5
281	R:R:D21	R:R:S19	1.47	No	No	0	4	2
282	R:R:L71	R:R:T67	1.47	No	No	0	7	6
283	R:R:I224	R:R:N228	1.42	No	No	0	5	4
284	R:R:P309	R:R:Y308	1.39	No	Yes	0	5	8
285	R:R:F299	R:R:V259	1.31	No	No	0	6	6
286	R:R:E219	R:R:Q220	1.27	No	No	0	3	6
287	R:R:I216	R:R:R212	1.25	No	No	0	5	5
288	R:R:F276	R:R:L277	1.22	No	No	0	5	3
289	L:L:?1	R:R:T197	1.19	Yes	No	0	0	4
290	R:R:D226	R:R:R222	1.19	No	No	0	4	4
291	R:R:L215	R:R:Y214	1.17	No	Yes	0	4	5
292	R:R:H87	R:R:R23	1.13	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.11846	13	1	0
2	R:R:N41	5.315	4	0	9
3	R:R:I48	3.3825	4	0	7
4	R:R:H63	4.7575	4	5	6
5	R:R:M77	4.41	4	1	7
6	R:R:Y79	5.845	4	4	5
7	R:R:M81	2.79	4	0	6
8	R:R:W89	5.96	5	4	7
9	R:R:F91	5.47	4	4	6
10	R:R:D103	7.4175	4	1	6
11	R:R:H113	5.975	4	0	8
12	R:R:S118	2.4975	4	1	8
13	R:R:Y131	5.4875	4	6	7
14	R:R:M135	4.382	5	6	7
15	R:R:I140	3.996	5	0	7
16	R:R:F156	4.9275	4	0	4
17	R:R:M158	4.9775	4	0	5
18	R:R:I159	4.524	5	0	6
19	R:R:I171	5.385	4	3	2
20	R:R:Y172	10.29	4	0	3
21	R:R:R179	6.268	5	0	2
22	R:R:F185	7.59	4	3	1
23	R:R:F186	4.6675	4	1	1
24	R:R:F199	7.4075	4	1	8
25	R:R:P202	2.6475	4	0	9
26	R:R:I205	1.8975	4	1	6
27	R:R:M206	4.355	4	1	9
28	R:R:Y210	4.225	6	1	9
29	R:R:Y214	2.96	5	0	5
30	R:R:F260	4.7325	4	1	9
31	R:R:W264	5.61286	7	1	8
32	R:R:F267	6.3775	4	1	5
33	R:R:F268	5.27	6	1	7
34	R:R:Y279	5.9	4	3	1
35	R:R:Y294	8.6375	4	1	7
36	R:R:V303	3.6525	4	2	8
37	R:R:Y304	5.7325	4	2	9
38	R:R:Y308	7.3275	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D103	62.7988	14.3	Yes	Yes	1	0	6
2	R:R:D103	R:R:Y294	67.4438	8.05	Yes	Yes	1	6	7
3	R:R:M77	R:R:Y294	64.094	5.99	Yes	Yes	1	7	7
4	R:R:I34	R:R:M77	61.5095	2.92	No	Yes	0	6	7
5	L:L:?1	R:R:I290	78.2056	5.78	Yes	No	0	0	5
6	R:R:I290	R:R:Y294	44.3601	6.04	No	Yes	0	5	7
7	R:R:W291	R:R:Y294	11.2799	14.47	No	Yes	1	4	7
8	R:R:M30	R:R:M81	10.2555	4.33	No	Yes	0	6	6
9	R:R:I34	R:R:L38	53.915	2.85	No	No	0	6	6
10	R:R:F70	R:R:L38	49.3583	4.87	No	No	0	7	6
11	R:R:F70	R:R:N41	44.6956	3.62	No	Yes	0	7	9
12	R:R:N41	R:R:T37	18.1856	4.39	Yes	No	0	9	7
13	R:R:T298	R:R:T37	16.4194	9.42	No	No	0	7	7
14	R:R:I33	R:R:T298	11.0503	1.52	No	No	0	7	7
15	R:R:I290	R:R:R179	87.8959	3.76	No	Yes	0	5	2
16	R:R:D103	R:R:V76	100	4.38	Yes	No	0	6	7
17	R:R:T102	R:R:V76	98.799	3.17	No	No	0	4	7
18	R:R:L106	R:R:T102	97.5863	2.95	No	No	0	6	4
19	R:R:L106	R:R:V68	93.8773	2.98	No	No	0	6	8
20	R:R:V68	R:R:W148	92.6175	4.9	No	No	0	8	9
21	R:R:H113	R:R:W148	91.3458	4.23	Yes	No	0	8	9
22	R:R:H113	R:R:S64	87.4603	2.79	Yes	No	0	8	9
23	R:R:I144	R:R:S64	86.1415	6.19	No	No	0	7	9
24	R:R:I140	R:R:I144	84.811	2.94	Yes	No	0	7	7
25	R:R:I140	R:R:P57	63.4758	6.77	Yes	No	0	7	6
26	R:R:P57	R:R:T56	59.0074	3.5	No	No	0	6	8
27	R:R:N59	R:R:T56	57.2471	4.39	No	No	0	9	8
28	R:R:I48	R:R:N59	44.6544	2.83	Yes	No	0	7	9
29	R:R:F311	R:R:I48	14.9947	3.77	No	Yes	0	9	7
30	R:R:F306	R:R:F311	11.3623	5.36	No	No	0	6	9
31	R:R:D69	R:R:N41	24.9853	6.73	No	Yes	0	9	9
32	R:R:H63	R:R:I48	18.892	2.65	Yes	Yes	0	6	7
33	R:R:I48	R:R:L54	11.2622	4.28	Yes	No	0	7	8
34	R:R:I140	R:R:M143	15.5834	2.92	Yes	No	0	7	6
35	R:R:M135	R:R:M143	11.8921	2.89	Yes	No	0	7	6
36	R:R:N59	R:R:W310	12.9577	4.52	No	No	0	9	6
37	R:R:D69	R:R:N300	21.5354	6.73	No	No	0	9	9
38	R:R:L114	R:R:N300	14.353	8.24	No	No	2	9	9
39	R:R:L114	R:R:Y304	12.6222	8.21	No	Yes	2	9	9
40	R:R:R179	R:R:R83	41.858	7.46	Yes	No	0	2	4
41	R:R:R83	R:R:W89	31.0785	5	No	Yes	0	4	7
42	R:R:F91	R:R:W89	18.0443	5.01	Yes	Yes	4	6	7
43	L:L:?1	R:R:I104	23.6371	8.1	Yes	No	0	0	4
44	R:R:I104	R:R:I159	20.0165	2.94	No	Yes	0	4	6
45	R:R:I159	R:R:S101	13.3875	9.29	Yes	No	0	6	6
46	R:R:F156	R:R:S101	11.1857	7.93	Yes	No	0	4	6
47	L:L:?1	R:R:S107	27.0988	8.52	Yes	No	1	0	6
48	R:R:S107	R:R:W264	58.0478	3.71	No	Yes	1	6	8
49	L:L:?1	R:R:F268	62.893	2.96	Yes	Yes	1	0	7
50	R:R:F268	R:R:W264	29.4066	3.01	Yes	Yes	1	7	8
51	L:L:?1	R:R:S108	16.3134	12.17	Yes	No	0	0	5
52	R:R:P151	R:R:S108	14.0174	3.56	No	No	0	8	5
53	R:R:I111	R:R:W264	16.7138	7.05	No	Yes	0	8	8
54	R:R:I111	R:R:P202	14.5414	3.39	No	Yes	0	8	9
55	R:R:F260	R:R:W264	61.38	4.01	Yes	Yes	1	9	8
56	R:R:F260	R:R:M206	77.8053	4.98	Yes	Yes	1	9	9
57	R:R:F199	R:R:F268	27.6404	13.93	Yes	Yes	1	8	7
58	R:R:F199	R:R:F260	21.659	7.5	Yes	Yes	1	8	9
59	R:R:M206	R:R:S118	11.3505	3.07	Yes	Yes	1	9	8
60	R:R:M206	R:R:Y210	58.3775	3.59	Yes	Yes	1	9	9
61	R:R:W310	R:R:Y308	11.1857	13.5	No	Yes	0	6	8
62	R:R:V209	R:R:Y210	29.3712	2.52	No	Yes	0	7	9
63	R:R:V209	R:R:Y122	26.4865	8.83	No	No	0	7	8
64	R:R:C126	R:R:Y122	14.8299	14.79	No	No	0	6	8
65	R:R:C126	R:R:D127	11.8863	1.56	No	No	0	6	5
66	R:R:P151	R:R:V150	11.7096	3.53	No	No	0	8	4
67	L:L:?1	R:R:F154	41.1986	10.86	Yes	No	0	0	4
68	R:R:F154	R:R:M158	39.5384	9.95	No	Yes	0	4	5
69	R:R:M158	R:R:N164	32.097	4.21	Yes	No	0	5	4
70	R:R:F165	R:R:N164	30.2779	13.29	No	No	0	4	4
71	R:R:F165	R:R:Y172	27.7111	17.54	No	Yes	0	4	3
72	R:R:R179	R:R:S183	48.1043	10.54	Yes	No	0	2	4
73	R:R:S183	R:R:V176	46.1203	4.85	No	No	0	4	3
74	R:R:V176	R:R:Y172	40.5746	6.31	No	Yes	0	3	3
75	R:R:Y172	R:R:Y173	10.6441	5.96	Yes	No	0	3	2
76	R:R:F185	R:R:Y172	52.1842	11.35	Yes	Yes	0	1	3
77	R:R:F185	R:R:I171	10.4674	3.77	Yes	Yes	3	1	2
78	R:R:F185	R:R:Y279	34.9052	6.19	Yes	Yes	3	1	1
79	L:L:?1	R:R:F186	12.8105	3.95	Yes	Yes	1	0	1
80	R:R:P275	R:R:Y279	14.0527	5.56	No	Yes	3	4	1
81	R:R:K188	R:R:P275	10.6441	1.67	No	No	0	3	4
82	R:R:F195	R:R:F268	12.5692	3.22	No	Yes	0	5	7
83	R:R:L253	R:R:Y210	26.2687	8.21	No	Yes	0	7	9
84	R:R:L253	R:R:Y214	23.3722	3.52	No	Yes	0	7	5
85	R:R:D274	R:R:Y279	17.5674	4.6	No	Yes	3	2	1
86	R:R:D274	R:R:I281	14.1705	8.4	No	No	3	2	2
87	R:R:D103	R:R:S107	32.0146	2.94	Yes	No	1	6	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D103	14.3	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:I104	8.1	1	Yes	No	0	4	0	1
L:L:?1	R:R:S107	8.52	1	Yes	No	0	6	0	1
L:L:?1	R:R:S108	12.17	1	Yes	No	0	5	0	1
L:L:?1	R:R:F112	4.94	1	Yes	No	0	6	0	1
L:L:?1	R:R:F154	10.86	1	Yes	No	0	4	0	1
L:L:?1	R:R:F186	3.95	1	Yes	Yes	0	1	0	1
L:L:?1	R:R:T194	11.95	1	Yes	No	0	5	0	1
L:L:?1	R:R:S198	10.95	1	Yes	No	0	6	0	1
L:L:?1	R:R:F267	9.87	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:F268	2.96	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:I290	5.78	1	Yes	No	0	5	0	1
R:R:D103	R:R:V76	4.38	1	Yes	No	6	7	1	2
R:R:D103	R:R:S107	2.94	1	Yes	No	6	6	1	1
R:R:D103	R:R:Y294	8.05	1	Yes	Yes	6	7	1	2
R:R:A155	R:R:I104	3.25	0	No	No	6	4	2	1
R:R:I104	R:R:I159	2.94	0	No	Yes	4	6	1	2
R:R:S107	R:R:W264	3.71	1	No	Yes	6	8	1	2
R:R:P151	R:R:S108	3.56	0	No	No	8	5	2	1
R:R:F154	R:R:M158	9.95	0	No	Yes	4	5	1	2
R:R:I159	R:R:M158	2.92	0	Yes	Yes	6	5	2	2
R:R:I290	R:R:R179	3.76	0	No	Yes	5	2	1	2
R:R:F186	R:R:V184	3.93	1	Yes	No	1	4	1	2
R:R:F186	R:R:G191	3.01	1	Yes	No	1	4	1	2
R:R:F186	R:R:T194	7.78	1	Yes	No	1	5	1	1
R:R:G191	R:R:T194	3.64	1	No	No	4	5	2	1
R:R:F195	R:R:F268	3.22	0	No	Yes	5	7	2	1
R:R:F268	R:R:S198	5.28	1	Yes	No	7	6	1	1
R:R:F199	R:R:W264	4.01	1	Yes	Yes	8	8	2	2
R:R:F199	R:R:F268	13.93	1	Yes	Yes	8	7	2	1
R:R:F268	R:R:W264	3.01	1	Yes	Yes	7	8	1	2
R:R:F267	R:R:F268	3.22	1	Yes	Yes	5	7	1	1
R:R:F267	R:R:T271	3.89	1	Yes	No	5	5	1	2
R:R:F267	R:R:L289	8.53	1	Yes	No	5	5	1	2
R:R:I290	R:R:Y294	6.04	0	No	Yes	5	7	1	2
L:L:?1	R:R:T197	1.19	1	Yes	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8JLP_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.85
Number of Linked Nodes	263
Number of Links	292
Number of Hubs	38
Number of Links mediated by Hubs	147
Number of Communities	6
Number of Nodes involved in Communities	51
Number of Links involved in Communities	69

Path Summary
Number Of Nodes in MetaPath	88
Number Of Links MetaPath	87
Number of Shortest Paths	50275
Length Of Smallest Path	3
Average Path Length	14.2732
Length of Longest Path	32
Minimum Path Strength	1.365
Average Path Strength	5.49664
Maximum Path Strength	15.415
Minimum Path Correlation	0.7
Average Path Correlation	0.931502
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	50.9702
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.3615
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • D1 dopamine receptor binding • molecular function activator activity • enzyme activator activity • cyclase activator activity • adenylate cyclase activator activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to nitrogen compound • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • adenylate cyclase-activating G protein-coupled receptor signaling pathway • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of multicellular organismal process • establishment of protein localization • nitrogen compound transport • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • regulation of hormone secretion • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • Golgi apparatus subcompartment • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • G protein-coupled amine receptor activity • molecular transducer activity • trace-amine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • electron transport chain • metabolic process • generation of precursor metabolites and energy • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • periplasmic space • endoplasmic reticulum subcompartment • nuclear outer membrane-endoplasmic reticulum membrane network • endoplasmic reticulum • endoplasmic reticulum membrane • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	UJU
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	UJU
Name	Ralmitaront
Synonyms	Ralmitaront
Identifier
Formula	C17 H22 N4 O2
Molecular Weight	314.382
SMILES
PubChem	130429734
Formal Charge	0
Total Atoms	45
Total Chiral Atoms	1
Total Bonds	47
Total Aromatic Bonds	11


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q96RJ0
Sequence	>8JLP_nogp_Chain_R S N D V R A S L Y S L M V L I I L T T L V G N L I V I V S I S H F K Q L H T P T N W L I H S M A T V D F L L G C L V M P Y S M V R S A E H C W Y F G E V F C K I H T S T D I M L S S A S I F H L S F I S I D R Y Y A V C D P L R Y K A K M N I L V I C V M I F I S W S V P A V F A F G M I F L E L N F K G A E E I Y Y K H V H C R G G C S V F F S K I S G V L T F M T S F Y I P G S I M L C V Y Y R I Y L I A K E Q A R L I S D A N Q E R K A V K T L G I V M G V F L I C W C P F F I C T V M D P F L H Y I I P P T L N D V L I W F G Y L N S T F N P M V Y A F F Y P W F R K A L K M M L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9JKQ	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	METH	-	Gs/β1/γ2	2.66	2024-10-16	doi.org/10.1021/acs.jmedchem.4c01961
	9JKQ (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	METH	-		2.66	2024-10-16	doi.org/10.1021/acs.jmedchem.4c01961
	8ZSV	A	Amine	Trace Amine Receptors	TA1	Mus musculus	RO5263397	-	chim(NtGi1-Gs)/β1/γ2	2.96	2024-07-24	10.1016/j.celrep.2024.114505
	8ZSV (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	RO5263397	-		2.96	2024-07-24	10.1016/j.celrep.2024.114505
	8ZSS	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5263397	-	chim(NtGi1-Gs)/β1/γ2	3.07	2024-07-24	10.1016/j.celrep.2024.114505
	8ZSS (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5263397	-		3.07	2024-07-24	10.1016/j.celrep.2024.114505
	8ZSP	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	LSD	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.14	2024-07-24	10.1016/j.celrep.2024.114505
	8ZSP (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	LSD	-		3.14	2024-07-24	10.1016/j.celrep.2024.114505
	8ZSJ	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	-	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-07-24	10.1016/j.celrep.2024.114505
	8ZSJ (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	-	-		2.8	2024-07-24	10.1016/j.celrep.2024.114505
	8UHB	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5256390	-	Gs/β1/γ2	3.35	2024-01-10	10.1038/s41467-023-44601-4
	8UHB (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5256390	-		3.35	2024-01-10	10.1038/s41467-023-44601-4
	8WCC	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Cyclohexylammonium Ion	-	-	3.04	2023-12-27	10.1016/j.cell.2023.10.014
	8WCB	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Cyclohexylammonium Ion	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2023-12-27	10.1016/j.cell.2023.10.014
	8WCB (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Cyclohexylammonium Ion	-		3.1	2023-12-27	10.1016/j.cell.2023.10.014
	8WC9	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8651	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.2	2023-12-27	10.1016/j.cell.2023.10.014
	8WC9 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8651	-		3.2	2023-12-27	10.1016/j.cell.2023.10.014
	8WCA	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	2-Phenylethylamine	-	chim(NtGi1-Gs)/β1/γ2	3.48	2023-12-27	10.1016/j.cell.2023.10.014
	8WCA (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	2-Phenylethylamine	-		3.48	2023-12-27	10.1016/j.cell.2023.10.014
	8WC8	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	ZH8651	-	chim(NtGi1-Gs)/β1/γ2	2.9	2023-12-27	10.1016/j.cell.2023.10.014
	8WC8 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	ZH8651	-		2.9	2023-12-27	10.1016/j.cell.2023.10.014
	8WC7	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8667	-	chim(NtGi1-Gs)/β1/γ2	3.1	2023-12-27	10.1016/j.cell.2023.10.014
	8WC7 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8667	-		3.1	2023-12-27	10.1016/j.cell.2023.10.014
	8WC6	A	Amine	Trace Amine Receptors	TA1	Mus musculus	2-Phenylethylamine	-	chim(NtGi1-Gs)/β1/γ2	3.2	2023-12-27	10.1016/j.cell.2023.10.014
	8WC6 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	2-Phenylethylamine	-		3.2	2023-12-27	10.1016/j.cell.2023.10.014
	8WC5	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Tetramethylammonium Ion	-	chim(NtGi1-Gs)/β1/γ2	3.3	2023-12-27	10.1016/j.cell.2023.10.014
	8WC5 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Tetramethylammonium Ion	-		3.3	2023-12-27	10.1016/j.cell.2023.10.014
	8WC4	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8651	-	chim(NtGi1-Gs)/β1/γ2	3.1	2023-12-27	10.1016/j.cell.2023.10.014
	8WC4 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8651	-		3.1	2023-12-27	10.1016/j.cell.2023.10.014
	8WC3	A	Amine	Trace Amine Receptors	TA1	Mus musculus	SEP-363856	-	chim(NtGi1-Gs)/β1/γ2	3	2023-12-27	10.1016/j.cell.2023.10.014
	8WC3 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	SEP-363856	-		3	2023-12-27	10.1016/j.cell.2023.10.014
	8W8A	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5256390	-	chim(NtGi1L-Gs)/β1/γ2	2.8	2023-11-22	10.1038/s41586-023-06775-1
	8W8A (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5256390	-		2.8	2023-11-22	10.1038/s41586-023-06775-1
	8W89	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	PEA	-	chim(NtGi1L-Gs)/β1/γ2	3	2023-11-22	10.1038/s41586-023-06775-1
	8W89 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	PEA	-		3	2023-11-22	10.1038/s41586-023-06775-1
	8W87	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	METH	-	chim(NtGi1L-Gs)/β1/γ2	2.8	2023-11-22	10.1038/s41586-023-06775-1
	8W87 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	METH	-		2.8	2023-11-22	10.1038/s41586-023-06775-1
	8W88	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	SEP-363856	-	Gs/β1/γ2	2.6	2023-11-22	10.1038/s41586-023-06775-1
	8W88 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	SEP-363856	-		2.6	2023-11-22	10.1038/s41586-023-06775-1
	8JSO	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	AMPH	-	chim(NtGi1-Gs)/β1/γ2	3.4	2023-11-15	10.1038/s41586-023-06804-z
	8JSO (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	AMPH	-		3.4	2023-11-15	10.1038/s41586-023-06804-z
	8JLR	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	A77636	-	chim(NtGi1-Gs)/β1/γ2	3	2023-11-15	10.1038/s41586-023-06804-z
	8JLR (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	A77636	-		3	2023-11-15	10.1038/s41586-023-06804-z
	8JLK	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Ulotaront	-	chim(NtGi1-Gs)/β1/γ2	3.22	2023-11-15	10.1038/s41586-023-06804-z
	8JLK (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Ulotaront	-		3.22	2023-11-15	10.1038/s41586-023-06804-z
	8JLJ	A	Amine	Trace Amine Receptors	TA1	Mus musculus	T1AM	-	chim(NtGi1-Gs)/β1/γ2	3.1	2023-11-15	10.1038/s41586-023-06804-z
	8JLJ (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	T1AM	-		3.1	2023-11-15	10.1038/s41586-023-06804-z
	8JLQ	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Fenoldopam	-	Gs/β1/γ2	2.84	2023-11-15	10.1038/s41586-023-06804-z
	8JLQ (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Fenoldopam	-		2.84	2023-11-15	10.1038/s41586-023-06804-z
	8JLP	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Ralmitaront	-	Gs/β1/γ2	3.23	2023-11-15	10.1038/s41586-023-06804-z
	8JLP (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Ralmitaront	-		3.23	2023-11-15	10.1038/s41586-023-06804-z
	8JLO	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Ulotaront	-	Gs/β1/γ2	3.52	2023-11-15	10.1038/s41586-023-06804-z
	8JLO (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Ulotaront	-		3.52	2023-11-15	10.1038/s41586-023-06804-z
	8JLN	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	T1AM	-	Gs/β1/γ2	3.24	2023-11-15	10.1038/s41586-023-06804-z
	8JLN (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	T1AM	-		3.24	2023-11-15	10.1038/s41586-023-06804-z

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