psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D103	13.46	Yes	Yes	1	0	6
2	L:L:?1	R:R:I104	11.32	Yes	Yes	0	0	4
3	L:L:?1	R:R:S107	10.42	Yes	No	1	0	6
4	L:L:?1	R:R:F186	6.04	Yes	Yes	1	0	1
5	L:L:?1	R:R:W264	3.39	Yes	Yes	1	0	8
6	L:L:?1	R:R:F267	15.7	Yes	Yes	1	0	5
7	L:L:?1	R:R:F268	8.45	Yes	Yes	1	0	7
8	L:L:?1	R:R:Y294	6.97	Yes	Yes	1	0	7
9	R:R:D21	R:R:S19	4.42	No	No	4	4	2
10	R:R:S19	R:R:V22	6.46	No	No	4	2	3
11	R:R:N20	R:R:R23	16.87	No	No	0	5	4
12	R:R:D21	R:R:V22	4.38	No	No	4	4	3
13	R:R:M81	R:R:Y27	3.59	No	No	0	6	6
14	R:R:A85	R:R:Y27	4	No	No	0	5	6
15	R:R:I33	R:R:L29	4.28	No	No	0	7	5
16	R:R:M30	R:R:M81	5.78	No	No	0	6	6
17	R:R:M30	R:R:W291	20.94	No	Yes	0	6	4
18	R:R:M81	R:R:V31	3.04	No	No	0	6	5
19	R:R:I33	R:R:W291	3.52	No	Yes	0	7	4
20	R:R:I33	R:R:L295	7.14	No	No	0	7	5
21	R:R:I34	R:R:P78	5.08	No	No	0	6	8
22	R:R:T298	R:R:T36	3.14	No	No	0	7	5
23	R:R:M77	R:R:T37	4.52	Yes	No	0	7	7
24	R:R:T298	R:R:T37	10.99	No	No	0	7	7
25	R:R:F70	R:R:L38	7.31	Yes	No	0	7	6
26	R:R:G73	R:R:L38	3.42	No	No	0	7	6
27	R:R:I43	R:R:V39	3.07	No	No	0	7	5
28	R:R:D69	R:R:N41	6.73	Yes	No	0	9	9
29	R:R:F70	R:R:N41	4.83	Yes	No	0	7	9
30	R:R:N41	R:R:P301	8.15	No	No	0	9	9
31	R:R:F70	R:R:L42	8.53	Yes	No	0	7	4
32	R:R:A66	R:R:V44	3.39	No	No	0	9	9
33	R:R:F311	R:R:V44	5.24	Yes	No	0	9	9
34	R:R:H63	R:R:I45	6.63	Yes	No	0	6	8
35	R:R:A66	R:R:I45	3.25	No	No	0	9	8
36	R:R:I45	R:R:T67	4.56	No	No	0	8	6
37	R:R:I48	R:R:S47	3.1	No	No	0	7	8
38	R:R:F311	R:R:S47	7.93	Yes	No	0	9	8
39	R:R:H63	R:R:I48	7.95	Yes	No	0	6	7
40	R:R:F51	R:R:H50	6.79	No	No	0	5	5
41	R:R:H55	R:R:K52	3.93	No	No	0	8	6
42	R:R:L54	R:R:N59	4.12	No	Yes	0	8	9
43	R:R:A314	R:R:L54	4.73	No	No	0	7	8
44	R:R:H55	R:R:W60	9.52	No	No	0	8	4
45	R:R:P57	R:R:T56	3.5	No	No	0	6	8
46	R:R:N59	R:R:T56	10.24	Yes	No	0	9	8
47	R:R:D120	R:R:T58	10.12	Yes	No	3	9	8
48	R:R:T58	R:R:Y131	3.75	No	Yes	3	8	7
49	R:R:N59	R:R:W310	9.04	Yes	No	0	9	6
50	R:R:H63	R:R:W60	5.29	Yes	No	0	6	4
51	R:R:I137	R:R:W60	3.52	No	No	0	2	4
52	R:R:D120	R:R:L61	4.07	Yes	No	0	9	7
53	R:R:I140	R:R:L61	7.14	Yes	No	0	7	7
54	R:R:H113	R:R:S64	11.16	Yes	No	2	8	9
55	R:R:I144	R:R:S64	9.29	No	No	0	7	9
56	R:R:S64	R:R:W148	3.71	No	Yes	2	9	9
57	R:R:H113	R:R:M65	7.88	Yes	No	2	8	9
58	R:R:I117	R:R:M65	4.37	No	No	2	9	9
59	R:R:M65	R:R:Y304	4.79	No	Yes	2	9	9
60	R:R:L106	R:R:V68	2.98	No	Yes	0	6	8
61	R:R:A109	R:R:V68	3.39	No	Yes	0	7	8
62	R:R:H113	R:R:V68	4.15	Yes	Yes	2	8	8
63	R:R:V68	R:R:W148	8.58	Yes	Yes	2	8	9
64	R:R:D69	R:R:S110	7.36	Yes	No	0	9	9
65	R:R:D69	R:R:S297	8.83	Yes	No	0	9	9
66	R:R:D69	R:R:N300	4.04	Yes	No	0	9	9
67	R:R:L71	R:R:L75	5.54	No	No	0	7	5
68	R:R:L72	R:R:V76	4.47	No	Yes	0	7	7
69	R:R:L106	R:R:L72	8.3	No	No	0	6	7
70	R:R:L72	R:R:S297	4.5	No	No	0	7	9
71	R:R:G73	R:R:M77	6.99	No	Yes	0	7	7
72	R:R:H99	R:R:V76	5.54	Yes	Yes	1	5	7
73	R:R:T102	R:R:V76	3.17	No	Yes	0	4	7
74	R:R:D103	R:R:V76	8.76	Yes	Yes	1	6	7
75	R:R:V76	R:R:Y294	3.79	Yes	Yes	1	7	7
76	R:R:M77	R:R:Y294	9.58	Yes	Yes	0	7	7
77	R:R:F91	R:R:Y79	6.19	Yes	No	1	6	5
78	R:R:F95	R:R:Y79	10.32	Yes	No	1	5	5
79	R:R:H99	R:R:Y79	8.71	Yes	No	1	5	5
80	R:R:S80	R:R:Y294	11.45	No	Yes	0	6	7
81	R:R:R83	R:R:W89	4	No	Yes	1	4	7
82	R:R:H99	R:R:R83	7.9	Yes	No	1	5	4
83	R:R:D103	R:R:R83	3.57	Yes	No	1	6	4
84	R:R:I290	R:R:S84	3.1	No	No	0	5	5
85	R:R:S84	R:R:W291	8.65	No	Yes	0	5	4
86	R:R:H87	R:R:Y90	5.44	No	No	0	4	1
87	R:R:F91	R:R:W89	20.04	Yes	Yes	1	6	7
88	R:R:F95	R:R:W89	5.01	Yes	Yes	1	5	7
89	R:R:C96	R:R:W89	15.67	No	Yes	1	9	7
90	R:R:H99	R:R:W89	5.29	Yes	Yes	1	5	7
91	R:R:C182	R:R:W89	11.75	No	Yes	1	9	7
92	R:R:F91	R:R:F95	10.72	Yes	Yes	1	6	5
93	R:R:C182	R:R:C96	7.28	No	No	1	9	9
94	R:R:F160	R:R:K97	3.72	Yes	No	0	4	6
95	R:R:F160	R:R:I98	5.02	Yes	No	0	4	4
96	R:R:I159	R:R:T100	4.56	Yes	No	0	6	4
97	R:R:F156	R:R:S101	14.53	No	No	0	4	6
98	R:R:I159	R:R:S101	9.29	Yes	No	0	6	6
99	R:R:D103	R:R:Y294	12.64	Yes	Yes	1	6	7
100	R:R:A155	R:R:I104	3.25	No	Yes	0	6	4
101	R:R:I104	R:R:V184	3.07	Yes	No	0	4	4
102	R:R:A152	R:R:M105	4.83	No	No	0	3	5
103	R:R:S107	R:R:W264	4.94	No	Yes	1	6	8
104	R:R:P151	R:R:S108	5.34	No	No	0	8	5
105	R:R:S108	R:R:S198	6.52	No	No	0	5	6
106	R:R:I111	R:R:P202	3.39	No	No	0	8	9
107	R:R:I111	R:R:W264	10.57	No	Yes	0	8	8
108	R:R:F112	R:R:F116	3.22	No	Yes	0	6	7
109	R:R:F112	R:R:P151	4.33	No	No	0	6	8
110	R:R:H113	R:R:S147	13.95	Yes	No	0	8	7
111	R:R:H113	R:R:W148	5.29	Yes	Yes	2	8	9
112	R:R:L114	R:R:N300	8.24	No	No	0	9	9
113	R:R:L114	R:R:Y304	7.03	No	Yes	0	9	9
114	R:R:S115	R:R:S118	3.26	No	Yes	0	7	8
115	R:R:P202	R:R:S115	3.56	No	No	0	9	7
116	R:R:I205	R:R:S115	4.64	No	No	0	6	7
117	R:R:F116	R:R:M143	19.9	Yes	No	0	7	6
118	R:R:F116	R:R:I146	5.02	Yes	No	0	7	3
119	R:R:F116	R:R:S147	5.28	Yes	No	0	7	7
120	R:R:I117	R:R:Y304	6.04	No	Yes	2	9	9
121	R:R:M206	R:R:S118	6.13	No	Yes	0	9	8
122	R:R:S118	R:R:V209	3.23	Yes	No	0	8	7
123	R:R:S118	R:R:Y210	5.09	Yes	Yes	0	8	9
124	R:R:D120	R:R:Y131	8.05	Yes	Yes	3	9	7
125	R:R:D120	R:R:M135	8.32	Yes	Yes	3	9	7
126	R:R:R121	R:R:Y308	3.09	No	No	0	9	8
127	R:R:C126	R:R:Y122	16.13	No	No	0	6	8
128	R:R:V209	R:R:Y122	6.31	No	No	0	7	8
129	R:R:R212	R:R:Y122	4.12	No	No	0	5	8
130	R:R:K134	R:R:Y123	5.97	No	No	0	4	4
131	R:R:M135	R:R:Y123	7.18	Yes	No	0	7	4
132	R:R:A124	R:R:Y131	9.34	No	Yes	0	8	7
133	R:R:C126	R:R:V125	3.42	No	No	5	6	8
134	R:R:I213	R:R:V125	4.61	No	No	0	9	8
135	R:R:I216	R:R:V125	3.07	Yes	No	5	5	8
136	R:R:C126	R:R:I216	3.27	No	Yes	5	6	5
137	R:R:D127	R:R:P128	3.22	No	No	0	5	8
138	R:R:D127	R:R:R130	11.91	No	No	0	5	5
139	R:R:D127	R:R:K134	8.3	No	No	0	5	4
140	R:R:M135	R:R:Y131	3.59	Yes	Yes	3	7	7
141	R:R:I140	R:R:M135	4.37	Yes	Yes	0	7	7
142	R:R:N136	R:R:V139	4.43	No	No	0	8	5
143	R:R:C141	R:R:I137	3.27	No	No	0	1	2
144	R:R:I146	R:R:V142	3.07	No	No	0	3	3
145	R:R:F145	R:R:S149	13.21	No	No	0	5	4
146	R:R:S149	R:R:V150	3.23	No	No	0	4	4
147	R:R:P151	R:R:V150	3.53	No	No	0	8	4
148	R:R:F154	R:R:M158	4.98	No	Yes	1	4	5
149	R:R:F154	R:R:T194	5.19	No	No	1	4	5
150	R:R:F154	R:R:T197	9.08	No	No	0	4	4
151	R:R:F156	R:R:F160	3.22	No	Yes	0	4	4
152	R:R:F186	R:R:M158	4.98	Yes	Yes	1	1	5
153	R:R:M158	R:R:S190	3.07	Yes	Yes	1	5	6
154	R:R:M158	R:R:T194	3.01	Yes	No	1	5	5
155	R:R:F160	R:R:I159	3.77	Yes	Yes	0	4	6
156	R:R:E162	R:R:K166	6.75	No	No	0	5	3
157	R:R:F165	R:R:L163	17.05	Yes	No	0	4	6
158	R:R:F165	R:R:N164	8.46	Yes	No	0	4	4
159	R:R:N164	R:R:S190	2.98	No	Yes	0	4	6
160	R:R:E169	R:R:F165	8.16	No	Yes	6	4	4
161	R:R:F165	R:R:Y172	23.73	Yes	Yes	6	4	3
162	R:R:A168	R:R:I171	3.25	No	No	0	3	2
163	R:R:E169	R:R:Y172	3.37	No	Yes	6	4	3
164	R:R:F185	R:R:I171	3.77	Yes	No	0	1	2
165	R:R:V176	R:R:Y172	5.05	No	Yes	0	3	3
166	R:R:F185	R:R:Y172	14.44	Yes	Yes	0	1	3
167	R:R:H177	R:R:Y173	6.53	No	No	0	4	2
168	R:R:H175	R:R:R179	16.93	No	Yes	7	3	2
169	R:R:H175	R:R:S183	4.18	No	No	7	3	4
170	R:R:F185	R:R:H175	10.18	Yes	No	0	1	3
171	R:R:C178	R:R:R179	5.57	No	Yes	0	4	2
172	R:R:R179	R:R:S183	3.95	Yes	No	7	2	4
173	R:R:F186	R:R:V184	6.55	Yes	No	0	1	4
174	R:R:F185	R:R:Y279	9.28	Yes	No	0	1	1
175	R:R:F186	R:R:S190	5.28	Yes	Yes	1	1	6
176	R:R:F186	R:R:G191	3.01	Yes	No	0	1	4
177	R:R:F186	R:R:T194	10.38	Yes	No	1	1	5
178	R:R:I189	R:R:S187	3.1	No	No	0	4	4
179	R:R:S187	R:R:S190	4.89	No	Yes	0	4	6
180	R:R:F195	R:R:M196	4.98	Yes	No	1	5	5
181	R:R:F195	R:R:F199	5.36	Yes	Yes	1	5	8
182	R:R:F195	R:R:Y200	6.19	Yes	No	1	5	5
183	R:R:F195	R:R:F268	4.29	Yes	Yes	1	5	7
184	R:R:F195	R:R:V272	11.8	Yes	No	0	5	6
185	R:R:M196	R:R:Y200	3.59	No	No	1	5	5
186	R:R:F199	R:R:F260	6.43	Yes	Yes	0	8	9
187	R:R:C265	R:R:F199	5.59	No	Yes	0	6	8
188	R:R:F199	R:R:F268	18.22	Yes	Yes	1	8	7
189	R:R:I201	R:R:P202	3.39	No	No	0	6	9
190	R:R:F260	R:R:G203	3.01	Yes	No	0	9	6
191	R:R:F260	R:R:M206	6.22	Yes	No	0	9	9
192	R:R:L253	R:R:Y210	4.69	No	Yes	0	7	9
193	R:R:V256	R:R:Y210	5.05	No	Yes	0	8	9
194	R:R:M257	R:R:Y210	7.18	No	Yes	0	8	9
195	R:R:Y210	R:R:Y304	2.98	Yes	Yes	0	9	9
196	R:R:L215	R:R:Y211	12.89	No	No	0	4	3
197	R:R:L215	R:R:R212	9.72	No	No	0	4	5
198	R:R:I216	R:R:R212	5.01	Yes	No	0	5	5
199	R:R:K218	R:R:Y214	14.33	No	No	0	6	5
200	R:R:L223	R:R:R222	6.07	No	No	0	4	4
201	R:R:D226	R:R:R222	8.34	No	No	0	4	4
202	R:R:L231	R:R:Q232	3.99	No	No	0	3	5
203	R:R:E246	R:R:K248	10.8	No	No	0	7	8
204	R:R:R247	R:R:V250	9.15	No	No	0	5	8
205	R:R:I255	R:R:K251	4.36	No	No	8	6	6
206	R:R:F307	R:R:K251	4.96	No	No	8	7	6
207	R:R:F307	R:R:T252	9.08	No	No	0	7	9
208	R:R:I255	R:R:V303	3.07	No	No	0	6	8
209	R:R:F307	R:R:I255	3.77	No	No	8	7	6
210	R:R:L261	R:R:M257	4.24	No	No	0	6	8
211	R:R:F260	R:R:L261	3.65	Yes	No	0	9	6
212	R:R:F260	R:R:W264	4.01	Yes	Yes	0	9	8
213	R:R:C263	R:R:N296	6.3	No	No	0	8	9
214	R:R:F267	R:R:W264	7.02	Yes	Yes	1	5	8
215	R:R:F268	R:R:W264	8.02	Yes	Yes	1	7	8
216	R:R:G293	R:R:W264	8.44	No	Yes	0	7	8
217	R:R:N296	R:R:W264	9.04	No	Yes	0	9	8
218	R:R:C265	R:R:I269	3.27	No	No	0	6	6
219	R:R:F267	R:R:F268	7.5	Yes	Yes	1	5	7
220	R:R:F267	R:R:T271	7.78	Yes	No	0	5	5
221	R:R:F267	R:R:I290	5.02	Yes	No	0	5	5
222	R:R:C270	R:R:I281	6.55	No	Yes	0	4	2
223	R:R:C270	R:R:L289	3.17	No	No	0	4	5
224	R:R:D274	R:R:Y279	8.05	No	No	0	2	1
225	R:R:I281	R:R:P282	3.39	Yes	No	0	2	1
226	R:R:I281	R:R:N286	5.66	Yes	No	0	2	4
227	R:R:L285	R:R:L289	6.92	No	No	0	4	5
228	R:R:L289	R:R:V288	2.98	No	No	0	5	4
229	R:R:I290	R:R:Y294	3.63	No	Yes	0	5	7
230	R:R:W291	R:R:Y294	10.61	Yes	Yes	0	4	7
231	R:R:N296	R:R:N300	12.26	No	No	0	9	9
232	R:R:F306	R:R:M302	3.73	No	No	0	6	6
233	R:R:V303	R:R:Y304	3.79	No	Yes	0	8	9
234	R:R:A305	R:R:F311	8.32	No	Yes	0	7	9
235	R:R:F306	R:R:F311	5.36	No	Yes	0	6	9
236	R:R:W310	R:R:Y308	9.65	No	No	0	6	8
237	R:R:P309	R:R:R312	7.21	No	No	0	5	8
238	R:R:F311	R:R:W310	4.01	Yes	No	0	9	6
239	R:R:I48	R:R:I62	2.94	No	No	0	7	8
240	R:R:I104	R:R:I159	2.94	Yes	Yes	0	4	6
241	R:R:I119	R:R:I205	2.94	No	No	0	6	6
242	R:R:I140	R:R:I144	2.94	Yes	No	0	7	7
243	R:R:A85	R:R:H87	2.93	No	No	0	5	4
244	R:R:I34	R:R:M77	2.92	No	Yes	0	6	7
245	R:R:N59	R:R:T58	2.92	Yes	No	0	9	8
246	R:R:I171	R:R:K174	2.91	No	No	0	2	4
247	R:R:P283	R:R:R179	2.88	No	Yes	0	1	2
248	R:R:I34	R:R:L35	2.85	No	No	0	6	5
249	R:R:I280	R:R:L277	2.85	No	No	0	1	3
250	R:R:L26	R:R:M30	2.83	No	No	0	5	6
251	R:R:L207	R:R:M257	2.83	No	No	0	5	8
252	R:R:D274	R:R:I281	2.8	No	Yes	0	2	2
253	R:R:H63	R:R:S49	2.79	Yes	No	0	6	3
254	R:R:C74	R:R:F70	2.79	No	Yes	0	4	7
255	R:R:P275	R:R:Y279	2.78	No	No	0	4	1
256	R:R:A314	R:R:F51	2.77	No	No	0	7	5
257	R:R:L138	R:R:N136	2.75	No	No	0	4	8
258	R:R:C88	R:R:Y90	2.69	No	No	0	4	1
259	R:R:F91	R:R:V82	2.62	Yes	No	0	6	5
260	R:R:F299	R:R:V259	2.62	No	No	0	6	6
261	R:R:V250	R:R:Y214	2.52	No	No	0	8	5
262	R:R:F292	R:R:I262	2.51	No	No	0	7	6
263	R:R:F276	R:R:K188	2.48	No	No	0	5	3
264	R:R:F299	R:R:L295	2.44	No	No	0	6	5
265	R:R:K132	R:R:Y131	2.39	No	Yes	0	4	7
266	R:R:L215	R:R:Y214	2.34	No	No	0	4	5
267	R:R:M105	R:R:W148	2.33	No	Yes	0	5	9
268	R:R:L71	R:R:W148	2.28	No	Yes	0	7	9
269	R:R:G180	R:R:G181	2.11	No	No	0	4	3
270	R:R:R23	R:R:Y27	2.06	No	No	0	4	6
271	R:R:C182	R:R:G181	1.96	No	No	0	9	3
272	R:R:C265	R:R:P266	1.88	No	No	0	6	9
273	R:R:G40	R:R:V39	1.84	No	No	0	9	5
274	R:R:A217	R:R:A249	1.79	No	No	0	8	8
275	R:R:P282	R:R:T284	1.75	No	No	0	1	3
276	R:R:G157	R:R:L161	1.71	No	No	0	6	4
277	R:R:K188	R:R:P275	1.67	No	No	0	3	4
278	R:R:E93	R:R:G92	1.64	No	No	0	2	8
279	R:R:V192	R:R:V272	1.6	No	No	0	5	6
280	R:R:I205	R:R:S204	1.55	No	No	0	6	4
281	R:R:I98	R:R:V94	1.54	No	No	0	4	1
282	R:R:I140	R:R:V139	1.54	Yes	No	0	7	5
283	R:R:M273	R:R:V272	1.52	No	No	0	4	6
284	R:R:F91	R:R:G92	1.51	Yes	No	1	6	8
285	R:R:F95	R:R:G92	1.51	Yes	No	1	5	8
286	R:R:F292	R:R:G293	1.51	No	No	0	7	7
287	R:R:L42	R:R:V46	1.49	No	No	0	4	4
288	R:R:I43	R:R:L315	1.43	No	No	0	7	7
289	R:R:I224	R:R:N228	1.42	No	No	0	5	4
290	R:R:K166	R:R:L163	1.41	No	No	0	3	6
291	R:R:L277	R:R:M273	1.41	No	No	0	3	4
292	R:R:P309	R:R:Y308	1.39	No	No	0	5	8
293	R:R:H177	R:R:V176	1.38	No	No	0	4	3
294	R:R:I216	R:R:Q220	1.37	Yes	No	0	5	6
295	R:R:D287	R:R:N286	1.35	No	No	0	3	4
296	R:R:N228	R:R:Q229	1.32	No	No	0	4	3
297	R:R:L129	R:R:R130	1.21	No	No	0	7	5
298	R:R:E219	R:R:R222	1.16	No	No	0	3	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.46875	8	1	0
2	R:R:N59	6.58	4	0	9
3	R:R:H63	5.665	4	0	6
4	R:R:V68	4.775	4	2	8
5	R:R:D69	6.74	4	0	9
6	R:R:F70	5.865	4	0	7
7	R:R:V76	5.146	5	1	7
8	R:R:M77	6.0025	4	0	7
9	R:R:W89	10.2933	6	1	7
10	R:R:F91	8.216	5	1	6
11	R:R:F95	6.89	4	1	5
12	R:R:H99	6.86	4	1	5
13	R:R:D103	9.6075	4	1	6
14	R:R:I104	5.145	4	0	4
15	R:R:H113	8.486	5	2	8
16	R:R:F116	8.355	4	0	7
17	R:R:S118	4.4275	4	0	8
18	R:R:D120	7.64	4	3	9
19	R:R:Y131	5.424	5	3	7
20	R:R:M135	5.865	4	3	7
21	R:R:I140	3.9975	4	0	7
22	R:R:W148	4.438	5	2	9
23	R:R:M158	4.01	4	1	5
24	R:R:I159	5.14	4	0	6
25	R:R:F160	3.9325	4	0	4
26	R:R:F165	14.35	4	6	4
27	R:R:Y172	11.6475	4	6	3
28	R:R:R179	7.3325	4	7	2
29	R:R:F185	9.4175	4	0	1
30	R:R:F186	6.04	6	1	1
31	R:R:S190	4.055	4	1	6
32	R:R:F195	6.524	5	1	5
33	R:R:F199	8.9	4	1	8
34	R:R:Y210	4.998	5	0	9
35	R:R:I216	3.18	4	5	5
36	R:R:F260	4.664	5	0	9
37	R:R:W264	6.92875	8	1	8
38	R:R:F267	8.604	5	1	5
39	R:R:F268	9.296	5	1	7
40	R:R:I281	4.6	4	0	2
41	R:R:W291	10.93	4	0	4
42	R:R:Y294	8.38143	7	1	7
43	R:R:Y304	4.926	5	2	9
44	R:R:F311	6.172	5	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y294	36.2215	6.97	Yes	Yes	1	0	7
2	R:R:W291	R:R:Y294	12.8684	10.61	Yes	Yes	0	4	7
3	L:L:?1	R:R:D103	32.9377	13.46	Yes	Yes	1	0	6
4	R:R:D103	R:R:V76	30.5324	8.76	Yes	Yes	1	6	7
5	R:R:L72	R:R:V76	83.3294	4.47	No	Yes	0	7	7
6	R:R:L106	R:R:L72	86.2648	8.3	No	No	0	6	7
7	R:R:L106	R:R:V68	86.3265	2.98	No	Yes	0	6	8
8	R:R:H113	R:R:V68	44.9427	4.15	Yes	Yes	2	8	8
9	R:R:H113	R:R:S64	60.158	11.16	Yes	No	2	8	9
10	R:R:I144	R:R:S64	100	9.29	No	No	0	7	9
11	R:R:I140	R:R:I144	99.2799	2.94	Yes	No	0	7	7
12	R:R:I140	R:R:L61	29.959	7.14	Yes	No	0	7	7
13	R:R:D120	R:R:L61	29.1055	4.07	Yes	No	0	9	7
14	R:R:D120	R:R:T58	56.8542	10.12	Yes	No	3	9	8
15	R:R:N59	R:R:T58	82.8444	2.92	Yes	No	0	9	8
16	R:R:N59	R:R:W310	63.7302	9.04	Yes	No	0	9	6
17	R:R:F311	R:R:W310	50.195	4.01	Yes	No	0	9	6
18	R:R:F311	R:R:V44	11.1865	5.24	Yes	No	0	9	9
19	R:R:V76	R:R:Y294	44.8493	3.79	Yes	Yes	1	7	7
20	R:R:V68	R:R:W148	41.5555	8.58	Yes	Yes	2	8	9
21	R:R:S64	R:R:W148	40.5571	3.71	No	Yes	2	9	9
22	R:R:I140	R:R:M135	66.4289	4.37	Yes	Yes	0	7	7
23	R:R:D120	R:R:M135	29.4906	8.32	Yes	Yes	3	9	7
24	R:R:M135	R:R:Y131	31.3242	3.59	Yes	Yes	3	7	7
25	R:R:T58	R:R:Y131	28.7055	3.75	No	Yes	3	8	7
26	R:R:F311	R:R:S47	27.9587	7.93	Yes	No	0	9	8
27	R:R:I48	R:R:S47	25.1784	3.1	No	No	0	7	8
28	R:R:H63	R:R:I48	19.6143	7.95	Yes	No	0	6	7
29	R:R:L54	R:R:N59	11.2465	4.12	No	Yes	0	8	9
30	R:R:H63	R:R:W60	14.0502	5.29	Yes	No	0	6	4
31	R:R:M65	R:R:Y304	21.0311	4.79	No	Yes	2	9	9
32	R:R:H99	R:R:V76	11.9949	5.54	Yes	Yes	1	5	7
33	L:L:?1	R:R:I104	13.2334	11.32	Yes	Yes	0	0	4
34	R:R:I104	R:R:I159	10.6814	2.94	Yes	Yes	0	4	6
35	L:L:?1	R:R:F186	47.723	6.04	Yes	Yes	1	0	1
36	R:R:S118	R:R:Y210	10.4064	5.09	Yes	Yes	0	8	9
37	R:R:W310	R:R:Y308	11.2432	9.65	No	No	0	6	8
38	R:R:F186	R:R:S190	39.2436	5.28	Yes	Yes	1	1	6
39	R:R:N164	R:R:S190	36.3582	2.98	No	Yes	0	4	6
40	R:R:F165	R:R:N164	35.3097	8.46	Yes	No	0	4	4
41	R:R:F165	R:R:Y172	29.9723	23.73	Yes	Yes	6	4	3
42	R:R:F185	R:R:Y172	25.7234	14.44	Yes	Yes	0	1	3
43	R:R:F185	R:R:Y279	15.8671	9.28	Yes	No	0	1	1
44	L:L:?1	R:R:F268	10.0347	8.45	Yes	Yes	1	0	7
45	R:R:F195	R:R:F268	10.293	4.29	Yes	Yes	1	5	7
46	R:R:D274	R:R:Y279	11.3999	8.05	No	No	0	2	1
47	R:R:D274	R:R:I281	10.2747	2.8	No	Yes	0	2	2
48	R:R:H113	R:R:M65	21.3979	7.88	Yes	No	2	8	9
49	R:R:Y210	R:R:Y304	14.2369	2.98	Yes	Yes	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D103	13.46	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:I104	11.32	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:S107	10.42	1	Yes	No	0	6	0	1
L:L:?1	R:R:F186	6.04	1	Yes	Yes	0	1	0	1
L:L:?1	R:R:W264	3.39	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F267	15.7	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:F268	8.45	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:Y294	6.97	1	Yes	Yes	0	7	0	1
R:R:D103	R:R:V76	8.76	1	Yes	Yes	6	7	1	2
R:R:V76	R:R:Y294	3.79	1	Yes	Yes	7	7	2	1
R:R:M77	R:R:Y294	9.58	0	Yes	Yes	7	7	2	1
R:R:S80	R:R:Y294	11.45	0	No	Yes	6	7	2	1
R:R:D103	R:R:R83	3.57	1	Yes	No	6	4	1	2
R:R:D103	R:R:Y294	12.64	1	Yes	Yes	6	7	1	1
R:R:A155	R:R:I104	3.25	0	No	Yes	6	4	2	1
R:R:I104	R:R:V184	3.07	0	Yes	No	4	4	1	2
R:R:S107	R:R:W264	4.94	1	No	Yes	6	8	1	1
R:R:I111	R:R:W264	10.57	0	No	Yes	8	8	2	1
R:R:F186	R:R:M158	4.98	1	Yes	Yes	1	5	1	2
R:R:M158	R:R:S190	3.07	1	Yes	Yes	5	6	2	2
R:R:M158	R:R:T194	3.01	1	Yes	No	5	5	2	2
R:R:F186	R:R:V184	6.55	1	Yes	No	1	4	1	2
R:R:F186	R:R:S190	5.28	1	Yes	Yes	1	6	1	2
R:R:F186	R:R:G191	3.01	1	Yes	No	1	4	1	2
R:R:F186	R:R:T194	10.38	1	Yes	No	1	5	1	2
R:R:F195	R:R:F199	5.36	1	Yes	Yes	5	8	2	2
R:R:F195	R:R:F268	4.29	1	Yes	Yes	5	7	2	1
R:R:F199	R:R:F260	6.43	1	Yes	Yes	8	9	2	2
R:R:F199	R:R:F268	18.22	1	Yes	Yes	8	7	2	1
R:R:F260	R:R:W264	4.01	0	Yes	Yes	9	8	2	1
R:R:F267	R:R:W264	7.02	1	Yes	Yes	5	8	1	1
R:R:F268	R:R:W264	8.02	1	Yes	Yes	7	8	1	1
R:R:G293	R:R:W264	8.44	0	No	Yes	7	8	2	1
R:R:N296	R:R:W264	9.04	0	No	Yes	9	8	2	1
R:R:F267	R:R:F268	7.5	1	Yes	Yes	5	7	1	1
R:R:F267	R:R:T271	7.78	1	Yes	No	5	5	1	2
R:R:F267	R:R:I290	5.02	1	Yes	No	5	5	1	2
R:R:I290	R:R:Y294	3.63	0	No	Yes	5	7	2	1
R:R:W291	R:R:Y294	10.61	0	Yes	Yes	4	7	2	1
R:R:I104	R:R:I159	2.94	0	Yes	Yes	4	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8W89_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.98
Number of Linked Nodes	265
Number of Links	298
Number of Hubs	44
Number of Links mediated by Hubs	162
Number of Communities	8
Number of Nodes involved in Communities	52
Number of Links involved in Communities	72

Path Summary
Number Of Nodes in MetaPath	50
Number Of Links MetaPath	49
Number of Shortest Paths	88360
Length Of Smallest Path	3
Average Path Length	16.9581
Length of Longest Path	34
Minimum Path Strength	1.37
Average Path Strength	6.46629
Maximum Path Strength	20.39
Minimum Path Correlation	0.7
Average Path Correlation	0.940485
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	46.8078
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	51.3887
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component	• cellular anatomical structure • endomembrane system • cell periphery • plasma membrane • membrane • membrane-bounded organelle • intracellular anatomical structure • organelle subcompartment • intracellular membrane-bounded organelle • endoplasmic reticulum subcompartment • intracellular organelle • organelle • nuclear outer membrane-endoplasmic reticulum membrane network • endoplasmic reticulum • cytoplasm • organelle membrane • endoplasmic reticulum membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • G-protein beta/gamma-subunit complex binding • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • D1 dopamine receptor binding • dopamine receptor binding • G protein activity • molecular function regulator activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • positive regulation of cell population proliferation • positive regulation of biological process • positive regulation of neural precursor cell proliferation • regulation of cell population proliferation • neural precursor cell proliferation • positive regulation of cellular process • regulation of neural precursor cell proliferation • reactive oxygen species metabolic process • regulation of superoxide metabolic process • positive regulation of reactive oxygen species metabolic process • superoxide metabolic process • positive regulation of metabolic process • superoxide anion generation • metabolic process • positive regulation of superoxide anion generation • regulation of superoxide anion generation • regulation of metabolic process • regulation of reactive oxygen species metabolic process • regulation of calcium ion transport • regulation of localization • transport • regulation of transport • regulation of monoatomic ion transport • establishment of localization • metal ion transport • calcium ion transport • localization • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • negative regulation of signaling • negative regulation of biological process • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • adenylate cyclase-activating adrenergic receptor signaling pathway • negative regulation of response to stimulus • negative regulation of signal transduction • negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell division • regulation of body fluid levels • renal system process • positive regulation of urine volume • regulation of urine volume • regulation of biological quality • regulation of vascular associated smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell proliferation • regulation of smooth muscle cell proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • muscle cell proliferation • vascular associated smooth muscle cell proliferation • gamma-aminobutyric acid signaling pathway • purinergic nucleotide receptor signaling pathway • cell surface receptor signaling pathway • G protein-coupled purinergic receptor signaling pathway • G protein-coupled adenosine receptor signaling pathway • regulation of molecular function • regulation of adenylate cyclase activity • regulation of catalytic activity • negative regulation of molecular function • negative regulation of catalytic activity • negative regulation of adenylate cyclase activity • regulated exocytosis • regulation of calcium ion-dependent exocytosis • negative regulation of transport • negative regulation of regulated secretory pathway • vesicle-mediated transport • regulation of regulated secretory pathway • secretion by cell • regulation of secretion by cell • negative regulation of secretion • negative regulation of exocytosis • negative regulation of secretion by cell • calcium-ion regulated exocytosis • secretion • negative regulation of calcium ion-dependent exocytosis • export from cell • regulation of vesicle-mediated transport • regulation of secretion • exocytosis • regulation of exocytosis • regulation of programmed cell death • negative regulation of apoptotic signaling pathway • negative regulation of programmed cell death • regulation of apoptotic process • cell death • apoptotic signaling pathway • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of apoptotic signaling pathway • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • locomotion • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • trans-synaptic signaling • modulation of chemical synaptic transmission • negative regulation of synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • response to nutrient levels • response to nutrient • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of multicellular organismal process • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • hormone secretion • protein localization to extracellular region • peptide secretion • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • regulation of protein transport • protein secretion • regulation of protein secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • positive regulation of catalytic activity • positive regulation of lyase activity • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • midbody • dense core granule • intracellular vesicle • cytoplasmic vesicle • secretory granule • secretory vesicle • neuronal dense core vesicle • centrosome • microtubule organizing center • cytoskeleton • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • somatodendritic compartment • dendrite • dendritic tree • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • neuron to neuron synapse • hippocampal mossy fiber to CA3 synapse • cell body • ciliary basal body • Golgi apparatus subcompartment • Golgi apparatus • trans-Golgi network membrane • trans-Golgi network
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	PEA
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	PEA
Name	Phenethylamine
Synonyms	benzeneethanamine
Identifier
Formula	C8 H12 N
Molecular Weight	122.188
SMILES
PubChem	448751
Formal Charge	1
Total Atoms	21
Total Chiral Atoms	0
Total Bonds	21
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q96RJ0
Sequence	>8W89_nogp_Chain_R S N D V R A S L Y S L M V L I I L T T L V G N L I V I V S I S H F K Q L H T P T N W L I H S M A T V D F L L G C L V M P Y S M V R S A E H C W Y F G E V F C K I H T S T D I M L S S A S I F H L S F I S I D R Y Y A V C D P L R Y K A K M N I L V I C V M I F I S W S V P A V F A F G M I F L E L N F K G A E E I Y Y K H V H C R G G C S V F F S K I S G V L T F M T S F Y I P G S I M L C V Y Y R I Y L I A K E Q A R L I S D A N Q K L Q E R K A V K T L G I V M G V F L I C W C P F F I C T V M D P F L H Y I I P P T L N D V L I W F G Y L N S T F N P M V Y A F F Y P W F R K A L K Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8WC3	A	Amine	Trace Amine Receptors	TA1	Mus musculus	SEP-363856	-	chim(NtGi1-Gs)/β1/γ2	3	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC3 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	SEP-363856	-		3	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC4	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8651	-	chim(NtGi1-Gs)/β1/γ2	3.1	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC4 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8651	-		3.1	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC5	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Tetramethylammonium Ion	-	chim(NtGi1-Gs)/β1/γ2	3.3	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC5 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Tetramethylammonium Ion	-		3.3	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC6	A	Amine	Trace Amine Receptors	TA1	Mus musculus	2-Phenylethylamine	-	chim(NtGi1-Gs)/β1/γ2	3.2	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC6 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	2-Phenylethylamine	-		3.2	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC7	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8667	-	chim(NtGi1-Gs)/β1/γ2	3.1	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC7 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8667	-		3.1	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC8	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	ZH8651	-	chim(NtGi1-Gs)/β1/γ2	2.9	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC8 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	ZH8651	-		2.9	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC9	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8651	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.2	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC9 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8651	-		3.2	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WCA	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	2-Phenylethylamine	-	chim(NtGi1-Gs)/β1/γ2	3.48	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WCA (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	2-Phenylethylamine	-		3.48	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WCB	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Cyclohexylammonium Ion	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WCB (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Cyclohexylammonium Ion	-		3.1	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WCC	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Cyclohexylammonium Ion	-	-	3.04	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8ZSJ	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	-	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-07-24	doi.org/10.1016/j.celrep.2024.114505
	8ZSJ (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	-	-		2.8	2024-07-24	doi.org/10.1016/j.celrep.2024.114505
	8ZSP	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	LSD	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.14	2024-07-24	doi.org/10.1016/j.celrep.2024.114505
	8ZSP (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	LSD	-		3.14	2024-07-24	doi.org/10.1016/j.celrep.2024.114505
	8ZSS	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5263397	-	chim(NtGi1-Gs)/β1/γ2	3.07	2024-07-24	doi.org/10.1016/j.celrep.2024.114505
	8ZSS (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5263397	-		3.07	2024-07-24	doi.org/10.1016/j.celrep.2024.114505
	8ZSV	A	Amine	Trace Amine Receptors	TA1	Mus musculus	RO5263397	-	chim(NtGi1-Gs)/β1/γ2	2.96	2024-07-24	doi.org/10.1016/j.celrep.2024.114505
	8ZSV (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	RO5263397	-		2.96	2024-07-24	doi.org/10.1016/j.celrep.2024.114505
	8UHB	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5256390	-	Gs/β1/γ2	3.35	2024-01-10	doi.org/10.1038/s41467-023-44601-4
	8UHB (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5256390	-		3.35	2024-01-10	doi.org/10.1038/s41467-023-44601-4
	8W87	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	METH	-	chim(NtGi1L-Gs)/β1/γ2	2.8	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W87 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	METH	-		2.8	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W88	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	SEP-363856	-	Gs/β1/γ2	2.6	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W88 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	SEP-363856	-		2.6	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W89	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	PEA	-	chim(NtGi1L-Gs)/β1/γ2	3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W89 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	PEA	-		3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W8A	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5256390	-	chim(NtGi1L-Gs)/β1/γ2	2.8	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W8A (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5256390	-		2.8	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8JLJ	A	Amine	Trace Amine Receptors	TA1	Mus musculus	T1AM	-	chim(NtGi1-Gs)/β1/γ2	3.1	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLJ (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	T1AM	-		3.1	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLK	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Ulotaront	-	chim(NtGi1-Gs)/β1/γ2	3.22	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLK (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Ulotaront	-		3.22	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLN	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	T1AM	-	Gs/β1/γ2	3.24	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLN (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	T1AM	-		3.24	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLO	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Ulotaront	-	Gs/β1/γ2	3.52	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLO (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Ulotaront	-		3.52	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLP	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Ralmitaront	-	Gs/β1/γ2	3.23	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLP (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Ralmitaront	-		3.23	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLQ	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Fenoldopam	-	Gs/β1/γ2	2.84	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLQ (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Fenoldopam	-		2.84	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLR	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	A77636	-	chim(NtGi1-Gs)/β1/γ2	3	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLR (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	A77636	-		3	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JSO	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	AMPH	-	chim(NtGi1-Gs)/β1/γ2	3.4	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JSO (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	AMPH	-		3.4	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	9JKQ	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	METH	-	Gs/β1/γ2	2.66	2024-10-16	doi.org/10.1021/acs.jmedchem.4c01961
	9JKQ (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	METH	-		2.66	2024-10-16	doi.org/10.1021/acs.jmedchem.4c01961

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