psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D103	14.77	Yes	No	1	0	6
2	L:L:?1	R:R:I104	12.71	Yes	Yes	1	0	4
3	L:L:?1	R:R:S107	10.4	Yes	No	0	0	6
4	L:L:?1	R:R:T194	2.92	Yes	No	1	0	5
5	L:L:?1	R:R:F267	9.64	Yes	Yes	0	0	5
6	L:L:?1	R:R:F268	6.02	Yes	Yes	1	0	7
7	L:L:?1	R:R:Y294	4.64	Yes	Yes	1	0	7
8	R:R:D21	R:R:V22	4.38	No	No	0	4	3
9	R:R:L26	R:R:V22	2.98	No	No	0	5	3
10	R:R:L26	R:R:M30	5.65	No	No	0	5	6
11	R:R:A85	R:R:Y27	5.34	No	No	3	5	6
12	R:R:E86	R:R:Y27	4.49	Yes	No	3	4	6
13	R:R:L29	R:R:S28	4.5	No	No	0	5	5
14	R:R:M30	R:R:M81	5.78	No	No	0	6	6
15	R:R:M30	R:R:W291	9.31	No	No	0	6	4
16	R:R:I33	R:R:W291	3.52	No	No	0	7	4
17	R:R:I34	R:R:L38	2.85	No	No	0	6	6
18	R:R:I34	R:R:M77	2.92	No	Yes	0	6	7
19	R:R:N41	R:R:T37	5.85	No	No	0	9	7
20	R:R:T298	R:R:T37	9.42	No	No	0	7	7
21	R:R:I43	R:R:V39	3.07	No	No	0	7	5
22	R:R:D69	R:R:N41	6.73	Yes	No	0	9	9
23	R:R:N41	R:R:P301	4.89	No	No	0	9	9
24	R:R:L42	R:R:V46	2.98	No	No	0	4	4
25	R:R:F306	R:R:I43	5.02	No	No	0	6	7
26	R:R:A66	R:R:V44	3.39	No	No	0	9	9
27	R:R:A305	R:R:V44	3.39	No	No	0	7	9
28	R:R:H63	R:R:I45	7.95	Yes	Yes	5	6	8
29	R:R:A66	R:R:I45	3.25	No	Yes	0	9	8
30	R:R:I45	R:R:T67	4.56	Yes	No	5	8	6
31	R:R:F311	R:R:S47	5.28	Yes	No	0	9	8
32	R:R:I48	R:R:N59	5.66	No	No	0	7	9
33	R:R:H63	R:R:I48	3.98	Yes	No	0	6	7
34	R:R:F311	R:R:I48	6.28	Yes	No	0	9	7
35	R:R:F51	R:R:Q53	12.88	No	No	0	5	5
36	R:R:F51	R:R:M318	6.22	No	No	0	5	6
37	R:R:L54	R:R:W310	3.42	No	Yes	0	8	6
38	R:R:H55	R:R:W60	5.29	No	No	0	8	4
39	R:R:P57	R:R:T56	5.25	No	No	0	6	8
40	R:R:N59	R:R:T56	7.31	No	No	0	9	8
41	R:R:I137	R:R:P57	3.39	No	No	0	2	6
42	R:R:I140	R:R:P57	3.39	No	No	0	7	6
43	R:R:D120	R:R:T58	7.23	No	No	0	9	8
44	R:R:N59	R:R:W310	5.65	No	Yes	0	9	6
45	R:R:H63	R:R:W60	3.17	Yes	No	0	6	4
46	R:R:I140	R:R:L61	4.28	No	No	0	7	7
47	R:R:H63	R:R:T67	5.48	Yes	No	5	6	6
48	R:R:H113	R:R:S64	4.18	Yes	No	0	8	9
49	R:R:I144	R:R:S64	6.19	No	No	0	7	9
50	R:R:H113	R:R:M65	5.25	Yes	No	0	8	9
51	R:R:A109	R:R:V68	3.39	No	No	0	7	8
52	R:R:S110	R:R:V68	4.85	No	No	0	9	8
53	R:R:V68	R:R:W148	4.9	No	No	0	8	9
54	R:R:D69	R:R:S110	4.42	Yes	No	0	9	9
55	R:R:D69	R:R:S297	5.89	Yes	No	4	9	9
56	R:R:D69	R:R:N300	5.39	Yes	No	4	9	9
57	R:R:L72	R:R:V76	2.98	Yes	Yes	0	7	7
58	R:R:L72	R:R:M77	4.24	Yes	Yes	0	7	7
59	R:R:L106	R:R:L72	5.54	No	Yes	0	6	7
60	R:R:L72	R:R:S297	4.5	Yes	No	0	7	9
61	R:R:C74	R:R:L75	3.17	No	No	0	4	5
62	R:R:H99	R:R:V76	8.3	No	Yes	0	5	7
63	R:R:T102	R:R:V76	3.17	No	Yes	0	4	7
64	R:R:D103	R:R:V76	2.92	No	Yes	0	6	7
65	R:R:M77	R:R:Y294	15.57	Yes	Yes	0	7	7
66	R:R:F91	R:R:Y79	5.16	No	No	2	6	5
67	R:R:F95	R:R:Y79	10.32	No	No	2	5	5
68	R:R:H99	R:R:Y79	7.62	No	No	0	5	5
69	R:R:R83	R:R:S80	6.59	No	No	0	4	6
70	R:R:H99	R:R:S80	5.58	No	No	0	5	6
71	R:R:S80	R:R:Y294	6.36	No	Yes	0	6	7
72	R:R:E86	R:R:V82	5.7	Yes	No	0	4	5
73	R:R:R83	R:R:W89	4	No	Yes	0	4	7
74	R:R:D287	R:R:S84	4.42	No	No	0	3	5
75	R:R:A85	R:R:E86	4.53	No	Yes	3	5	4
76	R:R:C88	R:R:Y90	9.41	No	No	0	4	1
77	R:R:F91	R:R:W89	17.04	No	Yes	2	6	7
78	R:R:F95	R:R:W89	4.01	No	Yes	2	5	7
79	R:R:C96	R:R:W89	5.22	No	Yes	2	9	7
80	R:R:C182	R:R:W89	6.53	No	Yes	2	9	7
81	R:R:F91	R:R:F95	6.43	No	No	2	6	5
82	R:R:C182	R:R:C96	7.28	No	No	2	9	9
83	R:R:F160	R:R:I98	3.77	Yes	No	0	4	4
84	R:R:I104	R:R:T100	3.04	Yes	No	1	4	4
85	R:R:I159	R:R:T100	3.04	No	No	1	6	4
86	R:R:T100	R:R:V184	4.76	No	No	0	4	4
87	R:R:F156	R:R:S101	9.25	No	No	0	4	6
88	R:R:L106	R:R:T102	2.95	No	No	0	6	4
89	R:R:D103	R:R:Y294	5.75	No	Yes	1	6	7
90	R:R:A155	R:R:I104	3.25	No	Yes	0	6	4
91	R:R:I104	R:R:I159	2.94	Yes	No	1	4	6
92	R:R:L106	R:R:M105	4.24	No	No	0	6	5
93	R:R:A152	R:R:M105	3.22	No	No	0	3	5
94	R:R:S107	R:R:W264	3.71	No	Yes	0	6	8
95	R:R:P151	R:R:S108	3.56	No	No	0	8	5
96	R:R:S108	R:R:S198	4.89	No	No	0	5	6
97	R:R:I111	R:R:P202	3.39	No	Yes	0	8	9
98	R:R:I111	R:R:W264	7.05	No	Yes	0	8	8
99	R:R:F112	R:R:P202	2.89	No	Yes	0	6	9
100	R:R:H113	R:R:S147	11.16	Yes	No	0	8	7
101	R:R:H113	R:R:W148	4.23	Yes	No	0	8	9
102	R:R:L114	R:R:Y304	5.86	No	No	0	9	9
103	R:R:P202	R:R:S115	3.56	Yes	No	0	9	7
104	R:R:I205	R:R:S115	3.1	No	No	0	6	7
105	R:R:F116	R:R:M143	12.44	No	No	0	7	6
106	R:R:I117	R:R:R121	3.76	No	No	0	9	9
107	R:R:I117	R:R:Y304	6.04	No	No	0	9	9
108	R:R:M206	R:R:S118	4.6	Yes	No	1	9	8
109	R:R:S118	R:R:V209	4.85	No	No	0	8	7
110	R:R:S118	R:R:Y210	3.82	No	Yes	1	8	9
111	R:R:I119	R:R:Y123	3.63	No	No	0	6	4
112	R:R:I119	R:R:I205	2.94	No	No	0	6	6
113	R:R:D120	R:R:Y131	3.45	No	Yes	6	9	7
114	R:R:D120	R:R:M135	8.32	No	No	6	9	7
115	R:R:R121	R:R:Y308	9.26	No	No	0	9	8
116	R:R:Y122	R:R:Y123	3.97	Yes	No	0	8	4
117	R:R:C126	R:R:Y122	8.06	No	Yes	0	6	8
118	R:R:V209	R:R:Y122	7.57	No	Yes	0	7	8
119	R:R:A124	R:R:Y131	5.34	No	Yes	0	8	7
120	R:R:D127	R:R:P128	3.22	No	No	0	5	8
121	R:R:D127	R:R:R130	11.91	No	No	0	5	5
122	R:R:M135	R:R:Y131	4.79	No	Yes	6	7	7
123	R:R:L138	R:R:N136	4.12	No	No	0	4	8
124	R:R:N136	R:R:V139	4.43	No	No	0	8	5
125	R:R:M143	R:R:V139	3.04	No	No	0	6	5
126	R:R:I140	R:R:I144	2.94	No	No	0	7	7
127	R:R:S149	R:R:V150	3.23	No	No	0	4	4
128	R:R:P151	R:R:V150	3.53	No	No	0	8	4
129	R:R:F154	R:R:M158	3.73	No	Yes	0	4	5
130	R:R:F156	R:R:F160	6.43	No	Yes	0	4	4
131	R:R:M158	R:R:N164	2.8	Yes	No	0	5	4
132	R:R:F186	R:R:M158	3.73	Yes	Yes	1	1	5
133	R:R:M158	R:R:S190	4.6	Yes	No	1	5	6
134	R:R:M158	R:R:T194	3.01	Yes	No	1	5	5
135	R:R:L161	R:R:L163	4.15	No	No	0	4	6
136	R:R:E162	R:R:F165	7	No	No	0	5	4
137	R:R:F165	R:R:N164	6.04	No	No	0	4	4
138	R:R:F165	R:R:Y172	13.41	No	No	0	4	3
139	R:R:E169	R:R:Y173	3.37	No	No	0	4	2
140	R:R:E170	R:R:K174	9.45	No	No	0	3	4
141	R:R:F185	R:R:I171	5.02	Yes	Yes	7	1	2
142	R:R:I171	R:R:Y279	3.63	Yes	No	7	2	1
143	R:R:V176	R:R:Y172	3.79	No	No	0	3	3
144	R:R:F185	R:R:Y172	9.28	Yes	No	0	1	3
145	R:R:H175	R:R:R179	9.03	No	No	0	3	2
146	R:R:H175	R:R:S183	8.37	No	No	0	3	4
147	R:R:F185	R:R:H175	9.05	Yes	No	0	1	3
148	R:R:C178	R:R:R179	6.96	No	No	0	4	2
149	R:R:G180	R:R:R179	3	No	No	0	4	2
150	R:R:F186	R:R:V184	3.93	Yes	No	0	1	4
151	R:R:F185	R:R:Y279	4.13	Yes	No	7	1	1
152	R:R:F186	R:R:S190	5.28	Yes	No	1	1	6
153	R:R:F186	R:R:G191	3.01	Yes	No	0	1	4
154	R:R:F186	R:R:T194	7.78	Yes	No	1	1	5
155	R:R:K188	R:R:S187	3.06	No	No	0	3	4
156	R:R:I189	R:R:K188	2.91	No	No	0	4	3
157	R:R:L193	R:R:T197	2.95	No	No	0	3	4
158	R:R:F195	R:R:M196	4.98	No	No	0	5	5
159	R:R:F195	R:R:F268	4.29	No	Yes	0	5	7
160	R:R:F195	R:R:V272	10.49	No	No	0	5	6
161	R:R:M196	R:R:Y200	5.99	No	No	0	5	5
162	R:R:F199	R:R:F260	3.22	Yes	Yes	1	8	9
163	R:R:F199	R:R:W264	4.01	Yes	Yes	1	8	8
164	R:R:F199	R:R:F268	18.22	Yes	Yes	1	8	7
165	R:R:I201	R:R:P202	3.39	No	Yes	0	6	9
166	R:R:I201	R:R:I205	2.94	No	No	0	6	6
167	R:R:M206	R:R:Y210	3.59	Yes	Yes	1	9	9
168	R:R:M206	R:R:M257	2.89	Yes	No	1	9	8
169	R:R:F260	R:R:M206	7.46	Yes	Yes	1	9	9
170	R:R:L207	R:R:M257	2.83	No	No	0	5	8
171	R:R:L253	R:R:Y210	5.86	No	Yes	0	7	9
172	R:R:M257	R:R:Y210	5.99	No	Yes	1	8	9
173	R:R:L215	R:R:Y211	10.55	No	No	0	4	3
174	R:R:K218	R:R:R247	4.95	No	No	0	6	5
175	R:R:L223	R:R:R222	6.07	No	No	0	4	4
176	R:R:I224	R:R:N228	2.83	No	No	0	5	4
177	R:R:K230	R:R:L231	2.82	No	No	0	3	3
178	R:R:I233	R:R:Q232	5.49	No	No	0	2	5
179	R:R:F307	R:R:T252	3.89	No	No	0	7	9
180	R:R:V256	R:R:V303	3.21	No	No	0	8	8
181	R:R:V256	R:R:Y304	3.79	No	No	0	8	9
182	R:R:F260	R:R:W264	7.02	Yes	Yes	1	9	8
183	R:R:C263	R:R:N296	11.02	No	No	0	8	9
184	R:R:F268	R:R:W264	4.01	Yes	Yes	1	7	8
185	R:R:G293	R:R:W264	5.63	No	Yes	0	7	8
186	R:R:N296	R:R:W264	7.91	No	Yes	0	9	8
187	R:R:C265	R:R:I269	3.27	No	No	0	6	6
188	R:R:F267	R:R:T271	5.19	Yes	No	0	5	5
189	R:R:F267	R:R:L289	3.65	Yes	No	0	5	5
190	R:R:F267	R:R:I290	3.77	Yes	No	0	5	5
191	R:R:C270	R:R:L289	4.76	No	No	0	4	5
192	R:R:D274	R:R:I281	7	No	No	0	2	2
193	R:R:I280	R:R:L277	2.85	No	No	0	1	3
194	R:R:I281	R:R:P282	3.39	No	Yes	0	2	1
195	R:R:I281	R:R:N286	2.83	No	No	0	2	4
196	R:R:P282	R:R:T284	3.5	Yes	No	0	1	3
197	R:R:L285	R:R:P282	3.28	No	Yes	0	4	1
198	R:R:D287	R:R:V288	4.38	No	No	0	3	4
199	R:R:F292	R:R:V288	6.55	No	No	0	7	4
200	R:R:W291	R:R:Y294	14.47	No	Yes	0	4	7
201	R:R:F299	R:R:L295	9.74	No	No	0	6	5
202	R:R:N296	R:R:N300	5.45	No	No	0	9	9
203	R:R:N300	R:R:S297	2.98	No	No	4	9	9
204	R:R:A305	R:R:F311	4.16	No	Yes	0	7	9
205	R:R:F306	R:R:F311	5.36	No	Yes	0	6	9
206	R:R:F307	R:R:Y308	6.19	No	No	0	7	8
207	R:R:W310	R:R:Y308	8.68	Yes	No	0	6	8
208	R:R:F311	R:R:W310	7.02	Yes	Yes	0	9	6
209	R:R:C265	R:R:F199	2.79	No	Yes	0	6	8
210	R:R:L71	R:R:L75	2.77	No	No	0	7	5
211	R:R:D127	R:R:K134	2.77	No	No	0	5	4
212	R:R:E93	R:R:K97	2.7	No	No	0	2	6
213	R:R:P309	R:R:W310	2.7	No	Yes	0	5	6
214	R:R:A249	R:R:Y214	2.67	No	No	0	8	5
215	R:R:L54	R:R:Q53	2.66	No	No	0	8	5
216	R:R:F116	R:R:S147	2.64	No	No	0	7	7
217	R:R:F145	R:R:S149	2.64	No	No	0	5	4
218	R:R:R222	R:R:S225	2.64	No	No	0	4	4
219	R:R:V250	R:R:Y214	2.52	No	No	0	8	5
220	R:R:F70	R:R:I45	2.51	No	Yes	0	7	8
221	R:R:F116	R:R:I146	2.51	No	No	0	7	3
222	R:R:I216	R:R:R212	2.51	No	No	0	5	5
223	R:R:F299	R:R:M302	2.49	No	No	0	6	6
224	R:R:F160	R:R:K97	2.48	Yes	No	0	4	6
225	R:R:F276	R:R:K188	2.48	No	No	0	5	3
226	R:R:F307	R:R:K251	2.48	No	No	0	7	6
227	R:R:F260	R:R:L261	2.44	Yes	No	0	9	6
228	R:R:L129	R:R:R130	2.43	No	No	0	7	5
229	R:R:I213	R:R:Y210	2.42	No	Yes	0	9	9
230	R:R:M81	R:R:Y27	2.39	No	No	0	6	6
231	R:R:M135	R:R:Y123	2.39	No	No	0	7	4
232	R:R:G180	R:R:G181	2.11	No	No	0	4	3
233	R:R:P282	R:R:P283	1.95	Yes	No	0	1	1
234	R:R:C265	R:R:P266	1.88	No	No	0	6	9
235	R:R:G40	R:R:V39	1.84	No	No	0	9	5
236	R:R:G73	R:R:T37	1.82	No	No	0	7	7
237	R:R:A217	R:R:A249	1.79	No	No	0	8	8
238	R:R:C208	R:R:S204	1.72	No	No	0	4	4
239	R:R:C263	R:R:V259	1.71	No	No	0	8	6
240	R:R:A124	R:R:V125	1.7	No	No	0	8	8
241	R:R:M77	R:R:P78	1.68	Yes	No	0	7	8
242	R:R:M105	R:R:P151	1.68	No	No	0	5	8
243	R:R:E93	R:R:G92	1.64	No	No	0	2	8
244	R:R:C141	R:R:I137	1.64	No	No	0	1	2
245	R:R:S25	R:R:S28	1.63	No	No	0	4	5
246	R:R:S187	R:R:S190	1.63	No	No	0	4	6
247	R:R:S25	R:R:V22	1.62	No	No	0	4	3
248	R:R:A168	R:R:I171	1.62	No	Yes	0	3	2
249	R:R:D274	R:R:P275	1.61	No	No	0	2	4
250	R:R:S101	R:R:T102	1.6	No	No	0	6	4
251	R:R:C74	R:R:L38	1.59	No	No	0	4	6
252	R:R:A314	R:R:L54	1.58	No	No	0	7	8
253	R:R:T298	R:R:T36	1.57	No	No	0	7	5
254	R:R:I45	R:R:S49	1.55	Yes	No	0	8	3
255	R:R:I62	R:R:V44	1.54	No	No	0	8	9
256	R:R:I255	R:R:V259	1.54	No	No	0	6	6
257	R:R:I255	R:R:V303	1.54	No	No	0	6	8
258	R:R:M81	R:R:V31	1.52	No	No	0	6	5
259	R:R:C88	R:R:E86	1.52	No	Yes	0	4	4
260	R:R:M196	R:R:V192	1.52	No	No	0	5	5
261	R:R:L315	R:R:S47	1.5	No	No	0	7	8
262	R:R:L138	R:R:V142	1.49	No	No	0	4	3
263	R:R:I269	R:R:M273	1.46	No	No	0	6	4
264	R:R:E93	R:R:V94	1.43	No	No	0	2	1
265	R:R:K166	R:R:L163	1.41	No	No	0	3	6
266	R:R:K218	R:R:L215	1.41	No	No	0	6	4
267	R:R:D274	R:R:M273	1.39	No	No	0	2	4
268	R:R:P275	R:R:Y279	1.39	No	No	0	4	1
269	R:R:A221	R:R:R247	1.38	No	No	0	5	5
270	R:R:E170	R:R:I171	1.37	No	Yes	0	3	2
271	R:R:I216	R:R:Q220	1.37	No	No	0	5	6
272	R:R:L223	R:R:Q220	1.33	No	No	0	4	6
273	R:R:H278	R:R:I280	1.33	No	No	0	1	1
274	R:R:H55	R:R:K52	1.31	No	No	0	8	6
275	R:R:H177	R:R:K174	1.31	No	No	0	4	4
276	R:R:R247	R:R:V250	1.31	No	No	0	5	8
277	R:R:F299	R:R:T298	1.3	No	No	0	6	7
278	R:R:E219	R:R:Q220	1.27	No	No	0	3	6
279	R:R:V176	R:R:Y173	1.26	No	No	0	3	2
280	R:R:F160	R:R:L161	1.22	Yes	No	0	4	4
281	R:R:K132	R:R:Y131	1.19	No	Yes	0	4	7
282	R:R:L253	R:R:Y214	1.17	No	No	0	7	5
283	R:R:F51	R:R:H50	1.13	No	No	0	5	5
284	R:R:R212	R:R:Y122	1.03	No	Yes	0	5	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.72857	7	1	0
2	R:R:I45	3.964	5	5	8
3	R:R:H63	5.145	4	5	6
4	R:R:D69	5.6075	4	4	9
5	R:R:L72	4.315	4	0	7
6	R:R:V76	4.3425	4	0	7
7	R:R:M77	6.1025	4	0	7
8	R:R:E86	4.06	4	3	4
9	R:R:W89	7.36	5	2	7
10	R:R:I104	5.485	4	1	4
11	R:R:H113	6.205	4	0	8
12	R:R:Y122	5.1575	4	0	8
13	R:R:Y131	3.6925	4	6	7
14	R:R:M158	3.574	5	1	5
15	R:R:F160	3.475	4	0	4
16	R:R:I171	2.91	4	7	2
17	R:R:F185	6.87	4	7	1
18	R:R:F186	4.746	5	1	1
19	R:R:F199	7.06	4	1	8
20	R:R:P202	3.3075	4	0	9
21	R:R:M206	4.635	4	1	9
22	R:R:Y210	4.336	5	1	9
23	R:R:F260	5.035	4	1	9
24	R:R:W264	5.62	7	1	8
25	R:R:F267	5.5625	4	0	5
26	R:R:F268	8.135	4	1	7
27	R:R:P282	3.03	4	0	1
28	R:R:Y294	9.358	5	1	7
29	R:R:W310	5.494	5	0	6
30	R:R:F311	5.62	5	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y294	66.9058	4.64	Yes	Yes	1	0	7
2	R:R:W291	R:R:Y294	36.989	14.47	No	Yes	0	4	7
3	R:R:M30	R:R:W291	32.7981	9.31	No	No	0	6	4
4	R:R:L26	R:R:M30	13.4552	5.65	No	No	0	5	6
5	R:R:L26	R:R:V22	11.2402	2.98	No	No	0	5	3
6	R:R:M30	R:R:M81	17.851	5.78	No	No	0	6	6
7	R:R:M81	R:R:Y27	13.4438	2.39	No	No	0	6	6
8	R:R:M77	R:R:Y294	28.9944	15.57	Yes	Yes	0	7	7
9	R:R:I34	R:R:M77	11.5249	2.92	No	Yes	0	6	7
10	L:L:?1	R:R:D103	38.7883	14.77	Yes	No	1	0	6
11	R:R:D103	R:R:V76	38.9363	2.92	No	Yes	0	6	7
12	R:R:L72	R:R:V76	26.4947	2.98	Yes	Yes	0	7	7
13	R:R:L72	R:R:S297	56.2578	4.5	Yes	No	0	7	9
14	R:R:D69	R:R:S297	42.5065	5.89	Yes	No	4	9	9
15	R:R:D69	R:R:N41	21.4668	6.73	Yes	No	0	9	9
16	R:R:L72	R:R:M77	24.4847	4.24	Yes	Yes	0	7	7
17	L:L:?1	R:R:S107	57.0721	10.4	Yes	No	0	0	6
18	R:R:S107	R:R:W264	57.26	3.71	No	Yes	0	6	8
19	R:R:N296	R:R:W264	100	7.91	No	Yes	0	9	8
20	R:R:N296	R:R:N300	48.4968	5.45	No	No	0	9	9
21	R:R:D69	R:R:N300	34.1419	5.39	Yes	No	4	9	9
22	L:L:?1	R:R:F268	86.3683	6.02	Yes	Yes	1	0	7
23	R:R:F268	R:R:W264	61.4224	4.01	Yes	Yes	1	7	8
24	R:R:N41	R:R:T37	16.7749	5.85	No	No	0	9	7
25	R:R:T298	R:R:T37	12.0374	9.42	No	No	0	7	7
26	R:R:C263	R:R:N296	70.4874	11.02	No	No	0	8	9
27	R:R:C263	R:R:V259	69.0354	1.71	No	No	0	8	6
28	R:R:I255	R:R:V259	67.6062	1.54	No	No	0	6	6
29	R:R:I255	R:R:V303	66.1884	1.54	No	No	0	6	8
30	R:R:V256	R:R:V303	64.7705	3.21	No	No	0	8	8
31	R:R:V256	R:R:Y304	63.3527	3.79	No	No	0	8	9
32	R:R:I117	R:R:Y304	60.7106	6.04	No	No	0	9	9
33	R:R:I117	R:R:R121	59.3839	3.76	No	No	0	9	9
34	R:R:R121	R:R:Y308	58.0515	9.26	No	No	0	9	8
35	R:R:W310	R:R:Y308	52.7218	8.68	Yes	No	0	6	8
36	R:R:F311	R:R:W310	33.0714	7.02	Yes	Yes	0	9	6
37	R:R:F306	R:R:F311	10.7448	5.36	No	Yes	0	6	9
38	R:R:N59	R:R:W310	20.6013	5.65	No	Yes	0	9	6
39	R:R:I48	R:R:N59	21.4042	5.66	No	No	0	7	9
40	R:R:H63	R:R:I48	24.5587	3.98	Yes	No	0	6	7
41	R:R:F311	R:R:I48	15.2033	6.28	Yes	No	0	9	7
42	R:R:L54	R:R:W310	13.626	3.42	No	Yes	0	8	6
43	R:R:D69	R:R:S110	59.7996	4.42	Yes	No	0	9	9
44	R:R:S110	R:R:V68	58.097	4.85	No	No	0	9	8
45	R:R:V68	R:R:W148	54.6806	4.9	No	No	0	8	9
46	R:R:H113	R:R:W148	52.9666	4.23	Yes	No	0	8	9
47	R:R:H113	R:R:S64	35.4288	4.18	Yes	No	0	8	9
48	R:R:I144	R:R:S64	33.6237	6.19	No	No	0	7	9
49	R:R:I140	R:R:I144	31.8187	2.94	No	No	0	7	7
50	R:R:I140	R:R:P57	28.1972	3.39	No	No	0	7	6
51	R:R:P57	R:R:T56	22.7138	5.25	No	No	0	6	8
52	R:R:I111	R:R:W264	42.7058	7.05	No	Yes	0	8	8
53	R:R:I111	R:R:P202	40.9577	3.39	No	Yes	0	8	9
54	R:R:P202	R:R:S115	18.7792	3.56	Yes	No	0	9	7
55	R:R:I205	R:R:S115	16.9514	3.1	No	No	0	6	7
56	R:R:I119	R:R:I205	30.3496	2.94	No	No	0	6	6
57	R:R:I119	R:R:Y123	26.8364	3.63	No	No	0	6	4
58	R:R:M135	R:R:Y123	40.0125	2.39	No	No	0	7	4
59	R:R:D120	R:R:M135	11.4395	8.32	No	No	6	9	7
60	R:R:I201	R:R:P202	18.7792	3.39	No	Yes	0	6	9
61	R:R:I201	R:R:I205	16.9514	2.94	No	No	0	6	6
62	R:R:F260	R:R:W264	58.1426	7.02	Yes	Yes	1	9	8
63	R:R:F260	R:R:M206	78.4079	7.46	Yes	Yes	1	9	9
64	R:R:M206	R:R:S118	44.061	4.6	Yes	No	1	9	8
65	R:R:S118	R:R:V209	43.4404	4.85	No	No	0	8	7
66	R:R:V209	R:R:Y122	41.1684	7.57	No	Yes	0	7	8
67	R:R:Y122	R:R:Y123	20.4134	3.97	Yes	No	0	8	4
68	R:R:F199	R:R:F268	27.5026	18.22	Yes	Yes	1	8	7
69	R:R:F199	R:R:F260	24.5302	3.22	Yes	Yes	1	8	9
70	R:R:L106	R:R:L72	26.3182	5.54	No	Yes	0	6	7
71	R:R:T102	R:R:V76	30.0592	3.17	No	Yes	0	4	7
72	R:R:L106	R:R:T102	12.6352	2.95	No	No	0	6	4
73	R:R:H99	R:R:V76	13.3356	8.3	No	Yes	0	5	7
74	R:R:S80	R:R:Y294	19.2404	6.36	No	Yes	0	6	7
75	R:R:H99	R:R:Y79	13.4267	7.62	No	No	0	5	5
76	R:R:R83	R:R:S80	13.2673	6.59	No	No	0	4	6
77	R:R:R83	R:R:W89	10.7106	4	No	Yes	0	4	7
78	R:R:S101	R:R:T102	31.3119	1.6	No	No	0	6	4
79	R:R:F156	R:R:S101	28.5218	9.25	No	No	0	4	6
80	R:R:F156	R:R:F160	25.7203	6.43	No	Yes	0	4	4
81	L:L:?1	R:R:I104	14.8275	12.71	Yes	Yes	1	0	4
82	L:L:?1	R:R:T194	83.1454	2.92	Yes	No	1	0	5
83	R:R:F186	R:R:T194	22.9188	7.78	Yes	No	1	1	5
84	R:R:L106	R:R:M105	20.9486	4.24	No	No	0	6	5
85	R:R:M105	R:R:P151	15.7784	1.68	No	No	0	5	8
86	R:R:H113	R:R:S147	19.1265	11.16	Yes	No	0	8	7
87	R:R:F116	R:R:S147	16.7749	2.64	No	No	0	7	7
88	R:R:F116	R:R:M143	12.0374	12.44	No	No	0	7	6
89	R:R:M206	R:R:Y210	27.7645	3.59	Yes	Yes	1	9	9
90	R:R:M135	R:R:Y131	22.8846	4.79	No	Yes	6	7	7
91	R:R:A124	R:R:Y131	11.485	5.34	No	Yes	0	8	7
92	R:R:M158	R:R:T194	57.5618	3.01	Yes	No	1	5	5
93	R:R:M158	R:R:N164	39.426	2.8	Yes	No	0	5	4
94	R:R:M158	R:R:S190	15.1406	4.6	Yes	No	1	5	6
95	R:R:F186	R:R:S190	14.4858	5.28	Yes	No	1	1	6
96	R:R:F165	R:R:N164	36.6587	6.04	No	No	0	4	4
97	R:R:F165	R:R:Y172	31.1126	13.41	No	No	0	4	3
98	R:R:F185	R:R:Y172	19.9749	9.28	Yes	No	0	1	3
99	R:R:F185	R:R:H175	18.0219	9.05	Yes	No	0	1	3
100	R:R:H175	R:R:R179	12.0886	9.03	No	No	0	3	2
101	R:R:S187	R:R:S190	23.7274	1.63	No	No	0	4	6
102	R:R:K188	R:R:S187	17.8112	3.06	No	No	0	3	4
103	R:R:L253	R:R:Y210	24.5302	5.86	No	Yes	0	7	9
104	R:R:L253	R:R:Y214	22.1102	1.17	No	No	0	7	5
105	R:R:V250	R:R:Y214	14.7819	2.52	No	No	0	8	5
106	R:R:R247	R:R:V250	12.3164	1.31	No	No	0	5	8
107	R:R:R212	R:R:Y122	17.6517	1.03	No	Yes	0	5	8
108	R:R:I216	R:R:R212	15.1634	2.51	No	No	0	5	5
109	R:R:I216	R:R:Q220	12.6637	1.37	No	No	0	5	6
110	R:R:C265	R:R:F199	27.3773	2.79	No	Yes	0	6	8
111	R:R:C265	R:R:I269	24.6783	3.27	No	No	0	6	6
112	L:L:?1	R:R:F267	15.4538	9.64	Yes	Yes	0	0	5
113	R:R:I269	R:R:M273	23.3345	1.46	No	No	0	6	4
114	R:R:D274	R:R:M273	21.9907	1.39	No	No	0	2	4
115	R:R:F160	R:R:K97	11.542	2.48	Yes	No	0	4	6
116	R:R:D274	R:R:P275	13.142	1.61	No	No	0	2	4
117	R:R:N59	R:R:T56	20.8746	7.31	No	No	0	9	8
118	R:R:N300	R:R:S297	13.8595	2.98	No	No	4	9	9
119	R:R:F199	R:R:W264	15.1349	4.01	Yes	Yes	1	8	8
120	R:R:P275	R:R:Y279	11.8722	1.39	No	No	0	4	1

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D103	14.77	1	Yes	No	0	6	0	1
L:L:?1	R:R:I104	12.71	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:S107	10.4	1	Yes	No	0	6	0	1
L:L:?1	R:R:T194	2.92	1	Yes	No	0	5	0	1
L:L:?1	R:R:F267	9.64	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:F268	6.02	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:Y294	4.64	1	Yes	Yes	0	7	0	1
R:R:D103	R:R:V76	2.92	1	No	Yes	6	7	1	2
R:R:M77	R:R:Y294	15.57	0	Yes	Yes	7	7	2	1
R:R:S80	R:R:Y294	6.36	0	No	Yes	6	7	2	1
R:R:I104	R:R:T100	3.04	1	Yes	No	4	4	1	2
R:R:I159	R:R:T100	3.04	1	No	No	6	4	2	2
R:R:D103	R:R:Y294	5.75	1	No	Yes	6	7	1	1
R:R:A155	R:R:I104	3.25	0	No	Yes	6	4	2	1
R:R:I104	R:R:I159	2.94	1	Yes	No	4	6	1	2
R:R:S107	R:R:W264	3.71	0	No	Yes	6	8	1	2
R:R:F186	R:R:M158	3.73	1	Yes	Yes	1	5	2	2
R:R:M158	R:R:T194	3.01	1	Yes	No	5	5	2	1
R:R:F186	R:R:T194	7.78	1	Yes	No	1	5	2	1
R:R:F195	R:R:F268	4.29	0	No	Yes	5	7	2	1
R:R:F199	R:R:W264	4.01	1	Yes	Yes	8	8	2	2
R:R:F199	R:R:F268	18.22	1	Yes	Yes	8	7	2	1
R:R:F268	R:R:W264	4.01	1	Yes	Yes	7	8	1	2
R:R:F267	R:R:T271	5.19	0	Yes	No	5	5	1	2
R:R:F267	R:R:L289	3.65	0	Yes	No	5	5	1	2
R:R:F267	R:R:I290	3.77	0	Yes	No	5	5	1	2
R:R:W291	R:R:Y294	14.47	0	No	Yes	4	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8JLO_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.8
Number of Linked Nodes	265
Number of Links	284
Number of Hubs	30
Number of Links mediated by Hubs	116
Number of Communities	7
Number of Nodes involved in Communities	39
Number of Links involved in Communities	48

Path Summary
Number Of Nodes in MetaPath	121
Number Of Links MetaPath	120
Number of Shortest Paths	57058
Length Of Smallest Path	3
Average Path Length	14.5008
Length of Longest Path	30
Minimum Path Strength	1.3
Average Path Strength	5.31679
Maximum Path Strength	15.02
Minimum Path Correlation	0.71
Average Path Correlation	0.934775
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	51.1554
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	33.8155
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • G protein-coupled amine receptor activity • molecular transducer activity • trace-amine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • electron transport chain • metabolic process • generation of precursor metabolites and energy • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • periplasmic space • endoplasmic reticulum subcompartment • nuclear outer membrane-endoplasmic reticulum membrane network • endoplasmic reticulum • endoplasmic reticulum membrane • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	UJL
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	UJL
Name	SEP-363856
Synonyms	Ulotaront; SEP-363856; SEP-856
Identifier
Formula	C9 H13 N O S
Molecular Weight	183.271
SMILES
PubChem	89532783
Formal Charge	0
Total Atoms	25
Total Chiral Atoms	1
Total Bonds	26
Total Aromatic Bonds	5


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q96RJ0
Sequence	>8JLO_nogp_Chain_R D V R A S L Y S L M V L I I L T T L V G N L I V I V S I S H F K Q L H T P T N W L I H S M A T V D F L L G C L V M P Y S M V R S A E H C W Y F G E V F C K I H T S T D I M L S S A S I F H L S F I S I D R Y Y A V C D P L R Y K A K M N I L V I C V M I F I S W S V P A V F A F G M I F L E L N F K G A E E I Y Y K H V H C R G G C S V F F S K I S G V L T F M T S F Y I P G S I M L C V Y Y R I Y L I A K E Q A R L I S D A N Q K L Q I R K A V K T L G I V M G V F L I C W C P F F I C T V M D P F L H Y I I P P T L N D V L I W F G Y L N S T F N P M V Y A F F Y P W F R K A L K M M L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9JKQ	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	METH	-	Gs/β1/γ2	2.66	2024-10-16	doi.org/10.1021/acs.jmedchem.4c01961
	9JKQ (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	METH	-		2.66	2024-10-16	doi.org/10.1021/acs.jmedchem.4c01961
	8ZSV	A	Amine	Trace Amine Receptors	TA1	Mus musculus	RO5263397	-	chim(NtGi1-Gs)/β1/γ2	2.96	2024-07-24	10.1016/j.celrep.2024.114505
	8ZSV (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	RO5263397	-		2.96	2024-07-24	10.1016/j.celrep.2024.114505
	8ZSS	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5263397	-	chim(NtGi1-Gs)/β1/γ2	3.07	2024-07-24	10.1016/j.celrep.2024.114505
	8ZSS (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5263397	-		3.07	2024-07-24	10.1016/j.celrep.2024.114505
	8ZSP	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	LSD	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.14	2024-07-24	10.1016/j.celrep.2024.114505
	8ZSP (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	LSD	-		3.14	2024-07-24	10.1016/j.celrep.2024.114505
	8ZSJ	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	-	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-07-24	10.1016/j.celrep.2024.114505
	8ZSJ (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	-	-		2.8	2024-07-24	10.1016/j.celrep.2024.114505
	8UHB	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5256390	-	Gs/β1/γ2	3.35	2024-01-10	10.1038/s41467-023-44601-4
	8UHB (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5256390	-		3.35	2024-01-10	10.1038/s41467-023-44601-4
	8WCC	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Cyclohexylammonium Ion	-	-	3.04	2023-12-27	10.1016/j.cell.2023.10.014
	8WCB	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Cyclohexylammonium Ion	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2023-12-27	10.1016/j.cell.2023.10.014
	8WCB (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Cyclohexylammonium Ion	-		3.1	2023-12-27	10.1016/j.cell.2023.10.014
	8WC9	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8651	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.2	2023-12-27	10.1016/j.cell.2023.10.014
	8WC9 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8651	-		3.2	2023-12-27	10.1016/j.cell.2023.10.014
	8WCA	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	2-Phenylethylamine	-	chim(NtGi1-Gs)/β1/γ2	3.48	2023-12-27	10.1016/j.cell.2023.10.014
	8WCA (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	2-Phenylethylamine	-		3.48	2023-12-27	10.1016/j.cell.2023.10.014
	8WC8	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	ZH8651	-	chim(NtGi1-Gs)/β1/γ2	2.9	2023-12-27	10.1016/j.cell.2023.10.014
	8WC8 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	ZH8651	-		2.9	2023-12-27	10.1016/j.cell.2023.10.014
	8WC7	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8667	-	chim(NtGi1-Gs)/β1/γ2	3.1	2023-12-27	10.1016/j.cell.2023.10.014
	8WC7 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8667	-		3.1	2023-12-27	10.1016/j.cell.2023.10.014
	8WC6	A	Amine	Trace Amine Receptors	TA1	Mus musculus	2-Phenylethylamine	-	chim(NtGi1-Gs)/β1/γ2	3.2	2023-12-27	10.1016/j.cell.2023.10.014
	8WC6 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	2-Phenylethylamine	-		3.2	2023-12-27	10.1016/j.cell.2023.10.014
	8WC5	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Tetramethylammonium Ion	-	chim(NtGi1-Gs)/β1/γ2	3.3	2023-12-27	10.1016/j.cell.2023.10.014
	8WC5 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Tetramethylammonium Ion	-		3.3	2023-12-27	10.1016/j.cell.2023.10.014
	8WC4	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8651	-	chim(NtGi1-Gs)/β1/γ2	3.1	2023-12-27	10.1016/j.cell.2023.10.014
	8WC4 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8651	-		3.1	2023-12-27	10.1016/j.cell.2023.10.014
	8WC3	A	Amine	Trace Amine Receptors	TA1	Mus musculus	SEP-363856	-	chim(NtGi1-Gs)/β1/γ2	3	2023-12-27	10.1016/j.cell.2023.10.014
	8WC3 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	SEP-363856	-		3	2023-12-27	10.1016/j.cell.2023.10.014
	8W8A	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5256390	-	chim(NtGi1L-Gs)/β1/γ2	2.8	2023-11-22	10.1038/s41586-023-06775-1
	8W8A (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5256390	-		2.8	2023-11-22	10.1038/s41586-023-06775-1
	8W89	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	PEA	-	chim(NtGi1L-Gs)/β1/γ2	3	2023-11-22	10.1038/s41586-023-06775-1
	8W89 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	PEA	-		3	2023-11-22	10.1038/s41586-023-06775-1
	8W87	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	METH	-	chim(NtGi1L-Gs)/β1/γ2	2.8	2023-11-22	10.1038/s41586-023-06775-1
	8W87 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	METH	-		2.8	2023-11-22	10.1038/s41586-023-06775-1
	8W88	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	SEP-363856	-	Gs/β1/γ2	2.6	2023-11-22	10.1038/s41586-023-06775-1
	8W88 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	SEP-363856	-		2.6	2023-11-22	10.1038/s41586-023-06775-1
	8JSO	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	AMPH	-	chim(NtGi1-Gs)/β1/γ2	3.4	2023-11-15	10.1038/s41586-023-06804-z
	8JSO (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	AMPH	-		3.4	2023-11-15	10.1038/s41586-023-06804-z
	8JLR	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	A77636	-	chim(NtGi1-Gs)/β1/γ2	3	2023-11-15	10.1038/s41586-023-06804-z
	8JLR (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	A77636	-		3	2023-11-15	10.1038/s41586-023-06804-z
	8JLK	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Ulotaront	-	chim(NtGi1-Gs)/β1/γ2	3.22	2023-11-15	10.1038/s41586-023-06804-z
	8JLK (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Ulotaront	-		3.22	2023-11-15	10.1038/s41586-023-06804-z
	8JLJ	A	Amine	Trace Amine Receptors	TA1	Mus musculus	T1AM	-	chim(NtGi1-Gs)/β1/γ2	3.1	2023-11-15	10.1038/s41586-023-06804-z
	8JLJ (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	T1AM	-		3.1	2023-11-15	10.1038/s41586-023-06804-z
	8JLQ	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Fenoldopam	-	Gs/β1/γ2	2.84	2023-11-15	10.1038/s41586-023-06804-z
	8JLQ (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Fenoldopam	-		2.84	2023-11-15	10.1038/s41586-023-06804-z
	8JLP	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Ralmitaront	-	Gs/β1/γ2	3.23	2023-11-15	10.1038/s41586-023-06804-z
	8JLP (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Ralmitaront	-		3.23	2023-11-15	10.1038/s41586-023-06804-z
	8JLO	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Ulotaront	-	Gs/β1/γ2	3.52	2023-11-15	10.1038/s41586-023-06804-z
	8JLO (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Ulotaront	-		3.52	2023-11-15	10.1038/s41586-023-06804-z
	8JLN	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	T1AM	-	Gs/β1/γ2	3.24	2023-11-15	10.1038/s41586-023-06804-z
	8JLN (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	T1AM	-		3.24	2023-11-15	10.1038/s41586-023-06804-z

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