Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:?1 7.66710
2R:R:F50 3.9575406
3R:R:N58 4.385409
4R:R:H62 5.524546
5R:R:D68 5.28857729
6R:R:I75 5.2225406
7R:R:M76 6.808517
8R:R:M80 7.7475416
9R:R:H112 6.9475428
10R:R:Y130 4.08407
11R:R:I134 5.2725407
12R:R:L164 8.26433
13R:R:L170 4.6225434
14R:R:F184 6.6075432
15R:R:S189 3.6625406
16R:R:F194 7.71415
17R:R:F198 5.514517
18R:R:P201 2.714508
19R:R:Y209 5.106519
20R:R:L250 2.564507
21R:R:W261 5.8325817
22R:R:F264 6.83667616
23R:R:F265 6.355616
24R:R:Y276 5.71431
25R:R:P279 2.5875401
26R:R:W288 6.032515
27R:R:Y291 6.562517
28R:R:N297 6.42529
29R:R:Y301 5.704529
30R:R:F308 4.835608
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:?1 R:R:Y291 92.18153.49YesYes107
2R:R:M76 R:R:Y291 90.62015.99YesYes177
3R:R:G72 R:R:M76 93.85443.49NoYes077
4R:R:G72 R:R:L71 94.18363.42NoNo077
5R:R:L71 R:R:S294 99.97343NoNo079
6R:R:D68 R:R:S294 1008.83YesNo099
7R:R:D68 R:R:M64 50.06524.16YesNo299
8R:R:H112 R:R:M64 51.15937.88YesNo289
9R:R:H112 R:R:S63 49.81198.37YesNo289
10R:R:I143 R:R:S63 96.84687.74NoNo079
11R:R:I139 R:R:I143 96.28832.94NoNo077
12R:R:I134 R:R:I139 95.16382.94YesNo077
13R:R:D119 R:R:I134 44.88968.4NoYes097
14R:R:D119 R:R:T57 44.21475.78NoNo098
15R:R:N58 R:R:T57 87.13012.92YesNo098
16R:R:I47 R:R:N58 46.01674.25NoYes089
17R:R:F308 R:R:I47 28.39673.77YesNo088
18R:R:F303 R:R:F308 26.99744.29NoYes048
19R:R:F303 R:R:I42 14.9671.26NoNo046
20R:R:D68 R:R:V67 47.96812.92YesNo098
21R:R:V67 R:R:W147 47.78837.36NoNo089
22R:R:S63 R:R:W147 47.58954.94NoNo299
23R:R:I134 R:R:Y130 46.29024.84YesYes077
24R:R:T57 R:R:Y130 44.32743.75NoYes087
25R:R:N58 R:R:W307 37.00794.52YesNo096
26R:R:F308 R:R:W307 28.34225.01YesNo086
27R:R:I42 R:R:V38 12.07973.07NoNo065
28R:R:H62 R:R:I47 16.68047.95YesNo068
29R:R:F308 R:R:S46 17.99617.93YesNo088
30R:R:F50 R:R:S46 12.05695.28YesNo068
31L:L:?1 R:R:F185 33.98384.83YesNo002
32R:R:F185 R:R:G190 33.48994.52NoNo025
33R:R:G190 R:R:S189 32.90743.71NoYes056
34R:R:N163 R:R:S189 23.24392.98NoYes046
35R:R:I158 R:R:N163 10.2652.83NoNo054
36L:L:?1 R:R:F264 25.580310.87YesYes106
37L:L:?1 R:R:S106 19.92985.96YesNo006
38R:R:S106 R:R:W261 19.50183.71NoYes067
39R:R:F264 R:R:W261 20.31233.01YesYes167
40L:L:?1 R:R:F265 39.34933.62YesYes106
41R:R:F265 R:R:W261 19.69814.01YesYes167
42R:R:F257 R:R:W261 41.84287.02NoYes197
43R:R:F257 R:R:M205 53.88834.98NoNo198
44R:R:F198 R:R:F265 15.76111.79YesYes176
45R:R:F198 R:R:F257 14.01853.22YesNo179
46R:R:M205 R:R:Y209 45.87873.59NoYes189
47R:R:L250 R:R:Y209 35.99864.69YesYes079
48R:R:I212 R:R:L250 16.2651.43NoYes097
49R:R:I212 R:R:V208 14.24391.54NoNo096
50R:R:V208 R:R:Y121 10.186510.09NoNo068
51R:R:L164 R:R:N163 13.06248.24YesNo034
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:D102 12.11 1 Yes No 0 6 0 1
L:L:?1 R:R:I103 12.74 1 Yes No 0 4 0 1
L:L:?1 R:R:S106 5.96 1 Yes No 0 6 0 1
L:L:?1 R:R:F185 4.83 1 Yes No 0 2 0 1
L:L:?1 R:R:F264 10.87 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F265 3.62 1 Yes Yes 0 6 0 1
L:L:?1 R:R:Y291 3.49 1 Yes Yes 0 7 0 1
R:R:D102 R:R:I75 4.2 1 No Yes 6 6 1 2
R:R:M76 R:R:W288 3.49 1 Yes Yes 7 5 2 2
R:R:M76 R:R:Y291 5.99 1 Yes Yes 7 7 2 1
R:R:S79 R:R:Y291 5.09 0 No Yes 6 7 2 1
R:R:D102 R:R:Y291 11.49 1 No Yes 6 7 1 1
R:R:A154 R:R:I103 3.25 0 No No 7 4 2 1
R:R:S106 R:R:W261 3.71 0 No Yes 6 7 1 2
R:R:F185 R:R:P183 5.78 0 No No 2 4 1 2
R:R:P183 R:R:Y287 12.52 0 No No 4 5 2 2
R:R:F185 R:R:G190 4.52 0 No No 2 5 1 2
R:R:F194 R:R:F198 5.36 1 Yes Yes 5 7 2 2
R:R:F194 R:R:F265 8.57 1 Yes Yes 5 6 2 1
R:R:F198 R:R:W261 3.01 1 Yes Yes 7 7 2 2
R:R:F198 R:R:F265 11.79 1 Yes Yes 7 6 2 1
R:R:F264 R:R:W261 3.01 1 Yes Yes 6 7 1 2
R:R:F265 R:R:W261 4.01 1 Yes Yes 6 7 1 2
R:R:F264 R:R:F265 7.5 1 Yes Yes 6 6 1 1
R:R:F264 R:R:T268 3.89 1 Yes No 6 4 1 2
R:R:F264 R:R:L286 8.53 1 Yes No 6 5 1 2
R:R:F264 R:R:Y287 7.22 1 Yes No 6 5 1 2
R:R:W288 R:R:Y291 6.75 1 Yes Yes 5 7 2 1
R:R:F265 R:R:S197 2.64 1 Yes No 6 5 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8WC6_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.92
Number of Linked Nodes 246
Number of Links 270
Number of Hubs 30
Number of Links mediated by Hubs 125
Number of Communities 4
Number of Nodes involved in Communities 36
Number of Links involved in Communities 51
Path Summary
Number Of Nodes in MetaPath 52
Number Of Links MetaPath 51
Number of Shortest Paths 108783
Length Of Smallest Path 3
Average Path Length 20.5831
Length of Longest Path 37
Minimum Path Strength 1.39
Average Path Strength 4.9602
Maximum Path Strength 12.425
Minimum Path Correlation 0.7
Average Path Correlation 0.925278
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.125
Average % Of Corr. Nodes 35.4791
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 38.5791
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• D2 dopamine receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • molecular function regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • catalytic activity   • adenylate cyclase activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • D1 dopamine receptor binding   • molecular function activator activity   • enzyme activator activity   • cyclase activator activity   • adenylate cyclase activator activity   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • protein localization   • positive regulation of protein localization to cell periphery   • regulation of localization   • protein localization to cell periphery   • cellular localization   • regulation of protein localization   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • localization   • regulation of cellular localization   • regulation of protein localization to cell cortex   • cellular macromolecule localization   • macromolecule localization   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • cellular response to nitrogen compound   • cellular response to peptide hormone stimulus   • response to glucagon   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • homeostatic process   • adaptive thermogenesis   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • establishment of protein localization   • nitrogen compound transport   • regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • regulation of hormone secretion   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle
Gene OntologyCellular Component• midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle   • nuclear lumen   • cell periphery   • cell cortex   • cytoplasm   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • endomembrane system   • cilium   • plasma membrane bounded cell projection   • ciliary basal body   • cell projection   • Golgi apparatus subcompartment   • organelle subcompartment   • trans-Golgi network membrane   • trans-Golgi network   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • synapse   • cell junction   • G protein-coupled amine receptor activity   • molecular transducer activity   • trace-amine receptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • endoplasmic reticulum subcompartment   • nuclear outer membrane-endoplasmic reticulum membrane network   • endoplasmic reticulum   • endoplasmic reticulum membrane   • G-protein beta-subunit binding   • fibroblast proliferation
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodePEA
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodePEA
NamePhenethylamine
Synonymsβ-phenethylamine
Identifier
FormulaC8 H12 N
Molecular Weight122.188
SMILES
PubChem448751
Formal Charge1
Total Atoms21
Total Chiral Atoms0
Total Bonds21
Total Aromatic Bonds6

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ923Y8
Sequence
>8WC6_nogp_Chain_R
YSLMSLIIL ATLVGNLIV IISISHFKQ LHTPTNWLL HSMAIVDFL 
LGCLIMPCS MVRTVERCW YFGEILCKV HTSTDIMLS SASIFHLAF 
ISIDRYCAV CDPLRYKAK INISTILVM ILVSWSLPA VYAFGMIFL 
ELNLKGVEE LYRSQVSDG CSPFFSKVS GVLAFMTSF YIPGSVMLF 
VYYRIYFIA KGQARSINR TKAAKTLGI MVGVFLVCW CPFFLCTVL 
DPFLGYVIP PSLNDALYW FGYLNSALN PMVYAFFYP WFRRAL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9JKQAAmineTrace Amine ReceptorsTA1Homo sapiensMETH-Gs/β1/γ22.662024-10-16doi.org/10.1021/acs.jmedchem.4c01961
9JKQ (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensMETH-2.662024-10-16doi.org/10.1021/acs.jmedchem.4c01961
8ZSVAAmineTrace Amine ReceptorsTA1Mus musculusRO5263397-chim(NtGi1-Gs)/β1/γ22.962024-07-2410.1016/j.celrep.2024.114505
8ZSV (No Gprot) AAmineTrace Amine ReceptorsTA1Mus musculusRO5263397-2.962024-07-2410.1016/j.celrep.2024.114505
8ZSSAAmineTrace Amine ReceptorsTA1Homo sapiensRO5263397-chim(NtGi1-Gs)/β1/γ23.072024-07-2410.1016/j.celrep.2024.114505
8ZSS (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensRO5263397-3.072024-07-2410.1016/j.celrep.2024.114505
8ZSPAAmineTrace Amine ReceptorsTA1Homo sapiensLSD-chim(NtGi1L-Gs-CtGq)/β1/γ23.142024-07-2410.1016/j.celrep.2024.114505
8ZSP (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensLSD-3.142024-07-2410.1016/j.celrep.2024.114505
8ZSJAAmineTrace Amine ReceptorsTA1Homo sapiens--chim(NtGi1L-Gs-CtGq)/β1/γ22.82024-07-2410.1016/j.celrep.2024.114505
8ZSJ (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiens--2.82024-07-2410.1016/j.celrep.2024.114505
8UHBAAmineTrace Amine ReceptorsTA1Homo sapiensRO5256390-Gs/β1/γ23.352024-01-1010.1038/s41467-023-44601-4
8UHB (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensRO5256390-3.352024-01-1010.1038/s41467-023-44601-4
8WCCAAmineTrace Amine ReceptorsTA1Mus musculusCyclohexylammonium Ion--3.042023-12-2710.1016/j.cell.2023.10.014
8WCBAAmineTrace Amine ReceptorsTA1Mus musculusCyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ23.12023-12-2710.1016/j.cell.2023.10.014
8WCB (No Gprot) AAmineTrace Amine ReceptorsTA1Mus musculusCyclohexylammonium Ion-3.12023-12-2710.1016/j.cell.2023.10.014
8WC9AAmineTrace Amine ReceptorsTA1Mus musculusZH8651-chim(NtGi1-Gs-CtGq)/β1/γ23.22023-12-2710.1016/j.cell.2023.10.014
8WC9 (No Gprot) AAmineTrace Amine ReceptorsTA1Mus musculusZH8651-3.22023-12-2710.1016/j.cell.2023.10.014
8WCAAAmineTrace Amine ReceptorsTA1Homo sapiens2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ23.482023-12-2710.1016/j.cell.2023.10.014
8WCA (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiens2-Phenylethylamine-3.482023-12-2710.1016/j.cell.2023.10.014
8WC8AAmineTrace Amine ReceptorsTA1Homo sapiensZH8651-chim(NtGi1-Gs)/β1/γ22.92023-12-2710.1016/j.cell.2023.10.014
8WC8 (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensZH8651-2.92023-12-2710.1016/j.cell.2023.10.014
8WC7AAmineTrace Amine ReceptorsTA1Mus musculusZH8667-chim(NtGi1-Gs)/β1/γ23.12023-12-2710.1016/j.cell.2023.10.014
8WC7 (No Gprot) AAmineTrace Amine ReceptorsTA1Mus musculusZH8667-3.12023-12-2710.1016/j.cell.2023.10.014
8WC6AAmineTrace Amine ReceptorsTA1Mus musculus2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ23.22023-12-2710.1016/j.cell.2023.10.014
8WC6 (No Gprot) AAmineTrace Amine ReceptorsTA1Mus musculus2-Phenylethylamine-3.22023-12-2710.1016/j.cell.2023.10.014
8WC5AAmineTrace Amine ReceptorsTA1Mus musculusTetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ23.32023-12-2710.1016/j.cell.2023.10.014
8WC5 (No Gprot) AAmineTrace Amine ReceptorsTA1Mus musculusTetramethylammonium Ion-3.32023-12-2710.1016/j.cell.2023.10.014
8WC4AAmineTrace Amine ReceptorsTA1Mus musculusZH8651-chim(NtGi1-Gs)/β1/γ23.12023-12-2710.1016/j.cell.2023.10.014
8WC4 (No Gprot) AAmineTrace Amine ReceptorsTA1Mus musculusZH8651-3.12023-12-2710.1016/j.cell.2023.10.014
8WC3AAmineTrace Amine ReceptorsTA1Mus musculusSEP-363856-chim(NtGi1-Gs)/β1/γ232023-12-2710.1016/j.cell.2023.10.014
8WC3 (No Gprot) AAmineTrace Amine ReceptorsTA1Mus musculusSEP-363856-32023-12-2710.1016/j.cell.2023.10.014
8W8AAAmineTrace Amine ReceptorsTA1Homo sapiensRO5256390-chim(NtGi1L-Gs)/β1/γ22.82023-11-2210.1038/s41586-023-06775-1
8W8A (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensRO5256390-2.82023-11-2210.1038/s41586-023-06775-1
8W89AAmineTrace Amine ReceptorsTA1Homo sapiensPEA-chim(NtGi1L-Gs)/β1/γ232023-11-2210.1038/s41586-023-06775-1
8W89 (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensPEA-32023-11-2210.1038/s41586-023-06775-1
8W87AAmineTrace Amine ReceptorsTA1Homo sapiensMETH-chim(NtGi1L-Gs)/β1/γ22.82023-11-2210.1038/s41586-023-06775-1
8W87 (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensMETH-2.82023-11-2210.1038/s41586-023-06775-1
8W88AAmineTrace Amine ReceptorsTA1Homo sapiensSEP-363856-Gs/β1/γ22.62023-11-2210.1038/s41586-023-06775-1
8W88 (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensSEP-363856-2.62023-11-2210.1038/s41586-023-06775-1
8JSOAAmineTrace Amine ReceptorsTA1Homo sapiensAMPH-chim(NtGi1-Gs)/β1/γ23.42023-11-1510.1038/s41586-023-06804-z
8JSO (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensAMPH-3.42023-11-1510.1038/s41586-023-06804-z
8JLRAAmineTrace Amine ReceptorsTA1Homo sapiensA77636-chim(NtGi1-Gs)/β1/γ232023-11-1510.1038/s41586-023-06804-z
8JLR (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensA77636-32023-11-1510.1038/s41586-023-06804-z
8JLKAAmineTrace Amine ReceptorsTA1Mus musculusUlotaront-chim(NtGi1-Gs)/β1/γ23.222023-11-1510.1038/s41586-023-06804-z
8JLK (No Gprot) AAmineTrace Amine ReceptorsTA1Mus musculusUlotaront-3.222023-11-1510.1038/s41586-023-06804-z
8JLJAAmineTrace Amine ReceptorsTA1Mus musculusT1AM-chim(NtGi1-Gs)/β1/γ23.12023-11-1510.1038/s41586-023-06804-z
8JLJ (No Gprot) AAmineTrace Amine ReceptorsTA1Mus musculusT1AM-3.12023-11-1510.1038/s41586-023-06804-z
8JLQAAmineTrace Amine ReceptorsTA1Homo sapiensFenoldopam-Gs/β1/γ22.842023-11-1510.1038/s41586-023-06804-z
8JLQ (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensFenoldopam-2.842023-11-1510.1038/s41586-023-06804-z
8JLPAAmineTrace Amine ReceptorsTA1Homo sapiensRalmitaront-Gs/β1/γ23.232023-11-1510.1038/s41586-023-06804-z
8JLP (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensRalmitaront-3.232023-11-1510.1038/s41586-023-06804-z
8JLOAAmineTrace Amine ReceptorsTA1Homo sapiensUlotaront-Gs/β1/γ23.522023-11-1510.1038/s41586-023-06804-z
8JLO (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensUlotaront-3.522023-11-1510.1038/s41586-023-06804-z
8JLNAAmineTrace Amine ReceptorsTA1Homo sapiensT1AM-Gs/β1/γ23.242023-11-1510.1038/s41586-023-06804-z
8JLN (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensT1AM-3.242023-11-1510.1038/s41586-023-06804-z




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