psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D102	13.63	Yes	No	0	0	6
2	L:L:?1	R:R:I103	13.23	Yes	No	0	0	4
3	L:L:?1	R:R:S106	10.44	Yes	No	1	0	6
4	L:L:?1	R:R:F185	5.65	Yes	Yes	0	0	2
5	L:L:?1	R:R:W261	10.56	Yes	Yes	1	0	7
6	L:L:?1	R:R:F264	21.65	Yes	Yes	1	0	6
7	L:L:?1	R:R:F265	5.65	Yes	Yes	1	0	6
8	L:L:?1	R:R:Y287	16.31	Yes	Yes	1	0	5
9	R:R:Q22	R:R:V84	5.73	No	No	0	3	4
10	R:R:M80	R:R:Y26	4.79	No	Yes	0	6	4
11	R:R:V81	R:R:Y26	7.57	No	Yes	0	5	4
12	R:R:V84	R:R:Y26	20.19	No	Yes	0	4	4
13	R:R:E85	R:R:Y26	5.61	No	Yes	0	4	4
14	R:R:M29	R:R:M80	5.78	No	No	0	8	6
15	R:R:M29	R:R:T83	6.02	No	No	2	8	4
16	R:R:M29	R:R:W288	8.14	No	Yes	2	8	5
17	R:R:I32	R:R:W288	5.87	No	Yes	2	7	5
18	R:R:I32	R:R:Y291	22.97	No	Yes	2	7	7
19	R:R:I32	R:R:L292	7.14	No	No	0	7	6
20	R:R:I33	R:R:P77	5.08	No	No	0	5	8
21	R:R:I33	R:R:Y291	6.04	No	Yes	0	5	7
22	R:R:M76	R:R:T36	7.53	Yes	No	0	7	7
23	R:R:D68	R:R:N40	6.73	Yes	No	0	9	9
24	R:R:N40	R:R:P298	8.15	No	No	0	9	9
25	R:R:F69	R:R:L41	7.31	Yes	No	0	7	4
26	R:R:F303	R:R:I42	5.02	No	No	0	4	6
27	R:R:H62	R:R:I44	6.63	Yes	No	4	6	7
28	R:R:I44	R:R:I66	4.42	No	No	4	7	7
29	R:R:F50	R:R:S46	5.28	No	No	0	6	8
30	R:R:F308	R:R:S46	6.61	No	No	0	8	8
31	R:R:I47	R:R:N58	5.66	No	Yes	0	8	9
32	R:R:H62	R:R:I47	9.28	Yes	No	0	6	8
33	R:R:H62	R:R:S48	4.18	Yes	No	0	6	3
34	R:R:F50	R:R:Q52	8.2	No	No	0	6	6
35	R:R:H54	R:R:K51	5.24	No	No	0	7	6
36	R:R:L53	R:R:Q52	5.32	No	No	0	8	6
37	R:R:A311	R:R:L53	4.73	No	No	0	6	8
38	R:R:H54	R:R:W59	7.41	No	No	0	7	4
39	R:R:T55	R:R:T57	4.71	No	No	0	8	8
40	R:R:N58	R:R:T55	5.85	Yes	No	0	9	8
41	R:R:I136	R:R:P56	5.08	No	No	0	1	6
42	R:R:D119	R:R:T57	11.56	No	No	0	9	8
43	R:R:N58	R:R:W307	9.04	Yes	No	0	9	6
44	R:R:H62	R:R:W59	8.46	Yes	No	0	6	4
45	R:R:I116	R:R:L60	5.71	No	No	0	9	8
46	R:R:I139	R:R:L60	7.14	No	No	0	7	8
47	R:R:L60	R:R:M142	4.24	No	Yes	0	8	5
48	R:R:H62	R:R:I66	10.61	Yes	No	4	6	7
49	R:R:H112	R:R:S63	11.16	Yes	No	6	8	9
50	R:R:I143	R:R:S63	12.39	No	No	0	7	9
51	R:R:S63	R:R:W147	6.18	No	No	6	9	9
52	R:R:H112	R:R:M64	6.57	Yes	No	0	8	9
53	R:R:I116	R:R:M64	4.37	No	No	0	9	9
54	R:R:M64	R:R:N297	5.61	No	Yes	0	9	9
55	R:R:V67	R:R:W147	8.58	No	No	0	8	9
56	R:R:D68	R:R:S109	5.89	Yes	No	0	9	9
57	R:R:D68	R:R:S294	8.83	Yes	No	0	9	9
58	R:R:D68	R:R:N297	5.39	Yes	Yes	0	9	9
59	R:R:I75	R:R:L71	4.28	Yes	No	0	6	7
60	R:R:L105	R:R:L71	6.92	No	No	0	7	7
61	R:R:L71	R:R:S294	4.5	No	No	0	7	9
62	R:R:G72	R:R:M76	6.99	No	Yes	0	7	7
63	R:R:H98	R:R:I75	15.91	Yes	Yes	0	5	6
64	R:R:I75	R:R:T101	6.08	Yes	No	0	6	4
65	R:R:D102	R:R:I75	12.59	No	Yes	0	6	6
66	R:R:M76	R:R:W288	8.14	Yes	Yes	2	7	5
67	R:R:M76	R:R:Y291	23.95	Yes	Yes	2	7	7
68	R:R:C78	R:R:H98	7.37	No	Yes	0	4	5
69	R:R:R82	R:R:S79	10.54	No	No	0	5	6
70	R:R:R82	R:R:W88	5	No	Yes	3	5	7
71	R:R:H98	R:R:R82	4.51	Yes	No	3	5	5
72	R:R:D284	R:R:T83	11.56	No	No	0	3	4
73	R:R:T83	R:R:W288	4.85	No	Yes	2	4	5
74	R:R:F90	R:R:W88	20.04	No	Yes	0	7	7
75	R:R:C95	R:R:W88	10.45	No	Yes	3	9	7
76	R:R:H98	R:R:W88	5.29	Yes	Yes	3	5	7
77	R:R:C181	R:R:W88	18.28	No	Yes	3	9	7
78	R:R:F90	R:R:Y89	11.35	No	No	0	7	1
79	R:R:F90	R:R:L94	4.87	No	No	0	7	5
80	R:R:E92	R:R:K96	5.4	No	No	0	4	6
81	R:R:C181	R:R:C95	7.28	No	No	3	9	9
82	R:R:P183	R:R:T99	6.99	No	No	0	4	4
83	R:R:F155	R:R:S100	13.21	No	No	0	4	5
84	R:R:I158	R:R:S100	6.19	No	No	0	5	5
85	R:R:F159	R:R:S100	5.28	No	No	0	5	5
86	R:R:S106	R:R:W261	4.94	No	Yes	1	6	7
87	R:R:P150	R:R:S107	5.34	No	No	0	7	5
88	R:R:S107	R:R:S197	4.89	No	No	0	5	5
89	R:R:I110	R:R:W261	11.74	No	Yes	0	7	7
90	R:R:F111	R:R:L149	4.87	No	No	0	5	3
91	R:R:F111	R:R:P201	7.22	No	No	0	5	8
92	R:R:H112	R:R:S146	13.95	Yes	No	0	8	6
93	R:R:H112	R:R:W147	5.29	Yes	No	6	8	9
94	R:R:L113	R:R:N297	9.61	No	Yes	7	8	9
95	R:R:L113	R:R:Y301	8.21	No	Yes	7	8	9
96	R:R:F115	R:R:M142	19.9	No	Yes	0	6	5
97	R:R:F115	R:R:S146	7.93	No	No	0	6	6
98	R:R:M205	R:R:S117	7.67	Yes	No	8	8	8
99	R:R:S117	R:R:Y209	11.45	No	Yes	8	8	9
100	R:R:D119	R:R:Y130	9.2	No	Yes	5	9	7
101	R:R:D119	R:R:I134	7	No	No	5	9	7
102	R:R:R120	R:R:Y305	17.49	No	Yes	0	9	8
103	R:R:C125	R:R:Y121	13.44	No	No	0	6	8
104	R:R:V208	R:R:Y121	11.36	No	No	0	6	8
105	R:R:R211	R:R:Y121	13.38	No	No	0	4	8
106	R:R:C122	R:R:I134	6.55	No	No	0	4	7
107	R:R:A123	R:R:Y130	8.01	No	Yes	0	8	7
108	R:R:I215	R:R:V124	4.61	No	No	0	5	9
109	R:R:D126	R:R:R129	20.25	No	No	0	5	5
110	R:R:I134	R:R:Y130	9.67	No	Yes	5	7	7
111	R:R:N135	R:R:T138	5.85	No	No	0	8	5
112	R:R:M142	R:R:T138	4.52	Yes	No	0	5	5
113	R:R:L149	R:R:P150	4.93	No	No	0	3	7
114	R:R:M157	R:R:Y153	8.38	Yes	No	0	5	4
115	R:R:T196	R:R:Y153	9.99	No	No	0	5	4
116	R:R:I158	R:R:M157	4.37	No	Yes	0	5	5
117	R:R:L162	R:R:M157	4.24	No	Yes	0	4	5
118	R:R:F185	R:R:M157	4.98	Yes	Yes	0	2	5
119	R:R:I158	R:R:N163	9.91	No	No	0	5	4
120	R:R:L164	R:R:N163	8.24	No	No	0	3	4
121	R:R:L164	R:R:Y171	12.89	No	No	0	3	3
122	R:R:E168	R:R:G166	4.91	No	No	0	1	1
123	R:R:L170	R:R:Q174	14.64	No	No	0	4	2
124	R:R:V175	R:R:Y171	7.57	No	No	9	4	3
125	R:R:F184	R:R:Y171	5.16	No	No	9	2	3
126	R:R:R172	R:R:S176	7.91	No	No	0	2	3
127	R:R:F184	R:R:Q174	5.86	No	No	0	2	2
128	R:R:Q174	R:R:Y276	4.51	No	No	0	2	1
129	R:R:F184	R:R:V175	7.87	No	No	9	2	4
130	R:R:P183	R:R:Y287	9.74	No	Yes	0	4	5
131	R:R:F185	R:R:S189	5.28	Yes	No	0	2	6
132	R:R:F185	R:R:G190	4.52	Yes	No	0	2	5
133	R:R:S186	R:R:S189	6.52	No	No	0	6	6
134	R:R:F194	R:R:F198	6.43	Yes	Yes	1	5	7
135	R:R:F194	R:R:Y199	5.16	Yes	No	0	5	4
136	R:R:F194	R:R:F265	4.29	Yes	Yes	1	5	6
137	R:R:F194	R:R:L266	4.87	Yes	No	0	5	6
138	R:R:F194	R:R:V269	10.49	Yes	No	0	5	5
139	R:R:M195	R:R:Y199	7.18	No	No	0	4	4
140	R:R:F265	R:R:S197	5.28	Yes	No	0	6	5
141	R:R:F198	R:R:F257	4.29	Yes	Yes	0	7	9
142	R:R:C262	R:R:F198	4.19	No	Yes	0	5	7
143	R:R:F198	R:R:F265	17.15	Yes	Yes	1	7	6
144	R:R:S203	R:R:Y199	5.09	No	No	0	4	4
145	R:R:M205	R:R:Y209	5.99	Yes	Yes	8	8	9
146	R:R:F257	R:R:M205	8.71	Yes	Yes	0	9	8
147	R:R:F207	R:R:R211	7.48	No	No	0	5	4
148	R:R:L250	R:R:Y209	5.86	No	Yes	0	7	9
149	R:R:M253	R:R:Y209	9.58	No	Yes	0	8	9
150	R:R:V254	R:R:Y209	5.05	No	Yes	0	8	9
151	R:R:F214	R:R:Y210	14.44	No	No	0	3	3
152	R:R:K217	R:R:Y213	5.97	No	Yes	0	5	5
153	R:R:R225	R:R:T226	6.47	No	No	0	4	3
154	R:R:E243	R:R:K245	5.4	No	No	0	7	8
155	R:R:F304	R:R:K248	4.96	No	No	0	7	7
156	R:R:F304	R:R:T249	10.38	No	No	0	7	8
157	R:R:I252	R:R:V300	4.61	No	No	0	6	8
158	R:R:M253	R:R:Y301	5.99	No	Yes	0	8	9
159	R:R:M253	R:R:Y305	4.79	No	Yes	0	8	8
160	R:R:L296	R:R:V256	7.45	No	No	0	6	7
161	R:R:F257	R:R:W261	9.02	Yes	Yes	0	9	7
162	R:R:C260	R:R:N293	6.3	No	No	0	8	9
163	R:R:F264	R:R:W261	7.02	Yes	Yes	1	6	7
164	R:R:F265	R:R:W261	10.02	Yes	Yes	1	6	7
165	R:R:G290	R:R:W261	8.44	No	Yes	0	6	7
166	R:R:N293	R:R:W261	9.04	No	Yes	0	9	7
167	R:R:C262	R:R:L266	4.76	No	No	0	5	6
168	R:R:F289	R:R:P263	5.78	No	No	0	7	9
169	R:R:F264	R:R:F265	15	Yes	Yes	1	6	6
170	R:R:F264	R:R:T268	14.27	Yes	No	0	6	4
171	R:R:F264	R:R:Y287	7.22	Yes	Yes	1	6	5
172	R:R:D271	R:R:T268	4.34	No	No	0	3	4
173	R:R:D271	R:R:I278	4.2	No	Yes	0	3	1
174	R:R:P272	R:R:Y276	11.13	No	No	0	3	1
175	R:R:I278	R:R:L282	4.28	Yes	No	0	1	4
176	R:R:N283	R:R:Y287	6.98	No	Yes	0	2	5
177	R:R:W288	R:R:Y291	39.55	Yes	Yes	2	5	7
178	R:R:N293	R:R:N297	12.26	No	Yes	0	9	9
179	R:R:N297	R:R:Y301	4.65	Yes	Yes	7	9	9
180	R:R:V300	R:R:Y301	5.05	No	Yes	0	8	9
181	R:R:A302	R:R:F308	8.32	No	No	0	7	8
182	R:R:F303	R:R:F308	4.29	No	No	0	4	8
183	R:R:F304	R:R:Y305	5.16	No	Yes	0	7	8
184	R:R:W307	R:R:Y305	9.65	No	Yes	0	6	8
185	R:R:P306	R:R:R309	8.65	No	No	0	5	8
186	R:R:A193	R:R:F185	4.16	No	Yes	0	4	2
187	R:R:L105	R:R:L70	4.15	No	No	0	7	6
188	R:R:D126	R:R:K133	4.15	No	No	0	5	5
189	R:R:L292	R:R:L296	4.15	No	No	0	6	6
190	R:R:F214	R:R:Y213	4.13	No	Yes	0	3	5
191	R:R:L53	R:R:N58	4.12	No	Yes	0	8	9
192	R:R:E161	R:R:K96	4.05	No	No	0	5	6
193	R:R:R225	R:R:S222	3.95	No	No	0	4	4
194	R:R:F303	R:R:M299	3.73	No	No	0	4	6
195	R:R:K217	R:R:R221	3.71	No	No	0	5	6
196	R:R:F69	R:R:L37	3.65	Yes	No	0	7	6
197	R:R:F257	R:R:L258	3.65	Yes	No	0	9	5
198	R:R:F69	R:R:N40	3.62	Yes	No	0	7	9
199	R:R:L250	R:R:Y213	3.52	No	Yes	0	7	5
200	R:R:P56	R:R:T55	3.5	No	No	0	6	8
201	R:R:A65	R:R:V43	3.39	No	No	0	9	9
202	R:R:A108	R:R:V67	3.39	No	No	0	7	8
203	R:R:I200	R:R:P201	3.39	No	No	0	6	8
204	R:R:I278	R:R:P279	3.39	Yes	No	0	1	1
205	R:R:A295	R:R:T36	3.36	No	No	0	6	7
206	R:R:K187	R:R:P272	3.35	No	No	0	3	3
207	R:R:A65	R:R:I44	3.25	No	No	0	9	7
208	R:R:A154	R:R:I103	3.25	No	No	0	7	4
209	R:R:S117	R:R:V208	3.23	No	No	0	8	6
210	R:R:A151	R:R:M104	3.22	No	No	0	4	5
211	R:R:V256	R:R:V300	3.21	No	No	0	7	8
212	R:R:C73	R:R:L74	3.17	No	No	0	5	4
213	R:R:C267	R:R:L286	3.17	No	No	0	4	5
214	R:R:M80	R:R:S30	3.07	No	No	0	6	5
215	R:R:I42	R:R:V38	3.07	No	No	0	6	5
216	R:R:I118	R:R:V204	3.07	No	No	0	6	7
217	R:R:I212	R:R:V124	3.07	No	No	0	9	9
218	R:R:I212	R:R:V208	3.07	No	No	0	9	6
219	R:R:G218	R:R:R221	3	No	No	0	4	6
220	R:R:L34	R:R:V38	2.98	No	No	0	6	5
221	R:R:L94	R:R:V97	2.98	No	No	0	5	5
222	R:R:L149	R:R:V145	2.98	No	No	0	3	1
223	R:R:L192	R:R:V188	2.98	No	No	0	4	5
224	R:R:L270	R:R:V269	2.98	No	No	0	4	5
225	R:R:L274	R:R:V277	2.98	No	No	0	3	2
226	R:R:I118	R:R:M142	2.92	No	Yes	0	6	5
227	R:R:G275	R:R:Y276	2.9	No	No	0	1	1
228	R:R:I42	R:R:L312	2.85	No	No	0	6	7
229	R:R:I116	R:R:L61	2.85	No	No	0	9	8
230	R:R:I136	R:R:L140	2.85	No	No	0	1	2
231	R:R:L105	R:R:M104	2.83	No	No	0	7	5
232	R:R:C73	R:R:F69	2.79	No	Yes	0	5	7
233	R:R:L160	R:R:L162	2.77	No	No	0	5	4
234	R:R:M314	R:R:Q52	2.72	No	No	0	4	6
235	R:R:E161	R:R:L164	2.65	No	No	0	5	3
236	R:R:F273	R:R:V191	2.62	No	No	0	6	5
237	R:R:F159	R:R:I93	2.51	No	No	0	5	2
238	R:R:F264	R:R:L286	2.44	Yes	No	0	6	5
239	R:R:D177	R:R:R172	2.38	No	No	0	5	2
240	R:R:G179	R:R:G180	2.11	No	No	0	5	3
241	R:R:G39	R:R:P298	2.03	No	No	0	8	9
242	R:R:P279	R:R:P280	1.95	No	No	0	1	2
243	R:R:C262	R:R:P263	1.88	No	No	0	5	9
244	R:R:A114	R:R:P201	1.87	No	No	0	7	8
245	R:R:G180	R:R:V175	1.84	No	No	0	3	4
246	R:R:G255	R:R:V254	1.84	No	No	0	4	8
247	R:R:A295	R:R:A35	1.79	No	No	0	6	4
248	R:R:A216	R:R:A246	1.79	No	No	0	8	8
249	R:R:P183	R:R:S182	1.78	No	No	0	4	3
250	R:R:G202	R:R:M205	1.75	No	Yes	0	6	8
251	R:R:G166	R:R:K165	1.74	No	No	0	1	1
252	R:R:G156	R:R:L160	1.71	No	No	0	5	5
253	R:R:A247	R:R:T244	1.68	No	No	0	7	5
254	R:R:S186	R:R:V167	1.62	No	No	0	6	3
255	R:R:D126	R:R:P127	1.61	No	No	0	5	8
256	R:R:V141	R:R:V145	1.6	No	No	0	3	1
257	R:R:V191	R:R:V269	1.6	No	No	0	5	5
258	R:R:I278	R:R:V277	1.54	Yes	No	0	1	2
259	R:R:L170	R:R:S173	1.5	No	No	0	4	4
260	R:R:K217	R:R:T244	1.5	No	No	0	5	5
261	R:R:L25	R:R:V21	1.49	No	No	0	5	4
262	R:R:N135	R:R:S137	1.49	No	No	0	8	5
263	R:R:L206	R:R:V254	1.49	No	No	0	5	8
264	R:R:D177	R:R:S173	1.47	No	No	0	5	4
265	R:R:N227	R:R:T226	1.46	No	No	0	3	3
266	R:R:G91	R:R:W88	1.41	No	Yes	0	8	7
267	R:R:P306	R:R:Y305	1.39	No	Yes	0	5	8
268	R:R:A132	R:R:R129	1.38	No	No	0	3	5
269	R:R:I215	R:R:Q219	1.37	No	No	0	5	7
270	R:R:C87	R:R:Y89	1.34	No	No	0	4	1
271	R:R:H49	R:R:I45	1.33	No	No	0	5	5
272	R:R:A246	R:R:Y213	1.33	No	Yes	0	8	5
273	R:R:K131	R:R:Y130	1.19	No	Yes	0	4	7
274	R:R:L192	R:R:Y153	1.17	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	12.14	8	1	0
2	R:R:Y26	9.54	4	0	4
3	R:R:N58	6.1675	4	0	9
4	R:R:H62	7.832	5	4	6
5	R:R:D68	6.71	4	0	9
6	R:R:F69	4.3425	4	0	7
7	R:R:I75	9.715	4	0	6
8	R:R:M76	11.6525	4	2	7
9	R:R:W88	10.0783	6	3	7
10	R:R:H98	8.27	4	3	5
11	R:R:H112	9.2425	4	6	8
12	R:R:Y130	7.0175	4	5	7
13	R:R:M142	7.895	4	0	5
14	R:R:M157	5.4925	4	0	5
15	R:R:F185	4.918	5	0	2
16	R:R:F194	6.248	5	1	5
17	R:R:F198	8.015	4	1	7
18	R:R:M205	6.03	4	8	8
19	R:R:Y209	7.586	5	8	9
20	R:R:Y213	3.7375	4	0	5
21	R:R:F257	6.4175	4	0	9
22	R:R:W261	8.8475	8	1	7
23	R:R:F264	11.2667	6	1	6
24	R:R:F265	9.565	6	1	6
25	R:R:I278	3.3525	4	0	1
26	R:R:Y287	10.0625	4	1	5
27	R:R:W288	13.31	5	2	5
28	R:R:Y291	23.1275	4	2	7
29	R:R:N297	7.504	5	7	9
30	R:R:Y301	5.975	4	7	9
31	R:R:Y305	7.696	5	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W261	72.4098	10.56	Yes	Yes	1	0	7
2	R:R:N293	R:R:W261	76.5665	9.04	No	Yes	0	9	7
3	R:R:N293	R:R:N297	76.3811	12.26	No	Yes	0	9	9
4	R:R:N297	R:R:Y301	88.7661	4.65	Yes	Yes	7	9	9
5	R:R:V300	R:R:Y301	53.1021	5.05	No	Yes	0	8	9
6	R:R:V256	R:R:V300	50.0811	3.21	No	No	0	7	8
7	R:R:L296	R:R:V256	48.4895	7.45	No	No	0	6	7
8	R:R:L292	R:R:L296	46.8825	4.15	No	No	0	6	6
9	R:R:I32	R:R:L292	45.26	7.14	No	No	0	7	6
10	R:R:I32	R:R:W288	28.9732	5.87	No	Yes	2	7	5
11	R:R:M29	R:R:W288	15.0274	8.14	No	Yes	2	8	5
12	R:R:M29	R:R:M80	13.289	5.78	No	No	0	8	6
13	R:R:I32	R:R:Y291	14.6411	22.97	No	Yes	2	7	7
14	R:R:M76	R:R:T36	11.3498	7.53	Yes	No	0	7	7
15	R:R:D68	R:R:N297	34.5438	5.39	Yes	Yes	0	9	9
16	R:R:D68	R:R:N40	15.3828	6.73	Yes	No	0	9	9
17	R:R:F257	R:R:W261	52.3681	9.02	Yes	Yes	0	9	7
18	R:R:F257	R:R:M205	64.1582	8.71	Yes	Yes	0	9	8
19	R:R:M205	R:R:Y209	53.8206	5.99	Yes	Yes	8	8	9
20	R:R:M253	R:R:Y209	61.2995	9.58	No	Yes	0	8	9
21	R:R:M253	R:R:Y305	100	4.79	No	Yes	0	8	8
22	R:R:W307	R:R:Y305	86.4019	9.65	No	Yes	0	6	8
23	R:R:N58	R:R:W307	84.3004	9.04	Yes	No	0	9	6
24	R:R:L53	R:R:N58	35.1773	4.12	No	Yes	0	8	9
25	R:R:L53	R:R:Q52	30.3021	5.32	No	No	0	8	6
26	R:R:F50	R:R:Q52	25.6432	8.2	No	No	0	6	6
27	R:R:F50	R:R:S46	23.1476	5.28	No	No	0	6	8
28	R:R:F308	R:R:S46	20.6289	6.61	No	No	0	8	8
29	R:R:F303	R:R:F308	15.5605	4.29	No	No	0	4	8
30	R:R:M253	R:R:Y301	71.9694	5.99	No	Yes	0	8	9
31	R:R:F303	R:R:I42	10.4226	5.02	No	No	0	4	6
32	R:R:I47	R:R:N58	25.6432	5.66	No	Yes	0	8	9
33	R:R:H62	R:R:I47	23.1476	9.28	Yes	No	0	6	8
34	R:R:N58	R:R:T55	27.8452	5.85	Yes	No	0	9	8
35	R:R:T55	R:R:T57	17.832	4.71	No	No	0	8	8
36	R:R:D119	R:R:T57	15.2901	11.56	No	No	0	9	8
37	R:R:M64	R:R:N297	34.9301	5.61	No	Yes	0	9	9
38	R:R:I116	R:R:M64	18.6587	4.37	No	No	0	9	9
39	R:R:I116	R:R:L60	14.9965	5.71	No	No	0	9	8
40	R:R:L60	R:R:M142	11.3034	4.24	No	Yes	0	8	5
41	R:R:H112	R:R:M64	14.9656	6.57	Yes	No	0	8	9
42	L:L:?1	R:R:D102	19.8717	13.63	Yes	No	0	0	6
43	R:R:D102	R:R:I75	18.1102	12.59	No	Yes	0	6	6
44	R:R:I75	R:R:L71	17.5153	4.28	Yes	No	0	6	7
45	R:R:L71	R:R:S294	18.2492	4.5	No	No	0	7	9
46	R:R:H98	R:R:I75	22.9931	15.91	Yes	Yes	0	5	6
47	R:R:H98	R:R:W88	16.2018	5.29	Yes	Yes	3	5	7
48	L:L:?1	R:R:F185	75.0212	5.65	Yes	Yes	0	0	2
49	R:R:F185	R:R:M157	65.1626	4.98	Yes	Yes	0	2	5
50	R:R:I158	R:R:M157	50.9465	4.37	No	Yes	0	5	5
51	R:R:I158	R:R:N163	41.6828	9.91	No	No	0	5	4
52	R:R:L164	R:R:N163	39.7358	8.24	No	No	0	3	4
53	L:L:?1	R:R:Y287	10.0363	16.31	Yes	Yes	1	0	5
54	R:R:P183	R:R:Y287	10.8707	9.74	No	Yes	0	4	5
55	L:L:?1	R:R:F265	12.9723	5.65	Yes	Yes	1	0	6
56	R:R:F265	R:R:S197	27.9611	5.28	Yes	No	0	6	5
57	R:R:S107	R:R:S197	25.2337	4.89	No	No	0	5	5
58	R:R:P150	R:R:S107	22.4909	5.34	No	No	0	7	5
59	R:R:L149	R:R:P150	19.7327	4.93	No	No	0	3	7
60	R:R:F111	R:R:L149	11.3652	4.87	No	No	0	5	3
61	R:R:S117	R:R:V208	17.8243	3.23	No	No	0	8	6
62	R:R:L164	R:R:Y171	31.9787	12.89	No	No	0	3	3
63	R:R:F184	R:R:Y171	23.534	5.16	No	No	9	2	3
64	R:R:F184	R:R:Q174	21.7029	5.86	No	No	0	2	2
65	R:R:L170	R:R:Q174	11.0407	14.64	No	No	0	4	2
66	R:R:F194	R:R:F265	11.5352	4.29	Yes	Yes	1	5	6
67	R:R:F198	R:R:F265	11.4116	17.15	Yes	Yes	1	7	6
68	R:R:L250	R:R:Y209	21.4015	5.86	No	Yes	0	7	9
69	R:R:L250	R:R:Y213	19.5009	3.52	No	Yes	0	7	5
70	R:R:F264	R:R:T268	17.608	14.27	Yes	No	0	6	4
71	R:R:D271	R:R:T268	15.4601	4.34	No	No	0	3	4
72	R:R:D271	R:R:I278	13.2968	4.2	No	Yes	0	3	1
73	R:R:D68	R:R:S294	18.8596	8.83	Yes	No	0	9	9
74	R:R:F264	R:R:W261	22.7613	7.02	Yes	Yes	1	6	7
75	R:R:F265	R:R:W261	22.9004	10.02	Yes	Yes	1	6	7
76	R:R:F198	R:R:F257	17.3762	4.29	Yes	Yes	0	7	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D102	13.63	1	Yes	No	0	6	0	1
L:L:?1	R:R:I103	13.23	1	Yes	No	0	4	0	1
L:L:?1	R:R:S106	10.44	1	Yes	No	0	6	0	1
L:L:?1	R:R:F185	5.65	1	Yes	Yes	0	2	0	1
L:L:?1	R:R:W261	10.56	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F264	21.65	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F265	5.65	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:Y287	16.31	1	Yes	Yes	0	5	0	1
R:R:D102	R:R:I75	12.59	0	No	Yes	6	6	1	2
R:R:S106	R:R:W261	4.94	1	No	Yes	6	7	1	1
R:R:I110	R:R:W261	11.74	0	No	Yes	7	7	2	1
R:R:F185	R:R:M157	4.98	0	Yes	Yes	2	5	1	2
R:R:P183	R:R:Y287	9.74	0	No	Yes	4	5	2	1
R:R:F185	R:R:S189	5.28	0	Yes	No	2	6	1	2
R:R:F185	R:R:G190	4.52	0	Yes	No	2	5	1	2
R:R:F194	R:R:F198	6.43	1	Yes	Yes	5	7	2	2
R:R:F194	R:R:F265	4.29	1	Yes	Yes	5	6	2	1
R:R:F265	R:R:S197	5.28	1	Yes	No	6	5	1	2
R:R:F198	R:R:F257	4.29	1	Yes	Yes	7	9	2	2
R:R:F198	R:R:F265	17.15	1	Yes	Yes	7	6	2	1
R:R:F257	R:R:W261	9.02	0	Yes	Yes	9	7	2	1
R:R:F264	R:R:W261	7.02	1	Yes	Yes	6	7	1	1
R:R:F265	R:R:W261	10.02	1	Yes	Yes	6	7	1	1
R:R:G290	R:R:W261	8.44	0	No	Yes	6	7	2	1
R:R:N293	R:R:W261	9.04	0	No	Yes	9	7	2	1
R:R:F264	R:R:F265	15	1	Yes	Yes	6	6	1	1
R:R:F264	R:R:T268	14.27	1	Yes	No	6	4	1	2
R:R:F264	R:R:Y287	7.22	1	Yes	Yes	6	5	1	1
R:R:N283	R:R:Y287	6.98	0	No	Yes	2	5	2	1
R:R:A193	R:R:F185	4.16	0	No	Yes	4	2	2	1
R:R:A154	R:R:I103	3.25	0	No	No	7	4	2	1
R:R:F264	R:R:L286	2.44	1	Yes	No	6	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8ZSV_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	4.17
Number of Linked Nodes	259
Number of Links	274
Number of Hubs	31
Number of Links mediated by Hubs	121
Number of Communities	9
Number of Nodes involved in Communities	37
Number of Links involved in Communities	45

Path Summary
Number Of Nodes in MetaPath	77
Number Of Links MetaPath	76
Number of Shortest Paths	35388
Length Of Smallest Path	3
Average Path Length	12.4994
Length of Longest Path	31
Minimum Path Strength	1.485
Average Path Strength	7.09082
Maximum Path Strength	23.845
Minimum Path Correlation	0.7
Average Path Correlation	0.92436
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	51.2132
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.6055
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • D1 dopamine receptor binding • dopamine receptor binding • G protein activity • molecular function regulator activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • regulation of biological process • cell population proliferation • regulation of cellular process • positive regulation of cell population proliferation • biological regulation • positive regulation of biological process • positive regulation of neural precursor cell proliferation • regulation of cell population proliferation • cellular process • neural precursor cell proliferation • positive regulation of cellular process • regulation of neural precursor cell proliferation • reactive oxygen species metabolic process • regulation of superoxide metabolic process
Gene Ontology	Biological Process	• regulation of biological process • cell population proliferation • regulation of cellular process • positive regulation of cell population proliferation • biological regulation • positive regulation of biological process • positive regulation of neural precursor cell proliferation • regulation of cell population proliferation • cellular process • neural precursor cell proliferation • positive regulation of cellular process • regulation of neural precursor cell proliferation • reactive oxygen species metabolic process • regulation of superoxide metabolic process • positive regulation of reactive oxygen species metabolic process • superoxide metabolic process • positive regulation of metabolic process • superoxide anion generation • metabolic process • positive regulation of superoxide anion generation • regulation of superoxide anion generation • regulation of metabolic process • regulation of reactive oxygen species metabolic process • regulation of calcium ion transport • regulation of localization • transport • regulation of transport • regulation of monoatomic ion transport • establishment of localization • metal ion transport • calcium ion transport • localization • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • cellular response to stimulus • positive regulation of cell communication • positive regulation of signal transduction • response to stimulus • signaling • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • signal transduction • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • negative regulation of signaling • negative regulation of biological process • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • adenylate cyclase-activating adrenergic receptor signaling pathway • negative regulation of response to stimulus • adenylate cyclase-activating G protein-coupled receptor signaling pathway • negative regulation of signal transduction • negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell division • regulation of body fluid levels • multicellular organismal process • renal system process • system process • positive regulation of urine volume • regulation of urine volume • regulation of biological quality • regulation of vascular associated smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell proliferation • regulation of smooth muscle cell proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • muscle cell proliferation • vascular associated smooth muscle cell proliferation • cell-cell signaling • gamma-aminobutyric acid signaling pathway • purinergic nucleotide receptor signaling pathway • cell surface receptor signaling pathway • G protein-coupled purinergic receptor signaling pathway • G protein-coupled adenosine receptor signaling pathway • regulation of molecular function • negative regulation of lyase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • negative regulation of molecular function • negative regulation of catalytic activity • negative regulation of adenylate cyclase activity • regulated exocytosis • regulation of calcium ion-dependent exocytosis • negative regulation of transport • negative regulation of regulated secretory pathway • vesicle-mediated transport • regulation of regulated secretory pathway • secretion by cell • regulation of secretion by cell • negative regulation of secretion • negative regulation of exocytosis • negative regulation of secretion by cell • calcium-ion regulated exocytosis • secretion • negative regulation of calcium ion-dependent exocytosis • export from cell • regulation of vesicle-mediated transport • regulation of secretion • exocytosis • regulation of exocytosis • regulation of programmed cell death • negative regulation of apoptotic signaling pathway • negative regulation of programmed cell death • regulation of apoptotic process • cell death • apoptotic signaling pathway • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of apoptotic signaling pathway • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • locomotion • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • trans-synaptic signaling • modulation of chemical synaptic transmission • negative regulation of synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • cellular response to nitrogen compound • cellular response to acetylcholine • response to oxygen-containing compound • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to chemical • response to acetylcholine • response to nutrient levels • response to nutrient • developmental process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • cellular response to endogenous stimulus • response to hormone • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of multicellular organismal process • protein localization • establishment of protein localization • nitrogen compound transport • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • regulation of protein secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • hormone secretion • protein localization to extracellular region • peptide secretion • amide transport • signal release • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • midbody • cellular anatomical structure • membrane • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • neuronal dense core vesicle • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • cytosol • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • neuron to neuron synapse • synapse • cell junction • hippocampal mossy fiber to CA3 synapse • cell body • cilium • ciliary basal body • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • G protein-coupled amine receptor activity • molecular transducer activity • trace-amine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • electron transport chain • metabolic process • generation of precursor metabolites and energy • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • periplasmic space • endoplasmic reticulum subcompartment • nuclear outer membrane-endoplasmic reticulum membrane network • endoplasmic reticulum • endoplasmic reticulum membrane
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	A1D
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	A1D
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q923Y8
Sequence	>8ZSV_nogp_Chain_R E V Q A S L Y S L M S L I I L A T L V G N L I V I I S I S H F K Q L H T P T N W L L H S M A I V D F L L G C L I M P C S M V R T V E R C W Y F G E I L C K V H T S T D I M L S S A S I F H L A F I S I D R Y C A V C D P L R Y K A K I N I S T I L V M I L V S W S L P A V Y A F G M I F L E L N L K G V E E L Y R S Q V S D L G G C S P F F S K V S G V L A F M T S F Y I P G S V M L F V Y Y R I Y F I A K G Q A R S I N R T N E T K A A K T L G I M V G V F L V C W C P F F L C T V L D P F L G Y V I P P S L N D A L Y W F G Y L N S A L N P M V Y A F F Y P W F R R A L K M V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9JKQ	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	METH	-	Gs/β1/γ2	2.66	2024-10-16	doi.org/10.1021/acs.jmedchem.4c01961
	9JKQ (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	METH	-		2.66	2024-10-16	doi.org/10.1021/acs.jmedchem.4c01961
	8ZSV	A	Amine	Trace Amine Receptors	TA1	Mus musculus	RO5263397	-	chim(NtGi1-Gs)/β1/γ2	2.96	2024-07-24	10.1016/j.celrep.2024.114505
	8ZSV (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	RO5263397	-		2.96	2024-07-24	10.1016/j.celrep.2024.114505
	8ZSS	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5263397	-	chim(NtGi1-Gs)/β1/γ2	3.07	2024-07-24	10.1016/j.celrep.2024.114505
	8ZSS (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5263397	-		3.07	2024-07-24	10.1016/j.celrep.2024.114505
	8ZSP	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	LSD	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.14	2024-07-24	10.1016/j.celrep.2024.114505
	8ZSP (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	LSD	-		3.14	2024-07-24	10.1016/j.celrep.2024.114505
	8ZSJ	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	-	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-07-24	10.1016/j.celrep.2024.114505
	8ZSJ (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	-	-		2.8	2024-07-24	10.1016/j.celrep.2024.114505
	8UHB	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5256390	-	Gs/β1/γ2	3.35	2024-01-10	10.1038/s41467-023-44601-4
	8UHB (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5256390	-		3.35	2024-01-10	10.1038/s41467-023-44601-4
	8WCC	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Cyclohexylammonium Ion	-	-	3.04	2023-12-27	10.1016/j.cell.2023.10.014
	8WCB	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Cyclohexylammonium Ion	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2023-12-27	10.1016/j.cell.2023.10.014
	8WCB (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Cyclohexylammonium Ion	-		3.1	2023-12-27	10.1016/j.cell.2023.10.014
	8WC9	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8651	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.2	2023-12-27	10.1016/j.cell.2023.10.014
	8WC9 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8651	-		3.2	2023-12-27	10.1016/j.cell.2023.10.014
	8WCA	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	2-Phenylethylamine	-	chim(NtGi1-Gs)/β1/γ2	3.48	2023-12-27	10.1016/j.cell.2023.10.014
	8WCA (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	2-Phenylethylamine	-		3.48	2023-12-27	10.1016/j.cell.2023.10.014
	8WC8	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	ZH8651	-	chim(NtGi1-Gs)/β1/γ2	2.9	2023-12-27	10.1016/j.cell.2023.10.014
	8WC8 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	ZH8651	-		2.9	2023-12-27	10.1016/j.cell.2023.10.014
	8WC7	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8667	-	chim(NtGi1-Gs)/β1/γ2	3.1	2023-12-27	10.1016/j.cell.2023.10.014
	8WC7 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8667	-		3.1	2023-12-27	10.1016/j.cell.2023.10.014
	8WC6	A	Amine	Trace Amine Receptors	TA1	Mus musculus	2-Phenylethylamine	-	chim(NtGi1-Gs)/β1/γ2	3.2	2023-12-27	10.1016/j.cell.2023.10.014
	8WC6 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	2-Phenylethylamine	-		3.2	2023-12-27	10.1016/j.cell.2023.10.014
	8WC5	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Tetramethylammonium Ion	-	chim(NtGi1-Gs)/β1/γ2	3.3	2023-12-27	10.1016/j.cell.2023.10.014
	8WC5 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Tetramethylammonium Ion	-		3.3	2023-12-27	10.1016/j.cell.2023.10.014
	8WC4	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8651	-	chim(NtGi1-Gs)/β1/γ2	3.1	2023-12-27	10.1016/j.cell.2023.10.014
	8WC4 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8651	-		3.1	2023-12-27	10.1016/j.cell.2023.10.014
	8WC3	A	Amine	Trace Amine Receptors	TA1	Mus musculus	SEP-363856	-	chim(NtGi1-Gs)/β1/γ2	3	2023-12-27	10.1016/j.cell.2023.10.014
	8WC3 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	SEP-363856	-		3	2023-12-27	10.1016/j.cell.2023.10.014
	8W8A	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5256390	-	chim(NtGi1L-Gs)/β1/γ2	2.8	2023-11-22	10.1038/s41586-023-06775-1
	8W8A (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5256390	-		2.8	2023-11-22	10.1038/s41586-023-06775-1
	8W89	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	PEA	-	chim(NtGi1L-Gs)/β1/γ2	3	2023-11-22	10.1038/s41586-023-06775-1
	8W89 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	PEA	-		3	2023-11-22	10.1038/s41586-023-06775-1
	8W87	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	METH	-	chim(NtGi1L-Gs)/β1/γ2	2.8	2023-11-22	10.1038/s41586-023-06775-1
	8W87 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	METH	-		2.8	2023-11-22	10.1038/s41586-023-06775-1
	8W88	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	SEP-363856	-	Gs/β1/γ2	2.6	2023-11-22	10.1038/s41586-023-06775-1
	8W88 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	SEP-363856	-		2.6	2023-11-22	10.1038/s41586-023-06775-1
	8JSO	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	AMPH	-	chim(NtGi1-Gs)/β1/γ2	3.4	2023-11-15	10.1038/s41586-023-06804-z
	8JSO (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	AMPH	-		3.4	2023-11-15	10.1038/s41586-023-06804-z
	8JLR	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	A77636	-	chim(NtGi1-Gs)/β1/γ2	3	2023-11-15	10.1038/s41586-023-06804-z
	8JLR (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	A77636	-		3	2023-11-15	10.1038/s41586-023-06804-z
	8JLK	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Ulotaront	-	chim(NtGi1-Gs)/β1/γ2	3.22	2023-11-15	10.1038/s41586-023-06804-z
	8JLK (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Ulotaront	-		3.22	2023-11-15	10.1038/s41586-023-06804-z
	8JLJ	A	Amine	Trace Amine Receptors	TA1	Mus musculus	T1AM	-	chim(NtGi1-Gs)/β1/γ2	3.1	2023-11-15	10.1038/s41586-023-06804-z
	8JLJ (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	T1AM	-		3.1	2023-11-15	10.1038/s41586-023-06804-z
	8JLQ	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Fenoldopam	-	Gs/β1/γ2	2.84	2023-11-15	10.1038/s41586-023-06804-z
	8JLQ (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Fenoldopam	-		2.84	2023-11-15	10.1038/s41586-023-06804-z
	8JLP	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Ralmitaront	-	Gs/β1/γ2	3.23	2023-11-15	10.1038/s41586-023-06804-z
	8JLP (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Ralmitaront	-		3.23	2023-11-15	10.1038/s41586-023-06804-z
	8JLO	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Ulotaront	-	Gs/β1/γ2	3.52	2023-11-15	10.1038/s41586-023-06804-z
	8JLO (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Ulotaront	-		3.52	2023-11-15	10.1038/s41586-023-06804-z
	8JLN	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	T1AM	-	Gs/β1/γ2	3.24	2023-11-15	10.1038/s41586-023-06804-z
	8JLN (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	T1AM	-		3.24	2023-11-15	10.1038/s41586-023-06804-z

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