psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C178	R:R:C5	5.46	No	No	0	4	8
2	R:R:H175	R:R:N7	6.38	No	No	0	3	4
3	R:R:I11	R:R:I8	4.42	No	Yes	4	4	3
4	R:R:I8	R:R:R179	3.76	Yes	No	4	3	2
5	R:R:I11	R:R:R179	11.27	No	No	4	4	2
6	R:R:K15	R:R:S12	12.24	No	No	0	7	9
7	R:R:C13	R:R:C88	7.28	No	No	5	8	4
8	R:R:C13	R:R:Y90	5.38	No	No	5	8	1
9	R:R:K15	R:R:R179	9.9	No	No	0	7	2
10	R:R:N16	R:R:W18	10.17	No	No	0	3	1
11	R:R:E86	R:R:N16	9.2	Yes	No	0	4	3
12	R:R:V22	R:R:W18	4.9	No	No	0	3	1
13	R:R:N20	R:R:S19	4.47	No	No	7	5	2
14	R:R:D21	R:R:S19	10.31	No	No	7	4	2
15	R:R:D21	R:R:N20	5.39	No	No	7	4	5
16	R:R:E86	R:R:R23	5.82	Yes	No	0	4	4
17	R:R:M81	R:R:Y27	4.79	Yes	No	0	6	6
18	R:R:A85	R:R:Y27	5.34	No	No	6	5	6
19	R:R:E86	R:R:Y27	11.22	Yes	No	6	4	6
20	R:R:M30	R:R:M81	11.55	No	Yes	0	6	6
21	R:R:M30	R:R:W291	10.47	No	Yes	0	6	4
22	R:R:M81	R:R:V31	4.56	Yes	No	0	6	5
23	R:R:I33	R:R:W291	4.7	No	Yes	0	7	4
24	R:R:I33	R:R:L295	5.71	No	No	0	7	5
25	R:R:I34	R:R:M77	4.37	No	Yes	0	6	7
26	R:R:I34	R:R:M81	4.37	No	Yes	0	6	6
27	R:R:M77	R:R:T37	4.52	Yes	No	0	7	7
28	R:R:T298	R:R:T37	9.42	No	No	0	7	7
29	R:R:F70	R:R:L38	6.09	Yes	No	0	7	6
30	R:R:D69	R:R:N41	8.08	Yes	No	0	9	9
31	R:R:N41	R:R:P301	8.15	No	No	0	9	9
32	R:R:F70	R:R:L42	8.53	Yes	No	0	7	4
33	R:R:F306	R:R:I43	5.02	No	No	0	6	7
34	R:R:I43	R:R:L315	4.28	No	No	0	7	7
35	R:R:A66	R:R:V44	3.39	No	Yes	0	9	9
36	R:R:P301	R:R:V44	3.53	No	Yes	0	9	9
37	R:R:A305	R:R:V44	5.09	No	Yes	8	7	9
38	R:R:F311	R:R:V44	5.24	Yes	Yes	8	9	9
39	R:R:H63	R:R:I45	9.28	Yes	No	0	6	8
40	R:R:I45	R:R:T67	4.56	No	No	0	8	6
41	R:R:F311	R:R:S47	7.93	Yes	No	0	9	8
42	R:R:H63	R:R:I48	6.63	Yes	No	0	6	7
43	R:R:F311	R:R:I48	5.02	Yes	No	0	9	7
44	R:R:H63	R:R:S49	4.18	Yes	No	0	6	3
45	R:R:F51	R:R:H50	13.58	Yes	No	9	5	5
46	R:R:H50	R:R:M318	6.57	No	No	9	5	6
47	R:R:F51	R:R:Q53	4.68	Yes	No	0	5	5
48	R:R:F51	R:R:L54	4.87	Yes	No	0	5	8
49	R:R:A314	R:R:F51	6.93	No	Yes	0	7	5
50	R:R:F51	R:R:M318	4.98	Yes	No	9	5	6
51	R:R:L54	R:R:W310	3.42	No	Yes	0	8	6
52	R:R:H55	R:R:W60	6.35	No	No	0	8	4
53	R:R:P57	R:R:T56	3.5	No	No	0	6	8
54	R:R:N59	R:R:T56	10.24	No	No	0	9	8
55	R:R:I140	R:R:P57	3.39	No	No	0	7	6
56	R:R:N59	R:R:T58	4.39	No	No	0	9	8
57	R:R:D120	R:R:T58	7.23	No	No	2	9	8
58	R:R:T58	R:R:Y131	3.75	No	Yes	2	8	7
59	R:R:N59	R:R:W310	3.39	No	Yes	0	9	6
60	R:R:H63	R:R:W60	11.64	Yes	No	0	6	4
61	R:R:I117	R:R:L61	4.28	No	No	0	9	7
62	R:R:I140	R:R:L61	8.56	No	No	0	7	7
63	R:R:I144	R:R:L61	4.28	No	No	0	7	7
64	R:R:I144	R:R:S64	9.29	No	No	0	7	9
65	R:R:H113	R:R:M65	6.57	Yes	Yes	0	8	9
66	R:R:L114	R:R:M65	4.24	Yes	Yes	1	9	9
67	R:R:M65	R:R:N300	5.61	Yes	Yes	1	9	9
68	R:R:M65	R:R:Y304	4.79	Yes	Yes	1	9	9
69	R:R:T67	R:R:W148	3.64	No	No	0	6	9
70	R:R:D69	R:R:V68	4.38	Yes	No	0	9	8
71	R:R:A109	R:R:V68	3.39	No	No	0	7	8
72	R:R:V68	R:R:W148	9.81	No	No	0	8	9
73	R:R:D69	R:R:S110	5.89	Yes	No	1	9	9
74	R:R:D69	R:R:S297	8.83	Yes	No	0	9	9
75	R:R:D69	R:R:N300	8.08	Yes	Yes	1	9	9
76	R:R:C74	R:R:F70	6.98	No	Yes	0	4	7
77	R:R:L72	R:R:V76	5.96	Yes	Yes	0	7	7
78	R:R:L106	R:R:L72	4.15	No	Yes	0	6	7
79	R:R:L72	R:R:Y294	5.86	Yes	Yes	0	7	7
80	R:R:L72	R:R:S297	4.5	Yes	No	0	7	9
81	R:R:G73	R:R:M77	6.99	No	Yes	0	7	7
82	R:R:D103	R:R:V76	5.84	No	Yes	0	6	7
83	R:R:M77	R:R:W291	5.82	Yes	Yes	1	7	4
84	R:R:M77	R:R:Y294	16.76	Yes	Yes	1	7	7
85	R:R:F91	R:R:Y79	6.19	No	No	0	6	5
86	R:R:F95	R:R:Y79	13.41	No	No	0	5	5
87	R:R:H99	R:R:Y79	4.36	No	No	0	5	5
88	R:R:S80	R:R:Y294	8.9	No	Yes	0	6	7
89	R:R:F91	R:R:V82	7.87	No	No	0	6	5
90	R:R:R83	R:R:W89	10	No	Yes	0	4	7
91	R:R:D287	R:R:S84	5.89	No	No	0	3	5
92	R:R:S84	R:R:W291	6.18	No	Yes	0	5	4
93	R:R:A85	R:R:E86	4.53	No	Yes	6	5	4
94	R:R:H87	R:R:P283	9.15	No	No	0	4	1
95	R:R:C88	R:R:Y90	5.38	No	No	5	4	1
96	R:R:F91	R:R:W89	14.03	No	Yes	0	6	7
97	R:R:H99	R:R:W89	11.64	No	Yes	0	5	7
98	R:R:C182	R:R:W89	15.67	No	Yes	0	9	7
99	R:R:C96	R:R:E93	4.56	No	No	0	9	2
100	R:R:C182	R:R:C96	7.28	No	No	0	9	9
101	R:R:F160	R:R:I98	5.02	No	No	0	4	4
102	R:R:F156	R:R:S101	7.93	No	No	0	4	6
103	R:R:I159	R:R:S101	9.29	No	No	0	6	6
104	R:R:D103	R:R:Y294	9.2	No	Yes	1	6	7
105	L:L:?1	R:R:D103	18.93	Yes	No	1	0	6
106	L:L:?1	R:R:I104	8.38	Yes	No	0	0	4
107	R:R:F156	R:R:M105	3.73	No	No	0	4	5
108	R:R:S107	R:R:W264	4.94	No	Yes	1	6	8
109	L:L:?1	R:R:S107	12.13	Yes	No	1	0	6
110	R:R:P151	R:R:S108	5.34	No	No	0	8	5
111	R:R:S108	R:R:S198	4.89	No	No	0	5	6
112	R:R:N300	R:R:S110	4.47	Yes	No	1	9	9
113	R:R:F199	R:R:I111	3.77	Yes	No	1	8	8
114	R:R:I111	R:R:P202	5.08	No	Yes	0	8	9
115	R:R:F260	R:R:I111	6.28	Yes	No	1	9	8
116	R:R:V150	R:R:W112	6.13	Yes	No	0	4	6
117	R:R:P202	R:R:W112	6.76	Yes	No	0	9	6
118	R:R:H113	R:R:I144	3.98	Yes	No	0	8	7
119	R:R:H113	R:R:S147	9.76	Yes	No	0	8	7
120	R:R:H113	R:R:W148	4.23	Yes	No	0	8	9
121	R:R:F260	R:R:L114	3.65	Yes	Yes	1	9	9
122	R:R:L114	R:R:N300	5.49	Yes	Yes	1	9	9
123	R:R:L114	R:R:Y304	8.21	Yes	Yes	1	9	9
124	R:R:P202	R:R:S115	3.56	Yes	No	0	9	7
125	R:R:F116	R:R:M143	6.22	No	No	0	7	6
126	R:R:I117	R:R:R121	5.01	No	Yes	1	9	9
127	R:R:I117	R:R:Y304	6.04	No	Yes	1	9	9
128	R:R:M206	R:R:S118	6.13	Yes	No	1	9	8
129	R:R:S118	R:R:Y210	5.09	No	Yes	1	8	9
130	R:R:D120	R:R:Y131	8.05	No	Yes	2	9	7
131	R:R:D120	R:R:M135	5.54	No	Yes	2	9	7
132	R:R:R121	R:R:Y210	8.23	Yes	Yes	1	9	9
133	R:R:R121	R:R:Y304	6.17	Yes	Yes	1	9	9
134	R:R:R121	R:R:Y308	10.29	Yes	Yes	0	9	8
135	R:R:Y122	R:R:Y123	3.97	Yes	No	0	8	4
136	R:R:C126	R:R:Y122	13.44	No	Yes	0	6	8
137	R:R:V209	R:R:Y122	5.05	No	Yes	0	7	8
138	R:R:R212	R:R:Y122	6.17	No	Yes	0	5	8
139	R:R:K134	R:R:Y123	3.58	No	No	0	4	4
140	R:R:M135	R:R:Y123	5.99	Yes	No	0	7	4
141	R:R:A124	R:R:Y131	8.01	No	Yes	0	8	7
142	R:R:I213	R:R:V125	6.14	No	No	0	9	8
143	R:R:D127	R:R:R130	11.91	No	No	0	5	5
144	R:R:D127	R:R:K134	8.3	No	No	0	5	4
145	R:R:K132	R:R:Y131	4.78	No	Yes	0	4	7
146	R:R:M135	R:R:Y131	5.99	Yes	Yes	2	7	7
147	R:R:L138	R:R:N136	4.12	No	No	0	4	8
148	R:R:N136	R:R:V139	4.43	No	No	0	8	5
149	R:R:F145	R:R:S149	5.28	No	No	0	5	4
150	R:R:I146	R:R:V150	4.61	No	Yes	0	3	4
151	R:R:P151	R:R:V150	3.53	No	Yes	0	8	4
152	R:R:F154	R:R:L193	4.87	No	No	0	4	3
153	R:R:F154	R:R:T197	9.08	No	No	0	4	4
154	R:R:F156	R:R:F160	4.29	No	No	0	4	4
155	R:R:G157	R:R:L161	3.42	No	No	0	6	4
156	R:R:M158	R:R:N164	4.21	Yes	No	0	5	4
157	R:R:F186	R:R:M158	3.73	Yes	Yes	0	1	5
158	R:R:M158	R:R:S190	4.6	Yes	No	0	5	6
159	R:R:L161	R:R:L163	5.54	No	No	0	4	6
160	R:R:F165	R:R:N164	13.29	Yes	No	0	4	4
161	R:R:F165	R:R:Y173	24.76	Yes	No	3	4	2
162	R:R:F165	R:R:H177	6.79	Yes	Yes	3	4	4
163	R:R:F165	R:R:F185	5.36	Yes	No	0	4	1
164	R:R:E169	R:R:Y172	8.98	No	No	0	4	3
165	R:R:H175	R:R:I171	7.95	No	No	0	3	2
166	R:R:H278	R:R:Y172	4.36	No	No	0	1	3
167	R:R:K174	R:R:Y173	17.91	Yes	No	3	4	2
168	R:R:H177	R:R:Y173	23.96	Yes	No	3	4	2
169	R:R:H177	R:R:K174	3.93	Yes	Yes	3	4	4
170	R:R:F185	R:R:V176	26.22	No	No	0	1	3
171	L:L:?1	R:R:V184	4.38	Yes	No	0	0	4
172	R:R:F186	R:R:T194	6.49	Yes	No	0	1	5
173	L:L:?1	R:R:F186	3.58	Yes	Yes	0	0	1
174	R:R:F276	R:R:K188	4.96	No	No	0	5	3
175	R:R:F195	R:R:M196	3.73	Yes	No	0	5	5
176	R:R:F195	R:R:F199	8.57	Yes	Yes	1	5	8
177	R:R:F195	R:R:F268	4.29	Yes	Yes	1	5	7
178	R:R:F195	R:R:V272	14.42	Yes	No	0	5	6
179	R:R:M196	R:R:Y200	4.79	No	No	0	5	5
180	L:L:?1	R:R:S198	4.41	Yes	No	0	0	6
181	R:R:F199	R:R:F260	7.5	Yes	Yes	1	8	9
182	R:R:C265	R:R:F199	4.19	No	Yes	0	6	8
183	R:R:F199	R:R:F268	18.22	Yes	Yes	1	8	7
184	R:R:I201	R:R:P202	3.39	No	Yes	0	6	9
185	R:R:M206	R:R:Y210	3.59	Yes	Yes	1	9	9
186	R:R:M206	R:R:M257	4.33	Yes	No	0	9	8
187	R:R:F260	R:R:M206	8.71	Yes	Yes	1	9	9
188	R:R:L207	R:R:M257	4.24	No	No	0	5	8
189	R:R:C208	R:R:R212	5.57	No	No	0	4	5
190	R:R:L253	R:R:Y210	4.69	No	Yes	0	7	9
191	R:R:V256	R:R:Y210	3.79	No	Yes	0	8	9
192	R:R:L215	R:R:Y211	9.38	No	No	0	4	3
193	R:R:V250	R:R:Y214	5.05	No	No	0	8	5
194	R:R:K218	R:R:R247	3.71	No	Yes	0	6	5
195	R:R:I224	R:R:Q220	6.86	No	No	0	5	6
196	R:R:A221	R:R:R247	6.91	No	Yes	0	5	5
197	R:R:D226	R:R:R222	7.15	No	No	0	4	4
198	R:R:D226	R:R:S225	4.42	No	No	0	4	4
199	R:R:K245	R:R:K251	17.24	No	No	0	6	6
200	R:R:R247	R:R:V250	3.92	Yes	No	0	5	8
201	R:R:F307	R:R:T252	6.49	No	No	0	7	9
202	R:R:V256	R:R:Y304	5.05	No	Yes	0	8	9
203	R:R:L261	R:R:M257	4.24	No	No	0	6	8
204	R:R:F299	R:R:V259	3.93	No	No	0	6	6
205	R:R:F260	R:R:L261	3.65	Yes	No	0	9	6
206	R:R:C263	R:R:N296	6.3	No	No	0	8	9
207	R:R:F268	R:R:W264	9.02	Yes	Yes	1	7	8
208	R:R:G293	R:R:W264	4.22	No	Yes	0	7	8
209	R:R:N296	R:R:W264	16.95	No	Yes	0	9	8
210	L:L:?1	R:R:W264	10.04	Yes	Yes	1	0	8
211	R:R:F267	R:R:T271	9.08	No	No	0	5	5
212	L:L:?1	R:R:F267	14.31	Yes	No	0	0	5
213	L:L:?1	R:R:F268	5.37	Yes	Yes	1	0	7
214	R:R:C270	R:R:M273	4.86	No	No	0	4	4
215	R:R:C270	R:R:D274	4.67	No	Yes	0	4	2
216	R:R:D274	R:R:Y279	3.45	Yes	No	0	2	1
217	R:R:D274	R:R:I281	12.59	Yes	No	0	2	2
218	R:R:P282	R:R:Y279	6.95	No	No	0	1	1
219	R:R:I281	R:R:N286	14.16	No	No	0	2	4
220	R:R:I290	R:R:Y294	4.84	No	Yes	0	5	7
221	R:R:W291	R:R:Y294	10.61	Yes	Yes	1	4	7
222	L:L:?1	R:R:Y294	13.77	Yes	Yes	1	0	7
223	R:R:N296	R:R:N300	12.26	No	Yes	0	9	9
224	R:R:F299	R:R:T298	3.89	No	No	0	6	7
225	R:R:V303	R:R:Y304	3.79	No	Yes	0	8	9
226	R:R:A305	R:R:F311	5.55	No	Yes	8	7	9
227	R:R:F306	R:R:F311	7.5	No	Yes	0	6	9
228	R:R:W310	R:R:Y308	12.54	Yes	Yes	0	6	8
229	R:R:P309	R:R:R312	4.32	No	No	0	5	8
230	R:R:F311	R:R:W310	6.01	Yes	Yes	0	9	6
231	R:R:F320	R:R:Q325	8.2	No	No	0	4	6
232	R:R:D327	R:R:Q325	6.53	No	No	0	4	6
233	R:R:C331	R:R:S329	5.16	No	No	0	4	6
234	R:R:C265	R:R:I269	3.27	No	No	0	6	6
235	R:R:S187	R:R:S190	3.26	No	No	0	4	6
236	R:R:A155	R:R:I104	3.25	No	No	0	6	4
237	R:R:S12	R:R:V14	3.23	No	No	0	9	4
238	R:R:S25	R:R:V22	3.23	No	No	0	4	3
239	R:R:S149	R:R:V150	3.23	No	Yes	0	4	4
240	R:R:A152	R:R:M105	3.22	No	No	0	3	5
241	R:R:G180	R:R:H177	3.18	No	Yes	0	4	4
242	R:R:T102	R:R:V76	3.17	No	Yes	0	4	7
243	R:R:T100	R:R:V184	3.17	No	No	0	4	4
244	R:R:C270	R:R:L289	3.17	No	No	0	4	5
245	R:R:T298	R:R:T36	3.14	No	No	0	7	5
246	R:R:F307	R:R:Y308	3.09	No	Yes	0	7	8
247	R:R:I43	R:R:V39	3.07	No	No	0	7	5
248	R:R:I255	R:R:V303	3.07	No	No	0	6	8
249	R:R:F186	R:R:G191	3.01	Yes	No	0	1	4
250	R:R:F260	R:R:G203	3.01	Yes	No	0	9	6
251	R:R:L35	R:R:V39	2.98	No	No	0	5	5
252	R:R:L42	R:R:V46	2.98	No	No	0	4	4
253	R:R:L75	R:R:V76	2.98	No	Yes	0	5	7
254	R:R:L289	R:R:V288	2.98	No	No	0	5	4
255	R:R:L32	R:R:T36	2.95	No	No	0	5	5
256	R:R:I104	R:R:I159	2.94	No	No	0	4	6
257	R:R:I119	R:R:I205	2.94	No	No	0	6	6
258	R:R:D21	R:R:V22	2.92	No	No	0	4	3
259	R:R:I119	R:R:M143	2.92	No	No	0	6	6
260	R:R:I159	R:R:K97	2.91	No	No	0	6	6
261	R:R:I189	R:R:K188	2.91	No	No	0	4	3
262	R:R:K248	R:R:K251	2.87	No	No	0	8	6
263	R:R:I33	R:R:L29	2.85	No	No	0	7	5
264	R:R:G92	R:R:W89	2.81	No	Yes	0	8	7
265	R:R:L71	R:R:L75	2.77	No	No	0	7	5
266	R:R:L106	R:R:L71	2.77	No	No	0	6	7
267	R:R:H99	R:R:V76	2.77	No	Yes	0	5	7
268	R:R:E170	R:R:K174	2.7	No	Yes	0	3	4
269	R:R:F116	R:R:S147	2.64	No	No	0	7	7
270	R:R:F276	R:R:V192	2.62	No	No	0	5	5
271	R:R:F292	R:R:V288	2.62	No	No	0	7	4
272	R:R:F154	R:R:T194	2.59	No	No	0	4	5
273	R:R:D287	R:R:H87	2.52	No	No	0	3	4
274	R:R:F306	R:R:M302	2.49	No	No	0	6	6
275	R:R:F267	R:R:L289	2.44	No	No	0	5	5
276	R:R:L223	R:R:R222	2.43	No	No	0	4	4
277	R:R:F70	R:R:N41	2.42	Yes	No	0	7	9
278	R:R:I213	R:R:Y210	2.42	No	Yes	0	9	9
279	R:R:I280	R:R:Y279	2.42	No	No	0	1	1
280	R:R:L215	R:R:Y214	2.34	No	No	0	4	5
281	R:R:E162	R:R:F165	2.33	No	Yes	0	5	4
282	R:R:N17	R:R:W18	2.26	No	No	0	2	1
283	R:R:G180	R:R:G181	2.11	No	No	0	4	3
284	R:R:C265	R:R:P266	1.88	No	No	0	6	9
285	R:R:G40	R:R:V39	1.84	No	No	0	9	5
286	R:R:A217	R:R:A249	1.79	No	No	0	8	8
287	R:R:A168	R:R:S187	1.71	No	No	0	3	4
288	R:R:I34	R:R:P78	1.69	No	No	0	6	8
289	R:R:I137	R:R:P57	1.69	No	No	0	2	6
290	R:R:C126	R:R:I216	1.64	No	No	0	6	5
291	R:R:C141	R:R:I137	1.64	No	No	0	1	2
292	R:R:C141	R:R:I140	1.64	No	No	0	1	7
293	R:R:C263	R:R:I262	1.64	No	No	0	8	6
294	R:R:L285	R:R:P282	1.64	No	No	0	4	1
295	R:R:S25	R:R:S28	1.63	No	No	0	4	5
296	R:R:A305	R:R:I62	1.62	No	No	0	7	8
297	R:R:D127	R:R:P128	1.61	No	No	0	5	8
298	R:R:D274	R:R:P275	1.61	Yes	No	0	2	4
299	R:R:V192	R:R:V272	1.6	No	No	0	5	6
300	R:R:I205	R:R:S204	1.55	No	No	0	6	4
301	R:R:K326	R:R:S329	1.53	No	No	0	5	6
302	R:R:M135	R:R:V139	1.52	Yes	No	0	7	5
303	R:R:A168	R:R:E169	1.51	No	No	0	3	4
304	R:R:L26	R:R:S25	1.5	No	No	0	5	4
305	R:R:L285	R:R:T284	1.47	No	No	0	4	3
306	R:R:K313	R:R:K316	1.44	No	No	0	5	5
307	R:R:K316	R:R:M317	1.44	No	No	0	5	5
308	R:R:E246	R:R:V250	1.43	No	No	0	7	8
309	R:R:I8	R:R:N7	1.42	Yes	No	0	3	4
310	R:R:I8	R:R:N10	1.42	Yes	No	0	3	9
311	R:R:L163	R:R:M158	1.41	No	Yes	0	6	5
312	R:R:K166	R:R:L163	1.41	No	No	0	3	6
313	R:R:K322	R:R:L319	1.41	No	No	0	7	7
314	R:R:K174	R:R:N7	1.4	Yes	No	0	4	4
315	R:R:P309	R:R:Y308	1.39	No	Yes	0	5	8
316	R:R:A249	R:R:R247	1.38	No	Yes	0	8	5
317	R:R:L223	R:R:Q220	1.33	No	No	0	4	6
318	R:R:F51	R:R:M317	1.24	Yes	No	0	5	5
319	R:R:K313	R:R:R312	1.24	No	No	0	5	8
320	R:R:F276	R:R:L277	1.22	No	No	0	5	3
321	R:R:L253	R:R:Y214	1.17	No	No	0	7	5
322	R:R:F324	R:R:Q325	1.17	No	No	0	5	6
323	R:R:E219	R:R:R222	1.16	No	No	0	3	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:I8	2.755	4	4	3
2	R:R:V44	4.3125	4	8	9
3	R:R:F51	6.04667	6	9	5
4	R:R:H63	7.9325	4	0	6
5	R:R:M65	5.3025	4	1	9
6	R:R:D69	7.052	5	1	9
7	R:R:F70	6.005	4	0	7
8	R:R:L72	5.1175	4	0	7
9	R:R:V76	4.144	5	0	7
10	R:R:M77	7.692	5	1	7
11	R:R:M81	6.3175	4	0	6
12	R:R:E86	7.6925	4	6	4
13	R:R:W89	10.83	5	0	7
14	R:R:H113	6.135	4	0	8
15	R:R:L114	5.3975	4	1	9
16	R:R:R121	7.425	4	1	9
17	R:R:Y122	7.1575	4	0	8
18	R:R:Y131	6.116	5	2	7
19	R:R:M135	4.76	4	2	7
20	R:R:V150	4.375	4	0	4
21	R:R:M158	3.4875	4	0	5
22	R:R:F165	10.506	5	3	4
23	R:R:K174	6.485	4	3	4
24	R:R:H177	9.465	4	3	4
25	R:R:F186	4.2025	4	0	1
26	R:R:F195	7.7525	4	1	5
27	R:R:F199	8.45	5	1	8
28	R:R:P202	4.6975	4	0	9
29	R:R:M206	5.69	4	1	9
30	R:R:Y210	4.635	6	1	9
31	R:R:R247	3.98	4	0	5
32	R:R:F260	5.46667	6	1	9
33	R:R:W264	9.034	5	1	8
34	R:R:F268	9.225	4	1	7
35	R:R:D274	5.58	4	0	2
36	R:R:W291	7.556	5	1	4
37	R:R:Y294	9.99143	7	1	7
38	R:R:N300	7.182	5	1	9
39	R:R:Y304	5.675	6	1	9
40	R:R:Y308	6.8275	4	0	8
41	R:R:W310	6.34	4	0	6
42	R:R:F311	6.20833	6	8	9
43	L:L:?1	9.53	10	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I8	R:R:N7	27.8334	1.42	Yes	No	0	3	4
2	R:R:I8	R:R:R179	15.9334	3.76	Yes	No	4	3	2
3	R:R:K15	R:R:R179	11.9718	9.9	No	No	0	7	2
4	R:R:K174	R:R:N7	39.6503	1.4	Yes	No	0	4	4
5	R:R:K174	R:R:Y173	23.698	17.91	Yes	No	3	4	2
6	R:R:F165	R:R:Y173	25.6241	24.76	Yes	No	3	4	2
7	R:R:F165	R:R:N164	62.5968	13.29	Yes	No	0	4	4
8	R:R:M158	R:R:N164	64.4284	4.21	Yes	No	0	5	4
9	R:R:F186	R:R:M158	84.0779	3.73	Yes	Yes	0	1	5
10	L:L:?1	R:R:F186	94.3616	3.58	Yes	Yes	0	0	1
11	L:L:?1	R:R:Y294	56.3163	13.77	Yes	Yes	1	0	7
12	R:R:M77	R:R:Y294	40.1563	16.76	Yes	Yes	1	7	7
13	R:R:I34	R:R:M77	28.4036	4.37	No	Yes	0	6	7
14	R:R:I34	R:R:M81	25.322	4.37	No	Yes	0	6	6
15	R:R:M81	R:R:Y27	44.3559	4.79	Yes	No	0	6	6
16	R:R:E86	R:R:Y27	38.0641	11.22	Yes	No	6	4	6
17	R:R:E86	R:R:N16	31.8328	9.2	Yes	No	0	4	3
18	R:R:H177	R:R:K174	23.7887	3.93	Yes	Yes	3	4	4
19	R:R:F165	R:R:H177	29.5668	6.79	Yes	Yes	3	4	4
20	R:R:W291	R:R:Y294	38.6117	10.61	Yes	Yes	1	4	7
21	R:R:M30	R:R:W291	26.7986	10.47	No	Yes	0	6	4
22	R:R:M30	R:R:M81	25.2615	11.55	No	Yes	0	6	6
23	R:R:N16	R:R:W18	28.6831	10.17	No	No	0	3	1
24	R:R:V22	R:R:W18	22.3611	4.9	No	No	0	3	1
25	R:R:D69	R:R:N41	38.4833	8.08	Yes	No	0	9	9
26	R:R:D69	R:R:S297	53.0836	8.83	Yes	No	0	9	9
27	R:R:L72	R:R:S297	52.8419	4.5	Yes	No	0	7	9
28	R:R:L72	R:R:Y294	46.2669	5.86	Yes	Yes	0	7	7
29	R:R:D69	R:R:N300	33.2528	8.08	Yes	Yes	1	9	9
30	R:R:N296	R:R:N300	75.6335	12.26	No	Yes	0	9	9
31	R:R:N296	R:R:W264	74.5798	16.95	No	Yes	0	9	8
32	L:L:?1	R:R:W264	72.6462	10.04	Yes	Yes	1	0	8
33	R:R:N41	R:R:P301	30.8697	8.15	No	No	0	9	9
34	R:R:F306	R:R:F311	11.3373	7.5	No	Yes	0	6	9
35	R:R:F311	R:R:V44	26.0131	5.24	Yes	Yes	8	9	9
36	R:R:P301	R:R:V44	29.9634	3.53	No	Yes	0	9	9
37	R:R:M65	R:R:N300	50.0585	5.61	Yes	Yes	1	9	9
38	R:R:H113	R:R:M65	21.2886	6.57	Yes	Yes	0	8	9
39	R:R:D69	R:R:V68	14.7966	4.38	Yes	No	0	9	8
40	R:R:V68	R:R:W148	11.8811	9.81	No	No	0	8	9
41	R:R:F51	R:R:L54	13.8827	4.87	Yes	No	0	5	8
42	R:R:L54	R:R:W310	16.092	3.42	No	Yes	0	8	6
43	R:R:W310	R:R:Y308	80.1616	12.54	Yes	Yes	0	6	8
44	R:R:R121	R:R:Y308	100	10.29	Yes	Yes	0	9	8
45	R:R:R121	R:R:Y210	33.5813	8.23	Yes	Yes	1	9	9
46	R:R:M206	R:R:Y210	37.5505	3.59	Yes	Yes	1	9	9
47	R:R:F260	R:R:M206	39.4464	8.71	Yes	Yes	1	9	9
48	R:R:F199	R:R:F260	67.3817	7.5	Yes	Yes	1	8	9
49	R:R:F199	R:R:F268	63.1595	18.22	Yes	Yes	1	8	7
50	L:L:?1	R:R:F268	67.986	5.37	Yes	Yes	1	0	7
51	R:R:R121	R:R:Y304	74.9802	6.17	Yes	Yes	1	9	9
52	R:R:L114	R:R:Y304	65.822	8.21	Yes	Yes	1	9	9
53	R:R:F260	R:R:L114	37.6449	3.65	Yes	Yes	1	9	9
54	R:R:M65	R:R:Y304	37.5694	4.79	Yes	Yes	1	9	9
55	R:R:L114	R:R:N300	37.4901	5.49	Yes	Yes	1	9	9
56	R:R:H113	R:R:I144	11.4468	3.98	Yes	No	0	8	7
57	R:R:I140	R:R:L61	20.9638	8.56	No	No	0	7	7
58	R:R:I140	R:R:P57	10.5857	3.39	No	No	0	7	6
59	R:R:I117	R:R:Y304	17.444	6.04	No	Yes	1	9	9
60	R:R:I117	R:R:L61	16.0693	4.28	No	No	0	9	7
61	R:R:N59	R:R:W310	78.4093	3.39	No	Yes	0	9	6
62	R:R:N59	R:R:T58	75.9998	4.39	No	No	0	9	8
63	R:R:D120	R:R:T58	34.8012	7.23	No	No	2	9	8
64	R:R:T58	R:R:Y131	39.1518	3.75	No	Yes	2	8	7
65	L:L:?1	R:R:D103	10.0872	18.93	Yes	No	1	0	6
66	R:R:D103	R:R:V76	12.221	5.84	No	Yes	0	6	7
67	R:R:H99	R:R:V76	19.5362	2.77	No	Yes	0	5	7
68	R:R:H99	R:R:W89	12.1115	11.64	No	Yes	0	5	7
69	R:R:F156	R:R:S101	10.2874	7.93	No	No	0	4	6
70	R:R:I159	R:R:S101	12.323	9.29	No	No	0	6	6
71	R:R:I104	R:R:I159	16.311	2.94	No	No	0	4	6
72	L:L:?1	R:R:I104	20.2727	8.38	Yes	No	0	0	4
73	R:R:H113	R:R:S147	11.7565	9.76	Yes	No	0	8	7
74	R:R:D120	R:R:M135	32.6825	5.54	No	Yes	2	9	7
75	R:R:M135	R:R:Y131	32.7958	5.99	Yes	Yes	2	7	7
76	R:R:M135	R:R:Y123	48.1854	5.99	Yes	No	0	7	4
77	R:R:Y122	R:R:Y123	26.3945	3.97	Yes	No	0	8	4
78	R:R:K134	R:R:Y123	17.6253	3.58	No	No	0	4	4
79	R:R:D127	R:R:K134	13.2294	8.3	No	No	0	5	4
80	R:R:M135	R:R:V139	13.2294	1.52	Yes	No	0	7	5
81	R:R:M158	R:R:S190	12.323	4.6	Yes	No	0	5	6
82	R:R:S187	R:R:S190	10.2874	3.26	No	No	0	4	6
83	R:R:L253	R:R:Y210	16.7	4.69	No	Yes	0	7	9
84	R:R:L253	R:R:Y214	15.2158	1.17	No	No	0	7	5
85	R:R:V250	R:R:Y214	10.7179	5.05	No	No	0	8	5
86	L:L:?1	R:R:F267	32.2633	14.31	Yes	No	0	0	5
87	R:R:C270	R:R:L289	22.3876	3.17	No	No	0	4	5
88	R:R:F267	R:R:L289	28.3357	2.44	No	No	0	5	5
89	R:R:C270	R:R:D274	18.3844	4.67	No	Yes	0	4	2
90	R:R:D274	R:R:Y279	10.2874	3.45	Yes	No	0	2	1
91	R:R:P309	R:R:Y308	13.0896	1.39	No	Yes	0	5	8
92	R:R:F311	R:R:W310	24.5629	6.01	Yes	Yes	0	9	6
93	R:R:L72	R:R:V76	12.7195	5.96	Yes	Yes	0	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L72	R:R:V76	5.96	0	Yes	Yes	7	7	2	2
R:R:L72	R:R:Y294	5.86	0	Yes	Yes	7	7	2	1
R:R:D103	R:R:V76	5.84	1	No	Yes	6	7	1	2
R:R:M77	R:R:W291	5.82	1	Yes	Yes	7	4	2	2
R:R:M77	R:R:Y294	16.76	1	Yes	Yes	7	7	2	1
R:R:S80	R:R:Y294	8.9	0	No	Yes	6	7	2	1
R:R:D103	R:R:Y294	9.2	1	No	Yes	6	7	1	1
L:L:?1	R:R:D103	18.93	1	Yes	No	0	6	0	1
L:L:?1	R:R:I104	8.38	1	Yes	No	0	4	0	1
R:R:S107	R:R:W264	4.94	1	No	Yes	6	8	1	1
L:L:?1	R:R:S107	12.13	1	Yes	No	0	6	0	1
R:R:S108	R:R:S198	4.89	0	No	No	5	6	2	1
R:R:F186	R:R:M158	3.73	0	Yes	Yes	1	5	1	2
L:L:?1	R:R:V184	4.38	1	Yes	No	0	4	0	1
R:R:F186	R:R:T194	6.49	0	Yes	No	1	5	1	2
L:L:?1	R:R:F186	3.58	1	Yes	Yes	0	1	0	1
R:R:F195	R:R:F199	8.57	1	Yes	Yes	5	8	2	2
R:R:F195	R:R:F268	4.29	1	Yes	Yes	5	7	2	1
L:L:?1	R:R:S198	4.41	1	Yes	No	0	6	0	1
R:R:F199	R:R:F268	18.22	1	Yes	Yes	8	7	2	1
R:R:F268	R:R:W264	9.02	1	Yes	Yes	7	8	1	1
R:R:G293	R:R:W264	4.22	0	No	Yes	7	8	2	1
R:R:N296	R:R:W264	16.95	0	No	Yes	9	8	2	1
L:L:?1	R:R:W264	10.04	1	Yes	Yes	0	8	0	1
R:R:F267	R:R:T271	9.08	0	No	No	5	5	1	2
L:L:?1	R:R:F267	14.31	1	Yes	No	0	5	0	1
L:L:?1	R:R:F268	5.37	1	Yes	Yes	0	7	0	1
R:R:I290	R:R:Y294	4.84	0	No	Yes	5	7	2	1
R:R:W291	R:R:Y294	10.61	1	Yes	Yes	4	7	2	1
L:L:?1	R:R:Y294	13.77	1	Yes	Yes	0	7	0	1
R:R:A155	R:R:I104	3.25	0	No	No	6	4	2	1
R:R:T100	R:R:V184	3.17	0	No	No	4	4	2	1
R:R:F186	R:R:G191	3.01	0	Yes	No	1	4	1	2
R:R:I104	R:R:I159	2.94	0	No	No	4	6	1	2
R:R:F267	R:R:L289	2.44	0	No	No	5	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8UHB_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.39
Number of Linked Nodes	293
Number of Links	323
Number of Hubs	43
Number of Links mediated by Hubs	167
Number of Communities	9
Number of Nodes involved in Communities	49
Number of Links involved in Communities	62

Path Summary
Number Of Nodes in MetaPath	94
Number Of Links MetaPath	93
Number of Shortest Paths	81169
Length Of Smallest Path	3
Average Path Length	13.8138
Length of Longest Path	29
Minimum Path Strength	1.34
Average Path Strength	7.06416
Maximum Path Strength	21.335
Minimum Path Correlation	0.7
Average Path Correlation	0.96885
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	72.3651
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	53.9284
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • amide binding • amyloid-beta binding • peptide binding • protein binding • enzyme binding • adenylate cyclase binding • G protein-coupled amine receptor activity • molecular transducer activity • beta2-adrenergic receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • beta-adrenergic receptor activity • adrenergic receptor activity • protein-containing complex binding • monoatomic cation transmembrane transporter activity • channel regulator activity • ion channel regulator activity • monoatomic ion channel activity • potassium ion transmembrane transporter activity • potassium channel activity • potassium channel regulator activity • monoatomic cation channel activity • passive transmembrane transporter activity • inorganic molecular entity transmembrane transporter activity • channel activity • molecular function regulator activity • inorganic cation transmembrane transporter activity • monoatomic ion transmembrane transporter activity • transporter activity • transporter regulator activity • metal ion transmembrane transporter activity • transmembrane transporter activity • identical protein binding • protein homodimerization activity • protein dimerization activity • catecholamine binding • norepinephrine binding • trace-amine receptor activity • electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • multicellular organismal process • response to nutrient levels • response to stimulus • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • response to dietary excess • diet induced thermogenesis • energy homeostasis • response to stress
Gene Ontology	Biological Process	• electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • multicellular organismal process • response to nutrient levels • response to stimulus • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • response to dietary excess • diet induced thermogenesis • energy homeostasis • response to stress • response to abiotic stimulus • response to cold • response to temperature stimulus • regulation of developmental process • positive regulation of biological process • regulation of biomineral tissue development • regulation of bone mineralization • positive regulation of ossification • positive regulation of developmental process • multicellular organism development • positive regulation of biomineral tissue development • ossification • anatomical structure development • biomineral tissue development • regulation of multicellular organismal process • developmental process • regulation of multicellular organismal development • regulation of biological process • bone mineralization • animal organ development • biological regulation • tissue development • positive regulation of bone mineralization • positive regulation of multicellular organismal process • regulation of ossification • regulation of multicellular organism growth • regulation of growth • regulation of developmental growth • negative regulation of multicellular organism growth • developmental growth • negative regulation of developmental process • growth • negative regulation of biological process • multicellular organism growth • negative regulation of developmental growth • negative regulation of growth • negative regulation of multicellular organismal process • cellular response to stimulus • adenylate cyclase-activating adrenergic receptor signaling pathway • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adrenergic receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • fat cell differentiation • cellular developmental process • brown fat cell differentiation • cell differentiation • system process • regulation of system process • muscle contraction • muscle system process • regulation of muscle system process • negative regulation of muscle contraction • smooth muscle contraction • regulation of smooth muscle contraction • regulation of muscle contraction • negative regulation of smooth muscle contraction • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • positive regulation of metabolic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • positive regulation of cellular process • regulation of RNA biosynthetic process • regulation of biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of nucleobase-containing compound metabolic process • primary metabolic process • regulation of macromolecule metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • regulation of gene expression • biosynthetic process • positive regulation of RNA biosynthetic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of DNA-templated transcription • regulation of metabolic process • tissue remodeling • bone remodeling • anatomical structure homeostasis • tissue homeostasis • bone resorption • positive regulation of phosphorylation • regulation of catalytic activity • regulation of transferase activity • positive regulation of phosphate metabolic process • cell surface receptor protein tyrosine kinase signaling pathway • cellular component biogenesis • cellular component assembly • regulation of phosphate metabolic process • phosphate-containing compound metabolic process • phosphorus metabolic process • protein modification process • positive regulation of protein phosphorylation • activation of transmembrane receptor protein tyrosine kinase activity • protein phosphorylation • positive regulation of phosphorus metabolic process • phosphorylation • regulation of protein metabolic process • regulation of molecular function • positive regulation of kinase activity • regulation of kinase activity • activation of protein kinase activity • macromolecule modification • regulation of phosphorus metabolic process • regulation of protein modification process • regulation of protein phosphorylation • positive regulation of protein metabolic process • cellular component organization • positive regulation of molecular function • positive regulation of protein modification process • protein-containing complex assembly • cellular component organization or biogenesis • protein metabolic process • positive regulation of protein kinase activity • enzyme-linked receptor protein signaling pathway • positive regulation of transferase activity • cell surface receptor signaling pathway • protein-containing complex organization • positive regulation of catalytic activity • regulation of protein kinase activity • regulation of phosphorylation • localization • import into cell • transport • receptor-mediated endocytosis • endocytosis • establishment of localization • vesicle-mediated transport • cellular localization • endosome to lysosome transport • intracellular transport • lysosomal transport • establishment of localization in cell • vacuolar transport • positive regulation of organelle organization • catabolic process • regulation of cellular component organization • positive regulation of cellular component organization • regulation of autophagosome maturation • macroautophagy • autophagy • protein-containing complex disassembly • regulation of autophagy • regulation of protein-containing complex disassembly • autophagosome maturation • positive regulation of macroautophagy • process utilizing autophagic mechanism • positive regulation of protein-containing complex disassembly • cellular component disassembly • positive regulation of autophagy • regulation of catabolic process • positive regulation of autophagosome maturation • regulation of organelle organization • positive regulation of catabolic process • organelle organization • regulation of macroautophagy • lipophagy • positive regulation of lipophagy • regulation of lipophagy • response to psychosocial stress • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • positive regulation of signaling • ligand-gated ion channel signaling pathway • ionotropic glutamate receptor signaling pathway • glutamate receptor signaling pathway • AMPA selective glutamate receptor signaling pathway • regulation of tube diameter • regulation of systemic arterial blood pressure mediated by a chemical signal • regulation of blood pressure • regulation of tube size • norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure • negative regulation of blood pressure • regulation of systemic arterial blood pressure by norepinephrine-epinephrine • regulation of systemic arterial blood pressure • circulatory system process • negative regulation of systemic arterial blood pressure • vascular process in circulatory system • regulation of biological quality • blood vessel diameter maintenance • vasodilation • blood circulation • regulation of anatomical structure size • negative regulation of signaling • negative regulation of response to stimulus • negative regulation of signal transduction • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • positive regulation of cAMP/PKA signal transduction • cAMP/PKA signal transduction • regulation of cAMP/PKA signal transduction • cellular response to nitrogen compound • response to oxygen-containing compound • response to nitrogen compound • cellular response to amyloid-beta • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to chemical • response to amyloid-beta • regulation of localization • regulation of transport • regulation of monoatomic ion transport • regulation of sodium ion transport • metal ion transport • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • sodium ion transport • heat generation • regulation of postsynaptic membrane potential • modulation of chemical synaptic transmission • positive regulation of excitatory postsynaptic potential • chemical synaptic transmission, postsynaptic • synaptic signaling • modulation of excitatory postsynaptic potential • mini excitatory postsynaptic potential • trans-synaptic signaling • nervous system process • cell-cell signaling • chemical synaptic transmission • regulation of nervous system process • regulation of mini excitatory postsynaptic potential • positive regulation of mini excitatory postsynaptic potential • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • excitatory postsynaptic potential • regulation of membrane potential • phospholipase C-activating G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cellular anatomical structure • periplasmic space • membrane • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle
Gene Ontology	Cellular Component	• cellular anatomical structure • periplasmic space • membrane • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • neuronal dense core vesicle • bounding membrane of organelle • vesicle membrane • clathrin-coated vesicle • endocytic vesicle membrane • coated vesicle • endocytic vesicle • clathrin-coated vesicle membrane • clathrin-coated endocytic vesicle membrane • clathrin-coated endocytic vesicle • cytoplasmic vesicle membrane • coated vesicle membrane • organelle membrane • protein-containing complex • receptor complex • intercellular bridge • Golgi apparatus • endosome membrane • endosome • intracellular membraneless organelle • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • microtubule organizing center • cytoskeleton • membraneless organelle • microtubule cytoskeleton • cell periphery • apical part of cell • plasma membrane • plasma membrane region • apical plasma membrane • mitotic spindle • spindle • lytic vacuole • vacuole • lysosome • early endosome • nucleus • organelle subcompartment • endoplasmic reticulum subcompartment • nuclear outer membrane-endoplasmic reticulum membrane network • endoplasmic reticulum • endoplasmic reticulum membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • cytosol • vacuolar membrane • lytic vacuole membrane • lysosomal membrane • synapse • cell junction • mu-type opioid receptor binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • beta-2 adrenergic receptor binding • adrenergic receptor binding • cytoskeletal protein binding • tubulin binding • alpha-tubulin binding • G-protein alpha-subunit binding • D1 dopamine receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • cation binding • ion binding • metal ion binding • small molecule binding • insulin-like growth factor receptor binding • protein domain specific binding • ionotropic glutamate receptor binding • glutamate receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • G-protein beta-subunit binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • G protein activity • skeletal system development • connective tissue development • tissue development • cartilage development • response to xenobiotic stimulus • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • cognition • endochondral ossification • replacement ossification • endochondral bone morphogenesis • anatomical structure morphogenesis • ossification • skeletal system morphogenesis • animal organ morphogenesis • bone morphogenesis • embryonic hindlimb morphogenesis • limb development • appendage development • embryonic limb morphogenesis • embryonic morphogenesis • hindlimb morphogenesis • embryonic appendage morphogenesis • embryo development • appendage morphogenesis • limb morphogenesis • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • multicellular organism growth • developmental growth • growth • response to parathyroid hormone • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • ectodermal placode formation • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • regulation of signaling • regulation of signal transduction • regulation of response to stimulus • regulation of cell communication • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • embryonic organ morphogenesis • embryonic cranial skeleton morphogenesis • chordate embryonic development • embryo development ending in birth or egg hatching • cranial skeletal system development • embryonic skeletal system development • embryonic organ development • embryonic skeletal system morphogenesis • energy derivation by oxidation of organic compounds • energy reserve metabolic process • metabolic process • generation of precursor metabolites and energy • regulation of parathyroid hormone secretion • regulation of localization • regulation of hormone secretion • transport • regulation of system process • hormone secretion • localization • regulation of secretion by cell • secretion by cell • signal release • regulation of multicellular organismal process • regulation of transport • secretion • regulation of hormone levels • export from cell • parathyroid hormone secretion • establishment of localization • regulation of secretion • endocrine process • endocrine hormone secretion • hormone transport • regulation of endocrine process • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • post-embryonic animal morphogenesis • post-embryonic development • post-embryonic body morphogenesis • body morphogenesis • homeostatic process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of metabolic process • serotonin receptor signaling pathway • adenylate cyclase-activating serotonin receptor signaling pathway • regulation of osteoblast differentiation • cellular developmental process • regulation of developmental process • regulation of cell differentiation • osteoblast differentiation • positive regulation of developmental process • positive regulation of osteoblast differentiation • positive regulation of cell differentiation • cell differentiation • anatomical structure homeostasis • tissue homeostasis • regulation of monoatomic ion transport • regulation of sodium ion transport • metal ion transport • positive regulation of sodium ion transport • positive regulation of transport • positive regulation of monoatomic ion transport • monoatomic ion transport • monoatomic cation transport • regulation of metal ion transport • sodium ion transport • RNA metabolic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • regulation of biosynthetic process • primary metabolic process • regulation of macromolecule metabolic process • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • regulation of gene expression • biosynthetic process • regulation of macromolecule biosynthetic process • regulation of DNA-templated transcription • macromolecule metabolic process • sexual reproduction • reproductive process • cell development • cellular process involved in reproduction in multicellular organism • developmental process involved in reproduction • gamete generation • cellular component organization • chromatin organization • chromatin remodeling • cellular component organization or biogenesis • epigenetic programming of gene expression • epigenetic regulation of gene expression • multicellular organismal reproductive process • genomic imprinting • germ cell development • protein localization • positive regulation of cell communication • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • cellular macromolecule localization • positive regulation of insulin secretion • regulation of peptide hormone secretion • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • regulation of protein secretion • positive regulation of protein localization • cellular localization • regulation of protein localization • regulation of peptide secretion • positive regulation of secretion by cell • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • positive regulation of hormone secretion • positive regulation of secretion • amide transport • positive regulation of peptide secretion • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • positive regulation of protein secretion • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • insulin secretion • positive regulation of signaling • circulatory system process • regulation of blood pressure • negative regulation of blood pressure • blood circulation • myeloid leukocyte differentiation • regulation of leukocyte differentiation • positive regulation of osteoclast differentiation • regulation of cell development • regulation of osteoclast differentiation • positive regulation of hemopoiesis • osteoclast differentiation • regulation of immune system process • positive regulation of immune system process • regulation of multicellular organismal development • hemopoiesis • regulation of myeloid cell differentiation • positive regulation of cell development • regulation of myeloid leukocyte differentiation • positive regulation of myeloid leukocyte differentiation • myeloid cell differentiation • immune system process • positive regulation of myeloid cell differentiation • regulation of hemopoiesis • positive regulation of leukocyte differentiation • leukocyte differentiation • sarcolemma • somatodendritic compartment • dendrite • dendritic tree • recycling endosome • ruffle • cell leading edge • perinuclear region of cytoplasm • cell body • neuronal cell body • Golgi apparatus subcompartment • trans-Golgi network membrane • trans-Golgi network • transport vesicle • COPI-coated Golgi to ER transport vesicle • COPI-coated vesicle • Golgi-associated vesicle • fibroblast proliferation
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	WV8
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	WV8
Name	(2R,4S)-4-[(2S)-2-phenylbutyl]-1,3-oxazolidin-2-amine
Synonyms
Identifier
Formula	C13 H18 N2 O
Molecular Weight	218.295
SMILES
PubChem	24963286
Formal Charge	0
Total Atoms	34
Total Chiral Atoms	2
Total Bonds	35
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q96RJ0
Sequence	>8UHB_nogp_Chain_R C H N I I N I S C V K N N W S N D V R A S L Y S L M V L I I L T T L V G N L I V I V S I S H F K Q L H T P T N W L I H S M A T V D F L L G C L V M P Y S M V R S A E H C W Y F G E V F C K I H T S T D I M L S S A S I W H L S F I S I D R Y Y A V C D P L R Y K A K M N I L V I C V M I F I S W S V P A V F A F G M I F L E L N F K G A E E I Y Y K H V H C R G G C S V F F S K I S G V L T F M T S F Y I P G S I M L C V Y Y R I Y L I A K E Q A R L I S D A N Q K S K E R K A V K T L G I V M G V F L I C W C P F F I C T V M D P F L H Y I I P P T L N D V L I W F G Y L N S T F N P M V Y A F F Y P W F R K A L K M M L F G K I F Q K D S S R C K L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9JKQ	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	METH	-	Gs/β1/γ2	2.66	2024-10-16	doi.org/10.1021/acs.jmedchem.4c01961
	9JKQ (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	METH	-		2.66	2024-10-16	doi.org/10.1021/acs.jmedchem.4c01961
	8ZSV	A	Amine	Trace Amine Receptors	TA1	Mus musculus	RO5263397	-	chim(NtGi1-Gs)/β1/γ2	2.96	2024-07-24	10.1016/j.celrep.2024.114505
	8ZSV (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	RO5263397	-		2.96	2024-07-24	10.1016/j.celrep.2024.114505
	8ZSS	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5263397	-	chim(NtGi1-Gs)/β1/γ2	3.07	2024-07-24	10.1016/j.celrep.2024.114505
	8ZSS (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5263397	-		3.07	2024-07-24	10.1016/j.celrep.2024.114505
	8ZSP	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	LSD	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.14	2024-07-24	10.1016/j.celrep.2024.114505
	8ZSP (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	LSD	-		3.14	2024-07-24	10.1016/j.celrep.2024.114505
	8ZSJ	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	-	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-07-24	10.1016/j.celrep.2024.114505
	8ZSJ (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	-	-		2.8	2024-07-24	10.1016/j.celrep.2024.114505
	8UHB	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5256390	-	Gs/β1/γ2	3.35	2024-01-10	10.1038/s41467-023-44601-4
	8UHB (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5256390	-		3.35	2024-01-10	10.1038/s41467-023-44601-4
	8WCC	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Cyclohexylammonium Ion	-	-	3.04	2023-12-27	10.1016/j.cell.2023.10.014
	8WCB	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Cyclohexylammonium Ion	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2023-12-27	10.1016/j.cell.2023.10.014
	8WCB (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Cyclohexylammonium Ion	-		3.1	2023-12-27	10.1016/j.cell.2023.10.014
	8WC9	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8651	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.2	2023-12-27	10.1016/j.cell.2023.10.014
	8WC9 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8651	-		3.2	2023-12-27	10.1016/j.cell.2023.10.014
	8WCA	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	2-Phenylethylamine	-	chim(NtGi1-Gs)/β1/γ2	3.48	2023-12-27	10.1016/j.cell.2023.10.014
	8WCA (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	2-Phenylethylamine	-		3.48	2023-12-27	10.1016/j.cell.2023.10.014
	8WC8	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	ZH8651	-	chim(NtGi1-Gs)/β1/γ2	2.9	2023-12-27	10.1016/j.cell.2023.10.014
	8WC8 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	ZH8651	-		2.9	2023-12-27	10.1016/j.cell.2023.10.014
	8WC7	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8667	-	chim(NtGi1-Gs)/β1/γ2	3.1	2023-12-27	10.1016/j.cell.2023.10.014
	8WC7 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8667	-		3.1	2023-12-27	10.1016/j.cell.2023.10.014
	8WC6	A	Amine	Trace Amine Receptors	TA1	Mus musculus	2-Phenylethylamine	-	chim(NtGi1-Gs)/β1/γ2	3.2	2023-12-27	10.1016/j.cell.2023.10.014
	8WC6 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	2-Phenylethylamine	-		3.2	2023-12-27	10.1016/j.cell.2023.10.014
	8WC5	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Tetramethylammonium Ion	-	chim(NtGi1-Gs)/β1/γ2	3.3	2023-12-27	10.1016/j.cell.2023.10.014
	8WC5 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Tetramethylammonium Ion	-		3.3	2023-12-27	10.1016/j.cell.2023.10.014
	8WC4	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8651	-	chim(NtGi1-Gs)/β1/γ2	3.1	2023-12-27	10.1016/j.cell.2023.10.014
	8WC4 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8651	-		3.1	2023-12-27	10.1016/j.cell.2023.10.014
	8WC3	A	Amine	Trace Amine Receptors	TA1	Mus musculus	SEP-363856	-	chim(NtGi1-Gs)/β1/γ2	3	2023-12-27	10.1016/j.cell.2023.10.014
	8WC3 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	SEP-363856	-		3	2023-12-27	10.1016/j.cell.2023.10.014
	8W8A	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5256390	-	chim(NtGi1L-Gs)/β1/γ2	2.8	2023-11-22	10.1038/s41586-023-06775-1
	8W8A (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5256390	-		2.8	2023-11-22	10.1038/s41586-023-06775-1
	8W89	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	PEA	-	chim(NtGi1L-Gs)/β1/γ2	3	2023-11-22	10.1038/s41586-023-06775-1
	8W89 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	PEA	-		3	2023-11-22	10.1038/s41586-023-06775-1
	8W87	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	METH	-	chim(NtGi1L-Gs)/β1/γ2	2.8	2023-11-22	10.1038/s41586-023-06775-1
	8W87 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	METH	-		2.8	2023-11-22	10.1038/s41586-023-06775-1
	8W88	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	SEP-363856	-	Gs/β1/γ2	2.6	2023-11-22	10.1038/s41586-023-06775-1
	8W88 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	SEP-363856	-		2.6	2023-11-22	10.1038/s41586-023-06775-1
	8JSO	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	AMPH	-	chim(NtGi1-Gs)/β1/γ2	3.4	2023-11-15	10.1038/s41586-023-06804-z
	8JSO (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	AMPH	-		3.4	2023-11-15	10.1038/s41586-023-06804-z
	8JLR	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	A77636	-	chim(NtGi1-Gs)/β1/γ2	3	2023-11-15	10.1038/s41586-023-06804-z
	8JLR (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	A77636	-		3	2023-11-15	10.1038/s41586-023-06804-z
	8JLK	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Ulotaront	-	chim(NtGi1-Gs)/β1/γ2	3.22	2023-11-15	10.1038/s41586-023-06804-z
	8JLK (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Ulotaront	-		3.22	2023-11-15	10.1038/s41586-023-06804-z
	8JLJ	A	Amine	Trace Amine Receptors	TA1	Mus musculus	T1AM	-	chim(NtGi1-Gs)/β1/γ2	3.1	2023-11-15	10.1038/s41586-023-06804-z
	8JLJ (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	T1AM	-		3.1	2023-11-15	10.1038/s41586-023-06804-z
	8JLQ	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Fenoldopam	-	Gs/β1/γ2	2.84	2023-11-15	10.1038/s41586-023-06804-z
	8JLQ (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Fenoldopam	-		2.84	2023-11-15	10.1038/s41586-023-06804-z
	8JLP	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Ralmitaront	-	Gs/β1/γ2	3.23	2023-11-15	10.1038/s41586-023-06804-z
	8JLP (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Ralmitaront	-		3.23	2023-11-15	10.1038/s41586-023-06804-z
	8JLO	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Ulotaront	-	Gs/β1/γ2	3.52	2023-11-15	10.1038/s41586-023-06804-z
	8JLO (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Ulotaront	-		3.52	2023-11-15	10.1038/s41586-023-06804-z
	8JLN	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	T1AM	-	Gs/β1/γ2	3.24	2023-11-15	10.1038/s41586-023-06804-z
	8JLN (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	T1AM	-		3.24	2023-11-15	10.1038/s41586-023-06804-z

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