psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:A85	R:R:Y27	5.34	No	Yes	0	5	6
2	R:R:E86	R:R:Y27	12.35	No	Yes	0	4	6
3	R:R:M30	R:R:M81	7.22	Yes	No	4	6	6
4	R:R:M30	R:R:W291	19.78	Yes	Yes	0	6	4
5	R:R:M81	R:R:V31	4.56	No	No	0	6	5
6	R:R:I33	R:R:W291	4.7	No	Yes	0	7	4
7	R:R:I33	R:R:L295	5.71	No	No	0	7	5
8	R:R:I34	R:R:M77	4.37	No	Yes	0	6	7
9	R:R:M77	R:R:T37	6.02	Yes	No	0	7	7
10	R:R:T298	R:R:T37	4.71	No	No	0	7	7
11	R:R:F70	R:R:L38	8.53	No	No	0	7	6
12	R:R:G40	R:R:P301	4.06	No	No	0	9	9
13	R:R:A66	R:R:N41	4.69	No	No	0	9	9
14	R:R:D69	R:R:N41	10.77	Yes	No	0	9	9
15	R:R:N41	R:R:P301	11.4	No	No	0	9	9
16	R:R:L42	R:R:V46	4.47	No	No	0	4	4
17	R:R:F70	R:R:L42	6.09	No	No	0	7	4
18	R:R:F306	R:R:I43	5.02	Yes	No	0	6	7
19	R:R:F311	R:R:V44	6.55	Yes	No	0	9	9
20	R:R:H63	R:R:I45	6.63	Yes	No	5	6	8
21	R:R:I45	R:R:T67	4.56	No	No	5	8	6
22	R:R:F311	R:R:S47	6.61	Yes	No	0	9	8
23	R:R:M318	R:R:S47	4.6	No	No	0	6	8
24	R:R:I48	R:R:L54	4.28	No	No	0	7	8
25	R:R:I48	R:R:N59	5.66	No	No	0	7	9
26	R:R:H63	R:R:I48	9.28	Yes	No	0	6	7
27	R:R:F51	R:R:H50	9.05	No	No	0	5	5
28	R:R:F51	R:R:Q53	8.2	No	No	0	5	5
29	R:R:H55	R:R:K52	15.72	No	No	0	8	6
30	R:R:L54	R:R:Q53	5.32	No	No	0	8	5
31	R:R:A314	R:R:L54	4.73	No	No	0	7	8
32	R:R:H55	R:R:W60	12.7	No	No	0	8	4
33	R:R:N59	R:R:T56	11.7	No	No	0	9	8
34	R:R:I140	R:R:P57	5.08	No	No	0	7	6
35	R:R:D120	R:R:T58	14.45	No	No	2	9	8
36	R:R:T58	R:R:Y131	6.24	No	Yes	2	8	7
37	R:R:N59	R:R:W310	5.65	No	No	0	9	6
38	R:R:H63	R:R:W60	9.52	Yes	No	0	6	4
39	R:R:I117	R:R:L61	4.28	Yes	No	0	9	7
40	R:R:I140	R:R:L61	7.14	No	No	0	7	7
41	R:R:H63	R:R:T67	4.11	Yes	No	5	6	6
42	R:R:H113	R:R:S64	11.16	Yes	No	1	8	9
43	R:R:I144	R:R:S64	10.84	No	No	0	7	9
44	R:R:S64	R:R:W148	6.18	No	No	1	9	9
45	R:R:D69	R:R:M65	4.16	Yes	Yes	1	9	9
46	R:R:H113	R:R:M65	5.25	Yes	Yes	1	8	9
47	R:R:I117	R:R:M65	4.37	Yes	Yes	1	9	9
48	R:R:M65	R:R:N300	5.61	Yes	Yes	1	9	9
49	R:R:M65	R:R:Y304	7.18	Yes	Yes	1	9	9
50	R:R:H113	R:R:V68	5.54	Yes	No	1	8	8
51	R:R:V68	R:R:W148	6.13	No	No	1	8	9
52	R:R:D69	R:R:S110	5.89	Yes	No	0	9	9
53	R:R:D69	R:R:S297	11.78	Yes	No	0	9	9
54	R:R:D69	R:R:N300	8.08	Yes	Yes	1	9	9
55	R:R:L72	R:R:M77	4.24	No	Yes	0	7	7
56	R:R:L106	R:R:L72	6.92	No	No	0	6	7
57	R:R:L72	R:R:S107	4.5	No	Yes	0	7	6
58	R:R:G73	R:R:M77	6.99	No	Yes	0	7	7
59	R:R:H99	R:R:V76	4.15	Yes	No	0	5	7
60	R:R:D103	R:R:V76	11.69	Yes	No	0	6	7
61	R:R:M77	R:R:Y294	15.57	Yes	Yes	0	7	7
62	R:R:H99	R:R:Y79	7.62	Yes	No	0	5	5
63	R:R:R83	R:R:S80	7.91	No	No	1	4	6
64	R:R:H99	R:R:S80	6.97	Yes	No	1	5	6
65	R:R:S80	R:R:Y294	7.63	No	Yes	0	6	7
66	R:R:F91	R:R:V82	3.93	No	No	0	6	5
67	R:R:H99	R:R:R83	4.51	Yes	No	1	5	4
68	L:L:?1	R:R:R83	6.65	Yes	No	1	0	4
69	R:R:D287	R:R:S84	10.31	No	No	0	3	5
70	R:R:E86	R:R:Y90	10.1	No	No	0	4	1
71	R:R:C88	R:R:Y90	9.41	No	No	0	4	1
72	R:R:F91	R:R:W89	19.04	No	Yes	0	6	7
73	R:R:C96	R:R:W89	7.84	No	Yes	0	9	7
74	R:R:H99	R:R:W89	4.23	Yes	Yes	0	5	7
75	R:R:E93	R:R:K97	10.8	No	No	0	2	6
76	R:R:C182	R:R:C96	7.28	No	No	0	9	9
77	R:R:F160	R:R:I98	5.02	No	No	0	4	4
78	R:R:F156	R:R:S101	11.89	Yes	No	6	4	6
79	R:R:I159	R:R:S101	7.74	No	No	0	6	6
80	R:R:F160	R:R:S101	5.28	No	No	6	4	6
81	R:R:F156	R:R:T102	5.19	Yes	No	0	4	4
82	R:R:D103	R:R:S107	4.42	Yes	Yes	1	6	6
83	R:R:D103	R:R:Y294	10.34	Yes	Yes	0	6	7
84	L:L:?1	R:R:D103	14.85	Yes	Yes	1	0	6
85	R:R:I104	R:R:M158	4.37	No	No	0	4	5
86	L:L:?1	R:R:I104	16.74	Yes	No	0	0	4
87	R:R:A152	R:R:M105	4.83	No	No	0	3	5
88	R:R:F156	R:R:M105	7.46	Yes	No	0	4	5
89	R:R:S107	R:R:W264	4.94	Yes	Yes	1	6	8
90	L:L:?1	R:R:S107	10.56	Yes	Yes	1	0	6
91	R:R:S108	R:R:S198	6.52	No	No	1	5	6
92	L:L:?1	R:R:S108	4.7	Yes	No	1	0	5
93	R:R:I111	R:R:W264	10.57	No	Yes	0	8	8
94	R:R:F112	R:R:S147	3.96	No	No	0	6	7
95	R:R:F112	R:R:P151	7.22	No	No	0	6	8
96	R:R:F112	R:R:P202	7.22	No	No	0	6	9
97	R:R:H113	R:R:S147	12.55	Yes	No	0	8	7
98	R:R:H113	R:R:W148	7.41	Yes	No	1	8	9
99	R:R:F260	R:R:L114	4.87	Yes	Yes	1	9	9
100	R:R:L114	R:R:N296	4.12	Yes	Yes	1	9	9
101	R:R:L114	R:R:N300	12.36	Yes	Yes	1	9	9
102	R:R:L114	R:R:Y304	8.21	Yes	Yes	1	9	9
103	R:R:P202	R:R:S115	5.34	No	No	0	9	7
104	R:R:F116	R:R:M143	18.66	No	No	0	7	6
105	R:R:F116	R:R:S147	5.28	No	No	0	7	7
106	R:R:I117	R:R:R121	5.01	Yes	No	0	9	9
107	R:R:I117	R:R:Y304	7.25	Yes	Yes	1	9	9
108	R:R:M206	R:R:S118	6.13	Yes	No	1	9	8
109	R:R:S118	R:R:Y210	5.09	No	Yes	1	8	9
110	R:R:D120	R:R:Y131	10.34	No	Yes	2	9	7
111	R:R:D120	R:R:M135	8.32	No	Yes	2	9	7
112	R:R:R121	R:R:Y308	11.32	No	Yes	0	9	8
113	R:R:C126	R:R:Y122	12.1	No	No	0	6	8
114	R:R:V209	R:R:Y122	8.83	No	No	0	7	8
115	R:R:R212	R:R:Y122	15.43	No	No	0	5	8
116	R:R:M135	R:R:Y123	8.38	Yes	No	0	7	4
117	R:R:A124	R:R:Y131	9.34	No	Yes	0	8	7
118	R:R:I213	R:R:V125	6.14	No	No	0	9	8
119	R:R:D127	R:R:R130	16.68	No	No	0	5	5
120	R:R:D127	R:R:K134	5.53	No	No	0	5	4
121	R:R:M135	R:R:Y131	4.79	Yes	Yes	2	7	7
122	R:R:M135	R:R:M143	4.33	Yes	No	2	7	6
123	R:R:L138	R:R:N136	4.12	No	No	0	4	8
124	R:R:N136	R:R:V139	5.91	No	No	0	8	5
125	R:R:F145	R:R:S149	11.89	No	No	0	5	4
126	R:R:I146	R:R:V150	4.61	No	No	0	3	4
127	R:R:F154	R:R:M158	7.46	No	No	0	4	5
128	R:R:F156	R:R:F160	4.29	Yes	No	6	4	4
129	R:R:I159	R:R:M158	8.75	No	No	0	6	5
130	R:R:E162	R:R:F165	4.66	No	Yes	0	5	4
131	R:R:K166	R:R:L163	8.46	No	No	0	3	6
132	R:R:F165	R:R:N164	15.71	Yes	No	0	4	4
133	R:R:F165	R:R:Y172	23.73	Yes	No	3	4	3
134	R:R:F165	R:R:F185	10.72	Yes	Yes	3	4	1
135	R:R:E169	R:R:E170	17.76	No	No	0	4	3
136	R:R:H175	R:R:I171	3.98	Yes	No	3	3	2
137	R:R:I171	R:R:Y279	4.84	No	Yes	3	2	1
138	R:R:V176	R:R:Y172	13.88	No	No	0	3	3
139	R:R:F185	R:R:Y172	12.38	Yes	No	3	1	3
140	R:R:H177	R:R:Y173	26.13	No	No	0	4	2
141	R:R:H175	R:R:R179	12.41	Yes	No	0	3	2
142	R:R:F185	R:R:H175	12.44	Yes	Yes	3	1	3
143	R:R:H175	R:R:Y279	26.13	Yes	Yes	3	3	1
144	R:R:H177	R:R:V176	4.15	No	No	0	4	3
145	R:R:R179	R:R:S183	7.91	No	No	0	2	4
146	R:R:F186	R:R:V184	11.8	Yes	No	1	1	4
147	L:L:?1	R:R:V184	8.15	Yes	No	1	0	4
148	R:R:F185	R:R:Y279	11.35	Yes	Yes	3	1	1
149	R:R:F186	R:R:S190	6.61	Yes	No	0	1	6
150	R:R:F186	R:R:G191	4.52	Yes	No	0	1	4
151	L:L:?1	R:R:F186	5.71	Yes	Yes	1	0	1
152	R:R:K188	R:R:P275	5.02	Yes	No	0	3	4
153	R:R:I189	R:R:L193	4.28	No	No	0	4	3
154	L:L:?1	R:R:T194	6.91	Yes	No	0	0	5
155	R:R:F195	R:R:F199	6.43	Yes	Yes	1	5	8
156	R:R:F195	R:R:F268	4.29	Yes	Yes	1	5	7
157	R:R:F195	R:R:V272	15.73	Yes	No	0	5	6
158	R:R:F268	R:R:S198	3.96	Yes	No	1	7	6
159	L:L:?1	R:R:S198	9.39	Yes	No	1	0	6
160	R:R:F199	R:R:F260	4.29	Yes	Yes	1	8	9
161	R:R:C265	R:R:F199	4.19	No	Yes	0	6	8
162	R:R:F199	R:R:F268	22.51	Yes	Yes	1	8	7
163	R:R:M206	R:R:Y210	4.79	Yes	Yes	1	9	9
164	R:R:M206	R:R:M257	5.78	Yes	No	0	9	8
165	R:R:F260	R:R:M206	8.71	Yes	Yes	1	9	9
166	R:R:L207	R:R:M257	7.07	No	No	0	5	8
167	R:R:V256	R:R:Y210	6.31	No	Yes	0	8	9
168	R:R:L215	R:R:Y211	14.07	No	No	0	4	3
169	R:R:V250	R:R:Y214	6.31	No	No	0	8	5
170	R:R:E219	R:R:Q220	5.1	No	No	0	3	6
171	R:R:E219	R:R:R222	5.82	No	No	0	3	4
172	R:R:L223	R:R:R222	7.29	No	No	0	4	4
173	R:R:D226	R:R:R222	5.96	No	No	0	4	4
174	R:R:R247	R:R:V250	10.46	No	No	0	5	8
175	R:R:F307	R:R:T252	6.49	No	No	0	7	9
176	R:R:L261	R:R:M257	4.24	No	No	0	6	8
177	R:R:F299	R:R:V259	3.93	No	No	0	6	6
178	R:R:V259	R:R:V303	4.81	No	No	0	6	8
179	R:R:F260	R:R:N296	4.83	Yes	Yes	1	9	9
180	R:R:C263	R:R:N296	4.72	No	Yes	0	8	9
181	R:R:F267	R:R:W264	6.01	Yes	Yes	1	5	8
182	R:R:F268	R:R:W264	12.03	Yes	Yes	1	7	8
183	R:R:G293	R:R:W264	8.44	No	Yes	0	7	8
184	R:R:N296	R:R:W264	10.17	Yes	Yes	1	9	8
185	L:L:?1	R:R:W264	8.9	Yes	Yes	1	0	8
186	R:R:C265	R:R:P266	5.65	No	No	0	6	9
187	R:R:F267	R:R:F268	9.65	Yes	Yes	1	5	7
188	R:R:F267	R:R:T271	9.08	Yes	No	0	5	5
189	R:R:F267	R:R:L289	4.87	Yes	No	0	5	5
190	L:L:?1	R:R:F267	13.33	Yes	Yes	1	0	5
191	L:L:?1	R:R:F268	12.38	Yes	Yes	1	0	7
192	R:R:I269	R:R:M273	4.37	No	No	0	6	4
193	R:R:D274	R:R:Y279	5.75	No	Yes	0	2	1
194	R:R:D274	R:R:I281	5.6	No	No	0	2	2
195	R:R:I280	R:R:L277	4.28	No	No	0	1	3
196	R:R:I281	R:R:L285	5.71	No	No	0	2	4
197	R:R:L285	R:R:P282	6.57	No	No	0	4	1
198	R:R:F292	R:R:V288	3.93	No	No	0	7	4
199	L:L:?1	R:R:I290	11.16	Yes	No	0	0	5
200	R:R:W291	R:R:Y294	13.5	Yes	Yes	0	4	7
201	R:R:F299	R:R:L295	6.09	No	No	0	6	5
202	R:R:N296	R:R:N300	10.9	Yes	Yes	1	9	9
203	R:R:F299	R:R:T298	11.67	No	No	0	6	7
204	R:R:F306	R:R:M302	4.98	Yes	No	0	6	6
205	R:R:V303	R:R:Y304	7.57	No	Yes	0	8	9
206	R:R:A305	R:R:F311	9.71	No	Yes	0	7	9
207	R:R:F306	R:R:F311	5.36	Yes	Yes	0	6	9
208	R:R:F307	R:R:Y308	8.25	No	Yes	0	7	8
209	R:R:W310	R:R:Y308	14.47	No	Yes	0	6	8
210	R:R:P309	R:R:R312	4.32	No	No	0	5	8
211	R:R:F311	R:R:W310	4.01	Yes	No	0	9	6
212	R:R:A109	R:R:P151	3.74	No	No	0	7	8
213	R:R:F51	R:R:M317	3.73	No	No	0	5	5
214	R:R:S84	R:R:W291	3.71	No	Yes	0	5	4
215	R:R:G167	R:R:S187	3.71	No	No	0	4	4
216	R:R:F306	R:R:L315	3.65	Yes	No	0	6	7
217	R:R:K218	R:R:Y214	3.58	No	No	0	6	5
218	R:R:P151	R:R:V150	3.53	No	No	0	8	4
219	R:R:I137	R:R:W60	3.52	No	No	0	2	4
220	L:L:?1	R:R:S183	3.52	Yes	No	0	0	4
221	R:R:L253	R:R:Y210	3.52	No	Yes	0	7	9
222	L:L:?1	R:R:T100	3.46	Yes	No	0	0	4
223	R:R:A168	R:R:S187	3.42	No	No	0	3	4
224	R:R:I201	R:R:P202	3.39	No	No	0	6	9
225	R:R:C141	R:R:I137	3.27	No	No	0	1	2
226	R:R:C270	R:R:I281	3.27	No	No	0	4	2
227	R:R:A155	R:R:I104	3.25	No	No	0	6	4
228	R:R:A168	R:R:I171	3.25	No	No	0	3	2
229	R:R:S118	R:R:V209	3.23	No	No	0	8	7
230	L:L:?1	R:R:N286	3.22	Yes	No	0	0	4
231	R:R:V192	R:R:V272	3.21	No	No	0	5	6
232	R:R:C74	R:R:L71	3.17	No	No	0	4	7
233	R:R:C74	R:R:L75	3.17	No	No	0	4	5
234	R:R:F195	R:R:Y200	3.09	Yes	No	0	5	5
235	R:R:I43	R:R:V39	3.07	No	No	0	7	5
236	R:R:K188	R:R:S187	3.06	Yes	No	0	3	4
237	R:R:H87	R:R:P283	3.05	No	No	0	4	1
238	R:R:M135	R:R:V139	3.04	Yes	No	2	7	5
239	R:R:M143	R:R:V139	3.04	No	No	2	6	5
240	R:R:M196	R:R:V192	3.04	No	No	0	5	5
241	R:R:F260	R:R:G203	3.01	Yes	No	0	9	6
242	R:R:L35	R:R:V31	2.98	No	No	0	5	5
243	R:R:C178	R:R:H175	2.95	No	Yes	0	4	3
244	R:R:I119	R:R:I205	2.94	No	No	0	6	6
245	R:R:I159	R:R:K97	2.91	No	No	0	6	6
246	R:R:I189	R:R:K188	2.91	No	Yes	0	4	3
247	R:R:K313	R:R:M317	2.88	No	No	0	5	5
248	R:R:I213	R:R:L253	2.85	No	No	0	9	7
249	R:R:K218	R:R:L215	2.82	No	No	0	6	4
250	R:R:G92	R:R:W89	2.81	No	Yes	0	8	7
251	R:R:C74	R:R:F70	2.79	No	No	0	4	7
252	R:R:A85	R:R:R23	2.77	No	No	0	5	4
253	R:R:L106	R:R:L71	2.77	No	No	0	6	7
254	R:R:L106	R:R:L75	2.77	No	No	0	6	5
255	R:R:L161	R:R:L163	2.77	No	No	0	4	6
256	R:R:I216	R:R:Q220	2.74	No	No	0	5	6
257	R:R:D287	R:R:H87	2.52	No	No	0	3	4
258	R:R:F276	R:R:K188	2.48	No	Yes	0	5	3
259	R:R:F307	R:R:K251	2.48	No	No	0	7	6
260	R:R:L129	R:R:R130	2.43	No	No	0	7	5
261	R:R:I119	R:R:Y123	2.42	No	No	0	6	4
262	R:R:M30	R:R:Y27	2.39	Yes	Yes	4	6	6
263	R:R:M81	R:R:Y27	2.39	No	Yes	4	6	6
264	R:R:K134	R:R:Y123	2.39	No	No	0	4	4
265	R:R:G180	R:R:G181	2.11	No	No	0	4	3
266	R:R:C182	R:R:G181	1.96	No	No	0	9	3
267	R:R:A217	R:R:A249	1.79	No	No	0	8	8
268	R:R:P282	R:R:T284	1.75	No	No	0	1	3
269	R:R:G167	R:R:K166	1.74	No	No	0	4	3
270	R:R:G157	R:R:L161	1.71	No	No	0	6	4
271	R:R:G258	R:R:L261	1.71	No	No	0	5	6
272	R:R:M77	R:R:P78	1.68	Yes	No	0	7	8
273	R:R:C126	R:R:I216	1.64	No	No	0	6	5
274	R:R:C270	R:R:I269	1.64	No	No	0	4	6
275	R:R:S25	R:R:V22	1.62	No	No	0	4	3
276	R:R:A305	R:R:I62	1.62	No	No	0	7	8
277	R:R:S149	R:R:V150	1.62	No	No	0	4	4
278	R:R:D127	R:R:P128	1.61	No	No	0	5	8
279	R:R:I205	R:R:S204	1.55	No	No	0	6	4
280	R:R:I98	R:R:V94	1.54	No	No	0	4	1
281	R:R:I255	R:R:V256	1.54	No	No	0	6	8
282	R:R:I255	R:R:V259	1.54	No	No	0	6	6
283	R:R:M302	R:R:T36	1.51	No	No	0	6	5
284	R:R:A168	R:R:E170	1.51	No	No	0	3	3
285	R:R:L26	R:R:S25	1.5	No	No	0	5	4
286	R:R:L138	R:R:V142	1.49	No	No	0	4	3
287	R:R:K248	R:R:K251	1.44	No	No	0	8	6
288	R:R:L26	R:R:M30	1.41	No	Yes	0	5	6
289	R:R:L277	R:R:M273	1.41	No	No	0	3	4
290	R:R:H63	R:R:S49	1.39	Yes	No	0	6	3
291	R:R:P309	R:R:Y308	1.39	No	Yes	0	5	8
292	R:R:L29	R:R:L32	1.38	No	No	0	5	5
293	R:R:A133	R:R:R130	1.38	No	No	0	5	5
294	R:R:E170	R:R:K174	1.35	No	No	0	3	4
295	R:R:N228	R:R:Q229	1.32	No	No	0	4	3
296	R:R:F95	R:R:V94	1.31	No	No	0	5	1
297	R:R:F154	R:R:T197	1.3	No	No	0	4	4
298	R:R:L253	R:R:Y214	1.17	No	No	0	7	5
299	R:R:H278	R:R:Y279	1.09	No	Yes	0	1	1

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y27	5.6175	4	4	6
2	R:R:M30	7.7	4	4	6
3	R:R:H63	6.186	5	5	6
4	R:R:M65	5.314	5	1	9
5	R:R:D69	8.136	5	1	9
6	R:R:M77	6.47833	6	0	7
7	R:R:W89	8.48	4	0	7
8	R:R:H99	5.496	5	1	5
9	R:R:D103	10.325	4	1	6
10	R:R:S107	6.105	4	1	6
11	R:R:H113	8.382	5	1	8
12	R:R:L114	7.39	4	1	9
13	R:R:I117	5.2275	4	1	9
14	R:R:Y131	7.6775	4	2	7
15	R:R:M135	5.772	5	2	7
16	R:R:F156	7.2075	4	6	4
17	R:R:F165	13.705	4	3	4
18	R:R:H175	11.582	5	3	3
19	R:R:F185	11.7225	4	3	1
20	R:R:F186	7.16	4	1	1
21	R:R:K188	3.3675	4	0	3
22	R:R:F195	7.385	4	1	5
23	R:R:F199	9.355	4	1	8
24	R:R:M206	6.3525	4	1	9
25	R:R:Y210	4.9275	4	1	9
26	R:R:F260	5.142	5	1	9
27	R:R:W264	8.72286	7	1	8
28	R:R:F267	8.588	5	1	5
29	R:R:F268	10.8033	6	1	7
30	R:R:Y279	9.832	5	3	1
31	R:R:W291	10.4225	4	0	4
32	R:R:Y294	11.76	4	0	7
33	R:R:N296	6.948	5	1	9
34	R:R:N300	9.2375	4	1	9
35	R:R:Y304	7.5525	4	1	9
36	R:R:F306	4.7525	4	0	6
37	R:R:Y308	8.8575	4	0	8
38	R:R:F311	6.448	5	0	9
39	L:L:?1	8.72688	16	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:M30	R:R:Y27	10.7349	2.39	Yes	Yes	4	6	6
2	R:R:M30	R:R:W291	23.1674	19.78	Yes	Yes	0	6	4
3	R:R:I33	R:R:W291	10.9454	4.7	No	Yes	0	7	4
4	R:R:I33	R:R:L295	10.8493	5.71	No	No	0	7	5
5	R:R:W291	R:R:Y294	24.1786	13.5	Yes	Yes	0	4	7
6	R:R:F299	R:R:L295	10.9088	6.09	No	No	0	6	5
7	R:R:L106	R:R:L72	19.8042	6.92	No	No	0	6	7
8	R:R:C74	R:R:F70	12.2769	2.79	No	No	0	4	7
9	R:R:D103	R:R:Y294	25.6841	10.34	Yes	Yes	0	6	7
10	R:R:S107	R:R:W264	24.444	4.94	Yes	Yes	1	6	8
11	R:R:N296	R:R:W264	100	10.17	Yes	Yes	1	9	8
12	R:R:N296	R:R:N300	64.2766	10.9	Yes	Yes	1	9	9
13	L:L:?1	R:R:D103	21.2135	14.85	Yes	Yes	1	0	6
14	L:L:?1	R:R:W264	71.5887	8.9	Yes	Yes	1	0	8
15	R:R:F299	R:R:V259	13.5536	3.93	No	No	0	6	6
16	R:R:V259	R:R:V303	12.3684	4.81	No	No	0	6	8
17	R:R:V303	R:R:Y304	13.1097	7.57	No	Yes	0	8	9
18	R:R:I117	R:R:Y304	37.3112	7.25	Yes	Yes	1	9	9
19	R:R:I117	R:R:R121	64.1027	5.01	Yes	No	0	9	9
20	R:R:R121	R:R:Y308	62.6476	11.32	No	Yes	0	9	8
21	R:R:W310	R:R:Y308	52.6128	14.47	No	Yes	0	6	8
22	R:R:F311	R:R:W310	20.8154	4.01	Yes	No	0	9	6
23	R:R:F306	R:R:F311	10.5656	5.36	Yes	Yes	0	6	9
24	R:R:N59	R:R:W310	32.3556	5.65	No	No	0	9	6
25	R:R:I48	R:R:N59	29.1663	5.66	No	No	0	7	9
26	R:R:H63	R:R:I48	15.7683	9.28	Yes	No	0	6	7
27	R:R:I48	R:R:L54	12.3273	4.28	No	No	0	7	8
28	R:R:M65	R:R:Y304	11.9337	7.18	Yes	Yes	1	9	9
29	R:R:H113	R:R:M65	60.2041	5.25	Yes	Yes	1	8	9
30	R:R:H113	R:R:S147	53.02	12.55	Yes	No	0	8	7
31	R:R:F116	R:R:S147	36.4098	5.28	No	No	0	7	7
32	R:R:F116	R:R:M143	34.8449	18.66	No	No	0	7	6
33	R:R:M135	R:R:M143	26.5855	4.33	Yes	No	2	7	6
34	R:R:M65	R:R:N300	64.1805	5.61	Yes	Yes	1	9	9
35	R:R:H99	R:R:W89	13.3019	4.23	Yes	Yes	0	5	7
36	L:L:?1	R:R:I104	25.6383	16.74	Yes	No	0	0	4
37	R:R:I104	R:R:M158	22.7235	4.37	No	No	0	4	5
38	R:R:I159	R:R:M158	18.4406	8.75	No	No	0	6	5
39	R:R:I159	R:R:S101	14.0386	7.74	No	No	0	6	6
40	R:R:F112	R:R:S147	17.1548	3.96	No	No	0	6	7
41	R:R:F112	R:R:P151	10.4008	7.22	No	No	0	6	8
42	R:R:F260	R:R:N296	25.9175	4.83	Yes	Yes	1	9	9
43	L:L:?1	R:R:F268	17.9006	12.38	Yes	Yes	1	0	7
44	R:R:F199	R:R:F268	16.0245	22.51	Yes	Yes	1	8	7
45	R:R:F199	R:R:F260	21.7031	4.29	Yes	Yes	1	8	9
46	R:R:L114	R:R:N296	25.556	4.12	Yes	Yes	1	9	9
47	R:R:F260	R:R:M206	51.812	8.71	Yes	Yes	1	9	9
48	R:R:M206	R:R:S118	22.4398	6.13	Yes	No	1	9	8
49	R:R:S118	R:R:V209	22.1104	3.23	No	No	0	8	7
50	R:R:V209	R:R:Y122	19.9231	8.83	No	No	0	7	8
51	R:R:C126	R:R:Y122	15.5212	12.1	No	No	0	6	8
52	R:R:M135	R:R:Y123	17.1548	8.38	Yes	No	0	7	4
53	R:R:L253	R:R:Y210	17.8777	3.52	No	Yes	0	7	9
54	R:R:K134	R:R:Y123	10.4008	2.39	No	No	0	4	4
55	L:L:?1	R:R:S183	56.6212	3.52	Yes	No	0	0	4
56	R:R:R179	R:R:S183	55.4956	7.91	No	No	0	2	4
57	R:R:H175	R:R:R179	54.2464	12.41	Yes	No	0	3	2
58	R:R:F185	R:R:H175	12.0756	12.44	Yes	Yes	3	1	3
59	R:R:H175	R:R:I171	23.5701	3.98	Yes	No	3	3	2
60	R:R:A168	R:R:I171	23.538	3.25	No	No	0	3	2
61	R:R:A168	R:R:S187	17.4613	3.42	No	No	0	3	4
62	R:R:H175	R:R:Y279	17.2371	26.13	Yes	Yes	3	3	1
63	R:R:L253	R:R:Y214	12.0756	1.17	No	No	0	7	5
64	R:R:C126	R:R:I216	13.3065	1.64	No	No	0	6	5
65	R:R:I216	R:R:Q220	11.2519	2.74	No	No	0	5	6
66	R:R:D274	R:R:Y279	15.5532	5.75	No	Yes	0	2	1
67	R:R:D274	R:R:I281	14.0386	5.6	No	No	0	2	2
68	R:R:L114	R:R:Y304	39.8371	8.21	Yes	Yes	1	9	9
69	R:R:F260	R:R:L114	22.4673	4.87	Yes	Yes	1	9	9
70	R:R:M206	R:R:Y210	19.8499	4.79	Yes	Yes	1	9	9
71	R:R:L72	R:R:S107	24.6042	4.5	No	Yes	0	7	6
72	R:R:I117	R:R:M65	32.4243	4.37	Yes	Yes	1	9	9
73	L:L:?1	R:R:R83	16.02	6.65	Yes	No	1	0	4
74	R:R:H99	R:R:R83	13.4895	4.51	Yes	No	1	5	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:L72	R:R:S107	4.5	0	No	Yes	7	6	2	1
R:R:H99	R:R:V76	4.15	1	Yes	No	5	7	2	2
R:R:D103	R:R:V76	11.69	1	Yes	No	6	7	1	2
R:R:R83	R:R:S80	7.91	1	No	No	4	6	1	2
R:R:H99	R:R:S80	6.97	1	Yes	No	5	6	2	2
R:R:S80	R:R:Y294	7.63	1	No	Yes	6	7	2	2
R:R:H99	R:R:R83	4.51	1	Yes	No	5	4	2	1
L:L:?1	R:R:R83	6.65	1	Yes	No	0	4	0	1
R:R:D103	R:R:S107	4.42	1	Yes	Yes	6	6	1	1
R:R:D103	R:R:Y294	10.34	1	Yes	Yes	6	7	1	2
L:L:?1	R:R:D103	14.85	1	Yes	Yes	0	6	0	1
R:R:I104	R:R:M158	4.37	0	No	No	4	5	1	2
L:L:?1	R:R:I104	16.74	1	Yes	No	0	4	0	1
R:R:S107	R:R:W264	4.94	1	Yes	Yes	6	8	1	1
L:L:?1	R:R:S107	10.56	1	Yes	Yes	0	6	0	1
R:R:S108	R:R:S198	6.52	1	No	No	5	6	1	1
L:L:?1	R:R:S108	4.7	1	Yes	No	0	5	0	1
R:R:I111	R:R:W264	10.57	0	No	Yes	8	8	2	1
R:R:R179	R:R:S183	7.91	0	No	No	2	4	2	1
R:R:F186	R:R:V184	11.8	1	Yes	No	1	4	1	1
L:L:?1	R:R:V184	8.15	1	Yes	No	0	4	0	1
R:R:F186	R:R:S190	6.61	1	Yes	No	1	6	1	2
R:R:F186	R:R:G191	4.52	1	Yes	No	1	4	1	2
L:L:?1	R:R:F186	5.71	1	Yes	Yes	0	1	0	1
L:L:?1	R:R:T194	6.91	1	Yes	No	0	5	0	1
R:R:F195	R:R:F199	6.43	1	Yes	Yes	5	8	2	2
R:R:F195	R:R:F268	4.29	1	Yes	Yes	5	7	2	1
R:R:F268	R:R:S198	3.96	1	Yes	No	7	6	1	1
L:L:?1	R:R:S198	9.39	1	Yes	No	0	6	0	1
R:R:F199	R:R:F268	22.51	1	Yes	Yes	8	7	2	1
R:R:F267	R:R:W264	6.01	1	Yes	Yes	5	8	1	1
R:R:F268	R:R:W264	12.03	1	Yes	Yes	7	8	1	1
R:R:G293	R:R:W264	8.44	0	No	Yes	7	8	2	1
R:R:N296	R:R:W264	10.17	1	Yes	Yes	9	8	2	1
L:L:?1	R:R:W264	8.9	1	Yes	Yes	0	8	0	1
R:R:F267	R:R:F268	9.65	1	Yes	Yes	5	7	1	1
R:R:F267	R:R:T271	9.08	1	Yes	No	5	5	1	2
R:R:F267	R:R:L289	4.87	1	Yes	No	5	5	1	2
L:L:?1	R:R:F267	13.33	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:F268	12.38	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:I290	11.16	1	Yes	No	0	5	0	1
L:L:?1	R:R:S183	3.52	1	Yes	No	0	4	0	1
L:L:?1	R:R:T100	3.46	1	Yes	No	0	4	0	1
R:R:A155	R:R:I104	3.25	0	No	No	6	4	2	1
L:L:?1	R:R:N286	3.22	1	Yes	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8ZSP_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.93
Number of Linked Nodes	269
Number of Links	299
Number of Hubs	39
Number of Links mediated by Hubs	144
Number of Communities	6
Number of Nodes involved in Communities	51
Number of Links involved in Communities	73

Path Summary
Number Of Nodes in MetaPath	75
Number Of Links MetaPath	74
Number of Shortest Paths	50794
Length Of Smallest Path	3
Average Path Length	12.6884
Length of Longest Path	27
Minimum Path Strength	1.425
Average Path Strength	7.55061
Maximum Path Strength	19.72
Minimum Path Correlation	0.7
Average Path Correlation	0.927313
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.88235
Average % Of Corr. Nodes	52.7523
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.2911
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • D1 dopamine receptor binding • dopamine receptor binding • G protein activity • molecular function regulator activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • regulation of biological process • cell population proliferation • regulation of cellular process • positive regulation of cell population proliferation • biological regulation • positive regulation of biological process • positive regulation of neural precursor cell proliferation • regulation of cell population proliferation • cellular process • neural precursor cell proliferation • positive regulation of cellular process • regulation of neural precursor cell proliferation • reactive oxygen species metabolic process • regulation of superoxide metabolic process
Gene Ontology	Biological Process	• regulation of biological process • cell population proliferation • regulation of cellular process • positive regulation of cell population proliferation • biological regulation • positive regulation of biological process • positive regulation of neural precursor cell proliferation • regulation of cell population proliferation • cellular process • neural precursor cell proliferation • positive regulation of cellular process • regulation of neural precursor cell proliferation • reactive oxygen species metabolic process • regulation of superoxide metabolic process • positive regulation of reactive oxygen species metabolic process • superoxide metabolic process • positive regulation of metabolic process • superoxide anion generation • metabolic process • positive regulation of superoxide anion generation • regulation of superoxide anion generation • regulation of metabolic process • regulation of reactive oxygen species metabolic process • regulation of calcium ion transport • regulation of localization • transport • regulation of transport • regulation of monoatomic ion transport • establishment of localization • metal ion transport • calcium ion transport • localization • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • cellular response to stimulus • positive regulation of cell communication • positive regulation of signal transduction • response to stimulus • signaling • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • signal transduction • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • negative regulation of signaling • negative regulation of biological process • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • adenylate cyclase-activating adrenergic receptor signaling pathway • negative regulation of response to stimulus • adenylate cyclase-activating G protein-coupled receptor signaling pathway • negative regulation of signal transduction • negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell division • regulation of body fluid levels • multicellular organismal process • renal system process • system process • positive regulation of urine volume • regulation of urine volume • regulation of biological quality • regulation of vascular associated smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell proliferation • regulation of smooth muscle cell proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • muscle cell proliferation • vascular associated smooth muscle cell proliferation • cell-cell signaling • gamma-aminobutyric acid signaling pathway • purinergic nucleotide receptor signaling pathway • cell surface receptor signaling pathway • G protein-coupled purinergic receptor signaling pathway • G protein-coupled adenosine receptor signaling pathway • regulation of molecular function • negative regulation of lyase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • negative regulation of molecular function • negative regulation of catalytic activity • negative regulation of adenylate cyclase activity • regulated exocytosis • regulation of calcium ion-dependent exocytosis • negative regulation of transport • negative regulation of regulated secretory pathway • vesicle-mediated transport • regulation of regulated secretory pathway • secretion by cell • regulation of secretion by cell • negative regulation of secretion • negative regulation of exocytosis • negative regulation of secretion by cell • calcium-ion regulated exocytosis • secretion • negative regulation of calcium ion-dependent exocytosis • export from cell • regulation of vesicle-mediated transport • regulation of secretion • exocytosis • regulation of exocytosis • regulation of programmed cell death • negative regulation of apoptotic signaling pathway • negative regulation of programmed cell death • regulation of apoptotic process • cell death • apoptotic signaling pathway • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of apoptotic signaling pathway • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • locomotion • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • trans-synaptic signaling • modulation of chemical synaptic transmission • negative regulation of synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • cellular response to nitrogen compound • cellular response to acetylcholine • response to oxygen-containing compound • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to chemical • response to acetylcholine • response to nutrient levels • response to nutrient • developmental process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • cellular response to endogenous stimulus • response to hormone • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of multicellular organismal process • protein localization • establishment of protein localization • nitrogen compound transport • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • regulation of protein secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • hormone secretion • protein localization to extracellular region • peptide secretion • amide transport • signal release • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • midbody • cellular anatomical structure • membrane • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • neuronal dense core vesicle • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • cytosol • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • neuron to neuron synapse • synapse • cell junction • hippocampal mossy fiber to CA3 synapse • cell body • cilium • ciliary basal body • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • G protein-coupled amine receptor activity • molecular transducer activity • trace-amine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • electron transport chain • metabolic process • generation of precursor metabolites and energy • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • periplasmic space • endoplasmic reticulum subcompartment • nuclear outer membrane-endoplasmic reticulum membrane network • endoplasmic reticulum • endoplasmic reticulum membrane
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	7LD
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	7LD
Name	Lysergic acid diethylamide
Synonyms	N,N-diethyllysergamide
Identifier
Formula	C20 H25 N3 O
Molecular Weight	323.432
SMILES
PubChem	5761
Formal Charge	0
Total Atoms	49
Total Chiral Atoms	2
Total Bonds	52
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q96RJ0
Sequence	>8ZSP_nogp_Chain_R V R A S L Y S L M V L I I L T T L V G N L I V I V S I S H F K Q L H T P T N W L I H S M A T V D F L L G C L V M P Y S M V R S A E H C W Y F G E V F C K I H T S T D I M L S S A S I F H L S F I S I D R Y Y A V C D P L R Y K A K M N I L V I C V M I F I S W S V P A V F A F G M I F L E L N F K G A E E I Y Y K H V H C R G G C S V F F S K I S G V L T F M T S F Y I P G S I M L C V Y Y R I Y L I A K E Q A R L I S D A N Q K R K A V K T L G I V M G V F L I C W C P F F I C T V M D P F L H Y I I P P T L N D V L I W F G Y L N S T F N P M V Y A F F Y P W F R K A L K M M Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9JKQ	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	METH	-	Gs/β1/γ2	2.66	2024-10-16	doi.org/10.1021/acs.jmedchem.4c01961
	9JKQ (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	METH	-		2.66	2024-10-16	doi.org/10.1021/acs.jmedchem.4c01961
	8ZSV	A	Amine	Trace Amine Receptors	TA1	Mus musculus	RO5263397	-	chim(NtGi1-Gs)/β1/γ2	2.96	2024-07-24	10.1016/j.celrep.2024.114505
	8ZSV (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	RO5263397	-		2.96	2024-07-24	10.1016/j.celrep.2024.114505
	8ZSS	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5263397	-	chim(NtGi1-Gs)/β1/γ2	3.07	2024-07-24	10.1016/j.celrep.2024.114505
	8ZSS (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5263397	-		3.07	2024-07-24	10.1016/j.celrep.2024.114505
	8ZSP	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	LSD	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.14	2024-07-24	10.1016/j.celrep.2024.114505
	8ZSP (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	LSD	-		3.14	2024-07-24	10.1016/j.celrep.2024.114505
	8ZSJ	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	-	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-07-24	10.1016/j.celrep.2024.114505
	8ZSJ (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	-	-		2.8	2024-07-24	10.1016/j.celrep.2024.114505
	8UHB	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5256390	-	Gs/β1/γ2	3.35	2024-01-10	10.1038/s41467-023-44601-4
	8UHB (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5256390	-		3.35	2024-01-10	10.1038/s41467-023-44601-4
	8WCC	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Cyclohexylammonium Ion	-	-	3.04	2023-12-27	10.1016/j.cell.2023.10.014
	8WCB	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Cyclohexylammonium Ion	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2023-12-27	10.1016/j.cell.2023.10.014
	8WCB (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Cyclohexylammonium Ion	-		3.1	2023-12-27	10.1016/j.cell.2023.10.014
	8WC9	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8651	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.2	2023-12-27	10.1016/j.cell.2023.10.014
	8WC9 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8651	-		3.2	2023-12-27	10.1016/j.cell.2023.10.014
	8WCA	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	2-Phenylethylamine	-	chim(NtGi1-Gs)/β1/γ2	3.48	2023-12-27	10.1016/j.cell.2023.10.014
	8WCA (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	2-Phenylethylamine	-		3.48	2023-12-27	10.1016/j.cell.2023.10.014
	8WC8	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	ZH8651	-	chim(NtGi1-Gs)/β1/γ2	2.9	2023-12-27	10.1016/j.cell.2023.10.014
	8WC8 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	ZH8651	-		2.9	2023-12-27	10.1016/j.cell.2023.10.014
	8WC7	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8667	-	chim(NtGi1-Gs)/β1/γ2	3.1	2023-12-27	10.1016/j.cell.2023.10.014
	8WC7 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8667	-		3.1	2023-12-27	10.1016/j.cell.2023.10.014
	8WC6	A	Amine	Trace Amine Receptors	TA1	Mus musculus	2-Phenylethylamine	-	chim(NtGi1-Gs)/β1/γ2	3.2	2023-12-27	10.1016/j.cell.2023.10.014
	8WC6 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	2-Phenylethylamine	-		3.2	2023-12-27	10.1016/j.cell.2023.10.014
	8WC5	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Tetramethylammonium Ion	-	chim(NtGi1-Gs)/β1/γ2	3.3	2023-12-27	10.1016/j.cell.2023.10.014
	8WC5 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Tetramethylammonium Ion	-		3.3	2023-12-27	10.1016/j.cell.2023.10.014
	8WC4	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8651	-	chim(NtGi1-Gs)/β1/γ2	3.1	2023-12-27	10.1016/j.cell.2023.10.014
	8WC4 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8651	-		3.1	2023-12-27	10.1016/j.cell.2023.10.014
	8WC3	A	Amine	Trace Amine Receptors	TA1	Mus musculus	SEP-363856	-	chim(NtGi1-Gs)/β1/γ2	3	2023-12-27	10.1016/j.cell.2023.10.014
	8WC3 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	SEP-363856	-		3	2023-12-27	10.1016/j.cell.2023.10.014
	8W8A	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5256390	-	chim(NtGi1L-Gs)/β1/γ2	2.8	2023-11-22	10.1038/s41586-023-06775-1
	8W8A (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5256390	-		2.8	2023-11-22	10.1038/s41586-023-06775-1
	8W89	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	PEA	-	chim(NtGi1L-Gs)/β1/γ2	3	2023-11-22	10.1038/s41586-023-06775-1
	8W89 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	PEA	-		3	2023-11-22	10.1038/s41586-023-06775-1
	8W87	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	METH	-	chim(NtGi1L-Gs)/β1/γ2	2.8	2023-11-22	10.1038/s41586-023-06775-1
	8W87 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	METH	-		2.8	2023-11-22	10.1038/s41586-023-06775-1
	8W88	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	SEP-363856	-	Gs/β1/γ2	2.6	2023-11-22	10.1038/s41586-023-06775-1
	8W88 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	SEP-363856	-		2.6	2023-11-22	10.1038/s41586-023-06775-1
	8JSO	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	AMPH	-	chim(NtGi1-Gs)/β1/γ2	3.4	2023-11-15	10.1038/s41586-023-06804-z
	8JSO (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	AMPH	-		3.4	2023-11-15	10.1038/s41586-023-06804-z
	8JLR	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	A77636	-	chim(NtGi1-Gs)/β1/γ2	3	2023-11-15	10.1038/s41586-023-06804-z
	8JLR (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	A77636	-		3	2023-11-15	10.1038/s41586-023-06804-z
	8JLK	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Ulotaront	-	chim(NtGi1-Gs)/β1/γ2	3.22	2023-11-15	10.1038/s41586-023-06804-z
	8JLK (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Ulotaront	-		3.22	2023-11-15	10.1038/s41586-023-06804-z
	8JLJ	A	Amine	Trace Amine Receptors	TA1	Mus musculus	T1AM	-	chim(NtGi1-Gs)/β1/γ2	3.1	2023-11-15	10.1038/s41586-023-06804-z
	8JLJ (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	T1AM	-		3.1	2023-11-15	10.1038/s41586-023-06804-z
	8JLQ	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Fenoldopam	-	Gs/β1/γ2	2.84	2023-11-15	10.1038/s41586-023-06804-z
	8JLQ (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Fenoldopam	-		2.84	2023-11-15	10.1038/s41586-023-06804-z
	8JLP	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Ralmitaront	-	Gs/β1/γ2	3.23	2023-11-15	10.1038/s41586-023-06804-z
	8JLP (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Ralmitaront	-		3.23	2023-11-15	10.1038/s41586-023-06804-z
	8JLO	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Ulotaront	-	Gs/β1/γ2	3.52	2023-11-15	10.1038/s41586-023-06804-z
	8JLO (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Ulotaront	-		3.52	2023-11-15	10.1038/s41586-023-06804-z
	8JLN	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	T1AM	-	Gs/β1/γ2	3.24	2023-11-15	10.1038/s41586-023-06804-z
	8JLN (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	T1AM	-		3.24	2023-11-15	10.1038/s41586-023-06804-z

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