Code7LD
NameLysergic acid diethylamide
SynonymsD-lysergic acid diethylamide
Identifier(6~{a}~{R},9~{R})-~{N},~{N}-diethyl-7-methyl-6,6~{a},8,9-tetrahydro-4~{H}-indolo[4,3-fg]quinoline-9-carboxamide
FormulaC20 H25 N3 O
Molecular Weight323.432
SMILESCCN(CC)C(=O)[C@H]1CN([C@@H]2Cc3c[nH]c4c3c(ccc4)C2=C1)C
PubChem5761
Formal Charge0
Total Atoms49
Total Chiral Atoms2
Total Bonds52
Total Aromatic Bonds10
Networks7
 missing image

This ligand is also present in the following 7 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
5TVN A Amine 5-Hydroxytryptamine 5-HT2B Homo sapiens LSD - - 2.9 2017-02-01 10.1016/j.cell.2016.12.033

A 2D representation of the interactions of 7LD in 5TVN
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D135 R:R:V107 5.84 1 Yes No 8 7 1 2
R:R:V107 R:R:Y370 3.79 1 No Yes 7 8 2 2
R:R:I110 R:R:W131 12.92 0 No Yes 5 6 2 1
R:R:T114 R:R:W131 3.64 0 No Yes 5 6 2 1
R:R:W121 R:R:W131 6.56 1 Yes Yes 7 6 2 1
R:R:C207 R:R:W121 9.14 1 Yes Yes 9 7 2 2
R:R:L132 R:R:W131 3.42 0 No Yes 5 6 2 1
R:R:C207 R:R:W131 3.92 1 Yes Yes 9 6 2 1
L:L:?1 R:R:W131 3.8 1 Yes Yes 0 6 0 1
R:R:D135 R:R:S139 4.42 1 Yes No 8 7 1 1
R:R:D135 R:R:Y370 5.75 1 Yes Yes 8 8 1 2
L:L:?1 R:R:D135 22.64 1 Yes Yes 0 8 0 1
R:R:A187 R:R:V136 3.39 0 No No 8 7 2 1
R:R:F217 R:R:V136 3.93 1 Yes No 7 7 1 1
L:L:?1 R:R:V136 13.67 1 Yes No 0 7 0 1
L:L:?1 R:R:S139 6.26 1 Yes No 0 7 0 1
R:R:F217 R:R:P189 10.11 1 Yes No 7 8 1 2
R:R:F217 R:R:V190 5.24 1 Yes No 7 6 1 2
R:R:F214 R:R:L209 9.74 1 Yes No 5 5 2 1
L:L:?1 R:R:L209 3.46 1 Yes No 0 5 0 1
R:R:F214 R:R:F217 4.29 1 Yes Yes 5 7 2 1
L:L:?1 R:R:F217 9.14 1 Yes Yes 0 7 0 1
R:R:M218 R:R:N344 8.41 0 No Yes 6 6 2 1
R:R:F341 R:R:S222 6.61 1 Yes Yes 7 7 1 1
R:R:N344 R:R:S222 4.47 1 Yes Yes 6 7 1 1
R:R:I345 R:R:S222 4.64 0 No Yes 6 7 2 1
L:L:?1 R:R:S222 3.76 1 Yes Yes 0 7 0 1
R:R:F226 R:R:F341 19.29 0 Yes Yes 8 7 2 1
R:R:F340 R:R:W337 7.02 1 Yes Yes 7 8 1 2
R:R:F341 R:R:W337 6.01 1 Yes Yes 7 8 1 2
R:R:F340 R:R:F341 13.93 1 Yes Yes 7 7 1 1
R:R:F340 R:R:N344 4.83 1 Yes Yes 7 6 1 1
L:L:?1 R:R:F340 24.38 1 Yes Yes 0 7 0 1
L:L:?1 R:R:F341 8.13 1 Yes Yes 0 7 0 1
R:R:L362 R:R:N344 5.49 0 No Yes 5 6 2 1
L:L:?1 R:R:N344 5.73 1 Yes Yes 0 6 0 1
R:R:V366 R:R:W367 3.68 1 No Yes 6 7 1 2
R:R:V366 R:R:Y370 10.09 1 No Yes 6 8 1 2
L:L:?1 R:R:V366 6.21 1 Yes No 0 6 0 1
R:R:W367 R:R:Y370 7.72 1 Yes Yes 7 8 2 2
L:L:?1 R:R:G221 1.43 1 Yes No 0 6 0 1
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub7.00
Average Interaction Strength9.05
Average Nodes In Shell30.00
Average Hubs In Shell15.00
Average Links In Shell41.00
Average Links Mediated by Hubs In Shell40.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6WGT A Amine 5-Hydroxytryptamine 5-HT2A Homo sapiens LSD - - 3.4 2020-09-23 10.1016/j.cell.2020.08.024

A 2D representation of the interactions of 7LD in 6WGT
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:V127 R:R:W151 3.68 1 Yes Yes 8 5 2 1
R:R:D155 R:R:V127 5.84 1 Yes Yes 8 8 1 2
R:R:V127 R:R:Y370 3.79 1 Yes Yes 8 7 2 2
R:R:V130 R:R:W151 14.71 0 No Yes 4 5 2 1
R:R:W141 R:R:W151 10.31 3 Yes Yes 7 5 2 1
L:L:?1 R:R:W151 4.75 1 Yes Yes 0 5 0 1
R:R:I152 R:R:I210 4.42 0 No Yes 5 6 2 2
R:R:I152 R:R:L229 7.14 0 No No 5 4 2 1
R:R:D155 R:R:V156 4.38 1 Yes No 8 6 1 1
R:R:D155 R:R:S159 4.42 1 Yes No 8 7 1 1
R:R:D155 R:R:Y370 4.6 1 Yes Yes 8 7 1 2
L:L:?1 R:R:D155 24.91 1 Yes Yes 0 8 0 1
R:R:I210 R:R:V156 4.61 1 Yes No 6 6 2 1
L:L:?1 R:R:V156 18.64 1 Yes No 0 6 0 1
L:L:?1 R:R:S159 10.02 1 Yes No 0 7 0 1
R:R:S242 R:R:T160 7.99 0 No No 6 7 1 2
R:R:F234 R:R:I210 7.54 0 Yes Yes 7 6 2 2
R:R:K223 R:R:L228 5.64 0 No No 3 4 2 1
R:R:L228 R:R:S226 4.5 0 No No 4 4 1 2
R:R:F234 R:R:L229 6.09 0 Yes No 7 4 2 1
L:L:?1 R:R:L229 5.77 1 Yes No 0 4 0 1
R:R:F234 R:R:G238 4.52 0 Yes No 7 6 2 1
R:R:N343 R:R:V235 5.91 1 Yes No 7 6 1 2
R:R:G238 R:R:I237 3.53 0 No No 6 4 1 2
L:L:?1 R:R:G238 4.28 1 Yes No 0 6 0 1
R:R:F340 R:R:S239 7.93 1 Yes No 7 6 1 1
R:R:I344 R:R:S239 3.1 0 No No 5 6 2 1
L:L:?1 R:R:S239 8.77 1 Yes No 0 6 0 1
L:L:?1 R:R:S242 5.01 1 Yes No 0 6 0 1
R:R:F243 R:R:F340 21.43 0 No Yes 8 7 2 1
R:R:F339 R:R:W336 7.02 1 Yes Yes 7 8 1 2
R:R:F340 R:R:W336 9.02 1 Yes Yes 7 8 1 2
R:R:W336 R:R:Y370 3.86 1 Yes Yes 8 7 2 2
R:R:F339 R:R:F340 12.86 1 Yes Yes 7 7 1 1
R:R:F339 R:R:N343 13.29 1 Yes Yes 7 7 1 1
R:R:F339 R:R:L362 3.65 1 Yes No 7 3 1 2
R:R:F339 R:R:V366 6.55 1 Yes Yes 7 6 1 1
L:L:?1 R:R:F339 14.22 1 Yes Yes 0 7 0 1
L:L:?1 R:R:F340 10.16 1 Yes Yes 0 7 0 1
R:R:L362 R:R:N343 4.12 1 No Yes 3 7 2 1
L:L:?1 R:R:N343 5.73 1 Yes Yes 0 7 0 1
R:R:V366 R:R:W367 3.68 1 Yes Yes 6 6 1 2
R:R:V366 R:R:Y370 8.83 1 Yes Yes 6 7 1 2
L:L:?1 R:R:V366 3.73 1 Yes Yes 0 6 0 1
R:R:W367 R:R:Y370 12.54 1 Yes Yes 6 7 2 2
L:L:?1 R:R:L228 2.31 1 Yes No 0 4 0 1
R:R:S242 R:R:V241 1.62 0 No No 6 4 1 2
StatisticsValue
Average Number Of Links13.00
Average Number Of Links With An Hub6.00
Average Interaction Strength9.10
Average Nodes In Shell32.00
Average Hubs In Shell14.00
Average Links In Shell47.00
Average Links Mediated by Hubs In Shell40.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6WGT_poly A Amine 5-Hydroxytryptamine 5-HT2A Homo sapiens LSD - - 3.4 2020-09-23 10.1016/j.cell.2020.08.024

A 2D representation of the interactions of 7LD in 6WGT_poly
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
S:S:L123 S:S:V127 4.47 2 Yes Yes 7 8 2 2
S:S:D155 S:S:L123 2.71 2 Yes Yes 8 7 1 2
S:S:L123 S:S:S159 4.5 2 Yes No 7 7 2 1
S:S:L123 S:S:Y370 5.86 2 Yes Yes 7 7 2 1
S:S:V127 S:S:W151 6.13 2 Yes Yes 8 5 2 1
S:S:D155 S:S:V127 8.76 2 Yes Yes 8 8 1 2
S:S:V127 S:S:Y370 5.05 2 Yes Yes 8 7 2 1
S:S:M128 S:S:W367 4.65 2 Yes Yes 8 6 2 2
S:S:M128 S:S:Y370 11.97 2 Yes Yes 8 7 2 1
S:S:V130 S:S:W141 3.68 2 Yes Yes 4 7 2 2
S:S:V130 S:S:W151 17.16 2 Yes Yes 4 5 2 1
S:S:S131 S:S:W151 4.94 2 No Yes 7 5 2 1
S:S:S131 S:S:W367 7.41 2 No Yes 7 6 2 2
S:S:S131 S:S:Y370 6.36 2 No Yes 7 7 2 1
S:S:W141 S:S:W151 12.18 2 Yes Yes 7 5 2 1
S:S:C227 S:S:W141 18.28 2 No Yes 9 7 2 2
S:S:C227 S:S:W151 5.22 2 No Yes 9 5 2 1
M:M:?1 S:S:W151 8.55 2 Yes Yes 0 5 0 1
S:S:I152 S:S:L229 7.14 0 No Yes 5 4 2 1
S:S:D155 S:S:S159 4.42 2 Yes No 8 7 1 1
S:S:D155 S:S:Y370 10.34 2 Yes Yes 8 7 1 1
M:M:?1 S:S:D155 18.11 2 Yes Yes 0 8 0 1
S:S:S207 S:S:V156 4.85 0 No No 7 6 2 1
S:S:I210 S:S:V156 4.61 2 Yes No 6 6 2 1
M:M:?1 S:S:V156 17.4 2 Yes No 0 6 0 1
M:M:?1 S:S:S159 3.76 2 Yes No 0 7 0 1
S:S:S242 S:S:T160 6.4 0 No Yes 6 7 1 2
S:S:F234 S:S:P209 4.33 2 Yes No 7 7 1 2
S:S:I210 S:S:L229 2.85 2 Yes Yes 6 4 2 1
S:S:F234 S:S:I210 8.79 2 Yes Yes 7 6 1 2
S:S:D231 S:S:F213 11.94 2 No Yes 5 4 2 2
S:S:F213 S:S:F234 4.29 2 Yes Yes 4 7 2 1
S:S:F234 S:S:L229 4.87 2 Yes Yes 7 4 1 1
S:S:L229 S:S:V235 5.96 2 Yes No 4 6 1 2
M:M:?1 S:S:L229 6.93 2 Yes Yes 0 4 0 1
S:S:D231 S:S:F234 4.78 2 No Yes 5 7 2 1
M:M:?1 S:S:F234 3.05 2 Yes Yes 0 7 0 1
S:S:N343 S:S:V235 5.91 2 Yes No 7 6 1 2
S:S:G238 S:S:S242 1.86 0 No No 6 6 2 1
S:S:F244 S:S:S239 2.64 2 Yes No 5 6 2 2
S:S:N343 S:S:S239 4.47 2 Yes No 7 6 1 2
M:M:?1 S:S:S242 6.26 2 Yes No 0 6 0 1
S:S:F243 S:S:F244 10.72 2 Yes Yes 8 5 2 2
S:S:F243 S:S:W336 3.01 2 Yes Yes 8 8 2 1
S:S:F243 S:S:F340 23.58 2 Yes Yes 8 7 2 1
S:S:F244 S:S:F340 2.14 2 Yes Yes 5 7 2 1
S:S:F332 S:S:W336 8.02 2 Yes Yes 9 8 2 1
S:S:F332 S:S:S372 6.61 2 Yes Yes 9 9 2 2
S:S:F339 S:S:W336 7.02 2 Yes Yes 7 8 1 1
S:S:F340 S:S:W336 9.02 2 Yes Yes 7 8 1 1
S:S:V366 S:S:W336 2.45 2 Yes Yes 6 8 1 1
S:S:G369 S:S:W336 11.26 0 No Yes 7 8 2 1
S:S:W336 S:S:Y370 1.93 2 Yes Yes 8 7 1 1
S:S:S372 S:S:W336 6.18 2 Yes Yes 9 8 2 1
M:M:?1 S:S:W336 2.85 2 Yes Yes 0 8 0 1
S:S:F339 S:S:F340 7.5 2 Yes Yes 7 7 1 1
S:S:F339 S:S:N343 4.83 2 Yes Yes 7 7 1 1
S:S:F339 S:S:L362 4.87 2 Yes Yes 7 3 1 2
S:S:F339 S:S:V366 9.18 2 Yes Yes 7 6 1 1
M:M:?1 S:S:F339 22.35 2 Yes Yes 0 7 0 1
M:M:?1 S:S:F340 11.18 2 Yes Yes 0 7 0 1
S:S:L362 S:S:N343 5.49 2 Yes Yes 3 7 2 1
M:M:?1 S:S:N343 3.44 2 Yes Yes 0 7 0 1
S:S:V366 S:S:Y370 7.57 2 Yes Yes 6 7 1 1
M:M:?1 S:S:V366 2.49 2 Yes Yes 0 6 0 1
S:S:W367 S:S:Y370 20.26 2 Yes Yes 6 7 2 1
M:M:?1 S:S:Y370 2.93 2 Yes Yes 0 7 0 1
StatisticsValue
Average Number Of Links13.00
Average Number Of Links With An Hub10.00
Average Interaction Strength8.41
Average Nodes In Shell38.00
Average Hubs In Shell25.00
Average Links In Shell67.00
Average Links Mediated by Hubs In Shell65.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)

A 2D representation of the interactions of 7LD in 6WGT_poly
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:V127 R:R:W151 3.68 1 Yes Yes 8 5 2 1
R:R:D155 R:R:V127 5.84 1 Yes Yes 8 8 1 2
R:R:V127 R:R:Y370 3.79 1 Yes Yes 8 7 2 1
R:R:M128 R:R:W367 2.33 1 Yes Yes 8 6 2 2
R:R:M128 R:R:Y370 13.17 1 Yes Yes 8 7 2 1
R:R:V130 R:R:W141 2.45 1 Yes Yes 4 7 2 2
R:R:V130 R:R:W151 14.71 1 Yes Yes 4 5 2 1
R:R:S131 R:R:W367 9.88 1 No Yes 7 6 2 2
R:R:S131 R:R:Y370 2.54 1 No Yes 7 7 2 1
R:R:W141 R:R:W151 10.31 1 Yes Yes 7 5 2 1
R:R:C227 R:R:W141 15.67 1 Yes Yes 9 7 2 2
R:R:I152 R:R:W151 2.35 1 Yes Yes 5 5 2 1
R:R:C227 R:R:W151 2.61 1 Yes Yes 9 5 2 1
L:L:?1 R:R:W151 4.75 1 Yes Yes 0 5 0 1
R:R:I152 R:R:V156 1.54 1 Yes Yes 5 6 2 1
R:R:I152 R:R:I210 4.42 1 Yes Yes 5 6 2 2
R:R:C227 R:R:I152 1.64 1 Yes Yes 9 5 2 2
R:R:I152 R:R:L229 7.14 1 Yes Yes 5 4 2 1
R:R:D155 R:R:V156 4.38 1 Yes Yes 8 6 1 1
R:R:D155 R:R:S159 4.42 1 Yes No 8 7 1 1
R:R:D155 R:R:Y370 4.6 1 Yes Yes 8 7 1 1
L:L:?1 R:R:D155 24.91 1 Yes Yes 0 8 0 1
R:R:S207 R:R:V156 1.62 1 Yes Yes 7 6 2 1
R:R:I210 R:R:V156 4.61 1 Yes Yes 6 6 2 1
L:L:?1 R:R:V156 18.64 1 Yes Yes 0 6 0 1
L:L:?1 R:R:S159 10.02 1 Yes No 0 7 0 1
R:R:M164 R:R:T160 1.51 0 No Yes 6 7 2 1
R:R:S203 R:R:T160 7.99 0 No Yes 8 7 2 1
R:R:S242 R:R:T160 7.99 1 Yes Yes 6 7 1 1
L:L:?1 R:R:T160 2.46 1 Yes Yes 0 7 0 1
R:R:F234 R:R:I210 7.54 1 Yes Yes 7 6 1 2
R:R:K223 R:R:L228 5.64 0 No No 3 4 2 1
R:R:L228 R:R:S226 4.5 0 No No 4 4 1 2
L:L:?1 R:R:L228 2.31 1 Yes No 0 4 0 1
R:R:F234 R:R:L229 6.09 1 Yes Yes 7 4 1 1
R:R:L229 R:R:V235 2.98 1 Yes No 4 6 1 2
L:L:?1 R:R:L229 5.77 1 Yes Yes 0 4 0 1
R:R:D231 R:R:F234 2.39 0 No Yes 5 7 2 1
R:R:F234 R:R:G238 4.52 1 Yes Yes 7 6 1 1
L:L:?1 R:R:F234 2.03 1 Yes Yes 0 7 0 1
R:R:N343 R:R:V235 5.91 1 Yes No 7 6 1 2
R:R:G238 R:R:I237 3.53 1 Yes No 6 4 1 2
R:R:I237 R:R:V241 1.54 0 No No 4 4 2 2
R:R:G238 R:R:S242 1.86 1 Yes Yes 6 6 1 1
L:L:?1 R:R:G238 4.28 1 Yes Yes 0 6 0 1
R:R:F340 R:R:S239 7.93 1 Yes Yes 7 6 1 1
R:R:N343 R:R:S239 2.98 1 Yes Yes 7 6 1 1
R:R:I344 R:R:S239 3.1 0 No Yes 5 6 2 1
L:L:?1 R:R:S239 8.77 1 Yes Yes 0 6 0 1
R:R:S242 R:R:V241 1.62 1 Yes No 6 4 1 2
L:L:?1 R:R:S242 5.01 1 Yes Yes 0 6 0 1
R:R:F243 R:R:F244 12.86 1 Yes Yes 8 5 2 2
R:R:F243 R:R:W336 3.01 1 Yes Yes 8 8 2 1
R:R:F243 R:R:F340 21.43 1 Yes Yes 8 7 2 1
R:R:F244 R:R:F340 2.14 1 Yes Yes 5 7 2 1
R:R:F332 R:R:W336 7.02 1 Yes Yes 9 8 2 1
R:R:F332 R:R:S372 3.96 1 Yes Yes 9 9 2 2
R:R:F339 R:R:W336 7.02 1 Yes Yes 7 8 1 1
R:R:F340 R:R:W336 9.02 1 Yes Yes 7 8 1 1
R:R:G369 R:R:W336 12.67 1 No Yes 7 8 2 1
R:R:W336 R:R:Y370 3.86 1 Yes Yes 8 7 1 1
R:R:S372 R:R:W336 4.94 1 Yes Yes 9 8 2 1
L:L:?1 R:R:W336 2.85 1 Yes Yes 0 8 0 1
R:R:F339 R:R:F340 12.86 1 Yes Yes 7 7 1 1
R:R:F339 R:R:N343 13.29 1 Yes Yes 7 7 1 1
R:R:F339 R:R:L362 3.65 1 Yes Yes 7 3 1 2
R:R:F339 R:R:V366 6.55 1 Yes Yes 7 6 1 1
L:L:?1 R:R:F339 14.22 1 Yes Yes 0 7 0 1
L:L:?1 R:R:F340 10.16 1 Yes Yes 0 7 0 1
R:R:A346 R:R:N343 1.56 0 No Yes 4 7 2 1
R:R:L362 R:R:N343 4.12 1 Yes Yes 3 7 2 1
L:L:?1 R:R:N343 5.73 1 Yes Yes 0 7 0 1
R:R:V366 R:R:W367 3.68 1 Yes Yes 6 6 1 2
R:R:V366 R:R:Y370 8.83 1 Yes Yes 6 7 1 1
L:L:?1 R:R:V366 3.73 1 Yes Yes 0 6 0 1
R:R:W367 R:R:Y370 12.54 1 Yes Yes 6 7 2 1
L:L:?1 R:R:Y370 1.96 1 Yes Yes 0 7 0 1
StatisticsValue
Average Number Of Links17.00
Average Number Of Links With An Hub15.00
Average Interaction Strength7.51
Average Nodes In Shell44.00
Average Hubs In Shell30.00
Average Links In Shell77.00
Average Links Mediated by Hubs In Shell74.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7SRQ A Amine 5-Hydroxytryptamine 5-HT2B Homo sapiens LSD - - 2.7 2022-09-21 10.1016/j.neuron.2022.08.006

A 2D representation of the interactions of 7LD in 7SRQ
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:V107 R:R:W131 4.9 1 No Yes 7 6 2 2
R:R:D135 R:R:V107 5.84 1 Yes No 8 7 1 2
R:R:V107 R:R:Y370 3.79 1 No Yes 7 8 2 2
R:R:D135 R:R:W131 3.35 1 Yes Yes 8 6 1 2
R:R:D135 R:R:Y370 6.9 1 Yes Yes 8 8 1 2
L:L:?1 R:R:D135 15.85 1 Yes Yes 0 8 0 1
R:R:A187 R:R:V136 3.39 7 No No 8 7 2 1
L:L:?1 R:R:V136 6.21 1 Yes No 0 7 0 1
R:R:A225 R:R:T140 3.36 1 No No 7 7 1 1
L:L:?1 R:R:T140 3.69 1 Yes No 0 7 0 1
R:R:M218 R:R:N344 7.01 0 No No 6 6 2 1
R:R:F341 R:R:S222 3.96 0 Yes No 7 7 2 2
R:R:N344 R:R:S222 4.47 0 No No 6 7 1 2
L:L:?1 R:R:A225 2.63 1 Yes No 0 7 0 1
R:R:F340 R:R:F341 9.65 1 Yes Yes 7 7 1 2
R:R:F340 R:R:L362 3.65 1 Yes No 7 5 1 2
R:R:F340 R:R:V366 3.93 1 Yes No 7 6 1 1
L:L:?1 R:R:F340 21.33 1 Yes Yes 0 7 0 1
L:L:?1 R:R:N344 3.44 1 Yes No 0 6 0 1
R:R:V366 R:R:Y370 5.05 1 No Yes 6 8 1 2
L:L:?1 R:R:V366 11.18 1 Yes No 0 6 0 1
L:L:?1 R:R:S139 2.5 1 Yes No 0 7 0 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub2.00
Average Interaction Strength8.35
Average Nodes In Shell17.00
Average Hubs In Shell6.00
Average Links In Shell22.00
Average Links Mediated by Hubs In Shell18.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7SRR A Amine 5-Hydroxytryptamine 5-HT2B Homo sapiens LSD - chim(NtGi2L-Gs-CtGq)/Beta1/Gamma2 2.9 2022-09-21 10.1016/j.neuron.2022.08.006

A 2D representation of the interactions of 7LD in 7SRR
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:V107 R:R:W131 6.13 5 No Yes 7 6 2 1
R:R:D135 R:R:V107 2.92 5 Yes No 8 7 1 2
R:R:V107 R:R:Y370 3.79 5 No Yes 7 8 2 2
R:R:I110 R:R:W131 7.05 0 No Yes 5 6 2 1
R:R:W121 R:R:W131 4.69 13 Yes Yes 7 6 2 1
L:L:?1 R:R:W131 2.85 5 Yes Yes 0 6 0 1
R:R:D135 R:R:S139 4.42 5 Yes No 8 7 1 1
R:R:D135 R:R:Y370 10.34 5 Yes Yes 8 8 1 2
L:L:?1 R:R:D135 19.24 5 Yes Yes 0 8 0 1
R:R:A187 R:R:V136 3.39 0 No No 8 7 2 1
L:L:?1 R:R:V136 16.15 5 Yes No 0 7 0 1
R:R:S139 R:R:W337 2.47 5 No Yes 7 8 1 2
L:L:?1 R:R:S139 6.26 5 Yes No 0 7 0 1
R:R:A225 R:R:T140 3.36 0 No Yes 7 7 1 2
R:R:F217 R:R:V190 3.93 0 No No 7 6 1 2
R:R:F217 R:R:G221 3.01 0 No No 7 6 1 2
L:L:?1 R:R:F217 3.05 5 Yes No 0 7 0 1
R:R:M218 R:R:N344 7.01 0 No No 6 6 2 1
L:L:?1 R:R:A225 2.63 5 Yes No 0 7 0 1
R:R:F341 R:R:W337 8.02 5 Yes Yes 7 8 2 2
R:R:F340 R:R:F341 5.36 5 Yes Yes 7 7 1 2
R:R:F340 R:R:L362 4.87 5 Yes No 7 5 1 2
R:R:F340 R:R:V366 3.93 5 Yes No 7 6 1 1
L:L:?1 R:R:F340 16.26 5 Yes Yes 0 7 0 1
R:R:V366 R:R:Y370 6.31 5 No Yes 6 8 1 2
L:L:?1 R:R:V366 4.97 5 Yes No 0 6 0 1
L:L:?1 R:R:N344 2.29 5 Yes No 0 6 0 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub3.00
Average Interaction Strength8.19
Average Nodes In Shell22.00
Average Hubs In Shell9.00
Average Links In Shell27.00
Average Links Mediated by Hubs In Shell23.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7SRS A Amine 5-Hydroxytryptamine 5-HT2B Homo sapiens LSD - Arrestin2 3.3 2022-09-21 10.1016/j.neuron.2022.08.006

A 2D representation of the interactions of 7LD in 7SRS
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:V107 R:R:W131 3.68 2 No Yes 7 6 2 1
R:R:D135 R:R:V107 2.92 2 No No 8 7 1 2
R:R:V107 R:R:Y370 5.05 2 No Yes 7 8 2 2
R:R:I110 R:R:W131 12.92 0 No Yes 5 6 2 1
R:R:L132 R:R:W131 2.28 0 No Yes 5 6 2 1
L:L:?1 R:R:W131 1.9 2 Yes Yes 0 6 0 1
R:R:D135 R:R:Y370 6.9 2 No Yes 8 8 1 2
L:L:?1 R:R:D135 12.45 2 Yes No 0 8 0 1
L:L:?1 R:R:S139 3.76 2 Yes No 0 7 0 1
R:R:A225 R:R:T140 3.36 0 No Yes 7 7 1 2
R:R:F341 R:R:S222 3.96 2 Yes No 7 7 1 2
R:R:N344 R:R:S222 4.47 2 No No 6 7 1 2
L:L:?1 R:R:A225 2.63 2 Yes No 0 7 0 1
R:R:F226 R:R:W337 4.01 2 Yes Yes 8 8 2 2
R:R:F226 R:R:F341 17.15 2 Yes Yes 8 7 2 1
R:R:F341 R:R:W337 3.01 2 Yes Yes 7 8 1 2
R:R:F340 R:R:F341 7.5 2 Yes Yes 7 7 1 1
R:R:F340 R:R:N344 2.42 2 Yes No 7 6 1 1
R:R:F340 R:R:L362 8.53 2 Yes No 7 5 1 2
R:R:F340 R:R:F365 2.14 2 Yes No 7 5 1 2
R:R:F340 R:R:V366 2.62 2 Yes Yes 7 6 1 1
L:L:?1 R:R:F340 11.18 2 Yes Yes 0 7 0 1
L:L:?1 R:R:F341 7.11 2 Yes Yes 0 7 0 1
L:L:?1 R:R:N344 2.29 2 Yes No 0 6 0 1
R:R:V366 R:R:W367 3.68 2 Yes Yes 6 7 1 2
R:R:V366 R:R:Y370 5.05 2 Yes Yes 6 8 1 2
L:L:?1 R:R:V366 2.49 2 Yes Yes 0 6 0 1
R:R:W367 R:R:Y370 7.72 2 Yes Yes 7 8 2 2
L:L:?1 R:R:G221 1.43 2 Yes No 0 6 0 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub4.00
Average Interaction Strength5.03
Average Nodes In Shell21.00
Average Hubs In Shell10.00
Average Links In Shell29.00
Average Links Mediated by Hubs In Shell27.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7WC6 A Amine 5-Hydroxytryptamine 5-HT2A Homo sapiens LSD - - 2.6 2022-01-26 10.1126/science.abl8615

A 2D representation of the interactions of 7LD in 7WC6
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D155 R:R:V127 7.3 1 Yes No 8 8 1 2
R:R:V127 R:R:Y370 3.79 1 No Yes 8 7 2 1
R:R:M128 R:R:W367 5.82 1 Yes Yes 8 6 2 2
R:R:M128 R:R:Y370 10.78 1 Yes Yes 8 7 2 1
R:R:V130 R:R:W151 12.26 0 No Yes 4 5 2 1
R:R:S131 R:R:W367 7.41 1 No Yes 7 6 2 2
R:R:S131 R:R:Y370 5.09 1 No Yes 7 7 2 1
R:R:W141 R:R:W151 9.37 1 Yes Yes 7 5 2 1
R:R:C227 R:R:W141 13.06 1 No Yes 9 7 2 2
R:R:C227 R:R:W151 5.22 1 No Yes 9 5 2 1
L:L:?1 R:R:W151 15.2 1 Yes Yes 0 5 0 1
R:R:D155 R:R:S159 4.42 1 Yes No 8 7 1 1
R:R:D155 R:R:Y370 4.6 1 Yes Yes 8 7 1 1
L:L:?1 R:R:D155 28.3 1 Yes Yes 0 8 0 1
R:R:I210 R:R:V156 4.61 0 No No 6 6 2 1
L:L:?1 R:R:V156 14.91 1 Yes No 0 6 0 1
L:L:?1 R:R:S159 6.26 1 Yes No 0 7 0 1
R:R:S242 R:R:T160 9.59 0 No No 6 7 1 2
R:R:L229 R:R:V235 4.47 0 No No 4 6 2 1
L:L:?1 R:R:G238 4.28 1 Yes No 0 6 0 1
R:R:F340 R:R:S239 3.96 1 Yes No 7 6 1 2
R:R:F243 R:R:F340 26.79 0 No Yes 8 7 2 1
R:R:F339 R:R:W336 6.01 1 Yes Yes 7 8 1 2
R:R:F340 R:R:W336 6.01 1 Yes Yes 7 8 1 2
R:R:W336 R:R:Y370 3.86 1 Yes Yes 8 7 2 1
R:R:F339 R:R:F340 9.65 1 Yes Yes 7 7 1 1
R:R:F339 R:R:N343 9.67 1 Yes No 7 7 1 1
R:R:F339 R:R:L362 4.87 1 Yes Yes 7 3 1 2
R:R:F339 R:R:V366 5.24 1 Yes No 7 6 1 1
L:L:?1 R:R:F339 17.27 1 Yes Yes 0 7 0 1
L:L:?1 R:R:F340 11.18 1 Yes Yes 0 7 0 1
R:R:L362 R:R:N343 5.49 1 Yes No 3 7 2 1
L:L:?1 R:R:N343 4.58 1 Yes No 0 7 0 1
R:R:V366 R:R:Y370 8.83 1 No Yes 6 7 1 1
L:L:?1 R:R:V366 9.94 1 Yes No 0 6 0 1
R:R:W367 R:R:Y370 18.33 1 Yes Yes 6 7 2 1
L:L:?1 R:R:Y370 3.91 1 Yes Yes 0 7 0 1
L:L:?1 R:R:S242 3.76 1 Yes No 0 6 0 1
L:L:?1 R:R:V235 3.73 1 Yes No 0 6 0 1
R:R:G238 R:R:I237 1.76 0 No No 6 4 1 2
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub5.00
Average Interaction Strength10.28
Average Nodes In Shell28.00
Average Hubs In Shell11.00
Average Links In Shell40.00
Average Links Mediated by Hubs In Shell36.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links11.62
Average Number Of Links With An Hub6.50
Average Interaction Strength8.24
Average Nodes In Shell29.00
Average Hubs In Shell15.00
Average Links In Shell43.75
Average Links Mediated by Hubs In Shell40.38

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)