Code7LD
NameLysergic acid diethylamide
SynonymsN,N-diethyllysergamide
Identifier
FormulaC20 H25 N3 O
Molecular Weight323.432
SMILES
PubChem5761
Formal Charge0
Total Atoms49
Total Chiral Atoms2
Total Bonds52
Total Aromatic Bonds10
Networks13
 missing image

This ligand is also present in the following 13 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
5TVN A Amine 5-Hydroxytryptamine 5-HT2B Homo Sapiens LSD - - 2.9 2017-02-01 10.1016/j.cell.2016.12.033

A 2D representation of the interactions of 7LD in 5TVN
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:W131 3.8 1 Yes Yes 0 6 0 1
L:L:?1 R:R:D135 22.64 1 Yes Yes 0 8 0 1
L:L:?1 R:R:V136 13.67 1 Yes No 0 7 0 1
L:L:?1 R:R:S139 6.26 1 Yes No 0 7 0 1
L:L:?1 R:R:L209 3.46 1 Yes No 0 5 0 1
L:L:?1 R:R:F217 9.14 1 Yes Yes 0 7 0 1
L:L:?1 R:R:S222 3.76 1 Yes Yes 0 7 0 1
L:L:?1 R:R:F340 24.38 1 Yes Yes 0 7 0 1
L:L:?1 R:R:F341 8.13 1 Yes Yes 0 7 0 1
L:L:?1 R:R:N344 5.73 1 Yes Yes 0 6 0 1
L:L:?1 R:R:V366 6.21 1 Yes No 0 6 0 1
R:R:D135 R:R:V107 5.84 1 Yes No 8 7 1 2
R:R:V107 R:R:Y370 3.79 1 No Yes 7 8 2 2
R:R:I110 R:R:W131 12.92 0 No Yes 5 6 2 1
R:R:T114 R:R:W131 3.64 0 No Yes 5 6 2 1
R:R:W121 R:R:W131 6.56 1 Yes Yes 7 6 2 1
R:R:C207 R:R:W121 9.14 1 No Yes 9 7 2 2
R:R:L132 R:R:W131 3.42 0 No Yes 5 6 2 1
R:R:C207 R:R:W131 3.92 1 No Yes 9 6 2 1
R:R:D135 R:R:S139 4.42 1 Yes No 8 7 1 1
R:R:D135 R:R:Y370 5.75 1 Yes Yes 8 8 1 2
R:R:A187 R:R:V136 3.39 0 No No 8 7 2 1
R:R:F217 R:R:V136 3.93 1 Yes No 7 7 1 1
R:R:F217 R:R:P189 10.11 1 Yes No 7 8 1 2
R:R:F217 R:R:V190 5.24 1 Yes No 7 6 1 2
R:R:F214 R:R:L209 9.74 1 Yes No 5 5 2 1
R:R:F214 R:R:F217 4.29 1 Yes Yes 5 7 2 1
R:R:M218 R:R:N344 8.41 0 No Yes 6 6 2 1
R:R:F341 R:R:S222 6.61 1 Yes Yes 7 7 1 1
R:R:N344 R:R:S222 4.47 1 Yes Yes 6 7 1 1
R:R:I345 R:R:S222 4.64 0 No Yes 6 7 2 1
R:R:F226 R:R:F341 19.29 0 Yes Yes 8 7 2 1
R:R:F340 R:R:W337 7.02 1 Yes Yes 7 8 1 2
R:R:F341 R:R:W337 6.01 1 Yes Yes 7 8 1 2
R:R:F340 R:R:F341 13.93 1 Yes Yes 7 7 1 1
R:R:F340 R:R:N344 4.83 1 Yes Yes 7 6 1 1
R:R:L362 R:R:N344 5.49 0 No Yes 5 6 2 1
R:R:V366 R:R:W367 3.68 1 No Yes 6 7 1 2
R:R:V366 R:R:Y370 10.09 1 No Yes 6 8 1 2
R:R:W367 R:R:Y370 7.72 1 Yes Yes 7 8 2 2
L:L:?1 R:R:G221 1.43 1 Yes No 0 6 0 1
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub7.00
Average Interaction Strength9.05
Average Nodes In Shell30.00
Average Hubs In Shell14.00
Average Links In Shell41.00
Average Links Mediated by Hubs In Shell40.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6WGT A Amine 5-Hydroxytryptamine 5-HT2A Homo Sapiens LSD - - 3.4 2020-09-23 10.1016/j.cell.2020.08.024

A 2D representation of the interactions of 7LD in 6WGT
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:W151 4.75 1 Yes Yes 0 5 0 1
L:L:?1 R:R:D155 24.91 1 Yes Yes 0 8 0 1
L:L:?1 R:R:V156 18.64 1 Yes Yes 0 6 0 1
L:L:?1 R:R:S159 10.02 1 Yes No 0 7 0 1
L:L:?1 R:R:L229 5.77 1 Yes No 0 4 0 1
L:L:?1 R:R:G238 4.28 1 Yes No 0 6 0 1
L:L:?1 R:R:S239 8.77 1 Yes No 0 6 0 1
L:L:?1 R:R:S242 5.01 1 Yes No 0 6 0 1
L:L:?1 R:R:F339 14.22 1 Yes Yes 0 7 0 1
L:L:?1 R:R:F340 10.16 1 Yes Yes 0 7 0 1
L:L:?1 R:R:N343 5.73 1 Yes Yes 0 7 0 1
L:L:?1 R:R:V366 3.73 1 Yes Yes 0 6 0 1
R:R:V127 R:R:W151 3.68 1 Yes Yes 8 5 2 1
R:R:D155 R:R:V127 5.84 1 Yes Yes 8 8 1 2
R:R:V127 R:R:Y370 3.79 1 Yes Yes 8 7 2 2
R:R:V130 R:R:W151 14.71 0 No Yes 4 5 2 1
R:R:W141 R:R:W151 10.31 2 Yes Yes 7 5 2 1
R:R:I152 R:R:I210 4.42 0 No Yes 5 6 2 2
R:R:I152 R:R:L229 7.14 0 No No 5 4 2 1
R:R:D155 R:R:V156 4.38 1 Yes Yes 8 6 1 1
R:R:D155 R:R:S159 4.42 1 Yes No 8 7 1 1
R:R:D155 R:R:Y370 4.6 1 Yes Yes 8 7 1 2
R:R:S207 R:R:V156 3.23 0 No Yes 7 6 2 1
R:R:I210 R:R:V156 4.61 1 Yes Yes 6 6 2 1
R:R:S242 R:R:T160 7.99 0 No No 6 7 1 2
R:R:F234 R:R:I210 7.54 0 Yes Yes 7 6 2 2
R:R:K223 R:R:L228 5.64 0 No No 3 4 2 1
R:R:L228 R:R:S226 4.5 0 No No 4 4 1 2
R:R:F234 R:R:L229 6.09 0 Yes No 7 4 2 1
R:R:F234 R:R:G238 4.52 0 Yes No 7 6 2 1
R:R:N343 R:R:V235 5.91 1 Yes No 7 6 1 2
R:R:G238 R:R:I237 3.53 0 No No 6 4 1 2
R:R:F340 R:R:S239 7.93 1 Yes No 7 6 1 1
R:R:I344 R:R:S239 3.1 0 No No 5 6 2 1
R:R:F243 R:R:F340 21.43 0 No Yes 8 7 2 1
R:R:F339 R:R:W336 7.02 1 Yes Yes 7 8 1 2
R:R:F340 R:R:W336 9.02 1 Yes Yes 7 8 1 2
R:R:W336 R:R:Y370 3.86 1 Yes Yes 8 7 2 2
R:R:F339 R:R:F340 12.86 1 Yes Yes 7 7 1 1
R:R:F339 R:R:N343 13.29 1 Yes Yes 7 7 1 1
R:R:F339 R:R:L362 3.65 1 Yes No 7 3 1 2
R:R:F339 R:R:V366 6.55 1 Yes Yes 7 6 1 1
R:R:L362 R:R:N343 4.12 1 No Yes 3 7 2 1
R:R:V366 R:R:W367 3.68 1 Yes Yes 6 6 1 2
R:R:V366 R:R:Y370 8.83 1 Yes Yes 6 7 1 2
R:R:W367 R:R:Y370 12.54 1 Yes Yes 6 7 2 2
L:L:?1 R:R:L228 2.31 1 Yes No 0 4 0 1
R:R:S242 R:R:V241 1.62 0 No No 6 4 1 2
StatisticsValue
Average Number Of Links13.00
Average Number Of Links With An Hub7.00
Average Interaction Strength9.10
Average Nodes In Shell33.00
Average Hubs In Shell15.00
Average Links In Shell48.00
Average Links Mediated by Hubs In Shell41.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7SRQ A Amine 5-Hydroxytryptamine 5-HT2B Homo Sapiens LSD - - 2.7 2022-09-21 10.1016/j.neuron.2022.08.006

A 2D representation of the interactions of 7LD in 7SRQ
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:D135 15.85 1 Yes Yes 0 8 0 1
L:L:?1 R:R:V136 6.21 1 Yes No 0 7 0 1
L:L:?1 R:R:T140 3.69 1 Yes No 0 7 0 1
L:L:?1 R:R:A225 2.63 1 Yes No 0 7 0 1
L:L:?1 R:R:F340 21.33 1 Yes Yes 0 7 0 1
L:L:?1 R:R:N344 3.44 1 Yes No 0 6 0 1
L:L:?1 R:R:V366 11.18 1 Yes No 0 6 0 1
R:R:V107 R:R:W131 4.9 1 No Yes 7 6 2 2
R:R:D135 R:R:V107 5.84 1 Yes No 8 7 1 2
R:R:V107 R:R:Y370 3.79 1 No Yes 7 8 2 2
R:R:D135 R:R:W131 3.35 1 Yes Yes 8 6 1 2
R:R:D135 R:R:Y370 6.9 1 Yes Yes 8 8 1 2
R:R:A187 R:R:V136 3.39 6 No No 8 7 2 1
R:R:A225 R:R:T140 3.36 1 No No 7 7 1 1
R:R:M218 R:R:N344 7.01 0 No No 6 6 2 1
R:R:F341 R:R:S222 3.96 0 Yes No 7 7 2 2
R:R:N344 R:R:S222 4.47 0 No No 6 7 1 2
R:R:F340 R:R:F341 9.65 1 Yes Yes 7 7 1 2
R:R:F340 R:R:L362 3.65 1 Yes No 7 5 1 2
R:R:F340 R:R:V366 3.93 1 Yes No 7 6 1 1
R:R:V366 R:R:Y370 5.05 1 No Yes 6 8 1 2
L:L:?1 R:R:S139 2.5 1 Yes No 0 7 0 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub2.00
Average Interaction Strength8.35
Average Nodes In Shell17.00
Average Hubs In Shell6.00
Average Links In Shell22.00
Average Links Mediated by Hubs In Shell18.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7SRR A Amine 5-Hydroxytryptamine 5-HT2B Homo Sapiens LSD - chim(NtGi2L-Gs-CtGq)/Beta1/Gamma2 2.9 2022-09-21 10.1016/j.neuron.2022.08.006

A 2D representation of the interactions of 7LD in 7SRR
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:V107 R:R:W131 6.13 5 No Yes 7 6 2 1
R:R:D135 R:R:V107 2.92 5 Yes No 8 7 1 2
R:R:V107 R:R:Y370 3.79 5 No Yes 7 8 2 2
R:R:I110 R:R:W131 7.05 0 No Yes 5 6 2 1
R:R:W121 R:R:W131 4.69 13 Yes Yes 7 6 2 1
L:L:?1 R:R:W131 2.85 5 Yes Yes 0 6 0 1
R:R:D135 R:R:S139 4.42 5 Yes No 8 7 1 1
R:R:D135 R:R:Y370 10.34 5 Yes Yes 8 8 1 2
L:L:?1 R:R:D135 19.24 5 Yes Yes 0 8 0 1
R:R:A187 R:R:V136 3.39 0 No No 8 7 2 1
L:L:?1 R:R:V136 16.15 5 Yes No 0 7 0 1
R:R:S139 R:R:W337 2.47 5 No Yes 7 8 1 2
L:L:?1 R:R:S139 6.26 5 Yes No 0 7 0 1
R:R:A225 R:R:T140 3.36 0 No Yes 7 7 1 2
R:R:F217 R:R:V190 3.93 0 No No 7 6 1 2
R:R:F217 R:R:G221 3.01 0 No No 7 6 1 2
L:L:?1 R:R:F217 3.05 5 Yes No 0 7 0 1
R:R:M218 R:R:N344 7.01 0 No No 6 6 2 1
L:L:?1 R:R:A225 2.63 5 Yes No 0 7 0 1
R:R:F341 R:R:W337 8.02 5 Yes Yes 7 8 2 2
R:R:F340 R:R:F341 5.36 5 Yes Yes 7 7 1 2
R:R:F340 R:R:L362 4.87 5 Yes No 7 5 1 2
R:R:F340 R:R:V366 3.93 5 Yes No 7 6 1 1
L:L:?1 R:R:F340 16.26 5 Yes Yes 0 7 0 1
R:R:V366 R:R:Y370 6.31 5 No Yes 6 8 1 2
L:L:?1 R:R:V366 4.97 5 Yes No 0 6 0 1
L:L:?1 R:R:N344 2.29 5 Yes No 0 6 0 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub3.00
Average Interaction Strength8.19
Average Nodes In Shell22.00
Average Hubs In Shell9.00
Average Links In Shell27.00
Average Links Mediated by Hubs In Shell23.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7SRS A Amine 5-Hydroxytryptamine 5-HT2B Homo Sapiens LSD - Arrestin2 3.3 2022-09-21 10.1016/j.neuron.2022.08.006

A 2D representation of the interactions of 7LD in 7SRS
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:W131 1.9 2 Yes Yes 0 6 0 1
L:L:?1 R:R:D135 12.45 2 Yes No 0 8 0 1
L:L:?1 R:R:S139 3.76 2 Yes No 0 7 0 1
L:L:?1 R:R:A225 2.63 2 Yes No 0 7 0 1
L:L:?1 R:R:F340 11.18 2 Yes Yes 0 7 0 1
L:L:?1 R:R:F341 7.11 2 Yes Yes 0 7 0 1
L:L:?1 R:R:N344 2.29 2 Yes No 0 6 0 1
L:L:?1 R:R:V366 2.49 2 Yes Yes 0 6 0 1
R:R:V107 R:R:W131 3.68 2 No Yes 7 6 2 1
R:R:D135 R:R:V107 2.92 2 No No 8 7 1 2
R:R:V107 R:R:Y370 5.05 2 No Yes 7 8 2 2
R:R:I110 R:R:W131 12.92 0 No Yes 5 6 2 1
R:R:L132 R:R:W131 2.28 0 No Yes 5 6 2 1
R:R:D135 R:R:Y370 6.9 2 No Yes 8 8 1 2
R:R:A225 R:R:T140 3.36 0 No Yes 7 7 1 2
R:R:F341 R:R:S222 3.96 2 Yes No 7 7 1 2
R:R:N344 R:R:S222 4.47 2 No No 6 7 1 2
R:R:F226 R:R:W337 4.01 2 Yes Yes 8 8 2 2
R:R:F226 R:R:F341 17.15 2 Yes Yes 8 7 2 1
R:R:F341 R:R:W337 3.01 2 Yes Yes 7 8 1 2
R:R:F340 R:R:F341 7.5 2 Yes Yes 7 7 1 1
R:R:F340 R:R:N344 2.42 2 Yes No 7 6 1 1
R:R:F340 R:R:L362 8.53 2 Yes No 7 5 1 2
R:R:F340 R:R:F365 2.14 2 Yes No 7 5 1 2
R:R:F340 R:R:V366 2.62 2 Yes Yes 7 6 1 1
R:R:V366 R:R:W367 3.68 2 Yes Yes 6 7 1 2
R:R:V366 R:R:Y370 5.05 2 Yes Yes 6 8 1 2
R:R:W367 R:R:Y370 7.72 2 Yes Yes 7 8 2 2
L:L:?1 R:R:G221 1.43 2 Yes No 0 6 0 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub4.00
Average Interaction Strength5.03
Average Nodes In Shell21.00
Average Hubs In Shell10.00
Average Links In Shell29.00
Average Links Mediated by Hubs In Shell27.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7WC6 A Amine 5-Hydroxytryptamine 5-HT2A Homo Sapiens LSD - - 2.6 2022-01-26 10.1126/science.abl8615

A 2D representation of the interactions of 7LD in 7WC6
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:W151 15.2 1 Yes Yes 0 5 0 1
L:L:?1 R:R:D155 28.3 1 Yes Yes 0 8 0 1
L:L:?1 R:R:V156 14.91 1 Yes No 0 6 0 1
L:L:?1 R:R:S159 6.26 1 Yes No 0 7 0 1
L:L:?1 R:R:G238 4.28 1 Yes No 0 6 0 1
L:L:?1 R:R:F339 17.27 1 Yes Yes 0 7 0 1
L:L:?1 R:R:F340 11.18 1 Yes Yes 0 7 0 1
L:L:?1 R:R:N343 4.58 1 Yes No 0 7 0 1
L:L:?1 R:R:V366 9.94 1 Yes No 0 6 0 1
L:L:?1 R:R:Y370 3.91 1 Yes Yes 0 7 0 1
R:R:D155 R:R:V127 7.3 1 Yes No 8 8 1 2
R:R:V127 R:R:Y370 3.79 1 No Yes 8 7 2 1
R:R:M128 R:R:W367 5.82 1 Yes Yes 8 6 2 2
R:R:M128 R:R:Y370 10.78 1 Yes Yes 8 7 2 1
R:R:V130 R:R:W151 12.26 0 No Yes 4 5 2 1
R:R:S131 R:R:W367 7.41 1 No Yes 7 6 2 2
R:R:S131 R:R:Y370 5.09 1 No Yes 7 7 2 1
R:R:W141 R:R:W151 9.37 1 Yes Yes 7 5 2 1
R:R:C227 R:R:W141 13.06 1 No Yes 9 7 2 2
R:R:C227 R:R:W151 5.22 1 No Yes 9 5 2 1
R:R:D155 R:R:S159 4.42 1 Yes No 8 7 1 1
R:R:D155 R:R:Y370 4.6 1 Yes Yes 8 7 1 1
R:R:I210 R:R:V156 4.61 0 No No 6 6 2 1
R:R:S242 R:R:T160 9.59 0 No No 6 7 1 2
R:R:L229 R:R:V235 4.47 0 No No 4 6 2 1
R:R:F340 R:R:S239 3.96 1 Yes No 7 6 1 2
R:R:F243 R:R:F340 26.79 0 No Yes 8 7 2 1
R:R:F339 R:R:W336 6.01 1 Yes Yes 7 8 1 2
R:R:F340 R:R:W336 6.01 1 Yes Yes 7 8 1 2
R:R:W336 R:R:Y370 3.86 1 Yes Yes 8 7 2 1
R:R:F339 R:R:F340 9.65 1 Yes Yes 7 7 1 1
R:R:F339 R:R:N343 9.67 1 Yes No 7 7 1 1
R:R:F339 R:R:L362 4.87 1 Yes Yes 7 3 1 2
R:R:F339 R:R:V366 5.24 1 Yes No 7 6 1 1
R:R:L362 R:R:N343 5.49 1 Yes No 3 7 2 1
R:R:V366 R:R:Y370 8.83 1 No Yes 6 7 1 1
R:R:W367 R:R:Y370 18.33 1 Yes Yes 6 7 2 1
L:L:?1 R:R:S242 3.76 1 Yes No 0 6 0 1
L:L:?1 R:R:V235 3.73 1 Yes No 0 6 0 1
R:R:G238 R:R:I237 1.76 0 No No 6 4 1 2
R:R:V235 R:R:V347 1.6 0 No No 6 5 1 2
StatisticsValue
Average Number Of Links12.00
Average Number Of Links With An Hub5.00
Average Interaction Strength10.28
Average Nodes In Shell29.00
Average Hubs In Shell11.00
Average Links In Shell41.00
Average Links Mediated by Hubs In Shell36.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8FYT A Amine 5-Hydroxytryptamine 5-HT1A Homo Sapiens LSD - Gi1/Beta1/Gamma1 2.64 2024-05-15 10.1038/s41586-024-07403-2

A 2D representation of the interactions of 7LD in 8FYT
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:F112 3.81 1 Yes Yes 0 6 0 1
L:L:?1 R:R:I113 3.35 1 Yes No 0 7 0 1
L:L:?1 R:R:D116 30.77 1 Yes Yes 0 8 0 1
L:L:?1 R:R:V117 17.47 1 Yes No 0 8 0 1
L:L:?1 R:R:C120 4.96 1 Yes Yes 0 7 0 1
L:L:?1 R:R:T121 4.61 1 Yes Yes 0 8 0 1
L:L:?1 R:R:I189 8.93 1 Yes No 0 6 0 1
L:L:?1 R:R:S199 4.7 1 Yes No 0 8 0 1
L:L:?1 R:R:A203 4.93 1 Yes No 0 8 0 1
L:L:?1 R:R:W358 4.45 1 Yes Yes 0 8 0 1
L:L:?1 R:R:F361 20.95 1 Yes Yes 0 8 0 1
L:L:?1 R:R:F362 10.47 1 Yes Yes 0 7 0 1
L:L:?1 R:R:N386 8.59 1 Yes No 0 7 0 1
L:L:?1 R:R:Y390 10.08 1 Yes Yes 0 8 0 1
R:R:C120 R:R:V85 3.42 1 Yes No 7 8 1 2
R:R:F112 R:R:V89 5.24 1 Yes No 6 8 1 2
R:R:D116 R:R:V89 7.3 1 Yes No 8 8 1 2
R:R:V89 R:R:Y390 5.05 1 No Yes 8 8 2 1
R:R:L90 R:R:W387 3.42 1 Yes Yes 8 8 2 2
R:R:L90 R:R:Y390 4.69 1 Yes Yes 8 8 2 1
R:R:M92 R:R:W102 3.49 1 No Yes 6 9 2 2
R:R:F112 R:R:M92 11.2 1 Yes No 6 6 1 2
R:R:A93 R:R:Y390 4 0 No Yes 7 8 2 1
R:R:C109 R:R:W102 6.53 1 No Yes 9 9 2 2
R:R:F112 R:R:W102 10.02 1 Yes Yes 6 9 1 2
R:R:C187 R:R:W102 10.45 1 No Yes 9 9 2 2
R:R:C109 R:R:I113 3.27 1 No No 9 7 2 1
R:R:C109 R:R:C187 7.28 1 No No 9 9 2 2
R:R:C187 R:R:I113 3.27 1 No No 9 7 2 1
R:R:C120 R:R:D116 3.11 1 Yes Yes 7 8 1 1
R:R:D116 R:R:Y390 11.49 1 Yes Yes 8 8 1 1
R:R:I167 R:R:V117 3.07 0 Yes No 8 8 2 1
R:R:S168 R:R:V117 3.23 0 No No 8 8 2 1
R:R:C120 R:R:W358 5.22 1 Yes Yes 7 8 1 1
R:R:G164 R:R:T121 3.64 0 No Yes 8 8 2 1
R:R:I167 R:R:T121 6.08 0 Yes Yes 8 8 2 1
R:R:A203 R:R:T121 5.03 1 No Yes 8 8 1 1
R:R:F354 R:R:I124 5.02 1 Yes No 9 8 2 2
R:R:I124 R:R:W358 14.09 1 No Yes 8 8 2 1
R:R:S199 R:R:Y195 12.72 0 No Yes 8 8 1 2
R:R:S199 R:R:T200 3.2 0 No No 8 7 1 2
R:R:F362 R:R:T200 5.19 1 Yes No 7 7 1 2
R:R:F204 R:R:Y205 9.28 1 Yes Yes 8 7 2 2
R:R:F204 R:R:F354 8.57 1 Yes Yes 8 9 2 2
R:R:F204 R:R:W358 3.01 1 Yes Yes 8 8 2 1
R:R:F204 R:R:F362 20.36 1 Yes Yes 8 7 2 1
R:R:F362 R:R:Y205 3.09 1 Yes Yes 7 7 1 2
R:R:F354 R:R:W358 4.01 1 Yes Yes 9 8 2 1
R:R:F361 R:R:W358 3.01 1 Yes Yes 8 8 1 1
R:R:F362 R:R:W358 8.02 1 Yes Yes 7 8 1 1
R:R:G389 R:R:W358 8.44 0 No Yes 8 8 2 1
R:R:N392 R:R:W358 12.43 0 No Yes 9 8 2 1
R:R:F361 R:R:F362 12.86 1 Yes Yes 8 7 1 1
R:R:F361 R:R:I385 3.77 1 Yes Yes 8 6 1 2
R:R:F361 R:R:N386 7.25 1 Yes No 8 7 1 1
R:R:W387 R:R:Y390 19.29 1 Yes Yes 8 8 2 1
R:R:A365 R:R:F361 2.77 0 No Yes 8 8 2 1
StatisticsValue
Average Number Of Links14.00
Average Number Of Links With An Hub8.00
Average Interaction Strength9.86
Average Nodes In Shell37.00
Average Hubs In Shell18.00
Average Links In Shell57.00
Average Links Mediated by Hubs In Shell52.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8JXR A Amine Dopamine D1 Homo sapiens LSD - - 3.57 2024-09-04 doi.org/10.1016/j.neuron.2024.07.003

A 2D representation of the interactions of 7LD in 8JXR
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:W99 4.45 1 Yes Yes 0 5 0 1
L:L:?1 R:R:D103 15.91 1 Yes No 0 7 0 1
L:L:?1 R:R:I104 12.27 1 Yes No 0 6 0 1
L:L:?1 R:R:S107 9.39 1 Yes No 0 7 0 1
L:L:?1 R:R:S198 4.7 1 Yes No 0 7 0 1
L:L:?1 R:R:W285 6.23 1 Yes Yes 0 8 0 1
L:L:?1 R:R:F288 37.13 1 Yes Yes 0 7 0 1
L:L:?1 R:R:F289 8.57 1 Yes Yes 0 7 0 1
L:L:?1 R:R:F313 11.43 1 Yes Yes 0 4 0 1
L:L:?1 R:R:V317 13.98 1 Yes No 0 6 0 1
L:L:?1 R:R:W321 3.56 1 Yes Yes 0 7 0 1
R:R:D103 R:R:V77 5.84 1 No No 7 8 1 2
R:R:V77 R:R:W321 4.9 1 No Yes 8 7 2 1
R:R:M78 R:R:W318 5.82 1 No Yes 7 5 2 2
R:R:M78 R:R:W321 9.31 1 No Yes 7 7 2 1
R:R:F95 R:R:W80 5.01 1 Yes No 5 5 2 2
R:R:W80 R:R:W99 5.62 1 No Yes 5 5 2 1
R:R:K81 R:R:W99 5.8 1 Yes Yes 6 5 2 1
R:R:K81 R:R:W318 3.48 1 Yes Yes 6 5 2 2
R:R:K81 R:R:W321 4.64 1 Yes Yes 6 7 2 1
R:R:F95 R:R:W90 5.01 1 Yes Yes 5 8 2 2
R:R:W90 R:R:W99 7.5 1 Yes Yes 8 5 2 1
R:R:F95 R:R:W99 4.01 1 Yes Yes 5 5 2 1
R:R:V100 R:R:W99 3.68 0 No Yes 5 5 2 1
R:R:D103 R:R:W321 6.7 1 No Yes 7 7 1 1
R:R:I104 R:R:S155 6.19 0 No No 6 7 1 2
R:R:S107 R:R:W285 6.18 1 No Yes 7 8 1 1
R:R:I154 R:R:S198 4.64 0 No No 5 7 2 1
R:R:F289 R:R:S199 6.61 1 Yes No 7 7 1 2
R:R:F203 R:R:F281 4.29 0 Yes No 8 9 2 2
R:R:F203 R:R:F289 24.65 0 Yes Yes 8 7 2 1
R:R:F281 R:R:W285 10.02 1 No Yes 9 8 2 1
R:R:F281 R:R:N323 7.25 1 No Yes 9 9 2 2
R:R:F288 R:R:W285 6.01 1 Yes Yes 7 8 1 1
R:R:G320 R:R:W285 9.85 0 No Yes 7 8 2 1
R:R:N323 R:R:W285 9.04 1 Yes Yes 9 8 2 1
R:R:F288 R:R:F289 11.79 1 Yes Yes 7 7 1 1
R:R:F288 R:R:F313 6.43 1 Yes Yes 7 4 1 1
R:R:F313 R:R:L291 4.87 1 Yes No 4 5 1 2
R:R:F313 R:R:N292 4.83 1 Yes No 4 6 1 2
R:R:V317 R:R:W321 9.81 1 No Yes 6 7 1 1
R:R:W318 R:R:W321 14.06 1 Yes Yes 5 7 2 1
StatisticsValue
Average Number Of Links11.00
Average Number Of Links With An Hub6.00
Average Interaction Strength11.60
Average Nodes In Shell29.00
Average Hubs In Shell13.00
Average Links In Shell42.00
Average Links Mediated by Hubs In Shell39.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8ZSP A Amine Trace Amine Receptors TA1 Homo Sapiens LSD - chim(NtGi1L-Gs-CtGq)/Beta1/Gamma2 3.14 2024-07-24 10.1016/j.celrep.2024.114505

A 2D representation of the interactions of 7LD in 8ZSP
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L72 R:R:M77 4.24 0 No Yes 7 7 2 2
R:R:L72 R:R:S107 4.5 0 No Yes 7 6 2 1
R:R:H99 R:R:V76 4.15 1 Yes No 5 7 2 2
R:R:D103 R:R:V76 11.69 1 Yes No 6 7 1 2
R:R:V76 R:R:Y294 3.79 1 No Yes 7 7 2 1
R:R:M77 R:R:Y294 15.57 0 Yes Yes 7 7 2 1
R:R:R83 R:R:S80 7.91 1 No No 4 6 1 2
R:R:H99 R:R:S80 6.97 1 Yes No 5 6 2 2
R:R:S80 R:R:Y294 7.63 1 No Yes 6 7 2 1
R:R:H99 R:R:R83 4.51 1 Yes No 5 4 2 1
L:L:?1 R:R:R83 7.09 1 Yes No 0 4 0 1
L:L:?1 R:R:T100 3.69 1 Yes No 0 4 0 1
R:R:D103 R:R:S107 4.42 1 Yes Yes 6 6 1 1
R:R:D103 R:R:Y294 10.34 1 Yes Yes 6 7 1 1
L:L:?1 R:R:D103 15.85 1 Yes Yes 0 6 0 1
R:R:F154 R:R:I104 3.77 1 Yes Yes 4 4 2 1
R:R:I104 R:R:M158 4.37 1 Yes Yes 4 5 1 2
L:L:?1 R:R:I104 17.86 1 Yes Yes 0 4 0 1
R:R:S107 R:R:W264 4.94 1 Yes Yes 6 8 1 1
L:L:?1 R:R:S107 11.27 1 Yes Yes 0 6 0 1
R:R:P151 R:R:S108 3.56 0 Yes No 8 5 2 1
R:R:S108 R:R:S198 6.52 1 No No 5 6 1 1
L:L:?1 R:R:S108 5.01 1 Yes No 0 5 0 1
R:R:I111 R:R:W264 10.57 0 No Yes 8 8 2 1
R:R:F154 R:R:M158 7.46 1 Yes Yes 4 5 2 2
R:R:F154 R:R:T194 3.89 1 Yes No 4 5 2 1
R:R:F186 R:R:M158 3.73 1 Yes Yes 1 5 1 2
R:R:R179 R:R:S183 7.91 0 No No 2 4 2 1
L:L:?1 R:R:S183 3.76 1 Yes No 0 4 0 1
R:R:F186 R:R:V184 11.8 1 Yes No 1 4 1 1
L:L:?1 R:R:V184 8.7 1 Yes No 0 4 0 1
R:R:F186 R:R:S190 6.61 1 Yes No 1 6 1 2
R:R:F186 R:R:G191 4.52 1 Yes No 1 4 1 2
R:R:F186 R:R:T194 3.89 1 Yes No 1 5 1 1
L:L:?1 R:R:F186 6.1 1 Yes Yes 0 1 0 1
L:L:?1 R:R:T194 7.38 1 Yes No 0 5 0 1
R:R:F195 R:R:F199 6.43 1 Yes Yes 5 8 2 2
R:R:F195 R:R:F268 4.29 1 Yes Yes 5 7 2 1
R:R:F268 R:R:S198 3.96 1 Yes No 7 6 1 1
L:L:?1 R:R:S198 10.02 1 Yes No 0 6 0 1
R:R:F199 R:R:F268 22.51 1 Yes Yes 8 7 2 1
R:R:F267 R:R:W264 6.01 1 Yes Yes 5 8 1 1
R:R:F268 R:R:W264 12.03 1 Yes Yes 7 8 1 1
R:R:G293 R:R:W264 8.44 0 No Yes 7 8 2 1
R:R:N296 R:R:W264 10.17 1 Yes Yes 9 8 2 1
L:L:?1 R:R:W264 9.5 1 Yes Yes 0 8 0 1
R:R:F267 R:R:F268 9.65 1 Yes Yes 5 7 1 1
R:R:F267 R:R:T271 9.08 1 Yes No 5 5 1 2
R:R:F267 R:R:L289 4.87 1 Yes No 5 5 1 2
R:R:F267 R:R:I290 3.77 1 Yes No 5 5 1 1
L:L:?1 R:R:F267 14.22 1 Yes Yes 0 5 0 1
L:L:?1 R:R:F268 13.21 1 Yes Yes 0 7 0 1
L:L:?1 R:R:I290 11.91 1 Yes No 0 5 0 1
R:R:W291 R:R:Y294 13.5 0 Yes Yes 4 7 2 1
L:L:?1 R:R:Y294 3.91 1 Yes Yes 0 7 0 1
L:L:?1 R:R:N286 3.44 1 Yes No 0 4 0 1
R:R:A155 R:R:I104 3.25 0 No Yes 6 4 2 1
StatisticsValue
Average Number Of Links17.00
Average Number Of Links With An Hub8.00
Average Interaction Strength9.00
Average Nodes In Shell38.00
Average Hubs In Shell18.00
Average Links In Shell57.00
Average Links Mediated by Hubs In Shell54.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links12.27
Average Number Of Links With An Hub6.13
Average Interaction Strength8.72
Average Nodes In Shell30.33
Average Hubs In Shell13.67
Average Links In Shell43.93
Average Links Mediated by Hubs In Shell40.07

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

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Location of the nodes interacting with this ligand

(Click to enlarge 🔍)