Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:R42 5.8375419
2A:A:N50 9.114179
3A:A:K53 5.745499
4A:A:V214 7.645476
5A:A:F219 6.77571778
6A:A:H220 6.41417
7A:A:F222 8.792517
8A:A:Q227 6.574519
9A:A:K233 6.08333619
10A:A:W234 7.625619
11A:A:F238 9.898519
12A:A:Y253 8.47408
13A:A:R265 8.024179
14A:A:L270 5.8025406
15A:A:F273 5.55333629
16A:A:W277 11.2375426
17A:A:W281 9.80833615
18A:A:F290 5.91857799
19A:A:K293 8.0875409
20A:A:L297 3.864508
21A:A:F312 4.57428
22A:A:F315 11.408526
23A:A:Y318 7.194526
24A:A:P321 4.284525
25A:A:E330 8.564523
26A:A:Y339 7.808523
27A:A:F340 10.284527
28A:A:R342 8.046524
29A:A:E344 6.702525
30A:A:F345 8.9825408
31A:A:L346 5.0075424
32A:A:S349 4.1725427
33A:A:Y358 6.13754164
34A:A:C359 3.4925425
35A:A:Y360 10.28408
36A:A:F363 9.534525
37A:A:T364 7.7775499
38A:A:D368 10.32499
39A:A:N371 7.978599
40A:A:R373 6.59475
41A:A:R374 11.318594
42A:A:F376 7.12286778
43A:A:R385 9.166165
44A:A:L388 5.3175458
45A:A:L393 3.82167658
46A:A:L394 4.4375408
47B:B:L4 5.485404
48B:B:L7 3.47408
49B:B:L14 3.76408
50B:B:I37 4.19254102
51B:B:I43 3.7754103
52B:B:H54 9.46333669
53B:B:K57 9.378519
54B:B:W63 6.83333667
55B:B:L70 5.49465
56B:B:V71 4.565148
57B:B:Q75 8.216519
58B:B:L79 5.1075407
59B:B:I80 8.176568
60B:B:W82 10.2383669
61B:B:S84 4.4125465
62B:B:K89 5.25667669
63B:B:H91 6.10254145
64B:B:I93 6.72407
65B:B:L95 5.01408
66B:B:W99 9.862519
67B:B:M101 5.575419
68B:B:Y105 4.516676146
69B:B:N110 9.65414
70B:B:Y111 4.62333614
71B:B:V112 4.964148
72B:B:C114 4.37408
73B:B:L117 4.9775419
74B:B:C121 4.5325418
75B:B:I123 4.266516
76B:B:Y124 5.63667606
77B:B:E138 6.8825406
78B:B:H142 8.9925419
79B:B:Y145 6.93125818
80B:B:C149 3.815418
81B:B:F151 5.1825819
82B:B:Q156 7.48405
83B:B:I157 6.005417
84B:B:T159 5.87333619
85B:B:D163 10.2025419
86B:B:C166 4.2354118
87B:B:W169 8.79167618
88B:B:D170 6.81254189
89B:B:I171 4.515416
90B:B:Q176 5.9775414
91B:B:F180 9.3385117
92B:B:H183 9.695119
93B:B:D186 7.3125419
94B:B:V187 4.4265119
95B:B:F199 9.73754119
96B:B:S201 5.26254119
97B:B:C204 5.42833617
98B:B:D205 7.74754119
99B:B:K209 10.9454116
100B:B:W211 9.9325118
101B:B:R219 5.43435
102B:B:F222 8.524538
103B:B:H225 7.85143739
104B:B:D228 10.78419
105B:B:I229 5.545437
106B:B:I232 5.475438
107B:B:F235 7.15429786
108B:B:F241 7.21333636
109B:B:T243 7.7225438
110B:B:D246 6.305419
111B:B:D247 7.782539
112B:B:R251 8.74167638
113B:B:F253 7.505636
114B:B:D254 5.63409
115B:B:R256 9.095409
116B:B:D258 9.405437
117B:B:M262 4.6975484
118B:B:Y264 6.30167685
119B:B:H266 5.59484
120B:B:I273 6.63486
121B:B:F278 6.7425487
122B:B:R283 8.835109
123B:B:L284 5.084105
124B:B:L285 5.28486
125B:B:Y289 8.152587
126B:B:D290 5.684516
127B:B:C294 4.3885125
128B:B:V296 3.8354105
129B:B:K301 4.3725405
130B:B:H311 8.096129
131B:B:R314 14.592518
132B:B:W332 11.855619
133B:B:D333 6.3625129
134B:B:K337 10.854126
135B:B:W339 8.543336129
136G:G:I25 5.635432
137G:G:R27 7.768538
138G:G:Y40 13.3225486
139G:G:D48 7.626676109
140G:G:L51 4.746676106
141G:G:N59 3.6975409
142G:G:F61 5.54857768
143R:R:M30 6.885446
144R:R:I33 5.4447
145R:R:I34 4.5825446
146R:R:N41 6.115409
147R:R:V44 4.14219
148R:R:F51 5.548505
149R:R:H63 6.575406
150R:R:M65 6.3125459
151R:R:D69 7.3825409
152R:R:L72 5.0675407
153R:R:V76 5.13547
154R:R:M77 8.5875407
155R:R:M81 5.5425446
156R:R:W89 9.72833647
157R:R:F91 10.0333646
158R:R:F95 6.046545
159R:R:H99 7.652545
160R:R:H113 7.78667658
161R:R:S115 3.64407
162R:R:I117 4.96459
163R:R:S118 4.4275458
164R:R:P128 4.06578
165R:R:R130 6.295475
166R:R:Y131 7.004577
167R:R:W148 4.718559
168R:R:F160 5.55254224
169R:R:N164 10.384194
170R:R:R179 7.026676132
171R:R:F185 9.5885131
172R:R:F186 7.82754191
173R:R:S190 4.7685196
174R:R:F195 6.7725155
175R:R:F199 8.984158
176R:R:M206 7.3725459
177R:R:Y210 5.13333659
178R:R:Y214 6.035405
179R:R:Q220 7.044166
180R:R:L253 3.508557
181R:R:F260 5.162509
182R:R:W264 7.595717158
183R:R:F267 6.865155
184R:R:F268 9.79254157
185R:R:I281 6.36254132
186R:R:W291 7.14667644
187R:R:Y294 7.69833647
188R:R:L295 5.3275445
189R:R:T298 5.086547
190R:R:F299 4.405446
191R:R:N300 8.2175409
192R:R:Y304 6.47167659
193R:R:Y308 7.88408
194R:R:W310 7.4175406
195R:R:F311 7.0365219
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:L69 B:B:Y105 20.80264.69NoYes056
2B:B:D83 B:B:L69 21.66724.07NoNo085
3A:A:F222 A:A:R42 28.72246.41YesYes179
4A:A:D240 A:A:R42 28.69694.76NoYes169
5A:A:D240 B:B:K57 28.4945.53NoYes169
6B:B:K57 B:B:W332 56.163623.21YesYes199
7B:B:S316 B:B:W332 48.71964.94NoYes099
8B:B:C317 B:B:S316 48.29423.44NoNo079
9B:B:C317 B:B:M61 47.86914.86NoNo076
10B:B:M61 B:B:W63 47.44416.98NoYes067
11B:B:S84 B:B:W63 30.70784.94YesYes657
12B:B:S84 G:G:F61 29.93916.61YesYes658
13B:B:Y85 G:G:F61 23.04415.16NoYes648
14B:B:R68 B:B:Y85 22.930623.66NoNo054
15B:B:D83 B:B:R68 22.499417.87NoNo085
16A:A:R42 B:B:Q75 29.11918.18YesYes199
17B:B:K57 B:B:Q75 28.50226.78YesYes199
18A:A:F290 A:A:T364 99.42257.78YesYes999
19A:A:N292 A:A:T364 1007.31NoYes099
20A:A:K293 A:A:N292 99.96718.39YesNo099
21A:A:K293 A:A:L296 99.8068.46YesNo096
22A:A:L296 A:A:S251 99.88384.5NoNo069
23A:A:L297 A:A:S251 99.87823YesNo089
24A:A:L297 A:A:S250 96.96844.5YesNo086
25A:A:L291 A:A:S250 96.94664.5NoNo086
26A:A:L289 A:A:L291 97.53496.92NoNo098
27A:A:F345 A:A:L289 48.74348.53YesNo089
28A:A:F273 A:A:F345 48.97078.57YesYes098
29A:A:F246 A:A:F273 97.94324.29NoYes099
30A:A:D272 A:A:F246 97.86077.17NoNo089
31A:A:D272 A:A:R231 97.69567.15NoNo089
32A:A:R231 A:A:W234 97.61338NoYes099
33A:A:F238 A:A:W234 58.72594.01YesYes199
34A:A:F222 A:A:F238 29.45254.29YesYes179
35A:A:C359 A:A:L289 48.78883.17YesNo059
36A:A:C359 A:A:F273 49.03434.19YesYes259
37A:A:F238 B:B:W99 28.803414.03YesYes199
38A:A:R42 B:B:W99 29.28874YesYes199
39B:B:D290 B:B:G272 23.13151.68YesNo064
40B:B:D246 B:B:G272 23.32391.68YesNo094
41A:A:K233 B:B:D246 23.46235.53YesYes199
42A:A:K233 B:B:Y145 24.1593.58YesYes198
43A:A:F290 A:A:I288 48.40135.02YesNo099
44A:A:D378 A:A:I288 48.356112.59NoNo079
45A:A:D378 A:A:Y360 96.71514.94NoYes078
46A:A:D381 A:A:Y360 48.8910.34NoYes078
47A:A:F290 A:A:H362 48.35485.66YesNo999
48A:A:D378 A:A:H362 48.4278.82NoNo079
49A:A:Y358 A:A:Y360 47.6244.96YesYes048
50A:A:R385 A:A:Y358 47.37638.23YesYes1654
51A:A:D381 A:A:R385 47.362517.87NoYes1675
52A:A:L394 A:A:R385 94.77463.64YesYes085
53A:A:L388 A:A:L394 62.08958.3YesYes088
54A:A:L388 A:A:L393 60.44626.92YesYes588
55A:A:E392 R:R:Y308 31.49934.49NoYes078
56A:A:E392 R:R:K248 32.00976.75NoNo078
57A:A:L394 R:R:K248 32.35314.23YesNo088
58A:A:L393 R:R:L253 59.18294.15YesYes587
59G:G:D48 G:G:L50 10.32585.43YesNo099
60B:B:M45 G:G:L50 10.43145.65NoNo049
61B:B:L308 B:B:M45 10.53714.24NoNo074
62B:B:C294 B:B:L308 10.49126.35YesNo057
63B:B:C294 B:B:L318 11.00563.17YesNo056
64B:B:L318 B:B:S277 11.10573NoNo065
65B:B:G162 B:B:Y145 14.340810.14NoYes198
66B:B:G162 B:B:S161 14.24963.71NoNo199
67B:B:H142 B:B:S161 13.523913.95YesNo199
68B:B:L318 B:B:S275 21.53946.01NoNo068
69B:B:S275 B:B:T274 21.64263.2NoNo088
70R:R:L253 R:R:Y210 57.98773.52YesYes579
71R:R:M206 R:R:Y210 29.77735.99YesYes599
72R:R:F260 R:R:M206 29.62068.71YesYes099
73R:R:F260 R:R:W264 26.86824.01YesYes098
74R:R:F267 R:R:W264 10.0248.02YesYes1558
75R:R:V259 R:R:V303 27.16324.81NoNo068
76R:R:F299 R:R:V259 26.62213.93YesNo066
77R:R:F299 R:R:L295 11.10227.31YesYes465
78R:R:I33 R:R:L295 10.00497.14YesYes475
79R:R:I33 R:R:W291 17.81447.05YesYes474
80R:R:Y210 R:R:Y304 17.12483.97YesYes599
81R:R:V303 R:R:Y304 18.52887.57NoYes089
82R:R:R121 R:R:Y308 24.37811.32NoYes098
83R:R:R121 R:R:Y304 17.33488.23NoYes599
84R:R:F299 R:R:T298 14.44143.89YesYes467
85R:R:I33 R:R:T298 10.01194.56YesYes477
86R:R:S107 R:R:W264 15.85974.94NoYes068
87R:R:L72 R:R:S107 15.67633YesNo076
88R:R:L72 R:R:V76 15.6984.47YesYes077
89R:R:H99 R:R:V76 15.22636.92YesYes457
90R:R:M65 R:R:Y304 12.97885.99YesYes599
91R:R:H113 R:R:M65 15.66017.88YesYes589
92R:R:F95 R:R:I98 11.2263.77YesNo054
93R:R:F160 R:R:I98 10.4535.02YesNo044
94B:B:L70 B:B:W63 13.397810.25YesYes657
95B:B:L70 B:B:W82 11.73984.56YesYes659
96B:B:V112 B:B:Y105 10.83633.79YesYes1486
97B:B:V112 B:B:Y124 10.40593.79YesYes086
98A:A:W234 B:B:Y145 37.896.75YesYes198
99B:B:D290 B:B:T274 21.50014.34YesNo168
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8ZSJ
Class A
SubFamily Amine
Type Trace Amine Receptors
SubType TA1
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1L-Gs-CtGq)/Beta1/Gamma2
PDB Resolution 2.8
Date 2024-07-24
D.O.I. 10.1016/j.celrep.2024.114505
Net Summary
Imin 3
Number of Linked Nodes 863
Number of Links 1098
Number of Hubs 195
Number of Links mediated by Hubs 710
Number of Communities 22
Number of Nodes involved in Communities 288
Number of Links involved in Communities 433
Path Summary
Number Of Nodes in MetaPath 100
Number Of Links MetaPath 99
Number of Shortest Paths 5105346
Length Of Smallest Path 3
Average Path Length 42.7328
Length of Longest Path 76
Minimum Path Strength 1.495
Average Path Strength 6.76263
Maximum Path Strength 25.785
Minimum Path Correlation 0.7
Average Path Correlation 0.99314
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2
Average % Of Corr. Nodes 30.8735
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 53.5891
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • cation binding   • metal ion binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • D1 dopamine receptor binding   • dopamine receptor binding   • G protein activity   • molecular function regulator activity   • enzyme regulator activity   • molecular function activator activity   • phosphorus-oxygen lyase activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • adenylate cyclase activator activity   • adenylate cyclase activity   • regulation of biological process   • cell population proliferation   • regulation of cellular process   • positive regulation of cell population proliferation   • biological regulation   • positive regulation of biological process   • positive regulation of neural precursor cell proliferation   • regulation of cell population proliferation   • cellular process   • neural precursor cell proliferation   • positive regulation of cellular process   • regulation of neural precursor cell proliferation   • reactive oxygen species metabolic process   • regulation of superoxide metabolic process
Gene OntologyBiological Process• regulation of biological process   • cell population proliferation   • regulation of cellular process   • positive regulation of cell population proliferation   • biological regulation   • positive regulation of biological process   • positive regulation of neural precursor cell proliferation   • regulation of cell population proliferation   • cellular process   • neural precursor cell proliferation   • positive regulation of cellular process   • regulation of neural precursor cell proliferation   • reactive oxygen species metabolic process   • regulation of superoxide metabolic process   • positive regulation of reactive oxygen species metabolic process   • superoxide metabolic process   • positive regulation of metabolic process   • superoxide anion generation   • metabolic process   • positive regulation of superoxide anion generation   • regulation of superoxide anion generation   • regulation of metabolic process   • regulation of reactive oxygen species metabolic process   • regulation of calcium ion transport   • regulation of localization   • transport   • regulation of transport   • regulation of monoatomic ion transport   • establishment of localization   • metal ion transport   • calcium ion transport   • localization   • monoatomic ion transport   • regulation of metal ion transport   • monoatomic cation transport   • cellular response to stimulus   • positive regulation of cell communication   • positive regulation of signal transduction   • response to stimulus   • signaling   • regulation of signal transduction   • intracellular signal transduction   • cell communication   • positive regulation of response to stimulus   • positive regulation of ERK1 and ERK2 cascade   • regulation of intracellular signal transduction   • intracellular signaling cassette   • signal transduction   • regulation of signaling   • positive regulation of MAPK cascade   • positive regulation of intracellular signal transduction   • regulation of MAPK cascade   • regulation of response to stimulus   • MAPK cascade   • regulation of cell communication   • ERK1 and ERK2 cascade   • regulation of ERK1 and ERK2 cascade   • positive regulation of signaling   • negative regulation of signaling   • negative regulation of biological process   • negative regulation of G protein-coupled receptor signaling pathway   • negative regulation of cell communication   • negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • negative regulation of cellular process   • regulation of G protein-coupled receptor signaling pathway   • adenylate cyclase-activating adrenergic receptor signaling pathway   • negative regulation of response to stimulus   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • negative regulation of signal transduction   • negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell division   • regulation of body fluid levels   • multicellular organismal process   • renal system process   • system process   • positive regulation of urine volume   • regulation of urine volume   • regulation of biological quality   • regulation of vascular associated smooth muscle cell proliferation   • positive regulation of vascular associated smooth muscle cell proliferation   • regulation of smooth muscle cell proliferation   • smooth muscle cell proliferation   • positive regulation of smooth muscle cell proliferation   • muscle cell proliferation   • vascular associated smooth muscle cell proliferation   • cell-cell signaling   • gamma-aminobutyric acid signaling pathway   • purinergic nucleotide receptor signaling pathway   • cell surface receptor signaling pathway   • G protein-coupled purinergic receptor signaling pathway   • G protein-coupled adenosine receptor signaling pathway   • regulation of molecular function   • negative regulation of lyase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • negative regulation of molecular function   • negative regulation of catalytic activity   • negative regulation of adenylate cyclase activity   • regulated exocytosis   • regulation of calcium ion-dependent exocytosis   • negative regulation of transport   • negative regulation of regulated secretory pathway   • vesicle-mediated transport   • regulation of regulated secretory pathway   • secretion by cell   • regulation of secretion by cell   • negative regulation of secretion   • negative regulation of exocytosis   • negative regulation of secretion by cell   • calcium-ion regulated exocytosis   • secretion   • negative regulation of calcium ion-dependent exocytosis   • export from cell   • regulation of vesicle-mediated transport   • regulation of secretion   • exocytosis   • regulation of exocytosis   • regulation of programmed cell death   • negative regulation of apoptotic signaling pathway   • negative regulation of programmed cell death   • regulation of apoptotic process   • cell death   • apoptotic signaling pathway   • negative regulation of apoptotic process   • apoptotic process   • programmed cell death   • regulation of apoptotic signaling pathway   • cellular response to nitrogen compound   • response to peptide hormone   • insulin receptor signaling pathway   • regulation of cellular response to insulin stimulus   • cell surface receptor protein tyrosine kinase signaling pathway   • cellular response to endogenous stimulus   • response to hormone   • enzyme-linked receptor protein signaling pathway   • cellular response to hormone stimulus   • positive regulation of cellular response to insulin stimulus   • response to endogenous stimulus   • regulation of insulin receptor signaling pathway   • positive regulation of insulin receptor signaling pathway   • response to oxygen-containing compound   • cellular response to peptide hormone stimulus   • response to nitrogen compound   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • response to chemical   • response to insulin   • cellular response to insulin stimulus   • positive regulation of locomotion   • regulation of cell motility   • positive regulation of cell migration   • regulation of locomotion   • positive regulation of cell motility   • regulation of cell migration   • cell migration   • cell motility   • locomotion   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • trans-synaptic signaling   • modulation of chemical synaptic transmission   • negative regulation of synaptic transmission   • chemical synaptic transmission   • synaptic signaling   • regulation of trans-synaptic signaling   • anterograde trans-synaptic signaling   • cellular response to acetylcholine   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • response to nutrient levels   • response to nutrient   • developmental process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • response to glucagon   • cellular response to glucagon stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • response to wounding   • platelet activation   • cognition   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • homeostatic process   • adaptive thermogenesis   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • protein localization   • establishment of protein localization   • nitrogen compound transport   • cellular macromolecule localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • protein secretion   • regulation of protein secretion   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • amide transport   • signal release   • regulation of peptide transport   • regulation of establishment of protein localization   • regulation of protein transport   • peptide transport   • protein transport   • regulation of cellular localization   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • insulin secretion   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • midbody   • cellular anatomical structure   • membrane   • membrane-bounded organelle   • intracellular anatomical structure   • dense core granule   • intracellular vesicle   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • cytoplasmic vesicle   • organelle   • secretory granule   • secretory vesicle
Gene OntologyCellular Component• midbody   • cellular anatomical structure   • membrane   • membrane-bounded organelle   • intracellular anatomical structure   • dense core granule   • intracellular vesicle   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • cytoplasmic vesicle   • organelle   • secretory granule   • secretory vesicle   • cytoplasm   • vesicle   • neuronal dense core vesicle   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • membraneless organelle   • intracellular membraneless organelle   • microtubule cytoskeleton   • cytosol   • somatodendritic compartment   • cell projection   • dendrite   • dendritic tree   • neuron projection   • plasma membrane bounded cell projection   • nucleus   • membrane-enclosed lumen   • intracellular organelle lumen   • nucleoplasm   • organelle lumen   • nuclear lumen   • neuron to neuron synapse   • synapse   • cell junction   • hippocampal mossy fiber to CA3 synapse   • cell body   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • trans-Golgi network   • organelle membrane   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • G-protein beta-subunit binding   • fibroblast proliferation   • tetrapyrrole binding   • heme binding   • electron transfer activity   • cation binding   • transition metal ion binding   • iron ion binding   • ion binding   • metal ion binding   • small molecule binding   • G protein-coupled amine receptor activity   • molecular transducer activity   • trace-amine receptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • electron transport chain   • metabolic process   • generation of precursor metabolites and energy   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • periplasmic space   • endoplasmic reticulum subcompartment   • nuclear outer membrane-endoplasmic reticulum membrane network   • endoplasmic reticulum   • endoplasmic reticulum membrane
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8ZSJ_Chain_A
VSAEDKAAA ERSKMIDKN LREDGEKAA AATHRLLLL GADNSGKST 
IVKQMRSGI FETKFQVDK VNFHMFDVG AQRDERRKW IQCFNDVTA 
IIFVVDSSD YNRLQEALN DFKSIWNNR WLRTISVIL FLNKQDLLA 
EKVLAGKSK IEDYFPEFA RYTTPEDAT PEPGEDPRV TRAKYFIRD 
EFLRISTAS GDGRHYCYP HFTCSVDTE NARRIFNDC RDIIQRMHL 
RQYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8ZSJ_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8ZSJ_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ96RJ0
Sequence
>8ZSJ_Chain_R
VRASLYSLM VLIILTTLV GNLIVIVSI SHFKQLHTP TNWLIHSMA 
TVDFLLGCL VMPYSMVRS AEHCWYFGE VFCKIHTST DIMLSSASI 
FHLSFISID RYYAVCDPL RYKAKMNIL VICVMIFIS WSVPAVFAF 
GMIFLELNF KGAEEIYYK HVHCRGGCS VFFSKISGV LTFMTSFYI 
PGSIMLCVY YRIYLIAKE QARLISDAN QKERKAVKT LGIVMGVFL 
ICWCPFFIC TVMDPFLHY IIPPTLNDV LIWFGYLNS TFNPMVYAF 
FYPWFRKAL KMM


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9JKQAAmineTrace Amine ReceptorsTA1Homo sapiensMETH-Gs/β1/γ22.662024-10-16doi.org/10.1021/acs.jmedchem.4c01961
8ZSVAAmineTrace Amine ReceptorsTA1Mus musculusRO5263397-chim(NtGi1-Gs)/β1/γ22.962024-07-2410.1016/j.celrep.2024.114505
8ZSSAAmineTrace Amine ReceptorsTA1Homo sapiensRO5263397-chim(NtGi1-Gs)/β1/γ23.072024-07-2410.1016/j.celrep.2024.114505
8ZSPAAmineTrace Amine ReceptorsTA1Homo sapiensLSD-chim(NtGi1L-Gs-CtGq)/β1/γ23.142024-07-2410.1016/j.celrep.2024.114505
8ZSJAAmineTrace Amine ReceptorsTA1Homo sapiens--chim(NtGi1L-Gs-CtGq)/β1/γ22.82024-07-2410.1016/j.celrep.2024.114505
8UHBAAmineTrace Amine ReceptorsTA1Homo sapiensRO5256390-Gs/β1/γ23.352024-01-1010.1038/s41467-023-44601-4
8WCCAAmineTrace Amine ReceptorsTA1Mus musculusCyclohexylammonium Ion--3.042023-12-2710.1016/j.cell.2023.10.014
8WCBAAmineTrace Amine ReceptorsTA1Mus musculusCyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ23.12023-12-2710.1016/j.cell.2023.10.014
8WC9AAmineTrace Amine ReceptorsTA1Mus musculusZH8651-chim(NtGi1-Gs-CtGq)/β1/γ23.22023-12-2710.1016/j.cell.2023.10.014
8WCAAAmineTrace Amine ReceptorsTA1Homo sapiens2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ23.482023-12-2710.1016/j.cell.2023.10.014
8WC8AAmineTrace Amine ReceptorsTA1Homo sapiensZH8651-chim(NtGi1-Gs)/β1/γ22.92023-12-2710.1016/j.cell.2023.10.014
8WC7AAmineTrace Amine ReceptorsTA1Mus musculusZH8667-chim(NtGi1-Gs)/β1/γ23.12023-12-2710.1016/j.cell.2023.10.014
8WC6AAmineTrace Amine ReceptorsTA1Mus musculus2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ23.22023-12-2710.1016/j.cell.2023.10.014
8WC5AAmineTrace Amine ReceptorsTA1Mus musculusTetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ23.32023-12-2710.1016/j.cell.2023.10.014
8WC4AAmineTrace Amine ReceptorsTA1Mus musculusZH8651-chim(NtGi1-Gs)/β1/γ23.12023-12-2710.1016/j.cell.2023.10.014
8WC3AAmineTrace Amine ReceptorsTA1Mus musculusSEP-363856-chim(NtGi1-Gs)/β1/γ232023-12-2710.1016/j.cell.2023.10.014
8W8AAAmineTrace Amine ReceptorsTA1Homo sapiensRO5256390-chim(NtGi1L-Gs)/β1/γ22.82023-11-2210.1038/s41586-023-06775-1
8W89AAmineTrace Amine ReceptorsTA1Homo sapiensPEA-chim(NtGi1L-Gs)/β1/γ232023-11-2210.1038/s41586-023-06775-1
8W87AAmineTrace Amine ReceptorsTA1Homo sapiensMETH-chim(NtGi1L-Gs)/β1/γ22.82023-11-2210.1038/s41586-023-06775-1
8W88AAmineTrace Amine ReceptorsTA1Homo sapiensSEP-363856-Gs/β1/γ22.62023-11-2210.1038/s41586-023-06775-1
8JSOAAmineTrace Amine ReceptorsTA1Homo sapiensAMPH-chim(NtGi1-Gs)/β1/γ23.42023-11-1510.1038/s41586-023-06804-z
8JLRAAmineTrace Amine ReceptorsTA1Homo sapiensA77636-chim(NtGi1-Gs)/β1/γ232023-11-1510.1038/s41586-023-06804-z
8JLKAAmineTrace Amine ReceptorsTA1Mus musculusUlotaront-chim(NtGi1-Gs)/β1/γ23.222023-11-1510.1038/s41586-023-06804-z
8JLJAAmineTrace Amine ReceptorsTA1Mus musculusT1AM-chim(NtGi1-Gs)/β1/γ23.12023-11-1510.1038/s41586-023-06804-z
8JLQAAmineTrace Amine ReceptorsTA1Homo sapiensFenoldopam-Gs/β1/γ22.842023-11-1510.1038/s41586-023-06804-z
8JLPAAmineTrace Amine ReceptorsTA1Homo sapiensRalmitaront-Gs/β1/γ23.232023-11-1510.1038/s41586-023-06804-z
8JLOAAmineTrace Amine ReceptorsTA1Homo sapiensUlotaront-Gs/β1/γ23.522023-11-1510.1038/s41586-023-06804-z
8JLNAAmineTrace Amine ReceptorsTA1Homo sapiensT1AM-Gs/β1/γ23.242023-11-1510.1038/s41586-023-06804-z




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