Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:?1 9.15222910
2R:R:Q22 5.91433
3R:R:I47 2.8225408
4R:R:H62 4.89406
5R:R:V67 4.435408
6R:R:M76 6.17407
7R:R:R82 7.87465
8R:R:W88 10.5075467
9R:R:H112 8.895408
10R:R:Y130 5.1775427
11R:R:I139 4.2275407
12R:R:L164 6.1725473
13R:R:F184 6.2075472
14R:R:F185 4.725412
15R:R:F198 7.064517
16R:R:V208 4.195406
17R:R:Y209 5.174509
18R:R:F257 6.6825409
19R:R:W261 5.85857717
20R:R:F264 8.945616
21R:R:F265 8.99616
22R:R:V269 4.17405
23R:R:I278 7.8875481
24R:R:N297 6.2025459
25R:R:Y301 5.155459
26R:R:Y305 7.192508
27R:R:F308 2.828508
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:?1 R:R:D102 38.660518.79YesNo106
2R:R:D102 R:R:I75 38.26535.6NoNo066
3R:R:H98 R:R:I75 35.92879.28NoNo056
4R:R:H98 R:R:R82 33.60264.51NoYes055
5R:R:R82 R:R:W88 22.76578YesYes657
6R:R:G180 R:R:W88 17.64891.41NoYes037
7R:R:G179 R:R:G180 16.32122.11NoNo053
8R:R:C87 R:R:G179 13.64491.96NoNo045
9R:R:C87 R:R:Y89 12.29638.06NoNo041
10R:R:E85 R:R:Y89 10.93742.24NoNo041
11L:L:?1 R:R:W261 38.37973.38YesYes107
12R:R:F198 R:R:W261 48.51284.01YesYes177
13R:R:F198 R:R:F257 1006.43YesYes079
14R:R:F257 R:R:M205 99.909911.2YesNo098
15R:R:M205 R:R:S117 99.67076.13NoNo088
16R:R:S117 R:R:Y209 98.31175.09NoYes089
17R:R:M253 R:R:Y209 69.64925.99NoYes089
18R:R:M253 R:R:V300 50.53393.04NoNo088
19R:R:V300 R:R:Y301 49.89957.57NoYes089
20R:R:N297 R:R:Y301 47.48673.49YesYes599
21R:R:N297 R:R:P298 31.59193.26YesNo099
22R:R:N40 R:R:P298 30.67676.52NoNo099
23R:R:D68 R:R:N40 13.842512.12NoNo099
24L:L:?1 R:R:F265 41.46854.82YesYes106
25R:R:F198 R:R:F265 52.374713.93YesYes176
26R:R:R120 R:R:Y209 25.11615.14NoYes099
27R:R:R120 R:R:Y305 24.377710.29NoYes098
28R:R:W307 R:R:Y305 47.282116.4NoYes068
29R:R:F308 R:R:W307 29.66444.01YesNo086
30R:R:M253 R:R:Y305 30.01114.79NoYes088
31R:R:F69 R:R:N40 16.92093.62NoNo079
32R:R:F69 R:R:I44 11.97052.51NoNo077
33R:R:H62 R:R:I44 10.91669.28YesNo067
34R:R:F308 R:R:I47 14.94832.51YesYes088
35R:R:N58 R:R:W307 16.80656.78NoNo096
36R:R:N58 R:R:T57 13.20464.39NoNo298
37R:R:M64 R:R:N297 19.15349.82NoYes099
38R:R:H112 R:R:M64 18.148110.51YesNo089
39R:R:H112 R:R:S63 10.91668.37YesNo089
40R:R:D119 R:R:T57 11.32225.78NoNo298
41L:L:?1 R:R:F185 33.30443.61YesYes102
42R:R:F185 R:R:S189 29.73386.61YesNo126
43R:R:S186 R:R:S189 28.62446.52NoNo066
44R:R:S186 R:R:V167 21.2823.23NoNo063
45R:R:F184 R:R:V167 20.04096.55YesNo023
46R:R:F184 R:R:L164 10.38274.87YesYes723
47R:R:F265 R:R:S197 10.39316.61YesNo065
48R:R:F264 R:R:L286 16.13747.31YesNo065
49R:R:L282 R:R:L286 13.51666.92NoNo045
50R:R:I278 R:R:L282 10.84035.71YesNo814
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:D102 18.79 1 Yes No 0 6 0 1
L:L:?1 R:R:I103 16.94 1 Yes No 0 4 0 1
L:L:?1 R:R:S106 8.91 1 Yes No 0 6 0 1
L:L:?1 R:R:F185 3.61 1 Yes Yes 0 2 0 1
L:L:?1 R:R:W261 3.38 1 Yes Yes 0 7 0 1
L:L:?1 R:R:F264 10.84 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F265 4.82 1 Yes Yes 0 6 0 1
L:L:?1 R:R:Y287 6.96 1 Yes No 0 5 0 1
L:L:?1 R:R:Y291 8.12 1 Yes No 0 7 0 1
R:R:D102 R:R:I75 5.6 1 No No 6 6 1 2
R:R:D102 R:R:Y291 11.49 1 No No 6 7 1 1
R:R:I103 R:R:Y153 3.63 0 No No 4 4 1 2
R:R:A154 R:R:I103 3.25 0 No No 7 4 2 1
R:R:S106 R:R:W261 3.71 1 No Yes 6 7 1 1
R:R:P183 R:R:Y287 6.95 0 No No 4 5 2 1
R:R:F185 R:R:S189 6.61 1 Yes No 2 6 1 2
R:R:F185 R:R:G190 4.52 1 Yes No 2 5 1 2
R:R:A193 R:R:F185 4.16 0 No Yes 4 2 2 1
R:R:G190 R:R:S189 3.71 1 No No 5 6 2 2
R:R:F194 R:R:F198 5.36 1 No Yes 5 7 2 2
R:R:F194 R:R:F265 8.57 1 No Yes 5 6 2 1
R:R:F265 R:R:S197 6.61 1 Yes No 6 5 1 2
R:R:F198 R:R:W261 4.01 1 Yes Yes 7 7 2 1
R:R:F198 R:R:F265 13.93 1 Yes Yes 7 6 2 1
R:R:F264 R:R:W261 6.01 1 Yes Yes 6 7 1 1
R:R:F265 R:R:W261 5.01 1 Yes Yes 6 7 1 1
R:R:G290 R:R:W261 9.85 0 No Yes 6 7 2 1
R:R:N293 R:R:W261 9.04 0 No Yes 9 7 2 1
R:R:F264 R:R:F265 15 1 Yes Yes 6 6 1 1
R:R:F264 R:R:T268 10.38 1 Yes No 6 4 1 2
R:R:F264 R:R:L286 7.31 1 Yes No 6 5 1 2
R:R:F264 R:R:Y287 4.13 1 Yes No 6 5 1 1
R:R:W288 R:R:Y291 13.5 0 No No 5 7 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8JLK_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.04
Number of Linked Nodes 244
Number of Links 259
Number of Hubs 27
Number of Links mediated by Hubs 108
Number of Communities 8
Number of Nodes involved in Communities 37
Number of Links involved in Communities 46
Path Summary
Number Of Nodes in MetaPath 51
Number Of Links MetaPath 50
Number of Shortest Paths 43469
Length Of Smallest Path 3
Average Path Length 15.2867
Length of Longest Path 33
Minimum Path Strength 1.435
Average Path Strength 6.56711
Maximum Path Strength 17.865
Minimum Path Correlation 0.7
Average Path Correlation 0.9202
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.57143
Average % Of Corr. Nodes 39.8692
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 40.3165
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • tetrapyrrole binding   • heme binding   • electron transfer activity   • cation binding   • transition metal ion binding   • iron ion binding   • ion binding   • metal ion binding   • small molecule binding   • G protein-coupled amine receptor activity   • molecular transducer activity   • trace-amine receptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • electron transport chain   • metabolic process   • cellular process   • generation of precursor metabolites and energy   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway
Gene OntologyBiological Process• electron transport chain   • metabolic process   • cellular process   • generation of precursor metabolites and energy   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • phospholipase C-activating G protein-coupled receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to oxygen-containing compound   • response to nitrogen compound   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • cellular anatomical structure   • periplasmic space   • membrane   • cell periphery   • plasma membrane   • membrane-bounded organelle   • intracellular anatomical structure   • organelle subcompartment   • intracellular membrane-bounded organelle   • endomembrane system   • endoplasmic reticulum subcompartment   • intracellular organelle   • organelle   • nuclear outer membrane-endoplasmic reticulum membrane network
Gene OntologyCellular Component• cellular anatomical structure   • periplasmic space   • membrane   • cell periphery   • plasma membrane   • membrane-bounded organelle   • intracellular anatomical structure   • organelle subcompartment   • intracellular membrane-bounded organelle   • endomembrane system   • endoplasmic reticulum subcompartment   • intracellular organelle   • organelle   • nuclear outer membrane-endoplasmic reticulum membrane network   • endoplasmic reticulum   • cytoplasm   • organelle membrane   • endoplasmic reticulum membrane   • protein binding   • binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • synapse   • cell junction   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • G-protein beta/gamma-subunit complex binding   • G protein activity   • molecular function regulator activity   • enzyme regulator activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • molecular function activator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • cation binding   • metal ion binding   • D2 dopamine receptor binding   • adenylate cyclase inhibitor activity   • molecular function inhibitor activity   • cyclase inhibitor activity   • enzyme inhibitor activity   • magnesium ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • sensory perception of smell   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to glucagon   • cellular response to glucagon stimulus   • skeletal system development   • bone development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of multicellular organismal process   • regulation of metabolic process   • positive regulation of cellular process   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • localization   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • intracellular protein localization   • regulation of peptide hormone secretion   • regulation of signaling   • regulation of transport   • secretion   • regulation of hormone levels   • regulation of peptide transport   • regulation of establishment of protein localization   • establishment of protein localization to extracellular region   • export from cell   • regulation of protein transport   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • cellular localization   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • cell division   • leukocyte migration   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • negative regulation of protein transport   • negative regulation of transport   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • negative regulation of peptide hormone secretion   • negative regulation of establishment of protein localization   • negative regulation of protein secretion   • negative regulation of signaling   • negative regulation of cell communication   • negative regulation of peptide secretion   • negative regulation of cellular process   • negative regulation of protein localization   • negative regulation of insulin secretion   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of protein localization to cell cortex   • positive regulation of protein localization   • protein localization to cell cortex   • cellular response to forskolin   • response to forskolin   • Golgi apparatus subcompartment   • Golgi apparatus   • trans-Golgi network membrane   • trans-Golgi network   • midbody   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell cortex   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • nucleoplasm   • ciliary basal body
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeUJL
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeUJL
NameSEP-363856
SynonymsUlotaront; SEP-363856; SEP-856
Identifier
FormulaC9 H13 N O S
Molecular Weight183.271
SMILES
PubChem89532783
Formal Charge0
Total Atoms25
Total Chiral Atoms1
Total Bonds26
Total Aromatic Bonds5

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ923Y8
Sequence
>8JLK_nogp_Chain_R
REVQASLYS LMSLIILAT LVGNLIVII SISHFKQLH TPTNWLLHS 
MAIVDFLLG CLIMPCSMV RTVERCWYF GEILCKVHT STDIMLSSA 
SIFHLAFIS IDRYCAVCD PLRYKAKIN ISTILVMIL VSWSLPAVY 
AFGMIFLEL NLKGVEELY RSQVSDLGG CSPFFSKVS GVLAFMTSF 
YIPGSVMLF VYYRIYFIA KGQARSAKT LGIMVGVFL VCWCPFFLC 
TVLDPFLGY VIPPSLNDA LYWFGYLNS ALNPMVYAF FYPWFRR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8WC3AAmineTrace Amine ReceptorsTA1Mus musculusSEP-363856-chim(NtGi1-Gs)/β1/γ232023-12-27doi.org/10.1016/j.cell.2023.10.014
8WC3 (No Gprot) AAmineTrace Amine ReceptorsTA1Mus musculusSEP-363856-32023-12-27doi.org/10.1016/j.cell.2023.10.014
8WC4AAmineTrace Amine ReceptorsTA1Mus musculusZH8651-chim(NtGi1-Gs)/β1/γ23.12023-12-27doi.org/10.1016/j.cell.2023.10.014
8WC4 (No Gprot) AAmineTrace Amine ReceptorsTA1Mus musculusZH8651-3.12023-12-27doi.org/10.1016/j.cell.2023.10.014
8WC5AAmineTrace Amine ReceptorsTA1Mus musculusTetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ23.32023-12-27doi.org/10.1016/j.cell.2023.10.014
8WC5 (No Gprot) AAmineTrace Amine ReceptorsTA1Mus musculusTetramethylammonium Ion-3.32023-12-27doi.org/10.1016/j.cell.2023.10.014
8WC6AAmineTrace Amine ReceptorsTA1Mus musculus2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ23.22023-12-27doi.org/10.1016/j.cell.2023.10.014
8WC6 (No Gprot) AAmineTrace Amine ReceptorsTA1Mus musculus2-Phenylethylamine-3.22023-12-27doi.org/10.1016/j.cell.2023.10.014
8WC7AAmineTrace Amine ReceptorsTA1Mus musculusZH8667-chim(NtGi1-Gs)/β1/γ23.12023-12-27doi.org/10.1016/j.cell.2023.10.014
8WC7 (No Gprot) AAmineTrace Amine ReceptorsTA1Mus musculusZH8667-3.12023-12-27doi.org/10.1016/j.cell.2023.10.014
8WC8AAmineTrace Amine ReceptorsTA1Homo sapiensZH8651-chim(NtGi1-Gs)/β1/γ22.92023-12-27doi.org/10.1016/j.cell.2023.10.014
8WC8 (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensZH8651-2.92023-12-27doi.org/10.1016/j.cell.2023.10.014
8WC9AAmineTrace Amine ReceptorsTA1Mus musculusZH8651-chim(NtGi1-Gs-CtGq)/β1/γ23.22023-12-27doi.org/10.1016/j.cell.2023.10.014
8WC9 (No Gprot) AAmineTrace Amine ReceptorsTA1Mus musculusZH8651-3.22023-12-27doi.org/10.1016/j.cell.2023.10.014
8WCAAAmineTrace Amine ReceptorsTA1Homo sapiens2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ23.482023-12-27doi.org/10.1016/j.cell.2023.10.014
8WCA (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiens2-Phenylethylamine-3.482023-12-27doi.org/10.1016/j.cell.2023.10.014
8WCBAAmineTrace Amine ReceptorsTA1Mus musculusCyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ23.12023-12-27doi.org/10.1016/j.cell.2023.10.014
8WCB (No Gprot) AAmineTrace Amine ReceptorsTA1Mus musculusCyclohexylammonium Ion-3.12023-12-27doi.org/10.1016/j.cell.2023.10.014
8WCCAAmineTrace Amine ReceptorsTA1Mus musculusCyclohexylammonium Ion--3.042023-12-27doi.org/10.1016/j.cell.2023.10.014
8ZSJAAmineTrace Amine ReceptorsTA1Homo sapiens--chim(NtGi1L-Gs-CtGq)/β1/γ22.82024-07-24doi.org/10.1016/j.celrep.2024.114505
8ZSJ (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiens--2.82024-07-24doi.org/10.1016/j.celrep.2024.114505
8ZSPAAmineTrace Amine ReceptorsTA1Homo sapiensLSD-chim(NtGi1L-Gs-CtGq)/β1/γ23.142024-07-24doi.org/10.1016/j.celrep.2024.114505
8ZSP (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensLSD-3.142024-07-24doi.org/10.1016/j.celrep.2024.114505
8ZSSAAmineTrace Amine ReceptorsTA1Homo sapiensRO5263397-chim(NtGi1-Gs)/β1/γ23.072024-07-24doi.org/10.1016/j.celrep.2024.114505
8ZSS (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensRO5263397-3.072024-07-24doi.org/10.1016/j.celrep.2024.114505
8ZSVAAmineTrace Amine ReceptorsTA1Mus musculusRO5263397-chim(NtGi1-Gs)/β1/γ22.962024-07-24doi.org/10.1016/j.celrep.2024.114505
8ZSV (No Gprot) AAmineTrace Amine ReceptorsTA1Mus musculusRO5263397-2.962024-07-24doi.org/10.1016/j.celrep.2024.114505
8UHBAAmineTrace Amine ReceptorsTA1Homo sapiensRO5256390-Gs/β1/γ23.352024-01-10doi.org/10.1038/s41467-023-44601-4
8UHB (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensRO5256390-3.352024-01-10doi.org/10.1038/s41467-023-44601-4
8W87AAmineTrace Amine ReceptorsTA1Homo sapiensMETH-chim(NtGi1L-Gs)/β1/γ22.82023-11-22doi.org/10.1038/s41586-023-06775-1
8W87 (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensMETH-2.82023-11-22doi.org/10.1038/s41586-023-06775-1
8W88AAmineTrace Amine ReceptorsTA1Homo sapiensSEP-363856-Gs/β1/γ22.62023-11-22doi.org/10.1038/s41586-023-06775-1
8W88 (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensSEP-363856-2.62023-11-22doi.org/10.1038/s41586-023-06775-1
8W89AAmineTrace Amine ReceptorsTA1Homo sapiensPEA-chim(NtGi1L-Gs)/β1/γ232023-11-22doi.org/10.1038/s41586-023-06775-1
8W89 (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensPEA-32023-11-22doi.org/10.1038/s41586-023-06775-1
8W8AAAmineTrace Amine ReceptorsTA1Homo sapiensRO5256390-chim(NtGi1L-Gs)/β1/γ22.82023-11-22doi.org/10.1038/s41586-023-06775-1
8W8A (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensRO5256390-2.82023-11-22doi.org/10.1038/s41586-023-06775-1
8JLJAAmineTrace Amine ReceptorsTA1Mus musculusT1AM-chim(NtGi1-Gs)/β1/γ23.12023-11-15doi.org/10.1038/s41586-023-06804-z
8JLJ (No Gprot) AAmineTrace Amine ReceptorsTA1Mus musculusT1AM-3.12023-11-15doi.org/10.1038/s41586-023-06804-z
8JLKAAmineTrace Amine ReceptorsTA1Mus musculusUlotaront-chim(NtGi1-Gs)/β1/γ23.222023-11-15doi.org/10.1038/s41586-023-06804-z
8JLK (No Gprot) AAmineTrace Amine ReceptorsTA1Mus musculusUlotaront-3.222023-11-15doi.org/10.1038/s41586-023-06804-z
8JLNAAmineTrace Amine ReceptorsTA1Homo sapiensT1AM-Gs/β1/γ23.242023-11-15doi.org/10.1038/s41586-023-06804-z
8JLN (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensT1AM-3.242023-11-15doi.org/10.1038/s41586-023-06804-z
8JLOAAmineTrace Amine ReceptorsTA1Homo sapiensUlotaront-Gs/β1/γ23.522023-11-15doi.org/10.1038/s41586-023-06804-z
8JLO (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensUlotaront-3.522023-11-15doi.org/10.1038/s41586-023-06804-z
8JLPAAmineTrace Amine ReceptorsTA1Homo sapiensRalmitaront-Gs/β1/γ23.232023-11-15doi.org/10.1038/s41586-023-06804-z
8JLP (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensRalmitaront-3.232023-11-15doi.org/10.1038/s41586-023-06804-z
8JLQAAmineTrace Amine ReceptorsTA1Homo sapiensFenoldopam-Gs/β1/γ22.842023-11-15doi.org/10.1038/s41586-023-06804-z
8JLQ (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensFenoldopam-2.842023-11-15doi.org/10.1038/s41586-023-06804-z
8JLRAAmineTrace Amine ReceptorsTA1Homo sapiensA77636-chim(NtGi1-Gs)/β1/γ232023-11-15doi.org/10.1038/s41586-023-06804-z
8JLR (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensA77636-32023-11-15doi.org/10.1038/s41586-023-06804-z
8JSOAAmineTrace Amine ReceptorsTA1Homo sapiensAMPH-chim(NtGi1-Gs)/β1/γ23.42023-11-15doi.org/10.1038/s41586-023-06804-z
8JSO (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensAMPH-3.42023-11-15doi.org/10.1038/s41586-023-06804-z
9JKQAAmineTrace Amine ReceptorsTA1Homo sapiensMETH-Gs/β1/γ22.662024-10-16doi.org/10.1021/acs.jmedchem.4c01961
9JKQ (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensMETH-2.662024-10-16doi.org/10.1021/acs.jmedchem.4c01961




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