psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:R83	9.08	Yes	No	0	0	4
2	L:L:?1	R:R:T100	6.01	Yes	No	0	0	4
3	L:L:?1	R:R:D103	15.68	Yes	No	0	0	6
4	L:L:?1	R:R:I104	7.76	Yes	No	0	0	4
5	L:L:?1	R:R:S107	10.21	Yes	No	0	0	6
6	L:L:?1	R:R:V184	9.11	Yes	No	1	0	4
7	L:L:?1	R:R:F186	6.62	Yes	Yes	1	0	1
8	L:L:?1	R:R:F267	16.56	Yes	Yes	1	0	5
9	L:L:?1	R:R:I290	12.61	Yes	Yes	1	0	5
10	R:R:H87	R:R:R23	9.03	No	No	0	4	4
11	R:R:V31	R:R:Y27	7.57	No	No	0	5	6
12	R:R:M30	R:R:M81	8.66	No	No	4	6	6
13	R:R:M30	R:R:W291	20.94	No	Yes	4	6	4
14	R:R:M81	R:R:V31	4.56	No	No	0	6	5
15	R:R:I33	R:R:W291	4.7	No	Yes	0	7	4
16	R:R:I34	R:R:M77	8.75	No	Yes	0	6	7
17	R:R:M77	R:R:T37	6.02	Yes	No	0	7	7
18	R:R:T298	R:R:T37	4.71	No	No	0	7	7
19	R:R:F70	R:R:L38	6.09	Yes	No	0	7	6
20	R:R:D69	R:R:N41	6.73	Yes	No	0	9	9
21	R:R:F70	R:R:N41	4.83	Yes	No	0	7	9
22	R:R:N41	R:R:P301	9.77	No	No	0	9	9
23	R:R:F311	R:R:V44	6.55	Yes	No	0	9	9
24	R:R:H63	R:R:I45	7.95	Yes	No	5	6	8
25	R:R:I45	R:R:T67	4.56	No	No	5	8	6
26	R:R:F311	R:R:S47	7.93	Yes	No	0	9	8
27	R:R:I48	R:R:N59	7.08	No	Yes	0	7	9
28	R:R:H63	R:R:I48	6.63	Yes	No	0	6	7
29	R:R:F51	R:R:H50	7.92	No	No	0	5	5
30	R:R:F51	R:R:L54	6.09	No	Yes	0	5	8
31	R:R:F51	R:R:M318	6.22	No	No	0	5	6
32	R:R:H55	R:R:K52	11.79	No	No	0	8	6
33	R:R:L54	R:R:Q53	5.32	Yes	No	0	8	5
34	R:R:L54	R:R:N59	5.49	Yes	Yes	0	8	9
35	R:R:A314	R:R:L54	4.73	No	Yes	0	7	8
36	R:R:H55	R:R:W60	6.35	No	No	0	8	4
37	R:R:N59	R:R:T56	11.7	Yes	No	0	9	8
38	R:R:I140	R:R:P57	5.08	No	No	0	7	6
39	R:R:D120	R:R:T58	7.23	No	No	0	9	8
40	R:R:R121	R:R:T58	5.17	Yes	No	0	9	8
41	R:R:N59	R:R:W310	10.17	Yes	Yes	0	9	6
42	R:R:H63	R:R:W60	6.35	Yes	No	0	6	4
43	R:R:I117	R:R:L61	4.28	No	No	0	9	7
44	R:R:I140	R:R:L61	8.56	No	No	0	7	7
45	R:R:L61	R:R:M143	4.24	No	No	0	7	6
46	R:R:H63	R:R:T67	5.48	Yes	No	5	6	6
47	R:R:H113	R:R:S64	5.58	Yes	No	0	8	9
48	R:R:I144	R:R:S64	10.84	No	No	0	7	9
49	R:R:D69	R:R:M65	4.16	Yes	Yes	2	9	9
50	R:R:H113	R:R:M65	5.25	Yes	Yes	2	8	9
51	R:R:M65	R:R:N300	8.41	Yes	Yes	2	9	9
52	R:R:M65	R:R:Y304	5.99	Yes	Yes	0	9	9
53	R:R:H113	R:R:V68	5.54	Yes	No	2	8	8
54	R:R:V68	R:R:W148	8.58	No	No	2	8	9
55	R:R:D69	R:R:S110	8.83	Yes	No	2	9	9
56	R:R:D69	R:R:S297	7.36	Yes	No	0	9	9
57	R:R:D69	R:R:N300	8.08	Yes	Yes	2	9	9
58	R:R:L72	R:R:V76	4.47	Yes	Yes	0	7	7
59	R:R:L72	R:R:M77	4.24	Yes	Yes	0	7	7
60	R:R:L106	R:R:L72	5.54	No	Yes	0	6	7
61	R:R:L72	R:R:S297	7.51	Yes	No	0	7	9
62	R:R:H99	R:R:V76	4.15	Yes	Yes	0	5	7
63	R:R:T102	R:R:V76	4.76	No	Yes	0	4	7
64	R:R:D103	R:R:V76	11.69	No	Yes	0	6	7
65	R:R:M77	R:R:Y294	14.37	Yes	Yes	0	7	7
66	R:R:F91	R:R:Y79	9.28	Yes	Yes	3	6	5
67	R:R:F95	R:R:Y79	17.54	No	Yes	3	5	5
68	R:R:H99	R:R:Y79	7.62	Yes	Yes	0	5	5
69	R:R:R83	R:R:S80	9.22	No	No	0	4	6
70	R:R:H99	R:R:S80	5.58	Yes	No	0	5	6
71	R:R:S80	R:R:Y294	7.63	No	Yes	0	6	7
72	R:R:M81	R:R:W291	4.65	No	Yes	4	6	4
73	R:R:E86	R:R:V82	7.13	No	No	0	4	5
74	R:R:F91	R:R:V82	7.87	Yes	No	0	6	5
75	R:R:R83	R:R:W89	6	No	Yes	0	4	7
76	R:R:D287	R:R:S84	8.83	No	No	4	3	5
77	R:R:S84	R:R:W291	6.18	No	Yes	4	5	4
78	R:R:C88	R:R:Y90	5.38	No	No	0	4	1
79	R:R:F91	R:R:W89	16.04	Yes	Yes	3	6	7
80	R:R:F95	R:R:W89	6.01	No	Yes	3	5	7
81	R:R:C96	R:R:W89	6.53	No	Yes	3	9	7
82	R:R:H99	R:R:W89	6.35	Yes	Yes	0	5	7
83	R:R:C182	R:R:W89	14.37	No	Yes	3	9	7
84	R:R:F91	R:R:F95	7.5	Yes	No	3	6	5
85	R:R:E93	R:R:K97	6.75	No	No	0	2	6
86	R:R:C182	R:R:C96	7.28	No	No	3	9	9
87	R:R:I159	R:R:K97	4.36	No	No	0	6	6
88	R:R:F160	R:R:K97	6.2	Yes	No	0	4	6
89	R:R:F160	R:R:I98	5.02	Yes	No	0	4	4
90	R:R:F156	R:R:S101	9.25	No	No	0	4	6
91	R:R:I159	R:R:S101	7.74	No	No	0	6	6
92	R:R:D103	R:R:Y294	10.34	No	Yes	0	6	7
93	R:R:L106	R:R:M105	4.24	No	No	0	6	5
94	R:R:F156	R:R:M105	4.98	No	No	0	4	5
95	R:R:S107	R:R:W264	4.94	No	Yes	0	6	8
96	R:R:S108	R:R:S198	6.52	No	No	0	5	6
97	R:R:N300	R:R:S110	4.47	Yes	No	2	9	9
98	R:R:I111	R:R:W264	11.74	No	Yes	0	8	8
99	R:R:F112	R:R:P151	10.11	No	No	0	6	8
100	R:R:H113	R:R:S147	13.95	Yes	No	0	8	7
101	R:R:H113	R:R:W148	4.23	Yes	No	2	8	9
102	R:R:L114	R:R:M206	4.24	No	No	0	9	9
103	R:R:L114	R:R:N300	9.61	No	Yes	0	9	9
104	R:R:L114	R:R:Y304	9.38	No	Yes	0	9	9
105	R:R:I205	R:R:S115	4.64	No	No	0	6	7
106	R:R:F116	R:R:M143	19.9	No	No	0	7	6
107	R:R:F116	R:R:I146	6.28	No	No	0	7	3
108	R:R:F116	R:R:S147	6.61	No	No	0	7	7
109	R:R:I117	R:R:R121	5.01	No	Yes	0	9	9
110	R:R:I117	R:R:Y304	6.04	No	Yes	0	9	9
111	R:R:M206	R:R:S118	6.13	No	No	0	9	8
112	R:R:S118	R:R:V209	6.46	No	No	0	8	7
113	R:R:S118	R:R:Y210	6.36	No	Yes	0	8	9
114	R:R:D120	R:R:Y131	11.49	No	Yes	6	9	7
115	R:R:D120	R:R:M135	8.32	No	Yes	6	9	7
116	R:R:R121	R:R:Y210	7.2	Yes	Yes	0	9	9
117	R:R:R121	R:R:Y308	11.32	Yes	Yes	0	9	8
118	R:R:C126	R:R:Y122	17.47	No	Yes	0	6	8
119	R:R:V209	R:R:Y122	7.57	No	Yes	0	7	8
120	R:R:R212	R:R:Y122	16.46	No	Yes	0	5	8
121	R:R:M135	R:R:Y123	7.18	Yes	No	0	7	4
122	R:R:A124	R:R:Y131	8.01	No	Yes	0	8	7
123	R:R:I213	R:R:V125	4.61	No	No	0	9	8
124	R:R:I216	R:R:V125	4.61	No	No	0	5	8
125	R:R:C126	R:R:D127	6.22	No	No	0	6	5
126	R:R:D127	R:R:K134	4.15	No	No	0	5	4
127	R:R:K134	R:R:R130	6.19	No	No	0	4	5
128	R:R:M135	R:R:Y131	4.79	Yes	Yes	6	7	7
129	R:R:N136	R:R:V139	5.91	No	No	0	8	5
130	R:R:F145	R:R:S149	7.93	No	No	0	5	4
131	R:R:F154	R:R:V150	9.18	No	Yes	0	4	4
132	R:R:F156	R:R:F160	6.43	No	Yes	0	4	4
133	R:R:G157	R:R:L161	6.84	No	No	0	6	4
134	R:R:N164	R:R:V184	4.43	No	No	1	4	4
135	R:R:F186	R:R:N164	7.25	Yes	No	1	1	4
136	R:R:E169	R:R:F165	4.66	No	Yes	0	4	4
137	R:R:F165	R:R:Y172	12.38	Yes	Yes	1	4	3
138	R:R:F165	R:R:F185	5.36	Yes	Yes	1	4	1
139	R:R:E169	R:R:G167	4.91	No	No	0	4	4
140	R:R:A168	R:R:I171	4.87	No	No	0	3	2
141	R:R:I171	R:R:K174	5.82	No	No	0	2	4
142	R:R:F185	R:R:I171	6.28	Yes	No	0	1	2
143	R:R:F185	R:R:Y172	8.25	Yes	Yes	1	1	3
144	R:R:H175	R:R:S183	8.37	No	No	0	3	4
145	R:R:F185	R:R:H175	14.71	Yes	No	0	1	3
146	R:R:P283	R:R:R179	7.21	No	No	0	1	2
147	R:R:F186	R:R:V184	13.11	Yes	No	1	1	4
148	R:R:F185	R:R:Y279	12.38	Yes	No	0	1	1
149	R:R:I189	R:R:S187	4.64	No	No	0	4	4
150	R:R:F276	R:R:K188	9.93	No	No	0	5	3
151	R:R:F195	R:R:F199	7.5	Yes	Yes	1	5	8
152	R:R:F195	R:R:Y200	7.22	Yes	No	0	5	5
153	R:R:F195	R:R:F268	5.36	Yes	Yes	1	5	7
154	R:R:F195	R:R:V272	10.49	Yes	No	0	5	6
155	R:R:M196	R:R:Y200	5.99	No	No	0	5	5
156	R:R:F199	R:R:F260	7.5	Yes	No	0	8	9
157	R:R:C265	R:R:F199	5.59	No	Yes	0	6	8
158	R:R:F199	R:R:F268	20.36	Yes	Yes	1	8	7
159	R:R:I201	R:R:P202	5.08	No	No	0	6	9
160	R:R:F260	R:R:M206	6.22	No	No	0	9	9
161	R:R:C208	R:R:R212	4.18	No	No	0	4	5
162	R:R:M257	R:R:Y210	4.79	No	Yes	0	8	9
163	R:R:L215	R:R:Y211	15.24	No	No	0	4	3
164	R:R:K218	R:R:Y214	7.17	No	Yes	0	6	5
165	R:R:V250	R:R:Y214	6.31	No	Yes	0	8	5
166	R:R:E219	R:R:I216	5.47	No	No	0	3	5
167	R:R:E219	R:R:Q220	12.74	No	No	0	3	6
168	R:R:L223	R:R:R222	4.86	No	No	0	4	4
169	R:R:I255	R:R:K251	5.82	No	No	0	6	6
170	R:R:F307	R:R:T252	6.49	No	No	0	7	9
171	R:R:V259	R:R:V303	4.81	No	No	0	6	8
172	R:R:C263	R:R:N296	7.87	No	No	0	8	9
173	R:R:F267	R:R:W264	7.02	Yes	Yes	1	5	8
174	R:R:F268	R:R:W264	8.02	Yes	Yes	1	7	8
175	R:R:G293	R:R:W264	8.44	No	Yes	0	7	8
176	R:R:N296	R:R:W264	9.04	No	Yes	0	9	8
177	R:R:F267	R:R:F268	5.36	Yes	Yes	1	5	7
178	R:R:F267	R:R:T271	7.78	Yes	No	0	5	5
179	R:R:F267	R:R:L289	6.09	Yes	No	0	5	5
180	R:R:F267	R:R:I290	5.02	Yes	Yes	1	5	5
181	R:R:D274	R:R:I281	15.39	No	No	0	2	2
182	R:R:P275	R:R:Y279	5.56	No	No	0	4	1
183	R:R:I281	R:R:L285	4.28	No	No	0	2	4
184	R:R:L285	R:R:P282	6.57	No	No	0	4	1
185	R:R:D287	R:R:W291	7.82	No	Yes	4	3	4
186	R:R:I290	R:R:Y294	6.04	Yes	Yes	0	5	7
187	R:R:W291	R:R:Y294	11.58	Yes	Yes	0	4	7
188	R:R:F299	R:R:L295	12.18	No	No	0	6	5
189	R:R:N296	R:R:N300	8.17	No	Yes	0	9	9
190	R:R:V303	R:R:Y304	8.83	No	Yes	0	8	9
191	R:R:A305	R:R:F311	8.32	No	Yes	0	7	9
192	R:R:F306	R:R:F311	7.5	Yes	Yes	0	6	9
193	R:R:W310	R:R:Y308	12.54	Yes	Yes	0	6	8
194	R:R:P309	R:R:R312	4.32	No	No	0	5	8
195	R:R:F311	R:R:W310	11.02	Yes	Yes	0	9	6
196	R:R:G40	R:R:P301	4.06	No	No	0	9	9
197	R:R:F299	R:R:V259	3.93	No	No	0	6	6
198	R:R:V176	R:R:Y172	3.79	No	Yes	0	3	3
199	R:R:V256	R:R:Y210	3.79	No	Yes	0	8	9
200	R:R:F306	R:R:I43	3.77	Yes	No	0	6	7
201	R:R:F195	R:R:I269	3.77	Yes	No	0	5	6
202	R:R:F306	R:R:M302	3.73	Yes	No	0	6	6
203	R:R:F307	R:R:K251	3.72	No	No	0	7	6
204	R:R:L26	R:R:R23	3.64	No	No	0	5	4
205	R:R:I213	R:R:Y122	3.63	No	Yes	0	9	8
206	R:R:F165	R:R:N164	3.62	Yes	No	1	4	4
207	R:R:D226	R:R:R222	3.57	No	No	0	4	4
208	R:R:P151	R:R:S108	3.56	No	No	0	8	5
209	R:R:P202	R:R:S115	3.56	No	No	0	9	7
210	R:R:P151	R:R:V150	3.53	No	Yes	0	8	4
211	R:R:I137	R:R:W60	3.52	No	No	0	2	4
212	R:R:L253	R:R:Y210	3.52	No	Yes	0	7	9
213	R:R:G73	R:R:M77	3.49	No	Yes	0	7	7
214	R:R:A66	R:R:V44	3.39	No	No	0	9	9
215	R:R:A109	R:R:V68	3.39	No	No	0	7	8
216	R:R:I111	R:R:P202	3.39	No	No	0	8	9
217	R:R:E86	R:R:Y90	3.37	No	No	0	4	1
218	R:R:K188	R:R:P275	3.35	No	No	0	3	4
219	R:R:C141	R:R:I137	3.27	No	No	0	1	2
220	R:R:H177	R:R:Y173	3.27	No	No	0	4	2
221	R:R:C270	R:R:I281	3.27	No	No	0	4	2
222	R:R:S187	R:R:S190	3.26	No	No	0	4	6
223	R:R:A155	R:R:I104	3.25	No	No	0	6	4
224	R:R:A152	R:R:M105	3.22	No	No	0	3	5
225	R:R:S198	R:R:T194	3.2	No	No	0	6	5
226	R:R:C265	R:R:L261	3.17	No	No	0	6	6
227	R:R:C270	R:R:L289	3.17	No	No	0	4	5
228	R:R:T298	R:R:T36	3.14	No	No	0	7	5
229	R:R:F307	R:R:Y308	3.09	No	Yes	0	7	8
230	R:R:I146	R:R:V142	3.07	No	No	0	3	3
231	R:R:I146	R:R:V150	3.07	No	Yes	0	3	4
232	R:R:M158	R:R:S190	3.07	No	No	0	5	6
233	R:R:M196	R:R:V192	3.04	No	No	0	5	5
234	R:R:F260	R:R:G203	3.01	No	No	0	9	6
235	R:R:L35	R:R:V31	2.98	No	No	0	5	5
236	R:R:L42	R:R:V46	2.98	No	No	0	4	4
237	R:R:L32	R:R:T36	2.95	No	No	0	5	5
238	R:R:I119	R:R:I205	2.94	No	No	0	6	6
239	R:R:L207	R:R:M257	2.83	No	No	0	5	8
240	R:R:I224	R:R:N228	2.83	No	No	0	5	4
241	R:R:I290	R:R:N286	2.83	Yes	No	0	5	4
242	R:R:G92	R:R:W89	2.81	No	Yes	0	8	7
243	R:R:C74	R:R:F70	2.79	No	Yes	0	4	7
244	R:R:P78	R:R:Y79	2.78	No	Yes	0	8	5
245	R:R:P309	R:R:Y308	2.78	No	Yes	0	5	8
246	R:R:L71	R:R:L75	2.77	No	No	0	7	5
247	R:R:L138	R:R:N136	2.75	No	No	0	4	8
248	R:R:E170	R:R:K174	2.7	No	No	0	3	4
249	R:R:L231	R:R:Q232	2.66	No	No	0	3	5
250	R:R:F186	R:R:S190	2.64	Yes	No	0	1	6
251	R:R:F292	R:R:V288	2.62	No	No	0	7	4
252	R:R:S204	R:R:Y200	2.54	No	No	0	4	5
253	R:R:F70	R:R:L42	2.44	Yes	No	0	7	4
254	R:R:F292	R:R:L295	2.44	No	No	0	7	5
255	R:R:F306	R:R:L315	2.44	Yes	No	0	6	7
256	R:R:I62	R:R:W310	2.35	No	Yes	0	8	6
257	R:R:L253	R:R:Y214	2.34	No	Yes	0	7	5
258	R:R:L71	R:R:W148	2.28	No	No	0	7	9
259	R:R:G180	R:R:G181	2.11	No	No	0	4	3
260	R:R:Y172	R:R:Y173	1.99	Yes	No	0	3	2
261	R:R:C182	R:R:G181	1.96	No	No	0	9	3
262	R:R:P282	R:R:P283	1.95	No	No	0	1	1
263	R:R:C265	R:R:P266	1.88	No	No	0	6	9
264	R:R:G40	R:R:V39	1.84	No	No	0	9	5
265	R:R:G191	R:R:V272	1.84	No	No	0	4	6
266	R:R:A217	R:R:A249	1.79	No	No	0	8	8
267	R:R:P282	R:R:T284	1.75	No	No	0	1	3
268	R:R:G254	R:R:L253	1.71	No	No	0	5	7
269	R:R:C263	R:R:I262	1.64	No	No	0	8	6
270	R:R:S149	R:R:V150	1.62	No	Yes	0	4	4
271	R:R:D127	R:R:P128	1.61	No	No	0	5	8
272	R:R:I45	R:R:S49	1.55	No	No	0	8	3
273	R:R:A227	R:R:D226	1.54	No	No	0	4	4
274	R:R:M135	R:R:V139	1.52	Yes	No	0	7	5
275	R:R:M143	R:R:V139	1.52	No	No	0	6	5
276	R:R:M273	R:R:V272	1.52	No	No	0	4	6
277	R:R:A85	R:R:E86	1.51	No	No	0	5	4
278	R:R:L193	R:R:T197	1.47	No	No	0	3	4
279	R:R:I33	R:R:L29	1.43	No	No	0	7	5
280	R:R:E93	R:R:V94	1.43	No	No	0	2	1
281	R:R:L26	R:R:M30	1.41	No	No	0	5	6
282	R:R:L277	R:R:M273	1.41	No	No	0	3	4
283	R:R:L161	R:R:L163	1.38	No	No	0	4	6
284	R:R:H278	R:R:I280	1.33	No	No	0	1	1
285	R:R:R23	R:R:V22	1.31	No	No	0	4	3
286	R:R:F112	R:R:T197	1.3	No	No	0	6	4
287	R:R:F160	R:R:L161	1.22	Yes	No	0	4	4
288	R:R:L129	R:R:R130	1.21	No	No	0	7	5
289	R:R:K132	R:R:Y131	1.19	No	Yes	0	4	7
290	R:R:L215	R:R:Y214	1.17	No	Yes	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	10.4044	9	1	0
2	R:R:L54	5.4075	4	0	8
3	R:R:N59	8.61	4	0	9
4	R:R:H63	6.6025	4	5	6
5	R:R:M65	5.9525	4	2	9
6	R:R:D69	7.032	5	2	9
7	R:R:F70	4.0375	4	0	7
8	R:R:L72	5.44	4	0	7
9	R:R:V76	6.2675	4	0	7
10	R:R:M77	7.374	5	0	7
11	R:R:Y79	9.305	4	3	5
12	R:R:W89	8.30143	7	3	7
13	R:R:F91	10.1725	4	3	6
14	R:R:H99	5.925	4	0	5
15	R:R:H113	6.91	5	2	8
16	R:R:R121	7.175	4	0	9
17	R:R:Y122	11.2825	4	0	8
18	R:R:Y131	6.37	4	6	7
19	R:R:M135	5.4525	4	6	7
20	R:R:V150	4.35	4	0	4
21	R:R:F160	4.7175	4	0	4
22	R:R:F165	6.505	4	1	4
23	R:R:Y172	6.6025	4	1	3
24	R:R:F185	9.396	5	1	1
25	R:R:F186	7.405	4	1	1
26	R:R:F195	6.868	5	1	5
27	R:R:F199	10.2375	4	1	8
28	R:R:Y210	5.132	5	0	9
29	R:R:Y214	4.2475	4	0	5
30	R:R:W264	8.2	6	1	8
31	R:R:F267	7.97167	6	1	5
32	R:R:F268	9.775	4	1	7
33	R:R:I290	6.625	4	1	5
34	R:R:W291	9.31167	6	4	4
35	R:R:Y294	9.992	5	0	7
36	R:R:N300	7.748	5	2	9
37	R:R:Y304	7.56	4	0	9
38	R:R:F306	4.36	4	0	6
39	R:R:Y308	7.4325	4	0	8
40	R:R:W310	9.02	4	0	6
41	R:R:F311	8.264	5	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D103	16.8885	15.68	Yes	No	0	0	6
2	R:R:W291	R:R:Y294	21.7238	11.58	Yes	Yes	0	4	7
3	R:R:I290	R:R:Y294	14.7664	6.04	Yes	Yes	0	5	7
4	R:R:M77	R:R:Y294	17.8937	14.37	Yes	Yes	0	7	7
5	R:R:D103	R:R:V76	12.123	11.69	No	Yes	0	6	7
6	R:R:L72	R:R:V76	26.0704	4.47	Yes	Yes	0	7	7
7	R:R:L72	R:R:S297	40.5482	7.51	Yes	No	0	7	9
8	R:R:D69	R:R:S297	40.7576	7.36	Yes	No	0	9	9
9	R:R:D69	R:R:N41	16.6651	6.73	Yes	No	0	9	9
10	L:L:?1	R:R:S107	42.9589	10.21	Yes	No	0	0	6
11	R:R:S107	R:R:W264	43.4661	4.94	No	Yes	0	6	8
12	R:R:N296	R:R:W264	100	9.04	No	Yes	0	9	8
13	R:R:N296	R:R:N300	100	8.17	No	Yes	0	9	9
14	R:R:D69	R:R:N300	13.6355	8.08	Yes	Yes	2	9	9
15	L:L:?1	R:R:F267	72.7615	16.56	Yes	Yes	1	0	5
16	R:R:F267	R:R:W264	55.0121	7.02	Yes	Yes	1	5	8
17	R:R:M65	R:R:N300	56.2081	8.41	Yes	Yes	2	9	9
18	R:R:M65	R:R:Y304	64.1381	5.99	Yes	Yes	0	9	9
19	R:R:I117	R:R:Y304	90.4458	6.04	No	Yes	0	9	9
20	R:R:I117	R:R:R121	79.8446	5.01	No	Yes	0	9	9
21	R:R:R121	R:R:Y308	80.9894	11.32	Yes	Yes	0	9	8
22	R:R:W310	R:R:Y308	66.3021	12.54	Yes	Yes	0	6	8
23	R:R:F311	R:R:W310	21.4352	11.02	Yes	Yes	0	9	6
24	R:R:L114	R:R:N300	45.5231	9.61	No	Yes	0	9	9
25	R:R:L114	R:R:Y304	39.6454	9.38	No	Yes	0	9	9
26	R:R:F267	R:R:F268	36.1458	5.36	Yes	Yes	1	5	7
27	R:R:F199	R:R:F268	31.2035	20.36	Yes	Yes	1	8	7
28	R:R:F199	R:R:F260	34.7775	7.5	Yes	No	0	8	9
29	R:R:F260	R:R:M206	35.1126	6.22	No	No	0	9	9
30	R:R:M206	R:R:S118	40.0316	6.13	No	No	0	9	8
31	R:R:S118	R:R:Y210	31.0964	6.36	No	Yes	0	8	9
32	R:R:R121	R:R:Y210	27.8202	7.2	Yes	Yes	0	9	9
33	R:R:N59	R:R:W310	42.0281	10.17	Yes	Yes	0	9	6
34	R:R:I48	R:R:N59	23.8226	7.08	No	Yes	0	7	9
35	R:R:H63	R:R:I48	21.4818	6.63	Yes	No	0	6	7
36	R:R:L54	R:R:N59	14.2638	5.49	Yes	Yes	0	8	9
37	R:R:H63	R:R:W60	12.0253	6.35	Yes	No	0	6	4
38	R:R:I117	R:R:L61	22.5009	4.28	No	No	0	9	7
39	R:R:R121	R:R:T58	16.7396	5.17	Yes	No	0	9	8
40	R:R:D120	R:R:T58	14.4872	7.23	No	No	0	9	8
41	R:R:H113	R:R:M65	35.0614	5.25	Yes	Yes	2	8	9
42	R:R:H113	R:R:S147	23.9296	13.95	Yes	No	0	8	7
43	R:R:F116	R:R:S147	22.7522	6.61	No	No	0	7	7
44	R:R:F116	R:R:M143	12.6536	19.9	No	No	0	7	6
45	R:R:L61	R:R:M143	16.9443	4.24	No	No	0	7	6
46	R:R:L106	R:R:L72	22.0262	5.54	No	Yes	0	6	7
47	L:L:?1	R:R:R83	15.6646	9.08	Yes	No	0	0	4
48	R:R:R83	R:R:W89	12.9421	6	No	Yes	0	4	7
49	R:R:H99	R:R:W89	10.8945	6.35	Yes	Yes	0	5	7
50	R:R:H99	R:R:V76	16.707	4.15	Yes	Yes	0	5	7
51	R:R:H99	R:R:Y79	10.0568	7.62	Yes	Yes	0	5	5
52	R:R:F91	R:R:V82	11.0713	7.87	Yes	No	0	6	5
53	R:R:L106	R:R:M105	20.5091	4.24	No	No	0	6	5
54	R:R:F156	R:R:M105	17.4469	4.98	No	No	0	4	5
55	R:R:F156	R:R:F160	12.7885	6.43	No	Yes	0	4	4
56	R:R:F116	R:R:I146	20.928	6.28	No	No	0	7	3
57	R:R:I146	R:R:V150	17.8099	3.07	No	Yes	0	3	4
58	R:R:P151	R:R:V150	11.4622	3.53	No	Yes	0	8	4
59	R:R:I111	R:R:W264	14.0125	11.74	No	Yes	0	8	8
60	R:R:I111	R:R:P202	11.6996	3.39	No	No	0	8	9
61	R:R:S118	R:R:V209	19.6109	6.46	No	No	0	8	7
62	R:R:M143	R:R:V139	14.9525	1.52	No	No	0	6	5
63	R:R:V209	R:R:Y122	18.3684	7.57	No	Yes	0	7	8
64	L:L:?1	R:R:F186	62.393	6.62	Yes	Yes	1	0	1
65	R:R:F186	R:R:N164	49.9535	7.25	Yes	No	1	1	4
66	L:L:?1	R:R:V184	51.8894	9.11	Yes	No	1	0	4
67	R:R:N164	R:R:V184	49.4462	4.43	No	No	1	4	4
68	R:R:F165	R:R:N164	94.4015	3.62	Yes	No	1	4	4
69	R:R:E169	R:R:F165	10.6338	4.66	No	Yes	0	4	4
70	R:R:F165	R:R:Y172	21.0303	12.38	Yes	Yes	1	4	3
71	R:R:F165	R:R:F185	57.8416	5.36	Yes	Yes	1	4	1
72	R:R:F185	R:R:I171	21.2351	6.28	Yes	No	0	1	2
73	R:R:I171	R:R:K174	10.6338	5.82	No	No	0	2	4
74	R:R:F185	R:R:H175	10.6338	14.71	Yes	No	0	1	3
75	R:R:F267	R:R:L289	17.1258	6.09	Yes	No	0	5	5
76	R:R:C270	R:R:L289	15.2597	3.17	No	No	0	4	5
77	R:R:C270	R:R:I281	13.3842	3.27	No	No	0	4	2
78	R:R:F185	R:R:Y279	21.2351	12.38	Yes	No	0	1	1
79	R:R:F186	R:R:S190	10.8107	2.64	Yes	No	0	1	6
80	R:R:P275	R:R:Y279	15.9391	5.56	No	No	0	4	1
81	R:R:K188	R:R:P275	10.6338	3.35	No	No	0	3	4
82	R:R:L253	R:R:Y210	10.3546	3.52	No	Yes	0	7	9
83	R:R:V303	R:R:Y304	13.0631	8.83	No	Yes	0	8	9
84	R:R:V259	R:R:V303	10.9084	4.81	No	No	0	6	8
85	R:R:Y172	R:R:Y173	10.6338	1.99	Yes	No	0	3	2
86	R:R:L72	R:R:M77	17.7494	4.24	Yes	Yes	0	7	7
87	R:R:D69	R:R:M65	34.4937	4.16	Yes	Yes	2	9	9
88	R:R:L114	R:R:M206	12.7978	4.24	No	No	0	9	9
89	R:R:F267	R:R:I290	11.895	5.02	Yes	Yes	1	5	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:R83	9.08	1	Yes	No	0	4	0	1
L:L:?1	R:R:T100	6.01	1	Yes	No	0	4	0	1
L:L:?1	R:R:D103	15.68	1	Yes	No	0	6	0	1
L:L:?1	R:R:I104	7.76	1	Yes	No	0	4	0	1
L:L:?1	R:R:S107	10.21	1	Yes	No	0	6	0	1
L:L:?1	R:R:V184	9.11	1	Yes	No	0	4	0	1
L:L:?1	R:R:F186	6.62	1	Yes	Yes	0	1	0	1
L:L:?1	R:R:F267	16.56	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:I290	12.61	1	Yes	Yes	0	5	0	1
R:R:D103	R:R:V76	11.69	0	No	Yes	6	7	1	2
R:R:R83	R:R:S80	9.22	0	No	No	4	6	1	2
R:R:S80	R:R:Y294	7.63	0	No	Yes	6	7	2	2
R:R:R83	R:R:W89	6	0	No	Yes	4	7	1	2
R:R:D103	R:R:Y294	10.34	0	No	Yes	6	7	1	2
R:R:S107	R:R:W264	4.94	0	No	Yes	6	8	1	2
R:R:N164	R:R:V184	4.43	1	No	No	4	4	2	1
R:R:F186	R:R:N164	7.25	1	Yes	No	1	4	1	2
R:R:F186	R:R:V184	13.11	1	Yes	No	1	4	1	1
R:R:F267	R:R:W264	7.02	1	Yes	Yes	5	8	1	2
R:R:F268	R:R:W264	8.02	1	Yes	Yes	7	8	2	2
R:R:F267	R:R:F268	5.36	1	Yes	Yes	5	7	1	2
R:R:F267	R:R:T271	7.78	1	Yes	No	5	5	1	2
R:R:F267	R:R:L289	6.09	1	Yes	No	5	5	1	2
R:R:F267	R:R:I290	5.02	1	Yes	Yes	5	5	1	1
R:R:I290	R:R:Y294	6.04	1	Yes	Yes	5	7	1	2
R:R:A155	R:R:I104	3.25	0	No	No	6	4	2	1
R:R:I290	R:R:N286	2.83	1	Yes	No	5	4	1	2
R:R:F186	R:R:S190	2.64	1	Yes	No	1	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8JLQ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	4.14
Number of Linked Nodes	266
Number of Links	290
Number of Hubs	41
Number of Links mediated by Hubs	151
Number of Communities	6
Number of Nodes involved in Communities	37
Number of Links involved in Communities	47

Path Summary
Number Of Nodes in MetaPath	90
Number Of Links MetaPath	89
Number of Shortest Paths	60599
Length Of Smallest Path	3
Average Path Length	12.6994
Length of Longest Path	25
Minimum Path Strength	1.3
Average Path Strength	7.29573
Maximum Path Strength	16.965
Minimum Path Correlation	0.7
Average Path Correlation	0.933166
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.26316
Average % Of Corr. Nodes	56.6928
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	50.2211
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • D2 dopamine receptor binding • adenylate cyclase inhibitor activity • molecular function inhibitor activity • cyclase inhibitor activity • enzyme inhibitor activity • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • negative regulation of peptide hormone secretion • negative regulation of establishment of protein localization • negative regulation of protein secretion • negative regulation of signaling • negative regulation of cell communication • negative regulation of peptide secretion • negative regulation of cellular process • negative regulation of protein localization • negative regulation of insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • synapse • cell junction • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • G protein-coupled amine receptor activity • molecular transducer activity • trace-amine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • electron transport chain • metabolic process • generation of precursor metabolites and energy • phospholipase C-activating G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • periplasmic space • endoplasmic reticulum subcompartment • nuclear outer membrane-endoplasmic reticulum membrane network • endoplasmic reticulum • endoplasmic reticulum membrane • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	G3C
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	G3C
Name	(1R)-6-chloranyl-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol
Synonyms
Identifier
Formula	C16 H16 Cl N O3
Molecular Weight	305.756
SMILES
PubChem	12668023
Formal Charge	0
Total Atoms	37
Total Chiral Atoms	1
Total Bonds	39
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q96RJ0
Sequence	>8JLQ_nogp_Chain_R V R A S L Y S L M V L I I L T T L V G N L I V I V S I S H F K Q L H T P T N W L I H S M A T V D F L L G C L V M P Y S M V R S A E H C W Y F G E V F C K I H T S T D I M L S S A S I F H L S F I S I D R Y Y A V C D P L R Y K A K M N I L V I C V M I F I S W S V P A V F A F G M I F L E L N F K G A E E I Y Y K H V H C R G G C S V F F S K I S G V L T F M T S F Y I P G S I M L C V Y Y R I Y L I A K E Q A R L I S D A N Q K L Q K A V K T L G I V M G V F L I C W C P F F I C T V M D P F L H Y I I P P T L N D V L I W F G Y L N S T F N P M V Y A F F Y P W F R K A L K M M L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8WC3	A	Amine	Trace Amine Receptors	TA1	Mus musculus	SEP-363856	-	chim(NtGi1-Gs)/β1/γ2	3	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC3 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	SEP-363856	-		3	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC4	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8651	-	chim(NtGi1-Gs)/β1/γ2	3.1	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC4 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8651	-		3.1	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC5	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Tetramethylammonium Ion	-	chim(NtGi1-Gs)/β1/γ2	3.3	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC5 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Tetramethylammonium Ion	-		3.3	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC6	A	Amine	Trace Amine Receptors	TA1	Mus musculus	2-Phenylethylamine	-	chim(NtGi1-Gs)/β1/γ2	3.2	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC6 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	2-Phenylethylamine	-		3.2	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC7	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8667	-	chim(NtGi1-Gs)/β1/γ2	3.1	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC7 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8667	-		3.1	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC8	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	ZH8651	-	chim(NtGi1-Gs)/β1/γ2	2.9	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC8 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	ZH8651	-		2.9	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC9	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8651	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.2	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC9 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	ZH8651	-		3.2	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WCA	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	2-Phenylethylamine	-	chim(NtGi1-Gs)/β1/γ2	3.48	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WCA (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	2-Phenylethylamine	-		3.48	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WCB	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Cyclohexylammonium Ion	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WCB (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Cyclohexylammonium Ion	-		3.1	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WCC	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Cyclohexylammonium Ion	-	-	3.04	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8ZSJ	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	-	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	2.8	2024-07-24	doi.org/10.1016/j.celrep.2024.114505
	8ZSJ (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	-	-		2.8	2024-07-24	doi.org/10.1016/j.celrep.2024.114505
	8ZSP	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	LSD	-	chim(NtGi1L-Gs-CtGq)/β1/γ2	3.14	2024-07-24	doi.org/10.1016/j.celrep.2024.114505
	8ZSP (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	LSD	-		3.14	2024-07-24	doi.org/10.1016/j.celrep.2024.114505
	8ZSS	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5263397	-	chim(NtGi1-Gs)/β1/γ2	3.07	2024-07-24	doi.org/10.1016/j.celrep.2024.114505
	8ZSS (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5263397	-		3.07	2024-07-24	doi.org/10.1016/j.celrep.2024.114505
	8ZSV	A	Amine	Trace Amine Receptors	TA1	Mus musculus	RO5263397	-	chim(NtGi1-Gs)/β1/γ2	2.96	2024-07-24	doi.org/10.1016/j.celrep.2024.114505
	8ZSV (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	RO5263397	-		2.96	2024-07-24	doi.org/10.1016/j.celrep.2024.114505
	8UHB	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5256390	-	Gs/β1/γ2	3.35	2024-01-10	doi.org/10.1038/s41467-023-44601-4
	8UHB (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5256390	-		3.35	2024-01-10	doi.org/10.1038/s41467-023-44601-4
	8W87	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	METH	-	chim(NtGi1L-Gs)/β1/γ2	2.8	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W87 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	METH	-		2.8	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W88	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	SEP-363856	-	Gs/β1/γ2	2.6	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W88 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	SEP-363856	-		2.6	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W89	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	PEA	-	chim(NtGi1L-Gs)/β1/γ2	3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W89 (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	PEA	-		3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W8A	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5256390	-	chim(NtGi1L-Gs)/β1/γ2	2.8	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W8A (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	RO5256390	-		2.8	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8JLJ	A	Amine	Trace Amine Receptors	TA1	Mus musculus	T1AM	-	chim(NtGi1-Gs)/β1/γ2	3.1	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLJ (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	T1AM	-		3.1	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLK	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Ulotaront	-	chim(NtGi1-Gs)/β1/γ2	3.22	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLK (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Mus musculus	Ulotaront	-		3.22	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLN	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	T1AM	-	Gs/β1/γ2	3.24	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLN (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	T1AM	-		3.24	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLO	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Ulotaront	-	Gs/β1/γ2	3.52	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLO (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Ulotaront	-		3.52	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLP	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Ralmitaront	-	Gs/β1/γ2	3.23	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLP (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Ralmitaront	-		3.23	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLQ	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Fenoldopam	-	Gs/β1/γ2	2.84	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLQ (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	Fenoldopam	-		2.84	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLR	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	A77636	-	chim(NtGi1-Gs)/β1/γ2	3	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLR (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	A77636	-		3	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JSO	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	AMPH	-	chim(NtGi1-Gs)/β1/γ2	3.4	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JSO (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	AMPH	-		3.4	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	9JKQ	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	METH	-	Gs/β1/γ2	2.66	2024-10-16	doi.org/10.1021/acs.jmedchem.4c01961
	9JKQ (No Gprot)	A	Amine	Trace Amine Receptors	TA1	Homo sapiens	METH	-		2.66	2024-10-16	doi.org/10.1021/acs.jmedchem.4c01961

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