Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7CKW | A | Amine | Dopamine | D1 | Homo sapiens | Fenoldopam | - | Gs/Beta1/Gamma2 | 3.22 | 2021-03-03 | 10.1016/j.cell.2021.01.028 |
![](/psngpcr/ligands/G3C/G3C_7CKW_L_L_1.png)
A 2D representation of the interactions of G3C in 7CKW colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:D103 | R:R:V77 | 7.3 | 1 | Yes | No | 7 | 8 | 1 | 2 | R:R:V77 | R:R:W321 | 4.9 | 1 | No | Yes | 8 | 7 | 2 | 2 | R:R:D103 | R:R:S107 | 5.89 | 1 | Yes | No | 7 | 7 | 1 | 1 | R:R:D103 | R:R:W321 | 12.28 | 1 | Yes | Yes | 7 | 7 | 1 | 2 | L:L:?1 | R:R:D103 | 15.38 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:I104 | R:R:S155 | 6.19 | 0 | No | No | 6 | 7 | 1 | 2 | L:L:?1 | R:R:I104 | 5.71 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:S107 | R:R:W285 | 7.41 | 1 | No | Yes | 7 | 8 | 1 | 2 | L:L:?1 | R:R:S107 | 6.01 | 1 | Yes | No | 0 | 7 | 0 | 1 | R:R:I154 | R:R:T108 | 4.56 | 0 | No | No | 5 | 6 | 2 | 2 | R:R:S202 | R:R:T108 | 7.99 | 1 | No | No | 6 | 6 | 1 | 2 | R:R:I154 | R:R:S198 | 6.19 | 0 | No | No | 5 | 7 | 2 | 1 | R:R:H164 | R:R:L190 | 5.14 | 0 | Yes | No | 5 | 4 | 2 | 1 | R:R:H164 | R:R:Y194 | 6.53 | 0 | Yes | Yes | 5 | 7 | 2 | 2 | L:L:?1 | R:R:L190 | 19.38 | 1 | Yes | No | 0 | 4 | 0 | 1 | R:R:S198 | R:R:Y194 | 11.45 | 0 | No | Yes | 7 | 7 | 1 | 2 | L:L:?1 | R:R:S198 | 8.01 | 1 | Yes | No | 0 | 7 | 0 | 1 | R:R:F289 | R:R:S199 | 5.28 | 1 | Yes | No | 7 | 7 | 1 | 1 | R:R:N292 | R:R:S199 | 7.45 | 1 | No | No | 6 | 7 | 1 | 1 | L:L:?1 | R:R:S199 | 5.01 | 1 | Yes | No | 0 | 7 | 0 | 1 | R:R:F289 | R:R:S202 | 6.61 | 1 | Yes | No | 7 | 6 | 1 | 1 | L:L:?1 | R:R:S202 | 5.01 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:F203 | R:R:F289 | 22.51 | 0 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:F289 | R:R:W285 | 7.02 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:F288 | R:R:F289 | 15 | 1 | Yes | Yes | 7 | 7 | 1 | 1 | R:R:F288 | R:R:N292 | 9.67 | 1 | Yes | No | 7 | 6 | 1 | 1 | R:R:F288 | R:R:F313 | 5.36 | 1 | Yes | Yes | 7 | 4 | 1 | 2 | L:L:?1 | R:R:F288 | 12.18 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:F289 | 4.87 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:N292 | 13.73 | 1 | Yes | No | 0 | 6 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 10.00 | Average Number Of Links With An Hub | 3.00 | Average Interaction Strength | 9.53 | Average Nodes In Shell | 21.00 | Average Hubs In Shell | 10.00 | Average Links In Shell | 30.00 | Average Links Mediated by Hubs In Shell | 25.00 |
| ![](/psngpcr/ligands/G3C/G3C_7CKW_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/G3C/G3C_7CKW_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7X2C | A | Amine | Dopamine | D1 | Homo sapiens | Fenoldopam | Fenoldopam | Gs/Beta1/Gamma2 | 3.2 | 2022-06-29 | 10.1038/s41467-022-30929-w |
![](/psngpcr/ligands/G3C/G3C_7X2C_W_W_1.png)
A 2D representation of the interactions of G3C in 7X2C colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:V77 | R:R:W99 | 4.9 | 1 | No | Yes | 8 | 5 | 2 | 1 | R:R:D103 | R:R:V77 | 4.38 | 1 | Yes | No | 7 | 8 | 1 | 2 | R:R:V77 | R:R:W321 | 8.58 | 1 | No | Yes | 8 | 7 | 2 | 2 | R:R:F95 | R:R:W80 | 10.02 | 1 | Yes | Yes | 5 | 5 | 2 | 2 | R:R:W80 | R:R:W99 | 7.5 | 1 | Yes | Yes | 5 | 5 | 2 | 1 | R:R:E85 | R:R:K81 | 4.05 | 1 | No | Yes | 4 | 6 | 2 | 1 | R:R:K81 | R:R:W99 | 3.48 | 1 | Yes | Yes | 6 | 5 | 1 | 1 | R:R:D314 | R:R:K81 | 5.53 | 1 | No | Yes | 4 | 6 | 1 | 1 | R:R:K81 | R:R:W318 | 9.28 | 1 | Yes | No | 6 | 5 | 1 | 2 | R:R:K81 | R:R:W321 | 5.8 | 1 | Yes | Yes | 6 | 7 | 1 | 2 | R:R:K81 | W:W:?1 | 8.46 | 1 | Yes | Yes | 6 | 0 | 1 | 0 | R:R:D314 | R:R:E85 | 9.09 | 1 | No | No | 4 | 4 | 1 | 2 | R:R:W90 | R:R:W99 | 7.5 | 1 | Yes | Yes | 8 | 5 | 2 | 1 | R:R:F95 | R:R:W99 | 4.01 | 1 | Yes | Yes | 5 | 5 | 2 | 1 | R:R:V100 | R:R:W99 | 3.68 | 0 | No | Yes | 5 | 5 | 2 | 1 | R:R:W99 | W:W:?1 | 8.35 | 1 | Yes | Yes | 5 | 0 | 1 | 0 | R:R:D103 | R:R:W321 | 12.28 | 1 | Yes | Yes | 7 | 7 | 1 | 2 | R:R:D103 | W:W:?1 | 4.52 | 1 | Yes | Yes | 7 | 0 | 1 | 0 | L:L:?1 | R:R:D103 | 17.19 | 1 | Yes | Yes | 0 | 7 | 1 | 1 | L:L:?1 | R:R:I104 | 21.89 | 1 | Yes | No | 0 | 6 | 1 | 2 | L:L:?1 | R:R:S107 | 7.01 | 1 | Yes | No | 0 | 7 | 1 | 2 | R:R:S189 | W:W:?1 | 4 | 0 | No | Yes | 4 | 0 | 1 | 0 | R:R:L190 | R:R:N292 | 5.49 | 1 | No | Yes | 4 | 6 | 2 | 2 | L:L:?1 | R:R:L190 | 17.53 | 1 | Yes | No | 0 | 4 | 1 | 2 | L:L:?1 | R:R:S198 | 9.01 | 1 | Yes | No | 0 | 7 | 1 | 2 | L:L:?1 | R:R:S202 | 4 | 1 | Yes | No | 0 | 6 | 1 | 2 | R:R:F288 | R:R:F289 | 8.57 | 1 | Yes | Yes | 7 | 7 | 2 | 2 | R:R:F288 | R:R:N292 | 3.62 | 1 | Yes | Yes | 7 | 6 | 2 | 2 | R:R:F288 | R:R:F313 | 4.29 | 1 | Yes | No | 7 | 4 | 2 | 1 | L:L:?1 | R:R:F288 | 11.37 | 1 | Yes | Yes | 0 | 7 | 1 | 2 | L:L:?1 | R:R:F289 | 6.5 | 1 | Yes | Yes | 0 | 7 | 1 | 2 | L:L:?1 | R:R:N292 | 3.66 | 1 | Yes | Yes | 0 | 6 | 1 | 2 | R:R:F313 | W:W:?1 | 5.68 | 0 | No | Yes | 4 | 0 | 1 | 0 | R:R:D314 | W:W:?1 | 9.95 | 1 | No | Yes | 4 | 0 | 1 | 0 | R:R:W318 | R:R:W321 | 8.43 | 1 | No | Yes | 5 | 7 | 2 | 2 | L:L:?1 | R:R:W321 | 5.32 | 1 | Yes | Yes | 0 | 7 | 1 | 2 | L:L:?1 | W:W:?1 | 30.77 | 1 | Yes | Yes | 0 | 0 | 1 | 0 | R:R:S310 | W:W:?1 | 3 | 0 | No | Yes | 1 | 0 | 1 | 0 | R:R:D187 | W:W:?1 | 0.9 | 0 | No | Yes | 5 | 0 | 1 | 0 | |
Statistics | Value |
---|
Average Number Of Links | 9.00 | Average Number Of Links With An Hub | 4.00 | Average Interaction Strength | 8.40 | Average Nodes In Shell | 26.00 | Average Hubs In Shell | 12.00 | Average Links In Shell | 39.00 | Average Links Mediated by Hubs In Shell | 38.00 |
| ![](/psngpcr/ligands/G3C/G3C_7X2C_W_W_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/G3C/G3C_7X2C_W_W_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
![](/psngpcr/ligands/G3C/G3C_7X2C_L_L_1.png)
A 2D representation of the interactions of G3C in 7X2C colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:V77 | R:R:W99 | 4.9 | 1 | No | Yes | 8 | 5 | 2 | 2 | R:R:D103 | R:R:V77 | 4.38 | 1 | Yes | No | 7 | 8 | 1 | 2 | R:R:V77 | R:R:W321 | 8.58 | 1 | No | Yes | 8 | 7 | 2 | 1 | R:R:M78 | R:R:W321 | 6.98 | 0 | No | Yes | 7 | 7 | 2 | 1 | R:R:K81 | R:R:W99 | 3.48 | 1 | Yes | Yes | 6 | 5 | 2 | 2 | R:R:D314 | R:R:K81 | 5.53 | 1 | No | Yes | 4 | 6 | 2 | 2 | R:R:K81 | R:R:W318 | 9.28 | 1 | Yes | No | 6 | 5 | 2 | 2 | R:R:K81 | R:R:W321 | 5.8 | 1 | Yes | Yes | 6 | 7 | 2 | 1 | R:R:K81 | W:W:?1 | 8.46 | 1 | Yes | Yes | 6 | 0 | 2 | 1 | R:R:W99 | W:W:?1 | 8.35 | 1 | Yes | Yes | 5 | 0 | 2 | 1 | R:R:D103 | R:R:W321 | 12.28 | 1 | Yes | Yes | 7 | 7 | 1 | 1 | R:R:D103 | W:W:?1 | 4.52 | 1 | Yes | Yes | 7 | 0 | 1 | 1 | L:L:?1 | R:R:D103 | 17.19 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:I104 | R:R:S155 | 6.19 | 0 | No | No | 6 | 7 | 1 | 2 | R:R:I104 | R:R:Y194 | 3.63 | 0 | No | Yes | 6 | 7 | 1 | 2 | L:L:?1 | R:R:I104 | 21.89 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:S107 | R:R:W285 | 4.94 | 0 | No | Yes | 7 | 8 | 1 | 2 | L:L:?1 | R:R:S107 | 7.01 | 1 | Yes | No | 0 | 7 | 0 | 1 | R:R:S202 | R:R:T108 | 9.59 | 0 | No | No | 6 | 6 | 1 | 2 | R:R:H164 | R:R:L190 | 3.86 | 0 | Yes | No | 5 | 4 | 2 | 1 | R:R:H164 | R:R:Y194 | 4.36 | 0 | Yes | Yes | 5 | 7 | 2 | 2 | R:R:S189 | W:W:?1 | 4 | 0 | No | Yes | 4 | 0 | 2 | 1 | R:R:L190 | R:R:N292 | 5.49 | 1 | No | Yes | 4 | 6 | 1 | 1 | L:L:?1 | R:R:L190 | 17.53 | 1 | Yes | No | 0 | 4 | 0 | 1 | R:R:S198 | R:R:Y194 | 7.63 | 0 | No | Yes | 7 | 7 | 1 | 2 | L:L:?1 | R:R:S198 | 9.01 | 1 | Yes | No | 0 | 7 | 0 | 1 | R:R:F289 | R:R:S199 | 6.61 | 1 | Yes | No | 7 | 7 | 1 | 2 | R:R:N292 | R:R:S199 | 5.96 | 1 | Yes | No | 6 | 7 | 1 | 2 | L:L:?1 | R:R:S202 | 4 | 1 | Yes | No | 0 | 6 | 0 | 1 | R:R:F203 | R:R:W285 | 4.01 | 1 | Yes | Yes | 8 | 8 | 2 | 2 | R:R:F203 | R:R:F289 | 21.43 | 1 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:F288 | R:R:W285 | 6.01 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:F289 | R:R:W285 | 6.01 | 1 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:F288 | R:R:F289 | 8.57 | 1 | Yes | Yes | 7 | 7 | 1 | 1 | R:R:F288 | R:R:N292 | 3.62 | 1 | Yes | Yes | 7 | 6 | 1 | 1 | R:R:F288 | R:R:F313 | 4.29 | 1 | Yes | No | 7 | 4 | 1 | 2 | R:R:F288 | R:R:V317 | 3.93 | 1 | Yes | No | 7 | 6 | 1 | 2 | L:L:?1 | R:R:F288 | 11.37 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:F289 | 6.5 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | R:R:N292 | 3.66 | 1 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:F313 | W:W:?1 | 5.68 | 0 | No | Yes | 4 | 0 | 2 | 1 | R:R:D314 | W:W:?1 | 9.95 | 1 | No | Yes | 4 | 0 | 2 | 1 | R:R:W318 | R:R:W321 | 8.43 | 1 | No | Yes | 5 | 7 | 2 | 1 | L:L:?1 | R:R:W321 | 5.32 | 1 | Yes | Yes | 0 | 7 | 0 | 1 | L:L:?1 | W:W:?1 | 30.77 | 1 | Yes | Yes | 0 | 0 | 0 | 1 | R:R:I154 | R:R:S155 | 3.1 | 0 | No | No | 5 | 7 | 2 | 2 | R:R:I154 | R:R:S198 | 3.1 | 0 | No | No | 5 | 7 | 2 | 1 | R:R:S310 | W:W:?1 | 3 | 0 | No | Yes | 1 | 0 | 2 | 1 | R:R:D187 | W:W:?1 | 0.9 | 0 | No | Yes | 5 | 0 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 11.00 | Average Number Of Links With An Hub | 6.00 | Average Interaction Strength | 12.20 | Average Nodes In Shell | 31.00 | Average Hubs In Shell | 13.00 | Average Links In Shell | 49.00 | Average Links Mediated by Hubs In Shell | 45.00 |
| ![](/psngpcr/ligands/G3C/G3C_7X2C_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/G3C/G3C_7X2C_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8JLQ | A | Amine | Trace amine receptors | TA1 | Homo Sapiens | Fenoldopam | - | Gs/Beta1/Gamma2 | 2.84 | 2023-11-15 | 10.1038/s41586-023-06804-z |
![](/psngpcr/ligands/G3C/G3C_8JLQ_L_L_1.png)
A 2D representation of the interactions of G3C in 8JLQ colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:D103 | R:R:V76 | 11.69 | 2 | No | Yes | 6 | 7 | 1 | 2 | R:R:V76 | R:R:Y294 | 3.79 | 2 | Yes | Yes | 7 | 7 | 2 | 2 | R:R:R83 | R:R:S80 | 9.22 | 0 | No | No | 4 | 6 | 1 | 2 | R:R:S80 | R:R:Y294 | 7.63 | 0 | No | Yes | 6 | 7 | 2 | 2 | R:R:R83 | R:R:W89 | 6 | 0 | No | Yes | 4 | 7 | 1 | 2 | L:L:?1 | R:R:R83 | 8.91 | 2 | Yes | No | 0 | 4 | 0 | 1 | L:L:?1 | R:R:T100 | 5.9 | 2 | Yes | No | 0 | 4 | 0 | 1 | R:R:D103 | R:R:Y294 | 10.34 | 2 | No | Yes | 6 | 7 | 1 | 2 | L:L:?1 | R:R:D103 | 15.38 | 2 | Yes | No | 0 | 6 | 0 | 1 | L:L:?1 | R:R:I104 | 7.61 | 2 | Yes | No | 0 | 4 | 0 | 1 | R:R:S107 | R:R:W264 | 4.94 | 0 | No | Yes | 6 | 8 | 1 | 2 | L:L:?1 | R:R:S107 | 10.01 | 2 | Yes | No | 0 | 6 | 0 | 1 | R:R:N164 | R:R:V184 | 4.43 | 2 | No | No | 4 | 4 | 2 | 1 | R:R:F186 | R:R:N164 | 7.25 | 2 | Yes | No | 1 | 4 | 1 | 2 | R:R:F186 | R:R:V184 | 13.11 | 2 | Yes | No | 1 | 4 | 1 | 1 | L:L:?1 | R:R:V184 | 8.94 | 2 | Yes | No | 0 | 4 | 0 | 1 | L:L:?1 | R:R:F186 | 6.5 | 2 | Yes | Yes | 0 | 1 | 0 | 1 | R:R:F195 | R:R:F199 | 7.5 | 2 | Yes | Yes | 5 | 8 | 2 | 2 | R:R:F195 | R:R:F268 | 5.36 | 2 | Yes | Yes | 5 | 7 | 2 | 1 | R:R:F199 | R:R:W264 | 4.01 | 2 | Yes | Yes | 8 | 8 | 2 | 2 | R:R:F199 | R:R:F268 | 20.36 | 2 | Yes | Yes | 8 | 7 | 2 | 1 | R:R:F267 | R:R:W264 | 7.02 | 2 | Yes | Yes | 5 | 8 | 1 | 2 | R:R:F268 | R:R:W264 | 8.02 | 2 | Yes | Yes | 7 | 8 | 1 | 2 | R:R:F267 | R:R:F268 | 5.36 | 2 | Yes | Yes | 5 | 7 | 1 | 1 | R:R:F267 | R:R:T271 | 7.78 | 2 | Yes | No | 5 | 5 | 1 | 2 | R:R:F267 | R:R:L289 | 6.09 | 2 | Yes | No | 5 | 5 | 1 | 2 | R:R:F267 | R:R:I290 | 5.02 | 2 | Yes | Yes | 5 | 5 | 1 | 1 | L:L:?1 | R:R:F267 | 16.24 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:?1 | R:R:F268 | 4.06 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:I290 | R:R:Y294 | 6.04 | 2 | Yes | Yes | 5 | 7 | 1 | 2 | L:L:?1 | R:R:I290 | 12.37 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:A155 | R:R:I104 | 3.25 | 0 | No | No | 6 | 4 | 2 | 1 | R:R:I290 | R:R:N286 | 2.83 | 2 | Yes | No | 5 | 4 | 1 | 2 | R:R:F186 | R:R:S190 | 2.64 | 2 | Yes | No | 1 | 6 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 10.00 | Average Number Of Links With An Hub | 4.00 | Average Interaction Strength | 9.59 | Average Nodes In Shell | 24.00 | Average Hubs In Shell | 11.00 | Average Links In Shell | 34.00 | Average Links Mediated by Hubs In Shell | 31.00 |
| ![](/psngpcr/ligands/G3C/G3C_8JLQ_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/G3C/G3C_8JLQ_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|