psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D103	13.39	Yes	No	1	0	6
2	L:L:?1	R:R:I104	14.08	Yes	No	0	0	4
3	L:L:?1	R:R:S107	12.53	Yes	No	1	0	6
4	L:L:?1	R:R:F186	6.47	Yes	Yes	1	0	1
5	L:L:?1	R:R:T194	4.47	Yes	No	1	0	5
6	L:L:?1	R:R:W264	9.51	Yes	Yes	1	0	8
7	L:L:?1	R:R:F267	20.33	Yes	Yes	1	0	5
8	L:L:?1	R:R:F268	5.54	Yes	Yes	1	0	7
9	L:L:?1	R:R:I290	14.08	Yes	No	1	0	5
10	L:L:?1	R:R:Y294	9.78	Yes	Yes	1	0	7
11	R:R:V31	R:R:Y27	7.57	No	No	0	5	6
12	R:R:M81	R:R:Y27	5.99	No	No	0	6	6
13	R:R:M30	R:R:M81	8.66	Yes	No	0	6	6
14	R:R:M30	R:R:S84	4.6	Yes	No	1	6	5
15	R:R:M30	R:R:W291	17.45	Yes	Yes	1	6	4
16	R:R:I33	R:R:W291	7.05	No	Yes	0	7	4
17	R:R:I33	R:R:L295	7.14	No	Yes	0	7	5
18	R:R:I34	R:R:M77	4.37	Yes	Yes	1	6	7
19	R:R:I34	R:R:P78	5.08	Yes	No	0	6	8
20	R:R:I34	R:R:W291	3.52	Yes	Yes	1	6	4
21	R:R:N41	R:R:T37	4.39	No	No	0	9	7
22	R:R:S297	R:R:T37	4.8	No	No	0	9	7
23	R:R:T298	R:R:T37	9.42	No	No	0	7	7
24	R:R:F70	R:R:L38	4.87	No	No	0	7	6
25	R:R:G40	R:R:P301	4.06	No	No	0	9	9
26	R:R:D69	R:R:N41	12.12	Yes	No	0	9	9
27	R:R:N41	R:R:P301	14.66	No	No	0	9	9
28	R:R:F70	R:R:L42	9.74	No	No	0	7	4
29	R:R:F306	R:R:I43	3.77	No	No	0	6	7
30	R:R:H63	R:R:I45	7.95	Yes	No	2	6	8
31	R:R:I45	R:R:T67	4.56	No	Yes	2	8	6
32	R:R:F311	R:R:S47	7.93	Yes	No	0	9	8
33	R:R:I48	R:R:N59	4.25	No	No	0	7	9
34	R:R:I48	R:R:W60	4.7	No	No	2	7	4
35	R:R:H63	R:R:I48	6.63	Yes	No	2	6	7
36	R:R:F51	R:R:H50	9.05	Yes	No	0	5	5
37	R:R:F51	R:R:Q53	8.2	Yes	No	7	5	5
38	R:R:F51	R:R:L54	3.65	Yes	No	7	5	8
39	R:R:L54	R:R:Q53	5.32	No	No	7	8	5
40	R:R:H55	R:R:W60	8.46	No	No	0	8	4
41	R:R:P57	R:R:T56	3.5	No	No	0	6	8
42	R:R:N59	R:R:T56	8.77	No	No	0	9	8
43	R:R:I137	R:R:P57	6.77	No	No	0	2	6
44	R:R:I140	R:R:P57	6.77	No	No	0	7	6
45	R:R:D120	R:R:T58	10.12	Yes	No	6	9	8
46	R:R:T58	R:R:Y131	3.75	No	Yes	6	8	7
47	R:R:N59	R:R:W310	6.78	No	Yes	0	9	6
48	R:R:H63	R:R:W60	9.52	Yes	No	2	6	4
49	R:R:D120	R:R:L61	4.07	Yes	No	0	9	7
50	R:R:I140	R:R:L61	7.14	No	No	0	7	7
51	R:R:L61	R:R:M143	4.24	No	No	0	7	6
52	R:R:H63	R:R:T67	4.11	Yes	Yes	2	6	6
53	R:R:H113	R:R:S64	11.16	Yes	No	2	8	9
54	R:R:I144	R:R:S64	10.84	No	No	0	7	9
55	R:R:S64	R:R:W148	6.18	No	Yes	2	9	9
56	R:R:H113	R:R:M65	7.88	Yes	No	0	8	9
57	R:R:M65	R:R:N300	5.61	No	Yes	0	9	9
58	R:R:M65	R:R:Y304	4.79	No	Yes	0	9	9
59	R:R:T67	R:R:W148	4.85	Yes	Yes	2	6	9
60	R:R:A109	R:R:V68	5.09	No	No	0	7	8
61	R:R:H113	R:R:V68	5.54	Yes	No	2	8	8
62	R:R:V68	R:R:W148	7.36	No	Yes	2	8	9
63	R:R:D69	R:R:S110	5.89	Yes	No	0	9	9
64	R:R:D69	R:R:S297	7.36	Yes	No	0	9	9
65	R:R:D69	R:R:N300	8.08	Yes	Yes	0	9	9
66	R:R:L72	R:R:V76	4.47	No	Yes	0	7	7
67	R:R:L106	R:R:L72	6.92	No	No	0	6	7
68	R:R:G73	R:R:M77	5.24	No	Yes	0	7	7
69	R:R:H99	R:R:V76	8.3	No	Yes	0	5	7
70	R:R:D103	R:R:V76	11.69	No	Yes	1	6	7
71	R:R:V76	R:R:Y294	3.79	Yes	Yes	1	7	7
72	R:R:M77	R:R:W291	4.65	Yes	Yes	1	7	4
73	R:R:M77	R:R:Y294	16.76	Yes	Yes	1	7	7
74	R:R:F91	R:R:Y79	4.13	Yes	No	4	6	5
75	R:R:F95	R:R:Y79	8.25	Yes	No	4	5	5
76	R:R:H99	R:R:Y79	8.71	No	No	0	5	5
77	R:R:R83	R:R:S80	6.59	No	No	0	4	6
78	R:R:S80	R:R:W291	8.65	No	Yes	1	6	4
79	R:R:S80	R:R:Y294	8.9	No	Yes	1	6	7
80	R:R:V82	R:R:Y90	3.79	No	No	0	5	1
81	R:R:F91	R:R:V82	7.87	Yes	No	0	6	5
82	R:R:R83	R:R:W89	7	No	Yes	0	4	7
83	R:R:D287	R:R:S84	7.36	No	No	1	3	5
84	R:R:S84	R:R:W291	6.18	No	Yes	1	5	4
85	R:R:E86	R:R:Y90	19.08	No	No	0	4	1
86	R:R:F91	R:R:W89	12.03	Yes	Yes	4	6	7
87	R:R:F95	R:R:W89	4.01	Yes	Yes	4	5	7
88	R:R:C96	R:R:W89	11.75	No	Yes	4	9	7
89	R:R:H99	R:R:W89	9.52	No	Yes	0	5	7
90	R:R:C182	R:R:W89	9.14	No	Yes	4	9	7
91	R:R:F91	R:R:F95	8.57	Yes	Yes	4	6	5
92	R:R:C182	R:R:C96	7.28	No	No	4	9	9
93	R:R:F160	R:R:K97	3.72	Yes	No	0	4	6
94	R:R:F160	R:R:I98	5.02	Yes	No	0	4	4
95	R:R:F156	R:R:S101	9.25	Yes	No	3	4	6
96	R:R:I159	R:R:S101	6.19	No	No	3	6	6
97	R:R:F160	R:R:S101	6.61	Yes	No	3	4	6
98	R:R:D103	R:R:Y294	11.49	No	Yes	1	6	7
99	R:R:F156	R:R:M105	3.73	Yes	No	0	4	5
100	R:R:S107	R:R:W264	4.94	No	Yes	1	6	8
101	R:R:P151	R:R:S108	3.56	Yes	No	0	8	5
102	R:R:S108	R:R:S198	6.52	No	No	0	5	6
103	R:R:A109	R:R:P151	3.74	No	Yes	0	7	8
104	R:R:F260	R:R:I111	3.77	Yes	No	1	9	8
105	R:R:I111	R:R:W264	11.74	No	Yes	1	8	8
106	R:R:F112	R:R:S147	3.96	Yes	No	0	6	7
107	R:R:F112	R:R:V150	3.93	Yes	No	8	6	4
108	R:R:F112	R:R:P151	7.22	Yes	Yes	8	6	8
109	R:R:F112	R:R:P202	5.78	Yes	No	0	6	9
110	R:R:H113	R:R:S147	15.34	Yes	No	0	8	7
111	R:R:H113	R:R:W148	5.29	Yes	Yes	2	8	9
112	R:R:L114	R:R:M206	4.24	Yes	No	1	9	9
113	R:R:F260	R:R:L114	3.65	Yes	Yes	1	9	9
114	R:R:L114	R:R:N300	8.24	Yes	Yes	0	9	9
115	R:R:L114	R:R:Y304	8.21	Yes	Yes	1	9	9
116	R:R:P202	R:R:S115	3.56	No	No	0	9	7
117	R:R:F116	R:R:M143	17.42	No	No	0	7	6
118	R:R:F116	R:R:I146	5.02	No	No	0	7	3
119	R:R:I117	R:R:R121	6.26	No	No	1	9	9
120	R:R:I117	R:R:Y304	7.25	No	Yes	1	9	9
121	R:R:M206	R:R:S118	9.2	No	No	0	9	8
122	R:R:S118	R:R:Y210	8.9	No	Yes	0	8	9
123	R:R:D120	R:R:Y131	9.2	Yes	Yes	6	9	7
124	R:R:D120	R:R:M135	5.54	Yes	Yes	6	9	7
125	R:R:R121	R:R:Y304	4.12	No	Yes	1	9	9
126	R:R:R121	R:R:Y308	11.32	No	No	0	9	8
127	R:R:Y122	R:R:Y123	3.97	Yes	No	0	8	4
128	R:R:C126	R:R:Y122	12.1	No	Yes	0	6	8
129	R:R:V209	R:R:Y122	7.57	No	Yes	0	7	8
130	R:R:R212	R:R:Y122	11.32	No	Yes	0	5	8
131	R:R:M135	R:R:Y123	7.18	Yes	No	0	7	4
132	R:R:A124	R:R:Y131	9.34	No	Yes	0	8	7
133	R:R:D127	R:R:R130	10.72	No	No	0	5	5
134	R:R:D127	R:R:K134	4.15	No	No	0	5	4
135	R:R:M135	R:R:Y131	5.99	Yes	Yes	6	7	7
136	R:R:M135	R:R:V139	4.56	Yes	No	0	7	5
137	R:R:L138	R:R:N136	4.12	No	No	0	4	8
138	R:R:N136	R:R:V139	4.43	No	No	0	8	5
139	R:R:M143	R:R:V139	4.56	No	No	0	6	5
140	R:R:F145	R:R:S149	11.89	No	No	0	5	4
141	R:R:P151	R:R:V150	3.53	Yes	No	8	8	4
142	R:R:F154	R:R:M158	6.22	Yes	No	0	4	5
143	R:R:F154	R:R:L193	6.09	Yes	No	0	4	3
144	R:R:F154	R:R:T194	5.19	Yes	No	0	4	5
145	R:R:F154	R:R:T197	12.97	Yes	No	0	4	4
146	R:R:F156	R:R:F160	4.29	Yes	Yes	3	4	4
147	R:R:L163	R:R:M158	5.65	No	No	0	6	5
148	R:R:F186	R:R:M158	3.73	Yes	No	0	1	5
149	R:R:F160	R:R:I159	3.77	Yes	No	3	4	6
150	R:R:I159	R:R:N164	4.25	No	No	3	6	4
151	R:R:E162	R:R:N164	13.15	No	No	3	5	4
152	R:R:E162	R:R:F165	5.83	No	Yes	3	5	4
153	R:R:K166	R:R:L163	7.05	No	No	0	3	6
154	R:R:F165	R:R:N164	12.08	Yes	No	3	4	4
155	R:R:F165	R:R:Y172	41.26	Yes	Yes	3	4	3
156	R:R:F165	R:R:F185	5.36	Yes	No	3	4	1
157	R:R:Y172	R:R:Y173	3.97	Yes	No	0	3	2
158	R:R:V176	R:R:Y172	18.93	No	Yes	0	3	3
159	R:R:F185	R:R:Y172	18.57	No	Yes	3	1	3
160	R:R:H177	R:R:Y173	7.62	No	No	0	4	2
161	R:R:H175	R:R:V176	5.54	Yes	No	0	3	3
162	R:R:H175	R:R:S183	8.37	Yes	No	0	3	4
163	R:R:F185	R:R:H175	18.1	No	Yes	0	1	3
164	R:R:H175	R:R:Y279	18.51	Yes	No	0	3	1
165	R:R:H177	R:R:V176	4.15	No	No	0	4	3
166	R:R:F186	R:R:V184	3.93	Yes	No	0	1	4
167	R:R:F186	R:R:S190	5.28	Yes	No	0	1	6
168	R:R:F186	R:R:G191	4.52	Yes	No	0	1	4
169	R:R:F186	R:R:T194	14.27	Yes	No	1	1	5
170	R:R:S187	R:R:S190	6.52	No	No	0	4	6
171	R:R:F276	R:R:K188	11.17	No	No	0	5	3
172	R:R:F195	R:R:F199	8.57	Yes	Yes	1	5	8
173	R:R:F195	R:R:Y200	6.19	Yes	No	0	5	5
174	R:R:F195	R:R:F268	9.65	Yes	Yes	1	5	7
175	R:R:F195	R:R:V272	6.55	Yes	No	0	5	6
176	R:R:M196	R:R:Y200	9.58	No	No	0	5	5
177	R:R:F268	R:R:S198	6.61	Yes	No	0	7	6
178	R:R:F199	R:R:F260	7.5	Yes	Yes	1	8	9
179	R:R:F199	R:R:W264	4.01	Yes	Yes	1	8	8
180	R:R:C265	R:R:F199	6.98	No	Yes	0	6	8
181	R:R:F199	R:R:F268	18.22	Yes	Yes	1	8	7
182	R:R:I201	R:R:Y200	3.63	No	No	0	6	5
183	R:R:F260	R:R:M206	14.93	Yes	No	1	9	9
184	R:R:L207	R:R:M257	4.24	No	No	0	5	8
185	R:R:L253	R:R:Y210	7.03	No	Yes	0	7	9
186	R:R:V256	R:R:Y210	12.62	No	Yes	0	8	9
187	R:R:M257	R:R:Y210	3.59	No	Yes	0	8	9
188	R:R:L215	R:R:Y211	11.72	No	No	0	4	3
189	R:R:V250	R:R:Y214	5.05	No	No	0	8	5
190	R:R:E219	R:R:Q220	3.82	No	No	5	3	6
191	R:R:L223	R:R:R222	7.29	No	No	5	4	4
192	R:R:D226	R:R:R222	4.76	Yes	No	5	4	4
193	R:R:D226	R:R:L223	4.07	Yes	No	5	4	4
194	R:R:D226	R:R:K230	11.06	Yes	No	0	4	3
195	R:R:K230	R:R:Q229	9.49	No	No	0	3	3
196	R:R:I255	R:R:K251	4.36	No	No	0	6	6
197	R:R:L253	R:R:T252	4.42	No	Yes	0	7	9
198	R:R:F307	R:R:T252	5.19	No	Yes	0	7	9
199	R:R:F307	R:R:I255	3.77	No	No	0	7	6
200	R:R:V256	R:R:Y304	3.79	No	Yes	0	8	9
201	R:R:L261	R:R:M257	4.24	No	No	0	6	8
202	R:R:V259	R:R:V303	4.81	No	No	0	6	8
203	R:R:F260	R:R:L261	3.65	Yes	No	0	9	6
204	R:R:F260	R:R:W264	6.01	Yes	Yes	1	9	8
205	R:R:C263	R:R:N296	4.72	No	No	0	8	9
206	R:R:F267	R:R:W264	4.01	Yes	Yes	1	5	8
207	R:R:F268	R:R:W264	8.02	Yes	Yes	1	7	8
208	R:R:G293	R:R:W264	8.44	No	Yes	0	7	8
209	R:R:N296	R:R:W264	10.17	No	Yes	0	9	8
210	R:R:F267	R:R:F268	6.43	Yes	Yes	1	5	7
211	R:R:F267	R:R:T271	7.78	Yes	No	0	5	5
212	R:R:F267	R:R:L289	6.09	Yes	No	0	5	5
213	R:R:C270	R:R:L289	4.76	No	No	0	4	5
214	R:R:L277	R:R:M273	4.24	No	No	0	3	4
215	R:R:D274	R:R:I281	12.59	No	Yes	0	2	2
216	R:R:I281	R:R:L285	5.71	Yes	No	0	2	4
217	R:R:I281	R:R:N286	8.5	Yes	No	0	2	4
218	R:R:P282	R:R:T284	3.5	No	No	0	1	3
219	R:R:L285	R:R:P282	4.93	No	No	0	4	1
220	R:R:D287	R:R:W291	4.47	No	Yes	1	3	4
221	R:R:F292	R:R:V288	5.24	No	No	0	7	4
222	R:R:I290	R:R:W291	3.52	No	Yes	1	5	4
223	R:R:I290	R:R:Y294	6.04	No	Yes	1	5	7
224	R:R:W291	R:R:Y294	13.5	Yes	Yes	1	4	7
225	R:R:L295	R:R:T298	4.42	Yes	No	0	5	7
226	R:R:F299	R:R:L295	3.65	No	Yes	0	6	5
227	R:R:N296	R:R:N300	9.54	No	Yes	0	9	9
228	R:R:F299	R:R:M302	6.22	No	No	0	6	6
229	R:R:F306	R:R:M302	3.73	No	No	0	6	6
230	R:R:V303	R:R:Y304	5.05	No	Yes	0	8	9
231	R:R:A305	R:R:F311	8.32	No	Yes	0	7	9
232	R:R:F306	R:R:F311	6.43	No	Yes	0	6	9
233	R:R:W310	R:R:Y308	9.65	Yes	No	0	6	8
234	R:R:P309	R:R:R312	4.32	No	No	0	5	8
235	R:R:F311	R:R:W310	9.02	Yes	Yes	0	9	6
236	R:R:L315	R:R:L319	6.92	No	No	0	7	7
237	R:R:K316	R:R:M317	4.32	No	No	0	5	5
238	R:R:L54	R:R:W310	3.42	No	Yes	0	8	6
239	R:R:A66	R:R:V44	3.39	No	No	0	9	9
240	R:R:A305	R:R:V44	3.39	No	No	0	7	9
241	R:R:M105	R:R:P151	3.35	No	Yes	0	5	8
242	R:R:K188	R:R:P275	3.35	No	No	0	3	4
243	R:R:A155	R:R:I104	3.25	No	No	0	6	4
244	R:R:A152	R:R:M105	3.22	No	No	0	3	5
245	R:R:D127	R:R:P128	3.22	No	No	0	5	8
246	R:R:C74	R:R:L38	3.17	No	No	0	4	6
247	R:R:T102	R:R:V76	3.17	No	Yes	0	4	7
248	R:R:T100	R:R:V184	3.17	No	No	0	4	4
249	R:R:T298	R:R:T36	3.14	No	No	0	7	5
250	R:R:I205	R:R:S115	3.1	No	No	0	6	7
251	R:R:I213	R:R:V125	3.07	No	No	0	9	8
252	R:R:I216	R:R:V125	3.07	No	No	0	5	8
253	R:R:I146	R:R:V142	3.07	No	No	0	3	3
254	R:R:F260	R:R:G203	3.01	Yes	No	0	9	6
255	R:R:L71	R:R:T67	2.95	No	Yes	0	7	6
256	R:R:I119	R:R:I205	2.94	No	No	0	6	6
257	R:R:I34	R:R:L38	2.85	Yes	No	0	6	6
258	R:R:C208	R:R:R212	2.79	No	No	0	4	5
259	R:R:A314	R:R:F51	2.77	No	Yes	0	7	5
260	R:R:L71	R:R:L75	2.77	No	No	0	7	5
261	R:R:L285	R:R:L289	2.77	No	No	0	4	5
262	R:R:R247	R:R:V250	2.62	No	No	0	5	8
263	R:R:F51	R:R:M318	2.49	Yes	No	0	5	6
264	R:R:F292	R:R:L295	2.44	No	Yes	0	7	5
265	R:R:I62	R:R:W310	2.35	No	Yes	0	8	6
266	R:R:L215	R:R:Y214	2.34	No	No	0	4	5
267	R:R:E219	R:R:R222	2.33	No	No	5	3	4
268	R:R:H87	R:R:R23	2.26	No	No	0	4	4
269	R:R:G180	R:R:G181	2.11	No	No	0	4	3
270	R:R:P282	R:R:P283	1.95	No	No	0	1	1
271	R:R:C265	R:R:P266	1.88	No	No	0	6	9
272	R:R:G40	R:R:V39	1.84	No	No	0	9	5
273	R:R:A217	R:R:A249	1.79	No	No	0	8	8
274	R:R:G167	R:R:K166	1.74	No	No	0	4	3
275	R:R:C126	R:R:V125	1.71	No	No	0	6	8
276	R:R:A24	R:R:V22	1.7	No	No	0	4	3
277	R:R:A249	R:R:T252	1.68	No	Yes	0	8	9
278	R:R:C141	R:R:I137	1.64	No	No	0	1	2
279	R:R:C265	R:R:I269	1.64	No	No	0	6	6
280	R:R:C270	R:R:I269	1.64	No	No	0	4	6
281	R:R:S25	R:R:V22	1.62	No	No	0	4	3
282	R:R:S47	R:R:V46	1.62	No	No	0	8	4
283	R:R:S49	R:R:V46	1.62	No	No	0	3	4
284	R:R:S149	R:R:V150	1.62	No	No	0	4	4
285	R:R:A85	R:R:M30	1.61	No	Yes	0	5	6
286	R:R:D274	R:R:P275	1.61	No	No	0	2	4
287	R:R:I201	R:R:S204	1.55	No	No	0	6	4
288	R:R:I205	R:R:S204	1.55	No	No	0	6	4
289	R:R:I98	R:R:V94	1.54	No	No	0	4	1
290	R:R:A227	R:R:D226	1.54	No	Yes	0	4	4
291	R:R:F91	R:R:G92	1.51	Yes	No	4	6	8
292	R:R:F95	R:R:G92	1.51	Yes	No	4	5	8
293	R:R:F156	R:R:G157	1.51	Yes	No	0	4	6
294	R:R:G180	R:R:R179	1.5	No	No	0	4	2
295	R:R:K248	R:R:T252	1.5	No	Yes	0	8	9
296	R:R:L32	R:R:V31	1.49	No	No	0	5	5
297	R:R:L35	R:R:V31	1.49	No	No	0	5	5
298	R:R:I280	R:R:I281	1.47	No	Yes	0	1	2
299	R:R:I43	R:R:L315	1.43	No	No	0	7	7
300	R:R:I280	R:R:L277	1.43	No	No	0	1	3
301	R:R:I224	R:R:N228	1.42	No	No	0	5	4
302	R:R:L26	R:R:M30	1.41	No	Yes	0	5	6
303	R:R:G181	R:R:W89	1.41	No	Yes	0	3	7
304	R:R:P309	R:R:Y308	1.39	No	No	0	5	8
305	R:R:E170	R:R:I171	1.37	No	No	0	3	2
306	R:R:E219	R:R:I216	1.37	No	No	5	3	5
307	R:R:I216	R:R:Q220	1.37	No	No	5	5	6
308	R:R:K52	R:R:Q53	1.36	No	No	0	6	5
309	R:R:E93	R:R:K97	1.35	No	No	0	2	6
310	R:R:C88	R:R:Y90	1.34	No	No	0	4	1
311	R:R:F276	R:R:V192	1.31	No	No	0	5	5
312	R:R:S28	R:R:Y27	1.27	No	No	0	5	6
313	R:R:L253	R:R:Y214	1.17	No	No	0	7	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	11.018	10	1	0
2	R:R:M30	6.746	5	1	6
3	R:R:I34	3.955	4	1	6
4	R:R:F51	5.232	5	7	5
5	R:R:H63	7.0525	4	2	6
6	R:R:T67	4.1175	4	2	6
7	R:R:D69	8.3625	4	0	9
8	R:R:V76	6.284	5	1	7
9	R:R:M77	7.755	4	1	7
10	R:R:W89	7.83714	7	4	7
11	R:R:F91	6.822	5	4	6
12	R:R:F95	5.585	4	4	5
13	R:R:F112	5.2225	4	8	6
14	R:R:H113	9.042	5	2	8
15	R:R:L114	6.085	4	1	9
16	R:R:D120	7.2325	4	6	9
17	R:R:Y122	8.74	4	0	8
18	R:R:Y131	7.07	4	6	7
19	R:R:M135	5.8175	4	6	7
20	R:R:W148	5.92	4	2	9
21	R:R:P151	4.28	5	8	8
22	R:R:F154	7.6175	4	0	4
23	R:R:F156	4.695	4	3	4
24	R:R:F160	4.682	5	3	4
25	R:R:F165	16.1325	4	3	4
26	R:R:Y172	20.6825	4	3	3
27	R:R:H175	12.63	4	0	3
28	R:R:F186	6.36667	6	1	1
29	R:R:F195	7.74	4	1	5
30	R:R:F199	9.056	5	1	8
31	R:R:Y210	8.035	4	0	9
32	R:R:D226	5.3575	4	5	4
33	R:R:T252	3.1975	4	0	9
34	R:R:F260	6.07429	7	1	9
35	R:R:W264	7.42778	9	1	8
36	R:R:F267	8.928	5	1	5
37	R:R:F268	9.07833	6	1	7
38	R:R:I281	7.0675	4	0	2
39	R:R:W291	7.66556	9	1	4
40	R:R:Y294	10.0371	7	1	7
41	R:R:L295	4.4125	4	0	5
42	R:R:N300	7.8675	4	0	9
43	R:R:Y304	5.535	6	1	9
44	R:R:W310	6.244	5	0	6
45	R:R:F311	7.925	4	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:I290	30.6409	14.08	Yes	No	1	0	5
2	R:R:I290	R:R:W291	29.8575	3.52	No	Yes	1	5	4
3	R:R:M30	R:R:W291	27.3047	17.45	Yes	Yes	1	6	4
4	R:R:M30	R:R:M81	18.5115	8.66	Yes	No	0	6	6
5	R:R:M81	R:R:Y27	15.4589	5.99	No	No	0	6	6
6	L:L:?1	R:R:Y294	92.0848	9.78	Yes	Yes	1	0	7
7	R:R:W291	R:R:Y294	33.4774	13.5	Yes	Yes	1	4	7
8	R:R:I33	R:R:W291	40.258	7.05	No	Yes	0	7	4
9	R:R:I33	R:R:L295	38.5021	7.14	No	Yes	0	7	5
10	R:R:I34	R:R:W291	18.3899	3.52	Yes	Yes	1	6	4
11	R:R:M77	R:R:Y294	10.0561	16.76	Yes	Yes	1	7	7
12	L:L:?1	R:R:W264	79.7123	9.51	Yes	Yes	1	0	8
13	R:R:N296	R:R:W264	26.6496	10.17	No	Yes	0	9	8
14	R:R:N296	R:R:N300	26.0147	9.54	No	Yes	0	9	9
15	R:R:D69	R:R:N300	28.9998	8.08	Yes	Yes	0	9	9
16	R:R:D69	R:R:N41	15.3576	12.12	Yes	No	0	9	9
17	R:R:L295	R:R:T298	11.2379	4.42	Yes	No	0	5	7
18	R:R:T298	R:R:T37	11.8863	9.42	No	No	0	7	7
19	R:R:I34	R:R:L38	17.1203	2.85	Yes	No	0	6	6
20	R:R:F299	R:R:L295	29.5063	3.65	No	Yes	0	6	5
21	R:R:F299	R:R:M302	27.9395	6.22	No	No	0	6	6
22	R:R:F306	R:R:M302	26.8454	3.73	No	No	0	6	6
23	R:R:M65	R:R:N300	34.9294	5.61	No	Yes	0	9	9
24	R:R:H113	R:R:M65	56.9528	7.88	Yes	No	0	8	9
25	R:R:H113	R:R:W148	16.5192	5.29	Yes	Yes	2	8	9
26	R:R:T67	R:R:W148	34.7133	4.85	Yes	Yes	2	6	9
27	R:R:H63	R:R:T67	27.6693	4.11	Yes	Yes	2	6	6
28	R:R:F260	R:R:W264	72.0538	6.01	Yes	Yes	1	9	8
29	R:R:F260	R:R:L114	41.8586	3.65	Yes	Yes	1	9	9
30	R:R:L114	R:R:Y304	46.5591	8.21	Yes	Yes	1	9	9
31	R:R:R121	R:R:Y304	63.2876	4.12	No	Yes	1	9	9
32	R:R:R121	R:R:Y308	62.0585	11.32	No	No	0	9	8
33	R:R:W310	R:R:Y308	57.4053	9.65	Yes	No	0	6	8
34	R:R:F311	R:R:W310	38.0766	9.02	Yes	Yes	0	9	6
35	R:R:F306	R:R:F311	29.1889	6.43	No	Yes	0	6	9
36	R:R:N59	R:R:W310	56.6556	6.78	No	Yes	0	9	6
37	R:R:I48	R:R:N59	25.542	4.25	No	No	0	7	9
38	R:R:H63	R:R:I48	23.131	6.63	Yes	No	2	6	7
39	R:R:L54	R:R:W310	17.1135	3.42	No	Yes	0	8	6
40	R:R:N59	R:R:T56	61.7546	8.77	No	No	0	9	8
41	R:R:P57	R:R:T56	60.2148	3.5	No	No	0	6	8
42	R:R:I140	R:R:P57	55.5143	6.77	No	No	0	7	6
43	R:R:I140	R:R:L61	53.9204	7.14	No	No	0	7	7
44	R:R:D120	R:R:L61	39.738	4.07	Yes	No	0	9	7
45	R:R:L61	R:R:M143	12.771	4.24	No	No	0	7	6
46	L:L:?1	R:R:F268	63.9562	5.54	Yes	Yes	1	0	7
47	R:R:F268	R:R:S198	66.9346	6.61	Yes	No	0	7	6
48	R:R:S108	R:R:S198	64.9017	6.52	No	No	0	5	6
49	R:R:P151	R:R:S108	63.8279	3.56	Yes	No	0	8	5
50	R:R:A109	R:R:P151	37.6038	3.74	No	Yes	0	7	8
51	R:R:H113	R:R:V68	18.3427	5.54	Yes	No	2	8	8
52	R:R:A109	R:R:V68	37.0771	5.09	No	No	0	7	8
53	L:L:?1	R:R:D103	35.7061	13.39	Yes	No	1	0	6
54	R:R:D103	R:R:V76	34.3891	11.69	No	Yes	1	6	7
55	R:R:V76	R:R:Y294	38.7114	3.79	Yes	Yes	1	7	7
56	R:R:H99	R:R:V76	59.1882	8.3	No	Yes	0	5	7
57	R:R:H99	R:R:Y79	22.6717	8.71	No	No	0	5	5
58	R:R:F91	R:R:Y79	14.2703	4.13	Yes	No	4	6	5
59	R:R:H99	R:R:W89	33.0789	9.52	No	Yes	0	5	7
60	R:R:F91	R:R:W89	25.4137	12.03	Yes	Yes	4	6	7
61	R:R:S80	R:R:Y294	18.8019	8.9	No	Yes	1	6	7
62	R:R:R83	R:R:S80	27.3047	6.59	No	No	0	4	6
63	R:R:R83	R:R:W89	25.6028	7	No	Yes	0	4	7
64	R:R:F91	R:R:V82	26.4672	7.87	Yes	No	0	6	5
65	R:R:V82	R:R:Y90	19.869	3.79	No	No	0	5	1
66	R:R:M105	R:R:P151	100	3.35	No	Yes	0	5	8
67	R:R:F156	R:R:M105	94.8943	3.73	Yes	No	0	4	5
68	R:R:F156	R:R:F160	50.5639	4.29	Yes	Yes	3	4	4
69	R:R:F156	R:R:S101	39.326	9.25	Yes	No	3	4	6
70	R:R:I159	R:R:S101	36.6043	6.19	No	No	3	6	6
71	R:R:F160	R:R:I159	36.9555	3.77	Yes	No	3	4	6
72	R:R:F112	R:R:P151	22.8473	7.22	Yes	Yes	8	6	8
73	R:R:H113	R:R:S147	24.9342	15.34	Yes	No	0	8	7
74	R:R:F112	R:R:S147	24.3061	3.96	Yes	No	0	6	7
75	R:R:F260	R:R:M206	21.4628	14.93	Yes	No	1	9	9
76	R:R:F195	R:R:F268	13.5949	9.65	Yes	Yes	1	5	7
77	R:R:F195	R:R:Y200	15.0604	6.19	Yes	No	0	5	5
78	R:R:M206	R:R:S118	22.8135	9.2	No	No	0	9	8
79	R:R:S118	R:R:Y210	20.774	8.9	No	Yes	0	8	9
80	R:R:F260	R:R:L261	24.3466	3.65	Yes	No	0	9	6
81	R:R:L261	R:R:M257	21.7735	4.24	No	No	0	6	8
82	R:R:M257	R:R:Y210	19.3017	3.59	No	Yes	0	8	9
83	R:R:D120	R:R:M135	32.7345	5.54	Yes	Yes	6	9	7
84	R:R:M135	R:R:Y123	32.1267	7.18	Yes	No	0	7	4
85	R:R:Y122	R:R:Y123	30.337	3.97	Yes	No	0	8	4
86	R:R:C126	R:R:Y122	23.0432	12.1	No	Yes	0	6	8
87	L:L:?1	R:R:F186	24.8666	6.47	Yes	Yes	1	0	1
88	R:R:F186	R:R:M158	10.2857	3.73	Yes	No	0	1	5
89	R:R:I159	R:R:N164	67.9881	4.25	No	No	3	6	4
90	R:R:F165	R:R:N164	56.7232	12.08	Yes	No	3	4	4
91	R:R:F165	R:R:Y172	28.4257	41.26	Yes	Yes	3	4	3
92	R:R:F165	R:R:F185	22.7392	5.36	Yes	No	3	4	1
93	R:R:Y172	R:R:Y173	11.4405	3.97	Yes	No	0	3	2
94	R:R:V176	R:R:Y172	11.4405	18.93	No	Yes	0	3	3
95	R:R:F185	R:R:H175	17.127	18.1	No	Yes	0	1	3
96	L:L:?1	R:R:F267	20.5916	20.33	Yes	Yes	1	0	5
97	R:R:F267	R:R:L289	39.0559	6.09	Yes	No	0	5	5
98	R:R:L285	R:R:L289	33.7476	2.77	No	No	0	4	5
99	R:R:I281	R:R:L285	24.3736	5.71	Yes	No	0	2	4
100	R:R:D274	R:R:I281	12.3523	12.59	No	Yes	0	2	2
101	R:R:C265	R:R:F199	11.7782	6.98	No	Yes	0	6	8
102	R:R:L253	R:R:Y210	54.1298	7.03	No	Yes	0	7	9
103	R:R:V256	R:R:Y304	24.3398	3.79	No	Yes	0	8	9
104	R:R:L253	R:R:Y214	21.1657	1.17	No	No	0	7	5
105	R:R:C126	R:R:V125	21.1859	1.71	No	No	0	6	8
106	R:R:I216	R:R:V125	17.4242	3.07	No	No	0	5	8
107	R:R:E219	R:R:I216	13.703	1.37	No	No	5	3	5
108	R:R:E219	R:R:R222	11.8255	2.33	No	No	5	3	4
109	R:R:L253	R:R:T252	29.3307	4.42	No	Yes	0	7	9
110	R:R:F307	R:R:T252	12.5211	5.19	No	Yes	0	7	9
111	R:R:G181	R:R:W89	12.8385	1.41	No	Yes	0	3	7
112	R:R:F267	R:R:W264	15.8168	4.01	Yes	Yes	1	5	8
113	R:R:V68	R:R:W148	19.5583	7.36	No	Yes	2	8	9
114	R:R:F199	R:R:F260	14.3986	7.5	Yes	Yes	1	8	9
115	R:R:S80	R:R:W291	10.0898	8.65	No	Yes	1	6	4
116	R:R:M65	R:R:Y304	36.5435	4.79	No	Yes	0	9	9
117	R:R:L114	R:R:N300	12.5144	8.24	Yes	Yes	0	9	9
118	R:R:V256	R:R:Y210	21.868	12.62	No	Yes	0	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D103	13.39	1	Yes	No	0	6	0	1
L:L:?1	R:R:I104	14.08	1	Yes	No	0	4	0	1
L:L:?1	R:R:S107	12.53	1	Yes	No	0	6	0	1
L:L:?1	R:R:F186	6.47	1	Yes	Yes	0	1	0	1
L:L:?1	R:R:T194	4.47	1	Yes	No	0	5	0	1
L:L:?1	R:R:W264	9.51	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F267	20.33	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:F268	5.54	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:I290	14.08	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y294	9.78	1	Yes	Yes	0	7	0	1
R:R:D103	R:R:V76	11.69	1	No	Yes	6	7	1	2
R:R:V76	R:R:Y294	3.79	1	Yes	Yes	7	7	2	1
R:R:M77	R:R:W291	4.65	1	Yes	Yes	7	4	2	2
R:R:M77	R:R:Y294	16.76	1	Yes	Yes	7	7	2	1
R:R:S80	R:R:W291	8.65	1	No	Yes	6	4	2	2
R:R:S80	R:R:Y294	8.9	1	No	Yes	6	7	2	1
R:R:D103	R:R:Y294	11.49	1	No	Yes	6	7	1	1
R:R:S107	R:R:W264	4.94	1	No	Yes	6	8	1	1
R:R:F260	R:R:I111	3.77	1	Yes	No	9	8	2	2
R:R:I111	R:R:W264	11.74	1	No	Yes	8	8	2	1
R:R:F154	R:R:M158	6.22	0	Yes	No	4	5	2	2
R:R:F154	R:R:T194	5.19	0	Yes	No	4	5	2	1
R:R:F186	R:R:M158	3.73	1	Yes	No	1	5	1	2
R:R:F186	R:R:V184	3.93	1	Yes	No	1	4	1	2
R:R:F186	R:R:S190	5.28	1	Yes	No	1	6	1	2
R:R:F186	R:R:G191	4.52	1	Yes	No	1	4	1	2
R:R:F186	R:R:T194	14.27	1	Yes	No	1	5	1	1
R:R:F195	R:R:F199	8.57	1	Yes	Yes	5	8	2	2
R:R:F195	R:R:F268	9.65	1	Yes	Yes	5	7	2	1
R:R:F268	R:R:S198	6.61	1	Yes	No	7	6	1	2
R:R:F199	R:R:F260	7.5	1	Yes	Yes	8	9	2	2
R:R:F199	R:R:W264	4.01	1	Yes	Yes	8	8	2	1
R:R:F199	R:R:F268	18.22	1	Yes	Yes	8	7	2	1
R:R:F260	R:R:W264	6.01	1	Yes	Yes	9	8	2	1
R:R:F267	R:R:W264	4.01	1	Yes	Yes	5	8	1	1
R:R:F268	R:R:W264	8.02	1	Yes	Yes	7	8	1	1
R:R:G293	R:R:W264	8.44	0	No	Yes	7	8	2	1
R:R:N296	R:R:W264	10.17	0	No	Yes	9	8	2	1
R:R:F267	R:R:F268	6.43	1	Yes	Yes	5	7	1	1
R:R:F267	R:R:T271	7.78	1	Yes	No	5	5	1	2
R:R:F267	R:R:L289	6.09	1	Yes	No	5	5	1	2
R:R:I290	R:R:W291	3.52	1	No	Yes	5	4	1	2
R:R:I290	R:R:Y294	6.04	1	No	Yes	5	7	1	1
R:R:W291	R:R:Y294	13.5	1	Yes	Yes	4	7	2	1
R:R:A155	R:R:I104	3.25	0	No	No	6	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8ZSS_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.5
Number of Linked Nodes	264
Number of Links	313
Number of Hubs	45
Number of Links mediated by Hubs	183
Number of Communities	8
Number of Nodes involved in Communities	68
Number of Links involved in Communities	98

Path Summary
Number Of Nodes in MetaPath	119
Number Of Links MetaPath	118
Number of Shortest Paths	58631
Length Of Smallest Path	3
Average Path Length	12.5801
Length of Longest Path	33
Minimum Path Strength	1.45
Average Path Strength	6.95483
Maximum Path Strength	30.095
Minimum Path Correlation	0.7
Average Path Correlation	0.930845
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	53.6213
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.0857
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • G protein-coupled amine receptor activity • molecular transducer activity • trace-amine receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • electron transport chain • metabolic process • generation of precursor metabolites and energy • phospholipase C-activating G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • periplasmic space • endomembrane system • organelle subcompartment • endoplasmic reticulum subcompartment • nuclear outer membrane-endoplasmic reticulum membrane network • endoplasmic reticulum • endoplasmic reticulum membrane • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • signaling receptor binding • G protein-coupled receptor binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • D1 dopamine receptor binding • dopamine receptor binding • G protein activity • molecular function regulator activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • positive regulation of cell population proliferation • positive regulation of biological process • positive regulation of neural precursor cell proliferation • regulation of cell population proliferation • neural precursor cell proliferation • positive regulation of cellular process • regulation of neural precursor cell proliferation • reactive oxygen species metabolic process • regulation of superoxide metabolic process • positive regulation of reactive oxygen species metabolic process • superoxide metabolic process • positive regulation of metabolic process • superoxide anion generation • positive regulation of superoxide anion generation • regulation of superoxide anion generation • regulation of metabolic process • regulation of reactive oxygen species metabolic process • regulation of calcium ion transport • regulation of localization • transport • regulation of transport • regulation of monoatomic ion transport • establishment of localization • metal ion transport • calcium ion transport • localization • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • negative regulation of signaling • negative regulation of biological process • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • adenylate cyclase-activating adrenergic receptor signaling pathway • negative regulation of response to stimulus • negative regulation of signal transduction • negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell division • regulation of body fluid levels • multicellular organismal process • renal system process • system process • positive regulation of urine volume • regulation of urine volume • regulation of biological quality • regulation of vascular associated smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell proliferation • regulation of smooth muscle cell proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • muscle cell proliferation • vascular associated smooth muscle cell proliferation • cell-cell signaling • gamma-aminobutyric acid signaling pathway • purinergic nucleotide receptor signaling pathway • cell surface receptor signaling pathway • G protein-coupled purinergic receptor signaling pathway • G protein-coupled adenosine receptor signaling pathway • regulation of molecular function • regulation of adenylate cyclase activity • regulation of catalytic activity • negative regulation of molecular function • negative regulation of catalytic activity • negative regulation of adenylate cyclase activity • regulated exocytosis • regulation of calcium ion-dependent exocytosis • negative regulation of transport • negative regulation of regulated secretory pathway • vesicle-mediated transport • regulation of regulated secretory pathway • secretion by cell • regulation of secretion by cell • negative regulation of secretion • negative regulation of exocytosis • negative regulation of secretion by cell • calcium-ion regulated exocytosis • secretion • negative regulation of calcium ion-dependent exocytosis • export from cell • regulation of vesicle-mediated transport • regulation of secretion • exocytosis • regulation of exocytosis • regulation of programmed cell death • negative regulation of apoptotic signaling pathway • negative regulation of programmed cell death • regulation of apoptotic process • cell death • apoptotic signaling pathway • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of apoptotic signaling pathway • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • locomotion • trans-synaptic signaling • modulation of chemical synaptic transmission • negative regulation of synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • response to nutrient levels • response to nutrient • developmental process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • cellular homeostasis • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • intracellular chemical homeostasis • intracellular glucose homeostasis • nervous system process • neuromuscular process • regulation of system process • skeletal muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • striated muscle contraction • multicellular organismal movement • musculoskeletal movement • regulation of striated muscle contraction • regulation of muscle contraction • regulation of skeletal muscle contraction • regulation of multicellular organismal process • sensory perception of chemical stimulus • sensory perception • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • multicellular organism development • skeletal system development • bone development • system development • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • intracellular protein localization • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • regulation of protein secretion • cellular response to carbohydrate stimulus • response to glucose • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • signal release • cellular response to hexose stimulus • cellular response to monosaccharide stimulus • positive regulation of peptide secretion • regulation of peptide transport • regulation of establishment of protein localization • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • peptide transport • response to hexose • positive regulation of transport • regulation of cellular localization • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • regulation of insulin secretion involved in cellular response to glucose stimulus • hormone transport • insulin secretion • serotonin receptor signaling pathway • adenylate cyclase-activating serotonin receptor signaling pathway • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • positive regulation of catalytic activity • positive regulation of lyase activity • bile acid signaling pathway • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • midbody • dense core granule • intracellular vesicle • cytoplasmic vesicle • secretory granule • secretory vesicle • neuronal dense core vesicle • centrosome • microtubule organizing center • cytoskeleton • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • somatodendritic compartment • dendrite • dendritic tree • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • neuron to neuron synapse • hippocampal mossy fiber to CA3 synapse • cell body • ciliary basal body • Golgi apparatus subcompartment • Golgi apparatus • trans-Golgi network membrane • trans-Golgi network
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q96RJ0
Sequence	>8ZSS_nogp_Chain_R V R A S L Y S L M V L I I L T T L V G N L I V I V S I S H F K Q L H T P T N W L I H S M A T V D F L L G C L V M P Y S M V R S A E H C W Y F G E V F C K I H T S T D I M L S S A S I F H L S F I S I D R Y Y A V C D P L R Y K A K M N I L V I C V M I F I S W S V P A V F A F G M I F L E L N F K G A E E I Y Y K H V H C R G G C S V F F S K I S G V L T F M T S F Y I P G S I M L C V Y Y R I Y L I A K E Q A R L I S D A N Q K R K A V K T L G I V M G V F L I C W C P F F I C T V M D P F L H Y I I P P T L N D V L I W F G Y L N S T F N P M V Y A F F Y P W F R K A L K M M L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8JLJ	A	Amine	Trace Amine	TA1	Mus musculus	T1AM	-	chim(NtGi1-Gs)/β1/γ2	3.1	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLJ (No Gprot)	A	Amine	Trace Amine	TA1	Mus musculus	T1AM	-		3.1	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLK	A	Amine	Trace Amine	TA1	Mus musculus	Ulotaront	-	chim(NtGi1-Gs)/β1/γ2	3.22	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLK (No Gprot)	A	Amine	Trace Amine	TA1	Mus musculus	Ulotaront	-		3.22	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLN	A	Amine	Trace Amine	TA1	Homo sapiens	T1AM	-	Gs/β1/γ2	3.24	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLN (No Gprot)	A	Amine	Trace Amine	TA1	Homo sapiens	T1AM	-		3.24	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLO	A	Amine	Trace Amine	TA1	Homo sapiens	Ulotaront	-	Gs/β1/γ2	3.52	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLO (No Gprot)	A	Amine	Trace Amine	TA1	Homo sapiens	Ulotaront	-		3.52	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLP	A	Amine	Trace Amine	TA1	Homo sapiens	Ralmitaront	-	Gs/β1/γ2	3.23	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLP (No Gprot)	A	Amine	Trace Amine	TA1	Homo sapiens	Ralmitaront	-		3.23	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLQ	A	Amine	Trace Amine	TA1	Homo sapiens	Fenoldopam	-	Gs/β1/γ2	2.84	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLQ (No Gprot)	A	Amine	Trace Amine	TA1	Homo sapiens	Fenoldopam	-		2.84	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLR	A	Amine	Trace Amine	TA1	Homo sapiens	A77636	-	chim(NtGi1-Gs)/β1/γ2	3	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JLR (No Gprot)	A	Amine	Trace Amine	TA1	Homo sapiens	A77636	-		3	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JSO	A	Amine	Trace Amine	TA1	Homo sapiens	AMPH	-	chim(NtGi1-Gs)/β1/γ2	3.4	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8JSO (No Gprot)	A	Amine	Trace Amine	TA1	Homo sapiens	AMPH	-		3.4	2023-11-15	doi.org/10.1038/s41586-023-06804-z
	8W87	A	Amine	Trace Amine	TA1	Homo sapiens	METH	-	chim(NtGi1L-Gs)/β1/γ2	2.8	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W87 (No Gprot)	A	Amine	Trace Amine	TA1	Homo sapiens	METH	-		2.8	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W88	A	Amine	Trace Amine	TA1	Homo sapiens	SEP-363856	-	Gs/β1/γ2	2.6	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W88 (No Gprot)	A	Amine	Trace Amine	TA1	Homo sapiens	SEP-363856	-		2.6	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W89	A	Amine	Trace Amine	TA1	Homo sapiens	2-Phenylethylamine	-	chim(NtGi1L-Gs)/β1/γ2	3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W89 (No Gprot)	A	Amine	Trace Amine	TA1	Homo sapiens	2-Phenylethylamine	-		3	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W8A	A	Amine	Trace Amine	TA1	Homo sapiens	RO5256390	-	chim(NtGi1L-Gs)/β1/γ2	2.8	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8W8A (No Gprot)	A	Amine	Trace Amine	TA1	Homo sapiens	RO5256390	-		2.8	2023-11-22	doi.org/10.1038/s41586-023-06775-1
	8ZSJ	A	Amine	Trace Amine	TA1	Homo sapiens	-	-	chim(NtGi1L-Gs)/β1/γ2	2.8	2024-07-24	doi.org/10.1016/j.celrep.2024.114505
	8ZSJ (No Gprot)	A	Amine	Trace Amine	TA1	Homo sapiens	-	-		2.8	2024-07-24	doi.org/10.1016/j.celrep.2024.114505
	8ZSP	A	Amine	Trace Amine	TA1	Homo sapiens	LSD	-	chim(NtGi1L-Gs)/β1/γ2	3.14	2024-07-24	doi.org/10.1016/j.celrep.2024.114505
	8ZSP (No Gprot)	A	Amine	Trace Amine	TA1	Homo sapiens	LSD	-		3.14	2024-07-24	doi.org/10.1016/j.celrep.2024.114505
	8ZSS	A	Amine	Trace Amine	TA1	Homo sapiens	RO5263397	-	chim(NtGi1-Gs)/β1/γ2	3.07	2024-07-24	doi.org/10.1016/j.celrep.2024.114505
	8ZSS (No Gprot)	A	Amine	Trace Amine	TA1	Homo sapiens	RO5263397	-		3.07	2024-07-24	doi.org/10.1016/j.celrep.2024.114505
	8ZSV	A	Amine	Trace Amine	TA1	Mus musculus	RO5263397	-	chim(NtGi1-Gs)/β1/γ2	2.96	2024-07-24	doi.org/10.1016/j.celrep.2024.114505
	8ZSV (No Gprot)	A	Amine	Trace Amine	TA1	Mus musculus	RO5263397	-		2.96	2024-07-24	doi.org/10.1016/j.celrep.2024.114505
	8WC3	A	Amine	Trace Amine	TA1	Mus musculus	SEP-363856	-	chim(NtGi1-Gs)/β1/γ2	3	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC3 (No Gprot)	A	Amine	Trace Amine	TA1	Mus musculus	SEP-363856	-		3	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC4	A	Amine	Trace Amine	TA1	Mus musculus	ZH8651	-	chim(NtGi1-Gs)/β1/γ2	3.1	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC4 (No Gprot)	A	Amine	Trace Amine	TA1	Mus musculus	ZH8651	-		3.1	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC5	A	Amine	Trace Amine	TA1	Mus musculus	Tetramethylammonium Ion	-	chim(NtGi1-Gs)/β1/γ2	3.3	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC5 (No Gprot)	A	Amine	Trace Amine	TA1	Mus musculus	Tetramethylammonium Ion	-		3.3	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC6	A	Amine	Trace Amine	TA1	Mus musculus	2-Phenylethylamine	-	chim(NtGi1-Gs)/β1/γ2	3.2	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC6 (No Gprot)	A	Amine	Trace Amine	TA1	Mus musculus	2-Phenylethylamine	-		3.2	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC7	A	Amine	Trace Amine	TA1	Mus musculus	ZH8667	-	chim(NtGi1-Gs)/β1/γ2	3.1	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC7 (No Gprot)	A	Amine	Trace Amine	TA1	Mus musculus	ZH8667	-		3.1	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC8	A	Amine	Trace Amine	TA1	Homo sapiens	ZH8651	-	chim(NtGi1-Gs)/β1/γ2	2.9	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC8 (No Gprot)	A	Amine	Trace Amine	TA1	Homo sapiens	ZH8651	-		2.9	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC9	A	Amine	Trace Amine	TA1	Mus musculus	ZH8651	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.2	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WC9 (No Gprot)	A	Amine	Trace Amine	TA1	Mus musculus	ZH8651	-		3.2	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WCA	A	Amine	Trace Amine	TA1	Homo sapiens	2-Phenylethylamine	-	chim(NtGi1-Gs)/β1/γ2	3.48	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WCA (No Gprot)	A	Amine	Trace Amine	TA1	Homo sapiens	2-Phenylethylamine	-		3.48	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WCB	A	Amine	Trace Amine	TA1	Mus musculus	Cyclohexylammonium Ion	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.1	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WCB (No Gprot)	A	Amine	Trace Amine	TA1	Mus musculus	Cyclohexylammonium Ion	-		3.1	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8WCC	A	Amine	Trace Amine	TA1	Mus musculus	Cyclohexylammonium Ion	-	-	3.04	2023-12-27	doi.org/10.1016/j.cell.2023.10.014
	8UHB	A	Amine	Trace Amine	TA1	Homo sapiens	RO5256390	-	Gs/β1/γ2	3.35	2024-01-10	doi.org/10.1038/s41467-023-44601-4
	8UHB (No Gprot)	A	Amine	Trace Amine	TA1	Homo sapiens	RO5256390	-		3.35	2024-01-10	doi.org/10.1038/s41467-023-44601-4
	9JKQ	A	Amine	Trace Amine	TA1	Homo sapiens	METH	-	Gs/β1/γ2	2.66	2024-10-16	doi.org/10.1021/acs.jmedchem.4c01961
	9JKQ (No Gprot)	A	Amine	Trace Amine	TA1	Homo sapiens	METH	-		2.66	2024-10-16	doi.org/10.1021/acs.jmedchem.4c01961

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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We apologize for the inconvenience.