Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:N40 5.5125409
2R:R:V43 2.8475409
3R:R:I44 4.495437
4R:R:V67 3.946508
5R:R:D68 5.682509
6R:R:I75 4.88406
7R:R:M76 4.45407
8R:R:M80 8.596516
9R:R:T83 3.8025414
10R:R:W88 5.556547
11R:R:H112 9.2425408
12R:R:F159 3.625405
13R:R:Y171 14.652523
14R:R:Q174 6.5575422
15R:R:P201 2.885408
16R:R:F257 3.8475409
17R:R:W261 6.54857717
18R:R:F264 9.5375416
19R:R:F265 8.92616
20R:R:W288 8.084515
21R:R:Y291 5.94167617
22R:R:Y305 5.1075408
23R:R:W307 5.9825406
24L:L:?1 9.421821110
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:W288 R:R:Y291 17.68278.68YesYes157
2L:L:?1 R:R:Y291 22.46248.33YesYes107
3L:L:?1 R:R:S106 52.99513.55YesNo006
4R:R:S106 R:R:W261 56.3293.71NoYes067
5R:R:N293 R:R:W261 1007.91NoYes097
6R:R:N293 R:R:N297 95.19628.17NoNo099
7R:R:D68 R:R:N297 74.36714.04YesNo099
8R:R:D68 R:R:N40 60.15766.73YesYes099
9L:L:?1 R:R:F265 59.033514.42YesYes106
10R:R:F265 R:R:W261 67.15667.02YesYes167
11R:R:F69 R:R:N40 50.94396.04NoYes079
12R:R:I47 R:R:V43 29.61523.07NoYes089
13R:R:A65 R:R:V43 36.9653.39NoYes099
14R:R:A65 R:R:I44 38.40613.25NoYes097
15R:R:F69 R:R:I44 49.58932.51NoYes077
16R:R:I47 R:R:S46 26.58883.1NoNo088
17R:R:F308 R:R:W307 20.57456.01NoYes086
18R:R:F308 R:R:S46 25.04687.93NoNo088
19R:R:I116 R:R:L60 16.33762.85NoNo098
20R:R:I116 R:R:Y301 17.8466.04NoNo099
21R:R:L113 R:R:Y301 23.79795.86NoNo089
22R:R:L113 R:R:N297 25.3118.24NoNo089
23R:R:W307 R:R:Y305 14.2727.72YesYes068
24R:R:D68 R:R:V67 16.74112.92YesYes098
25R:R:D102 R:R:I75 81.8377NoYes066
26R:R:I75 R:R:T101 75.96683.04YesNo064
27R:R:M104 R:R:T101 74.74186.02NoNo054
28R:R:F155 R:R:M104 72.25346.22NoNo045
29R:R:F155 R:R:S100 60.73413.21NoNo045
30R:R:I158 R:R:S100 59.39387.74NoNo055
31R:R:I158 R:R:N163 44.28117.08NoNo054
32R:R:L164 R:R:N163 42.82565.49NoNo034
33R:R:L164 R:R:Y171 35.403814.07NoYes033
34R:R:C181 R:R:Y171 14.95414.03NoYes293
35R:R:C181 R:R:C95 13.44573.64NoNo099
36R:R:C95 R:R:W88 11.7983.92NoYes097
37R:R:F155 R:R:F159 13.33533.22NoYes045
38R:R:I158 R:R:T99 16.35684.56NoNo054
39R:R:P183 R:R:T99 14.73323.5NoNo044
40L:L:?1 R:R:S107 10.08314.74YesNo105
41R:R:P150 R:R:S107 11.74043.56NoNo075
42R:R:F257 R:R:M205 41.36526.22YesNo098
43R:R:F257 R:R:W261 49.6954.01YesYes097
44R:R:M205 R:R:S117 39.94333.07NoNo088
45R:R:S117 R:R:Y209 37.07075.09NoNo089
46R:R:V208 R:R:Y121 19.41688.83NoNo068
47R:R:I212 R:R:V208 20.97323.07NoNo096
48R:R:I212 R:R:L250 29.8412.85NoNo097
49R:R:L250 R:R:Y209 34.15965.86NoNo079
50R:R:F184 R:R:Y171 15.064641.26NoYes223
51R:R:F185 R:R:P183 11.68285.78NoNo024
52R:R:F273 R:R:K187 12.16797.44NoNo063
53R:R:F273 R:R:V191 13.86852.62NoNo065
54R:R:V191 R:R:V269 18.91241.6NoNo055
55R:R:F194 R:R:V269 22.2276.55NoNo055
56R:R:F194 R:R:F265 15.46333.22NoYes156
57R:R:K187 R:R:P272 10.45783.35NoNo033
58R:R:R211 R:R:Y121 14.68032.06NoNo048
59R:R:R211 R:R:Y210 11.48588.23NoNo043
60L:L:?1 R:R:D102 77.465517.14YesNo106
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:L71 R:R:S106 3 0 No No 7 6 2 1
R:R:D102 R:R:I75 7 1 No Yes 6 6 1 2
R:R:M76 R:R:Y291 3.59 0 Yes Yes 7 7 2 1
R:R:S79 R:R:Y291 7.63 0 No Yes 6 7 2 1
R:R:D102 R:R:Y291 3.45 1 No Yes 6 7 1 1
L:L:?1 R:R:D102 17.14 1 Yes No 0 6 0 1
R:R:A154 R:R:I103 3.25 0 No No 7 4 2 1
L:L:?1 R:R:I103 7.88 1 Yes No 0 4 0 1
R:R:S106 R:R:W261 3.71 0 No Yes 6 7 1 2
L:L:?1 R:R:S106 3.55 1 Yes No 0 6 0 1
R:R:P150 R:R:S107 3.56 0 No No 7 5 2 1
R:R:S107 R:R:S197 4.89 1 No No 5 5 1 1
L:L:?1 R:R:S107 4.74 1 Yes No 0 5 0 1
R:R:M157 R:R:Y153 4.79 0 No No 5 4 2 1
L:L:?1 R:R:Y153 4.63 1 Yes No 0 4 0 1
R:R:F194 R:R:F198 8.57 1 No No 5 7 2 2
R:R:F194 R:R:F265 3.22 1 No Yes 5 6 2 1
R:R:F265 R:R:S197 5.28 1 Yes No 6 5 1 1
L:L:?1 R:R:S197 8.29 1 Yes No 0 5 0 1
R:R:F198 R:R:W261 3.01 1 No Yes 7 7 2 2
R:R:F198 R:R:F265 16.08 1 No Yes 7 6 2 1
R:R:F265 R:R:W261 7.02 1 Yes Yes 6 7 1 2
R:R:F264 R:R:F265 7.5 1 Yes Yes 6 6 1 1
R:R:F264 R:R:T268 7.78 1 Yes No 6 4 1 2
R:R:F264 R:R:L286 3.65 1 Yes No 6 5 1 2
L:L:?1 R:R:F264 19.22 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F265 14.42 1 Yes Yes 0 6 0 1
R:R:N283 R:R:Y287 4.65 0 No No 2 5 2 1
R:R:Y287 R:R:Y291 3.97 1 No Yes 5 7 1 1
L:L:?1 R:R:Y287 12.95 1 Yes No 0 5 0 1
R:R:W288 R:R:Y291 8.68 1 Yes Yes 5 7 2 1
L:L:?1 R:R:Y291 8.33 1 Yes Yes 0 7 0 1
L:L:?1 R:R:A193 2.49 1 Yes No 0 4 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8WC7_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.85
Number of Linked Nodes 247
Number of Links 260
Number of Hubs 24
Number of Links mediated by Hubs 101
Number of Communities 5
Number of Nodes involved in Communities 30
Number of Links involved in Communities 40
Path Summary
Number Of Nodes in MetaPath 61
Number Of Links MetaPath 60
Number of Shortest Paths 41088
Length Of Smallest Path 3
Average Path Length 15.1269
Length of Longest Path 35
Minimum Path Strength 1.405
Average Path Strength 6.17724
Maximum Path Strength 27.665
Minimum Path Correlation 0.7
Average Path Correlation 0.930118
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.44828
Average % Of Corr. Nodes 48.7908
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 31.8496
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• D2 dopamine receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • molecular function regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • catalytic activity   • adenylate cyclase activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • D1 dopamine receptor binding   • molecular function activator activity   • enzyme activator activity   • cyclase activator activity   • adenylate cyclase activator activity   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • protein localization   • positive regulation of protein localization to cell periphery   • regulation of localization   • protein localization to cell periphery   • cellular localization   • regulation of protein localization   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • localization   • regulation of cellular localization   • regulation of protein localization to cell cortex   • cellular macromolecule localization   • macromolecule localization   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • cellular response to nitrogen compound   • cellular response to peptide hormone stimulus   • response to glucagon   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • homeostatic process   • adaptive thermogenesis   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • establishment of protein localization   • nitrogen compound transport   • regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • regulation of hormone secretion   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle
Gene OntologyCellular Component• midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle   • nuclear lumen   • cell periphery   • cell cortex   • cytoplasm   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • endomembrane system   • cilium   • plasma membrane bounded cell projection   • ciliary basal body   • cell projection   • Golgi apparatus subcompartment   • organelle subcompartment   • trans-Golgi network membrane   • trans-Golgi network   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • synapse   • cell junction   • G protein-coupled amine receptor activity   • molecular transducer activity   • trace-amine receptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • endoplasmic reticulum subcompartment   • nuclear outer membrane-endoplasmic reticulum membrane network   • endoplasmic reticulum   • endoplasmic reticulum membrane   • G-protein beta-subunit binding   • fibroblast proliferation
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeVMK
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeVMK
Name2-[4-(3-fluorophenyl)phenyl]ethanamine
Synonyms
Identifier
FormulaC14 H14 F N
Molecular Weight215.266
SMILES
PubChem39243566
Formal Charge0
Total Atoms30
Total Chiral Atoms0
Total Bonds31
Total Aromatic Bonds12

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ923Y8
Sequence
>8WC7_nogp_Chain_R
LYSLMSLII LATLVGNLI VIISISHFK QLHTPTNWL LHSMAIVDF 
LLGCLIMPC SMVRTVERC WYFGEILCK VHTSTDIML SSASIFHLA 
FISIDRYCA VCDPLRYKA KINISTILV MILVSWSLP AVYAFGMIF 
LELNLKGVE ELYRSQVSD LGGCSPFFS KVSGVLAFM TSFYIPGSV 
MLFVYYRIY FIAKGQARS INRTTKAAK TLGIMVGVF LVCWCPFFL 
CTVLDPFLG YVIPPSLND ALYWFGYLN SALNPMVYA FFYPWFRRA


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9JKQAAmineTrace Amine ReceptorsTA1Homo sapiensMETH-Gs/β1/γ22.662024-10-16doi.org/10.1021/acs.jmedchem.4c01961
9JKQ (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensMETH-2.662024-10-16doi.org/10.1021/acs.jmedchem.4c01961
8ZSVAAmineTrace Amine ReceptorsTA1Mus musculusRO5263397-chim(NtGi1-Gs)/β1/γ22.962024-07-2410.1016/j.celrep.2024.114505
8ZSV (No Gprot) AAmineTrace Amine ReceptorsTA1Mus musculusRO5263397-2.962024-07-2410.1016/j.celrep.2024.114505
8ZSSAAmineTrace Amine ReceptorsTA1Homo sapiensRO5263397-chim(NtGi1-Gs)/β1/γ23.072024-07-2410.1016/j.celrep.2024.114505
8ZSS (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensRO5263397-3.072024-07-2410.1016/j.celrep.2024.114505
8ZSPAAmineTrace Amine ReceptorsTA1Homo sapiensLSD-chim(NtGi1L-Gs-CtGq)/β1/γ23.142024-07-2410.1016/j.celrep.2024.114505
8ZSP (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensLSD-3.142024-07-2410.1016/j.celrep.2024.114505
8ZSJAAmineTrace Amine ReceptorsTA1Homo sapiens--chim(NtGi1L-Gs-CtGq)/β1/γ22.82024-07-2410.1016/j.celrep.2024.114505
8ZSJ (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiens--2.82024-07-2410.1016/j.celrep.2024.114505
8UHBAAmineTrace Amine ReceptorsTA1Homo sapiensRO5256390-Gs/β1/γ23.352024-01-1010.1038/s41467-023-44601-4
8UHB (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensRO5256390-3.352024-01-1010.1038/s41467-023-44601-4
8WCCAAmineTrace Amine ReceptorsTA1Mus musculusCyclohexylammonium Ion--3.042023-12-2710.1016/j.cell.2023.10.014
8WCBAAmineTrace Amine ReceptorsTA1Mus musculusCyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ23.12023-12-2710.1016/j.cell.2023.10.014
8WCB (No Gprot) AAmineTrace Amine ReceptorsTA1Mus musculusCyclohexylammonium Ion-3.12023-12-2710.1016/j.cell.2023.10.014
8WC9AAmineTrace Amine ReceptorsTA1Mus musculusZH8651-chim(NtGi1-Gs-CtGq)/β1/γ23.22023-12-2710.1016/j.cell.2023.10.014
8WC9 (No Gprot) AAmineTrace Amine ReceptorsTA1Mus musculusZH8651-3.22023-12-2710.1016/j.cell.2023.10.014
8WCAAAmineTrace Amine ReceptorsTA1Homo sapiens2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ23.482023-12-2710.1016/j.cell.2023.10.014
8WCA (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiens2-Phenylethylamine-3.482023-12-2710.1016/j.cell.2023.10.014
8WC8AAmineTrace Amine ReceptorsTA1Homo sapiensZH8651-chim(NtGi1-Gs)/β1/γ22.92023-12-2710.1016/j.cell.2023.10.014
8WC8 (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensZH8651-2.92023-12-2710.1016/j.cell.2023.10.014
8WC7AAmineTrace Amine ReceptorsTA1Mus musculusZH8667-chim(NtGi1-Gs)/β1/γ23.12023-12-2710.1016/j.cell.2023.10.014
8WC7 (No Gprot) AAmineTrace Amine ReceptorsTA1Mus musculusZH8667-3.12023-12-2710.1016/j.cell.2023.10.014
8WC6AAmineTrace Amine ReceptorsTA1Mus musculus2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ23.22023-12-2710.1016/j.cell.2023.10.014
8WC6 (No Gprot) AAmineTrace Amine ReceptorsTA1Mus musculus2-Phenylethylamine-3.22023-12-2710.1016/j.cell.2023.10.014
8WC5AAmineTrace Amine ReceptorsTA1Mus musculusTetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ23.32023-12-2710.1016/j.cell.2023.10.014
8WC5 (No Gprot) AAmineTrace Amine ReceptorsTA1Mus musculusTetramethylammonium Ion-3.32023-12-2710.1016/j.cell.2023.10.014
8WC4AAmineTrace Amine ReceptorsTA1Mus musculusZH8651-chim(NtGi1-Gs)/β1/γ23.12023-12-2710.1016/j.cell.2023.10.014
8WC4 (No Gprot) AAmineTrace Amine ReceptorsTA1Mus musculusZH8651-3.12023-12-2710.1016/j.cell.2023.10.014
8WC3AAmineTrace Amine ReceptorsTA1Mus musculusSEP-363856-chim(NtGi1-Gs)/β1/γ232023-12-2710.1016/j.cell.2023.10.014
8WC3 (No Gprot) AAmineTrace Amine ReceptorsTA1Mus musculusSEP-363856-32023-12-2710.1016/j.cell.2023.10.014
8W8AAAmineTrace Amine ReceptorsTA1Homo sapiensRO5256390-chim(NtGi1L-Gs)/β1/γ22.82023-11-2210.1038/s41586-023-06775-1
8W8A (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensRO5256390-2.82023-11-2210.1038/s41586-023-06775-1
8W89AAmineTrace Amine ReceptorsTA1Homo sapiensPEA-chim(NtGi1L-Gs)/β1/γ232023-11-2210.1038/s41586-023-06775-1
8W89 (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensPEA-32023-11-2210.1038/s41586-023-06775-1
8W87AAmineTrace Amine ReceptorsTA1Homo sapiensMETH-chim(NtGi1L-Gs)/β1/γ22.82023-11-2210.1038/s41586-023-06775-1
8W87 (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensMETH-2.82023-11-2210.1038/s41586-023-06775-1
8W88AAmineTrace Amine ReceptorsTA1Homo sapiensSEP-363856-Gs/β1/γ22.62023-11-2210.1038/s41586-023-06775-1
8W88 (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensSEP-363856-2.62023-11-2210.1038/s41586-023-06775-1
8JSOAAmineTrace Amine ReceptorsTA1Homo sapiensAMPH-chim(NtGi1-Gs)/β1/γ23.42023-11-1510.1038/s41586-023-06804-z
8JSO (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensAMPH-3.42023-11-1510.1038/s41586-023-06804-z
8JLRAAmineTrace Amine ReceptorsTA1Homo sapiensA77636-chim(NtGi1-Gs)/β1/γ232023-11-1510.1038/s41586-023-06804-z
8JLR (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensA77636-32023-11-1510.1038/s41586-023-06804-z
8JLKAAmineTrace Amine ReceptorsTA1Mus musculusUlotaront-chim(NtGi1-Gs)/β1/γ23.222023-11-1510.1038/s41586-023-06804-z
8JLK (No Gprot) AAmineTrace Amine ReceptorsTA1Mus musculusUlotaront-3.222023-11-1510.1038/s41586-023-06804-z
8JLJAAmineTrace Amine ReceptorsTA1Mus musculusT1AM-chim(NtGi1-Gs)/β1/γ23.12023-11-1510.1038/s41586-023-06804-z
8JLJ (No Gprot) AAmineTrace Amine ReceptorsTA1Mus musculusT1AM-3.12023-11-1510.1038/s41586-023-06804-z
8JLQAAmineTrace Amine ReceptorsTA1Homo sapiensFenoldopam-Gs/β1/γ22.842023-11-1510.1038/s41586-023-06804-z
8JLQ (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensFenoldopam-2.842023-11-1510.1038/s41586-023-06804-z
8JLPAAmineTrace Amine ReceptorsTA1Homo sapiensRalmitaront-Gs/β1/γ23.232023-11-1510.1038/s41586-023-06804-z
8JLP (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensRalmitaront-3.232023-11-1510.1038/s41586-023-06804-z
8JLOAAmineTrace Amine ReceptorsTA1Homo sapiensUlotaront-Gs/β1/γ23.522023-11-1510.1038/s41586-023-06804-z
8JLO (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensUlotaront-3.522023-11-1510.1038/s41586-023-06804-z
8JLNAAmineTrace Amine ReceptorsTA1Homo sapiensT1AM-Gs/β1/γ23.242023-11-1510.1038/s41586-023-06804-z
8JLN (No Gprot) AAmineTrace Amine ReceptorsTA1Homo sapiensT1AM-3.242023-11-1510.1038/s41586-023-06804-z




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