Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:M40 4.875416
2R:R:F61 4.42506
3R:R:R63 3.7275406
4R:R:F71 4.5125408
5R:R:V86 4.85417
6R:R:V87 3.226517
7R:R:W99 9.57667617
8R:R:F101 8.406515
9R:R:W105 8.94415
10R:R:W109 5.02515
11R:R:R131 4.43409
12R:R:W158 5.56409
13R:R:S161 2.415408
14R:R:Y174 6.538525
15R:R:R175 17.975422
16R:R:H178 4.6175422
17R:R:F194 5.41421
18R:R:Y199 6.018506
19R:R:F208 12.755408
20R:R:P211 9.5975448
21R:R:Y219 5.79857709
22R:R:E225 6.5825405
23R:R:H269 7.225405
24R:R:F282 6.72509
25R:R:F289 8.495416
26R:R:I303 3.3225403
27R:R:L311 2.51405
28R:R:W313 7.56515
29R:R:Y316 8.77516
30R:R:N318 5.9275409
31R:R:N322 5.255439
32R:R:Y326 5.898539
33R:R:F332 5.45833609
34L:L:?1 9.0261010
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:D79 R:R:N322 15.40044.04NoYes099
2R:R:N318 R:R:N322 55.99454.09YesYes099
3R:R:F282 R:R:N318 62.35067.25YesYes099
4R:R:F282 R:R:W286 99.399810.02YesNo098
5R:R:V117 R:R:W286 99.81024.9NoNo068
6L:L:?1 R:R:V117 1004.56YesNo006
7L:L:?1 R:R:D113 51.680119.72YesNo107
8R:R:D113 R:R:Y316 14.89778.05NoYes176
9R:R:W313 R:R:Y316 22.24915.43YesYes156
10L:L:?1 R:R:N312 15.831312.6YesNo105
11R:R:N312 R:R:Y316 18.878612.79NoYes156
12R:R:D79 R:R:N51 11.3228.08NoNo099
13R:R:F332 R:R:F336 11.15797.5YesNo097
14R:R:F332 R:R:Y326 33.64284.13YesYes099
15R:R:N322 R:R:Y326 38.78325.81YesYes399
16R:R:F61 R:R:L64 12.54814.87YesNo068
17R:R:F332 R:R:L64 13.91277.31YesNo098
18R:R:F282 R:R:L124 62.18646.09YesNo098
19R:R:L124 R:R:M279 60.44224.24NoNo088
20R:R:M279 R:R:Y219 57.718210.78NoYes089
21R:R:L272 R:R:Y219 19.83794.69NoYes079
22R:R:L272 R:R:R131 18.68883.64NoYes079
23R:R:D130 R:R:R131 15.05164.76NoYes089
24R:R:D130 R:R:S143 13.70248.83NoNo084
25R:R:S74 R:R:W158 12.49176.18NoYes099
26R:R:L115 R:R:W158 16.55475.69NoYes059
27R:R:L115 R:R:S165 17.58073NoNo057
28R:R:S165 R:R:V114 20.16626.46NoNo075
29L:L:?1 R:R:V114 21.43336.84YesNo005
30R:R:V86 R:R:W109 37.24933.68YesYes175
31R:R:W109 R:R:W99 16.85737.5YesYes157
32R:R:W105 R:R:W109 12.63024.69YesYes155
33R:R:F101 R:R:T100 14.9136.49YesNo052
34R:R:Y174 R:R:Y199 31.73455.96YesYes056
35R:R:S203 R:R:Y199 39.911812.72NoYes056
36L:L:?1 R:R:S203 40.7486.89YesNo005
37R:R:A128 R:R:Y219 14.05124NoYes089
38R:R:V222 R:R:Y219 24.2196.31NoYes089
39R:R:I135 R:R:V222 22.94163.07NoNo098
40R:R:E225 R:R:I135 21.65394.1YesNo059
41R:R:A128 R:R:V218 12.69173.39NoNo086
42R:R:E225 R:R:Q229 13.71266.37YesNo057
43R:R:K140 R:R:Q229 12.35329.49NoNo057
44R:R:K140 R:R:Y141 10.983415.53NoNo057
45R:R:Y174 R:R:Y185 24.33184.96YesNo251
46R:R:A181 R:R:Y185 23.34684NoNo241
47R:R:A181 R:R:F194 17.87315.55NoYes241
48L:L:?1 R:R:F290 13.471512.11YesNo007
49R:R:F208 R:R:F290 10.819333.22YesNo087
50R:R:F289 R:R:L311 17.70892.44YesYes065
51R:R:L311 R:R:V292 10.69614.47YesNo055
52R:R:M40 R:R:W313 13.384310.47YesYes165
53R:R:D113 R:R:V86 35.94625.84NoYes177
54L:L:?1 R:R:F289 16.48289.32YesYes106
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D113 R:R:V86 5.84 1 No Yes 7 7 1 2
R:R:V86 R:R:Y316 3.79 1 Yes Yes 7 6 2 2
R:R:F193 R:R:T110 5.19 0 No No 4 4 1 2
R:R:D113 R:R:Y316 8.05 1 No Yes 7 6 1 2
L:L:?1 R:R:D113 19.72 1 Yes No 0 7 0 1
R:R:S165 R:R:V114 6.46 0 No No 7 5 2 1
L:L:?1 R:R:V114 6.84 1 Yes No 0 5 0 1
R:R:V117 R:R:W286 4.9 0 No No 6 8 1 2
L:L:?1 R:R:V117 4.56 1 Yes No 0 6 0 1
R:R:S207 R:R:T118 9.59 0 No No 5 6 1 2
R:R:F193 R:R:T195 7.78 0 No No 4 3 1 2
L:L:?1 R:R:F193 8.38 1 Yes No 0 4 0 1
R:R:T195 R:R:Y199 3.75 0 No Yes 3 6 2 2
R:R:S203 R:R:Y199 12.72 0 No Yes 5 6 1 2
L:L:?1 R:R:S203 6.89 1 Yes No 0 5 0 1
R:R:F290 R:R:S204 3.96 0 No No 7 5 1 2
R:R:N293 R:R:S204 4.47 0 No No 5 5 1 2
L:L:?1 R:R:S207 4.59 1 Yes No 0 5 0 1
R:R:F208 R:R:F290 33.22 0 Yes No 8 7 2 1
R:R:F289 R:R:Y308 11.35 1 Yes No 6 5 1 2
R:R:F289 R:R:N312 10.87 1 Yes No 6 5 1 1
L:L:?1 R:R:F289 9.32 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F290 12.11 1 Yes No 0 7 0 1
L:L:?1 R:R:N293 5.25 1 Yes No 0 5 0 1
R:R:N312 R:R:Y316 12.79 1 No Yes 5 6 1 2
L:L:?1 R:R:N312 12.6 1 Yes No 0 5 0 1
R:R:F289 R:R:L311 2.44 1 Yes Yes 6 5 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Single8GGKEpinephrine8GGK-β2-Epinephrine
100.00Single8GGMEpinephrine8GGM-β2-Epinephrine
100.00Single8GGPEpinephrine8GGP-β2-Epinephrine
90.91Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
90.91Single6PS2(S)-Alprenolol6PS2-β2-(S)-Alprenolol
90.91Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
90.91Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
90.91Single8GE3Epinephrine8GE3-β2-Epinephrine-Gs/&β;1/&γ;2
90.91Single8GEEEpinephrine8GEE-β2-Epinephrine-Gs/&β;1/&γ;2
90.91Single8GFWEpinephrine8GFW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.91Single8GFXEpinephrine8GFX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.91Single8GFYEpinephrine8GFY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.91Single8GFZEpinephrine8GFZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.91Single8GG0Epinephrine8GG0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.91Single8GG1Epinephrine8GG1-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.91Single8GG2Epinephrine8GG2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.91Single8GG6Epinephrine8GG6-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.91Single8GGJEpinephrine8GGJ-β2-Epinephrine
90.91Single8GGNEpinephrine8GGN-β2-Epinephrine
90.91Single8GGOEpinephrine8GGO-β2-Epinephrine
90.91Single8GGUEpinephrine8GGU-β2-Epinephrine
90.91Single8UNNEpinephrine8UNN-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.91Single8UNPEpinephrine8UNP-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.91Consensusadrenergic_onOrthosteric Ligandbeta_on alpha_on
90.91Consensusdopamine_onOrthosteric Ligandd3_on d2_on d5_on d1_on
90.00Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2
90.00Single8GEDEpinephrine8GED-β2-Epinephrine-Gs/&β;1/&γ;2
90.00Single8GG7Epinephrine8GG7-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.00Single8UNLEpinephrine8UNL-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.00Single8UNOEpinephrine8UNO-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.00Single8UNTEpinephrine8UNT-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.00Single8UNUEpinephrine8UNU-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
90.00Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
83.33Single2RH1(S)-Carazolol2RH1-β2-(S)-Carazolol
83.33Single6E67BI1671076E67-β2-BI167107-Gs (fused)
83.33Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
83.33Single6PS3(S)-Carvedilol6PS3-β2-(S)-Carvedilol
83.33Single7BVQ(S)-Carazolol7BVQ-β1-(S)-Carazolol
83.33Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2
83.33Single7XKAEpinephrine7XKA-β2-Epinephrine
83.33Single8UNYEpinephrine8UNY-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
83.33Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
83.33Consensusamine_offOrthosteric Ligandadrenergic_off histamine_off muscarinic_off 5ht_off dopamine_off
83.33Consensusbeta2_offOrthosteric Ligand6PS2-β2-(S)-Alprenolol 6PS3-β2-(S)-Carvedilol 6PS5-β2-(S)-Propranolol 6PS6-β2-Timolol 2RH1-β2-(S)-Carazolol 6PS4-β2-ICI 118-551 3NY9-β2-PubChem 913103
83.33Consensusbeta2_onOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
83.33Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
83.33Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRR-D1-Rotigotine-Gs/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
83.33Consensusgi_adrenergicOrthosteric Ligand7S0F-β1-Isoprenaline-Gi1/&β;1/&γ;2 6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
81.82Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
81.82Single6PS4ICI 118-5516PS4-β2-ICI 118-551
81.82Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
81.82Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/&β;1/&γ;2
81.82Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
81.82Single8GDZEpinephrine8GDZ-β2-Epinephrine-Gs/&β;1/&γ;2
81.82Single8GE1Epinephrine8GE1-β2-Epinephrine-Gs/&β;1/&γ;2
81.82Single8GE4Epinephrine8GE4-β2-Epinephrine-Gs/&β;1/&γ;2
81.82Single8GE6Epinephrine8GE6-β2-Epinephrine-Gs/&β;1/&γ;2
81.82Single8GE7Epinephrine8GE7-β2-Epinephrine-Gs/&β;1/&γ;2
81.82Single8GE8Epinephrine8GE8-β2-Epinephrine-Gs/&β;1/&γ;2
81.82Single8GE9Epinephrine8GE9-β2-Epinephrine-Gs/&β;1/&γ;2
81.82Single8GEGEpinephrine8GEG-β2-Epinephrine-Gs/&β;1/&γ;2
81.82Single8GFVEpinephrine8GFV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8GG3Epinephrine8GG3-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8GG4Epinephrine8GG4-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8GG5Epinephrine8GG5-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8GGIEpinephrine8GGI-β2-Epinephrine
81.82Single8GGLEpinephrine8GGL-β2-Epinephrine
81.82Single8GGQEpinephrine8GGQ-β2-Epinephrine
81.82Single8UNQEpinephrine8UNQ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8UNREpinephrine8UNR-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8UNSEpinephrine8UNS-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Single8UNZEpinephrine8UNZ-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
81.82Consensusd3_onOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
80.00Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2
80.00Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/&β;1/&γ;2
80.00Single8GGSEpinephrine8GGS-β2-Epinephrine
80.00Single8UNVEpinephrine8UNV-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
80.00Consensus5ht4_onOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
76.92Single3P0GBI1671073P0G-β2-BI167107
76.92Single3SN6BI1671073SN6-β2-BI167107-Gs/&β;1/&γ;2
76.92Single5D5A(S)-Carazolol5D5A-β2-(S)-Carazolol
76.92Single5D5B(S)-Carazolol5D5B-β2-(S)-Carazolol
76.92Single6H7JIsoprenaline6H7J-β1-Isoprenaline
76.92Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
76.92Single6WGTLSD6WGT-5-HT2A-LSD
76.92Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2
76.92Single7JVPSKF839597JVP-D1-SKF83959-Gs/&β;1/&γ;2
76.92Single7W6PW967W6P-α2a-W96-Go/&β;1/&γ;2
76.92Single7W7EW587W7E-α2a-W58-Go/&β;1/&γ;2
76.92Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/&β;1/&γ;2
76.92Consensus5ht5_offOrthosteric Ligand5ht5a_off
76.92Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCZ-β1-Iodocyanopindolol
76.92Consensusgi_amineOrthosteric Ligandgi_5ht gi_adrenergic gi_dopamine gi_muscarinic gi_histamine
76.92Consensusgi_dopamineOrthosteric Ligand8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2 7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2 7CMV-D3-PD128907-Gi1/&β;1/&γ;2 7CMU-D3-Pramipexole-Gi1/&β;1/&γ;2
76.92Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/&β;1/&γ;2 7CKX-D1-A77636-Gs/&β;1/&γ;2 7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2 7CKY-D1-PW0464-Gs/&β;1/&γ;2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2 7JV5-D1-SKF81297-Gs/&β;1/&γ;2 7JVP-D1-SKF83959-Gs/&β;1/&γ;2 7X2D-D1-Tavapadon-Gs/&β;1/&γ;2 7JOZ-D1-VFP-Gs/&β;1/&γ;2
75.00Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
75.00Single2Y02Carmoterol2Y02-β1-Carmoterol
75.00Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
75.00Single3NY8ICI 118-5513NY8-β2-ICI 118-551
75.00Single3NYA(S)-Alprenolol3NYA-β2-(S)-Alprenolol
75.00Single4GBR(S)-Carazolol4GBR-β2-(S)-Carazolol
75.00Single5JQH(S)-Carazolol5JQH-β2-(S)-Carazolol
75.00Single6H7MSalbutamol6H7M-β1-Salbutamol
75.00Single6PRZ(S)-Alprenolol6PRZ-β2-(S)-Alprenolol
75.00Single6PS0(S)-Carazolol6PS0-β2-(S)-Carazolol
75.00Single6PS1Timolol6PS1-β2-Timolol
75.00Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
75.00Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/&β;1/&γ;2
75.00Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/&β;1/&γ;2
75.00Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2
75.00Single7WC7Lisuride7WC7-5-HT2A-Lisuride
75.00Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
75.00Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
75.00Single8GEBEpinephrine8GEB-β2-Epinephrine-Gs/&β;1/&γ;2
75.00Single8GEHEpinephrine8GEH-β2-Epinephrine-Gs/&β;1/&γ;2
75.00Single8GGBEpinephrine8GGB-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/&β;1/&γ;2
75.00Single8JJOAlprenolol8JJO-β2-Alprenolol
75.00Single8UNMEpinephrine8UNM-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
75.00Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2
75.00Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2
75.00Consensusalpha2_onOrthosteric Ligandalpha2a_on alpha2b_on
75.00Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
75.00Consensusamine_onOrthosteric Ligandadrenergic_on histamine_on muscarinic_on tar_on 5ht_on dopamine_on
75.00Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
75.00Consensusgi_5htOrthosteric Ligand7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2 8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E32-5-HT1D-Serotonin-Gi1/&β;1/&γ;2 7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2 7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2 7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2 7X5H-5-HT5A-5-CT-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
72.73Single6OBA(S)-Alprenolol6OBA-β2-(S)-Alprenolol-GTPL11074
72.73Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2
72.73Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/&β;1/&γ;2
72.73Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
72.73Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
72.73Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2
72.73Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2
72.73Single8GEAEpinephrine8GEA-β2-Epinephrine-Gs/&β;1/&γ;2
72.73Single8GECEpinephrine8GEC-β2-Epinephrine-Gs/&β;1/&γ;2
72.73Single8GEFEpinephrine8GEF-β2-Epinephrine-Gs/&β;1/&γ;2
72.73Single8GG9Epinephrine8GG9-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8GGAEpinephrine8GGA-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8GGVEpinephrine8GGV-β2-Epinephrine
72.73Single8GGWEpinephrine8GGW-β2-Epinephrine
72.73Single8GGXEpinephrine8GGX-β2-Epinephrine
72.73Single8GH0Epinephrine8GH0-β2-Epinephrine
72.73Single8UNWEpinephrine8UNW-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8UO0Epinephrine8UO0-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
72.73Single8UO1Epinephrine8UO1-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
72.73Consensusbeta2_off_alloOrthosteric Ligand6OBA-β2-(S)-Alprenolol-GTPL11074
72.73Consensusgs_5htOrthosteric Ligand7XT8-5-HT4-Serotonin-Gs/&β;1/&γ;2 7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2 7XTC-5-HT7-5-CT-Gs/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
71.43Single3D4STimolol Maleate3D4S-β2-Timolol Maleate
71.43Single4AMIBucindolol4AMI-β1-Bucindolol
71.43Single4LDEBI1671074LDE-β2-BI167107
71.43Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
71.43Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
71.43Single6MXTSalmeterol6MXT-β2-Salmeterol
71.43Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
71.43Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/&β;1/&γ;2
71.43Single8JJ8Formoterol8JJ8-β2-Formoterol
71.43Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_muscarinic gs_tar
70.00Single8GGREpinephrine8GGR-β2-Epinephrine
69.23Single2Y03Isoprenaline2Y03-β1-Isoprenaline
69.23Single2YCW(S)-Carazolol2YCW-β1-(S)-Carazolol
69.23Single5D6L(S)-Carazolol5D6L-β2-(S)-Carazolol
69.23Single5TVNLSD5TVN-5-HT2B-LSD
69.23Single5X7D(S)-Carazolol5X7D-β2-(S)-Carazolol-PubChem 129318963
69.23Single7CKXA776367CKX-D1-A77636-Gs/&β;1/&γ;2
69.23Single7WC6LSD7WC6-5-HT2A-LSD
69.23Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on 5ht1b_on
69.23Consensusadrenergic_offOrthosteric Ligandbeta_off alpha_off
69.23Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2
69.23Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
69.23Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2 8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
69.23Consensusgs_adrenergicOrthosteric Ligand3SN6-β2-BI167107-Gs/&β;1/&γ;2 7DHR-β2-Isoprenaline-Gs/&β;1/&γ;2 7DHI-β2-Salbutamol-Gs/&β;1/&γ;2 7XJH-β3-Isoproterenol-Gs/&β;1/&γ;2 7DH5-β3-Mirabegron-Gs/&β;1/&γ;2 7XJI-β3-Solabegron-Gs/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2 7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
69.23Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2 8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2 8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
66.67Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
66.67Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
66.67Single6A94Zotepine6A94-5-HT2A-Zotepine
66.67Single6H7LDobutamine6H7L-β1-Dobutamine
66.67Single6IBLArformoterol6IBL-β1-Arformoterol
66.67Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
66.67Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/&β;1/&γ;2
66.67Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
66.67Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
66.67Single7JOZVFP7JOZ-D1-VFP-Gs/&β;1/&γ;2
66.67Single7UM4AS26747237UM4-5-HT5A-AS2674723
66.67Single8GG8Epinephrine8GG8-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Single8GGTEpinephrine8GGT-β2-Epinephrine
66.67Single8JLNT1AM8JLN-TA1-T1AM-Gs/&β;1/&γ;2
66.67Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2
66.67Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
66.67Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
66.67Single8UO2Epinephrine8UO2-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
66.67Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/&β;1/&γ;2
66.67Consensus5ht5_onOrthosteric Ligand5ht5a_on
66.67Consensus5ht5a_offOrthosteric Ligand7UM4-5-HT5A-AS2674723
66.67Consensus5ht5a_onOrthosteric Ligand7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
66.67Consensusalpha2b_onOrthosteric Ligand6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2
66.67Consensusbeta1_off_alloOrthosteric Ligand4BVN-β1-Cyanopindolol-Na
66.67Consensusd1_on_alloOrthosteric Ligand7LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2 7CKZ-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;2
64.29Single2YDVNECA2YDV-A2A-NECA
64.29Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
64.29Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
64.29Single4UHRCGS216804UHR-A2A-CGS21680
64.29Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
64.29Single5G53NECA5G53-A2A-NECA-Gs
64.29Single6NI3BI1671076NI3-β2-BI167107-Gs/&β;1/&γ;2
64.29Single7JV5SKF812977JV5-D1-SKF81297-Gs/&β;1/&γ;2
64.29Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/&β;1/&γ;2
64.29Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/&β;1/&γ;2
64.29Consensus5ht_offOrthosteric Ligand5ht2_off 5ht5_off 5ht1_off
64.29Consensusdopamine_offOrthosteric Ligandd3_off d2_off d4_off
64.29Consensusgo_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 6K41-α2b-Dexmedetomidine-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
64.29Consensush1_offOrthosteric Ligand3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole 8X63-H1-Mepyramine 8X64-H1-Desloratadine
64.29Consensushistamine_offOrthosteric Ligandh1_off
64.29Consensusnk1_offOrthosteric Ligand6J20-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
63.64Single3PBLEticlopride3PBL-D3-Eticlopride
63.64Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
63.64Single7SRQLSD7SRQ-5-HT2B-LSD
63.64Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/&β;1/&γ;2
63.64Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/&β;1/&γ;2
63.64Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
63.64Single8EF6Morphine8EF6-μ-Morphine-Gi1/&β;1/&γ;2
63.64Single8GEIEpinephrine8GEI-β2-Epinephrine-Gs/&β;1/&γ;2
63.64Single8GGYEpinephrine8GGY-β2-Epinephrine
63.64Single8GH1Epinephrine8GH1-β2-Epinephrine
63.64Single8UNXEpinephrine8UNX-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
63.64Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
62.50Single3NY9PubChem 9131033NY9-β2-PubChem 913103
61.54Single2Y04Salbutamol2Y04-β1-Salbutamol
61.54Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
61.54Single4QKXPubChem 762106284QKX-β2-PubChem 76210628
61.54Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/&β;1/&γ;2
61.54Single7BU7BI1671077BU7-β1-BI167107
61.54Single7CRHSKF839597CRH-D1-SKF83959-Gs/&β;1/&γ;2
61.54Single7LJCPubChem 867641037LJC-D1-PubChem 86764103-Mevidalen-Gs/&β;1/&γ;2
61.54Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/&β;1/&γ;2
61.54Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2
61.54Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
61.54Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/&β;1/&γ;2
61.54Single8UO4Epinephrine8UO4-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
61.54Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/&β;1/&γ;2
61.54Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/&β;1/&γ;2
61.54Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/&β;1/&γ;2
61.54Single8X63Mepyramine8X63-H1-Mepyramine
61.54Single8X64Desloratadine8X64-H1-Desloratadine
61.54Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/&β;1/&γ;2 8JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
61.54Consensustar_onOrthosteric Ligandta1_on
60.00Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
60.00Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
60.00Single6H7N(S)-Xamoterol6H7N-β1-(S)-Xamoterol
60.00Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
60.00Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/&β;1/&γ;2
60.00Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
60.00Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/&β;1/&γ;2
60.00Single8JJLOlodaterol8JJL-β2-Olodaterol
60.00Consensusbeta1_onOrthosteric Ligand7JJO-β1-Isoprenaline-Gs/&β;1/&γ;2 8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
60.00Consensusgo_5htOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2 7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/&β;1/&γ;2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/&β;1/&γ;2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
58.82Single4AMJ(S)-Carvedilol4AMJ-β1-(S)-Carvedilol
58.82Single4IARErgotamine4IAR-5-HT1B-Ergotamine
58.82Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/&β;1/&γ;2
58.33Single6AKXA4R6AKX-CCR5-A4R
58.33Single6KUXRS-799486KUX-α2a-RS-79948
58.33Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
58.33Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/&β;1/&γ;2
58.33Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
58.33Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/&β;1/&γ;1
58.33Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
58.33Single8GGFEpinephrine8GGF-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
58.33Single8UO3Epinephrine8UO3-β2-Epinephrine-GTP; Mg-Gs/&β;1/&γ;2
58.33Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
58.33Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
58.33Consensus5ht2_onOrthosteric Ligand5ht2a_on 5ht2c_on
58.33Consensus5ht2c_onOrthosteric Ligand8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
58.33Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
58.33Consensusalpha1_onOrthosteric Ligandalpha1a_on
58.33Consensusalpha1a_onOrthosteric Ligand7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)/&β;1/&γ;2 7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2 8THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
58.33Consensusalpha2_offOrthosteric Ligandalpha2a_off alpha2c_off
58.33Consensusalpha2a_offOrthosteric Ligand6KUX-α2a-RS-79948
58.33Consensusgi_nucleotideOrthosteric Ligand7LD4-A1-Adenosine-Gi2/&β;1/&γ;2
57.14Single5C1MBU725C1M-μ-BU72
57.14Single5WIUNemonapride5WIU-D4-Nemonapride
57.14Single5WIVNemonapride5WIV-D4-Nemonapride-Na
57.14Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
57.14Single6PS6Timolol6PS6-β2-Timolol
57.14Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/&β;1/&γ;2
57.14Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
57.14Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2
57.14Consensusalpha2a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2 7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2 7W7E-α2a-W58-Go/&β;1/&γ;2 7W6P-α2a-W96-Go/&β;1/&γ;2 7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2 7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
57.14Consensusd4_offOrthosteric Ligand5WIU-D4-Nemonapride
57.14Consensusd4_off_alloOrthosteric Ligand5WIV-D4-Nemonapride-Na
57.14Consensusgo_amineOrthosteric Ligandgo_adrenergic go_muscarinic go_5ht
56.25Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
56.25Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
56.25Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/&β;1/&γ;2
56.25Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/&β;1/&γ;2
56.25Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2
56.25Single8E9YPubChem 4466038E9Y-M3-PubChem 446603-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
56.25Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/&β;1/&γ;2
55.56Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
54.55Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
54.55Single8GGZEpinephrine8GGZ-β2-Epinephrine
54.55Single8POKHistamine8POK-H2-Histamine-Gs/&β;1/&γ;2
54.55Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
53.85Single3RZECidoxepin3RZE-H1-Cidoxepin
53.85Single4MBSMaraviroc4MBS-CCR5-Maraviroc
53.85Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
53.85Single6TPGEMPA6TPG-OX2-EMPA
53.85Single6TPNHTL66416TPN-OX2-HTL6641
53.85Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
53.85Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
53.85Single7CMVPD1289077CMV-D3-PD128907-Gi1/&β;1/&γ;2
53.85Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/&β;1/&γ;2
53.85Single7F0TDopamine7F0T-D1-Dopamine-Gs/&β;1/&γ;2
53.85Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/&β;1/&γ;2
53.85Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
53.85Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/&β;1/&γ;2
53.85Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/&β;1/&γ;2
53.85Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2
53.85Single8UHBRO52563908UHB-TA1-RO5256390-Gs/&β;1/&γ;2
53.85Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/&β;1/&γ;2
53.85Consensus5ht2a_onOrthosteric Ligand7RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 6WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
53.85Consensusgs_tarOrthosteric Ligand8W88-TA1-SEP-363856-Gs/&β;1/&γ;2 8JLN-TA1-T1AM-Gs/&β;1/&γ;2 8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2 8JLQ-TA1-Fenoldopam-Gs/&β;1/&γ;2 8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2 8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2 8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
53.85Consensusm1_off_alloOrthosteric Ligand6WJC-M1-Atropine-Muscarinic toxin 7
53.85Consensusox2_offOrthosteric Ligand6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant
53.33Single4RWADIPP-NH24RWA-δ-DIPP-NH2
53.33Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
53.33Single4U15Tiotropium4U15-M3-Tiotropium
53.33Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
53.33Single6J20Aprepitant6J20-NK1-Aprepitant
53.33Single6J21Aprepitant6J21-NK1-Aprepitant
53.33Single6OL9Tiotropium6OL9-M5-Tiotropium
53.33Single6TQ7SB-3348676TQ7-OX1-SB-334867
53.33Single7CKYPW04647CKY-D1-PW0464-Gs/&β;1/&γ;2
53.33Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2
53.33Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2
53.33Single8E0GBU728E0G-μ-BU72
53.33Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/&β;1/&γ;2
53.33Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/&β;1/&γ;2
53.33Consensusa2_onOrthosteric Liganda2a_on a2b_on
53.33Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl Scopolamine 5ZHP-M3-PubChem 134828589
53.33Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
53.33Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
52.94Single4UG2CGS216804UG2-A2A-CGS21680
52.94Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/&β;1/&γ;2
52.94Single8X5YAstemizole8X5Y-H1-Astemizole
50.00Single2Y01Dobutamine2Y01-β1-Dobutamine
50.00Single4DAJTiotropium4DAJ-M3-Tiotropium
50.00Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
50.00Single4EJ4Naltrindole4EJ4-δ-Naltrindole
50.00Single4MQSIperoxo4MQS-M2-Iperoxo
50.00Single4U14Tiotropium4U14-M3-Tiotropium
50.00Single4U16N-Methyl Scopolamine4U16-M3-N-Methyl Scopolamine
50.00Single5CXVTiotropium5CXV-M1-Tiotropium
50.00Single5YC8N-Methyl Scopolamine5YC8-M2-N-Methyl Scopolamine
50.00Single5ZK8N-Methyl Scopolamine5ZK8-M2-N-Methyl Scopolamine
50.00Single5ZKCN-Methyl Scopolamine5ZKC-M2-N-Methyl Scopolamine
50.00Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
50.00Single6HLLCP999946HLL-NK1-CP99994
50.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
50.00Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
50.00Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/&β;1/&γ;2
50.00Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
50.00Single7T2GMitragynine pseudoindoxyl7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2
50.00Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
50.00Single7UL4Alvimopan7UL4-μ-Alvimopan
50.00Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/&β;1/&γ;2
50.00Single7YITNalfurafine7YIT-κ-Nalfurafine
50.00Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
50.00Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
50.00Single8GEJEpinephrine8GEJ-β2-Epinephrine-Gs/&β;1/&γ;2
50.00Single8GGCEpinephrine8GGC-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8GGEEpinephrine8GGE-β2-Epinephrine-GTP-Gs/&β;1/&γ;2
50.00Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/&β;1/&γ;2
50.00Single8JLZST19368JLZ-5-HT6-ST1936-Gs/&β;1/&γ;2
50.00Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2
50.00Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/&β;1/&γ;2
50.00Consensus5ht1a_onOrthosteric Ligand8JSP-5-HT1A-Ulotaront-Gi1/&β;1/&γ;2 7E2Z-5-HT1A-Aripiprazole-Gi1/&β;1/&γ;2 8W8B-5-HT1A-SEP-363856-Gi1/&β;1/&γ;2 7E2Y-5-HT1A-Serotonin-Gi1/&β;1/&γ;2
50.00Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/&β;1/&γ;2
50.00Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
50.00Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
50.00Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
50.00Consensusgo_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
50.00Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
50.00Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
50.00Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/&β;1/&γ;2
50.00Consensushistamine_onOrthosteric Ligandh1_on h4_on
50.00Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
50.00Consensusm4_on_alloOrthosteric Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
50.00Consensusmop_offOrthosteric Ligand7UL4-μ-Alvimopan 4DKL-μ-Beta-funaltrexamine 8QOT-μ-Nanobody E
50.00Consensusmop_onOrthosteric Ligand8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
50.00Consensusopioid_offOrthosteric Ligandkop_off mop_off nop_off dop_off
50.00Consensustachykinin_offOrthosteric Ligandnk1_off
47.37Single6HLOAprepitant6HLO-NK1-Aprepitant
47.06Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
47.06Single6DDFDamgo6DDF-μ-Damgo-Gi1/&β;1/&γ;2
47.06Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
47.06Single7XJISolabegron7XJI-β3-Solabegron-Gs/&β;1/&γ;2
47.06Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
47.06Consensusendothelin_offOrthosteric Ligandetb_off
47.06Consensusetb_offOrthosteric Ligand5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500 5X93-ETB-K-8794
47.06Consensusffa4_on_alloOrthosteric Ligand8T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
47.06Consensusgi_class-aOrthosteric Ligandgi_amine gi_lipid gi_melatonin gi_peptide gi_protein gi_nucleotide gi_hcar
46.67Single2Y00Dobutamine2Y00-β1-Dobutamine
46.67Single5WQCEMPA5WQC-OX2-EMPA
46.67Single5XPRBosentan5XPR-ETB-Bosentan
46.67Single5ZK3Quinuclidinyl benzilate hydrobromide5ZK3-M2-Quinuclidinyl benzilate hydrobromide
46.67Single6DDEDamgo6DDE-μ-Damgo-Gi1/&β;1/&γ;2
46.67Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
46.67Single7CFNINT-7777CFN-GPBA-INT-777-Gs/&β;1/&γ;2
46.67Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
46.67Single7SBFPZM217SBF-μ-PZM21-Gi1/&β;1/&γ;2
46.67Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2
46.67Single8DZQmomSalB8DZQ-κ-momSalB-Go/&β;1/&γ;2
46.67Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.67Single8EA0Iperoxo8EA0-M3-Iperoxo
46.67Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide 6DRX-5-HT2B-Lisuride
46.67Consensusa1_on_alloOrthosteric Ligand7LD3-A1-Adenosine-PubChem 25263603-Gi2/&β;1/&γ;2
46.67Consensusgo_opioidOrthosteric Ligand8DZQ-κ-momSalB-Go/&β;1/&γ;2
46.67Consensusgs_muscarinicOrthosteric Ligand8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.67Consensusm2_offOrthosteric Ligand5ZKB-M2-AF-DX 384 5ZKC-M2-N-Methyl Scopolamine 5ZK3-M2-Quinuclidinyl benzilate hydrobromide
46.67Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
46.15Single2X72All-trans-retinal2X72-Rhodopsin-All-trans-retinal-Gt(CT)
46.15Single3VGAZM2413853VGA-A2A-ZM241385-Antibody
46.15Single6AKYMaraviroc6AKY-CCR5-Maraviroc
46.15Single6ME2Ramelteon6ME2-MT1-Ramelteon
46.15Single6NWEOctyl Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
46.15Single6TODEMPA6TOD-OX1-EMPA-Na
46.15Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
46.15Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/&β;1/&γ;2
46.15Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)/&β;1/&γ;2
46.15Single8EFOPZM218EFO-μ-PZM21-Gi1/&β;1/&γ;2
46.15Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/&β;1/&γ;2
46.15Single8IW4Spermidine8IW4-TAAR9-Spermidine-chim(NtGi1-Gs)/&β;1/&γ;2
46.15Single8IWESpermidine8IWE-TAAR9-Spermidine
46.15Consensusorexin_offOrthosteric Ligandox2_off ox1_off
45.45Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
44.44Single6PT3DPI-2876PT3-δ-DPI-287
44.44Single7XY6PubChem 117178317XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
43.75Single3UONQuinuclidinyl benzilate hydrobromide3UON-M2-Quinuclidinyl benzilate hydrobromide
43.75Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
43.75Single5V54Methiothepin5V54-5-HT1B-Methiothepin
43.75Single5X93K-87945X93-ETB-K-8794
43.75Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
43.75Single6E59L-7607356E59-NK1-L-760735
43.75Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
43.75Single7B6WCyclazosin7B6W-α1b-Cyclazosin
43.75Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
43.75Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2
43.75Single8DZPmomSalB8DZP-κ-momSalB-Gi1/&β;1/&γ;2
43.75Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2
43.75Single8ID39-Hydroxystearic acid8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2
43.75Single8JD0J9R8JD0-mGlu2; mGlu3-Glutamate-J9R
43.75Single8JXVClozapine8JXV-H4-Clozapine-Gi1/&β;1/&γ;2
43.75Consensus5ht1_offOrthosteric Ligand5ht1b_off
43.75Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
43.75Consensus5ht1b_onOrthosteric Ligand6G79-5-HT1B-Donitriptan-Go/&β;1/&γ;2
43.75Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
43.75Consensusalpha1b_offOrthosteric Ligand7B6W-α1b-Cyclazosin
43.75Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/&β;1/&γ;2 8HDO-A2B-BAY 60-6583-Gs/&β;1/&γ;2 6GDG-A2A-NECA-Gs/&β;1/&γ;1 7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2 7XY6-A2B-PubChem 11717831-chim(NtGi1-Gs)/&β;1/&γ;2
43.75Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
43.75Consensussst4_onOrthosteric Ligand7XMT-SST4-J-2156-Gi1/&β;1/&γ;2
42.86Single2YDOAdenosine2YDO-A2A-Adenosine
42.86Single3UZCPubChem 1355666093UZC-A2A-PubChem 135566609
42.86Single4DKLBeta-funaltrexamine4DKL-μ-Beta-funaltrexamine
42.86Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
42.86Single4ZJCSB-6740424ZJC-OX1-SB-674042
42.86Single5TE3Octyl Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl Beta-D-Glucopyranoside
42.86Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
42.86Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
42.86Single6VI4JDTic6VI4-κ-JDTic
42.86Single7C61Ergotamine7C61-5-HT1B-Ergotamine
42.86Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/&β;1/&γ;2
42.86Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
42.86Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2
42.86Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
42.86Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
42.86Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
42.86Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6WH4-5-HT2A-Methiothepin 7VOE-5-HT2A-Aripiprazole 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 6A93-5-HT2A-Risperidone
42.86Consensusdop_off_alloOrthosteric Ligand4N6H-δ-Naltrindole-Na
42.86Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-PubChem 25001412 5DHH-NOP-SB-612111
42.86Consensusox1_offOrthosteric Ligand6TOT-OX1-Lemborexant 6TP4-OX1-ACT-462206 6TP6-OX1-Filorexant 6V9S-OX1-GTPL11403 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ7-OX1-SB-334867 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant
42.11Single8G59TUG-8918G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
42.11Consensusgi_opioidOrthosteric Ligand8EF6-μ-Morphine-Gi1/&β;1/&γ;2 8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2 7U2K-μ-C6-guano-Gi1/&β;1/&γ;2 8EFQ-μ-Damgo-Gi1/&β;1/&γ;2 8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2 8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2 8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2 7SCG-μ-FH210-Gi1/&β;1/&γ;2 7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2 7T2G-μ-Mitragynine pseudoindoxyl-Gi1/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2 8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2 7U2L-μ-PubChem 163201242-Gi1/&β;1/&γ;2 8EFO-μ-PZM21-Gi1/&β;1/&γ;2 8EFL-μ-SR17018-Gi1/&β;1/&γ;2
41.67Single3UZAGTPL92363UZA-A2A-GTPL9236
41.67Single6FUFAll-trans-retinal6FUF-Rhodopsin-All-trans-retinal-Go/&β;1/&γ;2
41.67Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
41.18Single6CM4Risperidone6CM4-D2-Risperidone
41.18Single6HLPNetupitant6HLP-NK1-Netupitant
41.18Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
41.18Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
41.18Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
41.18Single7XMTJ-21567XMT-SST4-J-2156-Gi1/&β;1/&γ;2
41.18Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/&β;1/&γ;2
41.18Single8I95EP548I95-C3aB-EP54-Go/&β;1/&γ;2
41.18Single8JWYPubChem 1684517108JWY-A2A-PubChem 168451710
41.18Single8JWZAB9288JWZ-A2A-AB928-Na
41.18Single8T3QDHA8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.91Consensusgq_class-aOrthosteric Ligandgq_amine gq_peptide
40.00Single3QAKUK-4320973QAK-A2A-UK-432097
40.00Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
40.00Single4X1HNonyl Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl Beta-D-Glucopyranoside-Gt(CT)
40.00Single5DHGPubChem 250014125DHG-NOP-PubChem 25001412
40.00Single5DSGTiotropium5DSG-M4-Tiotropium
40.00Single5MZPCaffeine5MZP-A2A-Caffeine-Na
40.00Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
40.00Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
40.00Single5UIGJ3.651.884G5UIG-A2A-J3.651.884G
40.00Single6DRXLisuride6DRX-5-HT2B-Lisuride
40.00Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
40.00Single6TOTLemborexant6TOT-OX1-Lemborexant
40.00Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
40.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
40.00Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
40.00Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
40.00Single7SCGFH2107SCG-μ-FH210-Gi1/&β;1/&γ;2
40.00Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/&β;1/&γ;2
40.00Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
40.00Single7VIES1P7VIE-S1P1-S1P-Gi1/&β;1/&γ;2
40.00Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
40.00Single8CU6LJ-45178CU6-A2A-LJ-4517
40.00Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
40.00Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/&β;1/&γ;2
40.00Single8EFQDamgo8EFQ-μ-Damgo-Gi1/&β;1/&γ;2
40.00Single8J18(3R)-3-hydroxydodecanoic acid8J18-GPR84-(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;2
40.00Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
40.00Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/&β;1/&γ;2
40.00Consensusadenosine_onOrthosteric Liganda1_on a2_on
40.00Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
40.00Consensusm2_on_alloOrthosteric Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
40.00Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
40.00Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
40.00Consensusnucleotide_onOrthosteric Ligandadenosine_on
38.89Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
38.89Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
38.89Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
38.89Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
38.89Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2
38.89Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2
38.89Single7EZCUKA7EZC-A2A-UKA
38.89Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2
38.89Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2
38.89Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
38.89Consensusclass-a_onOrthosteric Ligandsensory_on amine_on lipid_on nucleotide_on peptide_on protein_on hcar_on steroid_on melatonin_on
38.89Consensusgs_orexinOrthosteric Ligand7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
38.89Consensusorexin_onOrthosteric Ligandox2_on
38.46Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
38.46Single6TP4ACT-4622066TP4-OX1-ACT-462206
38.46Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
38.46Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
38.46Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
38.46Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/&β;1/&γ;2
38.46Consensusmt2_onOrthosteric Ligand7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
38.46Consensusox1_off_alloOrthosteric Ligand6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na 6TO7-OX1-Suvorexant-Na
38.10Single5WF5UK-4320975WF5-A2A-UK-432097
38.10Single6PT2KGCHM076PT2-δ-KGCHM07
38.10Consensusgs_class-aOrthosteric Ligandgs_amine gs_nucleotide gs_lipid gs_peptide gs_protein gs_steroid
38.10Consensusopioid_onOrthosteric Ligandkop_on mop_on nop_on dop_on
37.50Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
37.50Single5NM2ZM2413855NM2-A2A-ZM241385-Na
37.50Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
37.50Single6GDGNECA6GDG-A2A-NECA-Gs/&β;1/&γ;1
37.50Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
37.50Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
37.50Single6TP6Filorexant6TP6-OX1-Filorexant
37.50Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
37.50Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
37.50Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
37.50Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/&β;1/&γ;2
37.50Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/&β;1/&γ;2
37.50Single8J19PubChem 1270454228J19-GPR84-PubChem 127045422-Gi1/&β;1/&γ;2
37.50Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
37.50Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
37.50Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
37.50Consensusa2a_onOrthosteric Ligand6GDG-A2A-NECA-Gs/&β;1/&γ;1
36.84Single5WF6UK-4320975WF6-A2A-UK-432097
36.84Single5ZTYAM102575ZTY-CB2-AM10257
36.84Single7SK9CCX6627SK9-ACKR3-CCX662
36.84Single7XN9L-054,5227XN9-SST2-L-054,522
36.84Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
36.84Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
36.84Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_prostanoid gi_ffa gi_lpl gi_leukotriene
36.84Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on gpr119_on leuko_on lpl_on prostanoid_on
36.84Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
36.36Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
36.36Single7DW9Acyclovir triphosphate7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
36.36Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2
36.36Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
36.36Single8PWNTheophylline8PWN-A2A-Theophylline
36.36Consensusgabab_offOther Ligand7C7S-GABAB1, GABAB2-CGP54626 7CUM-GABAB1, GABAB2-CGP54626-Phospholipid 6W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
36.36Consensusv2_onOrthosteric Ligand7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
35.71Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
35.71Single5DHHSB-6121115DHH-NOP-SB-612111
35.71Single5K2DZM2413855K2D-A2A-ZM241385
35.71Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
35.71Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
35.71Single5WS3EMPA5WS3-OX2-EMPA
35.71Single6B73PubChem 1319551386B73-κ-PubChem 131955138
35.71Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/&β;1/&γ;2
35.71Single6JZHZM2413856JZH-A2A-ZM241385-Na
35.71Single6PS7ZM2413856PS7-A2A-ZM241385-Na
35.71Single7F8ULintitript7F8U-CCKA-Lintitript
35.71Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
35.71Single7M3ECa; Ca; Tryptophan; NPS-2143; PO47M3E-CaS-Ca; Ca; Tryptophan; NPS-2143; PO4
35.71Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
35.71Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2
35.71Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
35.71Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
35.71Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/&β;1/&γ;2
35.71Single7XRRLemborexant7XRR-OX2-Lemborexant
35.71Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
35.71Single8GNGIstradefylline8GNG-A2A-Istradefylline
35.71Single8HOCImetit8HOC-H4-Imetit-Gi1/&β;1/&γ;2
35.71Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
35.71Consensusa2a_off_alloOrthosteric Ligand6ZDR-A2A-HMS1413f12-Na 6GT3-A2A-Imaradenant-Na 8CU7-A2A-LJ-4517-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PubChem 92460631; psb36-Na 5MZJ-A2A-Theophylline-Na 5OLO-A2A-Tozadenant-Na 5OLH-A2A-Vipadenant-Na 5NM4-A2A-ZM241385-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5MZP-A2A-Caffeine-Na 8CIC-A2A-Etrumadenant-Na
35.71Consensusgi_histamineOrthosteric Ligand8HN8-H4-Histamine-Gi1/&β;1/&γ;2 8HOC-H4-Imetit-Gi1/&β;1/&γ;2
35.71Consensusgs_histamineOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.71Consensush4_onOrthosteric Ligand7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.71Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/&β;1/&γ;2
35.71Consensusmelatonin_onOrthosteric Ligandmt1_on mt2_on
35.29Single4DJHJDTic4DJH-κ-JDTic
35.29Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
35.29Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
35.29Single7EPENAM5637EPE-mGlu-NAM563
35.29Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
35.29Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2
35.29Single7EW7PubChem 40774607EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
35.29Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/&β;1/&γ;2
35.29Single7TUYGSK682753A7TUY-GPR183-GSK682753A
35.29Single7W41PD1762527W41-BB2-PD176252
35.29Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/&β;1/&γ;2
35.29Single8EFLSR170188EFL-μ-SR17018-Gi1/&β;1/&γ;2
35.29Single8G056-OAU8G05-GPR84-6-OAU-Gi1/&β;1/&γ;2
35.29Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/&β;1/&γ;2
35.29Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.29Single8ID6Oleic acid8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2
35.29Single8JXWVUF68848JXW-H4-VUF6884-Gi1/&β;1/&γ;2
35.29Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/&β;1/&γ;2
35.29Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
35.29Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
35.29Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
35.29Consensusadenosine_offOrthosteric Liganda1_off a2_off
35.29Consensusangiotensin_offOrthosteric Ligandat1_off at2_off
35.29Consensusarrestin2Orthosteric Ligand6TKO-β1-Arformoterol-Arrestin2 6PWC-NTS1-Neurotensin-Arrestin2 7R0C-V2-Acyclovir triphosphate-Arrestin2
35.29Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
35.29Consensusbombesin_offOrthosteric Ligandbb2_off
35.29Consensusclass-a_offOrthosteric Ligandsensory_off amine_off lipid_off nucleotide_off peptide_off protein_off hcar_off
35.29Consensusffa4_onOrthosteric Ligand8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
35.29Consensusgi_muscarinicOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
35.29Consensusgs_compl-peptideOrthosteric Ligand8I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.29Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
35.29Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
35.29Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/&β;1/&γ;2
35.00Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
35.00Single7W0PElabela7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
35.00Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
35.00Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2
35.00Consensusapelin_onOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
34.78Single7KH0Acyclovir triphosphate7KH0-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single3REYPubChem 56973REY-A2A-PubChem 5697
33.33Single3RFMCaffeine3RFM-A2A-Caffeine
33.33Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
33.33Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
33.33Single5IU4ZM2413855IU4-A2A-ZM241385-Na
33.33Single5IU7Q274563465IU7-A2A-Q27456346-Na
33.33Single5IUBQ274563445IUB-A2A-Q27456344-Na
33.33Single5JTBZM2413855JTB-A2A-ZM241385
33.33Single5K2BZM2413855K2B-A2A-ZM241385-Na
33.33Single5K2CZM2413855K2C-A2A-ZM241385-Na
33.33Single5NLXZM2413855NLX-A2A-ZM241385-Na
33.33Single5NM4ZM2413855NM4-A2A-ZM241385-Na
33.33Single6A93Risperidone6A93-5-HT2A-Risperidone
33.33Single6AQFZM2413856AQF-A2A-ZM241385
33.33Single6DS0Ly2660976DS0-5-HT2B-Ly266097
33.33Single6IQLL7458706IQL-D4-L745870
33.33Single6OY9All-trans-retinal6OY9-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
33.33Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
33.33Single6V9SGTPL114036V9S-OX1-GTPL11403
33.33Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
33.33Single6ZDVPubChem 9840736ZDV-A2A-PubChem 984073-Na
33.33Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
33.33Single6ZG4HTL00099366ZG4-M1-HTL0009936
33.33Single7AROLUF58337ARO-A2A-LUF5833-Na
33.33Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
33.33Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
33.33Single7DFPSpiperone7DFP-D2-Spiperone
33.33Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/&β;1/&γ;2
33.33Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/&β;1/&γ;2
33.33Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2
33.33Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
33.33Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
33.33Single7MTBAll-trans-retinal7MTB-Rhodopsin-All-trans-retinal-GRK1
33.33Single7T32ZM2413857T32-A2A-ZM241385
33.33Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/&β;1/&γ;2
33.33Single7WCNAR2314537WCN-GPR119-AR231453-Gs/&β;1/&γ;2
33.33Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
33.33Single7Y24Octreotide7Y24-SST2-Octreotide-Go/&β;1/&γ;2
33.33Single8A2OTheophylline8A2O-A2A-Theophylline-Na
33.33Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/&β;1/&γ;2
33.33Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
33.33Single8GURPubChem 1048958GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2
33.33Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2
33.33Single8IJDMK68928IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
33.33Single8IWM2-Phenylethylamine8IWM-TAAR9-2-Phenylethylamine
33.33Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/&β;1/&γ;2
33.33Single8WC5Tetramethylammonium ion8WC5-TA1-Tetramethylammonium ion-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Single8WU1KCA8WU1-CB1-KCA-Arrestin1
33.33Consensusalpha1_offOrthosteric Ligandalpha1a_off alpha1b_off
33.33Consensusat2_offOrthosteric Ligand7JNI-AT2-Olodanrigan
33.33Consensuscannabinoid_offOrthosteric Ligandcb1_off cb2_off
33.33Consensusgi_lplOrthosteric Ligand7EW3-S1P3-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW4-S1P3-CYM5541-Gi1/&β;1/&γ;2 7EW2-S1P3-Fingolimod-Gi1/&β;1/&γ;2 7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
33.33Consensusgi_melatoninOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2 7VH0-MT2-Ramelteon-Gi1/&β;1/&γ;1
33.33Consensusgs_bileacidOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
33.33Consensusgs_steroidOrthosteric Ligandgs_bileacid
33.33Consensusgs_trhOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
33.33Consensusgs_vasopressin-otOrthosteric Ligand7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 7DW9-V2-Acyclovir triphosphate-chim(NtGi1-Gs)/&β;1/&γ;2
33.33Consensush3_on_alloOrthosteric Ligand7F61-H3-PF-03654746-Cholesterol
33.33Consensushca2_on_alloOrthosteric Ligand8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2 8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
33.33Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2 8DZR-κ-GR89,696-chim(NtGi2-Gt3)/&β;1/&γ;2 8DZP-κ-momSalB-Gi1/&β;1/&γ;2 8FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
33.33Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z34-LPA1-ONO-9780307 4Z35-LPA1-ONO-9910539 7YU4-LPA1-ONO-0740556
33.33Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/&β;1/&γ;2 7TRK-M4-Iperoxo-Gi1/&β;1/&γ;2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/&β;1/&γ;2 7V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
33.33Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
33.33Consensuspeptide_offOrthosteric Ligandopioid_off angiotensin_off bombesin_off cck_off endothelin_off ghrelin_off npy_off nts_off orexin_off vasopressin-ot_off tachykinin_off sst_off
33.33Consensussensory_onOrthosteric Ligandopsin_on
33.33Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
31.82Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
31.82Single7TD0LPA7TD0-LPA1-LPA-Gi1/&β;1/&γ;2
31.82Consensusangiotensin_onOrthosteric Ligandat1_on
31.82Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
31.58Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
31.58Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
31.58Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
31.58Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
31.58Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/&β;1/&γ;2
31.58Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/&β;1/&γ;2
31.58Single7XK2MK68927XK2-HCA2-MK6892-Gi1/&β;1/&γ;2
31.58Single7XZ6APD6687XZ6-GPR119-APD668-Gs/&β;1/&γ;2
31.58Single8ID8TUG-8918ID8-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2
31.58Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/&β;1/&γ;2
31.58Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/&β;1/&γ;2
31.58Consensusbileacid_onOrthosteric Ligand7CFN-GPBA-INT-777-Gs/&β;1/&γ;2 7CFM-GPBA-P395-Gs/&β;1/&γ;2 7XTQ-GPBA-R399-Gs/&β;1/&γ;2
31.58Consensuss1p1_onOrthosteric Ligand7TD3-S1P1-S1P-Gi1/&β;1/&γ;2 7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2 7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2 7EO4-S1P1-BAF312-Gi1/&β;1/&γ;2 7VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2 7EVZ-S1P1-Cenerimod-Gi1/&β;1/&γ;2 7EW0-S1P1-Ozanimod-Gi1/&β;1/&γ;2 7EW7-S1P1-PubChem 4077460-Gi1/&β;1/&γ;2
31.58Consensussteroid_onOrthosteric Ligandbileacid_on
31.25Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
31.25Single3EMLZM2413853EML-A2A-ZM241385
31.25Single4EIYZM2413854EIY-A2A-ZM241385-Na
31.25Single5IU8Q274563475IU8-A2A-Q27456347-Na
31.25Single5K2AZM2413855K2A-A2A-ZM241385-Na
31.25Single5OLGZM2413855OLG-A2A-ZM241385-Na
31.25Single5UENDU1725UEN-A1-DU172
31.25Single5VRAZM2413855VRA-A2A-ZM241385-Na
31.25Single6LPJZM2413856LPJ-A2A-ZM241385-Na
31.25Single6LPKZM2413856LPK-A2A-ZM241385-Na
31.25Single6S0LZM2413856S0L-A2A-ZM241385
31.25Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
31.25Single7PYRPSB-21157PYR-A2A-PSB-2115
31.25Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
31.25Single8ID4Linoleic acid8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2
31.25Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
31.25Consensusa2_offOrthosteric Liganda2a_off
31.25Consensusa2a_offOrthosteric Ligand8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 5UIG-A2A-J3.651.884G 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-PubChem 168451710 5K2D-A2A-ZM241385
31.25Consensusgi_hcaOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2
31.25Consensusgi_hcarOrthosteric Ligandgi_hca
31.25Consensushca2_onOrthosteric Ligand8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2 8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2 8IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2 8IHF-HCA2-MK6892-Gi1/&β;1/&γ;2 8JHY-HCA2-Compound 9n-Gi1/&β;1/&γ;2 8IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2 8JIM-HCA2-MMF-Gi1/&β;1/&γ;2 8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2 8IJD-HCA2-MK6892-Gi1/&β;1/&γ;2 8J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
31.25Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
30.77Single5WKTOctyl Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl Beta-D-Glucopyranoside-Gt(CT)
30.77Single6ME5Agomelatine6ME5-MT1-Agomelatine
30.77Single6ME9Ramelteon6ME9-MT2-Ramelteon
30.77Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/&β;1/&γ;2
30.77Single7WC5Psilocin7WC5-5-HT2A-Psilocin
30.77Single8IW72-Phenylethylamine8IW7-TAAR9-2-Phenylethylamine-chim(NtGi1-Gs)/&β;1/&γ;2
30.77Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
30.77Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2
30.77Single8J6QBeta-hydroxybutyrate8J6Q-HCA2-Beta-hydroxybutyrate-Compound 9n-Gi1/&β;1/&γ;2
30.77Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/&β;1/&γ;2
30.77Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
30.77Consensusgq_peptideOrthosteric Ligandgq_cck gq_angiotensin gq_bombesin gq_bradykinin
30.77Consensusopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
30.77Consensuspeptide_onOrthosteric Ligandopioid_on angiotensin_on bombesin_on cck_on endothelin_on ghrelin_on npy_on nts_on orexin_on vasopressin-ot_on tachykinin_on sst_on relaxin_on trh_on nmur_on motilin_on melanocortin_on galanin_on fpr-alx_on compl-peptide_on bradykinin_on apelin_on
30.43Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
30.43Single8IHFMK68928IHF-HCA2-MK6892-Gi1/&β;1/&γ;2
30.43Single8J6IMK68928J6I-HCA2-MK6892-Gi1/&β;1/&γ;2
30.43Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/&β;1/&γ;2
30.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
30.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
30.00Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/&β;1/&γ;2
30.00Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/&β;1/&γ;2
30.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
30.00Single8IYHMK68928IYH-HCA2-MK6892-Go/&β;1/&γ;2
30.00Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2 8I95-C3aB-EP54-Go/&β;1/&γ;2
30.00Consensusgi_apelinOrthosteric Ligand7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
30.00Consensuslpl_offOrthosteric Ligands1p_off lpa_off
30.00Consensuslpl_onOrthosteric Ligands1p_on lpa_on
29.63Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
29.63Consensusgi_peptideOrthosteric Ligandgi_opioid gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_neuromedin gi_neurotensin gi_relaxin gi_neuropeptide gi_somatostatin gi_apelin gi_compl-peptide gi_cck
29.63Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/&β;1/&γ;2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
29.41Single5IUAQ274563485IUA-A2A-Q27456348-Na
29.41Single5N2RPubChem 92460631; psb365N2R-A2A-PubChem 92460631; psb36-Na
29.41Single5N2SPSB365N2S-A1-PSB36
29.41Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
29.41Single6D26Fevipiprant6D26-DP2-Fevipiprant
29.41Single6LPLZM2413856LPL-A2A-ZM241385-Na
29.41Single6LUQHaloperidol6LUQ-D2-Haloperidol
29.41Single6S0QZM2413856S0Q-A2A-ZM241385
29.41Single6WQAZM2413856WQA-A2A-ZM241385-Na
29.41Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/&β;1/&γ;2
29.41Single7EW3S1P7EW3-S1P3-S1P-Gi1/&β;1/&γ;2
29.41Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
29.41Single7RM5ZM2413857RM5-A2A-ZM241385-Na
29.41Single7SINNPS-21437SIN-CaS-NPS-2143
29.41Single7SINNPS-21437SIN-CaS-NPS-2143
29.41Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
29.41Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/&β;1/&γ;2
29.41Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/&β;1/&γ;2
29.41Single8FYNZM2413858FYN-A2A-ZM241385-Na
29.41Single8GNEKW-63568GNE-A2A-KW-6356-Na
29.41Single8ID9Eicosapentaenoic acid8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2
29.41Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/&β;1/&γ;2
29.41Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/&β;1/&γ;2
29.41Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/&β;1/&γ;2
29.41Single8QOTNanobody E8QOT-μ-Nanobody E
29.41Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/&β;1/&γ;2
29.41Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
29.41Consensuscb2_onOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
29.41Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
29.41Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/&β;1/&γ;2
29.17Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
29.17Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/&β;1/&γ;2
29.17Consensusbombesin_onOrthosteric Ligandbb2_on bb1_on
28.57Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
28.57Single2G87All-trans-retinal2G87-Rhodopsin-All-trans-retinal
28.57Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
28.57Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
28.57Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
28.57Single6QNOAll-trans-retinal6QNO-Rhodopsin-All-trans-retinal-Gi1/&β;1/&γ;1
28.57Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
28.57Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single7F8XNN90567F8X-CCKA-NN9056
28.57Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
28.57Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/&β;1/&γ;2
28.57Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.57Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
28.57Single8GHVPubChem 1459649038GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
28.57Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/&β;1/&γ;2
28.57Single8HN8Histamine8HN8-H4-Histamine-Gi1/&β;1/&γ;2
28.57Single8IJANiacin8IJA-HCA2-Niacin-Gi1/&β;1/&γ;2
28.57Single8ITFDMCHA8ITF-TAAR9-DMCHA-chim(NtGi1-Gs)/&β;1/&γ;2
28.57Single8IY9Niacin8IY9-HCA2-Niacin-Go/&β;1/&γ;2
28.57Single8J6RMK68928J6R-HCA2-MK6892-Gi1/&β;1/&γ;2
28.57Single8K5BNiacin8K5B-HCA2-Niacin
28.57Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
28.57Consensusgo_class-aOrthosteric Ligandgo_amine go_peptide go_protein
28.57Consensusmt1_onOrthosteric Ligand7VGY-MT1-2-Iodomelatonin-Gi1/&β;1/&γ;2 7DB6-MT1-Ramelteon-Gi1/&β;1/&γ;2
28.57Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/&β;1/&γ;2
28.57Consensussst_onOrthosteric Ligandsst2_on sst4_on
28.00Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
28.00Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00Consensusbb1_onOrthosteric Ligand8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
28.00Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2
27.78Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
27.78Single5XR8AM8415XR8-CB1-AM841
27.78Single5XRAAM115425XRA-CB1-AM11542
27.78Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
27.78Single7PX4PSB-21137PX4-A2A-PSB-2113
27.78Single7TD1LPA7TD1-LPA1-LPA-Gi1/&β;1/&γ;2
27.78Single7WV9PubMed 1048957WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
27.78Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2
27.78Single7XTQR3997XTQ-GPBA-R399-Gs/&β;1/&γ;2
27.78Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/&β;1/&γ;2
27.78Consensuscck_onOrthosteric Ligandccka_on cckb_on
27.78Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
27.78Consensuscyslt1_off_ortoalloOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
27.78Consensusgi_ffaOrthosteric Ligand8ID6-FFA4 (GPR120)-Oleic acid-Gi1/&β;1/&γ;2 8G59-FFA4 (GPR120)-TUG-891-Gi1/&β;1/&γ;2 8ID3-FFA4 (GPR120)-9-Hydroxystearic acid-Gi1/&β;1/&γ;2 8ID9-FFA4 (GPR120)-Eicosapentaenoic acid-Gi1/&β;1/&γ;2 8ID4-FFA4 (GPR120)-Linoleic acid-Gi1/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2 8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8J21-FFA3-Butyric acid-Gi1/&β;1/&γ;2
27.78Consensusgs_ffaOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8T3Q-FFA4-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2 8GDB-EP4-PGE2-Gs/&β;1/&γ;2
27.78Consensuslpa1_onOrthosteric Ligand7TD0-LPA1-LPA-Gi1/&β;1/&γ;2 7YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
27.78Consensuslpa_offOrthosteric Ligandlpa1_off
27.78Consensuslpa_onOrthosteric Ligandlpa1_on
27.78Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
27.78Consensusnpy_offOrthosteric Ligandnpy2_off npy1_off
27.27Single6DO1Angiotensin-Like peptide S1I86DO1-AT1-Angiotensin-Like peptide S1I8
27.27Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/&β;1/&γ;2
27.27Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/&β;1/&γ;2
27.27Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/&β;1/&γ;2
27.27Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
27.27Single8WCBCyclohexylammonium ion8WCB-TA1-Cyclohexylammonium ion-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
27.27Single8WCCCyclohexylammonium ion8WCC-TA1-Cyclohexylammonium ion
27.27Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2 7F8V-CCKB-Gastrin-17-Gi2/&β;1/&γ;2
26.92Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
26.92Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2
26.92Consensusendothelin_onOrthosteric Ligandetb_on eta_on
26.67Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
26.67Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
26.67Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
26.67Single3PWHZM2413853PWH-A2A-ZM241385
26.67Single3VG9ZM2413853VG9-A2A-ZM241385-Antibody
26.67Single4S0VSuvorexant4S0V-OX2-Suvorexant
26.67Single6OYAAll-trans-retinal6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
26.67Single6TPJSuvorexant6TPJ-OX2-Suvorexant
26.67Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
26.67Single7TUZ7alpha,25-dihydroxycholesterol7TUZ-GPR183-7alpha,25-dihydroxycholesterol-Gi1/&β;1/&γ;2
26.67Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/&β;1/&γ;2
26.67Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
26.67Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
26.67Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/&β;1/&γ;2
26.67Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
26.67Consensusffa3_on_alloOrthosteric Ligand8J20-FFA3-Valeric acid-AR420626-Gi1/&β;1/&γ;2
26.67Consensusgi_neuropeptideOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2 7X9C-Y4-Pancreatic Hormone-Gi1/&β;1/&γ;2 7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
26.67Consensusgt_class-aOrthosteric Ligandgt_opsin
26.67Consensusgt_opsinOrthosteric Ligandgt_sensory
26.67Consensusgt_sensoryOrthosteric Ligand6OYA-Rhodopsin-All-trans-retinal-Gt/&β;1/&γ;1
26.67Consensusmglu_onOther Ligandmglu2_on mglu4_on
26.67Consensusnpy1_onOrthosteric Ligand7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
26.67Consensusnpy_onOrthosteric Ligandnpy2_on npy4_on npy1_on
26.67Consensusopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
26.32Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
26.32Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
26.32Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
26.32Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
26.32Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
26.32Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
26.32Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
26.32Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
26.32Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2
26.32Consensuscannabinoid_onOrthosteric Ligandcb1_on cb2_on
26.32Consensuscb1_onOrthosteric Ligand8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
26.32Consensusdp2_offOrthosteric Ligand6D27-DP2-CAY10471 6D26-DP2-Fevipiprant
26.32Consensusdp_offOrthosteric Liganddp2_off
26.32Consensusgi_cannabinoidOrthosteric Ligand8GUS-CB2-HU-308-Gi1/&β;1/&γ;2 8GUT-CB2-LEI-102-Gi1/&β;1/&γ;2 8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2 8GUR-CB2-PubChem 104895-Gi1/&β;1/&γ;2 6KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2 6PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2 6KPG-CB1-AM841-Gi1/&β;1/&γ;2 6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2 8GHV-CB1-PubChem 145964903-Gi1/&β;1/&γ;2
26.32Consensusgi_class-fOther Ligandgi_frizzled
26.32Consensusgi_frizzledOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
26.32Consensusgpr119_onOrthosteric Ligand7XZ6-GPR119-APD668-Gs/&β;1/&γ;2 7WCN-GPR119-AR231453-Gs/&β;1/&γ;2 7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2 7WCM-GPR119-MBX-2982-Gs/&β;1/&γ;2
26.32Consensusleuko_offOrthosteric Ligandblt_off cyslt_off
26.32Consensuss1p_onOrthosteric Ligands1p3_on s1p5_on s1p1_on s1p2_on
26.09Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1
26.09Single7TD2LPA7TD2-LPA1-LPA-Gi1/&β;1/&γ;2
26.09Consensusgi_chemerinOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
26.09Consensusgi_formylpeptideOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2 7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
25.93Single6IGLIRL16206IGL-ETB-IRL1620
25.93Single7VGXNeuropeptide Y7VGX-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
25.93Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2
25.93Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
25.93Consensusgs_endothelinOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.93Consensusgs_peptideOrthosteric Ligandgs_cck gs_motilin gs_neuromedin gs_orexin gs_sst gs_tachykinin gs_trh gs_vasopressin-ot gs_bombesin gs_bradykinin gs_compl-peptide gs_endothelin gs_galanin gs_ghrelin gs_melanocortin
25.00Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
25.00Single3PXOAll-trans-retinal3PXO-Rhodopsin-All-trans-retinal
25.00Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
25.00Single5DYSAll-trans-retinal5DYS-Rhodopsin-All-trans-retinal
25.00Single5GLHEndothelin-15GLH-ETB-Endothelin-1
25.00Single5UVIZM2413855UVI-A2A-ZM241385
25.00Single6IGKEndothelin-36IGK-ETB-Endothelin-3
25.00Single6JODAngiotensin II6JOD-AT2-Angiotensin II
25.00Single6K1QIRL25006K1Q-ETB-IRL2500
25.00Single6MH8ZM2413856MH8-A2A-ZM241385
25.00Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
25.00Single6TP3Nemorexant6TP3-OX1-Nemorexant
25.00Single6TPKRetosiban6TPK-OT-Retosiban
25.00Single6WI9Secretin6WI9-Secretin-Secretin-Gs/&β;1/&γ;2
25.00Single7BB6Acyclovir triphosphate7BB6-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
25.00Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/&β;1/&γ;2
25.00Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2
25.00Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single7VODCariprazine7VOD-5-HT2A-Cariprazine
25.00Single7WC4Serotonin7WC4-5-HT2A-Serotonin
25.00Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2
25.00Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
25.00Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
25.00Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
25.00Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
25.00Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
25.00Single8GAGYVF8GAG-CB1-YVF-Gi1/&β;1/&γ;2
25.00Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/&β;1/&γ;2
25.00Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/&β;1/&γ;2
25.00Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/&β;1/&γ;2
25.00Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
25.00Single8JERAcipimox8JER-HCA2-Acipimox-Go/&β;1/&γ;2
25.00Single8JHNMMF8JHN-HCA2-MMF-Go/&β;1/&γ;2
25.00Single8JIMMMF8JIM-HCA2-MMF-Gi1/&β;1/&γ;2
25.00Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/&β;1/&γ;2
25.00Single8K5CAcipimox8K5C-HCA2-Acipimox
25.00Single8WRZ8D08WRZ-CB1-8D0-Arrestin1
25.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
25.00Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
25.00Consensuscckb_onOrthosteric Ligand7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2
25.00Consensusffa2_onOrthosteric Ligand8J24-FFA2-Acetic acid-Gi1/&β;1/&γ;2 8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
25.00Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
25.00Consensusgi_somatostatinOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XMT-SST4-J-2156-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
25.00Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;1 7XOV-CCKA-SR146131-Gs/&β;1/&γ;2
25.00Consensushca_onOrthosteric Ligandhca2_on hca3_on
25.00Consensushcar_onOrthosteric Ligandhca_on
25.00Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
25.00Consensusot_onOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
25.00Consensuss1p1_offOrthosteric Ligand3V2Y-S1P1-PubChem 51892645
25.00Consensuss1p_offOrthosteric Ligands1p1_off
25.00Consensussensory_offOrthosteric Ligandopsin_off
25.00Consensusvasopressin-ot_offOrthosteric Ligandot_off
24.14Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
24.00Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/&β;1/&γ;2
24.00Single7X9BNeuropeptide Y7X9B-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
24.00Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
24.00Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
24.00Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
24.00Consensusbk1_onOrthosteric Ligand7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Consensusc5a1_onOrthosteric Ligand7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2 8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2
24.00Consensusgs_bradykininOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
24.00Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2
23.81Single5EE7MK08935EE7-Glucagon-MK0893
23.81Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/&β;1/&γ;2
23.81Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.81Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2
23.81Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/&β;1/&γ;2
23.81Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/&β;1/&γ;2
23.81Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2
23.81Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/&β;1/&γ;2 7T6T-FPR1-ALX-fMLFII-Gi1/&β;1/&γ;2
23.81Consensusfpr2-alx_onOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-Beta42-Gi2/&β;1/&γ;2 7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2 7WVV-FPR2-ALX-fMLFII-Gi2/&β;1/&γ;2 7WVW-FPR2-ALX-fMYFINILTL-Gi2/&β;1/&γ;2 7WVX-FPR2-ALX-Humanin-Gi2/&β;1/&γ;2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/&β;1/&γ;2 6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
23.81Consensusgo_compl-peptideOrthosteric Ligand8I95-C3aB-EP54-Go/&β;1/&γ;2 8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2 8I9L-C3aB-C3a anaphylatoxin-Go/&β;1/&γ;2 8J6D-C3aB-EP141-Go/&β;1/&γ;2
23.81Consensusgo_vasopressinOrthosteric Ligand7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
23.81Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/&β;1/&γ;2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/&β;1/&γ;2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/&β;1/&γ;2 7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
23.81Consensusgs_bombesinOrthosteric Ligand8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
23.53Single4YAYZD-71554YAY-AT1-ZD-7155
23.53Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
23.53Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
23.53Single6D27CAY104716D27-DP2-CAY10471
23.53Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/&β;1/&γ;2
23.53Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
23.53Single7CFMP3957CFM-GPBA-P395-Gs/&β;1/&γ;2
23.53Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
23.53Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
23.53Single7V3ZPubMed 1048957V3Z-CB1-PubMed 104895
23.53Single7VIF(S)-FTY720-P7VIF-S1P1-(S)-FTY720-P-Gi1/&β;1/&γ;2
23.53Single7VKTLTB47VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
23.53Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
23.53Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/&β;1/&γ;2
23.53Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/&β;1/&γ;2
23.53Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/&β;1/&γ;2
23.53Single8K5DGSK2560738K5D-HCA2-GSK256073
23.53Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
23.53Consensusblt_onOrthosteric Ligandblt1_on
23.53Consensuscb1_on_alloOrthosteric Ligand7WV9-CB1-PubMed 104895-ZCZ011-Gi2/&β;1/&γ;2
23.53Consensuscck_offOrthosteric Ligandccka_off
23.53Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
23.53Consensusffa_onOrthosteric Ligandffa4_on ffa1_on ffa2_on ffa3_on
23.53Consensusfsh_on_alloOther Ligand8I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
23.53Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/&β;1/&γ;2
23.53Consensusleuko_onOrthosteric Ligandblt_on
23.53Consensuslipid_offOrthosteric Ligandcannabinoid_off leuko_off lpl_off paf_off prostanoid_off
23.53Consensusp2y12_offOrthosteric Ligand4NTJ-P2Y12-AZD1283 7PP1-P2Y12-Selatogrel
23.33Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
23.08Single6TQ9SB-4081246TQ9-OX1-SB-408124
23.08Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/&β;1/&γ;2
23.08Consensusbradykinin_onOrthosteric Ligandbk2_on bk1_on
23.08Consensusgi_compl-peptideOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2 8IA8-C3aB-E7 peptide-Gi1/&β;1/&γ;2 7Y66-C5a1-BM213-Gi1/&β;1/&γ;2 7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2 8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2 7Y64-C5a1-C5a anaphylatoxin-Gi1/&β;1/&γ;2 7Y65-C5a1-C5a peptide-Gi1/&β;1/&γ;2
23.08Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2 7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
22.73Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/&β;1/&γ;2
22.73Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
22.73Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/&β;1/&γ;2
22.73Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin 8HN1-Alpha1A-Toxin AdTx1
22.73Consensusfpr-alx_onOrthosteric Ligandfpr1-alx_on fpr2-alx_on
22.73Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
22.73Consensussst2_onOrthosteric Ligand7XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2 7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2 7YAC-SST2-Paltusotine-Gi1/&β;1/&γ;2
22.58Single7X9ANeuropeptide Y7X9A-Y1-Neuropeptide Y-Gi1/&β;1/&γ;2
22.22Single4NTJAZD12834NTJ-P2Y12-AZD1283
22.22Single4WW3All-trans-retinal4WW3-Rhodopsin-All-trans-retinal
22.22Single5CGCHTL142425CGC-mGlu5-HTL14242
22.22Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
22.22Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
22.22Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
22.22Single7BB7Acyclovir triphosphate7BB7-V2-Acyclovir triphosphate-Gs/&β;1/&γ;2
22.22Single7C4SS1P7C4S-S1P3-S1P
22.22Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
22.22Single7F53Alpha-MSH7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2
22.22Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/&β;1/&γ;2
22.22Single7TD3S1P7TD3-S1P1-S1P-Gi1/&β;1/&γ;2
22.22Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Single7Y27Somatostatin-147Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
22.22Single7YOONeuropeptide Y7YOO-Y2-Neuropeptide Y-Gi1/&β;1/&γ;2
22.22Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
22.22Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
22.22Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
22.22Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
22.22Consensusetb_onOrthosteric Ligand8HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2 8HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
22.22Consensusgo_class-b1Orthosteric Ligandgo_crf
22.22Consensusgo_crfOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
22.22Consensusgs_sstOrthosteric Ligand7Y27-SST2-Somatostatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
21.74Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
21.74Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
21.74Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/&β;1/&γ;2
21.74Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
21.74Single8F7QBeta-endorphin8F7Q-μ-Beta-endorphin-Gi1/&β;1/&γ;2
21.74Consensusvasopressin-ot_onOrthosteric Ligandot_on v2_on
21.43Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
21.43Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
21.43Single3PQRAll-trans-retinal3PQR-Rhodopsin-All-trans-retinal-Gt(CT)
21.43Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2
21.43Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
21.43Single7MT8All-trans-retinal7MT8-Rhodopsin-All-trans-retinal-GRK1
21.43Single7MT9All-trans-retinal7MT9-Rhodopsin-All-trans-retinal-GRK1
21.43Single7MTAAll-trans-retinal7MTA-Rhodopsin-All-trans-retinal-GRK1
21.43Single8EITDoconexent8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
21.43Single8F76-8F76-OR51E2-Gs/&β;1/&γ;2
21.43Single8FEGPRD_0025178FEG-κ-PRD_002517-Gi1/&β;1/&γ;2
21.43Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/&β;1/&γ;2
21.05Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
21.05Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
21.05Single7F58THIQ7F58-MC4-THIQ-Gs/&β;1/&γ;2
21.05Single7FEEPubMed 1048957FEE-CB1-PubMed 104895-ZCZ011
21.05Single7R0CAcyclovir triphosphate7R0C-V2-Acyclovir triphosphate-Arrestin2
21.05Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/&β;1/&γ;2
21.05Single7XOWGastrin7XOW-CCKB-Gastrin-Gq/&β;1/&γ;2
21.05Single7XOXCholecystokinin-87XOX-CCKB-Cholecystokinin-8-Gq/&β;1/&γ;2
21.05Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/&β;1/&γ;2
21.05Single8GUSHU-3088GUS-CB2-HU-308-Gi1/&β;1/&γ;2
21.05Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones alpha chain-Compound 716340-Gs/&β;1/&γ;2
21.05Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/&β;1/&γ;2
21.05Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/&β;1/&γ;2
21.05Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/&β;1/&γ;2
21.05Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
21.05Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
21.05Consensuschemerin_onOrthosteric Ligandcml1_on
21.05Consensuscml1_onOrthosteric Ligand8SG1-CML1-Chemerin-9-Gi1/&β;1/&γ;2
20.83Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
20.83Single6W25SHU91196W25-MC4-SHU9119-Ca
20.83Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2
20.83Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/&β;1/&γ;2
20.83Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/&β;1/&γ;2
20.69Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
20.69Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
20.00Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
20.00Single3AYMAll-trans-retinal3AYM-Rhodopsin-All-trans-retinal
20.00Single3OE9IT1t3OE9-CXCR4-IT1t
20.00Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
20.00Single4N4WSANT-14N4W-SMO-SANT-1
20.00Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
20.00Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
20.00Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
20.00Single6KQIPubMed 1048956KQI-CB1-PubMed 104895-ORG27569
20.00Single6LPBPACAP6LPB-PAC1-PACAP-Gs/&β;1/&γ;1
20.00Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
20.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
20.00Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
20.00Single7K15MKD0467K15-BLT1-MKD046-Na
20.00Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
20.00Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
20.00Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/&β;1/&γ;2
20.00Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/&β;1/&γ;2
20.00Single7Y66BM2137Y66-C5a1-BM213-Gi1/&β;1/&γ;2
20.00Single7YONPeptide YY(3-36)7YON-Y2-Peptide YY(3-36)-Gi1/&β;1/&γ;2
20.00Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
20.00Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/&β;1/&γ;2
20.00Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/&β;1/&γ;2
20.00Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/&β;1/&γ;2
20.00Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/&β;1/&γ;2
20.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
20.00Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/&β;1/&γ;2
20.00Single8J6DEP1418J6D-C3aB-EP141-Go/&β;1/&γ;2
20.00Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg3_on
20.00Consensusbk2_onOrthosteric Ligand7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
20.00Consensusblt1_offOrthosteric Ligand7K15-BLT1-MKD046-Na
20.00Consensusblt_offOrthosteric Ligandblt1_off
20.00Consensuscb1_off_alloOrthosteric Ligand6KQI-CB1-PubMed 104895-ORG27569
20.00Consensusclass-b2_onOrthosteric Ligandadgrg_on
20.00Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
20.00Consensusmelanocortin_onOrthosteric Ligandmc2_on mc1_on mc3_on mc4_on mc5_on
20.00Consensustsh_on_alloOther Ligand7XW5-TSH-TSH-ML109-Gs/&β;1/&γ;2
19.23Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
19.23Single7F6IKallidin7F6I-BK2-Kallidin-Gq/&β;1/&γ;2
19.23Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
19.23Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/&β;1/&γ;2
19.23Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
19.23Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2
19.23Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2
19.23Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.23Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/&β;1/&γ;2
19.23Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
19.23Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Single5CGDHTL142425CGD-mGlu5-HTL14242
19.05Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2
19.05Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/&β;1/&γ;2
19.05Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Consensusfpa_onOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
19.05Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.75Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
18.75Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
18.75Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
18.75Single7BR3Elagolix7BR3-GnRH1-Elagolix
18.75Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
18.75Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
18.75Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
18.75Single7W0OElabela7W0O-Apelin-Elabela-Gi1/&β;1/&γ;2
18.75Single7WF7S1P7WF7-S1P1-S1P-Gi1/&β;1/&γ;2
18.75Single8A6CAll-trans-retinal8A6C-Rhodopsin-All-trans-retinal
18.75Single8A6DAll-trans-retinal8A6D-Rhodopsin-All-trans-retinal
18.75Single8A6EAll-trans-retinal8A6E-Rhodopsin-All-trans-retinal
18.75Single8IHKAcifran8IHK-HCA3-Acifran
18.75Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/&β;1/&γ;2
18.75Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/&β;1/&γ;2
18.75Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
18.75Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
18.75Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
18.52Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/&β;1/&γ;2
18.52Single7QBIAlpha-factor mating pheromone7QBI-STE2-Alpha-factor mating pheromone
18.52Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2
18.52Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.52Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/&β;1/&γ;2
18.52Consensusclass-d_onOrthosteric Ligandste2_on
18.52Consensusgi_neuromedinOrthosteric Ligand7XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
18.18Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
18.18Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/&β;1/&γ;2
18.18Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/&β;1/&γ;2
18.18Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/&β;1/&γ;2
18.18Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
18.18Single8XZFWN5618XZF-Apelin-WN561-Gi1/&β;1/&γ;2
18.18Consensusclass-d_offOrthosteric Ligandste2_off
18.18Consensusmc4_onOrthosteric Ligand7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
18.18Consensuspth_onOrthosteric Ligandpth1_on pth2_on
18.18Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
17.86Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
17.86Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
17.86Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
17.86Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
17.86Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/&β;1/&γ;2
17.86Consensusccr8_onOrthosteric Ligand8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
17.86Consensusgi_class-dOrthosteric Ligandgi_ste
17.86Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
17.86Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
17.86Consensusgs_cgrpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
17.65Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
17.65Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
17.65Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/&β;1/&γ;2
17.65Single6ZG9GSK10347026ZG9-M1-GSK1034702
17.65Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
17.65Single7XOVSR1461317XOV-CCKA-SR146131-Gs/&β;1/&γ;2
17.65Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
17.65Single8HQN9(S)-HODE8HQN-GPR132-9(S)-HODE-Gi1/&β;1/&γ;2
17.65Single8K4NVF08K4N-GPR34-VF0-Gi1/&β;1/&γ;2
17.65Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/&β;1/&γ;2
17.65Consensuscb1_offOrthosteric Ligand5TGZ-CB1-AM6538 5U09-CB1-Taranabant
17.65Consensusgnrh_offOrthosteric Ligandgnrh1_off
17.39Single4XT1Fractalkine4XT1-US28-Fractalkine
17.39Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
17.39Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2
17.39Single7QA8Peptide7QA8-STE2-Peptide
17.39Single7QA8Peptide7QA8-STE2-Peptide
17.39Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/&β;1/&γ;2
17.39Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/&β;1/&γ;2
17.39Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/&β;1/&γ;2
17.39Consensusclass-d_offOrthosteric Ligandste2_off
17.39Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
17.39Consensusste2_offOrthosteric Ligand7QA8-STE2-Peptide
17.24Single6LMLGlucagon6LML-Glucagon-Glucagon
17.24Single6WZGSecretin6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
17.24Single7D68GLP-27D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
17.24Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2
17.24Single7QBCAlpha-factor mating pheromone7QBC-STE2-Alpha-factor mating pheromone
17.24Single8IY6Endothelin-18IY6-ETB-Endothelin-1
17.24Consensuscrf1_onOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
17.24Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
17.14Single7F16TIP397F16-PTH2-TIP39-Gs/&β;1/&γ;2
17.14Consensusgs_pthOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7F16-PTH2-TIP39-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
16.67Single4A4MAll-trans-retinal4A4M-Rhodopsin-All-trans-retinal-Gt(CT)
16.67Single5EN0All-trans-retinal5EN0-Rhodopsin-All-trans-retinal-Gt(CT)
16.67Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
16.67Single5TGZAM65385TGZ-CB1-AM6538
16.67Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/&β;1/&γ;2
16.67Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
16.67Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
16.67Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
16.67Single6GPSMK08126GPS-CCR2-MK0812
16.67Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
16.67Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/&β;1/&γ;2
16.67Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
16.67Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2
16.67Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/&β;1/&γ;2
16.67Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2
16.67Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
16.67Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2
16.67Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/&β;1/&γ;2
16.67Consensusgs_crfOrthosteric Ligand6P9X-CRF1-Corticoliberin-Gs/&β;1/&γ;2
16.67Consensushca3_onOrthosteric Ligand8IHJ-HCA3-Acifran-Gi1/&β;1/&γ;2
16.67Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491 5ZKP-PAF-Foropafant (SR27417)
16.13Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
16.13Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/&β;1/&γ;2
16.13Single8FLULong-acting PTH8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2
16.13Consensusglp_onOrthosteric Ligandglp1_on glp2_on
16.00Single3OE0CVX153OE0-CXCR4-CVX15
16.00Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
16.00Single7F4DAlpha-MSH7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2
16.00Single7O7F(6P4)CCL57O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1
16.00Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/&β;1/&γ;2
16.00Single8XZHMM078XZH-Apelin-MM07-Gi1/&β;1/&γ;2
16.00Consensusgo_peptideOrthosteric Ligandgo_opioid go_ghrelin go_compl-peptide go_galanin go_vasopressin
16.00Consensusmc5_onOrthosteric Ligand8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
15.79Single6GPXMK08126GPX-CCR2-MK0812
15.79Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/&β;1/&γ;2
15.79Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/&β;1/&γ;2
15.79Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
15.79Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2
15.79Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/&β;1/&γ;2; MRAP1
15.79Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
15.79Consensusgs_class-b1Orthosteric Ligandgs_glucagon gs_vip-pacap gs_pth gs_calcitonin gs_crf
15.79Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/&β;1/&γ;2 7YJ4-RXFP4-INSL5-Gi2/&β;1/&γ;2 7YK6-RXFP4-PubChem 138319674-Gi2/&β;1/&γ;2
15.62Single7VVMPTH7VVM-PTH1-PTH-Gs/&β;1/&γ;2
15.62Single8U1UCCL18U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
15.38Single6M1IPACAP6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
15.38Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
15.38Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
15.38Single7AD3Alpha-factor mating pheromone7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
15.38Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
15.38Single8XZJWN3538XZJ-Apelin-WN353-Gi1/&β;1/&γ;2
15.38Consensusclass-c_onOther Ligandgabab_on mglu_on
15.38Consensusclass-d_onOrthosteric Ligandste2_on
15.38Consensusgi_class-dOrthosteric Ligandgi_ste
15.38Consensusgi_steOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
15.38Consensusgo_class-bOrthosteric Ligandgo_class-b1 go_class-b2
15.38Consensusnmur2_onOrthosteric Ligand7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.38Consensusnmur_onOrthosteric Ligandnmur1_on nmur2_on
15.38Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
15.15Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2
15.15Single8FLQPTH8FLQ-PTH1-PTH-Gs/&β;1/&γ;2
15.15Consensusgs_vip-pacapOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6M1I-PAC1-PACAP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
15.00Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
15.00Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
15.00Single7P2L4YI7P2L-mGlu5-4YI
15.00Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/&β;1/&γ;2
15.00Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/&β;1/&γ;2
15.00Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
15.00Single8X79MRE-2698X79-I2-MRE-269-Gs/&β;1/&γ;2
15.00Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
15.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
14.81Single6X18GLP-16X18-GLP-1-GLP-1-Gs/&β;1/&γ;2
14.81Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/&β;1/&γ;2
14.81Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/&β;1/&γ;2
14.81Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/&β;1/&γ;2
14.81Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/&β;1/&γ;2
14.81Consensusgs_ghrelinOrthosteric Ligand7F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.81Consensusgs_melanocortinOrthosteric Ligand7F4D-MC1-Alpha-MSH-chim(NtGi1-Gs)/&β;1/&γ;2 7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/&β;1/&γ;2 7F54-MC4-Afamelanotide-Gs/&β;1/&γ;2 7F53-MC4-Alpha-MSH-Gs/&β;1/&γ;2 7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2 7PIV-MC4-Setmelanotide-Gs/&β;1/&γ;2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/&β;1/&γ;2 7F58-MC4-THIQ-Gs/&β;1/&γ;2
14.81Consensusgs_neuromedinOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
14.71Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
14.71Consensusgs_class-bOrthosteric Ligandgs_class-b1 gs_class-b2
14.29Single2HPYAll-trans-retinal2HPY-Rhodopsin-All-trans-retinal
14.29Single4XT3Fractalkine4XT3-US28-Fractalkine
14.29Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
14.29Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
14.29Single6FJ3PTH6FJ3-PTH1-PTH
14.29Single6KPGAM8416KPG-CB1-AM841-Gi1/&β;1/&γ;2
14.29Single6NBFLong-acting PTH analog6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
14.29Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/&β;1/&γ;2
14.29Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
14.29Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
14.29Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
14.29Single7D3SSecretin7D3S-Secretin-Secretin-Gs/&β;1/&γ;2
14.29Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/&β;1/&γ;2
14.29Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
14.29Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2
14.29Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single7W0NElabela7W0N-Apelin-Elabela-Gi1/&β;1/&γ;2
14.29Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/&β;1/&γ;2
14.29Single8GCPPGE28GCP-EP4-PGE2-Gi1/&β;1/&γ;2
14.29Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2
14.29Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/&β;1/&γ;2
14.29Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2
14.29Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/&β;1/&γ;2
14.29Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
14.29Consensusgi_prostanoidOrthosteric Ligand8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GDC-EP3-PGE2-Gi1/&β;1/&γ;2 8GCM-EP4-L902688-Gi1/&β;1/&γ;2
14.29Consensusprostanoid_onOrthosteric Ligandep_on fpa_on
13.79Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/&β;1/&γ;2; RAMP3
13.79Single7DTYGIP7DTY-GIP-GIP-Gs/&β;1/&γ;2
13.79Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2
13.79Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
13.79Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2
13.79Consensusste2_onOrthosteric Ligand7AD3-STE2-Alpha-factor mating pheromone-Gi1/STE4/&γ;2
13.64Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
13.64Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
13.64Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
13.64Single7P00Substance P7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Single7X8RBOC57X8R-GLP-1-BOC5-Gs/&β;1/&γ;2
13.64Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
13.64Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.64Consensusc5a1_off_ortoalloOrthosteric Ligand6C1Q-C5a1-PMX53-NDT9513727 6C1R-C5a1-PMX53-Avacopan; Na
13.64Consensuscyslt2_offOrthosteric Ligand6RZ6-CysLT2-ONO-2570366 6RZ9-CysLT2-ONO-2770372 6RZ8-CysLT2-ONO-2080365
13.64Consensuscyslt_offOrthosteric Ligandcyslt2_off
13.64Consensusep4_onOrthosteric Ligand7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 8GCP-EP4-PGE2-Gi1/&β;1/&γ;2 8GD9-EP4-Rivenprost-Gs/&β;1/&γ;2 8GDA-EP4-L902688-Gs/&β;1/&γ;2
13.64Consensusgs_lipidOrthosteric Ligandgs_ffa gs_prostanoid
13.64Consensusgs_prostanoidOrthosteric Ligand8IUK-FP-alpha-PGF2-alpha-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2 7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1 7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.51Consensusclass-b1_onOrthosteric Ligandglucagon_on calcitonin_on vip-pacap_on pth_on crf_on
13.33Single3OE6IT1t3OE6-CXCR4-IT1t
13.33Single3OE8IT1t3OE8-CXCR4-IT1t
13.33Single6NBHLong-acting PTH analog6NBH-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
13.33Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP3
13.33Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/&β;1/&γ;2
13.33Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/&β;1/&γ;2
13.33Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/&β;1/&γ;2
13.33Consensusgi_chemokineOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2 7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2 7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2 7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2 8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2 6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2 8U1U-CCR8-CCL1-Gi1/&β;1/&γ;2
13.33Consensusgip_on_alloOther Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
13.16Consensusgs_calcitoninOrthosteric Ligandgs_ct gs_cgrp
13.04Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
13.04Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/&β;1/&γ;2
13.04Single7RMGSubstance P7RMG-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
13.04Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
13.04Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Single8SAI1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine8SAI-GPR34-1-oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine-Gi1/&β;1/&γ;2
13.04Consensuschemokine_onOrthosteric Ligandcxcr_on cx3cr_on
13.04Consensusgo_ghrelinOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2
13.04Consensusgs_adgrOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
13.04Consensusgs_class-b2Orthosteric Ligandgs_adgr
13.04Consensusnk1_onOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
13.04Consensusprotein_onOrthosteric Ligandccr_on chemokine_on gphr_on chemerin_on
12.50Single5VBLApelin Mimetic Peptide Agonist5VBL-Apelin-Apelin Mimetic Peptide Agonist
12.50Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
12.50Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
12.50Single7RMHSubstance P7RMH-NK1-Substance P-Gs/&β;1/&γ;2
12.50Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/&β;1/&γ;2
12.50Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
12.50Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/&β;1/&γ;2
12.50Single8JILNiacin8JIL-HCA2-Niacin-Gi1/&β;1/&γ;2
12.50Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
12.50Single8X2K5YM8X2K-GPR3-5YM-chim(NtGi1-Gs)/&β;1/&γ;2
12.50Consensusclass-t_onOrthosteric Ligandtaste2_on
12.50Consensusgo_adhesionOrthosteric Ligand7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2 7D76-ADGRG3-Beclomethasone-Go/&β;1/&γ;2
12.50Consensusgo_class-b2Orthosteric Ligandgo_adhesion
12.50Consensusgs_class-tOrthosteric Ligandgs_taste
12.50Consensusgs_tasteOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
12.50Consensusnmur1_onOrthosteric Ligand7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.50Consensusprotein_offOrthosteric Ligandccr_off chemokine_off gnrh_off
12.50Consensustaste2_onOrthosteric Ligand7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/&β;1/&γ;2
12.12Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2
12.12Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2
12.12Consensuspth1_onOrthosteric Ligand8FLQ-PTH1-PTH-Gs/&β;1/&γ;2 8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2 7Y36-PTH1-Teriparatide-Gs/&β;1/&γ;2 7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2 8FLU-PTH1-Long-acting PTH-Gs/&β;1/&γ;2 6NBF-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2 7VVM-PTH1-PTH-Gs/&β;1/&γ;2
12.12Consensusvip-pacap_onOrthosteric Ligandvpac1_on vpac2_on pca1_on
12.00Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
12.00Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
12.00Single7RMISubstance P7RMI-NK1-Substance P-chim(Gs-CtGq)/&β;1/&γ;2
12.00Single7SK5CXCL127SK5-ACKR3-CXCL12
12.00Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
12.00Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
12.00Consensuscx3cr_onOrthosteric Ligandcx3cr1_on
12.00Consensussst_offOrthosteric Ligandsst2_off
11.76Single3ODUIT1t3ODU-CXCR4-IT1t
11.76Single5U09Taranabant5U09-CB1-Taranabant
11.76Single5ZKQABT-4915ZKQ-PAF-ABT-491
11.76Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
11.76Single7F8YDevazepide7F8Y-CCKA-Devazepide
11.76Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
11.76Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/&β;1/&γ;2
11.76Single8U8FPML8U8F-GPR3-PML-Gs/&β;1/&γ;2
11.76Consensusgs_glucagonOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 6WZG-Secretin-Secretin-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2 7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2 7DTY-GIP-GIP-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
11.76Consensusp2y_offOrthosteric Ligandp2y1_off p2y12_off
11.76Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/&β;1/&γ;2
11.54Single7VVNPTH7VVN-PTH1-PTH-Gs/&β;1/&γ;2
11.54Single7XA3CCL27XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
11.54Single7XNACYN1548067XNA-SST2-CYN154806
11.54Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/&β;1/&γ;2
11.54Consensuscx3cr1_onOrthosteric Ligand7XBX-CX3CR1-CX3CL1-Gi1/&β;1/&γ;2
11.54Consensusgs_motilinOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Consensusgs_tachykininOrthosteric Ligand8U26-NK1-Protachykinin-1-Gs/&β;1/&γ;2 7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7P00-NK1-Substance P-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
11.54Consensusmc3_onOrthosteric Ligand8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
11.54Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
11.54Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on
11.43Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2
11.11Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
11.11Single6FFIMMPEP6FFI-mGlu5-MMPEP
11.11Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
11.11Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2
11.11Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/&β;1/&γ;2
11.11Single7VVOPTH7VVO-PTH1-PTH-Gs/&β;1/&γ;2
11.11Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/&β;1/&γ;2
11.11Single8GCML9026888GCM-EP4-L902688-Gi1/&β;1/&γ;2
11.11Single8T3VDHA8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
11.11Consensusghrelin_onOrthosteric Ligand7W2Z-Ghrelin-Ghrelin-Go/&β;1/&γ;2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7NA8-Ghrelin-PubChem 178024-Gi1/&β;1/&γ;2
11.11Consensuslh_on_alloOther Ligand7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
11.11Consensuspca1_onOrthosteric Ligand6M1I-PAC1-PACAP-Gs/&β;1/&γ;2
10.81Consensusglucagon_onOrthosteric Ligandgip_on glu_on secretin_on ghrh_on glp_on
10.71Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/&β;1/&γ;2
10.71Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/&β;1/&γ;2
10.71Consensusvpac1_onOrthosteric Ligand8E3Y-VPAC1-PACAP27-Gs/&β;1/&γ;2 8E3Z-VPAC1-VIP-Gs/&β;1/&γ;2 6VN7-VPAC1-PACAP-Gs/&β;1/&γ;2
10.53Single4QIMPubChem 249053754QIM-SMO-PubChem 24905375
10.53Single6FFHFenobam6FFH-mGlu5-Fenobam
10.53Single6IIVDaltroban6IIV-TP-Daltroban
10.53Single7F83PF-051904577F83-Ghrelin-PF-05190457
10.53Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/&β;1/&γ;2
10.53Single8EJCTAK-8758EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.53Single8EJKTAK-8758EJK-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2
10.53Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-alpha-chim(NtGi2-Gs-CtGq)/&β;1/&γ;2
10.53Consensusffa1_onOrthosteric Ligand8EIT-FFA1 (GPR40)-Doconexent-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8EJC-FFA1 (GPR40)-TAK-875-chim(NtGi1L-Gs-CtGq)/&β;1/&γ;2 8T3V-FFA1-DHA-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
10.53Consensushcar_offOrthosteric Ligandsuccinate_off
10.53Consensusprostanoid_offOrthosteric Ligandep_off tp_off dp_off
10.53Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
10.53Consensustp_offOrthosteric Ligand6IIV-TP-Daltroban 6IIU-TP-Ramatroban
10.34Single6NBILong-acting PTH analog6NBI-PTH1-Long-acting PTH analog-Gs/&β;1/&γ;2
10.34Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
10.34Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/&β;1/&γ;2
10.34Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/&β;1/&γ;2
10.34Consensusccr5_onOrthosteric Ligand7O7F-CCR5-(6P4)CCL5-Gi1/&β;1/&γ;1 7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
10.34Consensusglp1_on_alloOrthosteric Ligand6VCB-GLP-1-GLP-1-LSN3160440-Gs/&β;1/&γ;2
10.00Single4PHUFasiglifam4PHU-FFA1 (GPR40)-Fasiglifam
10.00Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
10.00Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
10.00Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
10.00Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
10.00Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
10.00Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
10.00Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
10.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
10.00Single8FN1Neurotensin/neuromedin N8FN1-NTS1-Neurotensin/neuromedin N-chim(NtGi1-Go)/&β;1/&γ;2
10.00Single8GDAL9026888GDA-EP4-L902688-Gs/&β;1/&γ;2
10.00Single8GDCPGE28GDC-EP3-PGE2-Gi1/&β;1/&γ;2
10.00Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
10.00Consensusccr2_off_alloOther Ligand5T1A-CCR2-PubChem 68764898; PubChem 12093170 6GPX-CCR2-MK0812
10.00Consensusccr_onOrthosteric Ligandccr5_on ccr6_on ccr1_on ccr2_on ccr8_on
10.00Consensusclass-c_offOther Ligandgabab_off mglu_off
10.00Consensusep3_onOrthosteric Ligand8GDC-EP3-PGE2-Gi1/&β;1/&γ;2
10.00Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
10.00Consensusep_offOrthosteric Ligandep4_off
9.68Single7VVLPTH7VVL-PTH1-PTH-Gs/&β;1/&γ;2
9.68Consensussecretin_onOrthosteric Ligand6WZG-Secretin-Secretin-Gs/&β;1/&γ;2
9.52Single5TZR-5TZR-FFA1 (GPR40)-MK8666
9.52Single5V56TC1145V56-SMO-TC114
9.52Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
9.52Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/&β;1/&γ;2
9.52Single7F1TMIP-1a7F1T-CCR5-MIP-1a
9.52Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/&β;1/&γ;2
9.52Single8GDBPGE28GDB-EP4-PGE2-Gs/&β;1/&γ;2
9.52Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
9.52Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
9.52Consensusmglu2_onOther Ligand7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/&β;1/&γ;2 7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/&β;1/&γ;2
9.52Consensuss1p2_onOrthosteric Ligand7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
9.38Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
9.09Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
9.09Single4PY02MeSATP4PY0-P2Y12-2MeSATP
9.09Single4XEENeurotensin4XEE-NTS1-Neurotensin
9.09Single4XESNeurotensin4XES-NTS1-Neurotensin
9.09Single5X33BIIL2605X33-BLT1-BIIL260
9.09Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
9.09Single6IIURamatroban6IIU-TP-Ramatroban
9.09Single6OS2TRV0266OS2-AT1-TRV026
9.09Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/&β;1/γ1
9.09Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
9.09Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/&β;1/&γ;2
9.09Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2
9.09Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/&β;1/&γ;2
9.09Single8IBUErythromycin A8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
9.09Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
9.09Consensusep_onOrthosteric Ligandep4_on ep2_on ep3_on
9.09Consensusnts1_offOrthosteric Ligand6Z4Q-NTS1-SR142948A 6Z4S-NTS1-SR48692
9.09Consensusnts_offOrthosteric Ligandnts1_off
8.70Single4BUONeurotensin4BUO-NTS1-Neurotensin
8.70Consensusadgrg2_onOrthosteric Ligand7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2 7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/&β;1/&γ;2
8.57Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2
8.33Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
8.33Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/&β;1/&γ;2
8.33Single8INRAlpha-MSH8INR-MC5-Alpha-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
8.33Consensusmotilin_onOrthosteric Ligand8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 8IBU-Motilin-Erythromycin A-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
8.00Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/&β;1/&γ;2
8.00Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/&β;1/&γ;1
8.00Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2
8.00Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/&β;1/&γ;2
7.69Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/&β;1/&γ;2
7.69Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/&β;1/&γ;2
7.69Single7SHEPI; PE7SHE-GPR158-PI; PE
7.69Single8IOCGamma-MSH8IOC-MC3-Gamma-MSH-Ca-chim(NtGi1-Gs)/&β;1/&γ;2
7.69Consensusglu_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2 6WPW-Glucagon-Glucagon derivative ZP3780-Gs/&β;1/&γ;2 8JIT-Glucagon-MEDI0382-Gs/&β;1/&γ;2 8JIQ-Glucagon-Peptide-15-Gs/&β;1/&γ;2 7V35-Glucagon-Peptide-20-Gs/&β;1/&γ;2 8JIU-Glucagon-SAR425899-Gs/&β;1/&γ;2 6WHC-Glucagon-Glu16 analog of GCG-Gs/&β;1/&γ;2
7.41Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
7.41Consensusccr_offOrthosteric Ligandccr5_off ccr8_off
7.14Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
7.14Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
7.14Single7XKEBetahydroxyandrosterone7XKE-ADGRG2-Betahydroxyandrosterone-chim(NtGi1-Gs)/&β;1/&γ;2
7.14Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/&β;1/&γ;2
7.14Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/&β;1/&γ;2
7.14Consensusccr1_onOrthosteric Ligand7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
6.90Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/&β;1/&γ;2
6.67Single7SK3CXCL127SK3-ACKR3-CXCL12
6.67Single7VDMSubstance P7VDM-MRGPRX2-Substance P-Gi1/&β;1/&γ;2
6.67Single7XKDBetahydroxyandrosterone7XKD-ADGRG2-Betahydroxyandrosterone-Gs/&β;1/&γ;2
6.67Single7Y14Beta-alanine7Y14-MRGPRD-Beta-alanine
6.67Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/&β;1/&γ;2
6.67Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1 6UUN-CT Like (AM1)-Adrenomedullin-Gs/&β;1/&γ;2; RAMP2
6.67Consensusghrh_onOrthosteric Ligand7CZ5-GHRH-Somatoliberin-Gs/&β;1/&γ;2
6.45Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
6.45Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/&β;1/&γ;2
6.45Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
6.45Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/&β;1/&γ;2
6.25Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
6.25Single6LI0GTPL98046LI0-GPR52-GTPL9804
6.25Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/&β;1/&γ;2
6.25Single7S8O(R)-Zinc-35737S8O-MRGPRX2-(R)-Zinc-3573-Gi1/&β;1/&γ;2
6.25Single7VVKPTH7VVK-PTH1-PTH-Gs/&β;1/&γ;2
6.25Single7Y12Beta-alanine7Y12-MRGPRD-Beta-alanine-Gi1/&β;1/&γ;2
6.25Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/&β;1/&γ;2
6.25Consensuscalcitonin_onOrthosteric Ligandct_on ctlike_on
6.25Consensusglp1_onOrthosteric Ligand6X18-GLP-1-GLP-1-Gs/&β;1/&γ;2 6X19-GLP-1-CHU-128-Gs/&β;1/&γ;2 6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2 7S1M-GLP-1-Ex4-D-Ala-Gs/&β;1/&γ;2 7LLL-GLP-1-Exendin-4-Gs/&β;1/&γ;2 6B3J-GLP-1-Exendin-P5-Gs/&β;1/&γ;2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/&β;1/&γ;2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/&β;1/&γ;2 6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/&β;1/&γ;2 7RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2 7VBH-GLP-1-Peptide-20-Gs/&β;1/&γ;2 7C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2 8JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2 7KI0-GLP-1-Semaglutide-Gs/&β;1/&γ;2 7KI1-GLP-1-Taspoglutide-Gs/&β;1/&γ;2 7FIM-GLP-1-Tirzepatide-Gs/&β;1/&γ;2
6.25Consensussmo_off_alloOrthosteric Ligand6D32-SMO-Cyclopamine-Cyclopamine
6.25Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/&β;1/&γ;2
6.06Consensusgip_onOrthosteric Ligand7DTY-GIP-GIP-Gs/&β;1/&γ;2 7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/&β;1/&γ;2 7FIN-GIP-Peptide-20; GGL-Gs/&β;1/&γ;2 7FIY-GIP-Tirzepatide-Gs/&β;1/&γ;2
6.06Consensusgip_on_alloOrthosteric Ligand7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/&β;1/&γ;2
5.88Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
5.88Single5L7IVismodegib5L7I-SMO-Vismodegib
5.88Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
5.88Single7S8N(R)-Zinc-35737S8N-MRGPRX2-(R)-Zinc-3573-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.88Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2
5.88Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
5.88Consensusm4_on_alloOther Ligand7TRP-M4-Iperoxo-LY2033298-Gi1/&β;1/&γ;2 7TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2 7V68-M4-Iperoxo-PubChem 57664406-Gi1/&β;1/&γ;2
5.88Consensussmo_on_alloOrthosteric Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.71Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/&β;1/&γ;2
5.56Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
5.56Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
5.56Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2
5.56Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/&β;1/&γ;2
5.56Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/&β;1/&γ;2
5.56Single8FN0Neurotensin/neuromedin N8FN0-NTS1-Neurotensin/neuromedin N-PubChem 118610427-chim(NtGi1-Go)/&β;1/&γ;2
5.56Single8HMPPubChem 699214798HMP-GPR52-PubChem 69921479-Gs/&β;1/&γ;2
5.56Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
5.56Consensusm2_on_alloOther Ligand7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/&β;1/&γ;2 6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/&β;1/&γ;2
5.56Consensussmo_on_alloOther Ligand6XBL-SMO-SAG-Cholesterol-Gi1/&β;1/&γ;2
5.26Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
5.26Single6ZINSR486926ZIN-NTS1-SR48692
5.26Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/&β;1/&γ;2
5.26Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
5.26Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/&β;1/&γ;2
5.26Single7VV6C48/807VV6-MRGPRX2-C48/80
5.26Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
5.26Single8IYXYL-3658IYX-GPR34-YL-365
5.26Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/&β;1/&γ;2
5.26Single8K2WAMG4878K2W-CXCR3-AMG487
5.26Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/&β;1/&γ;2
5.26Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/&β;1/&γ;2
5.26Consensuscxcr_onOrthosteric Ligandcxcr1_on cxcr2_on
5.26Consensusm1_off_alloOther Ligand6WJC-M1-Atropine-Muscarinic toxin 7
5.00Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/&β;1/&γ;2
5.00Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
5.00Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/&β;1/&γ;2
5.00Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
5.00Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/&β;1/&γ;2
5.00Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/&β;1/&γ;2
5.00Consensussmo_offOrthosteric Ligand5L7I-SMO-Vismodegib 4O9R-SMO-Cyclopamine 4QIM-SMO-PubChem 24905375 4JKV-SMO-Taladegib (LY2940680)
4.76Single4JKVTaladegib (LY2940680)4JKV-SMO-Taladegib (LY2940680)
4.76Single6Z4SSR486926Z4S-NTS1-SR48692
4.76Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
4.76Single8JPCNeurotensin 8-138JPC-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
4.55Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
4.55Single4BV0Neurotensin4BV0-NTS1-Neurotensin
4.55Single5V57TC1145V57-SMO-TC114
4.55Single6OS1TRV0266OS1-AT1-TRV026
4.55Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
4.55Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1
4.55Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/&β;1/&γ;1
4.55Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55Single8FMZNeurotensin/neuromedin N8FMZ-NTS1-Neurotensin/neuromedin N-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.55Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/&β;1/&γ;2
4.55Consensusnts1_on_alloOrthosteric Ligand8JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
4.35Single4GRVNeurotensin 8-134GRV-NTS1-Neurotensin 8-13
4.35Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/&β;1/&γ;2
4.35Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/&β;1/&γ;2
4.35Single6YVRNTS8-136YVR-NTS1-NTS8-13
4.35Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/&β;1/&γ;1
4.35Single7SHEPI; PE7SHE-GPR158-PI; PE
4.35Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2
4.35Single8JPBNeurotensin 8-138JPB-NTS1-Neurotensin 8-13-PubChem 118610427; GDP; Mg-Gq; GRK2
4.35Consensuschemokine_offOrthosteric Ligandcxcr_off
4.35Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II
4.35Consensuscxcr_offOrthosteric Ligandcxcr4_off
4.35Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
4.35Consensusnts1_onOrthosteric Ligand6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
4.35Consensusnts_onOrthosteric Ligandnts1_on
4.17Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
4.17Single5TZYMK8666; PubChem 1270535975TZY-FFA1 (GPR40)-MK8666; PubChem 127053597
4.17Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/&β;1/&γ;2
4.17Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
4.17Single7CX2PGE27CX2-EP2-PGE2-Gs/&β;1/&γ;2
4.17Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2
4.17Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
4.17Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
4.17Consensusep2_onOrthosteric Ligand7CX4-EP2-Evatanepag-Gs/&β;1/&γ;2 7CX2-EP2-PGE2-Gs/&β;1/&γ;2 7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
4.17Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.17Consensusgi_neurotensinOrthosteric Ligand7L0P-NTS1-Neurotensin-Gi1/&β;1/&γ;1 6OS9-NTS1-JMV449-Gi1/&β;1/&γ;2
4.17Consensusgs_galaninOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/&β;1/&γ;2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
4.00Single6KNMJN241-96KNM-Apelin-JN241-9
3.85Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/&β;1/&γ;2
3.85Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/&β;1/&γ;2
3.70Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
3.70Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2
3.03Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP1
2.94Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/&β;1/&γ;2; RAMP1
2.94Single7TYIAmylin7TYI-CT-Amylin-Gs/&β;1/&γ;2
2.94Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2
2.86Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.78Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/&β;1/&γ;2; RAMP3
2.78Single8F0KPramlintide analogue san3858F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.70Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/&β;1/&γ;2; RAMP2
2.70Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/&β;1/&γ;2; RAMP1
2.56Single8F2APramlintide analogue san3858F2A-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.56Consensusct_onOrthosteric Ligand7TYL-CT-Amylin-Gs/&β;1/&γ;2 7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2
2.44Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/&β;1/&γ;2
2.38Single8F2BPramlintide analogue san458F2B-CT (AMY3)-Pramlintide analogue san45-Gs/&β;1/&γ;2; RAMP3
2.38Consensusgs_ctOrthosteric Ligand7TYN-CT-Calcitonin-1-Gs/&β;1/&γ;2 6NIY-CT-Adrenomedullin-Gs/&β;1/&γ;2 8F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2 7TYL-CT-Amylin-Gs/&β;1/&γ;2 8F0K-CT (AMY3)-Pramlintide analogue san385-Gs/&β;1/&γ;2; RAMP3
2.27Single8F0JPramlintide analogue san458F0J-CT-Pramlintide analogue san45-Gs/&β;1/&γ;2

PDB Summary
PDB 6PS5
Class A
SubFamily Amine
Type Adrenergic
SubType Beta2
Species Homo sapiens
Ligand (S)-Propranolol
Other Ligand(s) -
Protein Partners -
PDB Resolution 2.9
Date 2019-11-13
D.O.I. 10.1107/S2052252519013137
Net Summary
Imin 3.64
Number of Linked Nodes 262
Number of Links 285
Number of Hubs 34
Number of Links mediated by Hubs 139
Number of Communities 5
Number of Nodes involved in Communities 36
Number of Links involved in Communities 48
Path Summary
Number Of Nodes in MetaPath 55
Number Of Links MetaPath 54
Number of Shortest Paths 38425
Length Of Smallest Path 3
Average Path Length 12.3353
Length of Longest Path 26
Minimum Path Strength 1.26
Average Path Strength 6.74784
Maximum Path Strength 27.38
Minimum Path Correlation 0.7
Average Path Correlation 0.920953
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 4.54545
Average % Of Corr. Nodes 49.503
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 41.7623
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeSNP
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeSNP
NameDexpropranolol
SynonymsR-(+)-Propranolol
Identifier(2S)-1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol
FormulaC16 H21 N O2
Molecular Weight259.343
SMILESCC(C)NC[C@@H](COc1cccc2c1cccc2)O
PubChem91536
Formal Charge0
Total Atoms40
Total Chiral Atoms1
Total Bonds41
Total Aromatic Bonds11

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP07550
Sequence
>6PS5_Chain_R
DEVWVVGMG IVMSLIVLA IVFGNVLVI TAIAKFERL QTVTNYFIT 
SLACADLVM GLAVVPFGA AHILMKMWT FGNFWCEFW TSIDVLCVT 
ASIWTLCVI AVDRYFAIT SPFKYQSLL TKNKARVII LMVWIVSGL 
TSFLPIQMH WYRATHQEA INCYAEETC CDFFTNQAY AIASSIVSF 
YVPLVIMVF VYSRVFQEA KRQLKFCLK EHKALKTLG IIMGTFTLC 
WLPFFIVNI VHVIQDNLI RKEVYILLN WIGYVNSGF NPLIYCRSP 
DFRIAFQEL LCL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  



This network is also present in following consensuses:
IdComponents
beta2_off6PS2-β2-(S)-Alprenolol
6PS3-β2-(S)-Carvedilol
6PS5-β2-(S)-Propranolol
6PS6-β2-Timolol
2RH1-β2-(S)-Carazolol
6PS4-β2-ICI 118-551
3NY9-β2-PubChem 913103

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
2R4RAAmineAdrenergicβ2Homo sapiens---3.42007-11-0610.1038/nature06325
2R4SAAmineAdrenergicβ2Homo sapiens---3.42007-11-0610.1038/nature06325
2RH1AAmineAdrenergicβ2Homo sapiens(S)-Carazolol--2.42007-10-3010.1126/science.1150577
3D4SAAmineAdrenergicβ2Homo sapiensTimolol Maleate--2.82008-06-1710.1016/j.str.2008.05.001
3KJ6AAmineAdrenergicβ2Homo sapiens---3.42010-02-1610.1038/nature08650
3NY8AAmineAdrenergicβ2Homo sapiensICI 118-551--2.842010-08-1110.1021/ja105108q
3NY9AAmineAdrenergicβ2Homo sapiensPubChem 913103--2.842010-08-1110.1021/ja105108q
3NYAAAmineAdrenergicβ2Homo sapiens(S)-Alprenolol--3.162010-08-1110.1021/ja105108q
3P0GAAmineAdrenergicβ2Homo sapiensBI167107--3.52011-01-1910.1038/nature09648
3PDSAAmineAdrenergicβ2Homo sapiensHydroxybenzylisoproterenol--3.52011-01-1210.1038/nature09665
3SN6AAmineAdrenergicβ2Homo sapiensBI167107-Gs/&β;1/&γ;23.22011-07-2010.1038/nature10361
4GBRAAmineAdrenergicβ2Homo sapiens(S)-Carazolol--3.992012-10-2410.1371/journal.pone.0046039
4LDEAAmineAdrenergicβ2Homo sapiensBI167107--2.792013-09-2510.1038/nature12572
4LDLAAmineAdrenergicβ2Homo sapiensHydroxybenzylisoproterenol--3.12013-09-2510.1038/nature12572
4LDOAAmineAdrenergicβ2Homo sapiensL-Epinephrine--3.22013-09-2510.1038/nature12572
4QKXAAmineAdrenergicβ2Homo sapiensPubChem 76210628--3.32014-07-2310.1073/pnas.1410415111
5D5AAAmineAdrenergicβ2Homo sapiens(S)-Carazolol--2.482016-01-1310.1107/S2059798315021683
5D5BAAmineAdrenergicβ2Homo sapiens(S)-Carazolol--3.82016-01-1310.1107/S2059798315021683
5D6LAAmineAdrenergicβ2Homo sapiens(S)-Carazolol--3.22016-08-1710.1038/nprot.2017.057
5JQHAAmineAdrenergicβ2Homo sapiens(S)-Carazolol--3.22016-07-1310.1038/nature18636
5X7DAAmineAdrenergicβ2Homo sapiens(S)-CarazololPubChem 129318963-2.72017-08-1610.1038/nature23652
6E67AAmineAdrenergicβ2Homo sapiensBI167107-Gs (fused)3.72019-06-0510.1016/j.cell.2019.04.021
6MXTAAmineAdrenergicβ2Homo sapiensSalmeterol--2.962018-11-1410.1038/s41589-018-0145-x
6N48AAmineAdrenergicβ2Homo sapiensBI167107PubChem 138454256-3.22019-06-2610.1126/science.aaw8981
6NI3AAmineAdrenergicβ2Homo sapiensBI167107-Gs/&β;1/&γ;23.82019-11-2010.1038/s41594-019-0330-y
6OBAAAmineAdrenergicβ2Homo sapiens(S)-AlprenololGTPL11074-3.12020-03-2510.1038/s41589-020-0549-2
6PRZAAmineAdrenergicβ2Homo sapiens(S)-Alprenolol--2.82019-11-1310.1107/S2052252519013137
6PS0AAmineAdrenergicβ2Homo sapiens(S)-Carazolol--3.42019-11-1310.1107/S2052252519013137
6PS1AAmineAdrenergicβ2Homo sapiensTimolol--3.22019-11-1310.1107/S2052252519013137
6PS2AAmineAdrenergicβ2Homo sapiens(S)-Alprenolol--2.42019-11-1310.1107/S2052252519013137
6PS3AAmineAdrenergicβ2Homo sapiens(S)-Carvedilol--2.52019-11-1310.1107/S2052252519013137
6PS4AAmineAdrenergicβ2Homo sapiensICI 118-551--2.62019-11-1310.1107/S2052252519013137
6PS6AAmineAdrenergicβ2Homo sapiensTimolol--2.72019-11-1310.1107/S2052252519013137
7BZ2AAmineAdrenergicβ2Homo sapiensArformoterol-Gs/&β;1/&γ;23.822020-08-0510.1038/s41421-020-0176-9
7DHIAAmineAdrenergicβ2Homo sapiensSalbutamol-Gs/&β;1/&γ;23.262020-12-1610.1093/nsr/nwaa284
7DHRAAmineAdrenergicβ2Homo sapiensIsoprenaline-Gs/&β;1/&γ;23.82020-12-1610.1093/nsr/nwaa284
7XKAAAmineAdrenergicβ2Homo sapiensEpinephrine--3.12023-04-2610.1038/s41467-023-37808-y
8GDZAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GE1AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GE3AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8GE4AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8GE6AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GE7AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GE8AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GE9AAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GEAAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GEBAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8GECAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GEDAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GEEAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.72024-03-0610.1038/s41586-024-07153-1
8GEFAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.82024-03-0610.1038/s41586-024-07153-1
8GEGAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;23.82024-03-0610.1038/s41586-024-07153-1
8GEHAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;242024-03-0610.1038/s41586-024-07153-1
8GEIAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;24.12024-03-0610.1038/s41586-024-07153-1
8GEJAAmineAdrenergicβ2Homo sapiensEpinephrine-Gs/&β;1/&γ;24.22024-03-0610.1038/s41586-024-07153-1
8GFVAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.12024-03-0610.1038/s41586-024-07153-1
8GFWAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GFXAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GFYAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GFZAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GG0AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;22.92024-03-0610.1038/s41586-024-07153-1
8GG1AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GG2AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;232024-03-0610.1038/s41586-024-07153-1
8GG3AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.12024-03-0610.1038/s41586-024-07153-1
8GG4AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.22024-03-0610.1038/s41586-024-07153-1
8GG5AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.22024-03-0610.1038/s41586-024-07153-1
8GG6AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8GG7AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8GG8AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8GG9AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GGAAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GGBAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GGCAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8GGEAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8GGFAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8GGIAAmineAdrenergicβ2Homo sapiensEpinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGJAAmineAdrenergicβ2Homo sapiensEpinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGKAAmineAdrenergicβ2Homo sapiensEpinephrine--3.32024-03-0610.1038/s41586-024-07153-1
8GGLAAmineAdrenergicβ2Homo sapiensEpinephrine--3.22024-03-0610.1038/s41586-024-07153-1
8GGMAAmineAdrenergicβ2Homo sapiensEpinephrine--3.22024-03-0610.1038/s41586-024-07153-1
8GGNAAmineAdrenergicβ2Homo sapiensEpinephrine--3.32024-03-0610.1038/s41586-024-07153-1
8GGOAAmineAdrenergicβ2Homo sapiensEpinephrine--3.22024-03-0610.1038/s41586-024-07153-1
8GGPAAmineAdrenergicβ2Homo sapiensEpinephrine--3.22024-03-0610.1038/s41586-024-07153-1
8GGQAAmineAdrenergicβ2Homo sapiensEpinephrine--3.42024-03-0610.1038/s41586-024-07153-1
8GGRAAmineAdrenergicβ2Homo sapiensEpinephrine--3.42024-03-0610.1038/s41586-024-07153-1
8GGSAAmineAdrenergicβ2Homo sapiensEpinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGTAAmineAdrenergicβ2Homo sapiensEpinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGUAAmineAdrenergicβ2Homo sapiensEpinephrine--3.42024-03-0610.1038/s41586-024-07153-1
8GGVAAmineAdrenergicβ2Homo sapiensEpinephrine--3.52024-03-0610.1038/s41586-024-07153-1
8GGWAAmineAdrenergicβ2Homo sapiensEpinephrine--3.62024-03-0610.1038/s41586-024-07153-1
8GGXAAmineAdrenergicβ2Homo sapiensEpinephrine--3.62024-03-0610.1038/s41586-024-07153-1
8GGYAAmineAdrenergicβ2Homo sapiensEpinephrine--3.92024-03-0610.1038/s41586-024-07153-1
8GGZAAmineAdrenergicβ2Homo sapiensEpinephrine--3.92024-03-0610.1038/s41586-024-07153-1
8GH0AAmineAdrenergicβ2Homo sapiensEpinephrine--42024-03-0610.1038/s41586-024-07153-1
8GH1AAmineAdrenergicβ2Homo sapiensEpinephrine--4.12024-03-0610.1038/s41586-024-07153-1
8JJ8AAmineAdrenergicβ2Homo sapiensFormoterol--3.22023-09-0610.1038/s41589-023-01389-0
8JJLAAmineAdrenergicβ2Homo sapiensOlodaterol--3.22023-09-0610.1038/s41589-023-01389-0
8JJOAAmineAdrenergicβ2Homo sapiensAlprenolol--3.42023-09-0610.1038/s41589-023-01389-0
8UNLAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8UNMAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNNAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNOAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8UNPAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8UNQAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8UNRAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNSAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNTAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNUAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8UNVAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.32024-03-0610.1038/s41586-024-07153-1
8UNWAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.42024-03-0610.1038/s41586-024-07153-1
8UNXAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8UNYAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8UNZAAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.82024-03-0610.1038/s41586-024-07153-1
8UO0AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8UO1AAmineAdrenergicβ2Homo sapiensEpinephrineGTP; MgGs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8UO2AAmineAdrenergicβ2Homo sapiensEpinephrineGTPGs/&β;1/&γ;23.62024-03-0610.1038/s41586-024-07153-1
8UO3AAmineAdrenergicβ2Homo sapiensEpinephrineGTP; MgGs/&β;1/&γ;23.52024-03-0610.1038/s41586-024-07153-1
8UO4AAmineAdrenergicβ2Homo sapiensEpinephrineGTP; MgGs/&β;1/&γ;242024-03-0610.1038/s41586-024-07153-1




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