psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:V89	13.71	Yes	No	0	0	4
2	L:L:?1	R:R:S92	7.54	Yes	No	1	0	6
3	L:L:?1	R:R:T93	3.7	Yes	No	1	0	6
4	L:L:?1	R:R:F167	3.06	Yes	No	0	0	4
5	L:L:?1	R:R:S177	5.03	Yes	No	1	0	5
6	L:L:?1	R:R:S181	7.54	Yes	No	1	0	6
7	L:L:?1	R:R:W248	3.81	Yes	Yes	1	0	8
8	L:L:?1	R:R:F251	14.27	Yes	Yes	1	0	6
9	L:L:?1	R:R:F252	7.13	Yes	Yes	1	0	7
10	L:L:?1	R:R:Y255	3.92	Yes	No	0	0	6
11	L:L:?1	R:R:F276	8.15	Yes	Yes	1	0	5
12	R:R:L6	R:R:L8	4.15	No	No	0	3	4
13	R:R:K7	R:R:L10	4.23	No	No	0	4	5
14	R:R:K11	R:R:K7	4.31	Yes	No	0	5	4
15	R:R:L13	R:R:V9	4.47	No	No	0	5	5
16	R:R:K11	R:R:L15	8.46	Yes	No	0	5	6
17	R:R:I70	R:R:T12	4.56	No	No	0	5	6
18	R:R:A66	R:R:L15	4.73	No	No	0	6	6
19	R:R:L15	R:R:W277	12.53	No	Yes	0	6	4
20	R:R:I18	R:R:S284	3.1	No	Yes	0	7	7
21	R:R:I19	R:R:M62	5.83	No	Yes	0	5	7
22	R:R:S21	R:R:S284	4.89	No	Yes	0	5	7
23	R:R:A22	R:R:S284	3.42	No	Yes	0	7	7
24	R:R:F24	R:R:L28	3.65	No	Yes	0	3	6
25	R:R:G25	R:R:L28	3.42	No	Yes	0	8	6
26	R:R:A51	R:R:N26	4.69	No	Yes	0	9	9
27	R:R:D54	R:R:N26	16.16	No	Yes	0	9	9
28	R:R:N26	R:R:T55	5.85	Yes	No	0	9	8
29	R:R:N26	R:R:P287	14.66	Yes	No	0	9	9
30	R:R:L27	R:R:T55	4.42	No	No	0	3	8
31	R:R:L28	R:R:V29	4.47	Yes	No	0	6	9
32	R:R:F301	R:R:L28	4.87	No	Yes	0	7	6
33	R:R:A51	R:R:V29	3.39	No	No	0	9	9
34	R:R:I34	R:R:V30	3.07	No	No	0	3	7
35	R:R:S32	R:R:T304	6.4	No	No	0	8	4
36	R:R:V33	R:R:V48	8.02	No	No	0	7	5
37	R:R:H36	R:R:R35	3.39	Yes	No	0	5	6
38	R:R:A307	R:R:R35	4.15	No	No	0	5	6
39	R:R:H36	R:R:K38	22.27	Yes	No	0	5	5
40	R:R:E303	R:R:H36	4.92	No	Yes	0	4	5
41	R:R:L39	R:R:N44	4.12	No	No	0	8	8
42	R:R:E296	R:R:L39	5.3	No	No	0	6	8
43	R:R:I41	R:R:N44	4.25	No	No	0	7	8
44	R:R:T42	R:R:V125	3.17	No	Yes	0	6	7
45	R:R:D105	R:R:T43	5.78	No	No	5	9	8
46	R:R:T43	R:R:Y116	4.99	No	Yes	5	8	7
47	R:R:F297	R:R:N44	6.04	Yes	No	0	8	8
48	R:R:F46	R:R:I102	3.77	Yes	No	0	7	8
49	R:R:D105	R:R:F46	4.78	No	Yes	0	9	7
50	R:R:F46	R:R:V125	9.18	Yes	Yes	0	7	7
51	R:R:F46	R:R:M128	3.73	Yes	No	0	7	5
52	R:R:F297	R:R:I47	8.79	Yes	No	0	8	8
53	R:R:H98	R:R:S49	5.58	Yes	No	4	8	9
54	R:R:L129	R:R:S49	7.51	No	No	4	7	9
55	R:R:S49	R:R:W133	3.71	No	Yes	4	9	9
56	R:R:H98	R:R:L50	10.29	Yes	No	0	8	9
57	R:R:D54	R:R:S283	8.83	No	No	0	9	9
58	R:R:F91	R:R:L56	15.83	No	No	0	6	6
59	R:R:M62	R:R:V57	3.04	Yes	No	0	7	7
60	R:R:S283	R:R:V57	6.46	No	No	0	9	7
61	R:R:F60	R:R:F83	6.43	No	No	0	5	4
62	R:R:C87	R:R:F60	5.59	No	No	0	4	5
63	R:R:A61	R:R:D88	3.09	No	No	0	6	6
64	R:R:M62	R:R:W277	4.65	Yes	Yes	1	7	4
65	R:R:M62	R:R:Y280	8.38	Yes	Yes	1	7	7
66	R:R:F64	R:R:F76	5.36	No	No	0	4	6
67	R:R:F64	R:R:F83	3.22	No	No	0	4	4
68	R:R:F64	R:R:W84	11.02	No	Yes	0	4	6
69	R:R:N65	R:R:W84	4.52	Yes	Yes	0	6	6
70	R:R:F276	R:R:N65	3.62	Yes	Yes	1	5	6
71	R:R:N65	R:R:W277	14.69	Yes	Yes	1	6	4
72	R:R:N65	R:R:Y280	5.81	Yes	Yes	1	6	7
73	R:R:V68	R:R:W74	4.9	No	Yes	0	3	8
74	R:R:I70	R:R:S71	4.64	No	No	0	5	4
75	R:R:F76	R:R:W74	8.02	No	Yes	2	6	8
76	R:R:V80	R:R:W74	3.68	No	Yes	2	4	8
77	R:R:C81	R:R:W74	3.92	No	Yes	2	9	8
78	R:R:W74	R:R:W84	5.62	Yes	Yes	0	8	6
79	R:R:C165	R:R:W74	6.53	No	Yes	2	9	8
80	R:R:F76	R:R:V80	18.35	No	No	2	6	4
81	R:R:C81	R:R:N85	4.72	No	No	0	9	4
82	R:R:C165	R:R:C81	7.28	No	No	2	9	9
83	R:R:D82	R:R:I144	4.2	No	No	3	5	5
84	R:R:D82	R:R:Y149	8.05	No	Yes	3	5	5
85	R:R:N85	R:R:W84	5.65	No	Yes	0	4	6
86	R:R:D88	R:R:W84	12.28	No	Yes	0	6	6
87	R:R:F167	R:R:N85	9.67	No	No	0	4	4
88	R:R:F141	R:R:S86	5.28	No	No	0	5	5
89	R:R:I144	R:R:S86	9.29	No	No	0	5	5
90	R:R:D88	R:R:Y280	8.05	No	Yes	0	6	7
91	R:R:S140	R:R:V89	3.23	No	No	0	7	4
92	R:R:V89	R:R:Y173	3.79	No	Yes	0	4	7
93	R:R:F91	R:R:L90	6.09	No	No	0	6	4
94	R:R:L90	R:R:S140	7.51	No	No	0	4	7
95	R:R:F91	R:R:W133	4.01	No	Yes	0	6	9
96	R:R:S92	R:R:W248	4.94	No	Yes	1	6	8
97	R:R:S136	R:R:T93	7.99	No	No	0	8	6
98	R:R:S181	R:R:T93	7.99	No	No	1	6	6
99	R:R:A94	R:R:W133	3.89	No	Yes	0	7	9
100	R:R:A94	R:R:S136	3.42	No	No	0	7	8
101	R:R:I96	R:R:P185	3.39	No	No	0	8	8
102	R:R:I96	R:R:W248	11.74	No	Yes	0	8	8
103	R:R:A132	R:R:M97	4.83	No	No	0	7	6
104	R:R:H98	R:R:L129	3.86	Yes	No	4	8	7
105	R:R:H98	R:R:W133	7.41	Yes	Yes	4	8	9
106	R:R:F244	R:R:L99	3.65	Yes	No	0	9	8
107	R:R:L99	R:R:Y290	3.52	No	Yes	0	8	9
108	R:R:C100	R:R:I188	6.55	No	No	0	7	6
109	R:R:C101	R:R:M128	4.86	No	No	0	6	5
110	R:R:I102	R:R:Y290	4.84	No	Yes	0	8	9
111	R:R:S103	R:R:T192	6.4	No	No	0	9	7
112	R:R:S103	R:R:Y193	6.36	No	Yes	0	9	9
113	R:R:D105	R:R:Y116	4.6	No	Yes	5	9	7
114	R:R:R106	R:R:Y193	8.23	No	Yes	1	9	9
115	R:R:R106	R:R:Y290	9.26	No	Yes	1	9	9
116	R:R:I111	R:R:Y107	12.09	No	No	6	7	8
117	R:R:T192	R:R:Y107	7.49	No	No	0	7	8
118	R:R:R195	R:R:Y107	6.17	Yes	No	6	5	8
119	R:R:K119	R:R:Y108	7.17	No	No	0	5	4
120	R:R:I120	R:R:Y108	3.63	No	No	0	6	4
121	R:R:A109	R:R:Y116	6.67	No	Yes	0	8	7
122	R:R:I110	R:R:I196	8.83	No	No	0	8	8
123	R:R:I111	R:R:R195	5.01	No	Yes	6	7	5
124	R:R:E115	R:R:K112	4.05	No	No	0	4	5
125	R:R:E115	R:R:K119	13.5	No	No	0	4	5
126	R:R:P117	R:R:Y116	4.17	No	Yes	0	3	7
127	R:R:I120	R:R:Y116	7.25	No	Yes	0	6	7
128	R:R:G122	R:R:T121	3.64	No	No	0	2	7
129	R:R:I127	R:R:R123	6.26	No	No	0	2	4
130	R:R:L138	R:R:V134	4.47	No	No	0	4	4
131	R:R:I139	R:R:Y173	3.63	No	Yes	0	5	7
132	R:R:I139	R:R:V180	6.14	No	No	0	5	4
133	R:R:F141	R:R:F145	3.22	No	No	0	5	3
134	R:R:I142	R:R:P143	6.77	No	No	0	6	5
135	R:R:I144	R:R:Y149	15.71	No	Yes	3	5	5
136	R:R:L146	R:R:W148	7.97	No	No	0	4	5
137	R:R:T150	R:R:Y149	17.48	No	Yes	0	3	5
138	R:R:K158	R:R:Y149	3.58	No	Yes	0	4	5
139	R:R:H154	R:R:T150	8.21	Yes	No	0	2	3
140	R:R:E153	R:R:T151	11.29	No	No	0	1	3
141	R:R:H154	R:R:Y157	7.62	Yes	No	0	2	3
142	R:R:H154	R:R:K158	13.1	Yes	No	0	2	4
143	R:R:H154	R:R:V168	11.07	Yes	No	0	2	3
144	R:R:L155	R:R:V159	4.47	No	No	0	3	3
145	R:R:E160	R:R:Y157	13.47	No	No	7	4	3
146	R:R:H161	R:R:Y157	6.53	No	No	7	5	3
147	R:R:E160	R:R:H161	6.15	No	No	7	4	5
148	R:R:D163	R:R:P162	3.22	No	No	0	3	3
149	R:R:F167	R:R:V169	3.93	No	No	0	4	3
150	R:R:V169	R:R:Y173	12.62	No	Yes	0	3	7
151	R:R:V169	R:R:Y255	6.31	No	No	0	3	6
152	R:R:N170	R:R:P172	8.15	No	No	0	5	2
153	R:R:N170	R:R:Y173	3.49	No	Yes	0	5	7
154	R:R:K171	R:R:P172	3.35	No	No	0	3	2
155	R:R:I176	R:R:Y173	3.63	No	Yes	0	4	7
156	R:R:A174	R:R:T259	5.03	No	No	0	5	3
157	R:R:S177	R:R:S181	3.26	No	No	1	5	6
158	R:R:S178	R:R:W183	6.18	No	No	0	5	4
159	R:R:S178	R:R:V256	3.23	No	No	0	5	6
160	R:R:C186	R:R:F182	5.59	No	Yes	0	6	8
161	R:R:F182	R:R:F244	6.43	Yes	Yes	1	8	9
162	R:R:F182	R:R:W248	4.01	Yes	Yes	1	8	8
163	R:R:F182	R:R:L249	4.87	Yes	No	0	8	6
164	R:R:F182	R:R:F252	19.29	Yes	Yes	1	8	7
165	R:R:I184	R:R:P185	5.08	No	No	0	5	8
166	R:R:C186	R:R:L190	3.17	No	No	0	6	5
167	R:R:I188	R:R:T192	3.04	No	No	0	6	7
168	R:R:M189	R:R:M241	5.78	No	Yes	1	8	8
169	R:R:F244	R:R:M189	6.22	Yes	No	1	9	8
170	R:R:F191	R:R:R195	4.28	No	Yes	0	3	5
171	R:R:I196	R:R:Y193	4.84	No	Yes	0	8	9
172	R:R:L237	R:R:Y193	4.69	No	Yes	0	8	9
173	R:R:I240	R:R:Y193	3.63	No	Yes	0	8	9
174	R:R:M241	R:R:Y193	3.59	Yes	Yes	1	8	9
175	R:R:Y193	R:R:Y290	4.96	Yes	Yes	1	9	9
176	R:R:T201	R:R:Y197	7.49	No	Yes	0	5	5
177	R:R:A234	R:R:Y197	4	No	Yes	0	6	5
178	R:R:L237	R:R:Y197	5.86	No	Yes	0	8	5
179	R:R:K205	R:R:R202	13.61	No	No	0	4	4
180	R:R:F293	R:R:T236	9.08	No	No	0	7	8
181	R:R:F293	R:R:I240	5.02	No	No	0	7	8
182	R:R:F244	R:R:M241	4.98	Yes	Yes	1	9	8
183	R:R:I245	R:R:M241	4.37	No	Yes	0	5	8
184	R:R:F244	R:R:W248	8.02	Yes	Yes	1	9	8
185	R:R:C247	R:R:N282	9.45	No	No	0	9	9
186	R:R:F252	R:R:W248	8.02	Yes	Yes	1	7	8
187	R:R:N282	R:R:W248	7.91	No	Yes	0	9	8
188	R:R:F251	R:R:F252	8.57	Yes	Yes	1	6	7
189	R:R:F251	R:R:L275	4.87	Yes	No	0	6	5
190	R:R:F251	R:R:F276	12.86	Yes	Yes	1	6	5
191	R:R:I258	R:R:W254	14.09	No	No	0	3	4
192	R:R:L275	R:R:W254	5.69	No	No	0	5	4
193	R:R:L275	R:R:V271	4.47	No	No	0	5	4
194	R:R:D273	R:R:L274	6.79	No	No	0	3	4
195	R:R:D273	R:R:W277	4.47	No	Yes	0	3	4
196	R:R:F276	R:R:Y280	6.19	Yes	Yes	1	5	7
197	R:R:W277	R:R:Y280	11.58	Yes	Yes	1	4	7
198	R:R:I278	R:R:L281	4.28	No	No	0	7	5
199	R:R:N282	R:R:N286	13.62	No	No	0	9	9
200	R:R:A291	R:R:F297	4.16	No	Yes	0	7	8
201	R:R:A291	R:R:F301	4.16	No	No	0	7	7
202	R:R:F293	R:R:Y292	5.16	No	No	0	7	5
203	R:R:F297	R:R:N294	3.62	Yes	No	0	8	8
204	R:R:K302	R:R:L305	7.05	No	No	0	5	6
205	R:R:L305	R:R:Q306	5.32	No	No	0	6	4
206	R:R:F182	R:R:W183	3.01	Yes	No	0	8	4
207	R:R:L75	R:R:S71	3	No	No	0	2	4
208	R:R:L253	R:R:S257	3	No	No	0	5	4
209	R:R:Y149	R:R:Y173	2.98	Yes	Yes	3	5	7
210	R:R:N77	R:R:V80	2.96	No	No	0	8	4
211	R:R:I240	R:R:I289	2.94	No	No	0	8	8
212	R:R:A300	R:R:H36	2.93	No	Yes	0	6	5
213	R:R:A53	R:R:H98	2.93	No	Yes	0	8	8
214	R:R:I18	R:R:L281	2.85	No	No	0	7	5
215	R:R:K38	R:R:L39	2.82	No	No	0	5	8
216	R:R:G279	R:R:W248	2.81	No	Yes	0	7	8
217	R:R:H36	R:R:S32	2.79	Yes	No	0	5	8
218	R:R:L270	R:R:L274	2.77	No	No	0	1	4
219	R:R:E199	R:R:I111	2.73	No	No	0	5	7
220	R:R:A174	R:R:Y255	2.67	No	No	0	5	6
221	R:R:H154	R:R:I166	2.65	Yes	No	0	2	4
222	R:R:F276	R:R:V272	2.62	Yes	No	0	5	4
223	R:R:V125	R:R:Y45	2.52	Yes	No	0	7	4
224	R:R:D163	R:R:R73	2.38	No	No	0	3	4
225	R:R:G72	R:R:S71	1.86	No	No	0	3	4
226	R:R:G137	R:R:S136	1.86	No	No	0	3	8
227	R:R:G137	R:R:S140	1.86	No	No	0	3	7
228	R:R:G122	R:R:V125	1.84	No	Yes	0	2	7
229	R:R:A132	R:R:C101	1.81	No	No	0	7	6
230	R:R:A22	R:R:A58	1.79	No	No	0	7	7
231	R:R:A200	R:R:A233	1.79	No	No	0	8	8
232	R:R:G242	R:R:I245	1.76	No	No	0	5	5
233	R:R:G147	R:R:L146	1.71	No	No	0	3	4
234	R:R:G238	R:R:L237	1.71	No	No	0	5	8
235	R:R:A58	R:R:V23	1.7	No	No	0	7	6
236	R:R:A51	R:R:V30	1.7	No	No	0	9	7
237	R:R:K112	R:R:P113	1.67	No	No	0	5	8
238	R:R:C131	R:R:I127	1.64	No	No	0	3	2
239	R:R:C247	R:R:I278	1.64	No	No	0	9	7
240	R:R:L249	R:R:P250	1.64	No	No	0	6	9
241	R:R:S20	R:R:V16	1.62	No	No	0	4	5
242	R:R:S135	R:R:V180	1.62	No	No	0	3	4
243	R:R:S179	R:R:V180	1.62	No	No	0	4	4
244	R:R:A243	R:R:I289	1.62	No	No	0	6	8
245	R:R:A14	R:R:K11	1.61	No	Yes	0	5	5
246	R:R:T12	R:R:V16	1.59	No	No	0	6	5
247	R:R:T130	R:R:V134	1.59	No	No	0	5	4
248	R:R:P162	R:R:Q78	1.58	No	No	0	3	3
249	R:R:I175	R:R:S178	1.55	No	No	0	5	5
250	R:R:I34	R:R:V33	1.54	No	No	0	3	7
251	R:R:I188	R:R:V104	1.54	No	No	0	6	6
252	R:R:H161	R:R:P162	1.53	No	No	0	5	3
253	R:R:I19	R:R:T63	1.52	No	No	0	5	7
254	R:R:M128	R:R:T124	1.51	No	No	0	5	5
255	R:R:K11	R:R:T69	1.5	Yes	No	0	5	4
256	R:R:K205	R:R:T201	1.5	No	No	0	4	5
257	R:R:L285	R:R:S284	1.5	No	Yes	0	6	7
258	R:R:L8	R:R:V9	1.49	No	No	0	4	5
259	R:R:N286	R:R:S95	1.49	No	No	0	9	9
260	R:R:L155	R:R:V156	1.49	No	No	0	3	4
261	R:R:I239	R:R:I289	1.47	No	No	0	7	8
262	R:R:N152	R:R:T151	1.46	No	No	0	2	3
263	R:R:N170	R:R:T151	1.46	No	No	0	5	3
264	R:R:G147	R:R:Y149	1.45	No	Yes	0	3	5
265	R:R:I239	R:R:K235	1.45	No	No	0	7	6
266	R:R:K7	R:R:L8	1.41	No	No	0	4	4
267	R:R:E115	R:R:T118	1.41	No	No	0	4	4
268	R:R:K158	R:R:L155	1.41	No	No	0	4	3
269	R:R:P143	R:R:Y149	1.39	No	Yes	3	5	5
270	R:R:P143	R:R:Y173	1.39	No	Yes	3	5	7
271	R:R:E303	R:R:K302	1.35	No	No	0	4	5
272	R:R:A233	R:R:Y197	1.33	No	Yes	0	8	5
273	R:R:F145	R:R:T79	1.3	No	No	0	3	2
274	R:R:F60	R:R:L59	1.22	No	No	0	5	5
275	R:R:L75	R:R:R73	1.21	No	No	0	2	4
276	R:R:Q203	R:R:R202	1.17	No	No	0	6	4
277	R:R:H37	R:R:R40	1.13	No	No	0	5	7
278	R:R:R298	R:R:Y292	1.03	No	No	0	8	5
279	R:R:R195	R:R:W194	1	Yes	No	0	5	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.07818	11	1	0
2	R:R:K11	3.97	4	0	5
3	R:R:N26	10.34	4	0	9
4	R:R:L28	4.1025	4	0	6
5	R:R:H36	7.26	5	0	5
6	R:R:F46	5.365	4	0	7
7	R:R:M62	5.475	4	1	7
8	R:R:N65	7.16	4	1	6
9	R:R:W74	5.445	6	2	8
10	R:R:W84	7.818	5	0	6
11	R:R:H98	6.014	5	4	8
12	R:R:Y116	5.536	5	5	7
13	R:R:V125	4.1775	4	0	7
14	R:R:W133	4.755	4	4	9
15	R:R:Y149	7.23429	7	3	5
16	R:R:H154	8.53	5	0	2
17	R:R:Y173	4.50429	7	3	7
18	R:R:F182	7.2	6	1	8
19	R:R:Y193	5.18571	7	1	9
20	R:R:R195	4.115	4	6	5
21	R:R:Y197	4.67	4	0	5
22	R:R:M241	4.68	4	1	8
23	R:R:F244	5.86	5	1	9
24	R:R:W248	6.4075	8	1	8
25	R:R:F251	10.1425	4	1	6
26	R:R:F252	10.7525	4	1	7
27	R:R:F276	6.688	5	1	5
28	R:R:W277	9.584	5	1	4
29	R:R:Y280	8.002	5	1	7
30	R:R:S284	3.2275	4	0	7
31	R:R:Y290	5.645	4	1	9
32	R:R:F297	5.6525	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F276	86.1667	8.15	Yes	Yes	1	0	5
2	R:R:F276	R:R:N65	27.3887	3.62	Yes	Yes	1	5	6
3	R:R:N65	R:R:W277	22.1017	14.69	Yes	Yes	1	6	4
4	R:R:L15	R:R:W277	28.6205	12.53	No	Yes	0	6	4
5	R:R:K11	R:R:L15	23.7314	8.46	Yes	No	0	5	6
6	R:R:K11	R:R:K7	16.019	4.31	Yes	No	0	5	4
7	R:R:K7	R:R:L8	10.7211	1.41	No	No	0	4	4
8	R:R:F276	R:R:Y280	64.5773	6.19	Yes	Yes	1	5	7
9	R:R:W277	R:R:Y280	17.1472	11.58	Yes	Yes	1	4	7
10	L:L:?1	R:R:V89	71.4722	13.71	Yes	No	0	0	4
11	R:R:V89	R:R:Y173	69.2756	3.79	No	Yes	0	4	7
12	R:R:Y149	R:R:Y173	63.8415	2.98	Yes	Yes	3	5	7
13	R:R:T150	R:R:Y149	24.489	17.48	No	Yes	0	3	5
14	R:R:H154	R:R:T150	23.1645	8.21	Yes	No	0	2	3
15	R:R:H154	R:R:Y157	39.2162	7.62	Yes	No	0	2	3
16	R:R:H161	R:R:Y157	33.6131	6.53	No	No	7	5	3
17	R:R:H161	R:R:P162	30.8933	1.53	No	No	0	5	3
18	R:R:D163	R:R:P162	25.2902	3.22	No	No	0	3	3
19	R:R:D163	R:R:R73	22.4723	2.38	No	No	0	3	4
20	R:R:L75	R:R:R73	19.6435	1.21	No	No	0	2	4
21	R:R:L75	R:R:S71	16.8038	3	No	No	0	2	4
22	R:R:I70	R:R:S71	11.0917	4.64	No	No	0	5	4
23	R:R:K158	R:R:Y149	28.7676	3.58	No	Yes	0	4	5
24	R:R:H154	R:R:K158	23.6115	13.1	Yes	No	0	2	4
25	L:L:?1	R:R:W248	100	3.81	Yes	Yes	1	0	8
26	R:R:N282	R:R:W248	20.4012	7.91	No	Yes	0	9	8
27	R:R:C247	R:R:N282	15.8555	9.45	No	No	0	9	9
28	R:R:C247	R:R:I278	14.3184	1.64	No	No	0	9	7
29	R:R:I278	R:R:L281	12.7705	4.28	No	No	0	7	5
30	R:R:I18	R:R:L281	11.2116	2.85	No	No	0	7	5
31	R:R:M62	R:R:Y280	51.8559	8.38	Yes	Yes	1	7	7
32	R:R:M62	R:R:V57	54.652	3.04	Yes	No	0	7	7
33	R:R:S283	R:R:V57	53.3112	6.46	No	No	0	9	7
34	R:R:D54	R:R:S283	51.9594	8.83	No	No	0	9	9
35	R:R:D54	R:R:N26	50.5968	16.16	No	Yes	0	9	9
36	R:R:A51	R:R:N26	45.0373	4.69	No	Yes	0	9	9
37	R:R:A51	R:R:V29	37.8427	3.39	No	No	0	9	9
38	R:R:L28	R:R:V29	36.3711	4.47	Yes	No	0	6	9
39	R:R:F301	R:R:L28	31.8744	4.87	No	Yes	0	7	6
40	R:R:A291	R:R:F301	30.5336	4.16	No	No	0	7	7
41	R:R:A291	R:R:F297	29.171	4.16	No	Yes	0	7	8
42	R:R:F297	R:R:N44	24.5272	6.04	Yes	No	0	8	8
43	R:R:L39	R:R:N44	21.5349	4.12	No	No	0	8	8
44	R:R:K38	R:R:L39	18.3409	2.82	No	No	0	5	8
45	R:R:H36	R:R:K38	16.7275	22.27	Yes	No	0	5	5
46	R:R:F244	R:R:W248	79.6588	8.02	Yes	Yes	1	9	8
47	R:R:F244	R:R:L99	35.1883	3.65	Yes	No	0	9	8
48	R:R:L99	R:R:Y290	34.1418	3.52	No	Yes	0	8	9
49	R:R:I102	R:R:Y290	36.5836	4.84	No	Yes	0	8	9
50	R:R:F46	R:R:I102	35.1774	3.77	Yes	No	0	7	8
51	R:R:D105	R:R:F46	19.262	4.78	No	Yes	0	9	7
52	R:R:D105	R:R:Y116	16.128	4.6	No	Yes	5	9	7
53	L:L:?1	R:R:T93	14.471	3.7	Yes	No	1	0	6
54	R:R:S136	R:R:T93	13.0866	7.99	No	No	0	8	6
55	R:R:A94	R:R:S136	10.7156	3.42	No	No	0	7	8
56	R:R:S140	R:R:V89	10.9609	3.23	No	No	0	7	4
57	L:L:?1	R:R:F167	15.7028	3.06	Yes	No	0	0	4
58	R:R:F167	R:R:N85	21.851	9.67	No	No	0	4	4
59	R:R:N85	R:R:W84	15.1033	5.65	No	Yes	0	4	6
60	R:R:F64	R:R:W84	15.7628	11.02	No	Yes	0	4	6
61	R:R:F64	R:R:F83	10.6884	3.22	No	No	0	4	4
62	R:R:N65	R:R:W84	17.6705	4.52	Yes	Yes	0	6	6
63	R:R:W74	R:R:W84	14.422	5.62	Yes	Yes	0	8	6
64	R:R:F244	R:R:M241	47.9097	4.98	Yes	Yes	1	9	8
65	R:R:M241	R:R:Y193	45.179	3.59	Yes	Yes	1	8	9
66	R:R:S103	R:R:Y193	17.4906	6.36	No	Yes	0	9	9
67	R:R:S103	R:R:T192	15.9372	6.4	No	No	0	9	7
68	R:R:I120	R:R:Y116	11.4406	7.25	No	Yes	0	6	7
69	R:R:F182	R:R:W248	10.5412	4.01	Yes	Yes	1	8	8
70	R:R:F182	R:R:W183	12.5307	3.01	Yes	No	0	8	4
71	L:L:?1	R:R:F252	10.6829	7.13	Yes	Yes	1	0	7
72	R:R:F182	R:R:F252	16.3296	19.29	Yes	Yes	1	8	7
73	R:R:L237	R:R:Y193	16.128	4.69	No	Yes	0	8	9
74	R:R:I240	R:R:Y193	14.1604	3.63	No	Yes	0	8	9
75	R:R:L237	R:R:Y197	12.9776	5.86	No	Yes	0	8	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:V89	13.71	1	Yes	No	0	4	0	1
L:L:?1	R:R:S92	7.54	1	Yes	No	0	6	0	1
L:L:?1	R:R:T93	3.7	1	Yes	No	0	6	0	1
L:L:?1	R:R:F167	3.06	1	Yes	No	0	4	0	1
L:L:?1	R:R:S177	5.03	1	Yes	No	0	5	0	1
L:L:?1	R:R:S181	7.54	1	Yes	No	0	6	0	1
L:L:?1	R:R:W248	3.81	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F251	14.27	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F252	7.13	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:Y255	3.92	1	Yes	No	0	6	0	1
L:L:?1	R:R:F276	8.15	1	Yes	Yes	0	5	0	1
R:R:F276	R:R:N65	3.62	1	Yes	Yes	5	6	1	2
R:R:N65	R:R:Y280	5.81	1	Yes	Yes	6	7	2	2
R:R:F167	R:R:N85	9.67	0	No	No	4	4	1	2
R:R:S140	R:R:V89	3.23	0	No	No	7	4	2	1
R:R:V89	R:R:Y173	3.79	0	No	Yes	4	7	1	2
R:R:S92	R:R:W248	4.94	1	No	Yes	6	8	1	1
R:R:S136	R:R:T93	7.99	0	No	No	8	6	2	1
R:R:S181	R:R:T93	7.99	1	No	No	6	6	1	1
R:R:I96	R:R:W248	11.74	0	No	Yes	8	8	2	1
R:R:F167	R:R:V169	3.93	0	No	No	4	3	1	2
R:R:V169	R:R:Y173	12.62	0	No	Yes	3	7	2	2
R:R:V169	R:R:Y255	6.31	0	No	No	3	6	2	1
R:R:S177	R:R:S181	3.26	1	No	No	5	6	1	1
R:R:F182	R:R:F244	6.43	1	Yes	Yes	8	9	2	2
R:R:F182	R:R:W248	4.01	1	Yes	Yes	8	8	2	1
R:R:F182	R:R:F252	19.29	1	Yes	Yes	8	7	2	1
R:R:F244	R:R:W248	8.02	1	Yes	Yes	9	8	2	1
R:R:F252	R:R:W248	8.02	1	Yes	Yes	7	8	1	1
R:R:N282	R:R:W248	7.91	0	No	Yes	9	8	2	1
R:R:F251	R:R:F252	8.57	1	Yes	Yes	6	7	1	1
R:R:F251	R:R:L275	4.87	1	Yes	No	6	5	1	2
R:R:F251	R:R:F276	12.86	1	Yes	Yes	6	5	1	1
R:R:F276	R:R:Y280	6.19	1	Yes	Yes	5	7	1	2
R:R:G279	R:R:W248	2.81	0	No	Yes	7	8	2	1
R:R:A174	R:R:Y255	2.67	0	No	No	5	6	2	1
R:R:F276	R:R:V272	2.62	1	Yes	No	5	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9M57_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.04
Number of Linked Nodes	252
Number of Links	279
Number of Hubs	32
Number of Links mediated by Hubs	135
Number of Communities	7
Number of Nodes involved in Communities	43
Number of Links involved in Communities	58

Path Summary
Number Of Nodes in MetaPath	76
Number Of Links MetaPath	75
Number of Shortest Paths	43484
Length Of Smallest Path	3
Average Path Length	13.0216
Length of Longest Path	38
Minimum Path Strength	1.42
Average Path Strength	6.17249
Maximum Path Strength	16.595
Minimum Path Correlation	0.7
Average Path Correlation	0.921834
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.125
Average % Of Corr. Nodes	47.8562
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.7286
Maximum Path Hubs %	100

Details about the values in these tables can be found in the corresponding documentation page .


Code	OTR
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	OTR
Name	4-(2R-AMINO-1-HYDROXYETHYL)PHENOL
Synonyms	R-OCTOPAMINE
Identifier
Formula	C8 H11 N O2
Molecular Weight	153.178
SMILES
PubChem	440266
Formal Charge	0
Total Atoms	22
Total Chiral Atoms	1
Total Bonds	22
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	B7Q337
Sequence	>9M57_nogp_Chain_R L K L V L K T L A L V T I I S S A V F G N L L V V T S V I R H H K L R I T T N Y F I V S L A L A D T L V A L F A M T F N A S V T I S G R W L F N Q T V C D F W N S C D V L F S T A S I M H L C C I S V D R Y Y A I I K P L E Y P T K I T G R T V A I M L T C A W V S S G L I S F I P I F L G W Y T T N E H L V Y K V E H P D E C I F V V N K P Y A I I S S S V S F W I P C C I M L F T Y W R I Y V E A T R Q E K M L C K A A K T L G I I M G A F I L C W L P F F L W Y V S I T M L V V D L L F W I G Y L N S S L N P V I Y A Y F N R E F R Q A F K E T L Q A I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9M55	A	Amine	Adrenergic	Oct-Beta2	Ixodes scapularis	DPMF	-	chim(NtGi1-Gs)/β1/γ2	3.39	2025-12-17	10.1093/pnasnexus/pgaf376
	9M55 (No Gprot)	A	Amine	Adrenergic	Oct-Beta2	Ixodes scapularis	DPMF	-		3.39	2025-12-17	10.1093/pnasnexus/pgaf376
	9M57	A	Amine	Adrenergic	Oct-Beta2	Ixodes scapularis	Octopamine	-	chim(NtGi1-Gs)/β1/γ2	3.65	2025-12-17	10.1093/pnasnexus/pgaf376
	9M57 (No Gprot)	A	Amine	Adrenergic	Oct-Beta2	Ixodes scapularis	Octopamine	-		3.65	2025-12-17	10.1093/pnasnexus/pgaf376

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9M57_nogp.zip

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