Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:H41 5.495466
2A:A:V214 3.25566
3A:A:F219 6.1725468
4A:A:M221 3.2225408
5A:A:R232 14.838528
6A:A:I235 3.535449
7A:A:T242 3.37468
8A:A:I244 5.218548
9A:A:F246 7.6975409
10A:A:F273 4.9156129
11A:A:N279 4.2475448
12A:A:L282 4.846549
13A:A:L296 3.5825406
14A:A:F345 5.6245128
15A:A:Y360 6.1345158
16A:A:F376 6.488568
17A:A:D378 7.98754157
18A:A:I383 3.9275468
19A:A:R385 4.0025405
20A:A:L388 4.67418
21A:A:L393 3.768518
22B:B:L30 3.486505
23B:B:V40 2.285403
24B:B:L51 8.274539
25B:B:H54 7.352509
26B:B:K57 8.51549
27B:B:Y59 7.58448
28B:B:W63 6.78637
29B:B:L70 4.728535
30B:B:S72 4.44439
31B:B:Q75 7.642549
32B:B:I81 3.58587
33B:B:W82 9.65639
34B:B:K89 5.946539
35B:B:H91 5.175405
36B:B:I93 5.37333687
37B:B:L95 5.568588
38B:B:W99 10.025609
39B:B:Y105 4.63833686
40B:B:Y111 5.3965114
41B:B:C114 3.496588
42B:B:I123 4.71254116
43B:B:Y124 5.8525486
44B:B:S136 3.12254114
45B:B:H142 8.25333629
46B:B:F151 4.6725119
47B:B:L152 4.1825453
48B:B:V158 3.9625455
49B:B:T159 5.66429
50B:B:G162 3.595429
51B:B:D163 8.22429
52B:B:L168 4.3556
53B:B:W169 11.755428
54B:B:F180 9.918557
55B:B:H183 7.03833659
56B:B:D186 10.2475429
57B:B:M188 5.8875428
58B:B:L190 5.075455
59B:B:L198 5.0925423
60B:B:F199 6.27833659
61B:B:V200 6.2025426
62B:B:S201 5.1725459
63B:B:D205 4.986559
64B:B:K209 10.0275406
65B:B:L210 6.476525
66B:B:W211 9.72658
67B:B:R219 10.425425
68B:B:Q220 10.402527
69B:B:F222 6.988528
70B:B:H225 9.365629
71B:B:S227 5.9675426
72B:B:D228 8.28429
73B:B:I232 5.8475428
74B:B:F234 4.47525
75B:B:F235 6.02857776
76B:B:P236 5.32477
77B:B:F241 6.40167626
78B:B:T243 6.28528
79B:B:S245 5.8775429
80B:B:D246 7.0375429
81B:B:D247 5.3775429
82B:B:T249 5.816526
83B:B:R251 9.87333628
84B:B:F253 6.585626
85B:B:Y264 5.78833675
86B:B:H266 4.6625404
87B:B:I269 4.15184
88B:B:F278 7.2325477
89B:B:R283 6.64509
90B:B:L285 5.1075476
91B:B:L286 4.33754207
92B:B:Y289 7.1965187
93B:B:H311 8.87599
94B:B:D323 5.335437
95B:B:M325 5.295435
96B:B:V327 3.6406
97B:B:W332 10.304549
98B:B:D333 7.806599
99B:B:L336 4.475437
100B:B:K337 8.5875496
101B:B:W339 10.415699
102B:B:N340 6.995439
103G:G:R27 11.26254178
104G:G:V30 3.27754178
105G:G:Y40 6.835476
106G:G:D48 6.4454199
107G:G:L51 2.865406
108G:G:N59 6.078539
109G:G:P60 7.85439
110G:G:F61 5.23714738
111L:L:?1 6.733331210
112R:R:K11 3.97405
113R:R:L15 7.1425406
114R:R:N26 10.34409
115R:R:L28 4.10254216
116R:R:V29 3.2754219
117R:R:H36 7.26505
118R:R:N44 4.3325408
119R:R:F46 4.855107
120R:R:M62 5.475417
121R:R:F64 5.046514
122R:R:N65 7.16416
123R:R:W74 5.09714718
124R:R:V80 6.9025414
125R:R:W84 7.818516
126R:R:V89 5.8375414
127R:R:F91 6.268506
128R:R:H98 6.0145138
129R:R:L99 3.1725408
130R:R:D105 4.494109
131R:R:I111 5.6854227
132R:R:L114 5.7525466
133R:R:Y116 5.5365107
134R:R:V125 4.1775407
135R:R:W133 4.7554139
136R:R:S136 4.0675408
137R:R:Y149 7.23429715
138R:R:H154 8.53502
139R:R:F167 4.82414
140R:R:Y173 4.50429717
141R:R:S181 5.3575416
142R:R:F182 7.2618
143R:R:Y193 5.18571719
144R:R:R195 4.1154225
145R:R:I196 4.8425418
146R:R:L237 4.1025408
147R:R:M241 4.68418
148R:R:F244 5.86519
149R:R:W248 6.4075818
150R:R:F251 10.1425416
151R:R:F252 9.13517
152R:R:F276 6.688515
153R:R:W277 9.584514
154R:R:Y280 7.15833617
155R:R:S284 3.2275407
156R:R:Y290 5.645419
157R:R:F297 5.046508
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:D66 B:B:R68 20.23223.57NoNo085
2B:B:D66 B:B:L69 20.09125.43NoNo085
3B:B:I157 B:B:T159 12.93413.04NoYes079
4B:B:I157 B:B:I171 13.06462.94NoNo076
5B:B:I123 B:B:I171 13.19565.89YesNo066
6B:B:I123 B:B:Y111 13.11594.84YesYes1164
7B:B:N110 B:B:Y111 15.09713.49NoYes044
8B:B:N110 B:B:S108 15.36898.94NoNo046
9B:B:G109 B:B:S108 15.50541.86NoNo056
10B:B:G109 B:B:Y105 15.64272.9NoYes056
11B:B:L69 B:B:Y105 19.35725.86NoYes056
12B:B:R68 B:B:Y85 21.2521.61NoNo054
13B:B:Y85 G:G:F61 21.07853.09NoYes348
14B:B:N340 G:G:F61 21.56588.46YesYes398
15B:B:N340 G:G:L50 22.9952.75YesNo099
16B:B:M45 G:G:L50 1005.65NoNo049
17B:B:L308 B:B:M45 59.85494.24NoNo074
18B:B:C294 B:B:L308 19.91377.94NoNo057
19B:B:C294 B:B:V315 19.91235.12NoNo057
20B:B:H311 B:B:V315 19.91252.77YesNo097
21B:B:D333 B:B:H311 99.63255.04YesYes999
22B:B:D312 B:B:D333 99.390510.65NoYes959
23B:B:D312 R:R:K38 99.29986.91NoNo055
24R:R:K38 R:R:L39 97.99212.82NoNo058
25R:R:L39 R:R:N44 97.63354.12NoYes088
26R:R:N44 R:R:T43 38.2432.92YesNo088
27R:R:D105 R:R:T43 26.2585.78YesNo1098
28R:R:D105 R:R:F46 22.31424.78YesYes1097
29B:B:L308 B:B:W339 40.000128.47NoYes079
30B:B:T329 B:B:W339 39.88158.49NoYes089
31B:B:H311 B:B:T329 40.07955.48YesNo098
32B:B:M45 B:B:V327 40.26153.04NoYes046
33B:B:V327 B:B:W339 40.11643.68YesYes069
34B:B:K337 B:B:W339 40.17378.12YesYes969
35B:B:H311 B:B:K337 39.908515.72YesYes996
36R:R:T43 R:R:Y116 11.85124.99NoYes1087
37A:A:W281 B:B:W332 15.76554.69NoYes459
38A:A:F246 A:A:F273 12.201610.72YesYes099
39R:R:F297 R:R:N44 59.31456.04YesYes088
40R:R:F297 R:R:N294 43.57943.62YesNo088
41A:A:Y391 R:R:N294 43.44633.49NoNo048
42A:A:Y391 R:R:R106 43.315911.32NoNo049
43R:R:R106 R:R:Y193 23.38318.23NoYes199
44B:B:D323 B:B:K280 72.88112.77YesNo071
45B:B:K280 G:G:D48 72.75514.15NoYes019
46G:G:D48 G:G:L51 72.385.43YesYes096
47B:B:V40 G:G:L51 71.88512.98YesYes036
48B:B:R283 B:B:V40 71.40312.62YesYes093
49B:B:D323 B:B:M325 77.09478.32YesYes375
50B:B:S201 B:B:W211 17.48164.94YesYes598
51B:B:F199 B:B:W211 11.184115.03YesYes598
52B:B:R283 G:G:C41 65.63572.79YesNo097
53B:B:F235 G:G:C41 65.51454.19YesNo067
54B:B:F235 G:G:Y40 36.01635.16YesYes766
55B:B:N237 G:G:Y40 35.545213.96NoYes056
56B:B:G238 B:B:N237 35.25933.39NoNo075
57B:B:F234 B:B:G238 35.19893.01YesNo057
58B:B:F234 B:B:V200 11.97516.55YesYes256
59B:B:I232 B:B:V200 10.00794.61YesYes286
60B:B:F234 B:B:F241 23.04333.22YesYes256
61B:B:I232 B:B:T243 19.20279.12YesYes288
62B:B:I229 B:B:T243 25.462610.64NoYes278
63B:B:G202 B:B:I229 25.23855.29NoNo067
64B:B:F241 B:B:F253 12.54749.65YesYes266
65B:B:G202 B:B:S201 24.78863.71NoYes069
66B:B:F235 B:B:F278 29.02969.65YesYes767
67B:B:F278 B:B:L285 28.633312.18YesYes776
68B:B:L285 B:B:Y264 28.37523.52YesYes765
69B:B:W297 B:B:Y264 28.47956.75NoYes085
70B:B:W297 B:B:Y289 28.34375.79NoYes087
71B:B:I269 B:B:Y289 26.92534.84YesYes1847
72B:B:D291 B:B:I269 26.07185.6NoYes084
73B:B:C271 B:B:D291 25.95386.22NoNo058
74B:B:C271 B:B:D290 26.35956.22NoNo056
75B:B:D290 B:B:R314 26.202411.91NoNo068
76B:B:M325 G:G:P49 76.77473.35YesNo057
77R:R:F46 R:R:I102 20.64083.77YesNo078
78R:R:I102 R:R:Y290 20.50264.84NoYes089
79R:R:L99 R:R:Y290 39.95863.52YesYes089
80R:R:F244 R:R:L99 33.61063.65YesYes098
81R:R:F244 R:R:W248 43.98978.02YesYes198
82L:L:?1 R:R:W248 38.35553.81YesYes108
83R:R:R106 R:R:Y290 19.80699.26NoYes199
84R:R:M241 R:R:Y193 18.00813.59YesYes189
85R:R:F244 R:R:M241 17.11084.98YesYes198
86L:L:?1 R:R:V89 28.982513.71YesYes104
87R:R:F297 R:R:V29 15.31552.62YesYes089
88R:R:A51 R:R:V29 14.59593.39NoYes099
89R:R:A51 R:R:N26 13.88024.69NoYes099
90R:R:D54 R:R:N26 13.312916.16NoYes099
91R:R:D54 R:R:S283 13.17168.83NoNo099
92R:R:S283 R:R:V57 13.03846.46NoNo097
93R:R:M62 R:R:V57 10.35943.04YesNo077
94R:R:V89 R:R:Y173 28.64453.79YesYes147
95R:R:Y149 R:R:Y173 22.35212.98YesYes157
96R:R:H154 R:R:Y157 12.79127.62YesNo023
97R:R:H161 R:R:Y157 10.96446.53NoNo2353
98R:R:H161 R:R:P162 10.05161.53NoNo053
99B:B:R314 B:B:W332 25.893621.99NoYes089
100G:G:L50 G:G:P49 76.89083.28NoNo097
101A:A:N279 A:A:W281 15.43673.39YesNo485
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:V89 13.71 1 Yes Yes 0 4 0 1
L:L:?1 R:R:S92 7.54 1 Yes No 0 6 0 1
L:L:?1 R:R:T93 3.7 1 Yes No 0 6 0 1
L:L:?1 R:R:F167 3.06 1 Yes Yes 0 4 0 1
L:L:?1 R:R:S177 5.03 1 Yes No 0 5 0 1
L:L:?1 R:R:S181 7.54 1 Yes Yes 0 6 0 1
L:L:?1 R:R:W248 3.81 1 Yes Yes 0 8 0 1
L:L:?1 R:R:F251 14.27 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F252 7.13 1 Yes Yes 0 7 0 1
L:L:?1 R:R:Y255 3.92 1 Yes No 0 6 0 1
L:L:?1 R:R:F276 8.15 1 Yes Yes 0 5 0 1
L:L:?1 R:R:Y280 2.94 1 Yes Yes 0 7 0 1
R:R:M62 R:R:W277 4.65 1 Yes Yes 7 4 2 2
R:R:M62 R:R:Y280 8.38 1 Yes Yes 7 7 2 1
R:R:F276 R:R:N65 3.62 1 Yes Yes 5 6 1 2
R:R:N65 R:R:W277 14.69 1 Yes Yes 6 4 2 2
R:R:N65 R:R:Y280 5.81 1 Yes Yes 6 7 2 1
R:R:F167 R:R:N85 9.67 1 Yes No 4 4 1 2
R:R:D88 R:R:Y280 8.05 0 No Yes 6 7 2 1
R:R:S140 R:R:V89 3.23 0 No Yes 7 4 2 1
R:R:F167 R:R:V89 2.62 1 Yes Yes 4 4 1 1
R:R:V89 R:R:Y173 3.79 1 Yes Yes 4 7 1 2
R:R:S92 R:R:W248 4.94 1 No Yes 6 8 1 1
R:R:S136 R:R:T93 7.99 0 Yes No 8 6 2 1
R:R:S181 R:R:T93 7.99 1 Yes No 6 6 1 1
R:R:I96 R:R:W248 11.74 0 No Yes 8 8 2 1
R:R:F167 R:R:V169 3.93 1 Yes No 4 3 1 2
R:R:V169 R:R:Y173 12.62 0 No Yes 3 7 2 2
R:R:V169 R:R:Y255 6.31 0 No No 3 6 2 1
R:R:A174 R:R:Y255 2.67 0 No No 5 6 2 1
R:R:S177 R:R:S181 3.26 1 No Yes 5 6 1 1
R:R:F252 R:R:S181 2.64 1 Yes Yes 7 6 1 1
R:R:F182 R:R:F244 6.43 1 Yes Yes 8 9 2 2
R:R:F182 R:R:W248 4.01 1 Yes Yes 8 8 2 1
R:R:F182 R:R:F252 19.29 1 Yes Yes 8 7 2 1
R:R:F244 R:R:W248 8.02 1 Yes Yes 9 8 2 1
R:R:F252 R:R:W248 8.02 1 Yes Yes 7 8 1 1
R:R:G279 R:R:W248 2.81 0 No Yes 7 8 2 1
R:R:N282 R:R:W248 7.91 0 No Yes 9 8 2 1
R:R:F251 R:R:F252 8.57 1 Yes Yes 6 7 1 1
R:R:F251 R:R:L275 4.87 1 Yes No 6 5 1 2
R:R:F251 R:R:F276 12.86 1 Yes Yes 6 5 1 1
R:R:F276 R:R:V272 2.62 1 Yes No 5 4 1 2
R:R:F276 R:R:Y280 6.19 1 Yes Yes 5 7 1 1
R:R:W277 R:R:Y280 11.58 1 Yes Yes 4 7 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
69.23Single9M55DPMF9M55-Oct-Beta2-DPMF-chim(NtGi1-Gs)/β1/γ2

PDB Summary
PDB 9M57
Class A
SubFamily Amine
Type Adrenergic
SubType Oct-Beta2
Species Ixodes scapularis
Ligand Octopamine
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution 3.65
Date 2025-12-17
D.O.I. 10.1093/pnasnexus/pgaf376
Net Summary
Imin 2.62
Number of Linked Nodes 774
Number of Links 938
Number of Hubs 157
Number of Links mediated by Hubs 563
Number of Communities 23
Number of Nodes involved in Communities 223
Number of Links involved in Communities 329
Path Summary
Number Of Nodes in MetaPath 102
Number Of Links MetaPath 101
Number of Shortest Paths 2684773
Length Of Smallest Path 3
Average Path Length 39.9392
Length of Longest Path 69
Minimum Path Strength 1.265
Average Path Strength 6.07115
Maximum Path Strength 21.495
Minimum Path Correlation 0.7
Average Path Correlation 0.984253
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.96078
Average % Of Corr. Nodes 31.5188
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 51.7739
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .
CodeOTR
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeOTR
Name4-(2R-AMINO-1-HYDROXYETHYL)PHENOL
SynonymsR-OCTOPAMINE
Identifier
FormulaC8 H11 N O2
Molecular Weight153.178
SMILES
PubChem440266
Formal Charge0
Total Atoms22
Total Chiral Atoms1
Total Bonds22
Total Aromatic Bonds6

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>9M57_Chain_A
EKAEKIEKQ QKDKQYRAT HRLLLLGGK NTIVKQSGI FETKFQVDK 
VNFHMFDVD ERRKWIQCF NDVTAIIFV ASSNRLALK LFDSIWNNK 
WLRDTSVIL FLNKQDLLA EKVRAKYFI RDEFLRIST AHYCYPHFT 
ENIRRVFND CRDIIQRMH LRQYELLSA DAVRSMIIT CRSIEI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>9M57_Chain_B
EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT RRTLRGHLA 
KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA IPLRSSWVM 
TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR ELAGHTGYL 
SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG HTGDVMSLS 
LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES DINAICFFP 
NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG ITSVSFSKS 
GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC LGVTDDGMA 
VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>9M57_Chain_G
LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL LTPVPASEN 
PFRE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtB7Q337
Sequence
>9M57_Chain_R
LKLVLKTLA LVTIISSAV FGNLLVVTS VIRHHKLRI TTNYFIVSL 
ALADTLVAL FAMTFNASV TISGRWLFN QTVCDFWNS CDVLFSTAS 
IMHLCCISV DRYYAIIKP LEYPTKITG RTVAIMLTC AWVSSGLIS 
FIPIFLGWY TTNEHLVYK VEHPDECIF VVNKPYAII SSSVSFWIP 
CCIMLFTYW RIYVEATRQ EKMLCKAAK TLGIIMGAF ILCWLPFFL 
WYVSITMLV VDLLFWIGY LNSSLNPVI YAYFNREFR QAFKETLQA 
I


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9M55AAmineAdrenergicOct-Beta2Ixodes scapularisDPMF-chim(NtGi1-Gs)/β1/γ23.392025-12-1710.1093/pnasnexus/pgaf376
9M55 (No Gprot) AAmineAdrenergicOct-Beta2Ixodes scapularisDPMF-3.392025-12-1710.1093/pnasnexus/pgaf376
9M57AAmineAdrenergicOct-Beta2Ixodes scapularisOctopamine-chim(NtGi1-Gs)/β1/γ23.652025-12-1710.1093/pnasnexus/pgaf376
9M57 (No Gprot) AAmineAdrenergicOct-Beta2Ixodes scapularisOctopamine-3.652025-12-1710.1093/pnasnexus/pgaf376




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