Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg. Int. Strength Num. Of Links Community ConSurf
1G.HN.45 1.2375404
2G.H1.01 5.5054179
3G.H1.08 3.93408
4G.S2.03 5.285419
5G.S2.05 4.02167403
6G.S2.08 6.59254185
7G.S3.03 7.28583407
8G.S3.04 5.53467516
9G.S3.06 6.47867515
10G.s3h2.03 5.146519
11G.H2.06 4.89056619
12G.H2.07 4.31167619
13G.H2.09 5.20833418
14G.H2.10 3.71167417
15G.h2s4.01 4.83333819
16G.S4.02 3.498334168
17G.S4.04 5.00667409
18G.s4h3.04 5.18667568
19G.s4h3.05 4.91569
20G.H3.01 3.42067509
21G.H3.03 3.14583464
22G.H3.09 5.69267509
23G.H3.17 5.14467505
24G.H3.18 4.191674169
25G.S5.05 3.483896199
26G.hgh4.01 5.33167466
27G.hgh4.02 4.745667
28G.hgh4.05 8.03917407
29G.H4.10 8.48083466
30G.H4.15 4.69167608
31G.h4s6.02 5.498334128
32G.S6.02 6.23083407
33G.s6h5.04 1.85583408
34G.H5.08 5.01254188
35G.H5.20 4.34167409
36b.1x2 2.1225401
37b.lhb1x3 3.08402
38b.lhb1x6 4.883334133
39b.l1x3 8.01889639
40b.b2x1 6.44467518
41b.b2x5 5.14056637
42b.l3x2 4.65333539
43b.b4x5 3.91417487
44b.b4x6 9.05833639
45b.l4x2 11.5558434
46b.b5x2 4.81833407
47b.b5x3 6.12267509
48b.b5x5 4.95083485
49b.b5x7 4.35167487
50b.l5x1 3.492588
51b.l5x5 6.87762719
52b.b6x5 4.19417406
53b.l6x5 6.0954144
54b.b7x1 6.020834144
55b.b7x4 3.00417488
56b.l7x2 3.515419
57b.b8x3 3.48406
58b.b8x4 3.93524786
59b.l8x8 4.18167484
60b.b9x4 6.50083409
61b.l9x3 6.25222619
62b.l9x6 4.2237918
63b.b10x5 4.26067509
64b.l10x1 3.85167403
65b.l11x2 8.78583419
66b.b12x6 7.13095718
67b.b13x7 7.12267597
68b.l13x3 8.322599
69b.l13x6 4.185419
70b.b14x3 3.85667405
71b.b15x1 7.50583499
72b.l15x1 4.99583417
73b.l15x2 5.556599
74b.b16x4 9.38667496
75b.b16x6 8.64867598
76b.b17x5 5.71167447
77b.b17x7 6.78448
78b.l17x3 7.59649
79b.l17x6 5.61733519
80b.b18x3 5.60583448
81b.l18x1 5.9525156
82b.l18x2 4.849174157
83b.b19x2 5.32944646
84b.b19x4 4.17548
85b.l19x2 4.85449
86b.b20x4 9.44333548
87b.b20x6 6.02267546
88b.b21x1 7.08867547
89b.b21x2 3.21417406
90b.b21x5 5.20917474
91b.b21x7 5.28389675
92b.l21x2 5.37417404
93b.l21x7 3.71833475
94b.b22x5 5.1545157
95b.l22x5 7.125139
96b.b23x1 3.74417405
97b.b23x6 5.90476777
98b.b24x4 6.01417476
99b.b24x5 3.38417405
100b.l25x3 7.3645109
101b.l27x1 11.7856619
102b.l27x2 6.981674109
103b.b28x2 5.2075404
104b.b28x3 3.52417407
105b.b28x4 5.726674106
106b.b28x6 7.775335109
107g.h1x1 1.54667502
108g.l1x4 5.83448
109g.ctx3 5.43067509
110g.ctx6 3.021116136
111g.ctx14 5.24083439
112g.ctx16 4.07238738
1131x52 2.035406
1141x57 1.94254117
115I1x50 4.453338118
1162x41 5.3325454
1172x42 4.63067558
1182x46 4.02417459
1192x49 3.459174228
1202x50 5.33833659
1212x57 3.59083407
1222x63 6.01167425
123E1x50 7.88267528
1243x28 5.27333625
1253x32 8.91428
1263x41 5.736674236
1273x42 5.12083407
1283x44 3.431674236
1293x51 5.334508
1303x52 6.765404
131I2x53 9.43667458
1324x38 7.24658
1334x57 2.96167408
134E2.E191 3.88733523
135E2x50 5.76667429
1365x36 3.31867506
1375x47 7.28111628
1385x48 3.85933505
1395x50 5.244174239
1405x58 4.116509
1415x68 5.68083407
1426x48 7.02944628
1436x49 3.80833406
1446x51 5.38667427
1456x52 8.35467526
1466x55 5.25333427
1477x39 5.00267526
1487x42 5.64619727
1497x47 3.57133506
1507x48 3.14417406
1517x49 5.30917459
1527x53 5.17333559
1538x50 7.351116118
154Lig 7.059721220
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1b.b3x2 b.b4x6 17.87274.55333NoYes359
2b.b2x5 b.b3x2 18.39087.21333YesNo375
3b.b2x5 b.l26x1 38.217710.51YesNo377
4b.l26x1 b.l26x3 38.72966.26667NoNo377
5b.l26x3 b.l26x5 39.7717.85667NoNo075
6b.l26x5 g.ctx4 40.28855.59NoNo057
7g.ctx3 g.ctx4 40.80583.75667YesNo097
8g.ctx3 g.ctx6 43.84956.33333YesYes096
9b.l22x5 g.ctx6 51.53483.64333YesYes1396
10b.l22x5 b.lhb1x3 27.83012.92333YesYes092
11b.h2x5 b.lhb1x3 28.83494.56NoYes052
12b.h2x1 b.h2x5 57.64982.95NoNo055
13b.b21x5 b.h2x1 59.33815.65333YesNo045
14b.b21x5 b.b21x7 60.28038.38333YesYes745
15b.b21x7 b.b24x6 88.65288.36YesNo758
16b.b23x6 b.b24x6 88.63894.5YesNo778
17b.b23x6 b.l21x7 92.20883.58333YesYes775
18b.l21x7 b.l23x1 93.62783.11YesNo056
19b.l23x1 b.l25x6 10021.0433NoNo068
20G.H3.17 b.l25x6 60.26653.07YesNo058
21G.H2.09 G.H3.17 51.46157.32333YesYes085
22G.H2.09 G.H2.10 67.57073.44YesYes187
23G.H2.10 G.h2s4.01 84.0892.79333YesYes179
24G.H2.07 G.h2s4.01 81.88122.67YesYes199
25G.H2.07 b.l9x6 44.63163.21667YesYes198
26b.b10x1 b.l9x6 28.33752.54333NoYes098
27b.b10x1 b.b11x5 28.00912.71667NoNo096
28b.b11x5 b.b14x3 22.05024.00333NoYes065
29b.b10x2 b.b14x3 14.5635.28667NoYes065
30b.b10x2 b.b10x4 13.55623.71333NoNo066
31b.b10x4 b.b2x4 12.898713.9167NoNo066
32b.b2x4 b.b6x5 12.57123.63333NoYes066
33b.b6x5 b.b7x2 11.56022.52333YesNo068
34b.l22x5 b.l24x2 27.82149.31333YesNo096
35b.h2x5 b.l24x2 28.5752.94667NoNo056
36b.l25x6 b.l27x1 40.461223.3233NoYes089
37G.H2.09 b.l27x1 17.29853.17667YesYes189
38b.b2x1 b.l27x1 23.38816.11YesYes189
39G.H2.10 b.b2x1 17.12794.03333YesYes178
40G.H3.15 G.H3.17 48.65733.89667NoYes085
41G.H3.15 G.H3.18 48.59973.62333NoYes089
42G.H2.08 G.H3.18 48.20653.76667NoYes089
43G.H2.07 G.H2.08 48.14992.74YesNo098
44G.H3.16 G.H3.17 93.44074.64NoYes045
45G.H3.16 G.h3s5.01 93.38693.88NoNo043
46G.h3s5.01 G.h3s5.02 93.28096.11333NoNo034
47G.h3s5.02 G.h4s6.10 93.22663.59NoNo043
48G.H5.21 G.h4s6.10 93.0657.23NoNo053
49G.H5.18 G.H5.21 12.89633.21333NoNo045
50G.H5.14 G.H5.18 12.72522.42333NoNo074
51G.H5.14 G.S6.02 12.38274.08667NoYes077
52G.H5.10 G.S6.02 10.67123.11NoYes067
53G.H5.10 G.S5.03 10.4983.25NoNo068
54G.S5.03 G.S5.05 10.15132.51333NoYes089
55G.H3.01 G.s1h1.03 10.14960.793333YesNo098
56G.H3.01 G.s4h3.05 20.08487.54333YesYes099
57G.s4h3.04 G.s4h3.05 25.22786.13YesYes689
58G.HG.15 G.s4h3.04 16.84964.69NoYes078
59G.HG.15 G.hgh4.02 25.27973.97NoYes077
60G.H4.11 G.hgh4.02 74.76552.83667NoYes077
61G.H4.11 G.H4.15 80.58442.51NoYes078
62G.H4.15 G.S4.06 27.93857.43YesNo087
63G.S4.04 G.S4.06 28.21072.62YesNo097
64G.H3.08 G.S4.04 91.33514.87333NoYes099
65G.H2.04 G.H3.08 91.58664.86NoNo099
66G.H2.04 G.H2.07 92.09574NoYes099
67G.hgh4.01 G.s4h3.04 16.83374.92667YesYes668
68G.hgh4.01 G.hgh4.02 18.51888.73667YesYes667
69G.s4h3.05 G.s4h3.15 12.6123.59YesNo099
70G.H3.03 G.s4h3.15 13.45673.82667YesNo049
71G.H3.03 G.hgh4.02 19.19583.02YesYes647
72G.H3.09 G.H4.15 28.03997.14667YesYes098
73G.H3.09 G.S4.04 31.58059.28667YesYes099
74G.H4.15 G.S5.04 27.95672.84333YesNo089
75G.S4.04 G.S5.04 31.29943.24667YesNo099
76G.S4.07 G.s4h3.05 15.22542.21667NoYes689
77G.H4.10 G.hgh4.02 10.15775.71667YesYes667
78G.H5.20 G.H5.26 87.60866.82333YesNo095
79G.H5.21 G.H5.26 88.55852.41NoNo055
803x50 G.H5.23 87.120310.68NoNo094
81G.H5.23 G.H5.25 87.19052.11667NoNo047
82G.H5.20 G.H5.25 87.33052.30667YesNo097
83b.b20x5 b.b21x7 26.91063.52NoYes075
84b.b20x5 b.b21x4 26.64893.69333NoNo075
85b.b20x7 b.b21x4 26.3874.52333NoNo095
86b.b20x7 b.l20x3 25.86284.63NoNo097
87b.b21x2 b.l20x3 25.60042.52667YesNo067
88b.1x19 b.b21x2 24.81243.5NoYes066
89b.1x19 b.b21x1 15.575811.91NoYes067
90b.l11x1 b.l9x6 17.38895.31333NoYes198
91b.b11x6 b.l11x1 17.09293.71NoNo199
92b.b11x6 b.l9x3 15.067313.9467NoYes199
93b.b12x6 b.l9x3 12.38654.23333YesYes189
94b.b17x7 b.b21x1 13.40973.98YesYes487
957x39 7x42 11.71177.07333YesYes267
963x36 6x48 33.14.35NoYes268
976x48 7x45 70.24069.41667YesNo089
987x45 7x49 71.47929.99NoYes099
992x46 7x49 35.76794.20667YesYes599
1002x46 7x53 40.03693.99YesYes599
1013x50 7x53 74.55314.11333NoYes599
1027x42 Lig 12.90662.54YesYes270
1033x36 Lig 25.91648.28NoYes260
1046x52 Lig 26.12198.82333YesYes260
1056x48 6x52 32.00495.68YesYes286
1063x43 7x49 35.55023.44667NoYes089
1073x43 7x53 35.66145.05NoYes089
1082x37 2x39 10.16722.88NoNo078
1092x39 4x38 10.34697.20667NoYes588
1102x42 3x49 14.21373.61667YesNo589
1112x42 3x46 15.36563.80333YesNo589
1123x46 3x50 12.49495.42667NoNo599
1133x28 Lig 12.82225.94333YesYes250
1145x39 5x43 11.092411.02NoNo076
1155x43 Lig 12.77885.38333NoYes060
116b.b2x5 b.l4x1 17.31523.70667YesNo375
117b.l4x1 g.ctx16 10.48384.4NoYes358
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
2x563x326.813332NoYes7821
2x567x423.792NoYes7721
2x577x425.586670YesYes7721
2x593x287.213330NoYes5521
2x603x283.706672NoYes6521
2x607x393.706672NoYes6622
2x607x425.086672NoYes6721
2x63E1x508.463332YesYes5822
2x633x285.292YesYes5521
3x28E1x506.873332YesYes5812
E1x50E2x5010.44672YesYes8922
3x28E2x502.613332YesYes5912
3x29E2x502.726670NoYes6922
3x29E2x523.073330NoNo6421
3x323x362.593332YesNo8611
3x327x429.196672YesYes8711
3x32Lig17.03672YesYes8010
3x334x573.770NoYes7812
3x33Lig8.156670NoYes7010
3x366x484.352NoYes6812
3x36Lig8.282NoYes6010
3x374x535.863330NoNo7812
3x375x4613.360NoNo7712
3x37Lig3.956670NoYes7010
E2x52Lig4.553330NoYes4010
5x395x4311.020NoNo7621
5x43Lig5.383330NoYes6010
5x446x524.756670NoYes6621
5x476x485.682YesYes8822
5x476x5219.29332YesYes8621
6x486x525.682YesYes8621
6x516x523.222YesYes7611
6x516x556.216672YesYes7711
6x517x383.653332YesNo7511
6x51Lig8.456672YesYes7010
6x52Lig8.823332YesYes6010
6x55Lig5.692YesYes7010
7x387x426.252NoYes5711
7x38Lig5.896672NoYes5010
7x397x427.073332YesYes6721
7x42Lig2.542YesYes7010
3x28Lig5.943332YesYes5010
6x55E2.R1965.813332YesNo7012
5x446x553.293330NoYes6721
4x565x432.066670NoNo6621

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
100.00Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
91.67Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
91.67Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
91.67Consensus5ht5_onOrthosteric Ligand5ht5a_on
91.67Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
84.62Single5JQHS-Carazolol5JQH-β2-S-Carazolol
84.62Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
84.62Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
84.62Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
84.62Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
84.62Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
84.62Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
84.62Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
84.62Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
84.62Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
84.62Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
83.33Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
83.33Single6PS0S-Carazolol6PS0-β2-S-Carazolol
83.33Single6PS4ICI118-5516PS4-β2-ICI118-551
83.33Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
83.33Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
83.33Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
78.57Single6H7JIsoprenaline6H7J-β1-Isoprenaline
78.57Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
78.57Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
78.57Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
78.57Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
78.57Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
78.57Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
78.57Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
76.92Single2Y04Salbutamol2Y04-β1-Salbutamol
76.92Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
76.92Single3NY8ICI118-5513NY8-β2-ICI118-551
76.92Single4GBRS-Carazolol4GBR-β2-S-Carazolol
76.92Single6H7MSalbutamol6H7M-β1-Salbutamol
76.92Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
76.92Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
76.92Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
76.92Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
76.92Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
76.92Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
76.92Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
76.92Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
76.92Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
76.92Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
76.92Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
76.92Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
76.92Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
76.92Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
76.92Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
76.92Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
76.92Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
76.92Consensusdopamine_offOrthosteric Ligandd2_off d3_off
76.92Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
76.92Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
75.00Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
75.00Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
75.00Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
75.00Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
75.00Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
75.00Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
75.00Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
75.00Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
75.00Consensusalpha2_offOrthosteric Ligandalpha2c_off
73.33Single3D4STimolol3D4S-β2-Timolol
73.33Single4AMIBucindolol4AMI-β1-Bucindolol
73.33Single4LDEBI1671074LDE-β2-BI167107
73.33Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
73.33Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
73.33Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
73.33Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
73.33Single8JJ8Formoterol8JJ8-β2-Formoterol
73.33Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
73.33Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
73.33Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
71.43Single2RH1S-Carazolol2RH1-β2-S-Carazolol
71.43Single2Y03Isoprenaline2Y03-β1-Isoprenaline
71.43Single2YCWS-Carazolol2YCW-β1-S-Carazolol
71.43Single5D6LS-Carazolol5D6L-β2-S-Carazolol
71.43Single5TVNLSD5TVN-5-HT2B-LSD
71.43Single5X7DS-Carazolol5X7D-β2-S-Carazolol-PubChem 129318963
71.43Single6E67BI1671076E67-β2-BI167107-Gs (fused)
71.43Single7WC6LSD7WC6-5-HT2A-LSD
71.43Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
71.43Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
71.43Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
71.43Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
71.43Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
71.43Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
71.43Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
71.43Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
71.43Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
71.43Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
71.43Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
71.43Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
71.43Consensusamine_offonOrthosteric Ligandamine_off amine_on
71.43Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
71.43Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
71.43Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
71.43Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
71.43Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
71.43Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
69.23Single6KUXRS-799486KUX-α2a-RS-79948
69.23Single6PS5S-Propranolol6PS5-β2-S-Propranolol
69.23Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
69.23Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
69.23Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
69.23Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
69.23Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
69.23Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
69.23Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
69.23Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
69.23Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
69.23Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
69.23Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
69.23Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
69.23Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
69.23Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
69.23Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
69.23Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
69.23Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
69.23Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
69.23Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
69.23Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
69.23Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
69.23Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
69.23Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
69.23Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
69.23Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
69.23Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
69.23Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
69.23Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
69.23Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
69.23Consensusalpha1_onOrthosteric Ligandalpha1a_on
69.23Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
69.23Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
69.23Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
69.23Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
69.23Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
68.75Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
68.75Single6H7LDobutamine6H7L-β1-Dobutamine
68.75Single6IBLArformoterol6IBL-β1-Arformoterol
68.75Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
68.75Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
68.75Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
68.75Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
66.67Single2YDVNECA2YDV-A2A-NECA
66.67Single3P0GBI1671073P0G-β2-BI167107
66.67Single3PBLEticlopride3PBL-D3-Eticlopride
66.67Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
66.67Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
66.67Single4UHRCGS216804UHR-A2A-CGS21680
66.67Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
66.67Single5D5AS-Carazolol5D5A-β2-S-Carazolol
66.67Single5D5BS-Carazolol5D5B-β2-S-Carazolol
66.67Single5G53NECA5G53-A2A-NECA-Gs
66.67Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
66.67Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
66.67Single6WGTLSD6WGT-5-HT2A-LSD
66.67Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
66.67Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
66.67Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
66.67Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
66.67Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
66.67Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
66.67Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
66.67Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
66.67Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
66.67Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
66.67Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
66.67Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
66.67Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
66.67Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
66.67Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
66.67Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
64.29Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
64.29Single2Y01Dobutamine2Y01-β1-Dobutamine
64.29Single2Y02Carmoterol2Y02-β1-Carmoterol
64.29Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
64.29Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
64.29Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
64.29Single4QKX35V4QKX-β2-35V
64.29Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
64.29Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
64.29Single6PS1Timolol6PS1-β2-Timolol
64.29Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
64.29Single7BU7BI1671077BU7-β1-BI167107
64.29Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
64.29Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
64.29Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
64.29Single7WC7Lisuride7WC7-5-HT2A-Lisuride
64.29Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
64.29Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
64.29Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
64.29Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
64.29Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
64.29Single8JJOAlprenolol8JJO-β2-Alprenolol
64.29Single8JXRLSD8JXR-D1-LSD
64.29Single8PJKST1718PJK-5-HT1A-ST171-t7m-Gi1/β1/γ1
64.29Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
64.29Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
64.29Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
64.29Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
64.29Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
64.29Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
64.29Single9CHXS-Carazolol9CHX-β2-S-Carazolol
64.29Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
64.29Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
64.29Consensusalpha2_onOrthosteric Ligandalpha2b_on
64.29Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
64.29Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
64.29Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
64.29Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
64.29Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
62.50Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
62.50Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
62.50Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
62.50Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
62.50Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
62.50Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
62.50Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
62.50Single8JJLOlodaterol8JJL-β2-Olodaterol
62.50Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
62.50Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
62.50Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
62.50Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
62.50Consensusalpha1_offOrthosteric Ligandalpha1a_off
62.50Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
62.50Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
62.50Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
62.50Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
61.54Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
61.54Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
61.54Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
61.54Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
61.54Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
61.54Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
61.54Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
61.54Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
61.54Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
61.54Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
61.54Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
61.54Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
61.54Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
61.54Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
61.54Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
61.54Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
61.54Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
61.54Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
61.54Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
61.54Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
61.54Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
61.54Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
61.54Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
61.11Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
61.11Single4IARErgotamine4IAR-5-HT1B-Ergotamine
61.11Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
61.11Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
60.00Single2Y00Dobutamine2Y00-β1-Dobutamine
60.00Single5C1MBU725C1M-μ-BU72
60.00Single5WIUNemonapride5WIU-D4-Nemonapride
60.00Single5WIVNemonapride5WIV-D4-Nemonapride-Na
60.00Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
60.00Single6PS6Timolol6PS6-β2-Timolol
60.00Single7C61Ergotamine7C61-5-HT1B-Ergotamine
60.00Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
60.00Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
60.00Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
60.00Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
60.00Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
60.00Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
60.00Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
60.00Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
60.00Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
60.00Consensustrace-amine_onOrthosteric Ligandta1_on
58.82Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
58.82Single5X93K-87945X93-ETB-K-8794
58.82Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
58.82Single7UM4AS26747237UM4-5-HT5A-AS2674723
58.82Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
58.82Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
58.82Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
58.82Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
58.33Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
58.33Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
58.33Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
58.33Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
57.14Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
57.14Single6TPGEMPA6TPG-OX2-EMPA
57.14Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
57.14Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
57.14Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
57.14Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
57.14Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
57.14Single7UL3Famotidine7UL3-H2-Famotidine
57.14Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
57.14Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
57.14Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
57.14Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
57.14Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
57.14Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
57.14Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
57.14Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
57.14Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
57.14Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
57.14Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
57.14Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
57.14Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
57.14Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
57.14Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
56.25Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
56.25Single4U15Tiotropium4U15-M3-Tiotropium
56.25Single5V54Methiothepin5V54-5-HT1B-Methiothepin
56.25Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
56.25Single6J21Aprepitant6J21-NK1-Aprepitant
56.25Single6OL9Tiotropium6OL9-M5-Tiotropium
56.25Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
56.25Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
56.25Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
56.25Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
56.25Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
56.25Single8E0GBU728E0G-μ-BU72
56.25Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
56.25Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
56.25Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
56.25Single9F33FOB02-04A9F33-D3-FOB02-04A-Go1/β1/γ2
56.25Consensus5ht1_offOrthosteric Ligand5ht1b_off
56.25Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
56.25Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
56.25Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
55.56Single3NY9ICI118-5513NY9-β2-ICI118-551
55.56Single4UG2CGS216804UG2-A2A-CGS21680
55.56Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
55.56Single8X5YAstemizole8X5Y-H1-Astemizole
53.85Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
53.85Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
53.85Single7SRQLSD7SRQ-5-HT2B-LSD
53.85Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
53.85Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
53.85Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
53.85Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
53.85Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
53.85Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
53.85Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
53.85Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
53.85Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
53.85Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
53.85Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
53.85Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
53.33Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
53.33Single4EJ4Naltrindole4EJ4-δ-Naltrindole
53.33Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
53.33Single6DRXLisuride6DRX-5-HT2B-Lisuride
53.33Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
53.33Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
53.33Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
53.33Single7UL4Alvimopan7UL4-μ-Alvimopan
53.33Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
53.33Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
53.33Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
53.33Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
53.33Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
53.33Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
53.33Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
53.33Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
53.33Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
53.33Single8X64Desloratadine8X64-H1-Desloratadine
53.33Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
53.33Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
53.33Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
53.33Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
53.33Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
53.33Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
52.94Single4RWADIPP-NH24RWA-δ-DIPP-NH2
52.94Single5CXVTiotropium5CXV-M1-Tiotropium
52.94Single6MXTSalmeterol6MXT-β2-Salmeterol
52.94Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
52.94Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
52.94Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
52.94Single7YITNalfurafine7YIT-κ-Nalfurafine
52.94Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
52.94Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
52.94Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
52.94Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
52.94Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
52.94Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
52.94Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
52.94Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
52.63Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
52.63Single8PKMBefiradol8PKM-5-HT1A-Befiradol-t7m-Gi1/β1/γ1
52.63Single8WDTphotoNECA8WDT-A2A-photoNECA
52.63Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
52.63Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
50.00Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
50.00Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
50.00Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
50.00Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
50.00Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
50.00Single5WQCEMPA5WQC-OX2-EMPA
50.00Single6AKXA4R6AKX-CCR5-A4R
50.00Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
50.00Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
50.00Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
50.00Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
50.00Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
50.00Single6TODEMPA6TOD-OX1-EMPA-Na
50.00Single6TP6Filorexant6TP6-OX1-Filorexant
50.00Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
50.00Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
50.00Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
50.00Single7LD3Adenosine7LD3-A1-Adenosine-PubChem 25263603-Gi2/β1/γ2
50.00Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
50.00Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
50.00Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
50.00Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
50.00Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
50.00Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
50.00Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
50.00Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
50.00Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
50.00Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
50.00Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
50.00Single8IWESpermidine8IWE-TA9-Spermidine
50.00Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
50.00Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
50.00Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
50.00Single8ZMFA1L108ZMF-5-HT2C-A1L10
50.00Single9CHUNoradrenaline9CHU-β2-Noradrenaline
50.00Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
50.00Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
50.00Consensusa3_on_gpOrthosteric Liganda3a_on_gp
50.00Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
50.00Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
50.00Consensusendothelin_offOrthosteric Ligandetb_off
50.00Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
50.00Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
50.00Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
50.00Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
50.00Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
50.00Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
50.00Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
50.00Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
50.00Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
50.00Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
50.00Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
50.00Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
47.62Single5WF5UK-4320975WF5-A2A-UK-432097
47.62Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
47.37Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
47.37Single6PT3DPI-2876PT3-δ-DPI-287
47.37Single7SK9CCX6627SK9-ACKR3-CCX662
47.06Single4DJHJDTic4DJH-κ-JDTic
47.06Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
47.06Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
47.06Single6TQ7SB-3348676TQ7-OX1-SB-334867
47.06Single7B6WCyclazosin7B6W-α1b-Cyclazosin
47.06Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
47.06Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
47.06Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
47.06Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
47.06Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
47.06Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
47.06Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
47.06Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
47.06Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
47.06Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
47.06Single8XVLZibotentan8XVL-ETA-Zibotentan
47.06Consensusa2_onOrthosteric Liganda2b_on
47.06Consensusa2_on_gpOrthosteric Liganda2b_on_gp
47.06Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
47.06Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
47.06Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
47.06Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
47.06Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
47.06Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
47.06Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
47.06Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
47.06Consensustachykinin_offOrthosteric Ligandnk1_off
46.67Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
46.67Single2YDOAdenosine2YDO-A2A-Adenosine
46.67Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
46.67Single3RZECidoxepin3RZE-H1-Cidoxepin
46.67Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
46.67Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
46.67Single4MBSMaraviroc4MBS-CCR5-Maraviroc
46.67Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
46.67Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
46.67Single4ZJCSB-6740424ZJC-OX1-SB-674042
46.67Single6A94Zotepine6A94-5-HT2A-Zotepine
46.67Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
46.67Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
46.67Single6TPNHTL66416TPN-OX2-HTL6641
46.67Single6VI4JDTic6VI4-κ-JDTic
46.67Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
46.67Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
46.67Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
46.67Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
46.67Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
46.67Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
46.67Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
46.67Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
46.67Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
46.67Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
46.67Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
46.67Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
46.67Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
46.67Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
46.67Single8YN8Proxyfan8YN8-H3-Proxyfan-Go1/β1/γ2
46.67Single9BJKNaloxone9BJK-μ-Naloxone-NAM
46.67Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
46.67Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
46.67Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
46.67Consensusopsins_offOrthosteric Ligandrhodopsin_off
46.67Consensussensory_offOrthosteric Ligandopsins_off
46.15Single3UZAGTPL92363UZA-A2A-GTPL9236
46.15Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
46.15Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
46.15Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
46.15Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
46.15Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
46.15Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
46.15Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
46.15Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
46.15Consensus5ht2_onOrthosteric Ligand5ht2b_on
46.15Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
46.15Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
46.15Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
46.15Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
46.15Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
46.15Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
46.15Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
45.00Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
45.00Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
45.00Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
45.00Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
44.44Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
44.44Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
44.44Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
44.44Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
44.44Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
44.44Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
43.75Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
43.75Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
43.75Single4MQSIperoxo4MQS-M2-Iperoxo
43.75Single4U14Tiotropium4U14-M3-Tiotropium
43.75Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
43.75Single5DHHSB-6121115DHH-NOP-SB-612111
43.75Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
43.75Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
43.75Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
43.75Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
43.75Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
43.75Single6TOTLemborexant6TOT-OX1-Lemborexant
43.75Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
43.75Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
43.75Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
43.75Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
43.75Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
43.75Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
43.75Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
43.75Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
43.75Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
43.75Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
43.75Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
43.75Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
43.75Single8T1WCVN4248T1W-GPR6-CVN424
43.75Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
43.75Single8X63Mepyramine8X63-H1-Mepyramine
43.75Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
43.75Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
43.75Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
43.75Consensusa3_onOrthosteric Liganda3a_on
43.75Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
43.75Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
43.75Consensushistamine_offOrthosteric Ligandh1_off
43.75Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
43.75Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
43.48Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
42.86Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
42.86Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
42.86Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
42.86Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
42.86Single3QAKUK-4320973QAK-A2A-UK-432097
42.86Single6HLLCP999946HLL-NK1-CP99994
42.86Single6HLOAprepitant6HLO-NK1-Aprepitant
42.86Single6TP4ACT-4622066TP4-OX1-ACT-462206
42.86Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
42.86Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
42.86Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
42.86Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
42.86Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
42.86Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
42.86Single8YN7Immethridine8YN7-H3-Immethridine-Go1/β1/γ2
42.86Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
42.86Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
42.11Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
42.11Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
42.11Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
42.11Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
42.11Single7EZCUKA7EZC-A2A-UKA
42.11Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
42.11Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
42.11Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
42.11Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
42.11Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
42.11Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
42.11Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
42.11Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
42.11Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
42.11Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
42.11Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
42.11Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
41.67Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
41.18Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
41.18Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
41.18Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
41.18Single5XPRBosentan5XPR-ETB-Bosentan
41.18Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
41.18Single6HLPNetupitant6HLP-NK1-Netupitant
41.18Single6LUQHaloperidol6LUQ-D2-Haloperidol
41.18Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
41.18Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
41.18Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
41.18Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
41.18Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
41.18Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
41.18Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
41.18Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
41.18Single8JXSPF-61428JXS-D1-PF-6142
41.18Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
41.18Single8XYKVUF106618XYK-CXCR3-VUF10661-Go1/β1/γ2
41.18Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
41.18Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
41.18Single9F34FOB02-04A9F34-D3-FOB02-04A-Go1/β1/γ2
41.18Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
41.18Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
41.18Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
41.18Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
40.91Single6PT2KGCHM076PT2-δ-KGCHM07
40.91Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
40.91Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
40.91Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
40.00Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
40.00Single5WF6UK-4320975WF6-A2A-UK-432097
40.00Single5WS3EMPA5WS3-OX2-EMPA
40.00Single6AKYMaraviroc6AKY-CCR5-Maraviroc
40.00Single6B73MP11046B73-κ-MP1104
40.00Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
40.00Single6DS0Ly2660976DS0-5-HT2B-Ly266097
40.00Single6ME2Ramelteon6ME2-MT1-Ramelteon
40.00Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
40.00Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
40.00Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
40.00Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
40.00Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
40.00Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
40.00Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
40.00Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
40.00Single7XN9L-054,5227XN9-SST2-L-054,522
40.00Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
40.00Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
40.00Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
40.00Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
40.00Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
40.00Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ
40.00Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
40.00Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
40.00Consensusorexin_offOrthosteric Ligandox2_off ox1_off
40.00Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
40.00Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
40.00Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
40.00Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
40.00Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
39.13Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
39.13Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
38.89Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
38.89Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
38.89Single6J20Aprepitant6J20-NK1-Aprepitant
38.89Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
38.89Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
38.89Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
38.89Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
38.89Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
38.89Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
38.89Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
38.89Single8EA0Iperoxo8EA0-M3-Iperoxo
38.89Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
38.89Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
38.89Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
38.89Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
38.89Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
38.89Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
38.89Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
38.89Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
38.89Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
38.89Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
38.89Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
38.46Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
38.46Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
38.46Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
38.46Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
38.46Consensussensory_onOrthosteric Ligandopsins_on
38.10Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
38.10Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
38.10Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
38.10Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
38.10Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
38.10Consensuslpl_onOrthosteric Ligands1p_on lpa_on
38.10Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
37.50Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
37.50Single6IQLL7458706IQL-D4-L745870
37.50Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
37.50Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
37.50Single6TP3Nemorexant6TP3-OX1-Nemorexant
37.50Single6V9SGTPL114036V9S-OX1-GTPL11403
37.50Single7T94Acetylcholine7T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
37.50Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
37.50Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
37.50Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
37.50Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
37.50Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
37.50Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
37.50Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
37.50Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
37.50Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
36.84Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
36.84Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
36.84Single6A93Risperidone6A93-5-HT2A-Risperidone
36.84Single6CM4Risperidone6CM4-D2-Risperidone
36.84Single6ZG4HTL00099366ZG4-M1-HTL0009936
36.84Single7DFPSpiperone7DFP-D2-Spiperone
36.84Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
36.84Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
36.84Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
36.84Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
36.84Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
36.84Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
36.84Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
36.84Single8JWY2-1188JWY-A2A-2-118
36.84Single8JWZAB9288JWZ-A2A-AB928-Na
36.84Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
36.84Single8XYIVUF106618XYI-CXCR3-VUF10661
36.84Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
36.84Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
36.84Consensusorexin_onOrthosteric Ligandox2_on
36.84Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
36.84Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
36.84Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
36.84Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
36.36Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
36.36Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
36.36Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
36.36Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
36.36Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
36.36Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
35.71Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
35.71Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
35.71Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
35.71Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
35.71Single7WC5Psilocin7WC5-5-HT2A-Psilocin
35.71Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.71Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
35.71Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
35.71Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
35.29Single4DAJTiotropium4DAJ-M3-Tiotropium
35.29Single5DHGC-355DHG-NOP-C-35
35.29Single5DSGTiotropium5DSG-M4-Tiotropium
35.29Single5UIGCmpd-15UIG-A2A-Cmpd-1
35.29Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
35.29Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
35.29Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
35.29Single8CU6LJ-45178CU6-A2A-LJ-4517
35.29Single8RLNLUF58348RLN-A2A-LUF5834
35.29Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
35.29Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
35.29Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
35.29Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
35.29Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
35.29Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
35.29Consensusblt_onOrthosteric Ligandblt1_on
35.29Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
35.29Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
35.29Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
35.29Consensusleukotriene_onOrthosteric Ligandblt_on
35.29Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
35.29Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
35.00Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
35.00Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
35.00Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
35.00Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.00Single8T3OTUG-8918T3O-FFA4-TUG-891-2Y5-chim(NtGi2L-Gs-CtGq)/β1/γ2
35.00Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
35.00Single8XVJMacitentan8XVJ-ETA-Macitentan
35.00Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
35.00Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
34.78Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
34.78Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
34.78Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
34.78Consensusangiotensin_onOrthosteric Ligandat1_on
34.78Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
34.78Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
34.78Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
34.78Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
34.78Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
34.62Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
34.62Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
34.62Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
34.62Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
33.33Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
33.33Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
33.33Single5MZPCaffeine5MZP-A2A-Caffeine-Na
33.33Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
33.33Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
33.33Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
33.33Single5ZTYAM102575ZTY-CB2-AM10257
33.33Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
33.33Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
33.33Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
33.33Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
33.33Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
33.33Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
33.33Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
33.33Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
33.33Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
33.33Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
33.33Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
33.33Single7SINNPS-21437SIN-CaS-NPS-2143
33.33Single7SINNPS-21437SIN-CaS-NPS-2143
33.33Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
33.33Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
33.33Single7V68Iperoxo7V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
33.33Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
33.33Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
33.33Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
33.33Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
33.33Single7W41PD1762527W41-BB2-PD176252
33.33Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
33.33Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
33.33Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
33.33Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
33.33Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
33.33Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
33.33Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
33.33Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
33.33Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
33.33Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
33.33Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
33.33Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
33.33Single8K5BNiacin8K5B-HCA2-Niacin
33.33Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
33.33Single8S4DCMF-0198S4D-Apelin-CMF-019
33.33Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
33.33Single8TF5Oleic acid8TF5-GPR6-Oleic acid
33.33Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
33.33Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
33.33Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go1/β1/γ2
33.33Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
33.33Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
33.33Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
33.33Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
33.33Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
33.33Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
33.33Consensusadenosine_offOrthosteric Liganda1_off a2_off
33.33Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
33.33Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
33.33Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
33.33Consensusbombesin_offOrthosteric Ligandbb2_off
33.33Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
33.33Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
33.33Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
33.33Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
33.33Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
33.33Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
33.33Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
33.33Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
33.33Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
33.33Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
33.33Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
33.33Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
33.33Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
33.33Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
33.33Consensusvasop-oxy_onOrthosteric Ligandv2_on
33.33Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
32.14Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
32.14Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
32.14Consensusbombesin_onOrthosteric Ligandbb2_on
32.14Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
32.14Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
32.00Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
32.00Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
31.82Single7F8XNN90567F8X-CCKA-NN9056
31.82Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
31.82Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
31.82Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
31.82Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
31.82Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
31.82Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
31.82Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
31.82Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
31.58Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
31.58Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
31.58Single6E59L-7607356E59-NK1-L-760735
31.58Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
31.58Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
31.58Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
31.58Single7TUYGSK682753A7TUY-GPR183-GSK682753A
31.58Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
31.58Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
31.58Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
31.58Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
31.58Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
31.58Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
31.58Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
31.58Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
31.58Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
31.58Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
31.58Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
31.58Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
31.25Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
31.25Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
31.25Single4S0VSuvorexant4S0V-OX2-Suvorexant
31.25Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
31.25Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
31.25Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
31.25Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
31.25Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
31.25Single6ME9Ramelteon6ME9-MT2-Ramelteon
31.25Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
31.25Single6TPJSuvorexant6TPJ-OX2-Suvorexant
31.25Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
31.25Single7F8ULintitript7F8U-CCKA-Lintitript
31.25Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
31.25Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
31.25Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
31.25Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
31.25Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
31.25Single7XRRLemborexant7XRR-OX2-Lemborexant
31.25Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
31.25Single8GNGIstradefylline8GNG-A2A-Istradefylline
31.25Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
31.25Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
31.25Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
31.25Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
31.25Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
31.25Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
31.25Single8Y0HVUF114188Y0H-CXCR3-VUF11418
31.25Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
31.25Consensusangiotensin_offOrthosteric Ligandat1_off
31.25Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
31.25Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
31.25Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
30.77Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
30.77Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
30.77Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
30.77Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
30.77Single7WC4Serotonin7WC4-5-HT2A-Serotonin
30.77Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
30.77Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Single8PWNTheophylline8PWN-A2A-Theophylline
30.77Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
30.43Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
30.43Single7CUMPhospholipid7CUM-GABAB1, GABAB2-CGP54626-Phospholipid
30.43Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
30.43Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
30.43Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
30.43Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
30.00Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
30.00Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
30.00Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
30.00Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
30.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
30.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
30.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
30.00Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
30.00Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
30.00Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
30.00Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
30.00Single8JD3HZR; PEF8JD3-mGlu2; mGlu3-Glutamate-HZR; PEF-Gi1/β1/γ2
30.00Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
30.00Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
30.00Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
30.00Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
30.00Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
30.00Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
30.00Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
30.00Consensuslpa_offOrthosteric Ligandlpa1_off
30.00Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
30.00Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
29.63Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
29.63Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
29.63Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
29.63Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
29.41Single3REYXAC3REY-A2A-XAC
29.41Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
29.41Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
29.41Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
29.41Single5IU7Q274563465IU7-A2A-Q27456346-Na
29.41Single5IUBQ274563445IUB-A2A-Q27456344-Na
29.41Single5JTBZM-2413855JTB-A2A-ZM-241385
29.41Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
29.41Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
29.41Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
29.41Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
29.41Single6AQFZM-2413856AQF-A2A-ZM-241385
29.41Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
29.41Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
29.41Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
29.41Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
29.41Single7AROLUF58337ARO-A2A-LUF5833-Na
29.41Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
29.41Single7F61PF-036547467F61-H3-PF-03654746-Cholesterol
29.41Single7T32ZM-2413857T32-A2A-ZM-241385
29.41Single7VODCariprazine7VOD-5-HT2A-Cariprazine
29.41Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
29.41Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
29.41Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
29.41Single8IHKAcifran8IHK-HCA3-Acifran
29.41Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
29.41Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
29.41Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
29.41Single8K5CAcipimox8K5C-HCA2-Acipimox
29.41Single8K9LDamgo8K9L-μ-Damgo-VV9-Gi3/β1/γ1
29.41Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
29.41Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
29.41Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
29.41Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
29.41Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
29.41Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.41Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
29.41Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
29.41Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
29.41Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
29.41Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
29.41Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
29.41Consensusa2_offOrthosteric Liganda2a_off
29.41Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
29.41Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
29.41Consensushca_onOrthosteric Ligandhca2_on
29.17Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
29.17Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
28.57Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
28.57Single3RFMCaffeine3RFM-A2A-Caffeine
28.57Single6K1QIRL25006K1Q-ETB-IRL2500
28.57Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
28.57Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
28.57Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
28.57Single8A2OTheophylline8A2O-A2A-Theophylline-Na
28.57Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
28.57Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
28.57Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
28.57Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
28.57Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
28.57Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
28.57Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
28.57Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(CtGi1-G13)/β1/γ2
28.57Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
28.57Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
28.57Consensusbradykinin_onOrthosteric Ligandbk2_on
28.57Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
28.57Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
28.57Consensuscck_onOrthosteric Ligandccka_on cckb_on
28.57Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
28.57Consensuschemerin_onOrthosteric Ligandcml1_on
28.57Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
28.57Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
28.57Consensusprostanoid_offOrthosteric Ligandep_off dp_off
28.00Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
28.00Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
28.00Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
28.00Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
28.00Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
27.78Single3EMLZM-2413853EML-A2A-ZM-241385
27.78Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
27.78Single4YAYZD-71554YAY-AT1-ZD-7155
27.78Single5IU8Q274563475IU8-A2A-Q27456347-Na
27.78Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
27.78Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
27.78Single5UENDU1725UEN-A1-DU172
27.78Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
27.78Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
27.78Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
27.78Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
27.78Single6S0LZM-2413856S0L-A2A-ZM-241385
27.78Single6XBM25(S)-Epoxycholesterol6XBM-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
27.78Single7PYRPSB-21157PYR-A2A-PSB-2115
27.78Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
27.78Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
27.78Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
27.78Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
27.78Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
27.78Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
27.78Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
27.78Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
27.78Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
27.78Single8K5DGSK2560738K5D-HCA2-GSK256073
27.78Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
27.78Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
27.78Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
27.78Single9IYAONO-97105319IYA-GPR55-ONO-9710531
27.78Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
27.78Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
27.78Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
27.78Consensushca_on_gpOrthosteric Ligandhca2_on_gp
27.78Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
27.78Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
27.59Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
27.27Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
27.27Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
27.27Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
27.27Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
27.27Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
27.27Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
27.27Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
27.27Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
27.27Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
27.27Consensuskisspeptin_onOrthosteric Ligandkiss1_on
26.92Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
26.92Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
26.92Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
26.67Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
26.67Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
26.67Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
26.67Single6ME5Agomelatine6ME5-MT1-Agomelatine
26.67Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
26.67Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
26.67Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
26.67Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.67Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
26.67Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
26.67Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
26.67Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
26.67Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
26.67Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
26.67Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
26.67Consensusgi_sensoryOrthosteric Ligandgi_opsins
26.67Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
26.67Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
26.32Single4NTJAZD12834NTJ-P2Y12-AZD1283
26.32Single5CGCHTL142425CGC-mGlu5-HTL14242
26.32Single5IUAQ274563485IUA-A2A-Q27456348-Na
26.32Single5N2RPSB-365N2R-A2A-PSB-36-Na
26.32Single5N2SPSB365N2S-A1-PSB36
26.32Single6D26Fevipiprant6D26-DP2-Fevipiprant
26.32Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
26.32Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
26.32Single6S0QZM-2413856S0Q-A2A-ZM-241385
26.32Single6W2XPubChem 237279706W2X-GABAB1, GABAB2-PubChem 5311042-PubChem 23727970
26.32Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
26.32Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
26.32Single7C4SS1P7C4S-S1P3-S1P
26.32Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
26.32Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
26.32Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
26.32Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
26.32Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
26.32Single8GNEKW-63568GNE-A2A-KW-6356-Na
26.32Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
26.32Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
26.32Single8QOTNanobody-E8QOT-μ-Nanobody-E
26.32Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
26.32Single8WGBW9R8WGB-mGlu4; mGlu2-Glutammate-W9R-Gi3/β1/γ2
26.32Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
26.32Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
26.32Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
26.32Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
26.32Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
26.32Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
26.32Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
26.32Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
26.32Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
26.32Consensusdp_offOrthosteric Liganddp2_off
26.32Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
26.32Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
26.32Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
26.09Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
26.09Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
26.09Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
26.09Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
26.09Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
26.09Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.09Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
26.09Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
26.09Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
26.09Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
25.93Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
25.93Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
25.93Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
25.81Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
25.81Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
25.00Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
25.00Single5XR8AM8415XR8-CB1-AM841
25.00Single5XRAAM115425XRA-CB1-AM11542
25.00Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
25.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
25.00Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
25.00Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
25.00Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
25.00Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
25.00Single7PX4PSB-21137PX4-A2A-PSB-2113
25.00Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
25.00Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
25.00Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
25.00Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
25.00Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
25.00Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
25.00Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
25.00Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
25.00Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
25.00Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
25.00Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
25.00Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
25.00Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
25.00Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
25.00Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
25.00Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
25.00Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
25.00Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
25.00Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
25.00Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
25.00Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
25.00Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
25.00Single9GE2ML1849GE2-GPR55-ML184-Cholesterol-chim(CtGi1-G13)/β1/γ2
25.00Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
25.00Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
25.00Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
25.00Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
25.00Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
25.00Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
25.00Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
25.00Consensuslpa_onOrthosteric Ligandlpa1_on
25.00Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
25.00Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
25.00Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
24.14Single6IGLIRL16206IGL-ETB-IRL1620
24.14Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
24.14Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
24.14Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
24.00Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
24.00Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
24.00Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
24.00Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
24.00Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
24.00Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
23.81Single4N4WSANT-14N4W-SMO-SANT-1
23.81Single6W2YPubChem 237279706W2Y-GABAB1; GABAB1-PubChem 5311042-PubChem 23727970
23.81Single7K15MKD0467K15-BLT1-MKD046-Na
23.81Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
23.81Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
23.81Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
23.81Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
23.81Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
23.81Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
23.81Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
23.81Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
23.81Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
23.81Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
23.81Consensuslpl_offOrthosteric Ligands1p_off lpa_off
23.53Single3PWHZM-2413853PWH-A2A-ZM-241385
23.53Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
23.53Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
23.53Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
23.53Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
23.53Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
23.53Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.53Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
23.53Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
23.53Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
23.53Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
23.53Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
23.53Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
23.53Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-chim(NtGi1-Gq)/β1/γ2
23.53Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.53Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
23.53Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
23.53Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
23.53Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
23.53Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
23.33Single5GLHEndothelin-15GLH-ETB-Endothelin-1
23.33Single6IGKEndothelin-36IGK-ETB-Endothelin-3
23.33Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
23.08Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
23.08Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
23.08Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
23.08Single6JODAngiotensin II6JOD-AT2-Angiotensin II
23.08Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
23.08Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
23.08Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
23.08Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
23.08Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
23.08Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
23.08Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
23.08Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
23.08Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
22.73Single5CGDHTL142425CGD-mGlu5-HTL14242
22.73Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
22.73Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
22.73Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.73Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
22.73Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
22.73Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
22.73Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
22.73Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
22.73Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
22.73Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
22.58Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
22.58Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
22.22Single5UVIZM-2413855UVI-A2A-ZM-241385
22.22Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
22.22Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
22.22Single6MH8ZM-2413856MH8-A2A-ZM-241385
22.22Single6TPKRetosiban6TPK-OT-Retosiban
22.22Single6ZG9GSK10347026ZG9-M1-GSK1034702
22.22Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
22.22Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
22.22Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
22.22Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
22.22Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
22.22Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
22.22Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
22.22Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
22.22Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
22.22Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
22.22Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
22.22Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
22.22Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
22.22Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.22Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
22.22Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
22.22Single8ZRTET-18ZRT-ETB-ET-1
22.22Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Cholesterol-Gi1/β1/γ2
22.22Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
22.22Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
22.22Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
22.22Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
22.22Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
22.22Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
22.22Consensusvasop-oxy_offOrthosteric Ligandot_off
21.74Single5EE7MK08935EE7-Glucagon-MK0893
21.74Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
21.74Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
21.74Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
21.74Single8QJ2pN1628QJ2-MC4-pN162-Gs
21.74Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
21.74Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
21.74Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
21.43Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
21.43Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
21.43Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
21.43Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
21.43Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
21.43Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
21.43Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
21.21Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
21.05Single5TGZAM65385TGZ-CB1-AM6538
21.05Single6D27CAY104716D27-DP2-CAY10471
21.05Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
21.05Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
21.05Single6GPSMK08126GPS-CCR2-MK0812
21.05Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
21.05Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
21.05Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
21.05Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
21.05Single7V3ZCP559407V3Z-CB1-CP55940
21.05Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
21.05Single7YXAONO-54306087YXA-S1P5-ONO-5430608
21.05Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
21.05Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
21.05Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
21.05Consensuscck_offOrthosteric Ligandccka_off
21.05Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
21.05Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
21.05Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
20.83Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
20.83Single7QA8Peptide7QA8-STE2-Peptide
20.83Single7QA8Peptide7QA8-STE2-Peptide
20.83Single8IEBA1LYA8IEB-GPR156-A1LYA
20.83Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
20.83Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
20.83Single8WKYPG-9348WKY-MC4-PG-934
20.83Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
20.83Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
20.83Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
20.83Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
20.83Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
20.83Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
20.69Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
20.69Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
20.69Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
20.69Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
20.69Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
20.69Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
20.00Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
20.00Single6GPXMK08126GPX-CCR2-MK0812
20.00Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
20.00Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
20.00Single6TQ9SB-4081246TQ9-OX1-SB-408124
20.00Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
20.00Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
20.00Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
20.00Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
20.00Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
20.00Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
20.00Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
20.00Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
20.00Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
20.00Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
20.00Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
20.00Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
20.00Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
20.00Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
20.00Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
20.00Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
20.00Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
20.00Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
20.00Single9C2FCa; Ca; Tryptophan; '6218; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '6218; PO4
20.00Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
20.00Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
20.00Consensusblt_offOrthosteric Ligandblt1_off
20.00Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
20.00Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
20.00Consensusendothelin_onOrthosteric Ligandetb_on eta_on
20.00Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
20.00Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
20.00Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
20.00Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
20.00Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
20.00Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
20.00Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
20.00Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
20.00Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
19.35Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
19.35Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
19.35Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
19.35Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
19.35Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
19.35Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
19.23Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
19.23Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
19.23Single6W25SHU91196W25-MC4-SHU9119-Ca
19.23Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
19.23Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
19.23Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
19.23Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
19.23Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
19.23Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
19.23Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
19.23Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
19.05Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
19.05Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
19.05Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
19.05Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
19.05Single7FEECP559407FEE-CB1-CP55940-ZCZ011
19.05Single7P2L4YI7P2L-mGlu5-4YI
19.05Single7R0CAVP7R0C-V2-AVP-Arrestin2
19.05Single7T9NPubChem 6440787T9N-TSH-M22 Fab-PubChem 644078-Gs/β1/γ2
19.05Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
19.05Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
19.05Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
19.05Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
19.05Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
19.05Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
19.05Single9BJKNAM9BJK-μ-Naloxone-NAM
19.05Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
19.05Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
19.05Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
19.05Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
19.05Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
19.05Consensusrelaxin_onOrthosteric Ligandrxfp4_on
19.05Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
18.75Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
18.75Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
18.75Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
18.75Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
18.75Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
18.75Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
18.75Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
18.75Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
18.52Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
18.52Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
18.52Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
18.52Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
18.52Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
18.52Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
18.52Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
18.52Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
18.52Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
18.52Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
18.52Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
18.18Single5TZYMK8666; PubChem 1270535975TZY-FFA1-MK8666; PubChem 127053597
18.18Single6KQICP559406KQI-CB1-CP55940-Org27569
18.18Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
18.18Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
18.18Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
18.18Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
18.18Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
18.18Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
18.18Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
18.18Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
18.18Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
18.18Single8XJNCloprosetnol8XJN-TP-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
17.86Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
17.86Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
17.86Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
17.86Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
17.86Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
17.86Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
17.86Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
17.86Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
17.65Single3OE9IT1t3OE9-CXCR4-IT1t
17.65Single7XP6Strychnine7XP6-T2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
17.65Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
17.65Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
17.65Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.65Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
17.65Single9B9Y7DY9B9Y-CB1-7DY
17.39Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
17.39Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
17.39Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
17.39Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
17.39Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
17.39Single8XJOU466198XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
17.39Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
17.39Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
17.39Consensustp_onOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
17.39Consensustp_on_gpOrthosteric Ligand8XJO-TP-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
17.24Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
17.24Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
17.24Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
16.67Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
16.67Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
16.67Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
16.67Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
16.67Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
16.67Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
16.67Single7BR3Elagolix7BR3-GnRH1-Elagolix
16.67Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
16.67Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
16.67Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
16.67Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
16.67Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
16.67Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
16.67Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
16.67Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
16.67Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
16.67Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
16.67Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
16.67Single8IEIA1LYA8IEI-GPR156-A1LYA
16.67Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
16.67Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
16.67Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
16.67Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
16.67Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
16.67Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
16.67Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
16.67Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
16.67Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
16.22Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
16.13Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
16.13Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
16.13Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
16.13Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
16.13Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
16.13Single8IY6Endothelin-18IY6-ETB-Endothelin-1
16.13Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
16.00Single4XT1Fractalkine4XT1-US28-Fractalkine
16.00Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
16.00Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
16.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
16.00Single8IEIA1LYA8IEI-GPR156-A1LYA
16.00Single8IEPA1LYA8IEP-GPR156-A1LYA
16.00Single8IEPA1LYA8IEP-GPR156-A1LYA
16.00Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
16.00Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
16.00Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
16.00Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single6FFIMMPEP6FFI-mGlu5-MMPEP
15.79Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
15.79Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
15.79Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
15.79Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
15.79Single8ZPMAMD0708ZPM-CXCR4-AMD070-Cholesterol
15.79Single8ZPNAMD31008ZPN-CXCR4-AMD3100-Cholesterol
15.79Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
15.79Consensusgrh_offOrthosteric Ligandgnrh1_off
15.62Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
15.38Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
15.38Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
15.38Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
15.38Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
15.38Single8IEBA1LYA8IEB-GPR156-A1LYA
15.38Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
15.38Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
15.38Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
15.38Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
15.15Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
15.15Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
15.15Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
15.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
15.00Single6FFHFenobam6FFH-mGlu5-Fenobam
15.00Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
15.00Single6IIVDaltroban6IIV-TP-Daltroban
15.00Single7F83PF-051904577F83-Ghrelin-PF-05190457
15.00Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
15.00Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.00Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
15.00Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
15.00Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
15.00Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
15.00Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
15.00Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
15.00Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
14.81Single3OE0CVX153OE0-CXCR4-CVX15
14.81Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
14.81Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
14.81Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
14.81Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
14.81Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
14.81Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
14.71Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
14.71Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
14.29Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
14.29Single5T1APubChem 68764898; PubChem 120931705T1A-CCR2-PubChem 68764898; PubChem 12093170
14.29Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
14.29Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
14.29Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
14.29Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
14.29Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
14.29Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
14.29Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
14.29Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
14.29Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
14.29Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
14.29Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
14.29Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
14.29Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
14.29Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
14.29Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
14.29Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
14.29Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ22
14.29Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
14.29Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
14.29Consensusep_offOrthosteric Ligandep4_off
14.29Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
14.29Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
13.89Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
13.79Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
13.79Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
13.79Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
13.79Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
13.79Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
13.79Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
13.79Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
13.79Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
13.64Single5TZRMK86665TZR-FFA1-MK8666
13.64Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
13.64Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
13.64Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
13.64Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
13.64Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
13.64Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
13.64Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
13.64Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
13.64Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
13.64Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
13.33Single4XT3Fractalkine4XT3-US28-Fractalkine
13.33Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
13.33Single6FJ3PTH6FJ3-PTH1-PTH
13.33Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
13.33Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
13.33Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
13.33Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
13.33Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
13.33Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
13.33Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
13.33Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
13.33Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
13.33Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
13.04Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
13.04Single5X33BIIL2605X33-BLT1-BIIL260
13.04Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
13.04Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
13.04Single6IIURamatroban6IIU-TP-Ramatroban
13.04Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
13.04Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
13.04Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
13.04Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
13.04Single8SZHCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZH-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi1/β1/γ2
13.04Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
13.04Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
13.04Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
13.04Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
13.04Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
13.04Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
12.90Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
12.90Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
12.90Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
12.90Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
12.90Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
12.90Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
12.90Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
12.82Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
12.50Single3OE8IT1t3OE8-CXCR4-IT1t
12.50Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
12.50Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
12.50Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
12.50Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
12.50Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
12.50Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
12.50Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
12.50Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
12.50Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
12.50Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
12.50Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
12.50Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
12.12Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
12.00Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
12.00Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.00Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
12.00Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
12.00Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
12.00Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
12.00Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
12.00Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single3OE6IT1t3OE6-CXCR4-IT1t
11.76Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
11.76Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
11.76Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
11.76Single9AUCCalcitonin gene-related peptide-19AUC-CT-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
11.54Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
11.54Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
11.54Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single8KIGSHU91198KIG-MC3-SHU9119-Ca
11.54Single8U4OCXCL128U4O-CXCR4-CXCL12-Cholesterol-Gi1/β1/γ2
11.54Consensussomatostatin_offOrthosteric Ligandsst2_off
11.43Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
11.43Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
11.43Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
11.43Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.11Single5L7IVismodegib5L7I-SMO-Vismodegib
11.11Single6LI0C176LI0-GPR52-C17
11.11Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
11.11Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
11.11Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
11.11Single7SK5CXCL127SK5-ACKR3-CXCL12
11.11Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
11.11Single7XNACYN1548067XNA-SST2-CYN154806
11.11Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
11.11Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW
11.11Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab-Cholesterol
11.11Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
11.11Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
11.11Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
10.71Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
10.71Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
10.71Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
10.71Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
10.71Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
10.71Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
10.53Single3ODUIT1t3ODU-CXCR4-IT1t
10.53Single5U09Taranabant5U09-CB1-Taranabant
10.53Single5ZKQABT-4915ZKQ-PAF-ABT-491
10.53Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
10.53Single7F8YDevazepide7F8Y-CCKA-Devazepide
10.53Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.53Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
10.53Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
10.53Single8U4PAMD31008U4P-CXCR4-AMD3100-Cholesterol-Gi1/β1/γ2
10.53Single9BA0A1AKN9BA0-CB1-A1AKN
10.53Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
10.34Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
10.34Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
10.00Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
10.00Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
10.00Single7UTZPubChem 6440787UTZ-TSH-TR1402-PubChem 644078-Gs/β1/γ2
10.00Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
10.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
10.00Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
10.00Single8IYXYL-3658IYX-GPR34-YL-365
10.00Single8K2WAMG4878K2W-CXCR3-AMG487
10.00Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
10.00Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
10.00Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
10.00Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
9.68Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
9.68Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
9.68Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
9.52Single4QIMANTA XV4QIM-SMO-ANTA XV
9.52Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
9.52Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
9.52Single9B9ZA1AKO9B9Z-CB1-A1AKO
9.38Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
9.09Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
9.09Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
9.09Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
9.09Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
9.09Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
9.09Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
9.09Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
9.09Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
9.09Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
8.82Single7RBTTirzepatide7RBT-GIP-Tirzepatide-PubChem 163183774-chim(NtGi1-Gs)/β1/γ2
8.70Single5V56TC1145V56-SMO-TC114
8.70Single7F1TMIP-1a7F1T-CCR5-MIP-1a
8.70Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
8.70Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
8.70Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
8.70Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
8.70Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Cholesterol-Gi1/β1/γ1
8.70Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
8.57Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
8.57Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
8.57Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
8.33Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
8.33Single4PY02MeSATP4PY0-P2Y12-2MeSATP
8.33Single4XEENeurotensin4XEE-NTS1-Neurotensin
8.33Single4XESNeurotensin4XES-NTS1-Neurotensin
8.33Single6OS2TRV0266OS2-AT1-TRV026
8.33Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
8.33Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
8.33Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
8.33Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
8.11Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
8.00Single4BUONeurotensin4BUO-NTS1-Neurotensin
8.00Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
8.00Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
8.00Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
8.00Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7
8.00Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-PubChem 118610427-chim(NtGi1-Go)/β1/γ2
7.69Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
7.69Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
7.69Single8XQJJN2418XQJ-Apelin-JN241
7.69Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
7.69Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
7.69Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
7.41Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
7.41Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
7.41Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
7.41Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
7.41Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
7.14Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
7.14Single7SHEPI; PE7SHE-GPR158-PI; PE
7.14Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
7.14Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
7.14Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
7.14Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
6.90Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
6.90Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
6.90Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
6.90Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
6.67Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
6.45Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
6.25Single7SK3CXCL127SK3-ACKR3-CXCL12
6.25Single7V68PubChem 576644067V68-M4-Iperoxo-PubChem 57664406-Gi1/β1/γ2
6.25Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
6.25Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
6.25Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
6.25Single8SZICa; Ca; Tryptophan; Cinacalcet; PO4; PCW8SZI-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; PCW-Gi3/β1/γ2
6.06Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
6.06Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
5.88Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
5.88Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
5.56Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
5.56Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
5.56Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
5.56Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
5.26Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.26Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
5.26Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
5.26Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
5.26Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
5.26Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
5.26Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
5.26Consensusgq_nucleotideOrthosteric Ligandgq_p2y
5.26Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
5.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
5.00Single4XNVBPTU4XNV-P2Y1-BPTU
5.00Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
5.00Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
5.00Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
5.00Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
5.00Single7WV9ZCZ0117WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
5.00Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
5.00Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
4.76Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
4.76Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
4.76Single6ZINSR486926ZIN-NTS1-SR48692
4.76Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
4.76Single7T94PubChem 576644067T94-M2-Acetylcholine-PubChem 57664406-chim(NtGi1-Go)/β1/γ2
4.76Single7VV6C48/807VV6-MRGPRX2-C48/80
4.76Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
4.76Single8JD6N-(3-chlorophenyl)pyridine-2-carboxamide8JD6-mGlu4; mGlu4-Phosphoserine-N-(3-chlorophenyl)pyridine-2-carboxamide-Gi3/β1/γ2
4.76Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
4.55Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
4.55Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
4.55Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
4.55Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
4.55Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
4.55Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
4.55Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
4.35Single4JKVTaladegib4JKV-SMO-Taladegib
4.35Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
4.35Single6Z4SSR486926Z4S-NTS1-SR48692
4.35Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
4.35Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
4.17Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
4.17Single4BV0Neurotensin4BV0-NTS1-Neurotensin
4.17Single5V57TC1145V57-SMO-TC114
4.17Single6OS1TRV0266OS1-AT1-TRV026
4.17Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
4.17Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
4.17Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
4.17Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.17Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.17Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.17Single8JD5BQI; HZE; PEF8JD5-mGlu2; mGlu4-Glutamate-BQI; HZE; PEF-Gi1/β1/γ2
4.17Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Consensusneurotensin_onOrthosteric Ligandnts1_on
4.17Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
4.00Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
4.00Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
4.00Single6YVRNTS8-136YVR-NTS1-NTS8-13
4.00Single7SHEPI; PE7SHE-GPR158-PI; PE
4.00Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
4.00Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-PubChem 118610427; GDP; Mg-Gq; GRK2
4.00Single8XQJJN2418XQJ-Apelin-JN241
4.00Single8ZPLHF511168ZPL-CXCR4-HF51116-Cholesterol
4.00Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
4.00Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
4.00Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
4.00Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
4.00Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
3.85Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
3.85Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
3.85Single8JPFNeurotensin8JPF-NTS1-Neurotensin-PubChem 118610427
3.85Single8XVUCXCL28XVU-CXCR2-CXCL2
3.85Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
3.85Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.85Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.70Single6KNMJN241-96KNM-Apelin-JN241-9
3.70Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
3.70Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
3.57Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
3.57Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.57Single8XWNCXCL88XWN-CXCR2-CXCL8
3.45Single7SHFPI; PE7SHF-GPR158-PI; PE-B5; RGS7

Consensus Members
Id Members
7X5H 7X5H-5-HT5A-5-CT-Gi1/β1/γ2
7UM6 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
7UM7 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
Net Summary
Imin 2.46333
Number of Linked Nodes 870
Number of Links 1041
Number of Hubs 154
Number of Links mediated by Hubs 599
Number of Communities 24
Number of Nodes involved in Communities 209
Number of Links involved in Communities 298
Path Summary
Number Of Nodes in MetaPath 118
Number Of Links MetaPath 117
Number of Shortest Paths 2399328
Length Of Smallest Path 3
Average Path Length 30.3494
Length of Longest Path 55
Minimum Path Strength 0.495
Average Path Strength 5.33317
Maximum Path Strength 23.6533
Minimum Path Correlation 0.7
Average Path Correlation 0.985269
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.38095
Average % Of Corr. Nodes 39.7437
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 44.9995
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
5ht5_on_gp5ht5a_on_gp



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