Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Y37 8.245114
2A:A:H41 5.3675446
3A:A:L43 3.9475447
4A:A:L46 2.945458
5A:A:S51 2.962549
6A:A:K53 4.826549
7A:A:I207 3.475419
8A:A:V214 3.846546
9A:A:F219 4.985848
10A:A:F222 8.815617
11A:A:Q227 4.58833619
12A:A:E230 6.13519
13A:A:R232 4.6075418
14A:A:K233 6.1719
15A:A:W234 6.07619
16A:A:C237 3.86667618
17A:A:F238 5.96429719
18A:A:I244 4.08508
19A:A:I245 4.308547
20A:A:F246 3.85667659
21A:A:L266 5.635458
22A:A:Q267 4.585404
23A:A:L270 4.865406
24A:A:F273 4.16759
25A:A:I276 3.346558
26A:A:W277 10.248556
27A:A:W281 7.65333615
28A:A:L282 5.9525409
29A:A:I288 6.206549
30A:A:F290 5.88649
31A:A:L291 2.828558
32A:A:N292 4.34509
33A:A:L296 5.674166
34A:A:F312 5.318558
35A:A:F315 7.28167656
36A:A:Y318 5.94833656
37A:A:P321 3.94455
38A:A:E330 7.37453
39A:A:D331 7.085404
40A:A:V334 6.7875404
41A:A:R336 6.84455
42A:A:Y339 6.21167653
43A:A:F340 8.846557
44A:A:R342 5.14167654
45A:A:E344 5.9075455
46A:A:F345 5.14658
47A:A:S349 4.6025457
48A:A:Y358 3.572544
49A:A:Y360 6.62748
50A:A:H362 7.075449
51A:A:F363 8.7925455
52A:A:T364 7.7375449
53A:A:N371 7.695449
54A:A:R373 5.295445
55A:A:V375 2.7075449
56A:A:F376 6.52167648
57A:A:R385 7.796545
58A:A:L388 4.555408
59A:A:Y391 6.152534
60A:A:L393 3.45408
61B:B:L14 5.2185178
62B:B:I18 3.31407
63B:B:R22 5.505406
64B:B:L30 5.72405
65B:B:V40 3.18333683
66B:B:R48 3.8725417
67B:B:R49 6.46417
68B:B:H54 8.28619
69B:B:L55 5.79254116
70B:B:K57 9.344519
71B:B:I58 4.5975419
72B:B:Y59 6.31167618
73B:B:W63 4.70625817
74B:B:L69 4.2125405
75B:B:V71 4.028518
76B:B:Q75 7.605419
77B:B:D76 5.835119
78B:B:L79 4.0425417
79B:B:I80 7.3775418
80B:B:I81 3.875407
81B:B:W82 7.845819
82B:B:D83 6.7675408
83B:B:S84 5.1275415
84B:B:K89 6.92619
85B:B:I93 4.2375407
86B:B:L95 4.225418
87B:B:W99 6.78375819
88B:B:M101 5.52419
89B:B:Y105 4.98143716
90B:B:S108 4.59406
91B:B:Y111 4.3075414
92B:B:C114 3.176518
93B:B:G115 1.856519
94B:B:G116 2.685419
95B:B:L117 3.11619
96B:B:D118 5.5175419
97B:B:C121 2.308518
98B:B:I123 3.9516
99B:B:Y124 5.246516
100B:B:L126 3.8125415
101B:B:E138 3.6875416
102B:B:H142 5.815619
103B:B:Y145 6.4225818
104B:B:L146 3.196517
105B:B:C148 3.8575466
106B:B:C149 3.3975418
107B:B:R150 6.6466
108B:B:F151 4.19286719
109B:B:I157 4.05167617
110B:B:T159 4.00286719
111B:B:S160 3.838566
112B:B:S161 5.785419
113B:B:C166 3.392568
114B:B:A167 3.5725414
115B:B:W169 6.91429718
116B:B:T178 4.055464
117B:B:F180 6.692567
118B:B:H183 5.85333669
119B:B:G185 1.775415
120B:B:D186 5.005619
121B:B:V187 3.194569
122B:B:L190 4.2125465
123B:B:A193 3.415414
124B:B:L198 3.65413
125B:B:F199 4.26857769
126B:B:V200 5.5025416
127B:B:S201 3.91469
128B:B:C204 2.90667617
129B:B:K209 9.402566
130B:B:L210 6.838515
131B:B:W211 7.56768
132B:B:C218 3.4075465
133B:B:Q220 8.362517
134B:B:F222 8.386518
135B:B:H225 7.64286719
136B:B:D228 6.76167619
137B:B:I229 5.3725417
138B:B:I232 4.24667618
139B:B:F234 3.7875815
140B:B:F235 8.48716
141B:B:P236 7.4475417
142B:B:N237 7.228515
143B:B:G238 3.04417
144B:B:N239 8.6425412
145B:B:F241 6.23429716
146B:B:T243 5.412518
147B:B:G244 3.6275415
148B:B:S245 5.85419
149B:B:D246 6.33519
150B:B:D247 7.32519
151B:B:C250 3.482518
152B:B:R251 12.61418
153B:B:L252 4.36407
154B:B:F253 6.45833616
155B:B:D258 8.7517
156B:B:Q259 4.20254146
157B:B:L261 6.905405
158B:B:M262 6.8525404
159B:B:Y264 6.494505
160B:B:I269 2.38414
161B:B:I273 6.2575416
162B:B:T274 4.965418
163B:B:V276 2.046516
164B:B:F278 6.50667617
165B:B:R283 7.814589
166B:B:G288 2.3275417
167B:B:Y289 6.40167617
168B:B:D290 5.7575416
169B:B:C294 5.0375415
170B:B:N295 8.04416
171B:B:W297 8.004518
172B:B:L300 4.452586
173B:B:K301 4.2925405
174B:B:R304 4.9825415
175B:B:H311 9.198519
176B:B:R314 9.75167618
177B:B:C317 2.975417
178B:B:L318 3.87167616
179B:B:G319 2.46415
180B:B:T321 5.456517
181B:B:D323 6.89417
182B:B:G324 2.814519
183B:B:W332 9.33143719
184B:B:D333 8.065419
185B:B:L336 4.17833617
186B:B:K337 7.66516
187B:B:I338 3.94515
188B:B:W339 7.7619
189E:E:L37 6.78428
190E:E:C40 3.60333629
191E:E:F44 13.092529
192E:E:M48 8.174529
193E:E:W56 13.1814727
194E:E:E61 9.6526
195E:E:F62 9.774528
196E:E:Y65 8.64825
197E:E:Y66 8.63875829
198E:E:F69 6.91714728
199E:E:T73 5.95429
200E:E:E76 8.8775426
201E:E:V80 5.688505
202E:E:Q90 3.92529
203E:E:I93 5.925429
204E:E:I96 6.346526
205E:E:H97 5.13143729
206E:E:F101 11.212529
207E:E:V106 6.01424
208E:E:D113 4.1825479
209E:E:P114 4.69679
210E:E:M133 4.08439
211E:E:V137 3.12439
212E:E:R140 8.605408
213G:G:V16 2.58407
214G:G:I25 3.65412
215G:G:R27 4.975418
216G:G:V30 3.02754148
217G:G:Y40 8.315416
218G:G:D48 6.28167619
219G:G:V54 5.125416
220G:G:E58 7.03415
221G:G:F61 6.515818
222L:L:T6 5.32333630
223L:L:C7 5.4575400
224L:L:F15 4.616500
225L:L:S34 4.23754100
226L:L:T36 6.5420
227L:L:P37 3.5375420
228R:R:Q52 12.5375426
229R:R:Y53 14.91421
230R:R:Y56 9.55623
231R:R:Y71 10.305423
232R:R:W76 8.14333628
233R:R:D77 5.4625429
234R:R:W79 6.43857726
235R:R:L80 6.386525
236R:R:W82 5.44556929
237R:R:T85 3.658527
238R:R:C95 3.696529
239R:R:P96 5.68833629
240R:R:Y98 5.02667624
241R:R:F99 4.67525
242R:R:D101 7.27404
243R:R:F102 4.20875824
244R:R:D103 4.86403
245R:R:V108 3.94167627
246R:R:K110 10.7275428
247R:R:W118 10.206529
248R:R:H121 8.60254104
249R:R:Y131 6.18825
250R:R:Y146 10.524222
251R:R:Y149 6.89254235
252R:R:H156 6.7325407
253R:R:T162 3.8406
254R:R:L163 3.984538
255R:R:F170 5.434128
256R:R:F173 6.386676157
257R:R:Q179 7.0025437
258R:R:R180 5.21539
259R:R:V181 4.834129
260R:R:L183 4.8075438
261R:R:H184 5.778509
262R:R:K185 3.43754126
263R:R:M187 3.47438
264R:R:F188 4.395408
265R:R:T190 5.3425439
266R:R:Y191 6.74429738
267R:R:P216 4.6154254
268R:R:F224 4.145405
269R:R:Y228 5.698538
270R:R:M230 3.456536
271R:R:C232 5.4925438
272R:R:N233 7.175439
273R:R:Y234 8.275637
274R:R:F235 6.235435
275R:R:W236 7.21375839
276R:R:M237 3.97833639
277R:R:E240 4.43509
278R:R:I242 4.1407
279R:R:Y243 6.27143738
280R:R:H245 10.254268
281R:R:T246 3.2975437
282R:R:I248 5.105407
283R:R:V249 3.98254266
284R:R:F253 7.072546
285R:R:Q257 5.86535
286R:R:L259 6.37435
287R:R:Y262 4.08375837
288R:R:Y263 4.512535
289R:R:L265 3.78637
290R:R:W267 5.99833639
291R:R:F269 4.725633
292R:R:P270 3.622539
293R:R:H277 8.3075407
294R:R:R281 8.47667677
295R:R:F285 7.76576
296R:R:D287 6.08473
297R:R:W290 9.68167679
298R:R:S292 3.53474
299R:R:L297 4.4025474
300R:R:H302 7.142506
301R:R:P304 4.575439
302R:R:L309 2.965437
303R:R:F313 6.05406
304R:R:L316 4.6054139
305R:R:L352 5.8785139
306R:R:G353 2.0275439
307R:R:I354 6.4154136
308R:R:Q355 6.388538
309R:R:F356 5.46556937
310R:R:P363 6.73437
311R:R:Y372 5.996537
312R:R:Y374 5.3225496
313R:R:M376 4.86333637
314R:R:I380 4.076536
315R:R:H381 6.362509
316R:R:Q383 5.87639
317R:R:G384 3.575439
318R:R:F385 4.5925405
319R:R:Y391 7.61408
320R:R:C392 3.724509
321R:R:F393 3.295408
322R:R:N395 7.5525439
323R:R:E397 7.45439
324R:R:T401 5.14254157
325R:R:Q405 5.56754154
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:D83 B:B:L69 10.9732.71YesYes085
2B:B:L69 B:B:Y105 16.09935.86YesYes056
3B:B:D83 B:B:R68 12.825611.91YesNo085
4B:B:R68 B:B:Y85 24.22517.49NoNo054
5B:B:Y85 G:G:F61 24.4185.16NoYes148
6B:B:S84 G:G:F61 13.64187.93YesYes158
7B:B:S84 B:B:W63 14.36174.94YesYes157
8B:B:G319 B:B:W63 35.95472.81YesYes157
9B:B:G319 B:B:L318 69.74993.42YesYes156
10B:B:L318 B:B:T329 1004.42YesNo068
11B:B:H311 B:B:T329 10010.95YesNo098
12B:B:D333 B:B:H311 1003.78YesYes199
13B:B:D312 B:B:D333 1007.98NoYes059
14B:B:D312 R:R:S175 1005.89NoNo058
15R:R:L176 R:R:S175 1003NoNo098
16R:R:F173 R:R:L176 1003.65YesNo1579
17R:R:F173 R:R:I169 1002.51YesNo078
18R:R:C392 R:R:I169 1001.64YesNo098
19R:R:C392 R:R:F170 1004.19YesYes098
20R:R:F170 R:R:H184 1003.39YesYes089
21R:R:H184 R:R:R180 18.12459.03YesYes099
22B:B:A326 G:G:F61 13.65654.16NoYes178
23B:B:A326 B:B:W63 13.78072.59NoYes177
24B:B:D312 R:R:R404 1005.96NoNo057
25R:R:Q405 R:R:R404 1005.84YesNo047
26R:R:F173 R:R:Q405 1008.2YesYes1574
27A:A:R42 A:A:T40 14.18582.59NoNo097
28A:A:N218 A:A:T40 10.63942.92NoNo047
29A:A:F222 A:A:R42 16.40615.34YesNo079
30A:A:C237 A:A:F238 12.18252.79YesYes189
31A:A:C237 B:B:Y59 31.9096.72YesYes188
32B:B:S316 B:B:Y59 29.58635.09NoYes198
33B:B:C317 B:B:S316 30.10113.44YesNo179
34B:B:G116 B:B:M101 89.09395.24YesYes199
35B:B:G115 B:B:G116 39.35762.11YesYes199
36A:A:I244 A:A:L282 86.18492.85YesYes089
37A:A:L282 A:A:N279 10013.73YesNo098
38A:A:N279 A:A:W281 1003.39NoYes085
39B:B:M101 B:B:Y145 16.16225.99YesYes198
40A:A:F246 A:A:I276 1003.77YesYes598
41A:A:I276 A:A:L282 1004.28YesYes089
42B:B:D163 B:B:T143 11.943710.12NoNo095
43A:A:Q227 B:B:Y145 11.508110.15YesYes198
44A:A:K233 B:B:Y145 13.53872.39YesYes198
45A:A:K233 B:B:D246 19.27594.15YesYes199
46B:B:R314 B:B:W332 10021.99YesYes189
47B:B:K57 B:B:W332 16.417311.6YesYes199
48A:A:I244 A:A:V287 80.72193.07YesNo086
49A:A:F246 A:A:V248 49.04112.62YesNo097
50A:A:F246 A:A:F273 79.83572.14YesYes599
51A:A:F273 A:A:V287 79.5852.62YesNo096
52A:A:F246 A:A:L289 1004.87YesNo599
53A:A:F345 A:A:V248 46.75962.62YesNo087
54A:A:F273 A:A:F345 93.38357.5YesYes598
55A:A:F345 A:A:L289 46.75848.53YesNo589
56A:A:F345 A:A:L266 86.60512.44YesYes588
57A:A:L289 A:A:L291 1002.77NoYes598
58A:A:L270 A:A:Q267 20.50596.65YesYes064
59A:A:F345 A:A:L270 95.7227.31YesYes086
60A:A:I348 A:A:L270 47.82492.85NoYes046
61A:A:F273 A:A:I348 50.10635.02YesNo094
62A:A:F312 A:A:L266 77.4899.74YesYes588
63A:A:E344 A:A:L270 1002.65YesYes056
64B:B:L318 B:B:S275 1007.51YesNo168
65B:B:S275 B:B:T274 1004.8NoYes188
66B:B:D290 B:B:T274 1002.89YesYes168
67B:B:G288 B:B:L318 1001.71YesYes176
68B:B:G288 B:B:T274 1001.82YesYes178
69A:A:W281 B:B:D290 1008.93YesYes156
70A:A:L291 A:A:R342 63.90122.43YesYes584
71A:A:F363 A:A:L291 51.35373.65YesYes558
72A:A:E330 A:A:V334 20.53685.7YesYes034
73A:A:E327 A:A:K338 10.27174.05NoNo045
74A:A:F363 A:A:K338 11.413213.65YesNo555
75A:A:E330 A:A:T335 15.97529.88YesNo534
76A:A:T335 A:A:Y339 22.82742.5NoYes543
77A:A:F363 A:A:Y339 38.79898.25YesYes553
78A:A:R342 A:A:Y339 38.79968.23YesYes543
79A:A:F312 A:A:F340 68.37424.29YesYes587
80A:A:F315 A:A:F340 10015YesYes567
81A:A:A337 A:A:F315 29.634.16NoYes086
82A:A:A337 A:A:V301 14.81521.7NoNo087
83A:A:E344 A:A:F340 1007YesYes557
84A:A:Y318 A:A:Y339 41.0722.98YesYes563
85A:A:F315 A:A:Y318 30.79323.09YesYes566
86A:A:D343 A:A:R342 21.67732.38NoYes034
87A:A:D343 A:A:Y318 20.53563.45NoYes036
88A:A:D331 A:A:R333 54.70923.57YesNo045
89A:A:F315 A:A:R333 59.25942.14YesNo565
90A:A:R333 A:A:R336 13.6864.26NoYes555
91A:A:R336 A:A:Y318 17.11256.17YesYes556
92A:A:D331 A:A:V334 10.26513.15YesYes044
93A:A:D331 A:A:L302 21.65776.79YesNo042
94A:A:F315 A:A:I308 29.62977.54YesNo067
95A:A:I308 A:A:S306 14.81494.64NoNo077
96A:A:E314 A:A:F340 56.96763.5NoYes067
97A:A:E314 A:A:P313 45.57417.86NoNo066
98A:A:A316 A:A:E309 22.78711.51NoNo024
99A:A:E309 A:A:P313 34.18061.57NoNo046
100A:A:A316 A:A:R317 11.39354.15NoNo022
101A:A:P321 A:A:Y318 10.28045.56YesYes556
102A:A:A324 A:A:Y339 11.41869.34NoYes533
103A:A:D323 A:A:P321 11.42084.83NoYes045
104A:A:D331 A:A:P332 21.65774.83YesNo041
105B:B:I18 G:G:A23 32.46341.62YesNo078
106B:B:L14 G:G:A23 28.98561.58YesNo088
107B:B:E10 B:B:L14 17.39165.3NoYes1788
108B:B:E10 G:G:V16 16.23272.85NoYes087
109B:B:L7 G:G:V16 13.9141.49NoYes087
110B:B:L192 B:B:R150 12.90554.86NoYes056
111B:B:I18 B:B:R22 19.07695.01YesYes076
112B:B:I18 G:G:R27 19.06272.51YesYes078
113B:B:D258 B:B:R22 20.7148.34YesYes076
114B:B:D258 G:G:R27 25.90198.34YesYes178
115B:B:D66 B:B:R68 11.11662.38NoNo085
116B:B:D66 B:B:L69 10.84425.43NoYes085
117B:B:C148 B:B:T102 30.11013.38YesNo068
118B:B:N125 B:B:Y111 10.15633.49NoYes044
119B:B:L146 B:B:T159 30.02914.42YesYes179
120B:B:I157 B:B:T159 10.13893.04YesYes179
121B:B:C148 B:B:S160 11.44731.72YesYes666
122B:B:L152 B:B:L192 11.53082.77NoNo035
123B:B:D290 B:B:G272 1001.68YesNo064
124B:B:G272 B:B:I273 1001.76NoYes046
125B:B:G244 B:B:I273 84.65897.05YesYes156
126B:B:G244 B:B:T243 80.68953.64YesYes158
127B:B:F222 B:B:F253 54.03927.5YesYes186
128B:B:C250 B:B:I273 17.35926.55YesYes186
129B:B:G324 B:B:V320 10.02281.84YesNo097
130B:B:C294 B:B:V315 1005.12YesNo157
131B:B:S331 B:B:V315 1004.85NoNo197
132R:R:C392 R:R:S166 1006.89YesNo099
133R:R:F188 R:R:S166 1006.61YesNo089
134R:R:F188 R:R:L163 1006.09YesYes088
135R:R:L163 R:R:Y191 1004.69YesYes388
136R:R:N233 R:R:Y191 92.586411.63YesYes398
137R:R:N194 R:R:N233 92.12364.09NoYes089
138R:R:M230 R:R:N194 91.1562.8YesNo068
139R:R:H302 R:R:M230 1005.25YesYes066
140L:L:C7 R:R:H302 1005.9YesYes006
141L:L:C7 L:L:R11 1006.96YesNo000
142L:L:K1 L:L:R11 1002.48NoNo000
143L:L:K1 R:R:S105 1006.12NoNo001
144R:R:D103 R:R:S105 1004.42YesNo031
145R:R:D103 R:R:E106 1007.8YesNo034
146R:R:C95 R:R:E106 1003.04YesNo094
147R:R:C95 R:R:P96 1003.77YesYes299
148R:R:P96 R:R:Y98 1008.34YesYes294
149R:R:A51 R:R:Y98 1002.67NoYes084
150R:R:A51 R:R:W76 1002.59NoYes088
151R:R:Q52 R:R:W76 10016.43YesYes268
152E:E:Y66 R:R:Q52 10011.27YesYes296
153E:E:F69 E:E:Y66 1006.19YesYes289
154E:E:C40 E:E:F69 1002.79YesYes298
155E:E:C40 E:E:E76 34.36483.04YesYes296
156E:E:E76 E:E:M33 58.911210.83YesNo068
157E:E:M33 E:E:V80 49.092715.22NoYes085
158R:R:A388 R:R:S166 1001.71NoNo089
159R:R:A388 R:R:L163 1003.15NoYes088
160R:R:F188 R:R:V387 1002.62YesNo089
161R:R:V387 R:R:Y191 1005.05NoYes098
162R:R:M237 R:R:Y191 1004.79YesYes398
163R:R:M237 R:R:Y234 1004.79YesYes397
164R:R:M230 R:R:Y234 1003.59YesYes367
165R:R:E240 R:R:H184 1009.85YesYes099
166R:R:E240 R:R:M187 92.57492.71YesYes098
167R:R:M187 R:R:M237 89.39442.89YesYes389
168L:L:T6 R:R:Y234 1008.74YesYes307
169L:L:T6 R:R:H302 1006.85YesYes006
170R:R:Q383 R:R:Y191 1009.02YesYes398
171R:R:F356 R:R:Q383 1004.68YesYes379
172L:L:T6 R:R:F356 1003.89YesYes307
173R:R:G384 R:R:L163 1001.71YesYes398
174R:R:G384 R:R:Q383 1001.64YesYes399
175L:L:T4 L:L:T6 1006.28NoYes300
176L:L:C7 L:L:T4 1001.69YesNo000
177R:R:W76 R:R:Y56 1009.65YesYes283
178E:E:Y66 R:R:Y56 1005.96YesYes293
179E:E:I93 R:R:Y56 73.6344.84YesYes293
180E:E:F69 E:E:I93 62.18095.02YesYes289
181E:E:F69 E:E:T73 63.819611.67YesYes289
182E:E:E76 E:E:T73 34.36477.06YesYes269
183E:E:C40 E:E:L37 34.36483.17YesYes298
184E:E:F92 E:E:L37 14.7286.09NoYes088
185E:E:L37 E:E:P38 14.7283.28YesNo085
186E:E:Y65 E:E:Y66 52.362210.92YesYes259
187E:E:F44 E:E:Y65 14.727522.69YesYes295
188E:E:F44 E:E:G41 13.09129.03YesNo097
189E:E:H97 R:R:Y56 57.27099.8YesYes293
190E:E:H97 E:E:Y65 26.18232.18YesYes295
191E:E:F44 E:E:F69 14.727517.15YesYes298
192E:E:C40 E:E:C72 24.54667.28YesNo299
193E:E:C72 E:E:T73 24.54621.69NoYes299
194E:E:A45 E:E:F44 13.09142.77NoYes259
195E:E:M48 E:E:Y65 19.63713.59YesYes295
196E:E:F62 E:E:Y66 29.453810.32YesYes289
197E:E:F62 E:E:W56 26.18152YesYes287
198E:E:W56 E:E:Y65 39.273517.36YesYes275
199E:E:F101 E:E:H97 14.72753.39YesYes299
200E:E:F101 E:E:W56 13.091413.03YesYes297
201E:E:E61 E:E:W56 49.09157.63YesYes267
202E:E:Y66 R:R:Y53 26.18364.96YesYes291
203E:E:V106 R:R:Y53 22.912711.36YesYes241
204E:E:E61 E:E:N58 19.63667.89YesNo068
205E:E:E61 E:E:S60 19.63664.31YesNo067
206E:E:C72 E:E:M75 39.27431.62NoNo091
207E:E:M75 E:E:N71 19.63714.21NoNo014
208R:R:C95 R:R:V108 1003.42YesYes297
209R:R:V108 R:R:W82 86.69883.68YesYes279
210R:R:W118 R:R:W82 27.81846.56YesYes299
211R:R:T75 R:R:W118 13.12543.64NoYes059
212E:E:P85 R:R:T75 11.48991.75NoNo095
213E:E:V106 R:R:D57 13.09315.84YesNo044
214R:R:K47 R:R:Y98 11.46864.78NoYes044
215R:R:I301 R:R:M230 15.60832.92NoYes376
216R:R:H277 R:R:I301 15.146513.26YesNo077
217R:R:H277 R:R:R281 11.020612.41YesYes077
218R:R:E240 R:R:L183 11.0725.3YesYes098
219R:R:C95 R:R:F102 68.69532.79YesYes294
220L:L:V32 R:R:F102 13.09072.62NoYes004
221L:L:V32 R:R:T132 11.45946.35NoNo006
222R:R:Q355 R:R:Q383 14.353812.8YesYes389
223R:R:H381 R:R:I380 17.45892.65YesYes096
224R:R:H377 R:R:H381 18.47049.55NoYes079
225L:L:L12 R:R:H377 12.79065.14NoNo907
226L:L:L12 L:L:L16 11.99584.15NoNo000
227R:R:H302 R:R:L298 27.212410.29YesNo066
228R:R:L298 R:R:V293 26.1632.98NoNo066
229L:L:E14 R:R:V293 25.11877.13NoNo006
230L:L:E14 L:L:R17 23.10168.14NoNo000
231L:L:R17 R:R:L291 22.05177.29NoNo006
232L:L:F15 R:R:D103 11.55042.39YesYes003
233L:L:L16 R:R:Y146 11.19262.34NoYes002
234L:L:T30 R:R:F102 13.09956.49NoYes204
235L:L:T30 R:R:D101 11.47548.67NoYes004
236L:L:L27 R:R:D101 13.10722.71NoYes004
237R:R:F102 R:R:N135 13.10543.62YesNo043
238R:R:D101 R:R:N135 11.462114.81YesNo043
239R:R:F102 R:R:W79 24.54825.01YesYes246
240L:L:T36 R:R:W79 14.72556.06YesYes206
241L:L:N31 L:L:T36 11.468114.62NoYes200
242R:R:S91 R:R:W82 31.11774.94NoYes059
243R:R:S91 R:R:T85 29.47964.8NoYes057
244R:R:P86 R:R:T85 16.39745.25NoYes227
245R:R:P86 R:R:Y71 14.757712.52NoYes223
246R:R:A87 R:R:C112 16.37591.81NoNo249
247R:R:C72 R:R:W118 11.485610.45NoYes299
248R:R:L80 R:R:P96 13.09313.14YesYes259
249R:R:L80 R:R:V108 13.08422.98YesYes257
250R:R:L80 R:R:Q93 22.89975.32YesNo256
251R:R:Q93 R:R:W82 11.46177.67NoYes269
252R:R:F94 R:R:Q93 29.45271.17NoNo036
253R:R:F94 R:R:K107 24.54398.69NoNo033
254R:R:K107 R:R:Y92 19.63512.39NoNo034
255R:R:T109 R:R:Y92 14.72641.25NoNo054
256R:R:C289 R:R:L291 13.65164.76NoNo096
257R:R:C219 R:R:C289 12.60167.28NoNo099
258R:R:C219 R:R:P216 11.55155.65NoYes094
259A:A:F222 B:B:W99 22.954920.04YesYes179
260B:B:C317 B:B:M61 33.74384.86YesNo176
261B:B:R314 B:B:T274 10010.35YesYes188
262B:B:M101 B:B:Y59 1005.99YesYes198
263B:B:D246 B:B:G272 30.70511.68YesNo094
264B:B:I232 B:B:T243 17.65357.6YesYes188
265B:B:F253 B:B:T243 59.64272.59YesYes168
266B:B:C250 B:B:Y264 12.14195.38YesYes085
267B:B:S277 B:B:V320 13.1574.85NoNo057
268B:B:G116 B:B:L146 44.03831.71YesYes197
269B:B:D258 B:B:F222 48.32228.36YesYes178
270B:B:C121 B:B:T159 10.80011.69YesYes189
271B:B:G115 B:B:T102 32.13161.82YesNo098
272B:B:G319 B:B:M61 33.65971.75YesNo156
273B:B:W332 B:B:Y59 1002.89YesYes198
274B:B:Q75 B:B:W99 16.55525.48YesYes199
275B:B:C148 B:B:L190 10.12754.76YesYes665
276B:B:H311 B:B:V315 1006.92YesNo197
277B:B:C294 B:B:G288 1003.92YesYes157
278B:B:D333 B:B:S331 1007.36YesNo199
279A:A:W281 B:B:R314 10011YesYes158
280B:B:L318 B:B:S277 13.33YesNo165
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
E:E:I123 R:R:Y299 2.42 0 No No 9 7 2 1
H:H:?501 R:R:W128 6.13 10 No No 0 5 2 2
H:H:?501 R:R:T132 6.61 10 No No 0 6 2 1
L:L:K1 R:R:S105 6.12 0 No No 0 1 0 1
L:L:K1 R:R:E294 6.75 0 No No 0 3 0 1
L:L:C2 R:R:Y299 2.69 0 No No 0 7 0 1
L:L:N3 R:R:W361 10.17 0 No No 0 4 0 1
L:L:T4 R:R:M306 4.52 3 No No 0 4 0 1
L:L:A5 R:R:F356 5.55 3 No Yes 0 7 0 1
L:L:A5 R:R:M376 4.83 3 No Yes 0 7 0 1
L:L:T6 R:R:Y234 8.74 3 Yes Yes 0 7 0 1
L:L:T6 R:R:H302 6.85 3 Yes Yes 0 6 0 1
L:L:T6 R:R:V305 3.17 3 Yes No 0 7 0 1
L:L:T6 R:R:M306 3.01 3 Yes No 0 4 0 1
L:L:T6 R:R:F356 3.89 3 Yes Yes 0 7 0 1
L:L:C7 R:R:H302 5.9 0 Yes Yes 0 6 0 1
L:L:T9 R:R:I198 4.56 0 No No 0 7 0 1
L:L:T9 R:R:H381 2.74 0 No Yes 0 9 0 1
L:L:Q10 R:R:H302 7.42 0 No Yes 0 6 0 1
L:L:L12 R:R:L148 2.77 9 No No 0 5 0 1
L:L:L12 R:R:H377 5.14 9 No No 0 7 0 1
L:L:A13 R:R:V206 1.7 0 No No 0 3 0 1
L:L:E14 R:R:S292 2.87 0 No Yes 0 4 0 1
L:L:E14 R:R:V293 7.13 0 No No 0 6 0 1
L:L:F15 R:R:D103 2.39 0 Yes Yes 0 3 0 1
L:L:F15 R:R:K141 2.48 0 Yes No 0 3 0 1
L:L:F15 R:R:L142 4.87 0 Yes No 0 2 0 1
L:L:F15 R:R:A145 2.77 0 Yes No 0 4 0 1
L:L:L16 R:R:Y146 2.34 0 No Yes 0 2 0 1
L:L:L16 R:R:Y149 3.52 0 No Yes 0 5 0 1
L:L:R17 R:R:L291 7.29 0 No No 0 6 0 1
L:L:H18 R:R:D97 2.52 24 No No 0 2 0 1
L:L:H18 R:R:P104 6.1 24 No No 0 3 0 1
L:L:S20 R:R:L142 3 22 No No 0 2 0 1
L:L:S20 R:R:Y146 6.36 22 No Yes 0 2 0 1
L:L:F23 R:R:Y146 21.66 0 No Yes 0 2 0 1
L:L:F23 R:R:Y150 4.13 0 No No 0 4 0 1
L:L:L27 R:R:D101 2.71 0 No Yes 0 4 0 1
L:L:T30 R:R:F99 6.49 2 No Yes 0 5 0 1
L:L:T30 R:R:D101 8.67 2 No Yes 0 4 0 1
L:L:T30 R:R:F102 6.49 2 No Yes 0 4 0 1
L:L:V32 R:R:F102 2.62 0 No Yes 0 4 0 1
L:L:V32 R:R:Y131 2.52 0 No Yes 0 5 0 1
L:L:V32 R:R:T132 6.35 0 No No 0 6 0 1
L:L:S34 R:R:H121 5.58 10 Yes Yes 0 4 0 1
L:L:S34 R:R:E123 5.75 10 Yes No 0 4 0 1
L:L:S34 R:R:R126 2.64 10 Yes No 0 4 0 1
L:L:T36 R:R:W79 6.06 2 Yes Yes 0 6 0 1
L:L:P37 R:R:D77 3.22 2 Yes Yes 0 9 0 1
L:L:P37 R:R:G78 2.03 2 Yes No 0 5 0 1
L:L:P37 R:R:W79 5.4 2 Yes Yes 0 6 0 1
R:R:M48 R:R:W79 2.33 2 No Yes 6 6 2 1
R:R:M48 R:R:Y98 2.39 2 No Yes 6 4 2 2
R:R:G78 R:R:W76 8.44 2 No Yes 5 8 1 2
R:R:D77 R:R:G78 1.68 2 Yes No 9 5 1 1
R:R:D77 R:R:W82 10.05 2 Yes Yes 9 9 1 2
R:R:D77 R:R:Y131 6.9 2 Yes Yes 9 5 1 1
R:R:W79 R:R:Y98 5.79 2 Yes Yes 6 4 1 2
R:R:F99 R:R:W79 6.01 2 Yes Yes 5 6 1 1
R:R:F102 R:R:W79 5.01 2 Yes Yes 4 6 1 1
R:R:W79 R:R:Y131 14.47 2 Yes Yes 6 5 1 1
R:R:L80 R:R:W82 2.28 2 Yes Yes 5 9 2 2
R:R:L80 R:R:P96 13.14 2 Yes Yes 5 9 2 2
R:R:L80 R:R:V108 2.98 2 Yes Yes 5 7 2 2
R:R:L80 R:R:Y131 8.21 2 Yes Yes 5 5 2 1
R:R:V108 R:R:W82 3.68 2 Yes Yes 7 9 2 2
R:R:S129 R:R:W82 4.94 2 No Yes 7 9 2 2
R:R:W82 R:R:Y131 1.93 2 Yes Yes 9 5 2 1
R:R:C95 R:R:P96 3.77 2 Yes Yes 9 9 2 2
R:R:C95 R:R:F102 2.79 2 Yes Yes 9 4 2 1
R:R:C95 R:R:E106 3.04 2 Yes No 9 4 2 2
R:R:C95 R:R:V108 3.42 2 Yes Yes 9 7 2 2
R:R:C134 R:R:C95 5.46 2 No Yes 9 9 2 2
R:R:P96 R:R:Y98 8.34 2 Yes Yes 9 4 2 2
R:R:F102 R:R:P96 4.33 2 Yes Yes 4 9 1 2
R:R:P96 R:R:V108 1.77 2 Yes Yes 9 7 2 2
R:R:P96 R:R:Y131 2.78 2 Yes Yes 9 5 2 1
R:R:D97 R:R:P104 4.83 24 No No 2 3 1 1
R:R:F99 R:R:Y98 6.19 2 Yes Yes 5 4 1 2
R:R:F102 R:R:F99 3.22 2 Yes Yes 4 5 1 1
R:R:D101 R:R:N135 14.81 0 Yes No 4 3 1 2
R:R:D101 R:R:T138 2.89 0 Yes No 4 2 1 2
R:R:C134 R:R:F102 5.59 2 No Yes 9 4 2 1
R:R:F102 R:R:N135 3.62 2 Yes No 4 3 1 2
R:R:D103 R:R:P104 4.83 0 Yes No 3 3 1 1
R:R:D103 R:R:S105 4.42 0 Yes No 3 1 1 1
R:R:D103 R:R:E106 7.8 0 Yes No 3 4 1 2
R:R:V108 R:R:Y131 10.09 2 Yes Yes 7 5 2 1
R:R:C134 R:R:V108 1.71 2 No Yes 9 7 2 2
R:R:H121 R:R:P122 6.1 10 Yes No 4 5 1 2
R:R:E123 R:R:H121 3.69 10 No Yes 4 4 1 1
R:R:H121 R:R:W128 19.04 10 Yes No 4 5 1 2
R:R:N124 R:R:R126 25.31 0 No No 5 4 2 1
R:R:S129 R:R:Y131 2.54 2 No Yes 7 5 2 1
R:R:F137 R:R:K141 4.96 21 No No 1 3 2 1
R:R:F137 R:R:K366 9.93 21 No No 1 3 2 2
R:R:K141 R:R:K366 4.31 21 No No 3 3 1 2
R:R:L142 R:R:Y146 11.72 22 No Yes 2 2 1 1
R:R:H377 R:R:L148 18 9 No No 7 5 1 1
R:R:Y149 R:R:Y150 4.96 23 Yes No 5 4 1 1
R:R:I153 R:R:Y149 10.88 23 No Yes 7 5 2 1
R:R:L202 R:R:Y149 8.21 23 No Yes 7 5 2 1
R:R:A152 R:R:H381 7.32 0 No Yes 7 9 2 1
R:R:I153 R:R:L202 5.71 23 No No 7 7 2 2
R:R:H156 R:R:I198 10.61 0 Yes No 7 7 2 1
R:R:H156 R:R:H381 9.55 0 Yes Yes 7 9 2 1
R:R:H226 R:R:I198 5.3 0 No No 6 7 2 1
R:R:H201 R:R:V206 2.77 0 No No 6 3 2 1
R:R:H201 R:R:L291 2.57 0 No No 6 6 2 1
R:R:P207 R:R:V206 3.53 0 No No 3 3 1 1
R:R:M230 R:R:Y234 3.59 3 Yes Yes 6 7 2 1
R:R:H302 R:R:M230 5.25 0 Yes Yes 6 6 1 2
R:R:M237 R:R:Y234 4.79 3 Yes Yes 9 7 2 1
R:R:V305 R:R:Y234 17.66 3 No Yes 7 7 1 1
R:R:L309 R:R:Y234 3.52 3 Yes Yes 7 7 2 1
R:R:F356 R:R:Y234 11.35 3 Yes Yes 7 7 1 1
R:R:G353 R:R:M237 1.75 3 Yes Yes 9 9 2 2
R:R:M237 R:R:Q383 5.44 3 Yes Yes 9 9 2 2
R:R:D287 R:R:F285 7.17 7 Yes Yes 3 6 2 2
R:R:F285 R:R:S292 3.96 7 Yes Yes 6 4 2 1
R:R:D287 R:R:S292 4.42 7 Yes Yes 3 4 2 1
R:R:C289 R:R:L291 4.76 0 No No 9 6 2 1
R:R:E294 R:R:S292 2.87 0 No Yes 3 4 1 1
R:R:L298 R:R:V293 2.98 0 No No 6 6 2 1
R:R:H302 R:R:L298 10.29 0 Yes No 6 6 1 2
R:R:L309 R:R:V305 2.98 3 Yes No 7 7 2 1
R:R:M306 R:R:P360 1.68 3 No No 4 5 1 2
R:R:G353 R:R:L309 1.71 3 Yes Yes 9 7 2 2
R:R:F356 R:R:L309 3.65 3 Yes Yes 7 7 1 2
R:R:F356 R:R:G353 3.01 3 Yes Yes 7 9 1 2
R:R:G353 R:R:Q383 1.64 3 Yes Yes 9 9 2 2
R:R:F356 R:R:Q355 7.03 3 Yes Yes 7 8 1 2
R:R:M376 R:R:Q355 2.72 3 Yes Yes 7 8 1 2
R:R:I380 R:R:Q355 2.74 3 Yes Yes 6 8 1 2
R:R:Q355 R:R:Q383 12.8 3 Yes Yes 8 9 2 2
R:R:F356 R:R:M376 2.49 3 Yes Yes 7 7 1 1
R:R:F356 R:R:I380 7.54 3 Yes Yes 7 6 1 1
R:R:F356 R:R:Q383 4.68 3 Yes Yes 7 9 1 2
R:R:F359 R:R:Y372 3.09 3 No Yes 6 7 2 2
R:R:F359 R:R:M376 3.73 3 No Yes 6 7 2 1
R:R:P360 R:R:W361 2.7 0 No No 5 4 2 1
R:R:M376 R:R:Y372 9.58 3 Yes Yes 7 7 1 2
R:R:I380 R:R:M376 5.83 3 Yes Yes 6 7 1 1
R:R:H377 R:R:H381 9.55 9 No Yes 7 9 1 1
R:R:H381 R:R:I380 2.65 0 Yes Yes 9 6 1 1
L:L:N22 R:R:P207 1.63 0 No No 0 3 0 1
L:L:A8 R:R:I380 1.62 0 No Yes 0 6 0 1
R:R:F99 R:R:P100 1.44 2 Yes No 5 4 1 2
R:R:L148 R:R:Y374 1.17 9 No Yes 5 6 1 2
E:E:Y83 R:R:R126 1.03 0 No No 6 4 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
71.43Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
70.37Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
67.86Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
67.74Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
66.67Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
66.67Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
64.29Single9BLBCagrilintide backbone (non-acylated)9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
64.29Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
62.96Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
62.07Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
61.29Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
61.29Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
60.00Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
60.00Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
58.62Single9BLWCagrilintide backbone (non-acylated)9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
57.69Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
57.58Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
57.14Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
57.14Single9BLCCagrilintide backbone (non-acylated)9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
56.67Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
56.67Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
56.25Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
54.05Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
53.33Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
53.12Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
51.72Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
51.61Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
51.43Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
50.00Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
50.00Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
50.00Consensuscalcitonin_onOrthosteric Ligandctlike_on
44.83Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
44.12Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
41.38Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
41.18Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
40.00Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
39.39Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
39.39Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
39.39Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
38.89Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
38.89Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
38.71Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
38.24Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
37.84Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
37.84Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
37.84Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
37.50Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
37.50Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
37.50Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
37.14Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
37.14Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
37.14Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
37.14Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
37.14Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
37.14Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
36.84Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
36.67Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
36.36Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
36.36Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
36.36Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
35.29Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
35.29Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
35.29Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
35.29Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
35.14Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
34.48Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
34.29Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
34.29Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
34.29Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
34.29Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
34.15Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
33.33Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
33.33Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
33.33Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
33.33Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
33.33Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
33.33Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
33.33Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
33.33Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
33.33Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
33.33Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
33.33Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
33.33Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
33.33Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
33.33Consensuspth1_onOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
33.33Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
32.56Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
32.50Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
32.43Consensuscrf1_onOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
32.43Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
32.43Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
32.35Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
32.26Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
31.71Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
31.43Single6FJ3PTH6FJ3-PTH1-PTH
31.43Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
31.43Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
31.43Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
31.43Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
31.43Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
31.43Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
31.43Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
31.25Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
31.11Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
30.95Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
30.77Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
30.77Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
30.77Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
30.77Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.77Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
30.77Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
30.56Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
30.56Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
30.56Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
30.56Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
30.56Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
30.56Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
30.56Consensusglp_onOrthosteric Ligandglp1_on glp2_on
30.56Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
30.56Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
30.00Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
30.00Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
30.00Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
30.00Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
29.73Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
29.73Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
29.73Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
29.73Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
29.73Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
29.41Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
29.41Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
29.41Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
29.41Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
29.27Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
28.95Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
28.57Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
28.57Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
28.57Consensuspac_onOrthosteric Ligandpac1_on
28.57Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
28.21Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
28.00Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
27.78Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
27.78Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
27.78Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
27.78Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
27.78Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
27.03Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
26.67Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
26.47Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
26.47Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
26.47Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
26.32Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
26.32Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
26.19Consensuspth_onOrthosteric Ligandpth1_on pth2_on
25.64Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
25.00Single5TGZAM65385TGZ-CB1-AM6538
25.00Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
25.00Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
25.00Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
24.39Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
24.32Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
23.81Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
23.68Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
23.53Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
23.33Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
23.08Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
22.86Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
22.86Single9B5YLong-Acting PTH9B5Y-PTH1-Long-Acting PTH-chim(NtGi1-Gq)/β1/γ2
22.58Single4N4WSANT-14N4W-SMO-SANT-1
22.58Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
22.58Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
22.22Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
22.22Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
21.88Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
21.88Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
21.62Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
21.43Single2YDOAdenosine2YDO-A2A-Adenosine
21.43Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
21.21Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
21.21Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
21.21Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
21.05Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
20.59Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
20.00Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
20.00Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
20.00Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
20.00Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
20.00Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
20.00Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
20.00Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
20.00Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
20.00Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
20.00Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
20.00Single8Y02Retinal8Y02-OPN1SW-Retinal-Gi1/β1/γ2
20.00Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
20.00Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
20.00Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single9B9ZA1AKO9B9Z-CB1-A1AKO
20.00Single9EE8Adenosine9EE8-A2A-Adenosine-Gs/β1/γ2
20.00Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
20.00Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
20.00Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
19.35Single2YDVNECA2YDV-A2A-NECA
19.35Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
19.35Single4UHRCGS216804UHR-A2A-CGS21680
19.35Single5G53NECA5G53-A2A-NECA-Gs
19.35Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
19.35Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
19.35Single7P2L4YI7P2L-mGlu5-4YI
19.35Single8EA0Iperoxo8EA0-M3-Iperoxo
19.35Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
19.35Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
19.35Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
19.35Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
19.35Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
19.35Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
19.35Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
19.23Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
19.23Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
18.92Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
18.92Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
18.75Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
18.75Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
18.75Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
18.75Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
18.75Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
18.75Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
18.75Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
18.75Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
18.75Single9EBIPiclidenoson9EBI-A3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
18.75Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
18.75Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
18.75Consensuslpa_offOrthosteric Ligandlpa1_off
18.75Consensuslpl_offOrthosteric Ligands1p_off lpa_off
18.52Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
18.52Single6LI0C176LI0-GPR52-C17
18.52Single9B9Y7DY9B9Y-CB1-7DY
18.42Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
18.42Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
18.18Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
18.18Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
18.18Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
18.18Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
18.18Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
18.18Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
18.18Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
17.95Single9KFKRelaxin-39KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
17.95Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
17.86Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
17.86Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
17.86Single5U09Taranabant5U09-CB1-Taranabant
17.86Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
17.86Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
17.65Single3NY9ICI118-5513NY9-β2-ICI118-551
17.65Single4UG2CGS216804UG2-A2A-CGS21680
17.65Single5WF6UK-4320975WF6-A2A-UK-432097
17.65Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
17.65Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
17.65Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
17.65Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
17.50Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
17.50Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
17.24Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
17.24Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
17.24Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
17.24Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
17.24Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Single9BA0A1AKN9BA0-CB1-A1AKN
17.24Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
17.24Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
17.14Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
17.14Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
17.14Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
17.14Single8WDTphotoNECA8WDT-A2A-photoNECA
16.67Single3QAKUK-4320973QAK-A2A-UK-432097
16.67Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
16.67Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
16.67Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
16.67Single5DSGTiotropium5DSG-M4-Tiotropium
16.67Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
16.67Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
16.67Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
16.67Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
16.67Single6HLOAprepitant6HLO-NK1-Aprepitant
16.67Single6IIVDaltroban6IIV-TXA2-Daltroban
16.67Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
16.67Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
16.67Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
16.67Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
16.67Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
16.67Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
16.67Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
16.67Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
16.67Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
16.67Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
16.67Single8T1WCVN4248T1W-GPR6-CVN424
16.67Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
16.67Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
16.67Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
16.67Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
16.67Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
16.67Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
16.67Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
16.67Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
16.67Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
16.67Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
16.67Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
16.67Consensushca_on_gpOrthosteric Ligandhca2_on_gp
16.67Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
16.22Single5WF5UK-4320975WF5-A2A-UK-432097
16.22Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
16.22Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
16.13Single4JKVTaladegib4JKV-SMO-Taladegib
16.13Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
16.13Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
16.13Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
16.13Single6PS6Timolol6PS6-β2-Timolol
16.13Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
16.13Single7LD3Adenosine7LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
16.13Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
16.13Single7SINNPS-21437SIN-CaS-NPS-2143
16.13Single7SINNPS-21437SIN-CaS-NPS-2143
16.13Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
16.13Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
16.13Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
16.13Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
16.13Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
16.13Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
16.13Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
16.13Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
16.13Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
16.13Single9CIBFCH-22964139CIB-HCA2-FCH-2296413
16.13Single9HC04YI9HC0-mGlu5-4YI
16.13Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
16.13Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
16.13Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
16.13Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
16.13Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
16.13Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.13Consensustrace-amine_onOrthosteric Ligandta1_on
16.00Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
15.79Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
15.79Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.79Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
15.79Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
15.79Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
15.79Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
15.79Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
15.79Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
15.62Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
15.62Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
15.62Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
15.62Single5V54Methiothepin5V54-5-HT1B-Methiothepin
15.62Single5V56TC1145V56-SMO-TC114
15.62Single5V57TC1145V57-SMO-TC114
15.62Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
15.62Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
15.62Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
15.62Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
15.62Single7PX4PSB-21137PX4-A2A-PSB-2113
15.62Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
15.62Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
15.62Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
15.62Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
15.62Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
15.62Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
15.62Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
15.62Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
15.62Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
15.62Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
15.62Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
15.62Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
15.62Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
15.62Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
15.62Single8ZW0PGD28ZW0-DP1-PGD2-Gs/β1/γ2
15.62Consensus5ht1_offOrthosteric Ligand5ht1b_off
15.62Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
15.62Consensusa2_onOrthosteric Liganda2b_on
15.62Consensusa2_on_gpOrthosteric Liganda2b_on_gp
15.62Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
15.62Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
15.62Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
15.62Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
15.62Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
15.62Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
15.62Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
15.62Consensusrelaxin_onOrthosteric Ligandrxfp4_on
15.62Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
15.62Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
15.62Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
15.38Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
15.38Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
15.38Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
15.38Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
15.38Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
15.38Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
15.38Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
15.15Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
15.15Single5CXVTiotropium5CXV-M1-Tiotropium
15.15Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
15.15Single6IIURamatroban6IIU-TXA2-Ramatroban
15.15Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
15.15Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
15.15Single6OS2TRV0266OS2-AT1-TRV026
15.15Single7DFPSpiperone7DFP-D2-Spiperone
15.15Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
15.15Single7K15MKD0467K15-BLT1-MKD046-Na
15.15Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
15.15Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.15Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
15.15Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
15.15Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
15.15Single8JD3JNJ-404118138JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
15.15Single8JWY2-1188JWY-A2A-2-118
15.15Single8XJNCloprosetnol8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
15.15Single9GGGI-BOP9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
15.15Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
15.15Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
15.15Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
15.00Single4XT3Fractalkine4XT3-US28-Fractalkine
15.00Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
15.00Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
15.00Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
15.00Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
14.81Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
14.81Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
14.81Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
14.81Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
14.81Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
14.81Consensusgi_sensoryOrthosteric Ligandgi_opsins
14.81Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
14.81Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
14.71Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
14.71Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
14.71Single5CGDHTL142425CGD-mGlu5-HTL14242
14.71Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
14.71Single7EZCUKA7EZC-A2A-UKA
14.71Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
14.71Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
14.71Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
14.71Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
14.71Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
14.71Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
14.71Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
14.71Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
14.71Single8XJOU466198XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
14.71Single9AS02-bromo-LSD9AS0-5-HT2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
14.71Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
14.71Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
14.71Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
14.71Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
14.71Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
14.71Consensustp_onOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
14.71Consensustp_on_gpOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
14.63Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
14.63Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
14.63Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
14.63Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
14.63Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
14.29Single5L7IVismodegib5L7I-SMO-Vismodegib
14.29Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
14.29Single5ZTYAM102575ZTY-CB2-AM10257
14.29Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
14.29Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
14.29Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
14.29Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
14.29Single7SK9CCX6627SK9-ACKR3-CCX662
14.29Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
14.29Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
14.29Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
14.29Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
14.29Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
14.29Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
14.29Single8K5BNiacin8K5B-HCA2-Niacin
14.29Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
14.29Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
14.29Single8YKDDehydroepiandrosterone8YKD-ADGRG2-Dehydroepiandrosterone-chim(NtGi1-Gs)/β1/γ2
14.29Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
14.29Single9IZASCH9002719IZA-HCA2-SCH900271-Gi1/β1/γ2
14.29Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
14.29Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
14.29Consensusbradykinin_onOrthosteric Ligandbk2_on
14.29Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
14.29Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
14.29Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
14.29Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
14.29Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
13.95Single5GLHEndothelin-15GLH-ETB-Endothelin-1
13.95Single6IGKEndothelin-36IGK-ETB-Endothelin-3
13.95Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
13.95Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
13.95Consensusbombesin_onOrthosteric Ligandbb2_on
13.95Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
13.95Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
13.95Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
13.89Single4XT1Fractalkine4XT1-US28-Fractalkine
13.89Single7QA8Peptide7QA8-STE2-Peptide
13.89Single7QA8Peptide7QA8-STE2-Peptide
13.89Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
13.89Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
13.89Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
13.89Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
13.89Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
13.89Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
13.89Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
13.89Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
13.89Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
13.79Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
13.79Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
13.79Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
13.79Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
13.79Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
13.79Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
13.79Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
13.79Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
13.79Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
13.79Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
13.79Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
13.79Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
13.79Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
13.79Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
13.79Single8IWESpermidine8IWE-TA9-Spermidine
13.79Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
13.79Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
13.79Single8Y0HVUF114188Y0H-CXCR3-VUF11418
13.79Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go/β1/γ2
13.79Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ2
13.79Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
13.79Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
13.79Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
13.79Single9EBHAdenosine9EBH-A3A-Adenosine-Gi1/β1/γ2
13.79Single9EEAAdenosine9EEA-A2A-Adenosine-Gs/β1/γ2
13.79Single9H2XA1IR19H2X-A2A-A1IR1-Na
13.79Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
13.79Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
13.79Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
13.79Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
13.79Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
13.79Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
13.79Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
13.51Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
13.51Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
13.51Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
13.51Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
13.51Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
13.51Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
13.33Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
13.33Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
13.33Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
13.33Single5IU7Q274563465IU7-A2A-Q27456346-Na
13.33Single5JTBZM-2413855JTB-A2A-ZM-241385
13.33Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
13.33Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
13.33Single6AQFZM-2413856AQF-A2A-ZM-241385
13.33Single6FFIMMPEP6FFI-mGlu5-MMPEP
13.33Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
13.33Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
13.33Single6MH8ZM-2413856MH8-A2A-ZM-241385
13.33Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
13.33Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
13.33Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
13.33Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
13.33Single7T32ZM-2413857T32-A2A-ZM-241385
13.33Single7T94Acetylcholine7T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
13.33Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
13.33Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
13.33Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
13.33Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
13.33Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
13.33Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
13.33Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
13.33Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
13.33Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
13.33Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
13.33Single8K5CAcipimox8K5C-HCA2-Acipimox
13.33Single8RLNLUF58348RLN-A2A-LUF5834
13.33Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
13.33Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
13.33Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
13.33Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
13.33Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.33Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
13.33Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
13.33Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
13.33Single9JFUNE52-QQ579JFU-GPR4-NE52-QQ57
13.33Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
13.33Consensusa2_offOrthosteric Liganda2a_off
13.33Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
13.33Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
13.33Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
13.33Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
13.33Consensushca_onOrthosteric Ligandhca2_on
13.33Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
13.33Consensusopsins_offOrthosteric Ligandrhodopsin_off
13.33Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
13.33Consensussensory_offOrthosteric Ligandopsins_off
13.16Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
13.16Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.16Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
13.16Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
13.16Single9B54A1AIW9B54-CB1-A1AIW-Gi1/β1/γ2
13.16Consensusangiotensin_onOrthosteric Ligandat1_on
13.16Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
13.16Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
13.16Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
13.16Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
13.16Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
13.16Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
12.90Single3EMLZM-2413853EML-A2A-ZM-241385
12.90Single3NY8ICI118-5513NY8-β2-ICI118-551
12.90Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
12.90Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
12.90Single4DAJTiotropium4DAJ-M3-Tiotropium
12.90Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
12.90Single4GBRS-Carazolol4GBR-β2-S-Carazolol
12.90Single4QIMANTA XV4QIM-SMO-ANTA XV
12.90Single5IU8Q274563475IU8-A2A-Q27456347-Na
12.90Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
12.90Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
12.90Single5UENDU1725UEN-A1-DU172
12.90Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
12.90Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
12.90Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
12.90Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
12.90Single6FFHFenobam6FFH-mGlu5-Fenobam
12.90Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
12.90Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
12.90Single6S0LZM-2413856S0L-A2A-ZM-241385
12.90Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.90Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
12.90Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
12.90Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
12.90Single7PYRPSB-21157PYR-A2A-PSB-2115
12.90Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
12.90Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
12.90Single7YXAONO-54306087YXA-S1P5-ONO-5430608
12.90Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
12.90Single8CU6LJ-45178CU6-A2A-LJ-4517
12.90Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
12.90Single8JJOAlprenolol8JJO-β2-Alprenolol
12.90Single8K5DGSK2560738K5D-HCA2-GSK256073
12.90Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
12.90Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
12.90Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
12.90Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
12.90Single8YN8Proxyfan8YN8-H3-Proxyfan-Go/β1/γ2
12.90Single9AS1DMT9AS1-5-HT2A-DMT
12.90Single9CHXS-Carazolol9CHX-β2-S-Carazolol
12.90Single9H37A1IR09H37-A2A-A1IR0-Na
12.90Single9IZCMK19039IZC-HCA2-MK1903-Gi1/β1/γ2
12.90Single9JEAAtropine9JEA-M1-Atropine
12.90Single9KFJPubChem 1383196749KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
12.90Consensusa3_onOrthosteric Liganda3a_on
12.90Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
12.90Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
12.90Consensusdopamine_offOrthosteric Ligandd2_off d3_off
12.90Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
12.90Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
12.90Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
12.90Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
12.90Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
12.90Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
12.90Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
12.82Single6JODAngiotensin II6JOD-AT2-Angiotensin II
12.82Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
12.82Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
12.82Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
12.82Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
12.82Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
12.82Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
12.82Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
12.82Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
12.82Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
12.82Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
12.82Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
12.82Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
12.82Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
12.82Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
12.82Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
12.82Consensusvasop-oxy_onOrthosteric Ligandv2_on
12.82Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
12.50Single2RH1S-Carazolol2RH1-β2-S-Carazolol
12.50Single2YCWS-Carazolol2YCW-β1-S-Carazolol
12.50Single5CGCHTL142425CGC-mGlu5-HTL14242
12.50Single5D6LS-Carazolol5D6L-β2-S-Carazolol
12.50Single5IUAQ274563485IUA-A2A-Q27456348-Na
12.50Single5JQHS-Carazolol5JQH-β2-S-Carazolol
12.50Single5N2RPSB-365N2R-A2A-PSB-36-Na
12.50Single5N2SPSB365N2S-A1-PSB36
12.50Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
12.50Single5X7DS-Carazolol5X7D-β2-S-Carazolol-Cmpd-15
12.50Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
12.50Single6LUQHaloperidol6LUQ-D2-Haloperidol
12.50Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
12.50Single6S0QZM-2413856S0Q-A2A-ZM-241385
12.50Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
12.50Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
12.50Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
12.50Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
12.50Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
12.50Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
12.50Single7W41PD1762527W41-BB2-PD176252
12.50Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
12.50Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
12.50Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
12.50Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
12.50Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
12.50Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
12.50Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
12.50Single8GNEKW-63568GNE-A2A-KW-6356-Na
12.50Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
12.50Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
12.50Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
12.50Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
12.50Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
12.50Single8TF5Oleic acid8TF5-GPR6-Oleic acid
12.50Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
12.50Single8XYKVUF106618XYK-CXCR3-VUF10661-Go/β1/γ2
12.50Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
12.50Single8ZMFA1L108ZMF-5-HT2C-A1L10
12.50Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single8ZVZBW245C8ZVZ-DP1-BW245C-Gs/β1/γ2
12.50Single8ZYTNeurotensin peptide 8-138ZYT-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
12.50Single9DYDAsenapine9DYD-5-HT1A-Asenapine-Go/β1/γ2
12.50Single9DYFAsenapine9DYF-5-HT1A-Asenapine-Gi1/β1/γ2
12.50Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
12.50Single9EHSLUF76029EHS-A3A-LUF7602
12.50Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
12.50Single9KPFSA09KPF-TAS2R16-SA0-Gi1/β1/γ2
12.50Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
12.50Consensusa3_on_gpOrthosteric Liganda3a_on_gp
12.50Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
12.50Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
12.50Consensusadenosine_offOrthosteric Liganda1_off a2_off
12.50Consensusadgrg2_onOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
12.50Consensusadgrg2_on_gpOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
12.50Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
12.50Consensusamine_offonOrthosteric Ligandamine_off amine_on
12.50Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
12.50Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
12.50Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
12.50Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
12.50Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
12.50Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
12.50Consensusblt_offOrthosteric Ligandblt1_off
12.50Consensusbombesin_offOrthosteric Ligandbb2_off
12.50Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
12.50Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
12.50Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
12.50Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
12.50Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
12.50Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
12.50Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
12.20Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
12.20Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
12.20Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
12.20Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
12.20Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
12.20Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
12.20Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
12.20Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
12.12Single4U15Tiotropium4U15-M3-Tiotropium
12.12Single5D5AS-Carazolol5D5A-β2-S-Carazolol
12.12Single5D5BS-Carazolol5D5B-β2-S-Carazolol
12.12Single5XRAAM115425XRA-CB1-AM11542
12.12Single6J21Aprepitant6J21-NK1-Aprepitant
12.12Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
12.12Single6OL9Tiotropium6OL9-M5-Tiotropium
12.12Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
12.12Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
12.12Single7F1TMIP-1a7F1T-CCR5-MIP-1a
12.12Single7FEECP559407FEE-CB1-CP55940-ZCZ011
12.12Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
12.12Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
12.12Single7TUYGSK682753A7TUY-GPR183-GSK682753A
12.12Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
12.12Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
12.12Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
12.12Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
12.12Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
12.12Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
12.12Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
12.12Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
12.12Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
12.12Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
12.12Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
12.12Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
12.12Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
12.12Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
12.12Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
12.12Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
12.12Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
12.12Single9AS9RS130-1809AS9-5-HT2A-RS130-180
12.12Single9ASARS130-1809ASA-5-HT2A-RS130-180-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
12.12Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
12.12Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
12.12Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
12.12Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
12.12Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
12.12Consensuslpa_onOrthosteric Ligandlpa1_on
12.12Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
12.12Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
12.12Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
12.12Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
12.12Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
12.12Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
11.90Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
11.90Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
11.90Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
11.76Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
11.76Single3D4STimolol3D4S-β2-Timolol
11.76Single4AMIBucindolol4AMI-β1-Bucindolol
11.76Single4XEENeurotensin4XEE-NTS1-Neurotensin
11.76Single4XESNeurotensin4XES-NTS1-Neurotensin
11.76Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
11.76Single6A93Risperidone6A93-5-HT2A-Risperidone
11.76Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
11.76Single6CM4Risperidone6CM4-D2-Risperidone
11.76Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
11.76Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
11.76Single6KQICP559406KQI-CB1-CP55940-Org27569
11.76Single6YVRNTS8-136YVR-NTS1-NTS8-13
11.76Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
11.76Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
11.76Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
11.76Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
11.76Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
11.76Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
11.76Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
11.76Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
11.76Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
11.76Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
11.76Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
11.76Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
11.76Single8JWZAB9288JWZ-A2A-AB928-Na
11.76Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
11.76Single8XYIVUF106618XYI-CXCR3-VUF10661
11.76Single9AU0BW245C9AU0-DP1-BW245C-Gs/β1/γ2
11.76Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
11.76Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
11.76Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
11.76Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
11.76Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
11.76Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
11.76Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
11.76Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
11.76Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
11.76Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
11.76Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
11.76Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
11.76Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
11.76Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
11.76Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
11.76Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
11.63Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
11.63Consensusendothelin_onOrthosteric Ligandetb_on eta_on
11.54Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
11.54Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
11.54Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
11.54Single8HS2Fab0468HS2-GPR20-Fab046
11.54Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
11.54Single8PWNTheophylline8PWN-A2A-Theophylline
11.54Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
11.43Single4BUONeurotensin4BUO-NTS1-Neurotensin
11.43Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
11.43Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
11.43Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
11.43Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
11.43Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
11.43Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
11.43Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
11.43Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.43Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
11.43Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
11.43Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
11.43Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
11.43Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
11.43Single8S2TIsoprenaline8S2T-β1-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
11.43Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
11.43Single8XVUCXCL28XVU-CXCR2-CXCL2
11.43Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
11.43Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
11.43Single9DYEBuspirone9DYE-5-HT1A-Buspirone-Go/β1/γ2
11.43Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
11.43Single9GG5U466199GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
11.43Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
11.43Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
11.43Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
11.43Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
11.43Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
11.43Consensusprostanoid_offOrthosteric Ligandep_off dp_off
11.11Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
11.11Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
11.11Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
11.11Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
11.11Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
11.11Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
11.11Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
11.11Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
11.11Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
11.11Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
11.11Single8A2OTheophylline8A2O-A2A-Theophylline-Na
11.11Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
11.11Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
11.11Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
11.11Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
11.11Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
11.11Single8X5YAstemizole8X5Y-H1-Astemizole
11.11Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
11.11Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
11.11Single9EE9Adenosine9EE9-A2A-Adenosine-Gs/β1/γ2
11.11Single9IVMLSN33188399IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
11.11Single9M0RNeuropeptide VF9M0R-NPFF1-Neuropeptide VF-Gi1/β1/γ2
11.11Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
11.11Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
11.11Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
11.11Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
11.11Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
11.11Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
11.11Consensussensory_onOrthosteric Ligandopsins_on
10.81Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
10.81Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
10.81Single7F8XNN90567F8X-CCKA-NN9056
10.81Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
10.81Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
10.81Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
10.81Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
10.81Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
10.81Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
10.81Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
10.81Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
10.81Single8PKMBefiradol8PKM-5-HT1A-Befiradol-Gi1/β1/γ1
10.81Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
10.81Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
10.81Single9BUYLM1899BUY-β2-LM189-Gi1/β1/γ2
10.81Single9M4TSilodosin9M4T-Alpha1A-Silodosin
10.81Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
10.81Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
10.81Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
10.81Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
10.81Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
10.81Consensuslpl_onOrthosteric Ligands1p_on lpa_on
10.81Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
10.81Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
10.81Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
10.81Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
10.71Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
10.71Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
10.71Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
10.71Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
10.71Single3UZAGTPL92363UZA-A2A-GTPL9236
10.71Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
10.71Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
10.71Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
10.71Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
10.71Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
10.71Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
10.71Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
10.71Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
10.71Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
10.71Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
10.71Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
10.71Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
10.71Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
10.71Single9LRCHistamine9LRC-H4-Histamine
10.71Single9LREHistamine9LRE-H4-Histamine-Gi1/β1/γ2
10.71Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
10.71Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
10.71Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
10.71Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
10.71Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
10.53Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
10.53Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
10.53Single7XNACYN1548067XNA-SST2-CYN154806
10.53Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
10.53Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
10.53Single9E82SDF-1-beta9E82-ACKR3-SDF-1-β-Arrestin2
10.53Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
10.53Single9KFIRelaxin-39KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
10.53Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
10.53Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
10.53Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
10.53Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
10.53Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
10.34Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
10.34Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
10.34Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
10.34Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
10.34Single3OE9IT1t3OE9-CXCR4-IT1t
10.34Single4O9RCyclopamine4O9R-SMO-Cyclopamine
10.34Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
10.34Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
10.34Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
10.34Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
10.34Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
10.34Single7V68Iperoxo7V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
10.34Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
10.34Single7XP6Strychnine7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
10.34Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
10.34Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
10.34Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
10.34Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
10.34Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
10.34Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
10.34Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
10.34Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
10.34Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
10.34Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
10.34Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
10.34Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
10.34Single8YN7Immethridine8YN7-H3-Immethridine-Go/β1/γ2
10.34Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
10.34Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
10.34Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg4_on
10.34Consensusadgrg_on_gpOrthosteric Ligandadgrg2_on_gp adgrg4_on_gp
10.26Single3OE0CVX153OE0-CXCR4-CVX15
10.26Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
10.26Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
10.26Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
10.26Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
10.26Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
10.26Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
10.26Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
10.26Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
10.26Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
10.26Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
10.26Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
10.26Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
10.26Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
10.26Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
10.20Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
10.20Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
10.00Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
10.00Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
10.00Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
10.00Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
10.00Single3PWHZM-2413853PWH-A2A-ZM-241385
10.00Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
10.00Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
10.00Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
10.00Single4BWBNeurotensin4BWB-NTS1-Neurotensin
10.00Single4QINSAG1.54QIN-SMO-SAG1.5
10.00Single4S0VSuvorexant4S0V-OX2-Suvorexant
10.00Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
10.00Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
10.00Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
10.00Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
10.00Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
10.00Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
10.00Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
10.00Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
10.00Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
10.00Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
10.00Single6TPJSuvorexant6TPJ-OX2-Suvorexant
10.00Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
10.00Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
10.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
10.00Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
10.00Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
10.00Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
10.00Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
10.00Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
10.00Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
10.00Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
10.00Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
10.00Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
10.00Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
10.00Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
10.00Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
10.00Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
10.00Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
10.00Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
10.00Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
10.00Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
10.00Single8GNGIstradefylline8GNG-A2A-Istradefylline
10.00Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
10.00Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
10.00Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
10.00Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
10.00Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
10.00Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
10.00Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
10.00Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
10.00Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
10.00Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
10.00Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
10.00Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
10.00Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
10.00Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
10.00Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
10.00Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
10.00Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
10.00Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
10.00Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
10.00Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
10.00Single8ZBISomatostatin-148ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
10.00Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
10.00Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
10.00Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
10.00Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
10.00Single9K6LSA09K6L-TAS2R16-SA0-Gi2/β1/γ2
10.00Single9KPESA09KPE-TAS2R16-SA0-Gi1/β1/γ2
10.00Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
10.00Consensusalpha2_offOrthosteric Ligandalpha2c_off
10.00Consensusangiotensin_offOrthosteric Ligandat1_off
10.00Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
10.00Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
10.00Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
10.00Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
10.00Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
10.00Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
10.00Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
10.00Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
10.00Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
10.00Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
10.00Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
10.00Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
10.00Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
9.76Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
9.76Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.76Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
9.76Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
9.76Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
9.76Single8ZRTET-18ZRT-ETB-ET-1
9.76Single9JFYhNPSF9JFY-NPFF2-hNPSF-Gi1/β1/γ2
9.76Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
9.68Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
9.68Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
9.68Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
9.68Single5IUBQ274563445IUB-A2A-Q27456344-Na
9.68Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
9.68Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
9.68Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
9.68Single5UVIZM-2413855UVI-A2A-ZM-241385
9.68Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
9.68Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
9.68Single6KUXRS-799486KUX-α2a-RS-79948
9.68Single6PS0S-Carazolol6PS0-β2-S-Carazolol
9.68Single6PS4ICI118-5516PS4-β2-ICI118-551
9.68Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
9.68Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
9.68Single6TP3Nemorexant6TP3-OX1-Nemorexant
9.68Single6V9SGTPL114036V9S-OX1-GTPL11403
9.68Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
9.68Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
9.68Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
9.68Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
9.68Single6ZG9GSK10347026ZG9-M1-GSK1034702
9.68Single7AROLUF58337ARO-A2A-LUF5833-Na
9.68Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
9.68Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
9.68Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
9.68Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
9.68Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
9.68Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.68Single7UTZDPPC7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
9.68Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
9.68Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
9.68Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
9.68Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
9.68Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
9.68Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
9.68Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
9.68Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
9.68Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
9.68Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
9.68Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
9.68Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
9.68Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
9.68Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.68Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.68Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
9.68Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
9.68Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
9.68Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
9.68Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
9.68Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
9.68Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
9.68Single8IHKAcifran8IHK-HCA3-Acifran
9.68Single8JD6VU03647708JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
9.68Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
9.68Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
9.68Single8K2WAMG4878K2W-CXCR3-AMG487
9.68Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
9.68Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
9.68Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
9.68Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.68Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.68Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.68Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.68Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.68Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
9.68Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
9.68Single9AS5Mescaline9AS5-5-HT2A-Mescaline
9.68Single9AS6Mescaline9AS6-5-HT2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
9.68Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
9.68Single9KPDSA09KPD-TAS2R16-SA0-chim(Gs-CtGt3)/β1/γ2
9.68Single9M2FNeuropeptide FF9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
9.68Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
9.68Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
9.68Consensusalpha1_onOrthosteric Ligandalpha1a_on
9.68Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
9.68Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
9.68Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
9.68Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
9.68Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
9.68Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
9.52Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
9.52Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
9.52Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
9.38Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
9.38Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
9.38Single2Y01Dobutamine2Y01-β1-Dobutamine
9.38Single2Y04Salbutamol2Y04-β1-Salbutamol
9.38Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
9.38Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
9.38Single4EJ4Naltrindole4EJ4-δ-Naltrindole
9.38Single4MQSIperoxo4MQS-M2-Iperoxo
9.38Single4QKX35V4QKX-β2-35V
9.38Single4U14Tiotropium4U14-M3-Tiotropium
9.38Single4YAYZD-71554YAY-AT1-ZD-7155
9.38Single5T04Neurotensin5T04-NTS1-Neurotensin
9.38Single6D27CAY104716D27-DP2-CAY10471
9.38Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
9.38Single6GPSMK08126GPS-CCR2-MK0812
9.38Single6H7MSalbutamol6H7M-β1-Salbutamol
9.38Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
9.38Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
9.38Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
9.38Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
9.38Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
9.38Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
9.38Single6PS1Timolol6PS1-β2-Timolol
9.38Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
9.38Single6TOTLemborexant6TOT-OX1-Lemborexant
9.38Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
9.38Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
9.38Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
9.38Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
9.38Single7BU7BI1671077BU7-β1-BI167107
9.38Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
9.38Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
9.38Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
9.38Single7F83PF-051904577F83-Ghrelin-PF-05190457
9.38Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
9.38Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
9.38Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
9.38Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
9.38Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
9.38Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
9.38Single7UL4Alvimopan7UL4-μ-Alvimopan
9.38Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
9.38Single7V3ZCP559407V3Z-CB1-CP55940
9.38Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
9.38Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
9.38Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
9.38Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
9.38Single7WC7Lisuride7WC7-5-HT2A-Lisuride
9.38Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
9.38Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
9.38Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
9.38Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
9.38Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
9.38Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
9.38Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
9.38Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
9.38Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.38Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.38Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.38Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.38Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.38Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.38Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.38Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.38Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.38Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.38Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
9.38Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
9.38Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
9.38Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
9.38Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
9.38Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
9.38Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
9.38Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
9.38Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
9.38Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
9.38Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
9.38Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
9.38Single8JXRLSD8JXR-D1-LSD
9.38Single8PJKST1718PJK-5-HT1A-ST171-Gi1/β1/γ1
9.38Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
9.38Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
9.38Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.38Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.38Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.38Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.38Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.38Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.38Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.38Single8X63Mepyramine8X63-H1-Mepyramine
9.38Single8X64Desloratadine8X64-H1-Desloratadine
9.38Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
9.38Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
9.38Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
9.38Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
9.38Single9PLNN-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLN-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine
9.38Single9PLON-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLO-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine-Go/β1/γ2
9.38Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
9.38Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
9.38Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
9.38Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
9.38Consensusalpha2_onOrthosteric Ligandalpha2b_on
9.38Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
9.38Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
9.38Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
9.38Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
9.38Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
9.38Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
9.38Consensusblt_onOrthosteric Ligandblt1_on
9.38Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
9.38Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
9.38Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
9.38Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
9.38Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
9.38Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
9.38Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
9.38Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
9.38Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
9.38Consensushistamine_offOrthosteric Ligandh1_off
9.38Consensusleukotriene_onOrthosteric Ligandblt_on
9.38Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
9.38Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
9.30Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
9.30Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
9.30Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
9.30Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
9.30Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
9.30Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
9.09Single2Y00Dobutamine2Y00-β1-Dobutamine
9.09Single2Y03Isoprenaline2Y03-β1-Isoprenaline
9.09Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
9.09Single5C1MBU725C1M-μ-BU72
9.09Single5T1ABMS-6815T1A-CCR2-BMS-681-PubChem 12093170
9.09Single5TVNLSD5TVN-5-HT2B-LSD
9.09Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
9.09Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
9.09Single6D26Fevipiprant6D26-DP2-Fevipiprant
9.09Single6GPXMK08126GPX-CCR2-MK0812
9.09Single6IGLIRL16206IGL-ETB-IRL1620
9.09Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
9.09Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
9.09Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
9.09Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
9.09Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
9.09Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
9.09Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
9.09Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
9.09Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
9.09Single6TP6Filorexant6TP6-OX1-Filorexant
9.09Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
9.09Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
9.09Single7C4SS1P7C4S-S1P3-S1P
9.09Single7C61Ergotamine7C61-5-HT1B-Ergotamine
9.09Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
9.09Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
9.09Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
9.09Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
9.09Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
9.09Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
9.09Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
9.09Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
9.09Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
9.09Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
9.09Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
9.09Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
9.09Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
9.09Single8IY6Endothelin-18IY6-ETB-Endothelin-1
9.09Single8QOTNanobody-E8QOT-μ-Nanobody-E
9.09Single8S4DCMF-0198S4D-Apelin-CMF-019
9.09Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
9.09Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
9.09Single8WGBVU01550418WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
9.09Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
9.09Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
9.09Single9ARZ2-bromo-LSD9ARZ-5-HT2A-2-bromo-LSD
9.09Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
9.09Single9F33FOB02-04A9F33-D3-FOB02-04A-Go/β1/γ2
9.09Single9F34FOB02-04A9F34-D3-FOB02-04A-Go/β1/γ2
9.09Single9K07DSO-5a9K07-BB3-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
9.09Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
9.09Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
9.09Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
9.09Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
9.09Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
9.09Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
9.09Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
9.09Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
9.09Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
9.09Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
9.09Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
9.09Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
9.09Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
9.09Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
9.09Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
9.09Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
9.09Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
9.09Consensusdp_offOrthosteric Liganddp2_off
9.09Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
9.09Consensusep_offOrthosteric Ligandep4_off
9.09Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
9.09Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
9.09Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
9.09Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
9.09Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
9.09Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
8.89Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
8.89Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
8.89Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
8.89Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
8.82Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
8.82Single4BV0Neurotensin4BV0-NTS1-Neurotensin
8.82Single4DJHJDTic4DJH-κ-JDTic
8.82Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
8.82Single5XR8AM8415XR8-CB1-AM841
8.82Single6H7JIsoprenaline6H7J-β1-Isoprenaline
8.82Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
8.82Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
8.82Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
8.82Single6OS1TRV0266OS1-AT1-TRV026
8.82Single6TQ7SB-3348676TQ7-OX1-SB-334867
8.82Single6WGTLSD6WGT-5-HT2A-LSD
8.82Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
8.82Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
8.82Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
8.82Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
8.82Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
8.82Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
8.82Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
8.82Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
8.82Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
8.82Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
8.82Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.82Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
8.82Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
8.82Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
8.82Single8E0GBU728E0G-μ-BU72
8.82Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
8.82Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
8.82Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
8.82Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
8.82Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
8.82Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
8.82Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
8.82Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
8.82Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
8.82Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
8.82Single8XVLZibotentan8XVL-ETA-Zibotentan
8.82Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
8.82Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
8.82Single9BJKNaloxone9BJK-μ-Naloxone-NAM
8.82Single9EGOYVF9EGO-CB1-YVF-Gi1/β1/γ2
8.82Single9JMCDS-3801b9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
8.82Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
8.82Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
8.82Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
8.82Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
8.82Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
8.82Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
8.82Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
8.82Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
8.82Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
8.82Consensusneurotensin_onOrthosteric Ligandnts1_on
8.82Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
8.82Consensustachykinin_offOrthosteric Ligandnk1_off
8.70Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
8.70Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
8.57Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
8.57Single4LDEBI1671074LDE-β2-BI167107
8.57Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
8.57Single5X33BIIL2605X33-BLT1-BIIL260
8.57Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
8.57Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
8.57Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
8.57Single6ZG4HTL00099366ZG4-M1-HTL0009936
8.57Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
8.57Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
8.57Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
8.57Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
8.57Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
8.57Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
8.57Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
8.57Single7YITNalfurafine7YIT-κ-Nalfurafine
8.57Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
8.57Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
8.57Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
8.57Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
8.57Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
8.57Single8JJ8Formoterol8JJ8-β2-Formoterol
8.57Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
8.57Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.57Single8XQJJN2418XQJ-Apelin-JN241
8.57Single8XWMCXCL68XWM-CXCR2-CXCL6
8.57Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
8.57Single9DGIZ85267113509DGI-CB1-Z8526711350
8.57Single9GL2Befiradol9GL2-5-HT1A-Befiradol-Gs/β1/γ2
8.57Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
8.57Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
8.57Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
8.57Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
8.57Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
8.57Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
8.57Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
8.57Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
8.57Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
8.57Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
8.57Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
8.57Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
8.57Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
8.57Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
8.57Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
8.57Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
8.57Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
8.57Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
8.57Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
8.33Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
8.33Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
8.33Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
8.33Single5X93K-87945X93-ETB-K-8794
8.33Single6H7LDobutamine6H7L-β1-Dobutamine
8.33Single6IBLArformoterol6IBL-β1-Arformoterol
8.33Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
8.33Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
8.33Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
8.33Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
8.33Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single7UM4AS26747237UM4-5-HT5A-AS2674723
8.33Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
8.33Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
8.33Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
8.33Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
8.33Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
8.33Single8JPFNeurotensin8JPF-NTS1-Neurotensin-SBI-553
8.33Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
8.33Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
8.33Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
8.33Single8XVJMacitentan8XVJ-ETA-Macitentan
8.33Single8XWFCXCL38XWF-CXCR2-CXCL3
8.33Single9CGJC6-Quino9CGJ-δ-C6-Quino-Gi1/β1/γ2
8.33Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
8.33Single9M1HProstaglandin E29M1H-EP1-Prostaglandin E2-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Single9M54Neuropeptide VF9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
8.33Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
8.33Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
8.33Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
8.33Consensuscck_onOrthosteric Ligandccka_on cckb_on
8.33Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
8.33Consensuschemerin_onOrthosteric Ligandcml1_on
8.33Consensusendothelin_offOrthosteric Ligandetb_off
8.33Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
8.33Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
8.33Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
8.33Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
8.33Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
8.11Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
8.11Single6KNMJN241-96KNM-Apelin-JN241-9
8.11Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
8.11Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
8.11Single6PT3DPI-2876PT3-δ-DPI-287
8.11Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
8.11Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
8.11Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
8.11Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
8.11Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
8.11Single7XN9L-054,5227XN9-SST2-L-054,522
8.11Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
8.11Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
8.11Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
8.11Single8QJ2pN1628QJ2-MC4-pN162-Gs
8.11Single8XQJJN2418XQJ-Apelin-JN241
8.11Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
8.11Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
8.11Single9CGKC5-Quino9CGK-δ-C5-Quino-Gi1/β1/γ2
8.11Single9IPYJR14a9IPY-C3aB-JR14a
8.11Single9JF4PD1683689JF4-BB1-PD168368
8.11Single9MD1Buspirone9MD1-5-HT1A-Buspirone-Gz/β1/γ2
8.11Single9V2NMacimorelin9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
8.11Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
8.11Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
7.89Single4IARErgotamine4IAR-5-HT1B-Ergotamine
7.89Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
7.89Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
7.89Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
7.89Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
7.89Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
7.89Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
7.89Single8IEBA1LYA8IEB-GPR156-A1LYA
7.89Single8IEIA1LYA8IEI-GPR156-A1LYA
7.89Single8IEIA1LYA8IEI-GPR156-A1LYA
7.89Single8IEPA1LYA8IEP-GPR156-A1LYA
7.89Single8IEPA1LYA8IEP-GPR156-A1LYA
7.89Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
7.89Single8XWNCXCL88XWN-CXCR2-CXCL8
7.89Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
7.89Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
7.89Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
7.89Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
7.89Consensussomatostatin_offOrthosteric Ligandsst2_off
7.69Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
7.69Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
7.69Single5MZPCaffeine5MZP-A2A-Caffeine-Na
7.69Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
7.69Single7SK5CXCL127SK5-ACKR3-CXCL12
7.69Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
7.69Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
7.69Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
7.69Single8IEBA1LYA8IEB-GPR156-A1LYA
7.69Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
7.69Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
7.69Single9IQSMuscarinic toxin 39IQS-M4-Muscarinic toxin 3
7.69Single9IQVMuscarinic toxin 39IQV-Alpha1A-Muscarinic toxin 3
7.69Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
7.69Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
7.69Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
7.50Single6PT2KGCHM076PT2-δ-KGCHM07
7.50Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
7.50Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
7.50Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
7.50Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
7.50Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
7.50Single9M1OMorphine-Modulating Neuropeptide B9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
7.50Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
7.50Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
7.50Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
7.41Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
7.41Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
7.41Single6VCBLSN31604406VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
7.32Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
7.32Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
7.32Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
7.32Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
7.14Single3RFMCaffeine3RFM-A2A-Caffeine
7.14Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
7.14Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
7.14Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
7.14Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
7.14Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
7.14Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
7.14Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
7.14Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
7.14Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
7.14Consensusp2y_offOrthosteric Ligandp2y1_off
6.98Single7SK3CXCL127SK3-ACKR3-CXCL12
6.90Single3OE6IT1t3OE6-CXCR4-IT1t
6.90Single4XNWMRS25004XNW-P2Y1-MRS2500
6.90Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
6.90Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
6.90Single6ME5Agomelatine6ME5-MT1-Agomelatine
6.90Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
6.90Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
6.90Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
6.90Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
6.90Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.90Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.90Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
6.90Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
6.90Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
6.90Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
6.90Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
6.90Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
6.90Single9JHJC18:0 Ceramide9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
6.90Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
6.82Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
6.82Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
6.82Single9KDFRES-701-39KDF-ETB-RES-701-3
6.67Single3PBLEticlopride3PBL-D3-Eticlopride
6.67Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
6.67Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
6.67Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
6.67Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
6.67Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
6.67Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
6.67Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
6.67Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.67Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
6.67Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
6.67Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
6.67Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
6.67Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
6.67Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
6.67Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
6.67Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
6.67Single9AS2DMT9AS2-5-HT2A-DMT-chim(NtGi1-Gs-CtGq)/β1/γ2
6.67Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
6.67Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
6.67Single9LMPNE52-QQ579LMP-GPR4-NE52-QQ57
6.67Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
6.67Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
6.67Consensusgq_nucleotideOrthosteric Ligandgq_p2y
6.67Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
6.67Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
6.52Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
6.45Single3ODUIT1t3ODU-CXCR4-IT1t
6.45Single4K5YCP-3763954K5Y-CRF1-CP-376395
6.45Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
6.45Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
6.45Single5WS3EMPA5WS3-OX2-EMPA
6.45Single5ZKQABT-4915ZKQ-PAF-ABT-491
6.45Single6B73MP11046B73-κ-MP1104
6.45Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
6.45Single6ME2Ramelteon6ME2-MT1-Ramelteon
6.45Single6ME9Ramelteon6ME9-MT2-Ramelteon
6.45Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
6.45Single6TODEMPA6TOD-OX1-EMPA-Na
6.45Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
6.45Single7BR3Elagolix7BR3-GnRH1-Elagolix
6.45Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
6.45Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
6.45Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
6.45Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
6.45Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
6.45Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
6.45Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
6.45Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
6.45Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.45Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.45Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
6.45Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
6.45Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
6.45Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
6.45Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
6.45Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
6.45Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
6.45Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
6.45Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
6.45Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
6.45Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
6.38Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
6.38Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
6.38Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
6.25Single3REYXAC3REY-A2A-XAC
6.25Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
6.25Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
6.25Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
6.25Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
6.25Single4ZJCSB-6740424ZJC-OX1-SB-674042
6.25Single6A94Zotepine6A94-5-HT2A-Zotepine
6.25Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
6.25Single6PS5S-Propranolol6PS5-β2-S-Propranolol
6.25Single6TPGEMPA6TPG-OX2-EMPA
6.25Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
6.25Single6VI4JDTic6VI4-κ-JDTic
6.25Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
6.25Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
6.25Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
6.25Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
6.25Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
6.25Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
6.25Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
6.25Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
6.25Single7F61PF-036547467F61-H3-PF-03654746
6.25Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25Single7T94LY21196207T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
6.25Single7UL3Famotidine7UL3-H2-Famotidine
6.25Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
6.25Single7VODCariprazine7VOD-5-HT2A-Cariprazine
6.25Single7VV6C48/807VV6-MRGPRX2-C48/80
6.25Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
6.25Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
6.25Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
6.25Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
6.25Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
6.25Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
6.25Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
6.25Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
6.25Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
6.25Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
6.25Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
6.25Single8Y6YGLPG09748Y6Y-FFA2-GLPG0974
6.25Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
6.25Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
6.25Single8ZPMAMD0708ZPM-CXCR4-AMD070
6.25Single8ZPNAMD31008ZPN-CXCR4-AMD3100
6.25Single9AS3LSD9AS3-5-HT2A-LSD
6.25Single9AS4LSD9AS4-5-HT2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
6.25Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
6.25Single9JH3CMF-0199JH3-Apelin-CMF-019-Gi1/β1/γ2
6.25Single9JMDAzithromycin9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
6.25Single9LRDHistamine9LRD-H1-Histamine-Gi1/β1/γ2
6.25Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
6.25Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
6.25Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
6.25Consensusgrh_offOrthosteric Ligandgnrh1_off
6.25Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
6.06Single2Y02Carmoterol2Y02-β1-Carmoterol
6.06Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
6.06Single4Z9GCP-3763954Z9G-CRF1-CP-376395
6.06Single5DHHSB-6121115DHH-NOP-SB-612111
6.06Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
6.06Single5UIGCmpd-15UIG-A2A-Cmpd-1
6.06Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
6.06Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
6.06Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
6.06Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
6.06Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
6.06Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
6.06Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
6.06Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
6.06Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
6.06Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
6.06Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
6.06Single8GTIBMK-C2058GTI-CRF1-BMK-C205
6.06Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
6.06Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
6.06Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
6.06Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
6.06Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
6.06Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
6.06Single8ZYYNeurotensin peptide 8-138ZYY-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
6.06Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
6.06Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
6.06Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
6.06Single9IYAONO-97105319IYA-GPR55-ONO-9710531
6.06Single9JGKBalovaptan9JGK-5-HT2B-Balovaptan
6.06Single9PQD(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole9PQD-α2a-(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole
6.06Consensus5ht5_onOrthosteric Ligand5ht5a_on
6.06Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
6.06Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
6.06Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
6.06Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
6.06Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
6.06Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
6.06Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
5.88Single5WIUNemonapride5WIU-D4-Nemonapride
5.88Single5WIVNemonapride5WIV-D4-Nemonapride-Na
5.88Single5WQCEMPA5WQC-OX2-EMPA
5.88Single5XPRBosentan5XPR-ETB-Bosentan
5.88Single6E67BI1671076E67-β2-BI167107-Gs(CT)
5.88Single6HLPNetupitant6HLP-NK1-Netupitant
5.88Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
5.88Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
5.88Single7WC6LSD7WC6-5-HT2A-LSD
5.88Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
5.88Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.88Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
5.88Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
5.88Single8GTGBMK-I1528GTG-CRF1-BMK-I152
5.88Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
5.88Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
5.88Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
5.88Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
5.88Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
5.88Single9ARYSerotonin9ARY-5-HT2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
5.88Single9GE2ML1849GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
5.88Single9HAPTolvaptan9HAP-V2-Tolvaptan
5.88Single9I52A1IZU9I52-D1-A1IZU-Gs/β1/γ2
5.88Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
5.88Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
5.71Single3P0GBI1671073P0G-β2-BI167107
5.71Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
5.71Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
5.71Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
5.71Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
5.71Single6J20Aprepitant6J20-NK1-Aprepitant
5.71Single7B6WCyclazosin7B6W-α1b-Cyclazosin
5.71Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
5.71Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
5.71Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
5.71Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
5.71Single7R0CAVP7R0C-V2-AVP-Arrestin2
5.71Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662
5.71Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
5.71Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.71Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
5.71Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.71Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
5.71Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
5.71Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
5.71Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
5.71Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
5.71Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
5.71Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
5.71Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
5.71Single8ZWFJR14a8ZWF-C3aB-JR14a
5.71Single9I54A1IZV9I54-D1-A1IZV-Gs/β1/γ2
5.71Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
5.71Single9IK9SST analogue9IK9-SST1-SST analogue-Gi1/β1/γ2
5.71Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
5.71Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
5.56Single4RWADIPP-NH24RWA-δ-DIPP-NH2
5.56Single6MXTSalmeterol6MXT-β2-Salmeterol
5.56Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
5.56Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.56Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
5.56Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.56Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
5.56Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
5.56Single8GTMBMK-C2038GTM-CRF1-BMK-C203
5.56Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
5.56Single8JJLOlodaterol8JJL-β2-Olodaterol
5.56Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
5.56Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
5.56Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
5.56Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
5.56Single8XWACXCL18XWA-CXCR2-CXCL1
5.56Single8XWSCXCL58XWS-CXCR2-CXCL5
5.56Single9BJKNAM9BJK-μ-Naloxone-NAM
5.56Single9M4QDoxazosin9M4Q-Alpha1A-Doxazosin
5.56Consensusalpha1_offOrthosteric Ligandalpha1a_off
5.56Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
5.56Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
5.56Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
5.56Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
5.56Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
5.56Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
5.56Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.56Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
5.41Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
5.41Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
5.41Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
5.41Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
5.41Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
5.41Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
5.41Single8T3OTUG-8918T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
5.41Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
5.41Single8ZPLHF511168ZPL-CXCR4-HF51116
5.41Single8ZWGJR14a8ZWG-C3aB-JR14a-Gi1/β1/γ2
5.41Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
5.41Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
5.41Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
5.41Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
5.26Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
5.26Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
5.26Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
5.26Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
5.26Single8Y72Peptide8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
5.26Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
5.26Single9IPVJR14a9IPV-C3aB-JR14a-Gi1/β1/γ2
5.26Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
5.26Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
5.26Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
5.13Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
5.13Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
5.13Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
5.13Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
5.13Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
5.13Single8ZBJSomatostatin-148ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
5.13Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
5.13Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
5.13Single9HB3Mambaquaretin-19HB3-V2-Mambaquaretin-1
5.13Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
5.00Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
5.00Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
5.00Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
5.00Single9IQRMuscarinic toxin 39IQR-α2a-Muscarinic toxin 3
5.00Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
5.00Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
5.00Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
5.00Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
5.00Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
4.88Single6W25SHU91196W25-MC4-SHU9119-Ca
4.88Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
4.88Single8W8YGamma-MSH8W8Y-MC3-γ-MSH-Ca-Gs/β1/γ2
4.88Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
4.88Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
4.76Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
4.76Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
4.65Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
4.65Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
4.55Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
4.55Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
4.55Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
4.44Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
4.44Single8W8XBeta-MSH8W8X-MC3-β-MSH-Ca-Gs/β1/γ2
4.44Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
4.35Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
4.26Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
4.17Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
4.17Single6D35Cholesterol6D35-SMO-Cholesterol
4.17Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
4.17Single6N51Quisqualate6N51-mGlu5; mGlu5-Quisqualate
4.17Single6UO8SKF975416UO8-GABAB1, GABAB2-SKF97541-GS39783
4.17Single6UO9SKF975416UO9-GABAB1, GABAB2-SKF97541
4.17Single6W2XPubChem 53110426W2X-GABAB1, GABAB2-PubChem 5311042
4.17Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
4.17Single6W2YPubChem 53110426W2Y-GABAB1; GABAB1-PubChem 5311042
4.17Single7C7QBaclofen7C7Q-GABAB1, GABAB2-Baclofen-BHFF
4.17Single7C7SCGP546267C7S-GABAB1, GABAB2-CGP54626
4.17Single7CUMCGP546267CUM-GABAB1, GABAB2-CGP54626
4.17Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.17Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.17Single7DD5Ca7DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.17Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
4.17Single7DGEQuisqualate7DGE-mGlu1; mGlu1-Quisqualate
4.17Single7DTTCa7DTT-CaS-Ca-Ca
4.17Single7DTTCa7DTT-CaS-Ca-Ca
4.17Single7DTUTryptophan7DTU-CaS-Tryptophan
4.17Single7DTUTryptophan7DTU-CaS-Tryptophan
4.17Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
4.17Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
4.17Single7DTVCa7DTV-CaS-Ca-Ca; Tryptophan
4.17Single7DTVCa; Tryptophan7DTV-CaS-Ca-Ca; Tryptophan
4.17Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7E6TCa7E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7E6TCa; Ca; Cyclomethyltryptophan; PO47E6T-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
4.17Single7E9GEglumetad7E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
4.17Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
4.17Single7E9HPhosphoserine7E9H-mGlu4; mGlu4-Phosphoserine-Gi3/β1/γ2
4.17Single7EB2Baclofen7EB2-GABAB2; GABAB1-Baclofen-rac-BHFF-Gi1/β1/γ2
4.17Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
4.17Single7EPBEglumetad7EPB-mGlu2; mGlu2-Eglumetad
4.17Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
4.17Single7FD8Quisqualate7FD8-mGlu5; mGlu5-Quisqualate
4.17Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
4.17Single7FD9LY3414957FD9-mGlu5; mGlu5-LY341495
4.17Single7FIHhCG7FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
4.17Single7FIIhCG7FII-LH-hCG-chim(NtGi1-Gs)/β1/γ2
4.17Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
4.17Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
4.17Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.17Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
4.17Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.17Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.17Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.17Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
4.17Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
4.17Single7MTQLY3414957MTQ-mGlu2; mGlu2-LY341495
4.17Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.17Single7MTRGlutamate7MTR-mGlu2; mGlu2-Glutamate-ADX55164
4.17Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
4.17Single7MTSGlutamate7MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
4.17Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.17Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.17Single7SILCa7SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.17Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
4.17Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7SIMCa7SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7SIMCa; Ca; Cyclomethyltryptophan; PO47SIM-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; PO4
4.17Single7T9NM22 Fab7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
4.17Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
4.17Single7WI6LY3414957WI6-mGlu3; mGlu3-LY341495
4.17Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
4.17Single7WI8LY3414957WI8-mGlu3; mGlu3-LY341495
4.17Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
4.17Single7WIHLY27941937WIH-mGlu3; mGlu3-LY2794193
4.17Single7XW6M22 Fab7XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
4.17Single7XW7K1-707XW7-TSH-K1-70
4.17Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
4.17Single8JCULY3414958JCU-mGlu2; mGlu3-LY341495
4.17Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
4.17Single8JCVLY3414958JCV-mGlu2; mGlu3-LY341495
4.17Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
4.17Single8JCWLY3414958JCW-mGlu2; mGlu3-LY341495
4.17Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
4.17Single8JCXLY3414958JCX-mGlu2; mGlu3-LY341495
4.17Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
4.17Single8JCYLY3414958JCY-mGlu2; mGlu3-LY341495
4.17Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
4.17Single8JCZLY3414958JCZ-mGlu2; mGlu3-LY341495
4.17Single8JD0Glutamate8JD0-mGlu2; mGlu3-Glutamate-NAM563
4.17Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
4.17Single8JD1Glutamate8JD1-mGlu2; mGlu3-Glutamate
4.17Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
4.17Single8JD2Glutamate8JD2-mGlu2; mGlu3-Glutamate
4.17Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
4.17Single8JD3Glutamate8JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
4.17Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
4.17Single8JD4Glutamate8JD4-mGlu2; mGlu4-Glutamate
4.17Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
4.17Single8JD5Glutamate8JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
4.17Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
4.17Single8JD6Phosphoserine8JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
4.17Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
4.17Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
4.17Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
4.17Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
4.17Single8T7HQuisqualate8T7H-mGlu5; mGlu5-Quisqualate
4.17Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
4.17Single8T8MQuisqualate8T8M-mGlu5; mGlu5-Quisqualate
4.17Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.17Single8TAOQuisqualate8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
4.17Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
4.17Single8TQBCa; PAM VU60233268TQB-mGlu3; mGlu3-Ca; PAM VU6023326-Ca
4.17Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
4.17Single8TR0LY3414958TR0-mGlu3; mGlu3-LY341495
4.17Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
4.17Single8TR2Ca; LY3792688TR2-mGlu3; mGlu3-Ca; LY379268-Ca
4.17Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
4.17Single8TRCLY3414958TRC-mGlu3; mGlu3-LY341495
4.17Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
4.17Single8TRDLY3414958TRD-mGlu3; mGlu3-LY341495
4.17Single8WG9(2S)-2-amino-4-phosphonobutanoic acid8WG9-mGlu4; mGlu2-(2S)-2-amino-4-phosphonobutanoic acid
4.17Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
4.17Single8WGBGlutammate8WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
4.17Single8WGCLY3792688WGC-mGlu4; mGlu2-LY379268
4.17Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
4.17Single8WGDWAG; WA68WGD-mGlu4; mGlu2-WAG; WA6
4.17Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.17Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
4.17Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.17Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
4.17Single8WVXNorrin8WVX-LGR4-Norrin
4.17Single8WVYNorrin8WVY-LGR4-Norrin
4.17Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.17Single8X0BQuisqualate8X0B-mGlu5; mGlu5-Quisqualate-VU0424465
4.17Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
4.17Single8X0CQuisqualate8X0C-mGlu5; mGlu5-Quisqualate-VU0424465
4.17Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.17Single8X0DQuisqualate8X0D-mGlu5; mGlu5-Quisqualate-VU0424465
4.17Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
4.17Single8X0EQuisqualate8X0E-mGlu5; mGlu5-Quisqualate
4.17Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
4.17Single8X0FQuisqualate8X0F-mGlu5; mGlu5-Quisqualate-VU0424465
4.17Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
4.17Single8X0GQuisqualate8X0G-mGlu5; mGlu5-Quisqualate
4.17Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
4.17Single8X0HQuisqualate8X0H-mGlu5; mGlu5-Quisqualate
4.17Single8XUMR-spondin-28XUM-LGR4-R-spondin-2
4.17Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.17Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.17Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.17Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.17Single9AVLCa9AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.17Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
4.17Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single9AXFCa9AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.17Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.17Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.17Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.17Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.17Single9C1PCa9C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.17Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
4.17Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
4.17Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
4.17Single9C2FCa9C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
4.17Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
4.17Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
4.17Single9II2Glutamate9II2-mGlu3; mGlu3-Glutamate-Arrestin2
4.17Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
4.17Single9II3Glutamate9II3-mGlu3; mGlu3-Glutamate-Arrestin2
4.17Single9KHHNorrin9KHH-LGR4-Norrin
4.17Single9S37NB219S37-LGR4-NB21
4.17Single9UTBSucralose9UTB-TAS1R2; TAS1R3-Sucralose
4.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.00Single7DD6Ca7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.00Single7DD6Ca; Ca; Tryptophan7DD6-CaS-Ca-Ca; Ca; Tryptophan
4.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.00Single7DD7Ca7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
4.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
4.00Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
4.00Single9ASBCa9ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
4.00Single9AVGCa9AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.00Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
4.00Single9AYFCa9AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.00Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
4.00Consensusclass-b2_onOrthosteric Ligandadgrg_on adgrf_on adgrl_on adgre_on adgrd_on
4.00Consensusclass-b2_on_gpOrthosteric Ligandadgrg_on_gp adgrf_on_gp adgrl_on_gp adgre_on_gp adgrd_on_gp
3.85Single7KNUCalcitonin gene-related peptide-17KNU-CT Like-Calcitonin gene-related peptide-1-RAMP1
3.85Single7T9MCS-17 Antibody7T9M-TSH-CS-17 Antibody
3.85Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
3.70Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
3.70Single7FIGhCG7FIG-LH-hCG-chim(NtGi1L-Gs)/β1/γ2
3.70Single7UTZTR14027UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
3.70Single7XW5TSH7XW5-TSH-TSH-ML109-Gs/β1/γ2
3.70Single7ZI0Cholesterol7ZI0-SMO-SAG-Cholesterol
3.70Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
3.70Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
3.57Single5L7DCholesterol5L7D-SMO-Cholesterol
3.57Single7T9ITSH7T9I-TSH-TSH-Gs/β1/γ2
3.57Single7V68LY21196207V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
3.57Single8I2GGlycoprotein hormones alpha chain8I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
3.57Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
3.45Single3OE8IT1t3OE8-CXCR4-IT1t
3.45Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
3.45Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
3.45Single9CHUNoradrenaline9CHU-β2-Noradrenaline
3.33Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
3.33Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.33Single8JPSCCL78JPS-ACKR1-CCL7
3.33Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
3.33Consensus5ht2_onOrthosteric Ligand5ht2b_on
3.33Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.33Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
3.23Single6HLLCP999946HLL-NK1-CP99994
3.23Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
3.23Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
3.23Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
3.23Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.23Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
3.23Single7SRQLSD7SRQ-5-HT2B-LSD
3.23Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
3.23Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
3.23Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
3.23Single8HNNSCH5467388HNN-CXCR3-SCH546738
3.23Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
3.23Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.23Single8ZYUNeurotensin peptide 8-138ZYU-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
3.23Single9AS7Psilocin9AS7-5-HT2A-Psilocin
3.23Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
3.23Single9IXJHistamine9IXJ-H2-Histamine-Gs/β1/γ2
3.23Single9IZDCHBA9IZD-HCA1-CHBA-Gi1/β1/γ2
3.23Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
3.23Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
3.23Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
3.12Single6AKXA4R6AKX-CCR5-A4R
3.12Single6AKYMaraviroc6AKY-CCR5-Maraviroc
3.12Single6C1QNDT95137276C1Q-C5a1-PMX53-NDT9513727
3.12Single6DS0Ly2660976DS0-5-HT2B-Ly266097
3.12Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
3.12Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
3.12Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
3.12Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
3.12Single7F8ULintitript7F8U-CCKA-Lintitript
3.12Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
3.12Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.12Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
3.12Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
3.12Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
3.12Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
3.12Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
3.12Single7XRRLemborexant7XRR-OX2-Lemborexant
3.12Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.12Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
3.12Single8U4PAMD31008U4P-CXCR4-AMD3100-Gi1/β1/γ2
3.12Single9LRBHistamine9LRB-H1-Histamine-Gs/β1/γ2
3.12Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
3.12Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
3.12Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
3.12Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
3.12Consensusorexin_offOrthosteric Ligandox2_off ox1_off
3.12Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
3.03Single3RZECidoxepin3RZE-H1-Cidoxepin
3.03Single4MBSMaraviroc4MBS-CCR5-Maraviroc
3.03Single6IQLL7458706IQL-D4-L745870
3.03Single6TPKRetosiban6TPK-OT-Retosiban
3.03Single6TPNHTL66416TPN-OX2-HTL6641
3.03Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
3.03Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.03Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
3.03Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
3.03Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
3.03Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
3.03Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
3.03Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
3.03Single9ARXSerotonin9ARX-5-HT2A-Serotonin
3.03Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
3.03Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
3.03Consensusvasop-oxy_offOrthosteric Ligandot_off
2.94Single5DHGC-355DHG-NOP-C-35
2.94Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
2.94Single6DRXLisuride6DRX-5-HT2B-Lisuride
2.94Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
2.94Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
2.94Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
2.94Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
2.94Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
2.94Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
2.94Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.94Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
2.94Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
2.94Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
2.94Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
2.94Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
2.94Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
2.86Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
2.86Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
2.86Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
2.86Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
2.86Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
2.86Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
2.86Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
2.86Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.86Single8JXSPF-61428JXS-D1-PF-6142
2.86Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
2.86Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
2.86Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
2.78Single5TZRMK86665TZR-FFA1-MK8666
2.78Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
2.78Single6E59L-7607356E59-NK1-L-760735
2.78Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
2.78Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
2.78Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
2.78Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
2.78Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
2.78Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
2.78Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
2.78Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
2.78Single8Y73Peptide8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
2.78Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
2.78Single9UY3Anamorelin9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
2.78Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
2.78Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
2.78Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
2.78Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
2.78Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
2.78Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
2.70Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
2.70Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
2.70Single4PY02MeSATP4PY0-P2Y12-2MeSATP
2.70Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
2.70Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
2.70Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
2.70Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
2.70Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
2.70Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
2.70Consensusorexin_onOrthosteric Ligandox2_on
2.63Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
2.63Single6K1QIRL25006K1Q-ETB-IRL2500
2.63Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
2.63Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
2.63Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
2.63Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
2.63Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
2.56Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
2.56Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
2.56Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
2.56Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
2.56Consensuskisspeptin_onOrthosteric Ligandkiss1_on
2.50Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
2.50Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
2.50Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
2.50Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
2.50Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
2.50Single8KIGSHU91198KIG-MC3-SHU9119-Ca
2.50Single8WKYPG-9348WKY-MC4-PG-934
2.50Single8XFTR-spondin-28XFT-LGR4-R-spondin-2-ZNRF3
2.50Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
2.50Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
2.50Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
2.50Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
2.50Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
2.50Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
2.50Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
2.50Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
2.44Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
2.44Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
2.44Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
2.44Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
2.44Single9IK8SST analogue9IK8-SST1-SST analogue-Gi1/β1/γ2
2.44Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
2.44Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
2.38Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
2.38Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
2.38Single8WVUR-spondin-18WVU-LGR4-R-spondin-1-RNF43
2.38Single8Y69R-spondin-28Y69-LGR4-R-spondin-2-ZNRF3
2.38Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
2.38Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
2.38Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
2.38Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
2.33Single8XFPR-spondin-28XFP-LGR4-R-spondin-2-ZNRF3
2.33Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
2.27Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
2.17Single8W8WAlpha-MSH8W8W-MC3-α-MSH-Ca-Gs/β1/γ2
2.17Single8XFSR-spondin-28XFS-LGR4-R-spondin-2-ZNRF3

PDB Summary
PDB 9BTW
Class B1
SubFamily Peptide
Type Calcitonin
SubType CT (AMY3)
Species Homo Sapiens
Ligand Cagrilintide
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2; RAMP3
PDB Resolution 3
Date 2025-04-16
D.O.I. To be published
Net Summary
Imin 1.64
Number of Linked Nodes 1100
Number of Links 1593
Number of Hubs 325
Number of Links mediated by Hubs 1127
Number of Communities 26
Number of Nodes involved in Communities 483
Number of Links involved in Communities 815
Path Summary
Number Of Nodes in MetaPath 281
Number Of Links MetaPath 280
Number of Shortest Paths 131205809
Length Of Smallest Path 3
Average Path Length 64
Length of Longest Path 60
Minimum Path Strength 1.26
Average Path Strength 8.0121
Maximum Path Strength 20.61
Minimum Path Correlation 0.7
Average Path Correlation 1
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.63158
Average % Of Corr. Nodes 81.3939
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 128
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • G protein-coupled receptor-like
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeNAG
PDB ResiduesH:H:?501 H:H:?502
Environment DetailsOpen EMBL-EBI Page
CodeNAG
NameN-Acetylglucosamine
SynonymsN-Acetylglucosamine
Identifier
FormulaC8 H15 N O6
Molecular Weight221.208
SMILES
PubChem24139
Formal Charge0
Total Atoms30
Total Chiral Atoms5
Total Bonds30
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>9BTW_Chain_A
DQRNEEKAQ REANKKIEK QLQKDKQVY RATHRLLLL GAGESGKTI 
VKQMTSGIF ETKFQVDKV NFHMFDVGQ RDERRKWIQ CFNDVTAII 
FVVASSSYN NRLQALLFS IWNNWLRSV ILFLNKQDL LAEKVLAGK 
SKIEDYFPE FARYTTPED ATPEPGEDP RVTRAKYFI RDEFLRIST 
ASGDGRHYC YPHFTCVDT ENIRRVFND CRDIIQRMH LRQYELLNA 
AKDKDTS


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ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>9BTW_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainE
ProteinRAMP3
UniProtO60896
Sequence
>9BTW_Chain_E
ETGMLERLP LCGKAFADM MGKVDVWKW CNLSEFIVY YESFTNCTE 
MEANVVGCY WPNPLAQGF ITGIHRQFF SNCTVDRVH LEDPPDEVL 
IPLIVIPVV LTVAMAGLV VWRSKR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>9BTW_Chain_G
SIAQARKLV EQLKMEANI DRIKVSKAA ADLMAYCEA HAKEDPLLT 
PVPASENPF R


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ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP30988
Sequence
>9BTW_Chain_R
YVVGRKKMM DAQYKCYDR MQQLPAYQG EGPYCNRTW DGWLCWDDT 
PAGVLSYQF CPDYFPDFD PSEKVTKYC DEKGVWFKH PENNRTWSN 
YTMCNAFTP EKLKNAYVL YYLAIVGHS LSIFTLVIS LGIFVFFRS 
LGCQRVTLH KNMFLTYIL NSMIIIIHL VEVVPNGEL VRRDPVSCK 
ILHFFHQYM MACNYFWML CEGIYLHTL IVVAVFTEK QRLRWYYLL 
GWGFPLVPT TIHAITRAV YFNDNCWLS VETHLLYII HGPVMAALV 
VNFFFLLNI VRVLVTKMR ETHEAESHM YLKAVKATM ILVPLLGIQ 
FVVFPWRPS NKMLGKIYD YVMHSLIHF QGFFVATIY CFCNNEVQT 
TVKRQWAQF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8F0KB1PeptideCalcitoninCT (AMY3)Homo sapiensPramlintide Analogue San385-Gs/β1/γ2; RAMP31.92023-08-02doi.org/10.1038/s41589-023-01393-4
8F0K (No Gprot) B1PeptideCalcitoninCT (AMY3)Homo sapiensPramlintide Analogue San385-1.92023-08-02doi.org/10.1038/s41589-023-01393-4
8F2AB1PeptideCalcitoninCT (AMY3)Homo sapiensPramlintide Analogue San385-Gs/β1/γ2; RAMP32.22023-08-02doi.org/10.1038/s41589-023-01393-4
8F2A (No Gprot) B1PeptideCalcitoninCT (AMY3)Homo sapiensPramlintide Analogue San385-2.22023-08-02doi.org/10.1038/s41589-023-01393-4
8F2BB1PeptideCalcitoninCT (AMY3)Homo sapiensPramlintide Analogue San45-Gs/β1/γ2; RAMP322023-08-02doi.org/10.1038/s41589-023-01393-4
8F2B (No Gprot) B1PeptideCalcitoninCT (AMY3)Homo sapiensPramlintide Analogue San45-22023-08-02doi.org/10.1038/s41589-023-01393-4
7TZFB1PeptideCalcitoninCT (AMY3)Homo sapiensAmylin-Gs/β1/γ2; RAMP32.42022-03-23doi.org/10.1126/science.abm9609
7TZF (No Gprot) B1PeptideCalcitoninCT (AMY3)Homo sapiensAmylin-2.42022-03-23doi.org/10.1126/science.abm9609
9BTW (No Gprot) B1PeptideCalcitoninCT (AMY3)Homo sapiensCagrilintide-32025-04-16To be published




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