Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:I19 2.835469
2A:A:V34 3.5465195
3A:A:F191 6.045405
4A:A:F199 6.0725415
5A:A:V201 3.8125409
6A:A:R208 3.572519
7A:A:K210 4.418519
8A:A:W211 4.1975819
9A:A:F215 3.885619
10A:A:F223 5.79509
11A:A:Y230 8.33333678
12A:A:D231 8.805409
13A:A:L249 2.93419
14A:A:F250 5.002509
15A:A:I253 3.65518
16A:A:C254 3.214215
17A:A:N255 5.1525408
18A:A:W258 6.3845125
19A:A:F259 3.446519
20A:A:I265 2.78438
21A:A:F267 4.178539
22A:A:L268 5.075478
23A:A:N269 6.0125409
24A:A:F274 6.02579
25A:A:C286 4.7825406
26A:A:Y287 5.421676167
27A:A:Y290 8.7025407
28A:A:Y302 9.71754166
29A:A:N311 3.254218
30A:A:Y320 4.83167637
31A:A:H322 7.65439
32A:A:F323 2.76474
33A:A:K330 4.9375434
34A:A:N331 5.8275408
35A:A:Q333 5.265435
36A:A:F336 4.7375408
37A:A:D341 6.13438
38A:A:I344 3.9475436
39A:A:L348 4.738539
40B:B:L14 4.31508
41B:B:L30 4.33405
42B:B:T34 3.302585
43B:B:M45 3.78404
44B:B:R48 2.8425497
45B:B:R49 3.525497
46B:B:H54 8.626569
47B:B:Y59 6.75128
48B:B:W63 4.63833607
49B:B:V71 3.2045118
50B:B:D76 6.03469
51B:B:L79 3.34117
52B:B:I81 3.084117
53B:B:W82 7.93167669
54B:B:K89 4.92769
55B:B:H91 4.265405
56B:B:I93 3.675407
57B:B:L95 3.114118
58B:B:W99 5.7675419
59B:B:Y105 2.9656116
60B:B:N110 6.1454174
61B:B:Y111 5.14754174
62B:B:C114 3.3554118
63B:B:L117 3.59419
64B:B:Y124 4.478506
65B:B:T128 3.6745243
66B:B:L139 6.23409
67B:B:H142 6.13333619
68B:B:Y145 3.66889918
69B:B:F151 4.64509
70B:B:S161 7.0875419
71B:B:D163 6.0425419
72B:B:W169 8.838518
73B:B:T178 3.385444
74B:B:F180 6.754547
75B:B:H183 6.87286749
76B:B:L190 4.045405
77B:B:L192 2.6225445
78B:B:F199 5.6275449
79B:B:S201 3.81549
80B:B:D205 6.07449
81B:B:K209 7.864546
82B:B:L210 3.6675405
83B:B:W211 7.5648
84B:B:R219 4.854265
85B:B:F222 5.61558
86B:B:H225 8.558559
87B:B:D228 6.5875419
88B:B:I232 4.775458
89B:B:F235 4.351676276
90B:B:N237 3.555405
91B:B:F241 5.14333656
92B:B:T243 4.51458
93B:B:D247 6.5475459
94B:B:T249 3.6775456
95B:B:R251 7.80833658
96B:B:F253 5.782556
97B:B:D258 7.915457
98B:B:Q259 3.4925406
99B:B:M262 4.135404
100B:B:Y264 3.70333605
101B:B:R283 6.6589
102B:B:L284 3.706585
103B:B:Y289 7.9954187
104B:B:W297 5.22754188
105B:B:L300 4.3675486
106B:B:R304 5.9554185
107B:B:H311 9.24254149
108B:B:R314 13.95754128
109B:B:T321 5.0154237
110B:B:W332 10.63717129
111B:B:D333 5.305409
112B:B:K337 6.84254146
113B:B:W339 6.501676149
114G:G:D48 5.238509
115G:G:P49 3.855407
116G:G:L51 3.025486
117G:G:N59 3.675499
118G:G:F61 4.07143798
119L:L:?1 7.261581920
120R:R:M109 7.25403
121R:R:T130 5.7285107
122R:R:N134 6.5145109
123R:R:R148 4.9054138
124R:R:Y153 5.7756139
125R:R:F155 5.424308
126R:R:L159 4.255409
127R:R:D163 11.0354109
128R:R:F170 2.998527
129R:R:S173 4.7225424
130R:R:F177 2.77524
131R:R:T197 4.77426
132R:R:F200 6.936527
133R:R:R214 5.064509
134R:R:I218 4.035409
135R:R:Y224 6.40667607
136R:R:F237 4.8445308
137R:R:I267 9.0375424
138R:R:F268 8.174525
139R:R:Y275 6.14286727
140R:R:W279 4.75333626
141R:R:Y294 4.638336159
142R:R:H304 5.8875437
143R:R:R311 4.105435
144R:R:D338 4.2445337
145R:R:L341 2.7075438
146R:R:I348 3.9354158
147R:R:W356 8.54528
148R:R:M363 3426
149R:R:L387 3.75527
150R:R:N389 6.3425429
151R:R:I396 4.1745159
152R:R:Y397 3.915159
153R:R:D403 2.7454136
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:I344 A:A:L348 45.58722.85YesYes369
2A:A:I344 R:R:H304 45.92846.63YesYes367
3A:A:D341 R:R:H304 91.74663.78YesYes387
4A:A:D341 A:A:Y320 92.17316.9YesYes387
5A:A:F334 A:A:Y320 91.92262.06NoYes337
6A:A:F334 A:A:H322 90.254415.84NoYes339
7A:A:H322 A:A:N331 91.92512.55YesYes098
8A:A:N331 A:A:Q52 95.332111.88YesNo089
9A:A:M53 A:A:Q52 95.59012.72NoNo089
10A:A:M198 A:A:M53 95.17814.33NoNo2078
11A:A:L38 A:A:M198 99.25364.24NoNo087
12A:A:K46 A:A:L38 99.37874.23NoNo098
13A:A:G202 A:A:K46 99.75181.74NoNo099
14A:A:G202 A:A:V201 1001.84NoYes099
15A:A:V201 A:A:W211 82.96487.36YesYes099
16A:A:W211 B:B:L117 43.59972.28YesYes199
17B:B:L117 B:B:M101 34.38692.83YesNo199
18B:B:G116 B:B:M101 67.20583.49NoNo099
19B:B:G115 B:B:G116 67.08892.11NoNo099
20B:B:C114 B:B:G115 66.42621.96YesNo089
21B:B:C114 B:B:L79 64.48633.17YesYes1187
22B:B:L79 B:B:V71 59.46312.98YesYes1178
23A:A:L348 R:R:M337 45.55982.83YesNo396
24R:R:H304 R:R:M337 45.73046.57YesNo376
25A:A:W211 B:B:Y145 36.54751.93YesYes198
26B:B:M101 B:B:Y145 32.9443.59NoYes198
27B:B:V71 B:B:Y105 54.57455.05YesYes1186
28B:B:L69 B:B:Y105 10.37652.34NoYes056
29B:B:D66 B:B:L69 10.18274.07NoNo085
30B:B:Q75 B:B:W99 39.08465.48NoYes099
31B:B:Q75 B:B:Y59 38.850615.78NoYes098
32B:B:W332 B:B:Y59 37.09455.79YesYes1298
33B:B:R314 B:B:W332 23.963526.99YesYes1289
34B:B:L117 B:B:W99 14.9984.56YesYes199
35A:A:L37 A:A:V201 17.80422.98NoYes099
36A:A:F215 A:A:L37 14.69387.31YesNo099
37A:A:F215 A:A:W211 13.50843.01YesYes199
38A:A:F215 B:B:W99 25.38585.01YesYes199
39A:A:L353 R:R:R214 79.94733.64NoYes079
40A:A:L353 R:R:L341 79.9652.77NoYes378
41A:A:L348 R:R:L341 80.47272.77YesYes398
42R:R:I156 R:R:Y153 10.53474.84NoYes089
43R:R:I156 R:R:Y397 20.92082.42NoYes089
44R:R:R214 R:R:Y397 70.29015.14YesYes099
45B:B:H62 B:B:Y105 63.46812.18NoYes066
46B:B:H62 B:B:R150 63.30319.03NoNo066
47B:B:L190 B:B:R150 29.95632.43YesNo056
48B:B:L190 B:B:S160 29.40286.01YesNo056
49B:B:S160 B:B:V187 29.03764.85NoNo069
50B:B:S201 B:B:V187 27.62733.23YesNo499
51B:B:G202 B:B:S201 55.36271.86NoYes069
52B:B:G202 B:B:I229 54.96861.76NoNo067
53B:B:H225 B:B:I229 54.57422.65YesNo097
54B:B:H225 B:B:T243 35.33445.48YesYes598
55B:B:F241 B:B:T243 18.49162.59YesYes568
56B:B:F222 B:B:F241 13.99978.57YesYes586
57B:B:D258 B:B:F222 39.51363.58YesYes578
58B:B:D258 B:B:R22 35.85068.34YesNo076
59B:B:I18 B:B:R22 24.74596.26NoNo076
60B:B:I18 G:G:A23 23.51093.25NoNo078
61B:B:Q17 G:G:A23 22.27564.55NoNo048
62B:B:L14 B:B:Q17 21.04012.66YesNo084
63B:B:E10 B:B:L14 13.6227.95NoYes088
64B:B:E10 G:G:V16 12.38487.13NoNo087
65B:B:L192 B:B:R150 33.19662.43YesNo056
66B:B:F199 B:B:L192 32.27682.44YesYes495
67B:B:F199 B:B:W211 30.687511.02YesYes498
68B:B:S201 B:B:W211 27.86844.94YesYes498
69B:B:F253 B:B:T243 14.38723.89YesYes568
70B:B:F222 B:B:F253 27.98956.43YesYes586
71B:B:H225 B:B:R251 16.845716.93YesYes598
72B:B:F253 B:B:R251 14.43053.21YesYes568
73B:B:I43 B:B:M45 10.42542.92NoYes034
74B:B:I43 B:B:L284 10.15632.85NoYes035
75B:B:D290 B:B:R314 16.335320.25NoYes068
76B:B:C271 B:B:D290 16.03033.11NoNo056
77B:B:C271 B:B:D291 15.42356.22NoNo058
78B:B:D291 B:B:N293 15.12336.73NoNo085
79B:B:N293 B:B:V307 14.52462.96NoNo053
80B:B:R304 B:B:V307 14.2282.62YesNo053
81B:B:R304 B:B:W297 11.62329YesYes1858
82B:B:W297 B:B:Y264 11.10113.86YesYes085
83R:R:I396 R:R:Y397 42.36324.84YesYes1599
84R:R:I396 R:R:N393 39.37452.83YesNo099
85R:R:N389 R:R:N393 39.14796.81YesNo099
86L:L:?1 R:R:N389 34.63654.15YesYes209
87R:R:G157 R:R:I156 10.11611.76NoNo068
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:F170 2.21 2 Yes Yes 0 7 0 1
L:L:?1 R:R:S173 3.63 2 Yes Yes 0 4 0 1
L:L:?1 R:R:F177 2.21 2 Yes Yes 0 4 0 1
L:L:?1 R:R:K192 11.93 2 Yes No 0 6 0 1
L:L:?1 R:R:L193 7.52 2 Yes No 0 4 0 1
L:L:?1 R:R:V196 8.1 2 Yes No 0 7 0 1
L:L:?1 R:R:T197 6.23 2 Yes Yes 0 6 0 1
L:L:?1 R:R:F200 19.86 2 Yes Yes 0 7 0 1
L:L:?1 R:R:F268 16.19 2 Yes Yes 0 5 0 1
L:L:?1 R:R:Y275 5.67 2 Yes Yes 0 7 0 1
L:L:?1 R:R:L276 3.34 2 Yes No 0 5 0 1
L:L:?1 R:R:W279 9.63 2 Yes Yes 0 6 0 1
L:L:?1 R:R:W356 15.82 2 Yes Yes 0 8 0 1
L:L:?1 R:R:L359 5.85 2 Yes No 0 7 0 1
L:L:?1 R:R:M363 2.56 2 Yes Yes 0 6 0 1
L:L:?1 R:R:S383 1.81 2 Yes No 0 6 0 1
L:L:?1 R:R:C386 9.59 2 Yes No 0 7 0 1
L:L:?1 R:R:N389 4.15 2 Yes Yes 0 9 0 1
R:R:F177 R:R:M109 2.49 2 Yes Yes 4 3 1 2
R:R:F170 R:R:F174 2.14 2 Yes No 7 5 1 2
R:R:F170 R:R:F200 3.22 2 Yes Yes 7 7 1 1
R:R:F170 R:R:M384 4.98 2 Yes No 7 5 1 2
R:R:F170 R:R:L387 2.44 2 Yes Yes 7 7 1 2
R:R:K192 R:R:S173 12.24 2 No Yes 6 4 1 1
R:R:F174 R:R:H178 14.71 0 No No 5 4 2 2
R:R:F177 R:R:H178 4.53 2 Yes No 4 4 1 2
R:R:F177 R:R:F189 2.14 2 Yes No 4 9 1 2
R:R:F177 R:R:K192 2.48 2 Yes No 4 6 1 1
R:R:G194 R:R:T197 1.82 0 No Yes 6 6 2 1
R:R:F200 R:R:V196 2.62 2 Yes No 7 7 1 1
R:R:T197 R:R:Y275 3.75 2 Yes Yes 6 7 1 1
R:R:T197 R:R:W279 7.28 2 Yes Yes 6 6 1 1
R:R:F200 R:R:W279 2 2 Yes Yes 7 6 1 1
R:R:C386 R:R:F200 6.98 2 No Yes 7 7 1 1
R:R:T201 R:R:W279 2.43 0 No Yes 6 6 2 1
R:R:V204 R:R:W356 4.9 0 No Yes 7 8 2 1
R:R:I247 R:R:Y275 3.63 0 No Yes 5 7 2 1
R:R:L250 R:R:P251 9.85 2 No No 5 6 2 2
R:R:L250 R:R:Y275 9.38 2 No Yes 5 7 2 1
R:R:P251 R:R:Y275 11.13 2 No Yes 6 7 2 1
R:R:F268 R:R:I267 16.33 2 Yes Yes 5 4 1 2
R:R:F379 R:R:I267 11.3 2 No Yes 4 4 2 2
R:R:F268 R:R:I271 3.77 2 Yes No 5 3 1 2
R:R:F268 R:R:L276 2.44 2 Yes No 5 5 1 1
R:R:F268 R:R:F379 2.14 2 Yes No 5 4 1 2
R:R:I271 R:R:Y275 4.84 0 No Yes 3 7 2 1
R:R:D272 R:R:Y275 4.6 0 No Yes 5 7 2 1
R:R:L276 R:R:M363 5.65 2 No Yes 5 6 1 1
R:R:T283 R:R:W279 4.85 2 No Yes 8 6 2 1
R:R:M363 R:R:W279 2.33 2 Yes Yes 6 6 1 1
R:R:L287 R:R:T283 2.95 2 No No 6 8 2 2
R:R:T283 R:R:W356 6.06 2 No Yes 8 8 2 1
R:R:L287 R:R:W356 12.53 2 No Yes 6 8 2 1
R:R:C355 R:R:N389 11.02 0 No Yes 8 9 2 1
R:R:N389 R:R:W356 3.39 2 Yes Yes 9 8 1 1
R:R:C382 R:R:L359 3.17 0 No No 5 7 2 1
R:R:L387 R:R:M384 5.65 2 Yes No 7 5 2 2
R:R:N389 R:R:N393 6.81 2 Yes No 9 9 1 2
L:L:?1 R:R:L360 1.67 2 Yes No 0 7 0 1
R:R:I169 R:R:S173 1.55 0 No Yes 5 4 2 1
R:R:D176 R:R:S173 1.47 0 No Yes 3 4 2 1
R:R:I280 R:R:M363 1.46 0 No Yes 5 6 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

ShowSimilarityNetwork TypeNameLigandDescription
75.00Single5ZTYAM102575ZTY-CB2-AM10257
75.00Consensuscb2_offOrthosteric Ligand5ZTY-CB2-AM10257
66.67Single8X3LXWD8X3L-CB2-XWD-Gi1/β1/γ2
65.00Consensusopioid_offOrthosteric Ligandmop_off nop_off dop_off kop_off
63.16Single9I52A1IZU9I52-D1-A1IZU-Gs/β1/γ2
61.90Single7X2DTavapadon7X2D-D1-Tavapadon-Gs/β1/γ2
61.90Single8GAGPubChem 1708384908GAG-CB1-PubChem 170838490-Gi1/β1/γ2
61.90Single8GUTLEI-1028GUT-CB2-LEI-102-Gi1/β1/γ2
60.87Consensuss1p3_on_gpOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
60.00Single9B65KCA9B65-CB1-KCA-Gi1/β1/γ2
58.33Single7TD2LPA7TD2-LPA1-LPA-Gi1/β1/γ2
57.14Single5F8UCyanopindolol5F8U-β1-Cyanopindolol
57.14Single7YITNalfurafine7YIT-κ-Nalfurafine
57.14Single9DGIZ85267113509DGI-CB1-Z8526711350
57.14Consensuscannabinoid_offOrthosteric Ligandcb2_off cb1_off
55.00Single7SBFPZM217SBF-μ-PZM21-Gi1/β1/γ2
54.55Single2YCZIodocyanopindolol2YCZ-β1-Iodocyanopindolol
54.55Single5X93K-87945X93-ETB-K-8794
54.55Single8WRZPubChem 1023367048WRZ-CB1-PubChem 102336704-Arrestin2
54.55Consensuscb1_on_gpOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
54.55Consensusgi_s1pOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7EW3-S1P3-S1P-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EW1-S1P5-Siponimod-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
52.63Single8GUQOlorinab8GUQ-CB2-Olorinab-Gi1/β1/γ2
52.38Single2YDVNECA2YDV-A2A-NECA
52.38Single4UHRCGS216804UHR-A2A-CGS21680
52.38Single5A8E7-Methylcyanopindolol5A8E-β1-7-Methylcyanopindolol-Na
52.38Single5G53NECA5G53-A2A-NECA-Gs
52.38Single7CKYPW04647CKY-D1-PW0464-Gs/β1/γ2
52.38Single7WV9CP559407WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
52.38Single8DZPmomSalB8DZP-κ-momSalB-Gi1/β1/γ2
52.38Single8T1VPubChem 1183102098T1V-GPR6-PubChem 118310209-Na
52.38Single8WU1PubChem 1190256658WU1-CB1-PubChem 119025665-Arrestin2
52.38Single9EGOYVF9EGO-CB1-YVF-Gi1/β1/γ2
52.38Single9I54A1IZV9I54-D1-A1IZV-Gs/β1/γ2
52.38Consensusgi_cannabinoidOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 6KPG-CB1-AM841-Gi1/β1/γ2
52.17Single4UG2CGS216804UG2-A2A-CGS21680
52.17Single7XY6BAY 60-65837XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
52.17Consensuss1p_onOrthosteric Ligands1p1_on s1p3_on s1p5_on
52.17Consensuss1p_on_gpOrthosteric Ligands1p1_on_gp s1p3_on_gp s1p5_on_gp
50.00Single2YCXCyanopindolol2YCX-β1-Cyanopindolol
50.00Single6H7OCyanopindolol6H7O-β1-Cyanopindolol
50.00Single7EW2Fingolimod7EW2-S1P3-Fingolimod-Gi1/β1/γ2
50.00Single7VIES1P7VIE-S1P1-S1P-Gi1/β1/γ2
50.00Single7YMJTamsulosin7YMJ-Alpha1A-Tamsulosin
50.00Single8GHVAMG3158GHV-CB1-AMG315-Gi1/β1/γ2
50.00Single8XVKAmbrisentan8XVK-ETA-Ambrisentan
50.00Single9CHXS-Carazolol9CHX-β2-S-Carazolol
50.00Single9M4TSilodosin9M4T-Alpha1A-Silodosin
50.00Consensusalpha1_offOrthosteric Ligandalpha1a_off
50.00Consensusalpha1a_offOrthosteric Ligand7YMJ-Alpha1A-Tamsulosin
50.00Consensuscannabinoid_onOrthosteric Ligandcb2_on cb1_on
50.00Consensuscannabinoid_on_gpOrthosteric Ligandcb2_on_gp cb1_on_gp
50.00Consensuscb1_onOrthosteric Ligand6KPG-CB1-AM841-Gi1/β1/γ2 8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
50.00Consensusgi_lipidOrthosteric Ligandgi_cannabinoid gi_ffa gi_leukotriene gi_lpa gi_s1p
50.00Consensusgi_opioidOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8F7X-NOP-Nociceptin-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2 8F7S-δ-Deltorphin-Gi1/β1/γ2 8F7W-κ-Dynorphin-Gi1/β1/γ2
50.00Consensusmop_offOrthosteric Ligand4DKL-μ-β-Funaltrexamine 8QOT-μ-Nanobody-E 7UL4-μ-Alvimopan
50.00Consensusmop_onOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
50.00Consensusmop_on_gpOrthosteric Ligand8F7R-μ-Endomorphin-Gi1/β1/γ2 8EF5-μ-Fentanyl-Gi1/β1/γ2 7SCG-μ-FH210-Gi1/β1/γ2 7T2H-μ-Lofentanil-Gi1/β1/γ2 7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2 8EF6-μ-Morphine-Gi1/β1/γ2 8EFB-μ-Oliceridine-Gi1/β1/γ2 7U2L-μ-PubChem 163201242-Gi1/β1/γ2 8EFO-μ-PZM21-Gi1/β1/γ2 8EFL-μ-SR17018-Gi1/β1/γ2 8F7Q-μ-β-Endorphin-Gi1/β1/γ2 7U2K-μ-C6-guano-Gi1/β1/γ2 8EFQ-μ-Damgo-Gi1/β1/γ2
50.00Consensuss1p1_onOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
50.00Consensuss1p1_on_gpOrthosteric Ligand7VIE-S1P1-S1P-Gi1/β1/γ2 7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2 7VIG-S1P1-CBP-307-Gi1/β1/γ2 7EVY-S1P1-Siponimod-Gi1/β1/γ2 7EVZ-S1P1-Cenerimod-Gi1/β1/γ2 7EW0-S1P1-Ozanimod-Gi1/β1/γ2 7EW7-S1P1-SEW2871-Gi1/β1/γ2
48.15Consensusopioid_onOrthosteric Ligandmop_on nop_on dop_on kop_on
47.83Single4BVNCyanopindolol4BVN-β1-Cyanopindolol-Na
47.83Single6DDFDamgo6DDF-μ-Damgo-Gi1/β1/γ2
47.83Single7MTSADX551647MTS-mGlu2; mGlu2-Glutamate-ADX55164-Gi1/β1/γ2
47.83Single7U2KC6-guano7U2K-μ-C6-guano-Gi1/β1/γ2
47.83Single7UM4AS26747237UM4-5-HT5A-AS2674723
47.83Single8E9X2-Deoxycytidine8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2
47.83Single8E9YClozapine-N-oxide8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
47.83Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
47.83Single8S2TIsoprenaline8S2T-β1-Isoprenaline-chim(NtGi1-Gs)/β1/γ2
47.83Consensusendothelin_offOrthosteric Ligandetb_off
47.83Consensusetb_offOrthosteric Ligand5X93-ETB-K-8794 5XPR-ETB-Bosentan 6K1Q-ETB-IRL2500
47.83Consensuskop_on_gpOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
47.62Single2YCWS-Carazolol2YCW-β1-S-Carazolol
47.62Single5D6LS-Carazolol5D6L-β2-S-Carazolol
47.62Single5TVNLSD5TVN-5-HT2B-LSD
47.62Single5X7DS-Carazolol5X7D-β2-S-Carazolol-Cmpd-15
47.62Single5XPRBosentan5XPR-ETB-Bosentan
47.62Single6TO7Suvorexant6TO7-OX1-Suvorexant-Na
47.62Single6TP6Filorexant6TP6-OX1-Filorexant
47.62Single7EPFNAM5977EPF-mGlu2; mGlu2-NAM597
47.62Single7WC6LSD7WC6-5-HT2A-LSD
47.62Single8C9WEtrumadenant8C9W-A2A-Etrumadenant
47.62Single8DZQmomSalB8DZQ-κ-momSalB-Go/β1/γ2
47.62Single8DZRGR89,6968DZR-κ-GR89,696-chim(NtGi2-Gt3)/β1/γ2
47.62Single8EFBOliceridine8EFB-μ-Oliceridine-Gi1/β1/γ2
47.62Single8JXSPF-61428JXS-D1-PF-6142
47.62Single8K8JFenofibrate8K8J-CB1-Fenofibrate-chim(Gs-CtGq)/β1/γ2
47.62Single9EE8Adenosine9EE8-A2A-Adenosine-Gs/β1/γ2
47.62Single9MQKIsoquinuclidine9MQK-κ-Isoquinuclidine
47.62Consensuscb2_onOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
47.62Consensuscb2_on_gpOrthosteric Ligand8GUR-CB2-CP55,940-Gi1/β1/γ2 8GUS-CB2-HU-308-Gi1/β1/γ2 8GUT-CB2-LEI-102-Gi1/β1/γ2 6KPF-CB2-PubChem 145915889-Gi1/β1/γ2 6PT0-CB2-WIN 55212-2-Gi1/β1/γ2 8GUQ-CB2-Olorinab-Gi1/β1/γ2
47.62Consensusd1_onOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
47.62Consensusd4_onOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
47.62Consensuslipid_onOrthosteric Ligandcannabinoid_on ffa_on lpl_on prostanoid_on leukotriene_on
47.62Consensuslipid_on_gpOrthosteric Ligandcannabinoid_on_gp ffa_on_gp lpl_on_gp prostanoid_on_gp leukotriene_on_gp
46.43Consensusopioid_on_gpOrthosteric Ligandmop_on_gp nop_on_gp dop_on_gp kop_on_gp
46.15Single7TD0LPA7TD0-LPA1-LPA-Gi1/β1/γ2
46.15Single8XIQL7967788XIQ-SST3-L796778-chim(NtGi1-Gs-CtGi1)/β1/γ2
46.15Consensusgs_class-aOrthosteric Ligandgs_peptide gs_nucleotide gs_amine
45.83Single3NY9ICI118-5513NY9-β2-ICI118-551
45.83Single7SK9CCX6627SK9-ACKR3-CCX662
45.83Single8X5YAstemizole8X5Y-H1-Astemizole
45.83Single8Y72Peptide8Y72-μ-Peptide-BMS-986122-Gi1/β1/γ2
45.45Single3SN6BI1671073SN6-β2-BI167107-Gs/β1/γ2
45.45Single4DJHJDTic4DJH-κ-JDTic
45.45Single5D5AS-Carazolol5D5A-β2-S-Carazolol
45.45Single5D5BS-Carazolol5D5B-β2-S-Carazolol
45.45Single5XR8AM8415XR8-CB1-AM841
45.45Single5XRAAM115425XRA-CB1-AM11542
45.45Single5ZKBAF-DX 3845ZKB-M2-AF-DX 384
45.45Single6GT3Imaradenant6GT3-A2A-Imaradenant-Na
45.45Single6H7JIsoprenaline6H7J-β1-Isoprenaline
45.45Single6J21Aprepitant6J21-NK1-Aprepitant
45.45Single6N4BMDMB-Fubinaca6N4B-CB1-MDMB-Fubinaca-Gi1/β1/γ2
45.45Single6TQ7SB-3348676TQ7-OX1-SB-334867
45.45Single7EW7SEW28717EW7-S1P1-SEW2871-Gi1/β1/γ2
45.45Single7FEECP559407FEE-CB1-CP55940-ZCZ011
45.45Single7JJOIsoprenaline7JJO-β1-Isoprenaline-Gs/β1/γ2
45.45Single7JVPSKF839597JVP-D1-SKF83959-Gs/β1/γ2
45.45Single7T2HLofentanil7T2H-μ-Lofentanil-Gi1/β1/γ2
45.45Single7U2LPubChem 1632012427U2L-μ-PubChem 163201242-Gi1/β1/γ2
45.45Single7VIGCBP-3077VIG-S1P1-CBP-307-Gi1/β1/γ2
45.45Single8DCSCyanopindolol8DCS-β1-Cyanopindolol-Gs/β1/γ2
45.45Single8E0GBU728E0G-μ-BU72
45.45Single8EF5Fentanyl8EF5-μ-Fentanyl-Gi1/β1/γ2
45.45Single8IRURotigotine8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
45.45Single8VVFJDTic8VVF-κ-JDTic-Gi1/β1/γ2
45.45Single8Y73Peptide8Y73-μ-Peptide-MPAM-15-Gi1/β1/γ2
45.45Single9BJKNaloxone9BJK-μ-Naloxone-NAM
45.45Single9IJDCarazolol9IJD-β3-Carazolol-chim(NtGi1-Gs)/β1/γ2
45.45Consensusa2_onOrthosteric Liganda2b_on
45.45Consensusa2_on_gpOrthosteric Liganda2b_on_gp
45.45Consensusa2b_onOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
45.45Consensusa2b_on_gpOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2
45.45Consensusbeta1_offOrthosteric Ligand2VT4-β1-Cyanopindolol 2YCW-β1-S-Carazolol 2YCZ-β1-Iodocyanopindolol 5A8E-β1-7-Methylcyanopindolol-Na 3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na 3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
45.45Consensusd1_on_gpOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2
45.45Consensusd4_on_gpOrthosteric Ligand8IRU-D4-Rotigotine-chim(NtGi1-Gs-CtGi1)/β1/γ2
45.45Consensusgs_adenosineOrthosteric Ligand8HDP-A2B-Adenosine-Gs/β1/γ2 8HDO-A2B-BAY 60-6583-Gs/β1/γ2 7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2 7XY6-A2B-BAY 60-6583-chim(NtGi1-Gs)/β1/γ2
45.45Consensusgs_dopamineOrthosteric Ligand7F0T-D1-Dopamine-Gs/β1/γ2 7CKW-D1-Fenoldopam-Gs/β1/γ2 7CKY-D1-PW0464-Gs/β1/γ2 8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2 8IRR-D1-Rotigotine-Gs/β1/γ2 7JV5-D1-SKF81297-Gs/β1/γ2 7JVP-D1-SKF83959-Gs/β1/γ2 7X2D-D1-Tavapadon-Gs/β1/γ2 7CKX-D1-A77636-Gs/β1/γ2 7JVQ-D1-Apomorphine-Gs/β1/γ2
45.45Consensusgs_nucleotideOrthosteric Ligandgs_adenosine
45.45Consensuskop_offOrthosteric Ligand4DJH-κ-JDTic
45.00Single6PT0WIN 55212-26PT0-CB2-WIN 55212-2-Gi1/β1/γ2
45.00Single6TPGEMPA6TPG-OX2-EMPA
45.00Single6TPNHTL66416TPN-OX2-HTL6641
45.00Single7SR8TAK-9257SR8-OX2-TAK-925-chim(NtGi1L-Gs-CtGq)/β1/γ2
45.00Single8GURCP55,9408GUR-CB2-CP55,940-Gi1/β1/γ2
45.00Single8THLEpinephrine8THL-Alpha1A-Epinephrine-chim(NtGi2L-Gs-CtGq)/β1/γ2
45.00Single8WC8ZH86518WC8-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
45.00Single9MQIIsoquinuclidine9MQI-μ-Isoquinuclidine
45.00Consensusalpha1_onOrthosteric Ligandalpha1a_on
45.00Consensusalpha1_on_gpOrthosteric Ligandalpha1a_on_gp
45.00Consensusalpha1a_onOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
45.00Consensusalpha1a_on_gpOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2
44.83Single7F4FAfamelanotide7F4F-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
44.83Single8FEG(DNCP)-Beta-Naloxamine8FEG-κ-(DNCP)-β-Naloxamine-Gi1/β1/γ2
44.44Single7KH0AVP7KH0-V2-AVP-chim(NtGi1-Gs)/β1/γ2
44.00Single4AMJS-Carvedilol4AMJ-β1-S-Carvedilol
44.00Single7F4ISHU91197F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
44.00Single7TD4Siponimod7TD4-S1P1-Siponimod-Gi1/β1/γ2
44.00Single8DCRDobutamine8DCR-β1-Dobutamine-Gs/β1/γ2
44.00Single8PKMBefiradol8PKM-5-HT1A-Befiradol-Gi1/β1/γ1
44.00Single8WDTphotoNECA8WDT-A2A-photoNECA
44.00Consensusclass-a_on_gpOrthosteric Ligandsensory_on_gp alicarboxylic_on_gp amine_on_gp lipid_on_gp nucleotide_on_gp peptide_on_gp protein_on_gp
44.00Consensuslpl_onOrthosteric Ligands1p_on lpa_on
44.00Consensuslpl_on_gpOrthosteric Ligands1p_on_gp lpa_on_gp
43.48Single3D4STimolol3D4S-β2-Timolol
43.48Single4AMIBucindolol4AMI-β1-Bucindolol
43.48Single4LDEBI1671074LDE-β2-BI167107
43.48Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
43.48Single4RWADIPP-NH24RWA-δ-DIPP-NH2
43.48Single6KPGAM8416KPG-CB1-AM841-Gi1/β1/γ2
43.48Single6KQICP559406KQI-CB1-CP55940-Org27569
43.48Single7EO4BAF3127EO4-S1P1-BAF312-Gi1/β1/γ2
43.48Single7EXDLasmiditan7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
43.48Single7MTRADX551647MTR-mGlu2; mGlu2-Glutamate-ADX55164
43.48Single8FYTLSD8FYT-5-HT1A-LSD-Gi1/β1/γ1
43.48Single8JWY2-1188JWY-A2A-2-118
43.48Single8JWZAB9288JWZ-A2A-AB928-Na
43.48Single9EBIPiclidenoson9EBI-A3A-Piclidenoson-chim(NtGi1L-Gs-CtGi1)/β1/γ2
43.48Single9GYOP3959GYO-GPBA-P395-chim(NtGi1-Gs)/β1/γ2
43.48Single9IZHLPA9IZH-LPA1-LPA-chim(NtGi2-G13)/β1/γ2
43.48Single9M4QDoxazosin9M4Q-Alpha1A-Doxazosin
43.48Single9MQLIsoquinuclidine9MQL-κ-Isoquinuclidine
43.48Consensus5ht1f_onOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
43.48Consensus5ht1f_on_gpOrthosteric Ligand7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2
43.48Consensusgi_amineOrthosteric Ligandgi_5ht gi_muscarinic gi_adrenergic gi_dopamine gi_histamine
43.48Consensuskop_onOrthosteric Ligand8F7W-κ-Dynorphin-Gi1/β1/γ2 8DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2 8DZP-κ-momSalB-Gi1/β1/γ2
43.48Consensuslipid_offonOrthosteric Ligandlipid_off lipid_on
43.48Consensuslipid_offon_gpOrthosteric Ligandlipid_on_gp lipid_off
43.48Consensuslpl_offOrthosteric Ligands1p_off lpa_off
43.48Consensuss1p3_onOrthosteric Ligand7EW3-S1P3-S1P-Gi1/β1/γ2 7EW4-S1P3-CYM5541-Gi1/β1/γ2 7EW2-S1P3-Fingolimod-Gi1/β1/γ2
42.86Single2Y04Salbutamol2Y04-β1-Salbutamol
42.86Single3NY8ICI118-5513NY8-β2-ICI118-551
42.86Single3ZPQ4-(piperazin-1- yl)-1H-indole3ZPQ-β1-4-(piperazin-1- yl)-1H-indole-Na
42.86Single3ZPR4-methyl-2-(piperazin-1-yl)3ZPR-β1-4-methyl-2-(piperazin-1-yl)-Na
42.86Single4EJ4Naltrindole4EJ4-δ-Naltrindole
42.86Single4GBRS-Carazolol4GBR-β2-S-Carazolol
42.86Single5OLZPubChem 1355666095OLZ-A2A-PubChem 135566609-Na
42.86Single5OM1PubChem 1355666095OM1-A2A-PubChem 135566609-Na
42.86Single6DRXLisuride6DRX-5-HT2B-Lisuride
42.86Single6KPFPubChem 1459158896KPF-CB2-PubChem 145915889-Gi1/β1/γ2
42.86Single6PS2S-Alprenolol6PS2-β2-S-Alprenolol
42.86Single6TOTLemborexant6TOT-OX1-Lemborexant
42.86Single7CRHSKF839597CRH-D1-SKF83959-Gs/β1/γ2
42.86Single7JOZVFP7JOZ-D1-VFP-Gs/β1/γ2
42.86Single7JVQApomorphine7JVQ-D1-Apomorphine-Gs/β1/γ2
42.86Single7S0GIsoprenaline7S0G-β1-Isoprenaline-chim(Gi1-CtGs)/β1/γ2
42.86Single7UM6Lisuride7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
42.86Single7V3ZCP559407V3Z-CB1-CP55940
42.86Single7WC7Lisuride7WC7-5-HT2A-Lisuride
42.86Single7XJHIsoproterenol7XJH-β3-Isoproterenol-Gs/β1/γ2
42.86Single7XTC5-CT7XTC-5-HT7-5-CT-Gs/β1/γ2
42.86Single8CICEtrumadenant8CIC-A2A-Etrumadenant-Na
42.86Single8DZSGR89,6968DZS-κ-GR89,696-chim(NtGi2-Gz)/β1/γ2
42.86Single8JD0NAM5638JD0-mGlu2; mGlu3-Glutamate-NAM563
42.86Single8JLZST19368JLZ-5-HT6-ST1936-Gs/β1/γ2
42.86Single8JXRLSD8JXR-D1-LSD
42.86Single8T1WCVN4248T1W-GPR6-CVN424
42.86Single8UH3Setiptiline8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
42.86Single8VVGGB188VVG-κ-GB18-Gi1/β1/γ2
42.86Single8W87METH8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2
42.86Single8XGOTAK4488XGO-Kiss1-TAK448-chim(NtGi1-Gq)/β1/γ2
42.86Single8ZSSRO52633978ZSS-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
42.86Single9BQJRO769BQJ-μ-RO76-Gi1/β1/γ2
42.86Single9CBMDexmedetomidine9CBM-α2a-Dexmedetomidine-Gi1/β1/γ2
42.86Single9D61JDTic9D61-κ-JDTic-Gi1/β1/γ2
42.86Single9PLNN-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLN-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine
42.86Single9PLON-(5-methylnaphthalen-1-yl)pyridin-4-amine9PLO-α2a-N-(5-methylnaphthalen-1-yl)pyridin-4-amine-Go/β1/γ2
42.86Consensus5ht5_onOrthosteric Ligand5ht5a_on
42.86Consensus5ht5a_onOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
42.86Consensus5ht6_onOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
42.86Consensus5ht6_on_gpOrthosteric Ligand7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2
42.86Consensus5ht7_onOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
42.86Consensus5ht7_on_gpOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2
42.86Consensusalpha_onOrthosteric Ligandalpha1_on alpha2_on
42.86Consensusdop_offOrthosteric Ligand4EJ4-δ-Naltrindole
42.86Consensusdopamine_offOrthosteric Ligandd2_off d3_off
42.86Consensusgs_trace-amineOrthosteric Ligand8W88-TA1-SEP-363856-Gs/β1/γ2 8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2 8WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
42.31Single3QAKUK-4320973QAK-A2A-UK-432097
42.31Single8F7SDeltorphin8F7S-δ-Deltorphin-Gi1/β1/γ2
42.31Single8F7WDynorphin8F7W-κ-Dynorphin-Gi1/β1/γ2
42.31Consensusdop_on_gpOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
42.11Single7XTASerotonin7XTA-5-HT4-Serotonin-Gi1/β1/γ2
42.11Single8ZSVRO52633978ZSV-TA1-RO5263397-chim(NtGi1-Gs)/β1/γ2
42.11Consensus5ht4_onOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
42.11Consensus5ht4_on_gpOrthosteric Ligand7XTA-5-HT4-Serotonin-Gi1/β1/γ2
41.67Single4OR2FITM4OR2-mGlu1; mGlu1-FITM
41.67Single4Z35ONO-99105394Z35-LPA1-ONO-9910539
41.67Single6K1QIRL25006K1Q-ETB-IRL2500
41.67Single7EVZCenerimod7EVZ-S1P1-Cenerimod-Gi1/β1/γ2
41.67Single7EW0Ozanimod7EW0-S1P1-Ozanimod-Gi1/β1/γ2
41.67Single7VGY2-Iodomelatonin7VGY-MT1-2-Iodomelatonin-Gi1/β1/γ2
41.67Single7XJISolabegron7XJI-β3-Solabegron-Gs/β1/γ2
41.67Single7YU8ONO-07405567YU8-LPA1-ONO-0740556-Gi1/β1/γ2
41.67Single8ID8TUG-8918ID8-FFA4-TUG-891-Gi1/β1/γ2
41.67Single8XGSMetastin8XGS-Kiss1-Metastin-chim(NtGi1-Gq)/β1/γ2
41.67Single8XIOL7975918XIO-SST1-L797591-chim(NtGi1-Gs-CtGi1)/β1/γ2
41.67Single9CGJC6-Quino9CGJ-δ-C6-Quino-Gi1/β1/γ2
41.67Single9IZFNKP9IZF-LPA1-NKP-Gi1/β1/γ2
41.67Consensusclass-a_onOrthosteric Ligandsensory_on alicarboxylic_on amine_on lipid_on nucleotide_on peptide_on protein_on
41.67Consensuspeptide_offOrthosteric Ligandcck_off angiotensin_off bombesin_off endothelin_off ghrelin_off npy_off opioid_off orexin_off somatostatin_off tachykinin_off vasop-oxy_off neurotensin_off
40.91Single2RH1S-Carazolol2RH1-β2-S-Carazolol
40.91Single2Y03Isoprenaline2Y03-β1-Isoprenaline
40.91Single4RWDDIPP-NH24RWD-δ-DIPP-NH2-Na
40.91Single4ZJ8Suvorexant4ZJ8-OX1-Suvorexant
40.91Single5C1MBU725C1M-μ-BU72
40.91Single5JQHS-Carazolol5JQH-β2-S-Carazolol
40.91Single5OM4PubChem 1355666095OM4-A2A-PubChem 135566609-Na
40.91Single5WQCEMPA5WQC-OX2-EMPA
40.91Single5ZK33-quinuclidinyl-benzilate5ZK3-M2-3-quinuclidinyl-benzilate
40.91Single6E67BI1671076E67-β2-BI167107-Gs(CT)
40.91Single6GDGNECA6GDG-A2A-NECA-Gs/β1/γ1
40.91Single6KPCPubChem 1459158896KPC-CB2-PubChem 145915889
40.91Single6KUWPubChem 572132346KUW-α2c-PubChem 57213234
40.91Single6ME82-Phenylmelatonin6ME8-MT2-2-Phenylmelatonin
40.91Single6PS3S-Carvedilol6PS3-β2-S-Carvedilol
40.91Single6PS6Timolol6PS6-β2-Timolol
40.91Single7BVQS-Carazolol7BVQ-β1-S-Carazolol
40.91Single7C4SS1P7C4S-S1P3-S1P
40.91Single7CFNINT-7777CFN-GPBA-INT-777-Gs/β1/γ2
40.91Single7CKXA776367CKX-D1-A77636-Gs/β1/γ2
40.91Single7EO2FTY720-P7EO2-S1P1-FTY720-P-Gi1/β1/γ2
40.91Single7LD3Adenosine7LD3-A1-Adenosine-MIPS521-Gi2/β1/γ2
40.91Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
40.91Single7S0FIsoprenaline7S0F-β1-Isoprenaline-Gi1/β1/γ2
40.91Single7TD3S1P7TD3-S1P1-S1P-Gi1/β1/γ2
40.91Single7W41PD1762527W41-BB2-PD176252
40.91Single7XK9Constrained Isoproterenol7XK9-β2-Constrained Isoproterenol-Na
40.91Single8J18(3R)-3-Hydroxydodecanoic acid8J18-GPR84-(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ2
40.91Single8J6JGSK2560738J6J-HCA2-GSK256073-Gi1/β1/γ2
40.91Single8SZGCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZG-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine-chim(NtGi1-Gq)/β1/γ2
40.91Single8YICSAR2477998YIC-S1P1-SAR247799-Gi1/β1/γ2
40.91Single9F33FOB02-04A9F33-D3-FOB02-04A-Go/β1/γ2
40.91Single9K07DSO-5a9K07-BB3-DSO-5a-chim(NtGi2L-Gs-CtGq)/β1/γ2
40.91Consensus5ht5_on_gpOrthosteric Ligand5ht5a_on_gp
40.91Consensus5ht5a_on_gpOrthosteric Ligand7X5H-5-HT5A-5-CT-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
40.91Consensusadrenergic_offOrthosteric Ligandalpha_off beta_off
40.91Consensusadrenergic_on_gpOrthosteric Ligandalpha_on_gp beta_on_gp
40.91Consensusalpha2c_offOrthosteric Ligand6KUW-α2c-PubChem 57213234
40.91Consensusalpha_offOrthosteric Ligandalpha1_off alpha2_off
40.91Consensusalpha_on_gpOrthosteric Ligandalpha1_on_gp alpha2_on_gp
40.91Consensusamine_offOrthosteric Ligand5ht_off adrenergic_off dopamine_off histamine_off muscarinic_off
40.91Consensusamine_offonOrthosteric Ligandamine_off amine_on
40.91Consensusamine_offon_gpOrthosteric Ligandamine_on_gp amine_off
40.91Consensusamine_onOrthosteric Ligand5ht_on adrenergic_on dopamine_on histamine_on muscarinic_on trace-amine_on
40.91Consensusbb2_offOrthosteric Ligand7W41-BB2-PD176252
40.91Consensusbeta2_offOrthosteric Ligand2RH1-β2-S-Carazolol 6PS3-β2-S-Carvedilol 6PS5-β2-S-Propranolol 3D4S-β2-Timolol 3NY8-β2-ICI118-551 3NY9-β2-ICI118-551 6PRZ-β2-S-Alprenolol
40.91Consensusbeta_offOrthosteric Ligandbeta1_off beta2_off
40.91Consensusbombesin_offOrthosteric Ligandbb2_off
40.91Consensusgi_adrenergicOrthosteric Ligand7EJ0-α2a-L-Norepinephrine-Go/β1/γ2 7EJK-α2a-Oxymetazoline-Go/β1/γ2 7W7E-α2a-PubChem 164946676-Go/β1/γ2 7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2 7EJ8-α2a-Brimonidine-Go/β1/γ2 6K42-α2b-Dexmedetomidine-Gi1/β1/γ2 7EJA-α2a-Dexmedetomidine-Go/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
40.91Consensusgs_amineOrthosteric Ligandgs_5ht gs_adrenergic gs_dopamine gs_histamine gs_trace-amine
40.91Consensush1_offOrthosteric Ligand8X63-H1-Mepyramine 3RZE-H1-Cidoxepin 8X5Y-H1-Astemizole
40.91Consensuss1p_offOrthosteric Ligands1p1_off s1p5_off
40.91Consensusta1_onOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
40.91Consensustrace-amine_onOrthosteric Ligandta1_on
40.74Single6PT2KGCHM076PT2-δ-KGCHM07
40.74Single8XGUTAK4488XGU-Kiss1-TAK448-Gi1/β1/γ2
40.00Single6AKXA4R6AKX-CCR5-A4R
40.00Single6B73MP11046B73-κ-MP1104
40.00Single6G79Donitriptan6G79-5-HT1B-Donitriptan-Go/β1/γ2
40.00Single6OBAS-Alprenolol6OBA-β2-S-Alprenolol-GTPL11074
40.00Single6PT3DPI-2876PT3-δ-DPI-287
40.00Single6TQ6PubChem 1457142836TQ6-OX1-PubChem 145714283
40.00Single7F1ODopamine7F1O-D1-Dopamine-GDP; Mg-Gs/β1/γ2
40.00Single7SRRLSD7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
40.00Single7SRSLSD7SRS-5-HT2B-LSD-Arrestin2
40.00Single7YM8Oxymetazoline7YM8-Alpha1A-Oxymetazoline-chim(Gs-CtGq)
40.00Single8EFOPZM218EFO-μ-PZM21-Gi1/β1/γ2
40.00Single8F7REndomorphin8F7R-μ-Endomorphin-Gi1/β1/γ2
40.00Single8JLRA776368JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2
40.00Single8JSOAMPH8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2
40.00Single8WC4ZH86518WC4-TA1-ZH8651-chim(NtGi1-Gs)/β1/γ2
40.00Single8WCA2-Phenylethylamine8WCA-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
40.00Single8Y0HVUF114188Y0H-CXCR3-VUF11418
40.00Single8Y0NVUF114188Y0N-CXCR3-VUF11418-Go/β1/γ2
40.00Single8ZH8QRF-Amide8ZH8-QRFP-QRF-Amide-Gq/β1/γ1
40.00Single9CGKC5-Quino9CGK-δ-C5-Quino-Gi1/β1/γ2
40.00Single9J5VCpY9J5V-LPA1-CpY-Gi1/β1/γ2
40.00Single9K26PrRP319K26-PrRP-PrRP31-Gi1/β1/γ2
40.00Single9KDFRES-701-39KDF-ETB-RES-701-3
40.00Single9M0RNeuropeptide VF9M0R-NPFF1-Neuropeptide VF-Gi1/β1/γ2
40.00Single9MQJIsoquinuclidine9MQJ-μ-Isoquinuclidine
40.00Single9V2NMacimorelin9V2N-Ghrelin-Macimorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Consensus5ht2_on_gpOrthosteric Ligand5ht2b_on_gp
40.00Consensus5ht2b_on_gpOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
40.00Consensusdop_onOrthosteric Ligand8F7S-δ-Deltorphin-Gi1/β1/γ2
40.00Consensusorexin_offOrthosteric Ligandox2_off ox1_off
40.00Consensusox2_offOrthosteric Ligand5WQC-OX2-EMPA 6TPN-OX2-HTL6641 7XRR-OX2-Lemborexant 6TPJ-OX2-Suvorexant
40.00Consensusox2_onOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
40.00Consensusox2_on_gpOrthosteric Ligand7L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2 7SQO-OX2-TAK-925-Gi1/β1/γ2 7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
39.29Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
39.29Single8H4KGW95088H4K-FFA4-GW9508-chim(NtGi1-Gs-CtGq)/β1/γ2
39.29Single8ZBISomatostatin-148ZBI-SST3-Somatostatin-14-Gi1/β1/γ2
39.29Consensuscxcr3_on_gpOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
39.29Consensusgi_class-aOrthosteric Ligandgi_peptide gi_sensory gi_alicarboxylic gi_amine gi_lipid gi_nucleotide gi_protein
39.13Single3P0GBI1671073P0G-β2-BI167107
39.13Single3UON3-quinuclidinyl-benzilate3UON-M2-3-quinuclidinyl-benzilate
39.13Single4U15Tiotropium4U15-M3-Tiotropium
39.13Single4Z34ONO-97803074Z34-LPA1-ONO-9780307
39.13Single5ZHPPubChem 1348285895ZHP-M3-PubChem 134828589
39.13Single6DDEDamgo6DDE-μ-Damgo-Gi1/β1/γ2
39.13Single6E59L-7607356E59-NK1-L-760735
39.13Single6J20Aprepitant6J20-NK1-Aprepitant
39.13Single6N48BI1671076N48-β2-BI167107-PubChem 138454256
39.13Single6NI3BI1671076NI3-β2-BI167107-Gs/β1/γ2
39.13Single6OL9Tiotropium6OL9-M5-Tiotropium
39.13Single6WGTLSD6WGT-5-HT2A-LSD
39.13Single7B6WCyclazosin7B6W-α1b-Cyclazosin
39.13Single7E2ZAripiprazole7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2
39.13Single7EW3S1P7EW3-S1P3-S1P-Gi1/β1/γ2
39.13Single7JV5SKF812977JV5-D1-SKF81297-Gs/β1/γ2
39.13Single7W6PN-pyridin-4-ylisoquinolin-4-amine7W6P-α2a-N-pyridin-4-ylisoquinolin-4-amine-Go/β1/γ2
39.13Single7W7EPubChem 1649466767W7E-α2a-PubChem 164946676-Go/β1/γ2
39.13Single7XY7NECA7XY7-A2B-NECA-chim(NtGi1-Gs)/β1/γ2
39.13Single7YU7ONO-07405567YU7-LPA1-ONO-0740556-Gi1/β1/γ2
39.13Single8EFLSR170188EFL-μ-SR17018-Gi1/β1/γ2
39.13Single8GUSHU-3088GUS-CB2-HU-308-Gi1/β1/γ2
39.13Single8HDOBAY 60-65838HDO-A2B-BAY 60-6583-Gs/β1/γ2
39.13Single8ID39-Hydroxystearic acid8ID3-FFA4-9-Hydroxystearic acid-Gi1/β1/γ2
39.13Single8IRRRotigotine8IRR-D1-Rotigotine-Gs/β1/γ2
39.13Single8IRVRotigotine8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
39.13Single8JT6(R)-IHCH-71798JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2
39.13Single8JXVClozapine8JXV-H4-Clozapine-Gi1/β1/γ2
39.13Single8JXXClobenpropit8JXX-H4-Clobenpropit-Gi1/β1/γ2
39.13Single8XVLZibotentan8XVL-ETA-Zibotentan
39.13Consensusamine_on_gpOrthosteric Ligand5ht_on_gp adrenergic_on_gp dopamine_on_gp histamine_on_gp muscarinic_on_gp trace-amine_on_gp
39.13Consensusbeta2_onOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
39.13Consensusbeta2_on_gpOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2
39.13Consensusclass-a_offOrthosteric Ligandsensory_off alicarboxylic_off amine_off lipid_off nucleotide_off peptide_off protein_off
39.13Consensusd5_on_gpOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
39.13Consensusm3_offOrthosteric Ligand4U15-M3-Tiotropium 4U16-M3-N-Methyl-Scopolamine 5ZHP-M3-PubChem 134828589
39.13Consensusm5_offOrthosteric Ligand6OL9-M5-Tiotropium
39.13Consensusmuscarinic_offOrthosteric Ligandm2_off m3_off m4_off m5_off m1_off
39.13Consensusta1_on_gpOrthosteric Ligand8W87-TA1-METH-chim(NtGi1L-Gs)/β1/γ2 8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2 8JLP-TA1-Ralmitaront-Gs/β1/γ2 8W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2 8W88-TA1-SEP-363856-Gs/β1/γ2 8JLO-TA1-Ulotaront-Gs/β1/γ2 8JLR-TA1-A77636-chim(NtGi1-Gs)/β1/γ2 8JSO-TA1-AMPH-chim(NtGi1-Gs)/β1/γ2 8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
39.13Consensustrace-amine_on_gpOrthosteric Ligandta1_on_gp
38.46Single7QA8Peptide7QA8-STE2-Peptide
38.46Single7QA8Peptide7QA8-STE2-Peptide
38.46Single7WVWfMYFINILTL7WVW-FPR2-ALX-fMYFINILTL-Gi2/β1/γ2
38.46Single8F7XNociceptin8F7X-NOP-Nociceptin-Gi1/β1/γ2
38.46Single8FYLVilazodone8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
38.46Single8G59TUG-8918G59-FFA4-TUG-891-chim(Gi1-CtGq)/β1/γ2
38.46Single8ZSPLSD8ZSP-TA1-LSD-chim(NtGi1L-Gs-CtGq)/β1/γ2
38.46Consensusnop_onOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
38.46Consensusnop_on_gpOrthosteric Ligand8F7X-NOP-Nociceptin-Gi1/β1/γ2
38.10Single2YDOAdenosine2YDO-A2A-Adenosine
38.10Single3V2YPubChem 518926453V2Y-S1P1-PubChem 51892645
38.10Single4DKLBeta-Funaltrexamine4DKL-μ-β-Funaltrexamine
38.10Single4LDOL-Epinephrine4LDO-β2-L-Epinephrine
38.10Single4MBSMaraviroc4MBS-CCR5-Maraviroc
38.10Single4N6HNaltrindole4N6H-δ-Naltrindole-Na
38.10Single4ZJCSB-6740424ZJC-OX1-SB-674042
38.10Single6K41Dexmedetomidine6K41-α2b-Dexmedetomidine-Go/β1/γ2
38.10Single6PS0S-Carazolol6PS0-β2-S-Carazolol
38.10Single6PS4ICI118-5516PS4-β2-ICI118-551
38.10Single6PS5S-Propranolol6PS5-β2-S-Propranolol
38.10Single6TOSGSK10598656TOS-OX1-GSK1059865-Na
38.10Single6TP3Nemorexant6TP3-OX1-Nemorexant
38.10Single6WJCAtropine6WJC-M1-Atropine-Muscarinic toxin 7
38.10Single7CKWFenoldopam7CKW-D1-Fenoldopam-Gs/β1/γ2
38.10Single7CKZDopamine7CKZ-D1-Dopamine-Mevidalen-Gs/β1/γ2
38.10Single7CMUPramipexole7CMU-D3-Pramipexole-Gi1/β1/γ2
38.10Single7CMVPD1289077CMV-D3-PD128907-Gi1/β1/γ2
38.10Single7E33BRL-544437E33-5-HT1E-BRL-54443-Gi1/β1/γ2
38.10Single7EJ8Brimonidine7EJ8-α2a-Brimonidine-Go/β1/γ2
38.10Single7EJADexmedetomidine7EJA-α2a-Dexmedetomidine-Go/β1/γ2
38.10Single7F0TDopamine7F0T-D1-Dopamine-Gs/β1/γ2
38.10Single7RANPubChem 1645758477RAN-5-HT2A-PubChem 164575847-chim(NtGi2L-Gs-CtGq)/β1/γ2
38.10Single7UM7Methylergometrine7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2
38.10Single8GG7Constrained Epinephrine8GG7-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.10Single8GGLConstrained Epinephrine8GGL-β2-Constrained Epinephrine
38.10Single8GGMConstrained Epinephrine8GGM-β2-Constrained Epinephrine
38.10Single8GGPConstrained Epinephrine8GGP-β2-Constrained Epinephrine
38.10Single8GGQConstrained Epinephrine8GGQ-β2-Constrained Epinephrine
38.10Single8GGXConstrained Epinephrine8GGX-β2-Constrained Epinephrine
38.10Single8HNMVUF112228HNM-CXCR3-VUF11222-Gi1/β1/γ2
38.10Single8JLKUlotaront8JLK-TA1-Ulotaront-chim(NtGi1-Gs)/β1/γ2
38.10Single8JLQFenoldopam8JLQ-TA1-Fenoldopam-Gs/β1/γ2
38.10Single8K9KDamgo8K9K-μ-Damgo-Gi3/β1/γ1
38.10Single8THKA616038THK-Alpha1A-A61603-chim(NtGi2L-Gs-CtGq)/β1/γ2
38.10Single8U02L-Dopamine8U02-D2-L-Dopamine-Go/β1/γ2
38.10Single8UNLConstrained Epinephrine8UNL-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.10Single8UNOConstrained Epinephrine8UNO-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
38.10Single8W88SEP-3638568W88-TA1-SEP-363856-Gs/β1/γ2
38.10Single8Y53MK50468Y53-BB3-MK5046-chim(NtGi1-Gs-CtGq)/β1/γ2
38.10Single8YN3Histamine8YN3-H2-Histamine-Gs/β1/γ2
38.10Single8ZMGPimavanserin8ZMG-5-HT2A-Pimavanserin
38.10Single9ARXSerotonin9ARX-5-HT2A-Serotonin
38.10Single9EPQ11,20-Ethanoretinal9EPQ-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
38.10Single9M2FNeuropeptide FF9M2F-NPFF1-Neuropeptide FF-Gi1/β1/γ2
38.10Consensus5ht_on_gpOrthosteric Ligand5ht1_on_gp 5ht2_on_gp 5ht4_on_gp 5ht5_on_gp 5ht6_on_gp 5ht7_on_gp
38.10Consensusd3_onOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
38.10Consensusd3_on_gpOrthosteric Ligand7CMV-D3-PD128907-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2
38.10Consensusghrelin_offOrthosteric Ligand6KO5-Ghrelin-PubChem 57400002 7F83-Ghrelin-PF-05190457
37.93Single8ZPSPrRP208ZPS-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
37.93Consensusmc1_onOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
37.93Consensusmc1_on_gpOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2
37.93Consensussst5_on_gpOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
37.50Single4Z36ONO-30805734Z36-LPA1-ONO-3080573
37.50Single5CXVTiotropium5CXV-M1-Tiotropium
37.50Single5UNHPubChem 1264564065UNH-AT2-PubChem 126456406
37.50Single6H7NS-Xamoterol6H7N-β1-S-Xamoterol
37.50Single6XBLCholesterol6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
37.50Single7DFPSpiperone7DFP-D2-Spiperone
37.50Single7DH5Mirabegron7DH5-β3-Mirabegron-Gs/β1/γ2
37.50Single7EPENAM5637EPE-mGlu2; mGlu2-NAM563
37.50Single7EVYSiponimod7EVY-S1P1-Siponimod-Gi1/β1/γ2
37.50Single7JNIOlodanrigan7JNI-AT2-Olodanrigan
37.50Single7L1VPubChem 1554910097L1V-OX2-PubChem 155491009-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Single7XMTJ-21567XMT-SST4-J-2156-Gi1/β1/γ2
37.50Single8E9W2-Deoxycytidine8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2
37.50Single8FYE4-F,5-MeO-PyrT8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1
37.50Single8G056-OAU8G05-GPR84-6-OAU-Gi1/β1/γ2
37.50Single8I9AEP548I9A-C3aB-EP54-chim(NtGi1-Gs-CtGq)/β1/γ2
37.50Single8IA8E7 peptide8IA8-C3aB-E7 peptide-Gi1/β1/γ2
37.50Single8ID9Eicosapentaenoic acid8ID9-FFA4-Eicosapentaenoic acid-Gi1/β1/γ2
37.50Single8IRSRotigotine8IRS-D2-Rotigotine-Gi1/β1/γ2
37.50Single8JJ8Formoterol8JJ8-β2-Formoterol
37.50Single8JJLOlodaterol8JJL-β2-Olodaterol
37.50Single8W1VPubChem 1717162658W1V-β2-PubChem 171716265
37.50Single8X8NOctreotide8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
37.50Single8XYIVUF106618XYI-CXCR3-VUF10661
37.50Single9GL2Befiradol9GL2-5-HT1A-Befiradol-Gs/β1/γ2
37.50Consensusbb2_onOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
37.50Consensusbb2_on_gpOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
37.50Consensusbeta3_onOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
37.50Consensusbeta3_on_gpOrthosteric Ligand7DH5-β3-Mirabegron-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2
37.50Consensusbeta_onOrthosteric Ligandbeta1_on beta2_on beta3_on
37.50Consensusbeta_on_gpOrthosteric Ligandbeta1_on_gp beta2_on_gp beta3_on_gp
37.50Consensusbombesin_onOrthosteric Ligandbb2_on
37.50Consensusbombesin_on_gpOrthosteric Ligandbb2_on_gp
37.50Consensusgq_bombesinOrthosteric Ligand7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2 7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
37.50Consensusleukotriene_offOrthosteric Ligandblt_off cyslt_off
37.50Consensuslpa1_offOrthosteric Ligand4Z36-LPA1-ONO-3080573 4Z35-LPA1-ONO-9910539 4Z34-LPA1-ONO-9780307
37.50Consensuslpa_offOrthosteric Ligandlpa1_off
37.50Consensusm1_offOrthosteric Ligand5CXV-M1-Tiotropium
37.50Consensusnk1_offOrthosteric Ligand6HLP-NK1-Netupitant 6HLO-NK1-Aprepitant 6HLL-NK1-CP99994 6E59-NK1-L-760735
37.50Consensusorexin_onOrthosteric Ligandox2_on
37.04Single6HLOAprepitant6HLO-NK1-Aprepitant
37.04Single7DDZJNJ-310200287DDZ-Y2-JNJ-31020028
37.04Consensusnpy2_offOrthosteric Ligand7DDZ-Y2-JNJ-31020028
36.84Single8POKHistamine8POK-H2-Histamine-Gs/β1/γ2
36.84Consensus5ht2_onOrthosteric Ligand5ht2b_on
36.84Consensus5ht2b_onOrthosteric Ligand7SRR-5-HT2B-LSD-chim(NtGi2L-Gs-CtGq)/β1/γ2
36.84Consensush2_on_gpOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
36.67Single8XVEBQ30208XVE-ETB-BQ3020-chim(Gs-CtGq)/β1/γ2
36.67Consensusgi_peptideOrthosteric Ligandgi_cck gi_apelin gi_compl-pept gi_endothelin gi_formylpeptide gi_galanin gi_ghrelin gi_npy gi_neurotensin gi_opioid gi_orexin gi_relaxin gi_somatostatin
36.36Single2VT4Cyanopindolol2VT4-β1-Cyanopindolol
36.36Single2Y02Carmoterol2Y02-β1-Carmoterol
36.36Single2YCYCyanopindolol2YCY-β1-Cyanopindolol
36.36Single3NYAS-Alprenolol3NYA-β2-S-Alprenolol
36.36Single4DAJTiotropium4DAJ-M3-Tiotropium
36.36Single4EA3PubChem 102965614EA3-NOP-PubChem 10296561
36.36Single4MQSIperoxo4MQS-M2-Iperoxo
36.36Single4U14Tiotropium4U14-M3-Tiotropium
36.36Single4U16N-Methyl-Scopolamine4U16-M3-N-Methyl-Scopolamine
36.36Single5TGZAM65385TGZ-CB1-AM6538
36.36Single5YC8N-Methyl-Scopolamine5YC8-M2-N-Methyl-Scopolamine
36.36Single5ZK8N-Methyl-Scopolamine5ZK8-M2-N-Methyl-Scopolamine
36.36Single5ZKCN-Methyl-Scopolamine5ZKC-M2-N-Methyl-Scopolamine
36.36Single6H7MSalbutamol6H7M-β1-Salbutamol
36.36Single6K42Dexmedetomidine6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
36.36Single6PRZS-Alprenolol6PRZ-β2-S-Alprenolol
36.36Single6WHADB139486WHA-5-HT2A-DB13948-chim(NtGi2L-Gs-CtGq)/β1/γ2
36.36Single7BTSL-Epinephrine7BTS-β1-L-Epinephrine
36.36Single7BU6L-Norepinephrine7BU6-β1-L-Norepinephrine
36.36Single7E32Serotonin7E32-5-HT1D-Serotonin-Gi1/β1/γ2
36.36Single7LJCSKF-812977LJC-D1-SKF-81297-Mevidalen-Gs/β1/γ2
36.36Single7M3JNPS-2143; PO47M3J-CaS-NPS-2143; PO4
36.36Single7SCGFH2107SCG-μ-FH210-Gi1/β1/γ2
36.36Single7SQOTAK-9257SQO-OX2-TAK-925-Gi1/β1/γ2
36.36Single7T2GMitragynine Pseudoindoxyl7T2G-μ-Mitragynine Pseudoindoxyl-Gi1/β1/γ2
36.36Single7T6VfMLFII7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2
36.36Single7TRPIperoxo7TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
36.36Single7UL4Alvimopan7UL4-μ-Alvimopan
36.36Single7VIFS-FTY720-P7VIF-S1P1-S-FTY720-P-Gi1/β1/γ2
36.36Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
36.36Single8CU6LJ-45178CU6-A2A-LJ-4517
36.36Single8CU7LJ-45178CU7-A2A-LJ-4517-Na
36.36Single8EFQDamgo8EFQ-μ-Damgo-Gi1/β1/γ2
36.36Single8GE3Constrained Epinephrine8GE3-β2-Constrained Epinephrine-Gs/β1/γ2
36.36Single8GECConstrained Epinephrine8GEC-β2-Constrained Epinephrine-Gs/β1/γ2
36.36Single8GEEConstrained Epinephrine8GEE-β2-Constrained Epinephrine-Gs/β1/γ2
36.36Single8GFVConstrained Epinephrine8GFV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.36Single8GFWConstrained Epinephrine8GFW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.36Single8GFXConstrained Epinephrine8GFX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.36Single8GFZConstrained Epinephrine8GFZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.36Single8GG0Constrained Epinephrine8GG0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.36Single8GG1Constrained Epinephrine8GG1-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.36Single8GG3Constrained Epinephrine8GG3-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.36Single8GG4Constrained Epinephrine8GG4-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.36Single8GG6Constrained Epinephrine8GG6-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.36Single8GG9Constrained Epinephrine8GG9-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.36Single8GGIConstrained Epinephrine8GGI-β2-Constrained Epinephrine
36.36Single8GGJConstrained Epinephrine8GGJ-β2-Constrained Epinephrine
36.36Single8GGKConstrained Epinephrine8GGK-β2-Constrained Epinephrine
36.36Single8GGNConstrained Epinephrine8GGN-β2-Constrained Epinephrine
36.36Single8GGOConstrained Epinephrine8GGO-β2-Constrained Epinephrine
36.36Single8GGUConstrained Epinephrine8GGU-β2-Constrained Epinephrine
36.36Single8IRTRotigotine8IRT-D3-Rotigotine-Gi1/β1/γ2
36.36Single8JJOAlprenolol8JJO-β2-Alprenolol
36.36Single8JLJT1AM8JLJ-TA1-T1AM-chim(NtGi1-Gs)/β1/γ2
36.36Single8PJKST1718PJK-5-HT1A-ST171-Gi1/β1/γ1
36.36Single8UGYMianserin8UGY-5-HT1E-Mianserin-Gi1/β1/γ1
36.36Single8UNQConstrained Epinephrine8UNQ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.36Single8UNVConstrained Epinephrine8UNV-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.36Single8UNYConstrained Epinephrine8UNY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.36Single8UNZConstrained Epinephrine8UNZ-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.36Single8UO2Constrained Epinephrine8UO2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
36.36Single8W8ARO52563908W8A-TA1-RO5256390-chim(NtGi1L-Gs)/β1/γ2
36.36Single8X63Mepyramine8X63-H1-Mepyramine
36.36Single8X64Desloratadine8X64-H1-Desloratadine
36.36Single9EPP11,20-Ethanoretinal9EPP-Rhodopsin-11,20-Ethanoretinal-chim(Gi1-CtGq)/β1/γ2
36.36Single9H37A1IR09H37-A2A-A1IR0-Na
36.36Single9JEAAtropine9JEA-M1-Atropine
36.36Single9PQD(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole9PQD-α2a-(6m)-1-methyl-6-(1,2,5,6-tetrahydropyridin-3-yl)-1h-indole
36.36Consensus5ht1d_onOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
36.36Consensus5ht1d_on_gpOrthosteric Ligand7E32-5-HT1D-Serotonin-Gi1/β1/γ2
36.36Consensusadenosine_on_gpOrthosteric Liganda1_on_gp a2_on_gp a3_on_gp
36.36Consensusadrenergic_onOrthosteric Ligandalpha_on beta_on
36.36Consensusalicarboxylic_on_gpOrthosteric Ligandsuccinate_on_gp hca_on_gp
36.36Consensusalpha2_onOrthosteric Ligandalpha2b_on
36.36Consensusalpha2_on_gpOrthosteric Ligandalpha2b_on_gp
36.36Consensusalpha2b_onOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
36.36Consensusalpha2b_on_gpOrthosteric Ligand6K42-α2b-Dexmedetomidine-Gi1/β1/γ2
36.36Consensusdopamine_onOrthosteric Ligandd2_on d1_on d3_on d4_on d5_on
36.36Consensusdopamine_on_gpOrthosteric Ligandd2_on_gp d1_on_gp d3_on_gp d4_on_gp d5_on_gp
36.36Consensusgi_alicarboxylicOrthosteric Ligandgi_hca gi_succinate
36.36Consensusgi_orexinOrthosteric Ligand7SQO-OX2-TAK-925-Gi1/β1/γ2
36.36Consensushistamine_offOrthosteric Ligandh1_off
36.36Consensuslipid_offOrthosteric Ligandcannabinoid_off paf_off lpl_off prostanoid_off leukotriene_off
36.00Single5UNGPubChem 157800525UNG-AT2-PubChem 15780052
36.00Single6H7LDobutamine6H7L-β1-Dobutamine
36.00Single6IBLArformoterol6IBL-β1-Arformoterol
36.00Single6TKOArformoterol6TKO-β1-Arformoterol-Arrestin2
36.00Single7JVRBromoergocryptine7JVR-D2-Bromoergocryptine-Gi1/β1/γ2
36.00Single7SK7CCX6627SK7-ACKR3-CXCL12-CCX662
36.00Single7SK8CCX6627SK8-ACKR3-CXCL12-CCX662
36.00Single7WVVfMLFII7WVV-FPR2-ALX-fMLFII-Gi2/β1/γ2
36.00Single7XK2MK68927XK2-HCA2-MK6892-Gi1/β1/γ2
36.00Single7XZ6APD6687XZ6-GPR119-APD668-Gs/β1/γ2
36.00Single8I95EP548I95-C3aB-EP54-Go/β1/γ2
36.00Single8IJDMK68928IJD-HCA2-MK6892-Gi1/β1/γ2
36.00Single8IYSTUG-8918IYS-FFA4-TUG-891-GDP-chim(NtGi1L-Gq)/β1/γ2
36.00Single8J19LY2378J19-GPR84-LY237-Gi1/β1/γ2
36.00Single8T3OTUG-8918T3O-FFA4-TUG-891-chim(NtGi2L-Gs-CtGq)/β1/γ2
36.00Single8XVJMacitentan8XVJ-ETA-Macitentan
36.00Single8ZWGJR14a8ZWG-C3aB-JR14a-Gi1/β1/γ2
36.00Single9AS02-bromo-LSD9AS0-5-HT2A-2-bromo-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
36.00Single9DYEBuspirone9DYE-5-HT1A-Buspirone-Go/β1/γ2
36.00Consensusbeta1_onOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
36.00Consensusbeta1_on_gpOrthosteric Ligand8DCR-β1-Dobutamine-Gs/β1/γ2 7S0F-β1-Isoprenaline-Gi1/β1/γ2
36.00Consensusnucleotide_on_gpOrthosteric Ligandadenosine_on_gp p2y_on_gp
36.00Consensusorexin_on_gpOrthosteric Ligandox2_on_gp
35.71Single5WF5UK-4320975WF5-A2A-UK-432097
35.71Single6W25SHU91196W25-MC4-SHU9119-Ca
35.71Single7T6TfMLFII7T6T-FPR1-ALX-fMLFII-Gi1/β1/γ2
35.71Single8XIRPasireotide8XIR-SST3-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
35.71Single9U4WGonadoliberin-19U4W-GnRH1-Gonadoliberin-1-chim(NtGi1L-Gs-CtGq)/β1/γ2
35.71Consensusgi_somatostatinOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
35.71Consensuspeptide_offonOrthosteric Ligandpeptide_off peptide_on
35.71Consensussomatostatin_onOrthosteric Ligandsst2_on sst4_on sst5_on
35.71Consensussomatostatin_on_gpOrthosteric Ligandsst2_on_gp sst4_on_gp sst5_on_gp
35.48Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
35.48Consensusgq_peptideOrthosteric Ligandgq_cck gq_kisspeptin gq_bradykinin gq_bombesin gq_angiotensin
35.48Consensuspeptide_onOrthosteric Ligandcck_on angiotensin_on apelin_on bombesin_on bradykinin_on compl-peptide_on endothelin_on formylpeptide_on galanin_on ghrelin_on kisspeptin_on melanocortin_on motilin_on neuromedin-u_on npy_on neurotensin_on opioid_on orexin_on relaxin_on somatostatin_on tachykinin_on trh_on vasop-oxy_on
35.48Consensuspeptide_on_gpOrthosteric Ligandcck_on_gp angiotensin_on_gp apelin_on_gp bombesin_on_gp bradykinin_on_gp compl-peptide_on_gp endothelin_on_gp formylpeptide_on_gp galanin_on_gp ghrelin_on_gp kisspeptin_on_gp melanocortin_on_gp motilin_on_gp neuromedin-u_on_gp npy_on_gp neurotensin_on_gp opioid_on_gp orexin_on_gp relaxin_on_gp somatostatin_on_gp tachykinin_on_gp trh_on_gp vasop-oxy_on_gp
35.29Consensusgs_peptideOrthosteric Ligandgs_cck gs_melanocortin gs_vasop-oxy
35.00Single6TP4ACT-4622066TP4-OX1-ACT-462206
35.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
35.00Single7XT9Serotonin7XT9-5-HT4-Serotonin-Gs/β1/γ2
35.00Single7XTBSerotonin7XTB-5-HT6-Serotonin-Gs/β1/γ2
35.00Single7YFCHistamine7YFC-H4-Histamine-chim(NtGi1-Gs-CtGq)/β1/γ2
35.00Single8EF6Morphine8EF6-μ-Morphine-Gi1/β1/γ2
35.00Single8JLOUlotaront8JLO-TA1-Ulotaront-Gs/β1/γ2
35.00Single8W89PEA8W89-TA1-PEA-chim(NtGi1L-Gs)/β1/γ2
35.00Single8YN4Histamine8YN4-H2-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
35.00Single9IJEEpinephrine9IJE-β3-Epinephrine-chim(NtGi1-Gs)/β1/γ2
35.00Single9IXJHistamine9IXJ-H2-Histamine-Gs/β1/γ2
34.78Single5NM2ZM-2413855NM2-A2A-ZM-241385-Na
34.78Single5WIUNemonapride5WIU-D4-Nemonapride
34.78Single5WIVNemonapride5WIV-D4-Nemonapride-Na
34.78Single6HLPNetupitant6HLP-NK1-Netupitant
34.78Single6ME62-Phenylmelatonin6ME6-MT2-2-Phenylmelatonin
34.78Single7TRKIperoxo7TRK-M4-Iperoxo-Gi1/β1/γ2
34.78Single7VUHJNJ-635330547VUH-GPR139-JNJ-63533054-chim(Gs-CtGq)/β1/γ2
34.78Single7XKAConstrained Epinephrine7XKA-β2-Constrained Epinephrine
34.78Single7YU3ONO-07405567YU3-LPA1-ONO-0740556-Gi1/β1/γ2
34.78Single7YU6ONO-07405567YU6-LPA1-ONO-0740556-Gi1/β1/γ2
34.78Single8E9ZIperoxo8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2
34.78Single8GDZConstrained Epinephrine8GDZ-β2-Constrained Epinephrine-Gs/β1/γ2
34.78Single8GEBConstrained Epinephrine8GEB-β2-Constrained Epinephrine-Gs/β1/γ2
34.78Single8GEGConstrained Epinephrine8GEG-β2-Constrained Epinephrine-Gs/β1/γ2
34.78Single8GFYConstrained Epinephrine8GFY-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
34.78Single8GG2Constrained Epinephrine8GG2-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
34.78Single8GGBConstrained Epinephrine8GGB-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
34.78Single8TF5Oleic acid8TF5-GPR6-Oleic acid
34.78Single8UNNConstrained Epinephrine8UNN-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
34.78Single8UNPConstrained Epinephrine8UNP-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
34.78Single8WGBVU01550418WGB-mGlu4; mGlu2-Glutammate-VU0155041-Gi3/β1/γ2
34.78Single8XYKVUF106618XYK-CXCR3-VUF10661-Go/β1/γ2
34.78Single9ARYSerotonin9ARY-5-HT2A-Serotonin-chim(NtGi1-Gs-CtGq)/β1/γ2
34.78Single9ARZ2-bromo-LSD9ARZ-5-HT2A-2-bromo-LSD
34.78Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
34.78Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
34.78Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
34.78Single9ERXD9-THC analog9ERX-CB1-D9-THC analog-Gi1/β1/γ2
34.78Single9HAPTolvaptan9HAP-V2-Tolvaptan
34.78Consensus5ht1_onOrthosteric Ligand5ht1a_on 5ht1d_on 5ht1e_on 5ht1f_on
34.78Consensus5ht1_on_gpOrthosteric Ligand5ht1a_on_gp 5ht1d_on_gp 5ht1e_on_gp 5ht1f_on_gp
34.78Consensus5ht1e_on_gpOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
34.78Consensus5ht2_offOrthosteric Ligand5ht2a_off 5ht2b_off 5ht2c_off
34.78Consensusadenosine_offOrthosteric Liganda1_off a2_off
34.78Consensusm2_offOrthosteric Ligand5ZKC-M2-N-Methyl-Scopolamine 5ZK3-M2-3-quinuclidinyl-benzilate 5ZKB-M2-AF-DX 384
34.78Consensusm3_onOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
34.78Consensusm3_on_gpOrthosteric Ligand8E9Z-M3-Iperoxo-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9W-M3-2-Deoxycytidine-chim(NtGi2L-Gs-CtGq)/β1/γ2 8E9Y-M3-Clozapine-N-oxide-chim(NtGi2L-Gs-CtGq)/β1/γ2
34.62Single5WF6UK-4320975WF6-A2A-UK-432097
34.62Single6XBJCholesterol6XBJ-SMO-Cholesterol-Gi1/β1/γ2
34.62Single7XBXCX3CL17XBX-CX3CR1-CX3CL1-Gi1/β1/γ2
34.62Single7Y1FDynorphin7Y1F-κ-Dynorphin-Gi1/β1/γ2
34.62Single8QJ2pN1628QJ2-MC4-pN162-Gs
34.62Single9IPVJR14a9IPV-C3aB-JR14a-Gi1/β1/γ2
34.62Single9IZASCH9002719IZA-HCA2-SCH900271-Gi1/β1/γ2
34.62Single9JF4PD1683689JF4-BB1-PD168368
34.62Consensuscxcr3_onOrthosteric Ligand8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2
34.62Consensuskiss1_onOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
34.62Consensuskisspeptin_onOrthosteric Ligandkiss1_on
34.48Single7F4HAfamelanotide7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2
34.48Single7W40Bombesin7W40-BB2-Bombesin-chim(NtGi1L-Gq)/β1/γ2
34.48Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
34.48Single8J6IMK68928J6I-HCA2-MK6892-Gi1/β1/γ2
34.48Single8XWQEndothelin-18XWQ-ETB-Endothelin-1-Gi1/β1/γ2
34.48Single9BKKCholecystokinin-89BKK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
34.48Consensuspeptide_offon_gpOrthosteric Ligandpeptide_on_gp peptide_off
34.38Single6IGLIRL16206IGL-ETB-IRL1620
34.38Single8Y52BA18Y52-BB3-BA1-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single3PDSHydroxybenzylisoproterenol3PDS-β2-Hydroxybenzylisoproterenol
33.33Single3V2WPubChem 518926453V2W-S1P1-PubChem 51892645
33.33Single3VGAZM-2413853VGA-A2A-ZM-241385-Antibody
33.33Single4IB4Ergotamine4IB4-5-HT2B-Ergotamine
33.33Single4LDLHydroxybenzylisoproterenol4LDL-β2-Hydroxybenzylisoproterenol
33.33Single4S0VSuvorexant4S0V-OX2-Suvorexant
33.33Single5UNFPubChem 157800525UNF-AT2-PubChem 15780052
33.33Single5V54Methiothepin5V54-5-HT1B-Methiothepin
33.33Single5WS3EMPA5WS3-OX2-EMPA
33.33Single6AKYMaraviroc6AKY-CCR5-Maraviroc
33.33Single6D9HAdenosine6D9H-A1-Adenosine-Gi2/β1/γ2
33.33Single6DS0Ly2660976DS0-5-HT2B-Ly266097
33.33Single6KO5PubChem 574000026KO5-Ghrelin-PubChem 57400002
33.33Single6KUYPubChem 1457046436KUY-α2a-PubChem 145704643
33.33Single6NWEOctyl-Beta-D-Glucopyranoside6NWE-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
33.33Single6TODEMPA6TOD-OX1-EMPA-Na
33.33Single6TPJSuvorexant6TPJ-OX2-Suvorexant
33.33Single7EW1Siponimod7EW1-S1P5-Siponimod-Gi1/β1/γ2
33.33Single7LD4Adenosine7LD4-A1-Adenosine-Gi2/β1/γ2
33.33Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
33.33Single7M3ECa; Ca; Tryptophan; NPS-21437M3E-CaS-Ca; Ca; Tryptophan; NPS-2143
33.33Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
33.33Single7P02Protachykinin-17P02-NK1-Protachykinin-1-chim(NtGi1-Gs)/β1/γ2
33.33Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
33.33Single7T6SPubChem 247763417T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2
33.33Single7T8XAcetylcholine7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
33.33Single7T90Acetylcholine7T90-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
33.33Single7T96Acetylcholine7T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
33.33Single7TD1LPA7TD1-LPA1-LPA-Gi1/β1/γ2
33.33Single7TRQIperoxo7TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
33.33Single7TUYGSK682753A7TUY-GPR183-GSK682753A
33.33Single7VIHCBP-3077VIH-S1P1-CBP-307-Gi1/β1/γ2
33.33Single7WF7S1P7WF7-S1P1-S1P-Gi1/β1/γ2
33.33Single7WKDTRH7WKD-TRH-TRH-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single7WVXHumanin7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2
33.33Single7X2FDopamine7X2F-D1-Dopamine-Mevidalen-Gs/β1/γ2
33.33Single7X5H5-CT7X5H-5-HT5A-5-CT-Gi1/β1/γ2
33.33Single7XRRLemborexant7XRR-OX2-Lemborexant
33.33Single7XT8Serotonin7XT8-5-HT4-Serotonin-Gs/β1/γ2
33.33Single7XTQR3997XTQ-GPBA-R399-Gs/β1/γ2
33.33Single7YMHNorepinephrine7YMH-Alpha1A-Norepinephrine-chim(Gs-CtGq)
33.33Single7YU5ONO-07405567YU5-LPA1-ONO-0740556-Gi1/β1/γ2
33.33Single8DU3PubChem 1055260648DU3-A2A-PubChem 105526064
33.33Single8EA0Iperoxo8EA0-M3-Iperoxo
33.33Single8GGAConstrained Epinephrine8GGA-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8GGRConstrained Epinephrine8GGR-β2-Constrained Epinephrine
33.33Single8GGZConstrained Epinephrine8GGZ-β2-Constrained Epinephrine
33.33Single8GH0Constrained Epinephrine8GH0-β2-Constrained Epinephrine
33.33Single8HDPAdenosine8HDP-A2B-Adenosine-Gs/β1/γ2
33.33Single8HOCImetit8HOC-H4-Imetit-Gi1/β1/γ2
33.33Single8HPTC5a anaphylatoxin C-terminal peptide8HPT-C5a1-C5a anaphylatoxin C-terminal peptide-Go/β1/γ2
33.33Single8I9LC3a anaphylatoxin8I9L-C3aB-C3a anaphylatoxin-Go/β1/γ2
33.33Single8ID6Oleic acid8ID6-FFA4-Oleic acid-Gi1/β1/γ2
33.33Single8IEBA1LYA8IEB-GPR156-A1LYA
33.33Single8IHBGSK2560738IHB-HCA2-GSK256073-Gi1/β1/γ2
33.33Single8IODPG-9018IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
33.33Single8IYHMK68928IYH-HCA2-MK6892-Go/β1/γ2
33.33Single8J6RMK68928J6R-HCA2-MK6892-Gi1/β1/γ2
33.33Single8JLPRalmitaront8JLP-TA1-Ralmitaront-Gs/β1/γ2
33.33Single8JSRAnamorelin8JSR-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single8JXWVUF68848JXW-H4-VUF6884-Gi1/β1/γ2
33.33Single8TZQL-Dopamine8TZQ-D2-L-Dopamine-Go/β1/γ2
33.33Single8UGWPubChem 30865998UGW-A2A-PubChem 3086599
33.33Single8UNSConstrained Epinephrine8UNS-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8UNTConstrained Epinephrine8UNT-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8UNXConstrained Epinephrine8UNX-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
33.33Single8WC3SEP-3638568WC3-TA1-SEP-363856-chim(NtGi1-Gs)/β1/γ2
33.33Single8WKYPG-9348WKY-MC4-PG-934
33.33Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
33.33Single8XQEApelin-138XQE-Apelin-Apelin-13-Gi1/β1/γ2
33.33Single8YH6Namodenoson8YH6-A3A-Namodenoson-Gi1/β1/γ2
33.33Single8YNAImmepip8YNA-H4-Immepip-Gi1/β1/γ2
33.33Single8YUTAmthamine8YUT-H2-Amthamine-Gs/β1/γ2
33.33Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
33.33Single8ZJDKisspeptin-108ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
33.33Single8ZJETAK-4488ZJE-Kiss1-TAK-448-chim(NtGi1-Gq)/β1/γ1
33.33Single8ZRTET-18ZRT-ETB-ET-1
33.33Single9AS9RS130-1809AS9-5-HT2A-RS130-180
33.33Single9ASARS130-1809ASA-5-HT2A-RS130-180-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single9AYFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AYF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi1/β1/γ2
33.33Single9BKJCholecystokinin-89BKJ-CCKA-Cholecystokinin-8-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single9BUYLM1899BUY-β2-LM189-Gi1/β1/γ2
33.33Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
33.33Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
33.33Single9EEAAdenosine9EEA-A2A-Adenosine-Gs/β1/γ2
33.33Single9H2XA1IR19H2X-A2A-A1IR1-Na
33.33Single9IK9SST analogue9IK9-SST1-SST analogue-Gi1/β1/γ2
33.33Single9IZGNKP9IZG-LPA1-NKP-chim(NtGi1-Gs-CtGq)/β1/γ2
33.33Single9JFYhNPSF9JFY-NPFF2-hNPSF-Gi1/β1/γ2
33.33Single9JMCDS-3801b9JMC-Motilin-DS-3801b-chim(Gs-CtGq)/β1/γ2
33.33Single9KPESA09KPE-TAS2R16-SA0-Gi1/β1/γ2
33.33Single9LRBHistamine9LRB-H1-Histamine-Gs/β1/γ2
33.33Consensus5ht1_offOrthosteric Ligand5ht1b_off
33.33Consensus5ht1b_offOrthosteric Ligand5V54-5-HT1B-Methiothepin
33.33Consensus5ht1e_onOrthosteric Ligand7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1
33.33Consensus5ht_offOrthosteric Ligand5ht2_off 5ht1_off
33.33Consensus5ht_onOrthosteric Ligand5ht1_on 5ht2_on 5ht4_on 5ht5_on 5ht6_on 5ht7_on
33.33Consensusa1_onOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
33.33Consensusa1_on_gpOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2
33.33Consensusalpha2_offOrthosteric Ligandalpha2c_off
33.33Consensusgi_5htOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7UM7-5-HT5A-Methylergometrine-chim(NtGi1-Go)/β1/γ2 8UGY-5-HT1E-Mianserin-Gi1/β1/γ1 8W8B-5-HT1A-SEP-363856-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E32-5-HT1D-Serotonin-Gi1/β1/γ2 7XTA-5-HT4-Serotonin-Gi1/β1/γ2 8UH3-5-HT1E-Setiptiline-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 7X5H-5-HT5A-5-CT-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 7E33-5-HT1E-BRL-54443-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 7EXD-5-HT1F-Lasmiditan-Gi1/β1/γ2 7UM6-5-HT5A-Lisuride-chim(NtGi1-Go)/β1/γ2
33.33Consensusgi_dopamineOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 7CMV-D3-PD128907-Gi1/β1/γ2 7CMU-D3-Pramipexole-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2 8IRT-D3-Rotigotine-Gi1/β1/γ2
33.33Consensusgi_lpaOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
33.33Consensusgq_kisspeptinOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
33.33Consensusgs_5htOrthosteric Ligand7XTC-5-HT7-5-CT-Gs/β1/γ2 7XTB-5-HT6-Serotonin-Gs/β1/γ2 8JLZ-5-HT6-ST1936-Gs/β1/γ2 7XT8-5-HT4-Serotonin-Gs/β1/γ2
33.33Consensusgs_adrenergicOrthosteric Ligand7DHI-β2-Salbutamol-Gs/β1/γ2 7XJI-β3-Solabegron-Gs/β1/γ2 7JJO-β1-Isoprenaline-Gs/β1/γ2 6NI3-β2-BI167107-Gs/β1/γ2 8DCR-β1-Dobutamine-Gs/β1/γ2 7XJH-β3-Isoproterenol-Gs/β1/γ2 7DH5-β3-Mirabegron-Gs/β1/γ2
33.33Consensush4_on_gpOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
33.33Consensushistamine_onOrthosteric Ligandh1_on h2_on h3_on h4_on
33.33Consensushistamine_on_gpOrthosteric Ligandh1_on_gp h2_on_gp h3_on_gp h4_on_gp
33.33Consensuskiss1_on_gpOrthosteric Ligand8ZJD-Kiss1-Kisspeptin-10-chim(NtGi1-Gq)/β1/γ1
33.33Consensuskisspeptin_on_gpOrthosteric Ligandkiss1_on_gp
33.33Consensuslpa_onOrthosteric Ligandlpa1_on
33.33Consensuslpa_on_gpOrthosteric Ligandlpa1_on_gp
33.33Consensusm2_onOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
33.33Consensusm2_on_gpOrthosteric Ligand7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2
33.33Consensusox1_offOrthosteric Ligand6TP6-OX1-Filorexant 6TP4-OX1-ACT-462206 6V9S-OX1-GTPL11403 6TOT-OX1-Lemborexant 6TP3-OX1-Nemorexant 6TQ6-OX1-PubChem 145714283 6TQ9-OX1-SB-408124 4ZJC-OX1-SB-674042 4ZJ8-OX1-Suvorexant 6TOD-OX1-EMPA-Na 6TOS-OX1-GSK1059865-Na 6TQ4-OX1-PubChem 16046844-Na
33.33Consensuss1p1_offOrthosteric Ligand3V2W-S1P1-PubChem 51892645
33.33Consensuss1p5_onOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
33.33Consensuss1p5_on_gpOrthosteric Ligand7EW1-S1P5-Siponimod-Gi1/β1/γ2
33.33Consensussst5_onOrthosteric Ligand8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2 8X8N-SST5-Octreotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
33.33Consensustachykinin_offOrthosteric Ligandnk1_off
32.35Single8HBDIRL16208HBD-ETB-IRL1620-Gi1/β1/γ2
32.35Consensusmelanocortin_onOrthosteric Ligandmc1_on mc4_on mc2_on mc3_on mc5_on
32.35Consensusmelanocortin_on_gpOrthosteric Ligandmc1_on_gp mc4_on_gp mc2_on_gp mc3_on_gp mc5_on_gp
32.26Single7QBIAlpha-factor mating pheromone7QBI-STE2-α-factor mating pheromone
32.26Consensusnpy4_onOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
32.26Consensusnpy4_on_gpOrthosteric Ligand7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
32.14Single7EZKCholecystokinin-87EZK-CCKA-Cholecystokinin-8-chim(NtGi1-Gs)/β1/γ2
32.14Single8F7QBeta-Endorphin8F7Q-μ-β-Endorphin-Gi1/β1/γ2
32.14Single8XYDPlatelet Activating Factor8XYD-PAF-Platelet Activating Factor-Gi1/β1/γ2
32.14Single9IK8SST analogue9IK8-SST1-SST analogue-Gi1/β1/γ2
32.14Consensusformylpeptide_on_gpOrthosteric Ligandfpr2-alx_on_gp fpr1-alx_on_gp
32.14Consensusghrelin_onOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
32.14Consensusghrelin_on_gpOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
32.14Consensusgi_ghrelinOrthosteric Ligand7NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2 7NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
32.14Consensusgq_class-aOrthosteric Ligandgq_peptide gq_amine gq_nucleotide
32.14Consensussst4_onOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
32.14Consensussst4_on_gpOrthosteric Ligand7XMS-SST4-Somatostatin-14-Gi1/β1/γ2 7XMT-SST4-J-2156-Gi1/β1/γ2
32.00Single6A93Risperidone6A93-5-HT2A-Risperidone
32.00Single6DRYMethylergonovine6DRY-5-HT2B-Methylergonovine
32.00Single6MXTSalmeterol6MXT-β2-Salmeterol
32.00Single6VMSBromoergocryptine6VMS-D2-Bromoergocryptine-Gi1/β1/γ2
32.00Single6ZG4HTL00099366ZG4-M1-HTL0009936
32.00Single7BZ2Arformoterol7BZ2-β2-Arformoterol-Gs/β1/γ2
32.00Single7K15MKD0467K15-BLT1-MKD046-Na
32.00Single7SUSPubChem 1227019087SUS-Apelin-PubChem 122701908
32.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
32.00Single7W0LPubChem 1227019087W0L-Apelin-PubChem 122701908-Gi1/β1/γ2
32.00Single8IYWGSK2560738IYW-HCA2-GSK256073-Go/β1/γ2
32.00Single8JD3JNJ-404118138JD3-mGlu2; mGlu3-Glutamate-JNJ-40411813-Gi1/β1/γ2
32.00Single8JZ7MK68928JZ7-HCA2-MK6892-Gi1/β1/γ2
32.00Single8T3QDocosa-4,7,10,13,16,19-Hexaenoic acid8T3Q-FFA4-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
32.00Consensus5ht1a_onOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
32.00Consensus5ht1a_on_gpOrthosteric Ligand8FYT-5-HT1A-LSD-Gi1/β1/γ1 8FYX-5-HT1A-Buspirone-Gi1/β1/γ1 8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2 8JT6-5-HT1A-(R)-IHCH-7179-Gi1/β1/γ2 7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2 7E2Z-5-HT1A-Aripiprazole-Gi1/β1/γ2 8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1 8FYE-5-HT1A-4-F,5-MeO-PyrT-Gi1/β1/γ1 8FYL-5-HT1A-Vilazodone-Gi1/β1/γ1
32.00Consensusd2_on_gpOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
31.82Single1F8811-cis-Retinal1F88-Rhodopsin-11-cis-Retinal
31.82Single3RZECidoxepin3RZE-H1-Cidoxepin
31.82Single3UZC4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol3UZC-A2A-4-(3-amino-5-phenyl-1,2,4-triazin-6-yl)-2-chlorophenol
31.82Single4MQTIperoxo4MQT-M2-Iperoxo-LY2119620
31.82Single5IU7Q274563465IU7-A2A-Q27456346-Na
31.82Single5JTBZM-2413855JTB-A2A-ZM-241385
31.82Single5TE3Octyl-Beta-D-Glucopyranoside5TE3-Rhodopsin-Octyl-β-D-Glucopyranoside
31.82Single6A94Zotepine6A94-5-HT2A-Zotepine
31.82Single6AQFZM-2413856AQF-A2A-ZM-241385
31.82Single6IQLL7458706IQL-D4-L745870
31.82Single6KUXRS-799486KUX-α2a-RS-79948
31.82Single6PELCitronellol6PEL-Rhodopsin-Citronellol-Gt(CT)
31.82Single6TPKRetosiban6TPK-OT-Retosiban
31.82Single6WH4Methiothepin6WH4-5-HT2A-Methiothepin
31.82Single6ZDRHMS1413f126ZDR-A2A-HMS1413f12-Na
31.82Single7DHISalbutamol7DHI-β2-Salbutamol-Gs/β1/γ2
31.82Single7F1ZDopamine7F1Z-D1-Dopamine-GDP-Gs/β1/γ2
31.82Single7F24Dopamine7F24-D1-Dopamine-GDP-Gs/β1/γ2
31.82Single7F61PF-036547467F61-H3-PF-03654746
31.82Single7T94Acetylcholine7T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
31.82Single7TRSAcetylcholine7TRS-M4-Acetylcholine-Gi1/β1/γ2
31.82Single7VUGJNJ-635330547VUG-GPR139-JNJ-63533054-Gi1/β1/γ2
31.82Single7WC9PubChem 1624213647WC9-5-HT2A-PubChem 162421364
31.82Single7WVUfMLF7WVU-FPR1-ALX-fMLF-Gi1/β1/γ2
31.82Single8FCZ11-cis-Retinal8FCZ-Rhodopsin-11-cis-Retinal
31.82Single8GE1Constrained Epinephrine8GE1-β2-Constrained Epinephrine-Gs/β1/γ2
31.82Single8GE4Constrained Epinephrine8GE4-β2-Constrained Epinephrine-Gs/β1/γ2
31.82Single8GE6Constrained Epinephrine8GE6-β2-Constrained Epinephrine-Gs/β1/γ2
31.82Single8GE7Constrained Epinephrine8GE7-β2-Constrained Epinephrine-Gs/β1/γ2
31.82Single8GE8Constrained Epinephrine8GE8-β2-Constrained Epinephrine-Gs/β1/γ2
31.82Single8GEDConstrained Epinephrine8GED-β2-Constrained Epinephrine-Gs/β1/γ2
31.82Single8GEFConstrained Epinephrine8GEF-β2-Constrained Epinephrine-Gs/β1/γ2
31.82Single8GG5Constrained Epinephrine8GG5-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8GGSConstrained Epinephrine8GGS-β2-Constrained Epinephrine
31.82Single8GGTConstrained Epinephrine8GGT-β2-Constrained Epinephrine
31.82Single8GGVConstrained Epinephrine8GGV-β2-Constrained Epinephrine
31.82Single8IHKAcifran8IHK-HCA3-Acifran
31.82Single8JIMMMF8JIM-HCA2-MMF-Gi1/β1/γ2
31.82Single8JLNT1AM8JLN-TA1-T1AM-Gs/β1/γ2
31.82Single8JSPUlotaront8JSP-5-HT1A-Ulotaront-Gi1/β1/γ2
31.82Single8K5CAcipimox8K5C-HCA2-Acipimox
31.82Single8K9LDamgo8K9L-μ-Damgo-BMS-986122-Gi3/β1/γ1
31.82Single8PM2DMCH8PM2-TA7-DMCH-Gs/β1/γ2
31.82Single8RLNLUF58348RLN-A2A-LUF5834
31.82Single8RQQZM-2413858RQQ-A2A-ZM-241385-Na
31.82Single8UHBRO52563908UHB-TA1-RO5256390-Gs/β1/γ2
31.82Single8UNMConstrained Epinephrine8UNM-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8UNWConstrained Epinephrine8UNW-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8UO0Constrained Epinephrine8UO0-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
31.82Single8UO1Constrained Epinephrine8UO1-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
31.82Single8V6UPubChem 1713924568V6U-5-HT2A-PubChem 171392456-chim(NtGi2-Gs-CtGq)/β1/γ2
31.82Single8WPGTryptophan; Cinacalcet; PO4; Ca8WPG-CaS-Tryptophan; Cinacalcet; PO4; Ca
31.82Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.82Single8Y01Retinal8Y01-Opsin1MW-Retinal-Gi1/β1/γ2
31.82Single8Y45ADL58598Y45-δ-ADL5859-Gi2/β1/γ2
31.82Single8YH2Adenosine8YH2-A3A-Adenosine-Gi1/β1/γ2
31.82Single8YKVPubChem 1375531688YKV-Succinate-PubChem 137553168-Gi1/β1/γ2
31.82Single9AS3LSD9AS3-5-HT2A-LSD
31.82Single9AS4LSD9AS4-5-HT2A-LSD-chim(NtGi1-Gs-CtGq)/β1/γ2
31.82Single9AS5Mescaline9AS5-5-HT2A-Mescaline
31.82Single9AS6Mescaline9AS6-5-HT2A-Mescaline-chim(NtGi1-Gs-CtGq)/β1/γ2
31.82Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
31.82Single9ASBCa; Ca; Cyclomethyltryptophan; 9IG; PO49ASB-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
31.82Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
31.82Single9AXFCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO49AXF-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs-CtGq)/β1/γ2
31.82Single9CBLEpinephrine9CBL-α2a-Epinephrine-Gi1/β1/γ2
31.82Single9JKQMETH9JKQ-TA1-METH-Gs/β1/γ2
31.82Single9JMDAzithromycin9JMD-Motilin-Azithromycin-chim(Gs-CtGq)/β1/γ2
31.82Single9KPDSA09KPD-TAS2R16-SA0-chim(Gs-CtGt3)/β1/γ2
31.82Consensus5ht2a_offOrthosteric Ligand6A94-5-HT2A-Zotepine 6A93-5-HT2A-Risperidone 7VOD-5-HT2A-Cariprazine 7WC8-5-HT2A-Lumateperone 8JT8-5-HT2A-(R)-IHCH-7179
31.82Consensusa2_offOrthosteric Liganda2a_off
31.82Consensusa2a_offOrthosteric Ligand3RFM-A2A-Caffeine 8C9W-A2A-Etrumadenant 3UZA-A2A-GTPL9236 8GNG-A2A-Istradefylline 8CU6-A2A-LJ-4517 7PX4-A2A-PSB-2113 7PYR-A2A-PSB-2115 8DU3-A2A-PubChem 105526064 8JWY-A2A-2-118 8PWN-A2A-Theophylline 5IU4-A2A-ZM-241385-Na 5OLZ-A2A-PubChem 135566609-Na 6GT3-A2A-Imaradenant-Na 5OLV-A2A-LUAA41063-Na 5N2R-A2A-PSB-36-Na 5IU7-A2A-Q27456346-Na 5OLH-A2A-Vipadenant-Na 5OLO-A2A-Tozadenant-Na 6ZDR-A2A-HMS1413f12-Na 8GNE-A2A-KW-6356-Na 8JWZ-A2A-AB928-Na 5IU8-A2A-Q27456347-Na 5IUB-A2A-Q27456344-Na 6ZDV-A2A-Chromone 5d-Na 5IUA-A2A-Q27456348-Na 8A2P-A2A-LUAA47070-Na
31.82Consensusadenosine_onOrthosteric Liganda1_on a2_on a3_on
31.82Consensusgi_adenosineOrthosteric Ligand7LD4-A1-Adenosine-Gi2/β1/γ2 8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
31.82Consensushca_onOrthosteric Ligandhca2_on
31.82Consensusnop_offOrthosteric Ligand4EA3-NOP-PubChem 10296561 5DHG-NOP-C-35 5DHH-NOP-SB-612111
31.82Consensusopsins_offOrthosteric Ligandrhodopsin_off
31.82Consensusot_offOrthosteric Ligand6TPK-OT-Retosiban
31.82Consensussensory_offOrthosteric Ligandopsins_off
31.82Consensusvasop-oxy_offOrthosteric Ligandot_off
31.58Single9CHUNoradrenaline9CHU-β2-Noradrenaline
31.58Consensusgs_histamineOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
31.58Consensush2_onOrthosteric Ligand8POK-H2-Histamine-Gs/β1/γ2
31.43Single6LRYSarafotoxin-B6LRY-ETB-Sarafotoxin-B
31.43Consensuscrf_on_gpOrthosteric Ligandcrf2_on_gp crf1_on_gp
31.25Single7F53Alpha-MSH7F53-MC4-α-MSH-Gs/β1/γ2
31.25Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
31.25Single7WVYAmyloid-Beta427WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2
31.25Single7XATSomatostatin-147XAT-SST2-Somatostatin-14-Gi1/β1/γ2
31.25Single7YOONeuropeptide-Y7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
31.25Consensusnpy2_onOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
31.25Consensusnpy2_on_gpOrthosteric Ligand7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
31.03Single7F4DAlpha-MSH7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2
31.03Single7MBXCholecystokinin-87MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
31.03Single7O7F6P4-CCL57O7F-CCR5-6P4-CCL5-Gi1/β1/γ1
31.03Single7RYCOxytocin7RYC-OT-Oxytocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
31.03Single8K6NPro-neuropeptide-Y8K6N-Y2-Pro-neuropeptide-Y-Gi2/β1/γ1
31.03Single8WKZSBL-MC-318WKZ-MC4-SBL-MC-31
31.03Consensusgs_cckOrthosteric Ligand7MBX-CCKA-Cholecystokinin-8-Gs/β1/γ1
30.77Single4NC3Ergotamine4NC3-5-HT2B-Ergotamine
30.77Single5TUDErgotamine5TUD-5-HT2B-Ergotamine
30.77Single6BQGErgotamine6BQG-5-HT2C-Ergotamine
30.77Single6BQHRitanserin6BQH-5-HT2C-Ritanserin
30.77Single7EZCUKA7EZC-A2A-UKA
30.77Single7P00Substance-P7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Single9M54Neuropeptide VF9M54-NPFF2-Neuropeptide VF-Gi1/β1/γ2
30.77Consensus5ht2c_offOrthosteric Ligand6BQH-5-HT2C-Ritanserin
30.77Consensusd2_offOrthosteric Ligand6CM4-D2-Risperidone 6LUQ-D2-Haloperidol 7DFP-D2-Spiperone
30.77Consensusnk1_onOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
30.77Consensusnk1_on_gpOrthosteric Ligand7P00-NK1-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
30.43Single1HZX11-cis-Retinal1HZX-Rhodopsin-11-cis-Retinal
30.43Single2Y01Dobutamine2Y01-β1-Dobutamine
30.43Single3EMLZM-2413853EML-A2A-ZM-241385
30.43Single4EIYZM-2413854EIY-A2A-ZM-241385-Na
30.43Single4J4QOctyl Beta-D-Glucopyranoside4J4Q-Rhodopsin-Octyl β-D-Glucopyranoside-Gt(CT)
30.43Single4QKX35V4QKX-β2-35V
30.43Single4X1HNonyl-Beta-D-Glucopyranoside4X1H-Rhodopsin-Nonyl-β-D-Glucopyranoside-Gt(CT)
30.43Single5DHGC-355DHG-NOP-C-35
30.43Single5DHHSB-6121115DHH-NOP-SB-612111
30.43Single5DSGTiotropium5DSG-M4-Tiotropium
30.43Single5IU8Q274563475IU8-A2A-Q27456347-Na
30.43Single5K2AZM-2413855K2A-A2A-ZM-241385-Na
30.43Single5OLGZM-2413855OLG-A2A-ZM-241385-Na
30.43Single5UIGCmpd-15UIG-A2A-Cmpd-1
30.43Single5VRAZM-2413855VRA-A2A-ZM-241385-Na
30.43Single5ZKPForopafant (SR27417)5ZKP-PAF-Foropafant (SR27417)
30.43Single6DRZMethysergide6DRZ-5-HT2B-Methysergide
30.43Single6PS1Timolol6PS1-β2-Timolol
30.43Single6S0LZM-2413856S0L-A2A-ZM-241385
30.43Single7BU7BI1671077BU7-β1-BI167107
30.43Single7CFMP3957CFM-GPBA-P395-Gs/β1/γ2
30.43Single7DB6Ramelteon7DB6-MT1-Ramelteon-Gi1/β1/γ2
30.43Single7F83PF-051904577F83-Ghrelin-PF-05190457
30.43Single7NA8PubChem 1780247NA8-Ghrelin-PubChem 178024-Gi1/β1/γ2
30.43Single7PYRPSB-21157PYR-A2A-PSB-2115
30.43Single7UM55-CT7UM5-5-HT5A-5-CT-chim(NtGi1-Go)/β1/γ2
30.43Single7VGZRemalteon7VGZ-MT1-Remalteon-Gi1/β1/γ2
30.43Single7VKTLTB47VKT-BLT1-LTB4-Gi1/β1/γ2
30.43Single7YK7DC5910537YK7-RXFP4-DC591053-Gi2/β1/γ2
30.43Single7YU4ONO-07405567YU4-LPA1-ONO-0740556
30.43Single8FY85-MeO-DMT8FY8-5-HT1A-5-MeO-DMT-Gi1/β1/γ1
30.43Single8GE9Constrained Epinephrine8GE9-β2-Constrained Epinephrine-Gs/β1/γ2
30.43Single8GEHConstrained Epinephrine8GEH-β2-Constrained Epinephrine-Gs/β1/γ2
30.43Single8I7VAcipimox8I7V-HCA2-Acipimox-Gi1/β1/γ2
30.43Single8IHJAcifran8IHJ-HCA3-Acifran-Gi1/β1/γ2
30.43Single8J6PNiacin8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
30.43Single8JIINiacin8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
30.43Single8UNRConstrained Epinephrine8UNR-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.43Single8UNUConstrained Epinephrine8UNU-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
30.43Single8UWLLisuride8UWL-5-HT2A-Lisuride-chim(NtGi2-Gs-CtGq)/β1/γ2
30.43Single8WC7ZH86678WC7-TA1-ZH8667-chim(NtGi1-Gs)/β1/γ2
30.43Single8X17Namodenoson8X17-A3A-Namodenoson-Gi1/β1/γ2
30.43Single8YN8Proxyfan8YN8-H3-Proxyfan-Go/β1/γ2
30.43Single9AS1DMT9AS1-5-HT2A-DMT
30.43Single9AVGCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVG-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-chim(NtGi1-Gs)/β1/γ2
30.43Single9KFJPubChem 1383196749KFJ-RXFP3-PubChem 138319674-Gi2/β1/γ2
30.43Consensus5ht2b_offOrthosteric Ligand6DRZ-5-HT2B-Methysergide
30.43Consensusa3_onOrthosteric Liganda3a_on
30.43Consensusblt1_onOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
30.43Consensusblt1_on_gpOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
30.43Consensusblt_onOrthosteric Ligandblt1_on
30.43Consensusblt_on_gpOrthosteric Ligandblt1_on_gp
30.43Consensusd5_onOrthosteric Ligand8IRV-D5-Rotigotine-chim(NtGi1-Gs)/β1/γ2
30.43Consensusgi_hcaOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
30.43Consensusgi_histamineOrthosteric Ligand8JXX-H4-Clobenpropit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8YUU-H3-Histamine-Gi1/β1/γ1 8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2
30.43Consensusgi_leukotrieneOrthosteric Ligand7VKT-BLT1-LTB4-Gi1/β1/γ2
30.43Consensusgq_amineOrthosteric Ligandgq_muscarinic gq_histamine
30.43Consensushca2_onOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2
30.43Consensushca2_on_gpOrthosteric Ligand8J6R-HCA2-MK6892-Gi1/β1/γ2 8IHI-HCA2-Acifran-Gi1/β1/γ2 8IHH-HCA2-LUF6283-Gi1/β1/γ2 8I7V-HCA2-Acipimox-Gi1/β1/γ2 8JIM-HCA2-MMF-Gi1/β1/γ2 8I7W-HCA2-GSK256073-Gi1/β1/γ2
30.43Consensushca_on_gpOrthosteric Ligandhca2_on_gp
30.43Consensusleukotriene_onOrthosteric Ligandblt_on
30.43Consensusleukotriene_on_gpOrthosteric Ligandblt_on_gp
30.43Consensusm4_offOrthosteric Ligand5DSG-M4-Tiotropium
30.43Consensusmuscarinic_onOrthosteric Ligandm2_on m3_on m4_on m1_on
30.43Consensusmuscarinic_on_gpOrthosteric Ligandm2_on_gp m3_on_gp m4_on_gp m1_on_gp
30.30Single7QBCAlpha-factor mating pheromone7QBC-STE2-α-factor mating pheromone
30.30Single7TS0Urocortin7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
30.30Single8WWNMCH8WWN-MCH1-MCH-Gi1/β1/γ2
30.30Consensusgs_melanocortinOrthosteric Ligand7F4H-MC1-Afamelanotide-chim(NtGi1-Gs)/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F4D-MC1-α-MSH-chim(NtGi1-Gs)/β1/γ2 8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2 8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1 8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2 7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F4I-MC1-SHU9119-chim(NtGi1-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2
30.00Single2J4Y11-cis-Retinal2J4Y-Rhodopsin-11-cis-Retinal
30.00Single6JODAngiotensin II6JOD-AT2-Angiotensin II
30.00Single7AD3Alpha-factor mating pheromone7AD3-STE2-α-factor mating pheromone-Gi1/STE4/γ2
30.00Single7DD7Ca; Ca; Tryptophan; Evocalcet7DD7-CaS-Ca-Ca; Ca; Tryptophan; Evocalcet
30.00Single7DW9AVP7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
30.00Single7EJKOxymetazoline7EJK-α2a-Oxymetazoline-Go/β1/γ2
30.00Single7WUIIP157WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2
30.00Single7YONPeptide-YY(3-36)7YON-Y2-Peptide-YY(3-36)-Gi1/β1/γ2
30.00Single8GH1Constrained Epinephrine8GH1-β2-Constrained Epinephrine
30.00Single8IEDA1LYA8IED-GPR156-A1LYA-Go/β1/γ2
30.00Single8IHFMK68928IHF-HCA2-MK6892-Gi1/β1/γ2
30.00Single8IW72-Phenylethylamine8IW7-TA9-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
30.00Single8WC62-Phenylethylamine8WC6-TA1-2-Phenylethylamine-chim(NtGi1-Gs)/β1/γ2
30.00Single8WC9ZH86518WC9-TA1-ZH8651-chim(NtGi1-Gs-CtGq)/β1/γ2
30.00Single8WSTPro-MCH8WST-MCH2-Pro-MCH-chim(NtGi1L-Gs-CtGq)/β1/γ2
30.00Single8X8LCortistatin8X8L-SST5-Cortistatin-chim(NtGi1-Gs-CtGi1)/β1/γ2
30.00Single8YN9Histamine8YN9-H4-Histamine-Gi1/β1/γ2
30.00Single8YUUHistamine8YUU-H3-Histamine-Gi1/β1/γ1
30.00Single9LRCHistamine9LRC-H4-Histamine
30.00Single9LREHistamine9LRE-H4-Histamine-Gi1/β1/γ2
30.00Consensusc5a1_on_gpOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
30.00Consensusfpr2-alx_on_gpOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
30.00Consensusgi_formylpeptideOrthosteric Ligand7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
30.00Consensusgs_vasop-oxyOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
30.00Consensush3_onOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
30.00Consensush3_on_gpOrthosteric Ligand8YUU-H3-Histamine-Gi1/β1/γ1
30.00Consensusv2_onOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
30.00Consensusv2_on_gpOrthosteric Ligand7DW9-V2-AVP-chim(NtGi1-Gs)/β1/γ2
30.00Consensusvasop-oxy_onOrthosteric Ligandv2_on
30.00Consensusvasop-oxy_on_gpOrthosteric Ligandv2_on_gp
29.63Single7RKFFractalkine7RKF-US28-Fractalkine-GDP-chim(NtGi1-G11)/β1/γ2
29.63Single7RMGSubstance-P7RMG-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
29.63Single7RMHSubstance-P7RMH-NK1-Substance-P-Gs/β1/γ2
29.63Single7S8LCortistatin-147S8L-MRGPRX2-Cortistatin-14-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.63Single7T11Octreotide7T11-SST2-Octreotide-Gi3/β1/γ2
29.63Single8H4IDoconexent8H4I-FFA4-Doconexent-chim(NtGi1-Gs)/β1/γ2
29.63Single9IPYJR14a9IPY-C3aB-JR14a
29.63Single9MD1Buspirone9MD1-5-HT1A-Buspirone-Gz/β1/γ2
29.63Consensusformylpeptide_onOrthosteric Ligandfpr2-alx_on fpr1-alx_on
29.41Single5GLHEndothelin-15GLH-ETB-Endothelin-1
29.41Single6IGKEndothelin-36IGK-ETB-Endothelin-3
29.41Single6PB0Urocortin6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2
29.41Consensusccr5_on_gpOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
29.41Consensusgi_endothelinOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
29.41Consensusgi_npyOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1 7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2 7YOO-Y2-Neuropeptide-Y-Gi1/β1/γ2
29.41Consensusnpy_onOrthosteric Ligandnpy1_on npy2_on npy4_on
29.41Consensusnpy_on_gpOrthosteric Ligandnpy1_on_gp npy2_on_gp npy4_on_gp
29.17Single2Y00Dobutamine2Y00-β1-Dobutamine
29.17Single5IUAQ274563485IUA-A2A-Q27456348-Na
29.17Single5N2SPSB365N2S-A1-PSB36
29.17Single6LPLZM-2413856LPL-A2A-ZM-241385-Na
29.17Single6ME72-Phenylmelatonin6ME7-MT2-2-Phenylmelatonin
29.17Single6OIKIperoxo6OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
29.17Single6S0QZM-2413856S0Q-A2A-ZM-241385
29.17Single6WQAZM-2413856WQA-A2A-ZM-241385-Na
29.17Single7C61Ergotamine7C61-5-HT1B-Ergotamine
29.17Single7EUOfMLF7EUO-FPR1-ALX-fMLF-Gi1/β1/γ2
29.17Single7RM5ZM-2413857RM5-A2A-ZM-241385-Na
29.17Single7SINNPS-21437SIN-CaS-NPS-2143
29.17Single7SINNPS-21437SIN-CaS-NPS-2143
29.17Single7VOEAripiprazole7VOE-5-HT2A-Aripiprazole
29.17Single7X1TTaltirelin7X1T-TRH-Taltirelin-chim(NtGi2L-Gs-CtGq)/β1/γ2
29.17Single8FYNZM-2413858FYN-A2A-ZM-241385-Na
29.17Single8GNEKW-63568GNE-A2A-KW-6356-Na
29.17Single8HNLPS3724248HNL-CXCR3-PS372424-Gi1/β1/γ2
29.17Single8ID4Linoleic acid8ID4-FFA4-Linoleic acid-Gi1/β1/γ2
29.17Single8KFXLMD-0098KFX-CCR8-LMD-009-Gi1/β1/γ2
29.17Single8QOTNanobody-E8QOT-μ-Nanobody-E
29.17Single8S4DCMF-0198S4D-Apelin-CMF-019
29.17Single8UUJFCH-22964138UUJ-HCA2-FCH-2296413-Gi1/β1/γ2
29.17Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
29.17Single8X0DVU04244658X0D-mGlu5; mGlu5-Quisqualate-VU0424465
29.17Single8YH0NECA8YH0-A3A-NECA-Gi1/β1/γ2
29.17Single8YNSSNAP-948478YNS-MCH1-SNAP-94847
29.17Single8ZMFA1L108ZMF-5-HT2C-A1L10
29.17Single8ZPTPrRP208ZPT-PrRP-PrRP20-chim(NtGi1-Gs-CtGq)/β1/γ2
29.17Single8ZRKGSK-12922638ZRK-GPR119-GSK-1292263-Gs/β1/γ2
29.17Single9CIBFCH-22964139CIB-HCA2-FCH-2296413
29.17Single9DYDAsenapine9DYD-5-HT1A-Asenapine-Go/β1/γ2
29.17Single9DYFAsenapine9DYF-5-HT1A-Asenapine-Gi1/β1/γ2
29.17Single9EHSLUF76029EHS-A3A-LUF7602
29.17Single9F34FOB02-04A9F34-D3-FOB02-04A-Go/β1/γ2
29.17Single9GE2ML1849GE2-GPR55-ML184-chim(NtGi1-G13)/β1/γ2
29.17Single9KPFSA09KPF-TAS2R16-SA0-Gi1/β1/γ2
29.17Consensusa1_offOrthosteric Ligand5UEN-A1-DU172 5N2S-A1-PSB36
29.17Consensusa3_on_gpOrthosteric Liganda3a_on_gp
29.17Consensusa3a_onOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
29.17Consensusa3a_on_gpOrthosteric Ligand8X17-A3A-Namodenoson-Gi1/β1/γ2 8X16-A3A-Piclidenoson-Gi1/β1/γ2
29.17Consensusd2_onOrthosteric Ligand7JVR-D2-Bromoergocryptine-Gi1/β1/γ2 8IRS-D2-Rotigotine-Gi1/β1/γ2
29.17Consensusgq_muscarinicOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
29.17Consensuslpa1_onOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
29.17Consensuslpa1_on_gpOrthosteric Ligand7TD1-LPA1-LPA-Gi1/β1/γ2 7YU3-LPA1-ONO-0740556-Gi1/β1/γ2
29.17Consensusm1_onOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
29.17Consensusnucleotide_onOrthosteric Ligandadenosine_on p2y_on
29.17Consensusrxfp4_onOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
29.17Consensusrxfp4_on_gpOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
29.17Consensuss1p5_offOrthosteric Ligand7YXA-S1P5-ONO-5430608
29.03Single7X9CPancreatic Hormone7X9C-Y4-Pancreatic Hormone-Gi1/β1/γ2
29.03Single7Y64C5a anaphylatoxin7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
29.03Single8HNKCXCL118HNK-CXCR3-CXCL11-Gi1/β1/γ2
29.03Single8WWKMCH8WWK-MCH1-MCH-Gi1/β1/γ2
28.95Consensusmc2_onOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
28.95Consensusmc2_on_gpOrthosteric Ligand8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
28.57Single3PBLEticlopride3PBL-D3-Eticlopride
28.57Single4IARErgotamine4IAR-5-HT1B-Ergotamine
28.57Single6HLLCP999946HLL-NK1-CP99994
28.57Single6PH7Nerol6PH7-Rhodopsin-Nerol-Gt(CT)
28.57Single6QNOAll-trans-Retinal6QNO-Rhodopsin-All-trans-Retinal-Gi1/β1/γ1
28.57Single6TQ4PubChem 160468446TQ4-OX1-PubChem 16046844-Na
28.57Single6WIVPubChem 52923113; PubChem 529246456WIV-GABAB1, GABAB2-PubChem 52923113; PubChem 52924645
28.57Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
28.57Single7E2YSerotonin7E2Y-5-HT1A-Serotonin-Gi1/β1/γ2
28.57Single7F54Afamelanotide7F54-MC4-Afamelanotide-Gs/β1/γ2
28.57Single7SRQLSD7SRQ-5-HT2B-LSD
28.57Single7T6UCGEN-855A7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2
28.57Single7VUIJNJ-635330547VUI-GPR139-JNJ-63533054-GTP-chim(Gs-CtGq)/β1/γ2
28.57Single7W0PElabela7W0P-Apelin-Elabela-Gi1/β1/γ2
28.57Single7XAUOctreotide7XAU-SST2-Octreotide-Gi1/β1/γ2
28.57Single7XP6Strychnine7XP6-TAS2R46-Strychnine-chim(Gs-CtGt3)/β1/γ2
28.57Single7YFDImetit7YFD-H4-Imetit-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single7YS6Serotonin7YS6-5-HT6-Serotonin-chim(NtGi1-Gs)/β1/γ2
28.57Single8DPFLorcaserin8DPF-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
28.57Single8GGYConstrained Epinephrine8GGY-β2-Constrained Epinephrine
28.57Single8H2GNiacin8H2G-HCA2-Niacin-Gi1/β1/γ2
28.57Single8HN8Histamine8HN8-H4-Histamine-Gi1/β1/γ2
28.57Single8IEIA1LYA8IEI-GPR156-A1LYA
28.57Single8IEPA1LYA8IEP-GPR156-A1LYA
28.57Single8IEPA1LYA8IEP-GPR156-A1LYA
28.57Single8JPNCis-Epoxysuccinic acid8JPN-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ1
28.57Single8K3ZCXCL128K3Z-CXCR4-CXCL12-Gi1/β1/γ1
28.57Single8K5BNiacin8K5B-HCA2-Niacin
28.57Single8KIGSHU91198KIG-MC3-SHU9119-Ca
28.57Single8UO4Constrained Epinephrine8UO4-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
28.57Single8WP1Cis-Epoxysuccinic acid8WP1-Succinate-Cis-Epoxysuccinic acid-Gi1/β1/γ2
28.57Single8WZ2Orexigenic Neuropeptide QRFP8WZ2-QRFP-Orexigenic Neuropeptide QRFP-chim(NtGi1L-Gs-CtGq)/β1/γ2
28.57Single8XBHS3E-LysoPS8XBH-GPR34-S3E-LysoPS-Gi1/β1/γ2
28.57Single8YKWSuccinic acid8YKW-Succinate-Succinic acid-Gi1/β1/γ1
28.57Single8YN5Histamine8YN5-H3-Histamine-Gi1/β1/γ2
28.57Single8YN6Imetit8YN6-H3-Imetit-Gi1/β1/γ2
28.57Single8YN7Immethridine8YN7-H3-Immethridine-Go/β1/γ2
28.57Single8ZBJSomatostatin-148ZBJ-SST5-Somatostatin-14-Gi1/β1/γ2
28.57Single8ZCJPasireotide8ZCJ-SST5-Pasireotide-Gi1/β1/γ1
28.57Single9AS2DMT9AS2-5-HT2A-DMT-chim(NtGi1-Gs-CtGq)/β1/γ2
28.57Single9AS7Psilocin9AS7-5-HT2A-Psilocin
28.57Single9C1PCa; Tryptophan; '6218; PO49C1P-CaS-Ca-Ca; Tryptophan; '6218; PO4
28.57Single9L3ZLRH7-C29L3Z-CML1-LRH7-C2
28.57Consensuscxcr4_onOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
28.57Consensusd3_offOrthosteric Ligand3PBL-D3-Eticlopride
28.57Consensusetb_on_gpOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
28.57Consensusgi_nucleotideOrthosteric Ligandgi_adenosine gi_p2y
28.57Consensush4_onOrthosteric Ligand8HN8-H4-Histamine-Gi1/β1/γ2 8HOC-H4-Imetit-Gi1/β1/γ2 8JXV-H4-Clozapine-Gi1/β1/γ2 8JXW-H4-VUF6884-Gi1/β1/γ2 8JXX-H4-Clobenpropit-Gi1/β1/γ2
28.57Consensusmc4_onOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
28.12Single7F8VGastrin-177F8V-CCKB-Gastrin-17-Gi2/β1/γ2
28.12Single7RGPTirzepatide7RGP-GLP-1-Tirzepatide-chim(NtGi1-Gs)/β1/γ2
28.12Single7YKDChemerin-97YKD-CML1-Chemerin-9-Gi1/β1/γ2
28.12Single8H0PNMB308H0P-BB1-NMB30-chim(NtGi1-Gs-CtGq)/β1/γ2
28.12Single8XQFApelin-138XQF-Apelin-Apelin-13-Gi1/β1/γ2
28.12Single9KFKRelaxin-39KFK-RXFP4-Relaxin-3-Gi2/β1/γ2
28.00Single6O3CCholesterol6O3C-SMO-SAG21k-Cholesterol
28.00Single6OIJIperoxo6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
28.00Single7EW4CYM55417EW4-S1P3-CYM5541-Gi1/β1/γ2
28.00Single7F58THIQ7F58-MC4-THIQ-Gs/β1/γ2
28.00Single7PX4PSB-21137PX4-A2A-PSB-2113
28.00Single7XAVLanreotide7XAV-SST2-Lanreotide-Gi1/β1/γ2
28.00Single7Y24Octreotide7Y24-SST2-Octreotide-Go/β1/γ2
28.00Single8IHHLUF62838IHH-HCA2-LUF6283-Gi1/β1/γ2
28.00Single8VVEnorBNI8VVE-κ-norBNI-Gi1/β1/γ2
28.00Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
28.00Single8X16Piclidenoson8X16-A3A-Piclidenoson-Gi1/β1/γ2
28.00Single8XBIS3E-LysoPS8XBI-GPR34-S3E-LysoPS
28.00Single8XZICMF-0198XZI-Apelin-CMF-019-Gi1/β1/γ2
28.00Single8ZWFJR14a8ZWF-C3aB-JR14a
28.00Single9ASTLymphotactin9AST-XCR1-Lymphotactin-Gi1/β1/γ2
28.00Single9UY3Anamorelin9UY3-Ghrelin-Anamorelin-chim(NtGi1-Gs-CtGq)/β1/γ2
28.00Consensuscyslt1_offOrthosteric Ligand6RZ5-CysLT1-Zafirlukast-Na 6RZ4-CysLT1-Pranlukast-Na
28.00Consensusffa_onOrthosteric Ligandffa2_on ffa3_on
28.00Consensusffa_on_gpOrthosteric Ligandffa2_on_gp ffa3_on_gp
28.00Consensusgi_ffaOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2 8J22-FFA2-TUG-1375-Gi1/β1/γ2
28.00Consensusgi_relaxinOrthosteric Ligand7YK7-RXFP4-DC591053-Gi2/β1/γ2 7YJ4-RXFP4-INSL5-Gi2/β1/γ2 7YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
28.00Consensusm1_on_gpOrthosteric Ligand6OIJ-M1-Iperoxo-chim(NtGi1L-G11)/β1/γ2
28.00Consensusmotilin_onOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
28.00Consensusnpy_offOrthosteric Ligandnpy1_off npy2_off
28.00Consensusrelaxin_onOrthosteric Ligandrxfp4_on
28.00Consensusrelaxin_on_gpOrthosteric Ligandrxfp4_on_gp
27.78Consensuscrf1_on_gpOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
27.59Single7PIVSetmelanotide7PIV-MC4-Setmelanotide-Gs/β1/γ2
27.59Single7RMISubstance-P7RMI-NK1-Substance-P-chim(Gs-CtGq)/β1/γ2
27.59Single7WJ5Somatostatin-147WJ5-SST2-Somatostatin-14-Gi1/β1/γ2
27.59Single7XMSSomatostatin-147XMS-SST4-Somatostatin-14-Gi1/β1/γ2
27.59Single8IEBA1LYA8IEB-GPR156-A1LYA
27.59Single9J0FNADH9J0F-P2Y14-NADH-Gi1/β1/γ2
27.59Consensusccr8_on_gpOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
27.59Consensusgi_cckOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
27.59Consensusmc4_on_gpOrthosteric Ligand7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2 7F58-MC4-THIQ-Gs/β1/γ2 7F54-MC4-Afamelanotide-Gs/β1/γ2 7F53-MC4-α-MSH-Gs/β1/γ2 7F55-MC4-Bremelanotide-Gs/β1/γ2
27.59Consensusmc5_onOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
27.27Single1GZM11-cis-Retinal1GZM-Rhodopsin-11-cis-Retinal
27.27Single2PED9-cis-Retinal2PED-Rhodopsin-9-cis-Retinal
27.27Single2X72All-trans-Retinal2X72-Rhodopsin-All-trans-Retinal-Gt(CT)
27.27Single3C9L11-cis-Retinal3C9L-Rhodopsin-11-cis-Retinal
27.27Single3PWHZM-2413853PWH-A2A-ZM-241385
27.27Single5K2DZM-2413855K2D-A2A-ZM-241385-Na
27.27Single5OLVLUAA410635OLV-A2A-LUAA41063-Na
27.27Single5ZKQABT-4915ZKQ-PAF-ABT-491
27.27Single6JZHZM-2413856JZH-A2A-ZM-241385-Na
27.27Single6ME2Ramelteon6ME2-MT1-Ramelteon
27.27Single6P9XCorticoliberin6P9X-CRF1-Corticoliberin-Gs/β1/γ2
27.27Single6PS7ZM-2413856PS7-A2A-ZM-241385-Na
27.27Single7DHRIsoprenaline7DHR-β2-Isoprenaline-Gs/β1/γ2
27.27Single7EIBDes-Arg10-Kallidin7EIB-BK1-Des-Arg10-Kallidin-chim(NtGi1-Gs-CtGq)/β1/γ2
27.27Single7EJ0L-Norepinephrine7EJ0-α2a-L-Norepinephrine-Go/β1/γ2
27.27Single7LJDDopamine7LJD-D1-Dopamine-Mevidalen-Gs/β1/γ1
27.27Single7M3FCa; Ca; Tryptophan; Cinacalcet; PO47M3F-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4
27.27Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
27.27Single7SILCa; Ca; Ca; Cyclomethyltryptophan; 9IG; PO47SIL-CaS-Ca-Ca; Ca; Ca; Cyclomethyltryptophan; 9IG; PO4
27.27Single7TUZ7-alpha,25-dihydroxycholesterol7TUZ-GPR183-7-α,25-dihydroxycholesterol-Gi1/β1/γ2
27.27Single7VUJJNJ-635330547VUJ-GPR139-JNJ-63533054-GDP-chim(Gs-CtGq)/β1/γ2
27.27Single8DWGML3828DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
27.27Single8FYXBuspirone8FYX-5-HT1A-Buspirone-Gi1/β1/γ1
27.27Single8GGCConstrained Epinephrine8GGC-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
27.27Single8GGWConstrained Epinephrine8GGW-β2-Constrained Epinephrine
27.27Single8IW4Spermidine8IW4-TA9-Spermidine-chim(NtGi1-Gs)/β1/γ2
27.27Single8IWESpermidine8IWE-TA9-Spermidine
27.27Single8J6LNiacin8J6L-HCA2-Niacin-Gi1/β1/γ2
27.27Single8JPPSuccinic acid8JPP-Succinate-Succinic acid-chim(Gs-CtGq)/β1/γ1
27.27Single8W8WAlpha-MSH8W8W-MC3-α-MSH-Ca-Gs/β1/γ2
27.27Single8WOGSuccinic acid8WOG-Succinate-Succinic acid-Gi1/β1/γ2
27.27Single8WWLMCH8WWL-MCH1-MCH-Gi1/β1/γ2
27.27Single8XWPEndothelin-18XWP-ETB-Endothelin-1-Gi1/β1/γ2
27.27Single8YKXMaleic acid8YKX-Succinate-Maleic acid-Gi1/β1/γ1
27.27Single8YUVImmepip8YUV-H3-Immepip-Gi1/β1/γ2
27.27Single9AVLCa; Ca; Cyclomethyltryptophan; 9IG; PO49AVL-CaS-Ca-Ca; Ca; Cyclomethyltryptophan; 9IG; PO4-Gi3/β2/γ2
27.27Single9EBHAdenosine9EBH-A3A-Adenosine-Gi1/β1/γ2
27.27Single9K6LSA09K6L-TAS2R16-SA0-Gi2/β1/γ2
27.27Consensusgi_succinateOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
27.27Consensusgq_histamineOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
27.27Consensush1_on_gpOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
27.27Consensuspaf_offOrthosteric Ligand5ZKQ-PAF-ABT-491
27.27Consensusrhodopsin_offOrthosteric Ligand1U19-Rhodopsin-11-cis-Retinal 2PED-Rhodopsin-9-cis-Retinal 5TE5-Rhodopsin-20-Methanoretinal
27.27Consensussuccinate_onOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
27.27Consensussuccinate_on_gpOrthosteric Ligand8YKW-Succinate-Succinic acid-Gi1/β1/γ1 8YKX-Succinate-Maleic acid-Gi1/β1/γ1
27.03Single9JR3PTH9JR3-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.92Single4N4WSANT-14N4W-SMO-SANT-1
26.92Single4PXZ2MeSADP4PXZ-P2Y12-2MeSADP
26.92Single5X33BIIL2605X33-BLT1-BIIL260
26.92Single6CM4Risperidone6CM4-D2-Risperidone
26.92Single7F55Bremelanotide7F55-MC4-Bremelanotide-Gs/β1/γ2
26.92Single7T6BS1P7T6B-S1P2-S1P-chim(NtGi1L-G13)/β1/γ2
26.92Single7WCNAR2314537WCN-GPR119-AR231453-Gs/β1/γ2
26.92Single7XW9TRH7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.92Single8IBUErythromycin-A8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
26.92Consensusc3a_onOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
26.92Consensusccr8_onOrthosteric Ligand8KFX-CCR8-LMD-009-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 8U1U-CCR8-CCL1-Gi1/β1/γ2
26.92Consensusgi_muscarinicOrthosteric Ligand8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7T8X-M2-Acetylcholine-chim(NtGi1-Go)/β1/γ2 7TRS-M4-Acetylcholine-Gi1/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2
26.92Consensusm4_onOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
26.92Consensusm4_on_gpOrthosteric Ligand7TRS-M4-Acetylcholine-Gi1/β1/γ2 7V6A-M4-PubChem 9864275-Gi1/β1/γ2 8E9X-M4-2-Deoxycytidine-chim(NtGi1-Go)/β1/γ2 7TRK-M4-Iperoxo-Gi1/β1/γ2
26.92Consensusmotilin_on_gpOrthosteric Ligand8IBU-Motilin-Erythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
26.92Consensustrh_onOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.92Consensustrh_on_gpOrthosteric Ligand7XW9-TRH-TRH-chim(NtGi1L-Gs-CtGq)/β1/γ2
26.83Consensuspth_on_gpOrthosteric Ligandpth1_on_gp pth2_on_gp
26.67Single8W8YGamma-MSH8W8Y-MC3-γ-MSH-Ca-Gs/β1/γ2
26.67Single9K27PrRP319K27-PrRP-PrRP31-chim(NtGi1-Gq)/β1/γ2
26.67Single9M1OMorphine-Modulating Neuropeptide B9M1O-NPFF2-Morphine-Modulating Neuropeptide B-Gi1/β1/γ2
26.67Consensusangiotensin_onOrthosteric Ligandat1_on
26.67Consensusat1_onOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
26.67Consensusc5a1_onOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
26.67Consensuscxcr4_on_gpOrthosteric Ligand8K3Z-CXCR4-CXCL12-Gi1/β1/γ1
26.67Consensusfpr2-alx_onOrthosteric Ligand7WVX-FPR2-ALX-Humanin-Gi2/β1/γ2 7T6U-FPR2-ALX-CGEN-855A-Gi1/β1/γ2 7T6V-FPR2-ALX-fMLFII-Gi1/β1/γ2 7WVY-FPR2-ALX-Amyloid-β42-Gi2/β1/γ2 7T6S-FPR2-ALX-PubChem 24776341-Gi1/β1/γ2 6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
26.47Single6PB1Urocortin6PB1-CRF2-Urocortin-chim(NtGi1-Gs)/β1/γ2
26.47Single7VGXNeuropeptide-Y7VGX-Y1-Neuropeptide-Y-Gi1/β1/γ2
26.47Single8KGGLPS8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
26.47Consensusbk2_onOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
26.47Consensusbk2_on_gpOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
26.47Consensusbradykinin_onOrthosteric Ligandbk2_on
26.47Consensusbradykinin_on_gpOrthosteric Ligandbk2_on_gp
26.47Consensusendothelin_onOrthosteric Ligandetb_on eta_on
26.47Consensusetb_onOrthosteric Ligand8IY5-ETB-Endothelin-1-Gi1/β1/γ2 8HBD-ETB-IRL1620-Gi1/β1/γ2
26.47Consensusgq_bradykininOrthosteric Ligand7F6H-BK2-Bradykinin-Gq/β1/γ2 7F6I-BK2-Kallidin-Gq/β1/γ2
26.09Single3OAX11-cis-Retinal3OAX-Rhodopsin-11-cis-Retinal
26.09Single3REYXAC3REY-A2A-XAC
26.09Single5IU4ZM-2413855IU4-A2A-ZM-241385-Na
26.09Single5IUBQ274563445IUB-A2A-Q27456344-Na
26.09Single5K2BZM-2413855K2B-A2A-ZM-241385-Na
26.09Single5K2CZM-2413855K2C-A2A-ZM-241385-Na
26.09Single5NLXZM-2413855NLX-A2A-ZM-241385-Na
26.09Single5NM4ZM-2413855NM4-A2A-ZM-241385-Na
26.09Single5UVIZM-2413855UVI-A2A-ZM-241385
26.09Single6ME32-Phenylmelatonin6ME3-MT1-2-Phenylmelatonin
26.09Single6ME42-Iodomelatonin6ME4-MT1-2-Iodomelatonin
26.09Single6MH8ZM-2413856MH8-A2A-ZM-241385
26.09Single6PS82-Phenylmelatonin6PS8-MT1-2-Phenylmelatonin
26.09Single6V9SGTPL114036V9S-OX1-GTPL11403
26.09Single6VI4JDTic6VI4-κ-JDTic
26.09Single6ZDVChromone 5d6ZDV-A2A-Chromone 5d-Na
26.09Single6ZG9GSK10347026ZG9-M1-GSK1034702
26.09Single7AROLUF58337ARO-A2A-LUF5833-Na
26.09Single7T32ZM-2413857T32-A2A-ZM-241385
26.09Single7UL3Famotidine7UL3-H2-Famotidine
26.09Single7VODCariprazine7VOD-5-HT2A-Cariprazine
26.09Single7YK6PubChem 1383196747YK6-RXFP4-PubChem 138319674-Gi2/β1/γ2
26.09Single7ZBC11-cis-Retinal7ZBC-Rhodopsin-11-cis-Retinal
26.09Single7ZBE11-cis-Retinal7ZBE-Rhodopsin-11-cis-Retinal
26.09Single8DPGPsilocin8DPG-5-HT2C-Psilocin-chim(NtGi2L-Gs-CtGq)/β1/γ2
26.09Single8GEAConstrained Epinephrine8GEA-β2-Constrained Epinephrine-Gs/β1/γ2
26.09Single8GG8Constrained Epinephrine8GG8-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
26.09Single8H4LDoconexent8H4L-FFA4-Doconexent-chim(NtGi1-Gs-CtGq)/β1/γ2
26.09Single8IY9Niacin8IY9-HCA2-Niacin-Go/β1/γ2
26.09Single8JEI3-nitro-4-(propylamino)benzoic acid8JEI-HCAR3-3-nitro-4-(propylamino)benzoic acid-Gi1/β1/γ2
26.09Single8JERAcipimox8JER-HCA2-Acipimox-Go/β1/γ2
26.09Single8RWCStilSwitch28RWC-A2A-StilSwitch2-Na
26.09Single8RWDStilSwitch38RWD-A2A-StilSwitch3-Na
26.09Single8RWIStilSwitch28RWI-A2A-StilSwitch2-Na
26.09Single8W8BSEP-3638568W8B-5-HT1A-SEP-363856-Gi1/β1/γ2
26.09Single8Y62C16:0 Ceramide8Y62-FPR2-ALX-C16:0 Ceramide-Gi1/β1/γ2
26.09Single8Y6YGLPG09748Y6Y-FFA2-GLPG0974
26.09Single9LRDHistamine9LRD-H1-Histamine-Gi1/β1/γ2
26.09Consensuscb1_offOrthosteric Ligand5U09-CB1-Taranabant 5TGZ-CB1-AM6538
25.93Single7EZHCholecystokinin-87EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
25.93Single7EZMCholecystokinin-87EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2
25.93Single7QVMOxytocin7QVM-OT-Oxytocin-chim(NtGi1-Go-CtGq)/β1/γ2
25.93Single7X1UTRH7X1U-TRH-TRH-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.93Single7X8RBOC57X8R-GLP-1-BOC5-Gs/β1/γ2
25.93Single7Y65C5a peptide7Y65-C5a1-C5a peptide-Gi1/β1/γ2
25.93Single8IULLatanoprost8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93Single8XJKCloprosetnol8XJK-FP-alpha-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
25.93Single9EAILosartan9EAI-AT1-Losartan-Nanobody AT209
25.93Consensusc3a_on_gpOrthosteric Ligand8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2
25.93Consensuscck_onOrthosteric Ligandccka_on cckb_on
25.93Consensuscck_on_gpOrthosteric Ligandccka_on_gp cckb_on_gp
25.93Consensusccka_onOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
25.93Consensusccka_on_gpOrthosteric Ligand7EZH-CCKA-Cholecystokinin-8-Gi1/β1/γ2
25.93Consensusprostanoid_offOrthosteric Ligandep_off dp_off
25.81Single5WB2CX3CL1.355WB2-US28-CX3CL1.35
25.81Single7F6GSAR1-AngII7F6G-AT1-SAR1-AngII-Gq/β1/γ2
25.81Single7FIMTirzepatide7FIM-GLP-1-Tirzepatide-Gs/β1/γ2
25.81Single7T10Somatostatin-147T10-SST2-Somatostatin-14-Gi3/β1/γ2
25.81Single7XK8Neuromedin-U-257XK8-NMUR2-Neuromedin-U-25-Gi1/β1/γ2
25.81Consensusangiotensin_on_gpOrthosteric Ligandat1_on_gp
25.81Consensusat1_on_gpOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
25.81Consensusgq_angiotensinOrthosteric Ligand7F6G-AT1-SAR1-AngII-Gq/β1/γ2
25.81Consensusmc5_on_gpOrthosteric Ligand8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2 8IOD-MC5-PG-901-Ca-chim(NtGi1-Gs)/β1/γ2
25.81Consensusp2y_on_gpOrthosteric Ligandp2y1_on_gp p2y10_on_gp p2y12_on_gp
25.81Consensusprotein_onOrthosteric Ligandchemokine_on chemerin_on
25.81Consensustachykinin_onOrthosteric Ligandnk1_on nk2_on nk3_on
25.71Consensuscrf1_onOrthosteric Ligand6PB0-CRF1-Urocortin-chim(NtGi1-Gs)/β1/γ2 6P9X-CRF1-Corticoliberin-Gs/β1/γ2
25.00Single4YAYZD-71554YAY-AT1-ZD-7155
25.00Single5UENDU1725UEN-A1-DU172
25.00Single6C1QPMX536C1Q-C5a1-PMX53-NDT9513727
25.00Single6LPJZM-2413856LPJ-A2A-ZM-241385-Na
25.00Single6LPKZM-2413856LPK-A2A-ZM-241385-Na
25.00Single6OY9All-trans-Retinal6OY9-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
25.00Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
25.00Single6Z10PubChem 1545855546Z10-Succinate-PubChem 154585554
25.00Single7DD5Ca; Ca; Tryptophan; NPS-21437DD5-CaS-Ca-Ca; Ca; Tryptophan; NPS-2143
25.00Single7F16TIP397F16-PTH2-TIP39-Gs/β1/γ2
25.00Single7F6HBradykinin7F6H-BK2-Bradykinin-Gq/β1/γ2
25.00Single7F8WGastrin-177F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
25.00Single7F9YGhrelin-287F9Y-Ghrelin-Ghrelin-28-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7F9ZGHRP-67F9Z-Ghrelin-GHRP-6-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single7PP1Selatogrel7PP1-P2Y12-Selatogrel
25.00Single7WC8Lumateperone7WC8-5-HT2A-Lumateperone
25.00Single7X9BNeuropeptide-Y7X9B-Y2-Neuropeptide-Y-Gi1/β1/γ2
25.00Single7XN9L-054,5227XN9-SST2-L-054,522
25.00Single7YACPaltusotine7YAC-SST2-Paltusotine-Gi1/β1/γ2
25.00Single7YJ4INSL57YJ4-RXFP4-INSL5-Gi2/β1/γ2
25.00Single7YXAONO-54306087YXA-S1P5-ONO-5430608
25.00Single8DPHLorcaserin8DPH-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8GY7Corticotropin8GY7-MC2-Corticotropin-Ca-chim(NtGi1-Gs)/β1/γ2; MRAP1
25.00Single8HCQEndothelin-18HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8HCXEndothelin-18HCX-ETB-Endothelin-1-chim(NtGi2L-Gs-CtGq)/β1/γ2
25.00Single8HK5Complement C58HK5-C5a1-Complement C5-Gi1/β1/γ2
25.00Single8IA2C5a anaphylatoxin8IA2-C5a1-C5a anaphylatoxin-Go/β1/γ2
25.00Single8IA7Cholecystokinin-88IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2
25.00Single8IUMTafluprost acid8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8IWM2-Phenylethylamine8IWM-TA9-2-Phenylethylamine
25.00Single8JBFSenktide8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Single8JHNMMF8JHN-HCA2-MMF-Go/β1/γ2
25.00Single8JT8(R)-IHCH-71798JT8-5-HT2A-(R)-IHCH-7179
25.00Single8K5DGSK2560738K5D-HCA2-GSK256073
25.00Single8KFYZK-7563268KFY-CCR8-ZK-756326-Gi1/β1/γ2
25.00Single8RW7StilSwitch18RW7-A2A-StilSwitch1-Na
25.00Single8RWXStilSwitch38RWX-A2A-StilSwitch3-Na
25.00Single8WC5Tetramethylammonium Ion8WC5-TA1-Tetramethylammonium Ion-chim(NtGi1-Gs)/β1/γ2
25.00Single8X9TAP5038X9T-ADGRD1-AP503-chim(NtGi1-Gs)/β1/γ2
25.00Single8XVHEndothelin-18XVH-ETB-Endothelin-1-chim(Gs-CtGq)/β1/γ2
25.00Single8XZFWN5618XZF-Apelin-WN561-Gi1/β1/γ2
25.00Single8ZBEOctreotide8ZBE-SST5-Octreotide-Gi1/β1/γ1
25.00Single8ZQEGPR15L(C11)8ZQE-GPR15-GPR15L(C11)-Gi1/β1/γ1
25.00Single9IZCMK19039IZC-HCA2-MK1903-Gi1/β1/γ2
25.00Single9JGKBalovaptan9JGK-5-HT2B-Balovaptan
25.00Single9JH6C20:0 Ceramide9JH6-CysLT2-C20:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensuscck_offOrthosteric Ligandccka_off
25.00Consensusccka_offOrthosteric Ligand7F8Y-CCKA-Devazepide 7F8U-CCKA-Lintitript
25.00Consensuscml1_on_gpOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
25.00Consensusendothelin_on_gpOrthosteric Ligandetb_on_gp eta_on_gp
25.00Consensuseta_onOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensuseta_on_gpOrthosteric Ligand8HCQ-ETA-Endothelin-1-chim(NtGi1-Gs-CtGq)/β1/γ2
25.00Consensuspth2_on_gpOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
24.24Single7W3ZGastrin Releasing Peptide7W3Z-BB2-Gastrin Releasing Peptide-chim(NtGi1L-Gq)/β1/γ2
24.24Consensuscrf2_on_gpOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
24.24Consensusgi_compl-peptOrthosteric Ligand8HK5-C5a1-Complement C5-Gi1/β1/γ2 8IA8-C3aB-E7 peptide-Gi1/β1/γ2 7Y66-C5a1-BM213-Gi1/β1/γ2 7Y67-C5a1-C089 peptide-Gi1/β1/γ2 8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2 7Y64-C5a1-C5a anaphylatoxin-Gi1/β1/γ2
24.24Consensusgi_proteinOrthosteric Ligandgi_chemokine gi_chemerin
24.24Consensusprotein_on_gpOrthosteric Ligandchemokine_on_gp chemerin_on_gp
24.14Single4XT1Fractalkine4XT1-US28-Fractalkine
24.14Single6RZ8ONO-20803656RZ8-CysLT2-ONO-2080365
24.14Single7F8XNN90567F8X-CCKA-NN9056
24.14Single7NA7Ghrelin-277NA7-Ghrelin-Ghrelin-27-Gi1/β1/γ2
24.14Single7W2ZGhrelin7W2Z-Ghrelin-Ghrelin-Go/β1/γ2
24.14Single8IEIA1LYA8IEI-GPR156-A1LYA
24.14Single8IZBLysophosphatidylserine8IZB-GPR174-Lysophosphatidylserine-Gs/β1/γ2
24.14Single9J0IUDP-Glucuronic acid9J0I-P2Y14-UDP-Glucuronic acid-Gi1/β1/γ2
24.14Consensuschemerin_on_gpOrthosteric Ligandcml1_on_gp
24.14Consensuscml1_onOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
24.14Consensusgi_chemerinOrthosteric Ligand7YKD-CML1-Chemerin-9-Gi1/β1/γ2
24.14Consensusnk3_onOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
24.14Consensusnk3_on_gpOrthosteric Ligand8JBF-NK3-Senktide-chim(NtGi1-Gs-CtGq)/β1/γ2
24.14Consensusp2y_onOrthosteric Ligandp2y1_on p2y10_on p2y12_on
24.00Single4NTJAZD12834NTJ-P2Y12-AZD1283
24.00Single4WW3All-trans-Retinal4WW3-Rhodopsin-All-trans-Retinal
24.00Single5CGCHTL142425CGC-mGlu5-HTL14242
24.00Single5N2RPSB-365N2R-A2A-PSB-36-Na
24.00Single6D26Fevipiprant6D26-DP2-Fevipiprant
24.00Single6LUQHaloperidol6LUQ-D2-Haloperidol
24.00Single6RZ4Pranlukast6RZ4-CysLT1-Pranlukast-Na
24.00Single7E9GJNJ-404118137E9G-mGlu2; mGlu2-Eglumetad-JNJ-40411813-Gi1/β1/γ2
24.00Single7VFXfMLF7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
24.00Single7VV4Cortistatin-147VV4-MRGPRX2-Cortistatin-14
24.00Single7WIGL-054,2647WIG-SST2-L-054,264-Gi1/β1/γ2
24.00Single7Y26Octreotide7Y26-SST2-Octreotide-chim(NtGi2L-Gs-CtGq)/β1/γ2
24.00Single8I7WGSK2560738I7W-HCA2-GSK256073-Gi1/β1/γ2
24.00Single8X0BVU04244658X0B-mGlu5; mGlu5-Quisqualate-VU0424465
24.00Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
24.00Single8X0CVU04244658X0C-mGlu5; mGlu5-Quisqualate-VU0424465
24.00Single9B9ZA1AKO9B9Z-CB1-A1AKO
24.00Single9IYBProstaglandin9IYB-DP2-Prostaglandin-A1D5Q-Gi1/β1/γ2
24.00Consensusblt1_offOrthosteric Ligand5X33-BLT1-BIIL260 7K15-BLT1-MKD046-Na
24.00Consensusblt_offOrthosteric Ligandblt1_off
24.00Consensusdp2_offOrthosteric Ligand6D26-DP2-Fevipiprant
24.00Consensusdp_offOrthosteric Liganddp2_off
24.00Consensusfpr1-alx_onOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
24.00Consensusfpr1-alx_on_gpOrthosteric Ligand7VFX-FPR1-ALX-fMLF-Gi1/β1/γ2
23.81Single3C9M11-cis-Retinal3C9M-Rhodopsin-11-cis-Retinal
23.81Single3OE6IT1t3OE6-CXCR4-IT1t
23.81Single3UZAGTPL92363UZA-A2A-GTPL9236
23.81Single5WKTOctyl-Beta-D-Glucopyranoside5WKT-Rhodopsin-Octyl-β-D-Glucopyranoside-Gt(CT)
23.81Single7F23Dopamine7F23-D1-Dopamine-GDP-Gs/β1/γ2
23.81Single7MT8All-trans-Retinal7MT8-Rhodopsin-All-trans-Retinal-GRK1
23.81Single7WC5Psilocin7WC5-5-HT2A-Psilocin
23.81Single8DPILorcaserin8DPI-5-HT2C-Lorcaserin-chim(NtGi2L-Gs-CtGq)/β1/γ2
23.81Single8GGEConstrained Epinephrine8GGE-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.81Single8GGFConstrained Epinephrine8GGF-β2-Constrained Epinephrine-GTP-Gs/β1/γ2
23.81Single8ITFDMCHA8ITF-TA9-DMCHA-chim(NtGi1-Gs)/β1/γ2
23.81Single8J21Butyric acid8J21-FFA3-Butyric acid-Gi1/β1/γ2
23.81Single8J24Acetic acid8J24-FFA2-Acetic acid-Gi1/β1/γ2
23.81Single8J6QBeta-Hydroxybutyrate8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
23.81Single8JXTHistamine8JXT-H4-Histamine-PO4-Gi1/β1/γ2
23.81Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
23.81Single9IV15alpha-DHT9IV1-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
23.81Consensusffa3_onOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
23.81Consensusffa3_on_gpOrthosteric Ligand8J21-FFA3-Butyric acid-Gi1/β1/γ2
23.68Single7X9ANeuropeptide-Y7X9A-Y1-Neuropeptide-Y-Gi1/β1/γ2
23.68Single7Y36Teriparatide7Y36-PTH1-Teriparatide-Gs/β1/γ2
23.68Single8FLQPTH8FLQ-PTH1-PTH-Gs/β1/γ2
23.68Consensusclass-a_class-b1_cons_on_gpOrthosteric Ligandclass-a_on_gp class-b1_on_gp
23.68Consensuspth2_onOrthosteric Ligand7F16-PTH2-TIP39-Gs/β1/γ2
23.53Single6B3JExendin-P56B3J-GLP-1-Exendin-P5-Gs/β1/γ2
23.53Single8W8XBeta-MSH8W8X-MC3-β-MSH-Ca-Gs/β1/γ2
23.53Consensuscrf_onOrthosteric Ligandcrf2_on crf1_on
23.53Consensusglp_onOrthosteric Ligandglp1_on glp2_on
23.53Consensusglp_on_gpOrthosteric Ligandglp1_on_gp glp2_on_gp
23.53Consensusp2y10_on_gpOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
23.33Single5XJM(Sar1,Ile8)-Angiotensin II5XJM-AT2-(Sar1,Ile8)-Angiotensin II
23.33Single6DO1Angiotensin-like peptide S1I86DO1-AT1-Angiotensin-like peptide S1I8
23.33Single7RKMFractalkine7RKM-US28-Fractalkine-Gi1/β1/γ2
23.33Single8JBHSubstance-P8JBH-NK3-Substance-P-chim(NtGi1-Gs-CtGq)/β1/γ2
23.33Single8SG1Chemerin-98SG1-CML1-Chemerin-9-Gi1/β1/γ2
23.33Single9E82SDF-1-beta9E82-ACKR3-SDF-1-β-Arrestin2
23.33Single9IQVMuscarinic toxin 39IQV-Alpha1A-Muscarinic toxin 3
23.33Single9KFIRelaxin-39KFI-RXFP3-Relaxin-3-Gi2/β1/γ2
23.33Consensuscckb_onOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
23.33Consensuscompl-peptide_onOrthosteric Ligandc5a1_on c3a_on
23.33Consensustachykinin_on_gpOrthosteric Ligandnk1_on_gp nk2_on_gp nk3_on_gp
23.08Single4IAQDihydroergotamine4IAQ-5-HT1B-Dihydroergotamine
23.08Single6RZ5Zafirlukast6RZ5-CysLT1-Zafirlukast-Na
23.08Single7M8W15r-Methyl-Prostaglandin D27M8W-DP2-15r-Methyl-Prostaglandin D2-Na
23.08Single7P2L4YI7P2L-mGlu5-4YI
23.08Single7S8MCortistatin-147S8M-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
23.08Single7Y67C089 peptide7Y67-C5a1-C089 peptide-Gi1/β1/γ2
23.08Single8HQCC5a anaphylatoxin8HQC-C5a1-C5a anaphylatoxin-Go/β1/γ2
23.08Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
23.08Single8X0FVU04244658X0F-mGlu5; mGlu5-Quisqualate-VU0424465
23.08Single8X79MRE-2698X79-I2-MRE-269-Gs/β1/γ2
23.08Single8XJMLatanoprost8XJM-FP-alpha-Latanoprost-chim(NtGi2-Gs-CtGq)/β1/γ2
23.08Single8YNTSNAP-948478YNT-MCH1-SNAP-94847
23.08Consensuspth_onOrthosteric Ligandpth1_on pth2_on
22.86Single5VAIGLP-15VAI-GLP-1-GLP-1-Gs/β1/γ2
22.86Single6NBHLong-Acting PTH Analog6NBH-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
22.86Single7D68GLP-27D68-GLP-2-GLP-2-Gs/β1/γ2
22.86Single8IY5Endothelin-18IY5-ETB-Endothelin-1-Gi1/β1/γ2
22.86Single8IY6Endothelin-18IY6-ETB-Endothelin-1
22.86Consensuspth1_onOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
22.73Single1L9H11-cis-Retinal1L9H-Rhodopsin-11-cis-Retinal
22.73Single1U1911-cis-Retinal1U19-Rhodopsin-11-cis-Retinal
22.73Single2G87All-trans-Retinal2G87-Rhodopsin-All-trans-Retinal
22.73Single2I3511-cis-Retinal2I35-Rhodopsin-11-cis-Retinal
22.73Single3OE9IT1t3OE9-CXCR4-IT1t
22.73Single5TE520-Methanoretinal5TE5-Rhodopsin-20-Methanoretinal
22.73Single6I9K9-cis-Retinal6I9K-Rhodopsin-9-cis-Retinal
22.73Single6PGSGeraniol6PGS-Rhodopsin-Geraniol-Gt(CT)
22.73Single7D76Beclomethasone7D76-ADGRG3-Beclomethasone-Go/β1/γ2
22.73Single7DFLHistamine7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
22.73Single7V68Iperoxo7V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
22.73Single8A2PLUAA470708A2P-A2A-LUAA47070-Na
22.73Single8IHIAcifran8IHI-HCA2-Acifran-Gi1/β1/γ2
22.73Single8JILNiacin8JIL-HCA2-Niacin-Gi1/β1/γ2
22.73Single8RWHStilSwitch28RWH-A2A-StilSwitch2-Na
22.73Single8SZFCa; Ca; Tryptophan; Cinacalcet; PO4; Spermine8SZF-CaS-Ca; Ca; Tryptophan; Cinacalcet; PO4; Spermine
22.73Single8UO3Constrained Epinephrine8UO3-β2-Constrained Epinephrine-GTP; Mg-Gs/β1/γ2
22.73Single8WPUTryptophan; Cinacalcet; PO4; Ca8WPU-CaS-Tryptophan; Cinacalcet; PO4; Ca-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.73Single8YH3N-methyladenosine8YH3-A3A-N-methyladenosine-Gi1/β1/γ2
22.73Single8YN2Histamine8YN2-H1-Histamine-chim(NtGi1L-Gs-CtGq)/β1/γ2
22.73Single9B9Y7DY9B9Y-CB1-7DY
22.73Single9EPRRetinal9EPR-Rhodopsin-Retinal-Gi1/β1/γ2
22.73Single9IQTNiacin9IQT-HCA2-Niacin-Gi1/β1/γ2
22.73Single9IZDCHBA9IZD-HCA1-CHBA-Gi1/β1/γ2
22.73Consensush1_onOrthosteric Ligand7DFL-H1-Histamine-chim(NtGi1L-Gq)/β1/γ2
22.58Single6LW5WKYMVm6LW5-FPR2-ALX-WKYMVm
22.58Single6MEOEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MEO-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
22.58Single7XOUCholecystokinin-87XOU-CCKA-Cholecystokinin-8-Gs/β1/γ2
22.58Single8K6MNeuropeptide-Y8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
22.58Consensuscckb_on_gpOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7F8V-CCKB-Gastrin-17-Gi2/β1/γ2
22.58Consensuscompl-peptide_on_gpOrthosteric Ligandc5a1_on_gp c3a_on_gp
22.58Consensusnpy1_onOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
22.58Consensusnpy1_on_gpOrthosteric Ligand8K6M-Y1-Neuropeptide-Y-Gi2/β1/γ1
22.22Single4PY02MeSATP4PY0-P2Y12-2MeSATP
22.22Single5TZYMK8666; AP85TZY-FFA1-MK8666; AP8
22.22Single6C1RPMX536C1R-C5a1-PMX53-Avacopan; Na
22.22Single6OS0Angiotensinogen6OS0-AT1-Angiotensinogen
22.22Single6RZ7ONO-25703666RZ7-CysLT2-ONO-2570366
22.22Single7DUQGLP-17DUQ-GLP-1-GLP-1-PubChem 156022738-Gs/β1/γ2
22.22Single7L1UOrexin7L1U-OX2-Orexin-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single7WCMMBX-29827WCM-GPR119-MBX-2982-Gs/β1/γ2
22.22Single7XW6ML1097XW6-TSH-M22 Fab-ML109-Gs/β1/γ2
22.22Single7Y66BM2137Y66-C5a1-BM213-Gi1/β1/γ2
22.22Single8H0QGastrin Releasing Peptide8H0Q-BB2-Gastrin Releasing Peptide-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single8IQ6Latanoprost8IQ6-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single8J6DEP1418J6D-C3aB-EP141-Go/β1/γ2
22.22Single8U1UCCL18U1U-CCR8-CCL1-Gi1/β1/γ2
22.22Single8U26Protachykinin-18U26-NK1-Protachykinin-1-Gs/β1/γ2
22.22Single8VHFMBX-29828VHF-GPR119-MBX-2982-Gs/β1/γ2
22.22Single8WRBLysophosphatidylserine8WRB-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
22.22Single8XJNCloprosetnol8XJN-TXA2-Cloprosetnol-chim(NtGi1-Gs-CtGq)/β1/γ2
22.22Single8XQSCholesterol8XQS-TAS2R14-Cholesterol-Flufenamic acid-Gi1/β1/γ1
22.22Single8Y6WTUG-13758Y6W-FFA2-TUG-1375-4-CMTB-Gi1/β1/γ2
22.22Single9BJKNAM9BJK-μ-Naloxone-NAM
22.22Single9GGGI-BOP9GGG-TXA2-I-BOP-chim(NtGi2L-Gs-CtGq)/β1/γ2
22.22Single9L3WRetinoic acid receptor responder protein 29L3W-CML1-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
22.22Consensusclass-a_class-b1_cons_onOrthosteric Ligandclass-a_on class-b1_on
22.22Consensusffa2_on_gpOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
21.88Single6METEnvelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd46MET-CCR5-Envelope Glycoprotein Gp160; T-Cell Surface Glycoprotein Cd4
21.88Single6WI9Secretin6WI9-Secretin-Secretin-Gs/β1/γ2
21.88Single7V9MSomatoliberin7V9M-GHRH (SV1)-Somatoliberin-Gs/β1/γ2
21.88Single8YW3Retatrutide8YW3-GLP-1-Retatrutide-Gs/β1/γ2
21.88Single8YW5Retatrutide8YW5-Glucagon-Retatrutide-Gs/β1/γ2
21.88Consensusapelin_onOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
21.88Consensusapelin_on_gpOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
21.74Single3ODUIT1t3ODU-CXCR4-IT1t
21.74Single3VG9ZM-2413853VG9-A2A-ZM-241385-Antibody
21.74Single5OLHVipadenant5OLH-A2A-Vipadenant-Na
21.74Single5OLOTozadenant5OLO-A2A-Tozadenant-Na
21.74Single5U09Taranabant5U09-CB1-Taranabant
21.74Single6FKBPubChem 1324730386FKB-Rhodopsin-PubChem 132473038
21.74Single6ME9Ramelteon6ME9-MT2-Ramelteon
21.74Single6OYAAll-trans-Retinal6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
21.74Single6RNKNF-56-EJ406RNK-Succinate-NF-56-EJ40
21.74Single7F8ULintitript7F8U-CCKA-Lintitript
21.74Single7VDLCortistatin-147VDL-MRGPRX2-Cortistatin-14-Gi1/β1/γ2
21.74Single7W0MPubChem 1227019087W0M-Apelin-PubChem 122701908-Gi1/β1/γ2
21.74Single8A6CAll-trans-Retinal8A6C-Rhodopsin-All-trans-Retinal
21.74Single8A6DAll-trans-Retinal8A6D-Rhodopsin-All-trans-Retinal
21.74Single8A6EAll-trans-Retinal8A6E-Rhodopsin-All-trans-Retinal
21.74Single8GNGIstradefylline8GNG-A2A-Istradefylline
21.74Single8IJANiacin8IJA-HCA2-Niacin-Gi1/β1/γ2
21.74Single8IJBAcipimox8IJB-HCA2-Acipimox-Gi1/β1/γ2
21.74Single8J20Valeric acid8J20-FFA3-Valeric acid-AR420626-Gi1/β1/γ2
21.74Single8RVWStilSwitch38RVW-A2A-StilSwitch3-Na
21.74Single8RW0Istradefylline8RW0-A2A-Istradefylline-Na
21.74Single8RW4AzoSwitch28RW4-A2A-AzoSwitch2-Na
21.74Single8RWEStilSwitch48RWE-A2A-StilSwitch4-Na
21.74Single8T3SButyric acid8T3S-FFA2-Butyric acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
21.74Single8UTDMK19038UTD-HCA2-MK1903-Gi1/β1/γ2
21.74Single9FUPIstradefylline9FUP-A2A-Istradefylline-Na
21.74Consensusrhodopsin_on_gpOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
21.74Consensussensory_offonOrthosteric Ligandsensory_off sensory_on
21.74Consensussensory_offon_gpOrthosteric Ligandsensory_on_gp sensory_on
21.62Single6LPBPACAP6LPB-PAC1-PACAP-Gs/β1/γ1
21.62Single8FLSAbaloparatide8FLS-PTH1-Abaloparatide-Gs/β1/γ2
21.62Single8FLULong-Acting PTH8FLU-PTH1-Long-Acting PTH-Gs/β1/γ2
21.62Single9AUCCalcitonin gene-related peptide-19AUC-CT (AMY1)-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
21.43Single5CGDHTL142425CGD-mGlu5-HTL14242
21.43Single6RZ9ONO-27703726RZ9-CysLT2-ONO-2770372
21.43Single7D7MDinoprostone7D7M-EP4-Dinoprostone-Gs/β1/γ1
21.43Single7MBYCholecystokinin-87MBY-CCKA-Cholecystokinin-8-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.43Single7PIUSetmelanotide7PIU-MC4-Setmelanotide-Gs/β1/γ2
21.43Single8XBES3E-LysoPS8XBE-GPR34-S3E-LysoPS-Gi1/β1/γ1
21.43Single8XJOU466198XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Consensuschemerin_onOrthosteric Ligandcml1_on
21.43Consensuscyslt2_offOrthosteric Ligand6RZ7-CysLT2-ONO-2570366 6RZ8-CysLT2-ONO-2080365 6RZ9-CysLT2-ONO-2770372
21.43Consensusfp-alpha_onOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Consensusfp-alpha_on_gpOrthosteric Ligand8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUL-FP-alpha-Latanoprost-chim(NtGi1-Gs-CtGq)/β1/γ2 8IUM-FP-alpha-Tafluprost acid-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Consensusnk2_onOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Consensusprostanoid_onOrthosteric Ligandtp_on fp-alpha_on
21.43Consensusprostanoid_on_gpOrthosteric Ligandtp_on_gp fp-alpha_on_gp
21.43Consensustp_onOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
21.43Consensustp_on_gpOrthosteric Ligand8XJO-TXA2-U46619-chim(NtGi1-Gs-CtGq)/β1/γ2
21.21Single7F6IKallidin7F6I-BK2-Kallidin-Gq/β1/γ2
21.21Single7LLYOxyntomodulin7LLY-GLP-1-Oxyntomodulin-Gs/β1/γ2
21.21Single7WBJPACAP277WBJ-VPAC1-PACAP27-Gs/β1/γ2
21.21Single7XV3Lysophosphatidylserine7XV3-GPR174-Lysophosphatidylserine-chim(NtGi1-Gs)/β1/γ2
21.21Single8E3ZVIP8E3Z-VPAC1-VIP-Gs/β1/γ2
21.21Single8WWMMCH8WWM-MCH1-MCH-Gi1/β1/γ2
21.21Single8XVIEndothelin-18XVI-ETA-Endothelin-1-chim(Gs-CtGq)/β1/γ2
21.21Consensusgi_apelinOrthosteric Ligand8XZH-Apelin-MM07-Gi1/β1/γ2 7W0M-Apelin-PubChem 122701908-Gi1/β1/γ2 8XZJ-Apelin-WN353-Gi1/β1/γ2 8XZF-Apelin-WN561-Gi1/β1/γ2 8XZG-Apelin-Apelin-13-Gi1/β1/γ2
21.21Consensusp2y10_onOrthosteric Ligand8KGG-P2Y10-LPS-chim(NtGi2-G13)/β1/γ2
21.05Single7VVMPTH7VVM-PTH1-PTH-Gs/β1/γ2
21.05Single8WCBCyclohexylammonium Ion8WCB-TA1-Cyclohexylammonium Ion-chim(NtGi1-Gs-CtGq)/β1/γ2
21.05Single8WCCCyclohexylammonium Ion8WCC-TA1-Cyclohexylammonium Ion
21.05Single9JR2PTH9JR2-PTH1-PTH-chim(NtGi1L-Gs-CtGq)/β1/γ2
21.05Consensuspth1_on_gpOrthosteric Ligand6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2 8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2 8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2 7Y36-PTH1-Teriparatide-Gs/β1/γ2 7Y35-PTH1-Abaloparatide-Gs/β1/γ2
20.83Single6FFIMMPEP6FFI-mGlu5-MMPEP
20.83Single6FK8PubChem 1324730356FK8-Rhodopsin-PubChem 132473035
20.83Single6FKAPubChem 1324730376FKA-Rhodopsin-PubChem 132473037
20.83Single6ZFZ77-LH-28-16ZFZ-M1-77-LH-28-1
20.83Single7XOVSR1461317XOV-CCKA-SR146131-Gs/β1/γ2
20.83Single8HQN9-S-HODE8HQN-GPR132-9-S-HODE-Gi1/β1/γ2
20.83Single8K4NVF08K4N-GPR34-VF0-Gi1/β1/γ2
20.83Single9BA0A1AKN9BA0-CB1-A1AKN
20.83Single9JFUNE52-QQ579JFU-GPR4-NE52-QQ57
20.83Single9JH3CMF-0199JH3-Apelin-CMF-019-Gi1/β1/γ2
20.83Single9K1DButanoic acid9K1D-FFA2-Butanoic acid-Gi1/β1/γ2
20.83Consensusat1_offOrthosteric Ligand4YAY-AT1-ZD-7155 4ZUD-AT1-Olmesartan
20.69Single5VBLApelin mimetic peptide agonist5VBL-Apelin-Apelin mimetic peptide agonist
20.69Single6OMMWKYMVX6OMM-FPR2-ALX-WKYMVX-Gi1/β1/γ2
20.69Single6RZ6ONO-25703666RZ6-CysLT2-ONO-2570366
20.69Single7AUESetmelanotide7AUE-MC4-Setmelanotide-chim(NtGi1L-Gs)/β1/γ2
20.69Single7F2OBradykinin7F2O-BK2-Bradykinin-chim(NtGi1-Gs-CtGq)/β1/γ2
20.69Single7RKNFractalkine7RKN-US28-Fractalkine-Gi1/β1/γ2
20.69Single7YAEOctreotide7YAE-SST2-Octreotide-Gi1/β1/γ2
20.69Single8J22TUG-13758J22-FFA2-TUG-1375-Gi1/β1/γ2
20.69Single8SAI1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine8SAI-GPR34-1-Oleoyl-2-Hydroxy-Sn-Glycero-3-Phospho-L-Serine-Gi1/β1/γ2
20.69Single8XQLCholesterol8XQL-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
20.69Single8XQOCholesterol8XQO-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
20.69Single9NS9TUG-13759NS9-FFA2-TUG-1375-Compound 187-Gi1/β1/γ2
20.69Consensuscxcr4_offOrthosteric Ligand4RWS-CXCR4-vMIP-II 3OE0-CXCR4-CVX15 3OE6-CXCR4-IT1t
20.69Consensuscxcr_on_gpOrthosteric Ligandcxcr3_on_gp cxcr4_on_gp cxcr1_on_gp cxcr2_on_gp
20.69Consensusgq_cckOrthosteric Ligand8IA7-CCKB-Cholecystokinin-8-chim(NtGi1L-Gq)/β1/γ2 7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2 7EZM-CCKA-Cholecystokinin-8-chim(NtGsL-Gq)/β1/γ2 7F8W-CCKB-Gastrin-17-chim(NtGsL-Gq)/β1/γ2
20.69Consensussst2_onOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
20.69Consensussst2_on_gpOrthosteric Ligand7WIC-SST2-Somatostatin-14-Gi1/β1/γ2 7WIG-SST2-L-054,264-Gi1/β1/γ2 7YAE-SST2-Octreotide-Gi1/β1/γ2 7YAC-SST2-Paltusotine-Gi1/β1/γ2
20.59Single4XT3Fractalkine4XT3-US28-Fractalkine
20.59Single5UIW5P7-CCL55UIW-CCR5-5P7-CCL5
20.59Single6FJ3PTH6FJ3-PTH1-PTH
20.59Single6NBFLong-Acting PTH Analog6NBF-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
20.59Single7KI0Semaglutide7KI0-GLP-1-Semaglutide-Gs/β1/γ2
20.59Single7SK4CXCL12_LRHQ7SK4-ACKR3-CXCL12_LRHQ
20.59Single7VABNon-Acylated Tirzepatide7VAB-GIP-Non-Acylated Tirzepatide-chim(NtGi1-Gs)/β1/γ2
20.59Single8JISPeptide-158JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2
20.59Single9BLWCagrilintide backbone (non-acylated)9BLW-CT (AMY1)-Cagrilintide backbone (non-acylated)-Gs/β1/γ2; RAMP1
20.59Consensusccr5_offOrthosteric Ligand5UIW-CCR5-5P7-CCL5
20.59Consensusccr5_onOrthosteric Ligand7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
20.00Single3PXOAll-trans-Retinal3PXO-Rhodopsin-All-trans-Retinal
20.00Single4QIMANTA XV4QIM-SMO-ANTA XV
20.00Single5DYSAll-trans-Retinal5DYS-Rhodopsin-All-trans-Retinal
20.00Single5MZJTheophylline5MZJ-A2A-Theophylline-Na
20.00Single5NDDAZ8838; Na5NDD-PAR2-AZ8838; Na
20.00Single6FFHFenobam6FFH-mGlu5-Fenobam
20.00Single6FK7PubChem 1324730346FK7-Rhodopsin-PubChem 132473034
20.00Single6FKCPubChem 1324730396FKC-Rhodopsin-PubChem 132473039
20.00Single6FKDPubChem 1373491836FKD-Rhodopsin-PubChem 137349183
20.00Single6GPSMK08126GPS-CCR2-MK0812
20.00Single6IIVDaltroban6IIV-TXA2-Daltroban
20.00Single6UVAAdrenomedullin-26UVA-CT Like (AM2)-Adrenomedullin-2-Gs/β1/γ2; RAMP3
20.00Single7VH0Ramelteon7VH0-MT2-Ramelteon-Gi1/β1/γ1
20.00Single7W53Neuromedin-U-257W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Single7WC4Serotonin7WC4-5-HT2A-Serotonin
20.00Single7WICSomatostatin-147WIC-SST2-Somatostatin-14-Gi1/β1/γ2
20.00Single7XMRSomatostatin-147XMR-SST2-Somatostatin-14-Gi1/β1/γ2
20.00Single8EJKTAK-8758EJK-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
20.00Single8HAOPTH8HAO-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
20.00Single8INRAlpha-MSH8INR-MC5-α-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
20.00Single8KEXDCA-3P8KEX-MRGPRX4-DCA-3P
20.00Single8PWNTheophylline8PWN-A2A-Theophylline
20.00Single8U4OCXCL128U4O-CXCR4-CXCL12-Gi1/β1/γ2
20.00Single8XGMChemerin8XGM-CML2-Chemerin-Gi1/β1/γ2
20.00Single8YH5Riboprine8YH5-A3A-Riboprine-Gi1/β1/γ2
20.00Single8ZJGChemerin8ZJG-CML1-Chemerin-Gi1/β1/γ2
20.00Single9BUCCagrilintide9BUC-CT-Cagrilintide-Gs/β1/γ2
20.00Single9HB3Mambaquaretin-19HB3-V2-Mambaquaretin-1
20.00Single9IYAONO-97105319IYA-GPR55-ONO-9710531
20.00Consensusalicarboxylic_offOrthosteric Ligandsuccinate_off
20.00Consensusccr2_offOrthosteric Ligand6GPS-CCR2-MK0812
20.00Consensusclass-b1_on_gpOrthosteric Ligandglucagon_on_gp vip-pacap_on_gp pth_on_gp crf_on_gp calcitonin_on_gp
20.00Consensusglucagon_on_gpOrthosteric Ligandglp_on_gp gluc_on_gp secretin_on_gp gip_on_gp
20.00Consensusnmur1_on_gpOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
20.00Consensusnucleotide_offonOrthosteric Ligandnucleotide_off nucleotide_on
20.00Consensusnucleotide_offon_gpOrthosteric Ligandnucleotide_on_gp nucleotide_off
20.00Consensussuccinate_offOrthosteric Ligand6RNK-Succinate-NF-56-EJ40 6Z10-Succinate-PubChem 154585554
19.44Single6UUSAdrenomedullin6UUS-CT Like (AM2)-Adrenomedullin-Gs/β1/γ2; RAMP3
19.44Single6WZGSecretin6WZG-Secretin-Secretin-Gs/β1/γ2
19.44Single7KI1Taspoglutide7KI1-GLP-1-Taspoglutide-Gs/β1/γ2
19.44Single7TYLAmylin7TYL-CT-Amylin-Gs/β1/γ2
19.44Single7VVJPTHrP(1-36)7VVJ-PTH1-PTHrP(1-36)-Gs/β1/γ2
19.44Single8FLTM-PTH(1-14)8FLT-PTH1-M-PTH(1-14)-Gs/β1/γ2
19.44Single9BYOExendin-39BYO-GLP-1-Exendin-3-Gs/β1/γ2
19.35Single7C6A(Sar1,Ile8)-Angiotensin II7C6A-AT2-(Sar1,Ile8)-Angiotensin II
19.35Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
19.35Single8JZZC5a-desArg8JZZ-C5a1-C5a-desArg-Go/β1/γ2
19.35Single8KH5Lysophosphatidylserine8KH5-GPR174-Lysophosphatidylserine-Gs/β1/γ2
19.35Single8WSSPro-MCH8WSS-MCH1-Pro-MCH-Gi1/β1/γ1
19.35Single9EAINanobody AT2099EAI-AT1-Losartan-Nanobody AT209
19.35Single9IQRMuscarinic toxin 39IQR-α2a-Muscarinic toxin 3
19.35Single9IQSMuscarinic toxin 39IQS-M4-Muscarinic toxin 3
19.23Single4PHUFasiglifam4PHU-FFA1-Fasiglifam
19.23Single5YHLPubChem 1351213525YHL-EP4-PubChem 135121352
19.23Single5YWYONO-AE3-2085YWY-EP4-ONO-AE3-208
19.23Single5ZBQUR-MK-2995ZBQ-Y1-UR-MK-299
19.23Single6GPXMK08126GPX-CCR2-MK0812
19.23Single6XBKCholesterol6XBK-SMO-Cholesterol-Gi1/β1/γ2
19.23Single7VV0PAMP-127VV0-MRGPRX2-PAMP-12
19.23Single8EJCTAK-8758EJC-FFA1-TAK-875-chim(NtGi1L-Gs-CtGq)/β1/γ2
19.23Single8GDCPGE28GDC-EP3-PGE2-Gi1/β1/γ2
19.23Single8IZ4Lysophosphatidylserine8IZ4-GPR34-Lysophosphatidylserine-Gi1/β1/γ2
19.23Single8TH4Losartan8TH4-AT1-Losartan-AT118-L Nanobody
19.23Single8ZVZBW245C8ZVZ-DP1-BW245C-Gs/β1/γ2
19.23Single9EAHOlmesartan9EAH-AT1-Olmesartan-Nanobody AT209
19.23Single9HC04YI9HC0-mGlu5-4YI
19.23Consensuscyslt_offOrthosteric Ligandcyslt2_off cyslt1_off
19.23Consensusep4_offOrthosteric Ligand5YWY-EP4-ONO-AE3-208 5YHL-EP4-PubChem 135121352
19.23Consensusep_offOrthosteric Ligandep4_off
19.05Single3OE8IT1t3OE8-CXCR4-IT1t
19.05Single3RFMCaffeine3RFM-A2A-Caffeine
19.05Single6OT025(S)-Epoxycholesterol6OT0-SMO-25(S)-Epoxycholesterol-Gi1/β1/γ2
19.05Single6TQ9SB-4081246TQ9-OX1-SB-408124
19.05Single8A2OTheophylline8A2O-A2A-Theophylline-Na
19.05Single8GEIConstrained Epinephrine8GEI-β2-Constrained Epinephrine-Gs/β1/γ2
19.05Single8XOFLys058XOF-GPR30-Lys05-chim(NtGi1-Gs-CtGq)/β1/γ2
19.05Single9C2FCa; Ca; Tryptophan; '54149; PO49C2F-CaS-Ca-Ca; Ca; Tryptophan; '54149; PO4
19.05Consensusclass-b1_onOrthosteric Ligandglucagon_on vip-pacap_on pth_on crf_on calcitonin_on
19.05Consensusopsins_onOrthosteric Ligandrhodopsin_on opsin1lw_on
19.05Consensussensory_onOrthosteric Ligandopsins_on
18.75Single3OE0CVX153OE0-CXCR4-CVX15
18.75Single6UUNAdrenomedullin6UUN-CT Like (AM1)-Adrenomedullin-Gs/β1/γ2; RAMP2
18.75Single6VN7PACAP6VN7-VPAC1-PACAP-Gs/β1/γ2
18.75Single8XZGApelin-138XZG-Apelin-Apelin-13-Gi1/β1/γ2
18.75Single8XZHMM078XZH-Apelin-MM07-Gi1/β1/γ2
18.75Single9IVMGLP-1 (Truncated)9IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
18.75Consensusmc3_onOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
18.75Consensusmc3_on_gpOrthosteric Ligand8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
18.52Single4OO9Mavoglurant4OO9-mGlu5-Mavoglurant
18.52Single5TZRMK86665TZR-FFA1-MK8666
18.52Single5V56TC1145V56-SMO-TC114
18.52Single6Z8NSRI-98296Z8N-NTS1-SRI-9829
18.52Single7R0CAVP7R0C-V2-AVP-Arrestin2
18.52Single7T9NDPPC7T9N-TSH-M22 Fab-DPPC-Gs/β1/γ2
18.52Single7XWONeurokinin-A7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Single8FMZNeurotensin/Neuromedin-N8FMZ-NTS1-Neurotensin/Neuromedin-N-chim(NtGi2L-Gs-CtGq)/β1/γ2
18.52Single8I2GCompound 7163408I2G-FSH-Glycoprotein hormones α chain-Compound 716340-Gs/β1/γ2
18.52Single8IUKPGF2-alpha8IUK-FP-alpha-PGF2-α-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Single8JBGNeurokinin-B8JBG-NK3-Neurokinin-B-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Single8JZPC5A anaphylatoxin8JZP-C5a1-C5A anaphylatoxin-Go/β1/γ2
18.52Single8TAOCDPPB8TAO-mGlu5; mGlu5-Quisqualate-CDPPB
18.52Single8XIPPasireotide8XIP-SST1-Pasireotide-chim(NtGi1-Gs-CtGi1)/β1/γ2
18.52Single8XQTCholesterol8XQT-TAS2R14-Cholesterol-Gi1/β1/γ1
18.52Single8ZR5Firuglipel8ZR5-GPR119-Firuglipel-Gs/β1/γ2
18.52Single8ZW0PGD28ZW0-DP1-PGD2-Gs/β1/γ2
18.52Single9CLWTUG-13759CLW-FFA2-TUG-1375-4-CMTB-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.52Consensusffa2_onOrthosteric Ligand8J22-FFA2-TUG-1375-Gi1/β1/γ2
18.52Consensusnk2_on_gpOrthosteric Ligand7XWO-NK2-Neurokinin-A-chim(NtGi1-Gs-CtGq)/β1/γ2
18.52Consensusnpy1_offOrthosteric Ligand5ZBH-Y1-BMS-193885 5ZBQ-Y1-UR-MK-299
18.52Consensusp2y12_onOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
18.52Consensusprotein_offOrthosteric Ligandchemokine_off grh_off
18.42Single7SK6CXCL12_LRHQ7SK6-ACKR3-CXCL12_LRHQ
18.42Single8F2APramlintide Analogue San3858F2A-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
18.18Single3PQRAll-trans-Retinal3PQR-Rhodopsin-All-trans-Retinal-Gt(CT)
18.18Single6FK9PubChem 1324730366FK9-Rhodopsin-PubChem 132473036
18.18Single6FUFAll-trans-Retinal6FUF-Rhodopsin-All-trans-Retinal-Go
18.18Single6M1IPACAP6M1I-PAC1-PACAP-Gs/β1/γ2
18.18Single6ME5Agomelatine6ME5-MT1-Agomelatine
18.18Single7D77Hydrocortisone7D77-ADGRG3-Hydrocortisone-Go/β1/γ2
18.18Single7MT9All-trans-Retinal7MT9-Rhodopsin-All-trans-Retinal-GRK1
18.18Single7MTAAll-trans-Retinal7MTA-Rhodopsin-All-trans-Retinal-GRK1
18.18Single7W57Neuromedin-S7W57-NMUR2-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
18.18Single8EITDoconexent8EIT-FFA1-Doconexent-chim(NtGi1L-Gs-CtGq)/β1/γ2
18.18Single8IU2Retinal8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
18.18Single8X9UMetenolone8X9U-ADGRD1-Metenolone-chim(NtGi1-Gs)/β1/γ2
18.18Single8XZJWN3538XZJ-Apelin-WN353-Gi1/β1/γ2
18.18Single8Y63C20:0 Ceramide8Y63-FPR2-ALX-C20:0 Ceramide-Gi1/β1/γ2
18.18Single8YW4Retatrutide8YW4-GIP-Retatrutide-chim(NtGi1-Gs)/β1/γ2
18.18Single9EBOGLP-1 (ACPC18)9EBO-GLP-1-GLP-1 (ACPC18)-Gs/β1/γ2
18.18Single9JHJC18:0 Ceramide9JHJ-FPR2-ALX-C18:0 Ceramide-Gi1/β1/γ2
18.18Consensuscrf2_onOrthosteric Ligand7TS0-CRF2-Urocortin-chim(NtGi1L-Go)/β1/γ2
18.18Consensusgi_opsinsOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
18.18Consensusgi_sensoryOrthosteric Ligandgi_opsins
18.18Consensusopsin1lw_onOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
18.18Consensusopsin1lw_on_gpOrthosteric Ligand8IU2-Opsin1LW-Retinal-Gi1/β1/γ2
18.18Consensusopsins_on_gpOrthosteric Ligandrhodopsin_on_gp opsin1lw_on_gp
18.18Consensusprotein_offonOrthosteric Ligandprotein_off protein_on
18.18Consensusprotein_offon_gpOrthosteric Ligandprotein_on_gp protein_off
18.18Consensusrhodopsin_onOrthosteric Ligand6OYA-Rhodopsin-All-trans-Retinal-Gt/β1/γ1
18.18Consensussensory_on_gpOrthosteric Ligandopsins_on_gp
17.95Single6WPWGlucagon derivative ZP37806WPW-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
17.86Single6AK3Dinoprostone IPGE26AK3-EP3-Dinoprostone IPGE2
17.86Single6IIURamatroban6IIU-TXA2-Ramatroban
17.86Single7W0NElabela7W0N-Apelin-Elabela-Gi1/β1/γ2
17.86Single7XW5ML1097XW5-TSH-TSH-ML109-Gs/β1/γ2
17.86Single7XXI2MeSADP7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
17.86Single7XZ5Lysophosphatidylcholine7XZ5-GPR119-Lysophosphatidylcholine-Gs/β1/γ2
17.86Single8GCPPGE28GCP-EP4-PGE2-Gi1/β1/γ2
17.86Single8HK2C3a anaphylatoxin8HK2-C3aB-C3a anaphylatoxin-Gi1/β1/γ2
17.86Single8JJPChemerin8JJP-CML2-Chemerin-Gi1/β1/γ2
17.86Single8JPBNeurotensin-(8-13)8JPB-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
17.86Single8XQNCholesterol8XQN-TAS2R14-Cholesterol-Aristolochic acid A-Gi1/β1/γ1
17.86Single9AU0BW245C9AU0-DP1-BW245C-Gs/β1/γ2
17.86Single9CM3TUG-13759CM3-FFA2-TUG-1375-Compound 187-chim(NtGi1L-Gs-CtGq)/β1/γ2
17.86Consensuscxcr_onOrthosteric Ligandcxcr3_on cxcr4_on cxcr1_on cxcr2_on
17.86Consensusgi_p2yOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
17.86Consensusp2y12_on_gpOrthosteric Ligand7XXI-P2Y12-2MeSADP-Gi2/β1/γ2
17.65Single6X18GLP-16X18-GLP-1-GLP-1-Gs/β1/γ2
17.65Single7VL9CCL15(26-92)7VL9-CCR1-CCL15(26-92)-Gi1/β1/γ2
17.65Single8E3YPACAP278E3Y-VPAC1-PACAP27-Gs/β1/γ2
17.65Consensuschemokine_offOrthosteric Ligandccr_off cxcr_off
17.65Consensuschemokine_on_gpOrthosteric Ligandccr_on_gp cxcr_on_gp
17.65Consensuscxcr_offOrthosteric Ligandcxcr3_off cxcr4_off
17.65Consensusgi_chemokineOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2 8HNK-CXCR3-CXCL11-Gi1/β1/γ2 8K3Z-CXCR4-CXCL12-Gi1/β1/γ1 8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2 6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2 8KFX-CCR8-LMD-009-Gi1/β1/γ2 7F1Q-CCR5-MIP-1a-Gi1/β1/γ2 8HNL-CXCR3-PS372424-Gi1/β1/γ2 8KFY-CCR8-ZK-756326-Gi1/β1/γ2 7O7F-CCR5-6P4-CCL5-Gi1/β1/γ1 8U1U-CCR8-CCL1-Gi1/β1/γ2 7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2 7XA3-CCR2-CCL2-Gi1/β1/γ2
17.65Consensusvpac1_onOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
17.50Consensusglucagon_onOrthosteric Ligandglp_on gluc_on secretin_on gip_on
17.39Single6FK6PubChem 1324730336FK6-Rhodopsin-PubChem 132473033
17.39Single6LI0C176LI0-GPR52-C17
17.39Single8X2KOleic monoethanolamide8X2K-GPR3-Oleic monoethanolamide-chim(NtGi1-Gs)/β1/γ2
17.39Single8ZX5AM2518ZX5-GPR55-AM251-chim(NtGi1-G13)/β1/γ2
17.39Single9LMPNE52-QQ579LMP-GPR4-NE52-QQ57
17.39Consensusadgrg_onOrthosteric Ligandadgrg2_on adgrg4_on
17.39Consensusadgrg_on_gpOrthosteric Ligandadgrg2_on_gp adgrg4_on_gp
17.24Single4RWSvMIP-II4RWS-CXCR4-vMIP-II
17.24Single7LLLExendin-47LLL-GLP-1-Exendin-4-Gs/β1/γ2
17.24Single7VVNPTH7VVN-PTH1-PTH-Gs/β1/γ2
17.24Single8HN1Toxin AdTx18HN1-Alpha1A-Toxin AdTx1
17.24Single8JPFNeurotensin8JPF-NTS1-Neurotensin-SBI-553
17.24Single8K2XCXCL108K2X-CXCR3-CXCL10-Gi1/β1/γ2
17.24Single8ZPLHF511168ZPL-CXCR4-HF51116
17.24Single8ZX4Lysophosphatidylinositol 8ZX4-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
17.24Single9GE3Lysophosphatidylinositol9GE3-GPR55-Lysophosphatidylinositol-chim(NtGi1-G13)/β1/γ2
17.24Single9GG5U466199GG5-TXA2-U46619-chim(NtGi2L-Gs-CtGq)/β1/γ2
17.14Single6P9YPACAP6P9Y-PAC1-PACAP-Gs/β1/γ2
17.14Single7CZ5Somatoliberin7CZ5-GHRH-Somatoliberin-Gs/β1/γ2
17.14Single7D3SSecretin7D3S-Secretin-Secretin-Gs/β1/γ2
17.14Single7RA3GIP7RA3-GIP-GIP-chim(NtGi1-Gs)/β1/γ2
17.14Single8E3XPACAP278E3X-PAC1-PACAP27-Gs/β1/γ2
17.14Single9J1Pg1:Ox9J1P-GLP-1-g1:Ox-chim(NtGi1-Gs)/β1/γ2
17.14Consensusccr_offOrthosteric Ligandccr2_off ccr5_off
17.14Consensuspac_on_gpOrthosteric Ligandpac1_on_gp
17.14Consensussecretin_onOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
17.14Consensusvpac1_on_gpOrthosteric Ligand8E3Z-VPAC1-VIP-Gs/β1/γ2
17.07Single6E3YCalcitonin gene-related peptide-16E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
16.67Single5NX2GLP-1 (Truncated)5NX2-GLP-1-GLP-1 (Truncated)
16.67Single6VCBGLP-16VCB-GLP-1-GLP-1-LSN3160440-Gs/β1/γ2
16.67Single7BR3Elagolix7BR3-GnRH1-Elagolix
16.67Single7DTYGIP7DTY-GIP-GIP-Gs/β1/γ2
16.67Single7F8YDevazepide7F8Y-CCKA-Devazepide
16.67Single7FIYTirzepatide7FIY-GIP-Tirzepatide-Gs/β1/γ2
16.67Single7S1MEx4-D-Ala7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2
16.67Single7S8PMS471347S8P-MRGPRX4-MS47134-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single7TYFAmylin7TYF-CT (AMY1)-Amylin-Gs/β1/γ2; RAMP1
16.67Single7VQXPACAP277VQX-VPAC1-PACAP27-Gs/β1/γ2
16.67Single7W0OElabela7W0O-Apelin-Elabela-Gi1/β1/γ2
16.67Single7X2CFenoldopam7X2C-D1-Fenoldopam-Fenoldopam-Gs/β1/γ2
16.67Single7X8SWB4-247X8S-GLP-1-WB4-24-Gs/β1/γ2
16.67Single8DWHPubChem 1390305318DWH-MRGPRX1-PubChem 139030531-chim(NtGi2L-Gs-CtGq)/β1/γ2
16.67Single8FU6Glucagon derivative ZP37808FU6-Glucagon-Glucagon derivative ZP3780-Gs/β1/γ2
16.67Single8GDAL9026888GDA-EP4-L902688-Gs/β1/γ2
16.67Single8HMPC178HMP-GPR52-C17-Gs/β1/γ2
16.67Single8IQ4Carboprost8IQ4-FP-alpha-Carboprost-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Single8XXVIndomethacin8XXV-DP2-Indomethacin-A1D5Q-Gi1/β1/γ2
16.67Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
16.67Single9CM7TUG-13759CM7-FFA2-TUG-1375-AZ-1729-Gi1/β1/γ2
16.67Consensusangiotensin_offOrthosteric Ligandat1_off
16.67Consensusgnrh1_offOrthosteric Ligand7BR3-GnRH1-Elagolix
16.67Consensusnmur1_onOrthosteric Ligand7W53-NMUR1-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
16.67Consensussecretin_on_gpOrthosteric Ligand7D3S-Secretin-Secretin-Gs/β1/γ2
16.22Single6LMLGlucagon6LML-Glucagon-Glucagon-Gi1/β1/γ1
16.22Single7VVLPTH7VVL-PTH1-PTH-Gs/β1/γ2
16.22Single8F0KPramlintide Analogue San3858F0K-CT (AMY3)-Pramlintide Analogue San385-Gs/β1/γ2; RAMP3
16.22Single8HAFPTHrP(1-36)8HAF-PTH1-PTHrP(1-36)-chim(NtGi1-Gs)/β1/γ2
16.22Consensusvip-pacap_onOrthosteric Ligandvpac_on pac_on
16.22Consensusvip-pacap_on_gpOrthosteric Ligandvpac_on_gp pac_on_gp
16.13Single6X19CHU-1286X19-GLP-1-CHU-128-Gs/β1/γ2
16.13Single7L0RNeurotensin7L0R-NTS1-Neurotensin-Gi1/β1/γ1
16.13Single7W56Neuromedin-S7W56-NMUR1-Neuromedin-S-chim(NtGi1-Gs-CtGq)/β1/γ2
16.13Single8YWFRetatrutide8YWF-GLP-1-Retatrutide-chim(NtGi1-Gs)/β1/γ2
16.13Single9L3YRetinoic acid receptor responder protein 29L3Y-CML2-Retinoic acid receptor responder protein 2-Gi1/β1/γ2
16.00Single4ZUDOlmesartan4ZUD-AT1-Olmesartan
16.00Single7UTZDPPC7UTZ-TSH-TR1402-DPPC-Gs/β1/γ2
16.00Single7XXH2MeSADP7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
16.00Single8K4SDCA-3P8K4S-MRGPRX4-DCA-3P-chim(NtGi1L-Gs-CtGq)/β1/γ2
16.00Single8X7ATreprostinil8X7A-I2-Treprostinil-Gs/β1/γ2
16.00Single8ZPNAMD31008ZPN-CXCR4-AMD3100
16.00Single9DQJEP-39459DQJ-MRGPRD-EP-3945-chim(NtGi1-Gs-CtGq)/β1/γ2
16.00Consensusgrh_offOrthosteric Ligandgnrh1_off
16.00Consensusnucleotide_offOrthosteric Ligandadenosine_off p2y_off
16.00Consensusp2y1_on_gpOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
15.91Single8F0JPramlintide Analogue San458F0J-CT-Pramlintide Analogue San45-Gs/β1/γ2
15.79Single7RBTTirzepatide7RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
15.79Single7TYXAmylin7TYX-CT (AMY2)-Amylin-Gs/β1/γ2; RAMP2
15.79Consensusgip_onOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
15.79Consensusgip_on_gpOrthosteric Ligand7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2 7FIY-GIP-Tirzepatide-Gs/β1/γ2 7DTY-GIP-GIP-Gs/β1/γ2
15.62Single7E14Orforglipron7E14-GLP-1-Orforglipron-PubChem 156022738-Gs/β1/γ2
15.62Single7F1QMIP-1a7F1Q-CCR5-MIP-1a-Gi1/β1/γ2
15.62Single7VBINon-Acylated Tirzepatide7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
15.62Single7XNACYN1548067XNA-SST2-CYN154806
15.62Single8IBVMotilin8IBV-Motilin-Motilin-chim(NtGi1-Gs-CtGq)/β1/γ2
15.62Single8IOCGamma-MSH8IOC-MC3-γ-MSH-Ca-chim(NtGi1-Gs)/β1/γ2
15.62Single8K6OPro-neuropeptide-Y8K6O-Y1-Pro-neuropeptide-Y-Gi2/β1/γ1
15.62Single8Z7JAgonistic antibody8Z7J-Apelin-Agonistic antibody-Gi1/β1/γ2
15.62Consensussst2_offOrthosteric Ligand7XNA-SST2-CYN154806
15.38Single6ORVTT-OAD26ORV-GLP-1-TT-OAD2-Gs/β1/γ2
15.38Single6Z4VNTS8-136Z4V-NTS1-NTS8-13
15.38Single7FIHOrg435537FIH-LH-hCG-Org43553-chim(NtGi1-Gs)/β1/γ2
15.38Single7TRQVU04671547TRQ-M4-Iperoxo-VU0467154-Gi1/β1/γ2
15.38Single7TZFAmylin7TZF-CT (AMY3)-Amylin-Gs/β1/γ2; RAMP3
15.38Single7VBHPeptide-207VBH-GLP-1-Peptide-20-Gs/β1/γ2
15.38Single7WQ3Galanin7WQ3-GAL1-Galanin-Gi1/β1/γ2
15.38Single8GCML9026888GCM-EP4-L902688-Gi1/β1/γ2
15.38Single8XBGS3E-LysoPS8XBG-GPR34-S3E-LysoPS
15.38Single8XJLPGF2-alpha8XJL-FP-alpha-PGF2-α-chim(NtGi2-Gs-CtGq)/β1/γ2
15.38Consensusgal1_onOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
15.38Consensusgal1_on_gpOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
15.38Consensusgi_galaninOrthosteric Ligand7WQ3-GAL1-Galanin-Gi1/β1/γ2
15.15Single7W55Neuromedin-U-257W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
15.15Single7XA3CCL27XA3-CCR2-CCL2-Gi1/β1/γ2
15.15Single9B5YLong-Acting PTH9B5Y-PTH1-Long-Acting PTH-chim(NtGi1-Gq)/β1/γ2
15.15Consensusccr2_onOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
15.15Consensusccr2_on_gpOrthosteric Ligand7XA3-CCR2-CCL2-Gi1/β1/γ2
15.15Consensusccr_onOrthosteric Ligandccr6_on ccr8_on ccr2_on ccr1_on ccr5_on
15.15Consensusnmur2_onOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
15.15Consensusnmur2_on_gpOrthosteric Ligand7W55-NMUR2-Neuromedin-U-25-chim(NtGi1-Gs-CtGq)/β1/γ2
15.00Single4A4MAll-trans-Retinal4A4M-Rhodopsin-All-trans-Retinal-Gt(CT)
15.00Single5EN0All-trans-Retinal5EN0-Rhodopsin-All-trans-Retinal-Gt(CT)
15.00Single5MZPCaffeine5MZP-A2A-Caffeine-Na
15.00Single8GEJConstrained Epinephrine8GEJ-β2-Constrained Epinephrine-Gs/β1/γ2
15.00Single8JIPMEDI03828JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2
15.00Single8JIRSAR4258998JIR-GLP-1-SAR425899-chim(NtGi1-Gs)/β1/γ2
15.00Consensusglp1_on_gpOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
14.81Single4JKVTaladegib4JKV-SMO-Taladegib
14.81Single5T1ABMS-6815T1A-CCR2-BMS-681-PubChem 12093170
14.81Single6M9TMisoprostol-FA6M9T-EP3-Misoprostol-FA
14.81Single7BB7AVP7BB7-V2-AVP-Gs/β1/γ2
14.81Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
14.81Single8GD9Rivenprost8GD9-EP4-Rivenprost-Gs/β1/γ2
14.81Single9DQHEP-28259DQH-MRGPRD-EP-2825-chim(NtGi1-Gs-CtGq)/β1/γ2
14.81Consensusadgrg2_onOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
14.81Consensusadgrg2_on_gpOrthosteric Ligand7WUI-ADGRG2-IP15-chim(NtGi1-Gs)/β1/γ2 7WUQ-ADGRG2-Gs/β1/γ2 7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
14.71Single6NIYAdrenomedullin6NIY-CT-Adrenomedullin-Gs/β1/γ2
14.71Single7FINPeptide-20; GGL7FIN-GIP-Peptide-20; GGL-Gs/β1/γ2
14.71Single7TYIAmylin7TYI-CT-Amylin-Gs/β1/γ2
14.63Single7TYOCalcitonin7TYO-CT-Calcitonin-Gs/β1/γ2
14.63Single7TYYCalcitonin-17TYY-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
14.29Single3ZEVNeurotensin3ZEV-NTS1-Neurotensin
14.29Single4BV0Neurotensin4BV0-NTS1-Neurotensin
14.29Single5V57TC1145V57-SMO-TC114
14.29Single5YQZGlucagon analogue5YQZ-Glucagon-Glucagon analogue
14.29Single5ZBHBMS-1938855ZBH-Y1-BMS-193885
14.29Single7L0PNeurotensin7L0P-NTS1-Neurotensin-Gi1/β1/γ1
14.29Single7L0QNeurotensin7L0Q-NTS1-Neurotensin-Gi1/β1/γ1
14.29Single7TYWCalcitonin-17TYW-CT (AMY1)-Calcitonin-1-Gs/β1/γ2; RAMP1
14.29Single7XBDGalanin7XBD-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
14.29Single7XOWGastrin7XOW-CCKB-Gastrin-chim(NtGi1-Gq)/β1/γ2
14.29Single8FN1Neurotensin/Neuromedin-N8FN1-NTS1-Neurotensin/Neuromedin-N-chim(NtGi1-Go)/β1/γ2
14.29Single8WJXADP8WJX-P2Y1-ADP-chim(Gs-CtGq)/β1/γ2
14.29Single9ITELPA9ITE-LPA6-LPA-chim(NtGi2-G13)/β1/γ2
14.29Single9IV25alpha-DHT9IV2-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
14.29Consensuscalcitonin_onOrthosteric Ligandctlike_on
14.29Consensusccr_on_gpOrthosteric Ligandccr6_on_gp ccr8_on_gp ccr2_on_gp ccr1_on_gp ccr5_on_gp
14.29Consensusneuromedin-u_on_gpOrthosteric Ligandnmur1_on_gp nmur2_on_gp
14.29Consensusneurotensin_onOrthosteric Ligandnts1_on
14.29Consensusnts1_onOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
14.29Consensuspac_onOrthosteric Ligandpac1_on
14.29Consensusvpac_onOrthosteric Ligandvpac1_on vpac2_on
13.89Single6NBILong-Acting PTH Analog6NBI-PTH1-Long-Acting PTH Analog-Gs/β1/γ2
13.89Single7SK3CXCL127SK3-ACKR3-CXCL12
13.89Single8FLRPTHrP(1-36)8FLR-PTH1-PTHrP(1-36)-Gs/β1/γ2
13.89Single9BLBCagrilintide backbone (non-acylated)9BLB-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
13.89Single9BP3Cagrilintide9BP3-CT (AMY1)-Cagrilintide-Gs/β1/γ2; RAMP1
13.89Consensuscalcitonin_on_gpOrthosteric Ligandctlike_on_gp
13.89Consensusctlike_onOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
13.89Consensuspac1_onOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
13.89Consensuspac1_on_gpOrthosteric Ligand8E3X-PAC1-PACAP27-Gs/β1/γ2 6M1H-PAC1-Maxadilan-Gs/β1/γ2
13.89Consensusvpac_on_gpOrthosteric Ligandvpac1_on_gp vpac2_on_gp
13.79Single3VW7Vorapaxar; Na3VW7-PAR1-Vorapaxar; Na
13.79Single4GRVNeurotensin-(8-13)4GRV-NTS1-Neurotensin-(8-13)
13.79Single4XEENeurotensin4XEE-NTS1-Neurotensin
13.79Single4XESNeurotensin4XES-NTS1-Neurotensin
13.79Single6OSAJMV4496OSA-NTS1-JMV449-Gi1/β1/γ2
13.79Single6XOXOrforglipron6XOX-GLP-1-Orforglipron-chim(NtGi1-Gs)/β1/γ2
13.79Single7L0SNeurotensin7L0S-NTS1-Neurotensin-Gi1/β1/γ1
13.79Single7WQ4Galanin7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2
13.79Single7XJKGalanin7XJK-GAL2-Galanin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.79Consensusgalanin_onOrthosteric Ligandgal2_on gal1_on
13.79Consensusgalanin_on_gpOrthosteric Ligandgal2_on_gp gal1_on_gp
13.79Consensusgi_neurotensinOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
13.79Consensusneurotensin_on_gpOrthosteric Ligandnts1_on_gp
13.79Consensusnts1_on_gpOrthosteric Ligand6OSA-NTS1-JMV449-Gi1/β1/γ2 7L0S-NTS1-Neurotensin-Gi1/β1/γ1
13.64Single2HPYAll-trans-Retinal2HPY-Rhodopsin-All-trans-Retinal
13.64Single7MTBAll-trans-Retinal7MTB-Rhodopsin-All-trans-Retinal-GRK1
13.64Single8Y02Retinal8Y02-OPN1SW-Retinal-Gi1/β1/γ2
13.64Single9EE9Adenosine9EE9-A2A-Adenosine-Gs/β1/γ2
13.51Single7TYNCalcitonin-17TYN-CT-Calcitonin-1-Gs/β1/γ2
13.51Single7VVKPTH7VVK-PTH1-PTH-Gs/β1/γ2
13.33Single4BUONeurotensin4BUO-NTS1-Neurotensin
13.33Single6UP7Neurotensin6UP7-NTS1-Neurotensin-Arrestin2
13.33Single8K4OCXCL18K4O-KSHV-CXCL1-Gi1/β1/γ1
13.33Single9C0KExendin-49C0K-GLP-1-Exendin-4-Gs/β1/γ2
13.33Single9M1HProstaglandin E29M1H-EP1-Prostaglandin E2-chim(NtGi1-Gs-CtGq)/β1/γ2
13.33Consensusgal2_onOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.33Consensusgal2_on_gpOrthosteric Ligand7WQ4-GAL2-Galanin-chim(NtGi1-Gs-CtGq)/β1/γ2 7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
13.16Single9BTWCagrilintide9BTW-CT (AMY3)-Cagrilintide-Gs/β1/γ2; RAMP3
13.16Consensusctlike_on_gpOrthosteric Ligand6E3Y-CT Like-Calcitonin gene-related peptide-1-Gs/β1/γ2; RAMP1
13.16Consensusvpac2_onOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
13.16Consensusvpac2_on_gpOrthosteric Ligand7VQX-VPAC1-PACAP27-Gs/β1/γ2
13.04Single2ZIY11-cis-Retinal2ZIY-Rhodopsin-11-cis-Retinal
13.04Single6OIKLY21196206OIK-M2-Iperoxo-LY2119620-chim(NtGi1-Go)/β1/γ2
13.04Single8F2BPramlintide Analogue San458F2B-CT (AMY3)-Pramlintide Analogue San45-Gs/β1/γ2; RAMP3
13.04Single8F76Propanoic acid8F76-OR51E2-Propanoic acid-Gs/β1/γ2
13.04Single8JEF(3S)-3-hydroxyoctanoic acid8JEF-HCA3-(3S)-3-hydroxyoctanoic acid-Gi1/β1/γ2
13.04Single8RQLFlufenamic acid8RQL-TAS2R14-Flufenamic acid-Flufenamic acid-chim(NtGi1-Gt3)/β1/γ2
12.90Single6OS9JMV4496OS9-NTS1-JMV449-Gi1/β1/γ2
12.90Single7CX2PGE27CX2-EP2-PGE2-Gs/β1/γ2
12.90Single8XX6CXCL88XX6-CXCR2-CXCL8-Go/β1/γ2
12.90Single8Z74Agonistic antibody8Z74-Apelin-Agonistic antibody
12.90Single9EAJNanobody AT2099EAJ-AT1-Nanobody AT209
12.90Single9ITBLPA9ITB-LPA6-LPA-chim(NtGi1-Gs-CtGq)/β1/γ2
12.50Single3AYMAll-trans-Retinal3AYM-Rhodopsin-All-trans-Retinal
12.50Single5L7IVismodegib5L7I-SMO-Vismodegib
12.50Single7RTBPeptide-197RTB-GLP-1-Peptide-19-Gs/β1/γ2
12.50Single7S8NR-Zinc-35737S8N-MRGPRX2-R-Zinc-3573-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single7S8OR-Zinc-35737S8O-MRGPRX2-R-Zinc-3573-Gi1/β1/γ2
12.50Single7T96LY21196207T96-M2-Acetylcholine-LY2119620-Go/β1/γ2
12.50Single7TRPLY20332987TRP-M4-Iperoxo-LY2033298-Gi1/β1/γ2
12.50Single7VDHC48/807VDH-MRGPRX2-C48/80-Gi1/β1/γ2
12.50Single7XKFBeta-Hydroxyandrosterone7XKF-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
12.50Single8DWGProenkephalin-A8DWG-MRGPRX1-Proenkephalin-A-ML382-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.50Single8FX5Xanomeline8FX5-M4-Xanomeline-Xanomeline-Gi1/β1/γ2
12.50Single8U4RREGN7663-Fab8U4R-CXCR4-REGN7663-Fab
12.50Single8XWNCXCL88XWN-CXCR2-CXCL8
12.50Single8ZYUNeurotensin peptide 8-138ZYU-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
12.50Single9BUECagrilintide9BUE-CT-Cagrilintide-Gs/β1/γ2
12.50Consensuschemokine_onOrthosteric Ligandccr_on cxcr_on
12.50Consensusglp1_onOrthosteric Ligand7S1M-GLP-1-Ex4-D-Ala-Gs/β1/γ2 7X8R-GLP-1-BOC5-Gs/β1/γ2 6X19-GLP-1-CHU-128-Gs/β1/γ2 6X1A-GLP-1-Danuglipron-Gs/β1/γ2 6X18-GLP-1-GLP-1-Gs/β1/γ2 8JIP-GLP-1-MEDI0382-chim(NtGi1-Gs)/β1/γ2 7C2E-GLP-1-PubChem 149050799-Gs/β1/γ2 7KI0-GLP-1-Semaglutide-Gs/β1/γ2 7KI1-GLP-1-Taspoglutide-Gs/β1/γ2 7X8S-GLP-1-WB4-24-Gs/β1/γ2 8JIS-GLP-1-Peptide-15-chim(NtGi1-Gs)/β1/γ2 7VBI-GLP-1-Non-Acylated Tirzepatide-Gs/β1/γ2
12.50Consensusgq_nucleotideOrthosteric Ligandgq_p2y
12.50Consensusgq_p2yOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
12.50Consensussomatostatin_offOrthosteric Ligandsst2_off
12.20Single7V35Peptide-207V35-Glucagon-Peptide-20-Gs/β1/γ2
12.12Single6WHCGlu16 analog of GCG6WHC-Glucagon-Glu16 analog of GCG-Gs/β1/γ2
12.12Single7TRYUrocortin7TRY-CRF2-Urocortin-chim(NtGi1-G11)/β1/γ2
12.00Single2Z7311-cis-Retinal2Z73-Rhodopsin-11-cis-Retinal
12.00Single3AYN9-cis-Retinal3AYN-Rhodopsin-9-cis-Retinal
12.00Single4MQTLY21196204MQT-M2-Iperoxo-LY2119620
12.00Single6LFOInterleukin-86LFO-CXCR2-Interleukin-8-Gi1/β1/γ2
12.00Single6ZA8RTI-3a6ZA8-NTS1-RTI-3a
12.00Single7LCJDanuglipron7LCJ-GLP-1-Danuglipron
12.00Single7VV5C48/807VV5-MRGPRX2-C48/80-Gi1/β1/γ2
12.00Single7VVOPTH7VVO-PTH1-PTH-Gs/β1/γ2
12.00Single7XJJGalanin7XJJ-GAL1-Galanin-Go/β1/γ2
12.00Single8T3VDocosa-4,7,10,13,16,19-Hexaenoic acid8T3V-FFA1-Docosa-4,7,10,13,16,19-Hexaenoic acid-chim(NtGi2L-Gs-CtGq)/β1/γ2
12.00Single8U4PAMD31008U4P-CXCR4-AMD3100-Gi1/β1/γ2
12.00Single8U8FPalmitic Acid8U8F-GPR3-Palmitic Acid-Gs/β1/γ2
12.00Consensusp2y1_onOrthosteric Ligand7XXH-P2Y1-2MeSADP-chim(NtGi1-G11)/β1/γ2
11.90Single8JIUSAR4258998JIU-Glucagon-SAR425899-Gs/β1/γ2
11.76Consensusclass-b1_class-b2_cons_onOrthosteric Ligandclass-b1_on class-b2_on
11.76Consensusclass-b1_class-b2_cons_on_gpOrthosteric Ligandclass-b1_on_gp class-b2_on_gp
11.63Consensusgluc_onOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
11.54Single6WJCMuscarinic toxin 76WJC-M1-Atropine-Muscarinic toxin 7
11.54Single7BB6AVP7BB6-V2-AVP-Gs/β1/γ2
11.54Single7M3GCa; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO47M3G-CaS-Ca; Ca; Tryptophan; Evocalcet; Etelcalcetide; PO4
11.54Single7T94LY21196207T94-M2-Acetylcholine-LY2119620-chim(NtGi1-Go)/β1/γ2
11.54Single7VV6C48/807VV6-MRGPRX2-C48/80
11.54Single8HJ5PubChem 1390305318HJ5-MRGPRX1-PubChem 139030531-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single8K2WAMG4878K2W-CXCR3-AMG487
11.54Single8YRGFospropofol8YRG-MRGPRX4-Fospropofol-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single8ZPMAMD0708ZPM-CXCR4-AMD070
11.54Single9IXXLTD49IXX-CysLT2-LTD4-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single9K0KUTP9K0K-P2Y4-UTP-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single9K0XATP9K0X-P2Y2-ATP-chim(NtGi1-Gs-CtGq)/β1/γ2
11.54Single9K20ATP9K20-P2Y2-ATP-chim(NtGi1-Go)/β1/γ2
11.54Consensuscxcr3_offOrthosteric Ligand8K2W-CXCR3-AMG487
11.43Single8HA0PTH8HA0-PTH1-PTH-chim(NtGi1-Gs)/β1/γ2
11.43Single9BLCCagrilintide backbone (non-acylated)9BLC-CT-Cagrilintide backbone (non-acylated)-Gs/β1/γ2
11.43Single9BUDCagrilintide9BUD-CT-Cagrilintide-Gs/β1/γ2
11.43Consensusneuromedin-u_onOrthosteric Ligandnmur1_on nmur2_on
11.36Consensusgluc_on_gpOrthosteric Ligand6LMK-Glucagon-Glucagon-Gs/β1/γ2 8JIT-Glucagon-MEDI0382-Gs/β1/γ2 7V35-Glucagon-Peptide-20-Gs/β1/γ2
11.11Single5T04Neurotensin5T04-NTS1-Neurotensin
11.11Single6D27CAY104716D27-DP2-CAY10471
11.11Single6X1ADanuglipron6X1A-GLP-1-Danuglipron-Gs/β1/γ2
11.11Single7LCIDanuglipron7LCI-GLP-1-Danuglipron-Gs/β1/γ2
11.11Single7LCKDanuglipron7LCK-GLP-1-Danuglipron
11.11Single7S15PubChem 1346112237S15-GLP-1-PubChem 134611223
11.11Single7TYHCalcitonin-17TYH-CT (AMY2)-Calcitonin-1-Gs/β1/γ2; RAMP2
11.11Single7Y35Abaloparatide7Y35-PTH1-Abaloparatide-Gs/β1/γ2
11.11Single8IC0Interleukin-88IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
11.11Single8ZYYNeurotensin peptide 8-138ZYY-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
11.11Consensuscxcr1_on_gpOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
10.71Single6LFMInterleukin-86LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
10.71Single6Z4SSR486926Z4S-NTS1-SR48692
10.71Single8JGGBAM8-228JGG-MRGPRX1-BAM8-22-Gi1/β1/γ2
10.71Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
10.71Single8T6JCDPPB8T6J-mGlu5; mGlu5-CDPPB
10.71Single8XQPCholesterol8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
10.71Consensuscxcr2_on_gpOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
10.53Consensusglp2_onOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
10.53Consensusglp2_on_gpOrthosteric Ligand7D68-GLP-2-GLP-2-Gs/β1/γ2
10.34Single6OS1TRV0266OS1-AT1-TRV026
10.34Single7XJLSpexin7XJL-GAL2-Spexin-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.34Single8GDBPGE28GDB-EP4-PGE2-Gs/β1/γ2
10.34Single8JGFBAM8-228JGF-MRGPRX1-BAM8-22-chim(NtGi1-Gs-CtGq)/β1/γ2
10.26Single6LMKGlucagon6LMK-Glucagon-Glucagon-Gs/β1/γ2
10.26Single9BQ3Cagrilintide9BQ3-CT (AMY2)-Cagrilintide-Gs/β1/γ2; RAMP2
10.00Single6OS2TRV0266OS2-AT1-TRV026
10.00Single6YVRNTS8-136YVR-NTS1-NTS8-13
10.00Single8DWCProenkephalin-A8DWC-MRGPRX1-Proenkephalin-A-chim(NtGi2L-Gs-CtGq)/β1/γ2
10.00Single8JPCNeurotensin-(8-13)8JPC-NTS1-Neurotensin-(8-13)-SBI-553; GDP; Mg-Gq; GRK2
9.68Single6M1HMaxadilan6M1H-PAC1-Maxadilan-Gs/β1/γ2
9.68Single7CX4Evatanepag7CX4-EP2-Evatanepag-Gs/β1/γ2
9.68Single8FN0Neurotensin/Neuromedin-N8FN0-NTS1-Neurotensin/Neuromedin-N-SBI-553-chim(NtGi1-Go)/β1/γ2
9.68Single8XVUCXCL28XVU-CXCR2-CXCL2
9.68Single8XXHCXCL28XXH-CXCR2-CXCL2-Go/β1/γ2
9.68Single9JH5C16:0 Ceramide9JH5-CysLT2-C16:0 Ceramide-chim(NtGi1-Gs-CtGq)/β1/γ2
9.38Single8XQJJN2418XQJ-Apelin-JN241
9.30Single8JITMEDI03828JIT-Glucagon-MEDI0382-Gs/β1/γ2
9.09Single7CX3Taprenepag7CX3-EP2-Taprenepag-Gs/β1/γ2
9.09Single7XKEBeta-Hydroxyandrosterone7XKE-ADGRG2-β-Hydroxyandrosterone-chim(NtGi1-Gs)/β1/γ2
9.09Single8JIQPeptide-158JIQ-Glucagon-Peptide-15-Gs/β1/γ2
8.82Single7SK5CXCL127SK5-ACKR3-CXCL12
8.70Single7VDMSubstance-P7VDM-MRGPRX2-Substance-P-Gi1/β1/γ2
8.33Single6D32Cyclopamine6D32-SMO-Cyclopamine-Cyclopamine
8.33Single7V6APubChem 98642757V6A-M4-PubChem 9864275-Gi1/β1/γ2
8.00Single8YKDDehydroepiandrosterone8YKD-ADGRG2-Dehydroepiandrosterone-chim(NtGi1-Gs)/β1/γ2
7.89Single9BUBCagrilintide9BUB-CT-Cagrilintide-Gs/β1/γ2
7.69Single4BWBNeurotensin4BWB-NTS1-Neurotensin
7.69Single8H8JLodoxamide8H8J-GPR35-Lodoxamide-Ca-chim(NtGi1L-G13)/β1/γ2
7.69Single8XXXCXCL68XXX-CXCR2-CXCL6-Go/β1/γ2
7.69Single8YYWAlpha-ketoglutarate8YYW-Oxoglutarate-α-ketoglutarate-α-ketoglutarate-chim(Gi1-CtGq)/β1/γ2
7.69Consensuscxcr1_onOrthosteric Ligand8IC0-CXCR1-Interleukin-8-Gi1/β1/γ2
7.41Single6U1NLY21196206U1N-M2-LY2119620-Arrestin2
7.41Single6ZINSR486926ZIN-NTS1-SR48692
7.41Single7C2EPubChem 1490507997C2E-GLP-1-PubChem 149050799-Gs/β1/γ2
7.41Single8JD6VU03647708JD6-mGlu4; mGlu4-Phosphoserine-VU0364770-Gi3/β1/γ2
7.41Consensuscxcr2_onOrthosteric Ligand6LFM-CXCR2-Interleukin-8-Gi1/β1/γ2
7.14Single9IVGGLP-1 (Truncated)9IVG-GLP-1-GLP-1 (Truncated)-chim(NtGi1-Gs)/β1/γ2
6.90Single6Z4QSR142948A6Z4Q-NTS1-SR142948A
6.90Single8ZYTNeurotensin peptide 8-138ZYT-NTS1-Neurotensin peptide 8-13-SBI-553-Arrestin2
6.67Single7F1TMIP-1a7F1T-CCR5-MIP-1a
6.67Single8JD5JNJ-40411813; ADX881788JD5-mGlu2; mGlu4-Glutamate-JNJ-40411813; ADX88178-Gi1/β1/γ2
6.67Single8XX7CXCL58XX7-CXCR2-CXCL5-Go/β1/γ2
6.45Single8GTMBMK-C2038GTM-CRF1-BMK-C203
6.45Single8XQJJN2418XQJ-Apelin-JN241
6.45Single8XWACXCL18XWA-CXCR2-CXCL1
6.45Single8XWMCXCL68XWM-CXCR2-CXCL6
6.45Single8XWSCXCL58XWS-CXCR2-CXCL5
6.45Single8XX3CXCL38XX3-CXCR2-CXCL3-Go/β1/γ2
6.25Single8XWFCXCL38XWF-CXCR2-CXCL3
6.25Single8XWVCXCL18XWV-CXCR2-CXCL1-Go/β1/γ2
6.06Single6KNMJN241-96KNM-Apelin-JN241-9
5.88Single7VLACCL15(27-92)7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.88Consensusccr1_onOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.88Consensusccr1_on_gpOrthosteric Ligand7VLA-CCR1-CCL15(27-92)-Gi1/β1/γ2
5.00Consensusclass-b2_onOrthosteric Ligandadgrg_on adgrf_on adgrl_on adgre_on adgrd_on
5.00Consensusclass-b2_on_gpOrthosteric Ligandadgrg_on_gp adgrf_on_gp adgrl_on_gp adgre_on_gp adgrd_on_gp
4.76Single8TLMAnti-murine CCR8 antibody8TLM-CCR8-Anti-murine CCR8 antibody
4.55Single8JGBConorfamide-Tx28JGB-MRGPRX1-Conorfamide-Tx2-Gi1/β1/γ2
4.35Single7V68LY21196207V68-M4-Iperoxo-LY2119620-Gi1/β1/γ2
4.35Single7XKDBeta-Hydroxyandrosterone7XKD-ADGRG2-β-Hydroxyandrosterone-Gs/β1/γ2
4.35Single8HQMNPGLY8HQM-GPR132-NPGLY-Gi1/β1/γ2
4.35Single8HVINOX-6-78HVI-GPR132-NOX-6-7-Gi1/β1/γ2
4.35Single8X9S5alpha-DHT8X9S-ADGRD1-5α-DHT-chim(NtGi1-Gs)/β1/γ2
4.17Single6XBM5LWE6XBM-SMO-5LWE-Gi1/β1/γ2
4.17Single7Y14Beta-Alanine7Y14-MRGPRD-β-Alanine
4.17Single8U4QREGN7663-Fab8U4Q-CXCR4-REGN7663-Fab-Gi1/β1/γ2
4.17Single9IVMLSN33188399IVM-GLP-1-GLP-1 (Truncated)-LSN3318839-chim(NtGi1-Gs)/β2/γ2
4.17Consensusp2y_offOrthosteric Ligandp2y1_off
4.00Single4XNWMRS25004XNW-P2Y1-MRS2500
4.00Single6PWCNeurotensin6PWC-NTS1-Neurotensin-Arrestin2
4.00Single7Y12Beta-Alanine7Y12-MRGPRD-β-Alanine-Gi1/β1/γ2
4.00Single8J6QCompound 9n8J6Q-HCA2-β-Hydroxybutyrate-Compound 9n-Gi1/β1/γ2
4.00Single8JRVGlucagon8JRV-Glucagon-Glucagon-Arrestin2
4.00Single8XQPAristolochic acid A8XQP-TAS2R14-Cholesterol-Aristolochic acid A-Gt3/β1/γ1
4.00Consensusp2y1_offOrthosteric Ligand4XNW-P2Y1-MRS2500
3.85Single4O9RCyclopamine4O9R-SMO-Cyclopamine
3.85Single7UL2SR486927UL2-NTS1-SR48692-Na
3.85Single8HSCFab0468HSC-GPR20-Fab046-Gi1/β1/γ2
3.85Single8J6PCompound 9n8J6P-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
3.85Single8JHYCompound 9n8JHY-HCA2-Compound 9n-Gi1/β1/γ2
3.85Single8JIICompound 9n8JII-HCA2-Niacin-Compound 9n-Gi1/β1/γ2
3.85Single9E7RGB889E7R-PAR2-GB88-chim(NtGi1L-Gs-CtGq)/β1/γ2
3.85Consensusneurotensin_offOrthosteric Ligandnts1_off
3.85Consensusnts1_offOrthosteric Ligand7UL2-NTS1-SR48692-Na
3.70Single4K5YCP-3763954K5Y-CRF1-CP-376395
3.70Single4QINSAG1.54QIN-SMO-SAG1.5
3.70Single4XNVBPTU4XNV-P2Y1-BPTU
3.70Single6O3CSAG21k6O3C-SMO-SAG21k-Cholesterol
3.70Single6WWZCCL206WWZ-CCR6-CCL20-Go/β1/γ2
3.70Single7WV9ZCZ0117WV9-CB1-CP55940-ZCZ011-Gi2/β1/γ2
3.70Single8U4SREGN7663-Fab8U4S-CXCR4-REGN7663-Fab
3.70Single8U4TREGN7663-Fab8U4T-CXCR4-REGN7663-Fab
3.70Consensusccr6_onOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
3.70Consensusccr6_on_gpOrthosteric Ligand6WWZ-CCR6-CCL20-Go/β1/γ2
3.57Single6XBLSAG6XBL-SMO-SAG-Cholesterol-Gi1/β1/γ2
3.57Single7ZI0SAG7ZI0-SMO-SAG-Cholesterol
3.57Single8IYXYL-3658IYX-GPR34-YL-365
3.45Single4Z9GCP-3763954Z9G-CRF1-CP-376395
3.45Single7RBTLSN35566727RBT-GIP-Tirzepatide-LSN3556672-chim(NtGi1-Gs)/β1/γ2
3.45Single7SK8CXCL127SK8-ACKR3-CXCL12-CCX662
3.45Single8GTIBMK-C2058GTI-CRF1-BMK-C205
3.45Single8TH3AT118-H Nanobody8TH3-AT1-AT118-H Nanobody
3.45Single9IMATalquetamab9IMA-GPRC5D-Talquetamab
3.33Single8GTGBMK-I1528GTG-CRF1-BMK-I152
3.33Single8TH4AT118-L Nanobody8TH4-AT1-Losartan-AT118-L Nanobody
3.33Single9EAHNanobody AT2099EAH-AT1-Olmesartan-Nanobody AT209
3.23Single7SK7CXCL127SK7-ACKR3-CXCL12-CCX662

PDB Summary
PDB 9B54
Class A
SubFamily Lipid
Type Cannabinoid
SubType CB1
Species Homo Sapiens
Ligand A1AIW
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 2.86
Date 2025-03-05
D.O.I. doi.org/10.1038/s41586-025-08618-7
Net Summary
Imin 1.76
Number of Linked Nodes 808
Number of Links 969
Number of Hubs 153
Number of Links mediated by Hubs 583
Number of Communities 34
Number of Nodes involved in Communities 243
Number of Links involved in Communities 328
Path Summary
Number Of Nodes in MetaPath 88
Number Of Links MetaPath 87
Number of Shortest Paths 1243520
Length Of Smallest Path 3
Average Path Length 33.4063
Length of Longest Path 66
Minimum Path Strength 1.12
Average Path Strength 4.95953
Maximum Path Strength 24.52
Minimum Path Correlation 0.7
Average Path Correlation 0.982005
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.7027
Average % Of Corr. Nodes 40.5975
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 51.9552
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• G protein-coupled receptor-like   • Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
SCOP2Family Identifier• G protein-coupled receptor-like   • Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
Code_L_
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
Code_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds

PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>9B54_Chain_A
CTLSAEDKA AVERSKMID RNLREDGEK AAREVKLLL LGAGESGKS 
TIVKQMKTG IVETHFTFK DLHFKMFDV GGQRSERKK WIHCFEGVT 
AIIFCVALS DYDLMNRMH ESMKLFDSI CNNKWFTDT SIILFLNKK 
DLFEEKIKK SPLTICYPE YAGSNTYEE AAAYIQCQF EDLNKRKDT 
KEIYTHFTC ATDTKNVQF VFDAVTDVI IKNNLKDCG LF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>9B54_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>9B54_Chain_G
ASIAQARKL VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL 
TPVPASENP FRE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP21554
Sequence
>9B54_Chain_R
FMVLNPSQQ LAIAVLSLT LGTFTVLEN LLVLCVIRC RPSYHFIGS 
LAVADLLGS VIFVYSFID FHVFHRKDS RNVFLFKLG GVTASFTAS 
VGSLFLTAI DRYISIHRP LAYKRIVTR PKAVVAFCL MWTIAIVIA 
VLPLLDIFP HIDETYLMF WIGVTSVLL LFIVYAYMY ILWKAHSHA 
VRMIQRGTA RMDIRLAKT LVLILVVLI ICWGPLLAI MVYDVFGKM 
NKLIKTVFA FCSMLCLLN STVNPIIYA LRSKDLRHA FRSM


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7FEEALipidCannabinoidCB1Homo sapiensCP55940ZCZ011-2.72022-06-15doi.org/10.1038/s41589-022-01038-y
7WV9ALipidCannabinoidCB1Homo sapiensCP55940ZCZ011Gi2/β1/γ23.362022-06-15doi.org/10.1038/s41589-022-01038-y
7WV9 (No Gprot) ALipidCannabinoidCB1Homo sapiensCP55940ZCZ0113.362022-06-15doi.org/10.1038/s41589-022-01038-y
8IKHALipidCannabinoidCB1Homo sapiens-Q2LGi1/β1/γ13.32024-06-05doi.org/10.1073/pnas.2321532121
8IKH (No Gprot) ALipidCannabinoidCB1Homo sapiens-Q2L3.32024-06-05doi.org/10.1073/pnas.2321532121
8IKGALipidCannabinoidCB1Homo sapiens-Q2BGi1/β1/γ13.42024-06-05doi.org/10.1073/pnas.2321532121
8IKG (No Gprot) ALipidCannabinoidCB1Homo sapiens-Q2B3.42024-06-05doi.org/10.1073/pnas.2321532121
6KQIALipidCannabinoidCB1Homo sapiensCP55940Org27569-3.252019-10-23doi.org/10.1038/s41589-019-0387-2
8K8JALipidCannabinoidCB1Homo sapiensFenofibrate-chim(Gs-CtGq)/β1/γ22.882024-02-14doi.org/10.1002/advs.202306311
8K8J (No Gprot) ALipidCannabinoidCB1Homo sapiensFenofibrate-2.882024-02-14doi.org/10.1002/advs.202306311
5TGZALipidCannabinoidCB1Homo sapiensAM6538--2.82016-11-02doi.org/10.1016/j.cell.2016.10.004
6N4BALipidCannabinoidCB1Homo sapiensMDMB-Fubinaca-Gi1/β1/γ232019-01-30doi.org/10.1016/j.cell.2018.11.040
6N4B (No Gprot) ALipidCannabinoidCB1Homo sapiensMDMB-Fubinaca-32019-01-30doi.org/10.1016/j.cell.2018.11.040
6KPGALipidCannabinoidCB1Homo sapiensAM841-Gi1/β1/γ232020-02-12doi.org/10.1016/j.cell.2020.01.008
6KPG (No Gprot) ALipidCannabinoidCB1Homo sapiensAM841-32020-02-12doi.org/10.1016/j.cell.2020.01.008
7V3ZALipidCannabinoidCB1Homo sapiensCP55940--3.292021-11-24doi.org/10.1021/jacs.1c06847
5U09ALipidCannabinoidCB1Homo sapiensTaranabant--2.62016-12-07doi.org/10.1038/nature20613
5XR8ALipidCannabinoidCB1Homo sapiensAM841--2.952017-07-12doi.org/10.1038/nature23272
5XRAALipidCannabinoidCB1Homo sapiensAM11542--2.82017-07-12doi.org/10.1038/nature23272
8GHVALipidCannabinoidCB1Homo sapiensAMG315-Gi1/β1/γ22.82023-05-24doi.org/10.1038/s41467-023-37864-4
8GHV (No Gprot) ALipidCannabinoidCB1Homo sapiensAMG315-2.82023-05-24doi.org/10.1038/s41467-023-37864-4
9B9ZALipidCannabinoidCB1Homo sapiensA1AKO--3.32024-11-20doi.org/10.1038/s41467-024-54206-0
9BA0ALipidCannabinoidCB1Homo sapiensA1AKN--3.132024-11-20doi.org/10.1038/s41467-024-54206-0
9B9YALipidCannabinoidCB1Homo sapiens7DY--3.52024-11-20doi.org/10.1038/s41467-024-54206-0
9B54 (No Gprot) ALipidCannabinoidCB1Homo sapiensA1AIW-2.862025-03-05doi.org/10.1038/s41586-025-08618-7
9B65ALipidCannabinoidCB1Homo sapiensKCA-Gi1/β1/γ23.032025-03-05doi.org/10.1038/s41586-025-08618-7
9B65 (No Gprot) ALipidCannabinoidCB1Homo sapiensKCA-3.032025-03-05doi.org/10.1038/s41586-025-08618-7
8WRZALipidCannabinoidCB1Homo sapiensPubChem 102336704-Arrestin23.62024-02-28doi.org/10.1093/procel/pwad055
9ERXALipidCannabinoidCB1Homo sapiensD9-THC analog-Gi1/β1/γ22.92024-06-26doi.org/10.21203/rs.3.rs-4277209/v1
9ERX (No Gprot) ALipidCannabinoidCB1Homo sapiensD9-THC analog-2.92024-06-26doi.org/10.21203/rs.3.rs-4277209/v1
8WU1ALipidCannabinoidCB1Homo sapiensPubChem 119025665-Arrestin23.22024-03-20doi.org/10.1016/j.cell.2023.11.017
9DGIALipidCannabinoidCB1Homo sapiensZ8526711350--3.352025-04-30doi.org/10.1038/s41467-025-57136-7
9EGOALipidCannabinoidCB1Homo sapiensYVF-Gi1/β1/γ23.22025-04-30doi.org/10.1038/s41467-025-57136-7
9EGO (No Gprot) ALipidCannabinoidCB1Homo sapiensYVF-3.22025-04-30doi.org/10.1038/s41467-025-57136-7
8GAGALipidCannabinoidCB1Homo sapiensPubChem 170838490-Gi1/β1/γ23.32024-02-28To be published
8GAG (No Gprot) ALipidCannabinoidCB1Homo sapiensPubChem 170838490-3.32024-02-28To be published




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