psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F170	5.79	Yes	No	1	0	7
2	L:L:?1	R:R:S173	2.38	Yes	No	0	0	4
3	L:L:?1	R:R:F174	2.9	Yes	Yes	1	0	5
4	L:L:?1	R:R:F177	6.76	Yes	Yes	1	0	4
5	L:L:?1	R:R:H178	11.21	Yes	No	1	0	4
6	L:L:?1	R:R:L193	4.39	Yes	No	1	0	4
7	L:L:?1	R:R:T197	8.18	Yes	Yes	1	0	6
8	L:L:?1	R:R:F200	5.79	Yes	No	0	0	7
9	L:L:?1	R:R:I267	6.79	Yes	Yes	1	0	4
10	L:L:?1	R:R:F268	7.72	Yes	Yes	1	0	5
11	L:L:?1	R:R:W279	6.32	Yes	Yes	1	0	6
12	L:L:?1	R:R:L359	2.19	Yes	No	1	0	7
13	L:L:?1	R:R:M363	3.36	Yes	Yes	1	0	6
14	L:L:?1	R:R:K376	3.35	Yes	No	0	0	2
15	L:L:?1	R:R:S383	4.76	Yes	No	1	0	6
16	R:R:D104	R:R:I105	2.8	No	No	0	6	3
17	R:R:D104	R:R:E106	16.89	No	No	0	6	4
18	R:R:I105	R:R:M109	2.92	No	No	1	3	3
19	R:R:F177	R:R:I105	5.02	Yes	No	1	4	3
20	R:R:C107	R:R:F108	4.19	No	No	0	2	5
21	R:R:F108	R:R:P269	14.45	No	No	0	5	3
22	R:R:F177	R:R:M109	9.95	Yes	No	1	4	3
23	R:R:H181	R:R:M109	5.25	No	No	0	3	3
24	R:R:K373	R:R:V110	9.11	No	No	0	3	3
25	R:R:K376	R:R:V110	12.14	No	No	0	2	3
26	R:R:L111	R:R:Q115	5.32	No	No	1	4	2
27	R:R:I119	R:R:L111	4.28	Yes	No	1	5	4
28	R:R:F381	R:R:L111	2.44	No	No	1	4	4
29	R:R:F381	R:R:Q115	7.03	No	No	1	4	2
30	R:R:Q116	R:R:V179	4.3	No	No	0	4	4
31	R:R:F174	R:R:I119	3.77	Yes	Yes	1	5	5
32	R:R:F381	R:R:I119	2.51	No	Yes	1	4	5
33	R:R:L122	R:R:M384	5.65	No	No	0	5	5
34	R:R:F129	R:R:T125	2.59	No	No	0	4	4
35	R:R:G127	R:R:T130	3.64	No	No	0	6	7
36	R:R:F129	R:R:T128	2.59	No	No	0	4	5
37	R:R:S167	R:R:T130	7.99	No	No	0	7	7
38	R:R:T130	R:R:T391	9.42	No	Yes	0	7	7
39	R:R:L164	R:R:V131	2.98	No	No	0	7	6
40	R:R:E133	R:R:T391	5.64	No	Yes	0	8	7
41	R:R:E133	R:R:P394	7.86	No	No	0	8	9
42	R:R:A160	R:R:N134	4.69	No	No	0	9	9
43	R:R:D163	R:R:N134	4.04	Yes	No	0	9	9
44	R:R:N134	R:R:P394	6.52	No	No	0	9	9
45	R:R:A160	R:R:L138	4.73	No	No	0	9	7
46	R:R:L138	R:R:V161	2.98	No	No	0	7	6
47	R:R:C139	R:R:V140	3.42	No	Yes	0	4	8
48	R:R:L404	R:R:V140	2.98	Yes	Yes	0	8	8
49	R:R:F408	R:R:V140	2.62	No	Yes	0	7	8
50	R:R:I141	R:R:L147	7.14	No	Yes	2	7	9
51	R:R:I141	R:R:Y153	8.46	No	Yes	2	7	9
52	R:R:I141	R:R:L404	4.28	No	Yes	2	7	8
53	R:R:L147	R:R:S144	7.51	Yes	No	2	9	6
54	R:R:A407	R:R:S144	3.42	No	No	2	7	6
55	R:R:L147	R:R:Y153	5.86	Yes	Yes	2	9	9
56	R:R:A407	R:R:L147	3.15	No	Yes	2	7	9
57	R:R:H154	R:R:R148	2.26	No	No	0	3	8
58	R:R:C149	R:R:R150	2.79	No	Yes	0	7	5
59	R:R:P151	R:R:R150	5.76	No	Yes	0	5	5
60	R:R:R150	R:R:S152	5.27	Yes	No	2	5	8
61	R:R:R150	R:R:Y153	4.12	Yes	Yes	2	5	9
62	R:R:P151	R:R:R230	2.88	No	No	0	5	1
63	R:R:S152	R:R:Y153	5.09	No	Yes	2	8	9
64	R:R:S401	R:R:Y153	5.09	No	Yes	2	8	9
65	R:R:D403	R:R:Y153	3.45	No	Yes	2	6	9
66	R:R:L404	R:R:Y153	3.52	Yes	Yes	2	8	9
67	R:R:F155	R:R:L209	8.53	Yes	No	0	8	6
68	R:R:F155	R:R:T210	3.89	Yes	No	0	8	9
69	R:R:D213	R:R:F155	2.39	No	Yes	0	9	8
70	R:R:A233	R:R:F155	2.77	No	Yes	0	7	8
71	R:R:S158	R:R:S206	4.89	No	No	0	9	8
72	R:R:F237	R:R:S158	5.28	No	No	5	8	9
73	R:R:S158	R:R:W241	3.71	No	Yes	5	9	9
74	R:R:D163	R:R:L159	5.43	Yes	Yes	4	9	9
75	R:R:L159	R:R:S206	6.01	Yes	No	0	9	8
76	R:R:L159	R:R:L207	2.77	Yes	No	4	9	8
77	R:R:L159	R:R:N393	6.87	Yes	Yes	4	9	9
78	R:R:L165	R:R:V161	2.98	No	No	0	6	6
79	R:R:A162	R:R:W241	2.59	No	Yes	0	8	9
80	R:R:D163	R:R:S203	5.89	Yes	No	0	9	9
81	R:R:D163	R:R:S390	11.78	Yes	No	0	9	9
82	R:R:D163	R:R:N393	4.04	Yes	Yes	4	9	9
83	R:R:G166	R:R:S199	3.71	No	No	0	8	7
84	R:R:L387	R:R:S167	3	No	No	0	7	7
85	R:R:I169	R:R:V196	3.07	No	No	0	5	7
86	R:R:F170	R:R:F174	6.43	No	Yes	1	7	5
87	R:R:F170	R:R:S383	2.64	No	No	1	7	6
88	R:R:D176	R:R:Y172	19.54	No	No	0	3	7
89	R:R:K192	R:R:Y172	2.39	Yes	No	0	6	7
90	R:R:K192	R:R:S173	4.59	Yes	No	0	6	4
91	R:R:F174	R:R:H178	10.18	Yes	No	1	5	4
92	R:R:D176	R:R:I175	2.8	No	No	0	3	5
93	R:R:I175	R:R:V179	4.61	No	No	0	5	4
94	R:R:F177	R:R:H178	9.05	Yes	No	1	4	4
95	R:R:F177	R:R:F189	2.14	Yes	No	0	4	9
96	R:R:F180	R:R:R182	10.69	No	No	0	4	4
97	R:R:D184	R:R:V188	4.38	No	No	0	2	5
98	R:R:R186	R:R:S185	2.64	No	No	0	3	7
99	R:R:N187	R:R:R186	6.03	No	No	0	1	3
100	R:R:H270	R:R:R186	3.39	No	No	0	3	3
101	R:R:F189	R:R:P269	7.22	No	No	0	9	3
102	R:R:L190	R:R:P251	6.57	No	No	0	5	6
103	R:R:L190	R:R:L252	8.3	No	No	0	5	5
104	R:R:L190	R:R:N256	4.12	No	No	0	5	6
105	R:R:F268	R:R:L193	4.87	Yes	No	1	5	4
106	R:R:I271	R:R:L193	2.85	No	No	1	3	4
107	R:R:G194	R:R:T197	3.64	No	Yes	0	6	6
108	R:R:F200	R:R:V196	2.62	No	No	0	7	7
109	R:R:T197	R:R:Y275	3.75	Yes	No	0	6	7
110	R:R:T197	R:R:W279	2.43	Yes	Yes	1	6	6
111	R:R:C386	R:R:F200	5.59	No	No	0	7	7
112	R:R:A244	R:R:T201	3.36	No	No	0	8	6
113	R:R:T201	R:R:W279	2.43	No	Yes	0	6	6
114	R:R:A202	R:R:W241	7.78	No	Yes	0	7	9
115	R:R:L286	R:R:V204	2.98	No	No	0	8	7
116	R:R:G205	R:R:M240	5.24	No	No	0	5	6
117	R:R:L207	R:R:N393	2.75	No	Yes	4	8	9
118	R:R:L207	R:R:Y397	4.69	No	No	0	8	9
119	R:R:F208	R:R:I212	7.54	Yes	No	0	7	7
120	R:R:F208	R:R:L286	7.31	Yes	No	0	7	8
121	R:R:F208	R:R:F289	6.43	Yes	No	0	7	6
122	R:R:F208	R:R:I290	5.02	Yes	No	0	7	8
123	R:R:R214	R:R:T210	3.88	No	No	0	9	9
124	R:R:A211	R:R:I290	3.25	No	No	0	8	8
125	R:R:D213	R:R:Y224	5.75	No	No	0	9	7
126	R:R:R214	R:R:Y294	5.14	No	Yes	0	9	9
127	R:R:R214	R:R:Y397	6.17	No	No	0	9	9
128	R:R:H219	R:R:Y215	11.98	No	No	3	6	8
129	R:R:A293	R:R:Y215	4	No	No	0	7	8
130	R:R:Y215	R:R:Y296	15.89	No	Yes	3	8	4
131	R:R:S217	R:R:Y224	12.72	No	No	0	8	7
132	R:R:I218	R:R:K300	7.27	No	No	0	9	5
133	R:R:H219	R:R:Y296	6.53	No	Yes	3	6	4
134	R:R:A223	R:R:R220	2.77	No	No	0	5	5
135	R:R:K225	R:R:Y224	8.36	No	No	0	4	7
136	R:R:P231	R:R:T229	12.24	No	No	0	4	8
137	R:R:K232	R:R:T229	4.5	No	No	0	5	8
138	R:R:F237	R:R:W241	10.02	No	Yes	5	8	9
139	R:R:M240	R:R:W241	2.33	No	Yes	0	6	9
140	R:R:I247	R:R:Y275	2.42	No	No	0	5	7
141	R:R:F278	R:R:I247	5.02	No	No	0	6	5
142	R:R:L250	R:R:P251	3.28	No	No	0	5	6
143	R:R:P251	R:R:Y275	8.34	No	No	0	6	7
144	R:R:G254	R:R:W255	2.81	No	No	0	5	5
145	R:R:K259	R:R:N256	2.8	No	No	0	4	6
146	R:R:C257	R:R:S262	3.44	No	No	0	9	3
147	R:R:C257	R:R:C264	7.28	No	No	0	9	9
148	R:R:C264	R:R:E258	4.56	No	No	0	9	1
149	R:R:E258	R:R:H270	16	No	No	0	1	3
150	R:R:E273	R:R:V263	4.28	No	No	0	3	4
151	R:R:I267	R:R:S265	3.1	Yes	No	1	4	4
152	R:R:F268	R:R:S265	2.64	Yes	No	1	5	4
153	R:R:I271	R:R:S265	3.1	No	No	1	3	4
154	R:R:D266	R:R:E273	5.2	No	No	0	4	3
155	R:R:D266	R:R:D366	11.98	No	No	1	4	4
156	R:R:D266	R:R:M371	5.54	No	Yes	1	4	1
157	R:R:F268	R:R:I267	5.02	Yes	Yes	1	5	4
158	R:R:D366	R:R:I267	11.2	No	Yes	1	4	4
159	R:R:I267	R:R:M371	4.37	Yes	Yes	1	4	1
160	R:R:F379	R:R:I267	5.02	Yes	Yes	1	4	4
161	R:R:F268	R:R:I271	2.51	Yes	No	1	5	3
162	R:R:F268	R:R:L276	2.44	Yes	No	0	5	5
163	R:R:F268	R:R:F379	4.29	Yes	Yes	1	5	4
164	R:R:H270	R:R:P269	6.1	No	No	0	3	3
165	R:R:D272	R:R:T274	10.12	No	No	0	5	5
166	R:R:I280	R:R:L276	4.28	Yes	No	0	5	5
167	R:R:I280	R:R:W279	3.52	Yes	Yes	1	5	6
168	R:R:T283	R:R:W279	10.92	No	Yes	0	8	6
169	R:R:L360	R:R:W279	4.56	No	Yes	1	7	6
170	R:R:M363	R:R:W279	3.49	Yes	Yes	1	6	6
171	R:R:I280	R:R:L360	4.28	Yes	No	1	5	7
172	R:R:I280	R:R:M363	7.29	Yes	Yes	1	5	6
173	R:R:L287	R:R:T283	2.95	No	No	0	6	8
174	R:R:L287	R:R:L352	4.15	No	No	7	6	9
175	R:R:L287	R:R:W356	4.56	No	Yes	7	6	8
176	R:R:L349	R:R:V291	5.96	No	No	0	8	5
177	R:R:I297	R:R:Y294	2.42	Yes	Yes	6	9	9
178	R:R:L345	R:R:Y294	3.52	Yes	Yes	6	8	9
179	R:R:I348	R:R:Y294	8.46	No	Yes	0	8	9
180	R:R:L349	R:R:Y294	2.34	No	Yes	0	8	9
181	R:R:W299	R:R:Y296	5.79	No	Yes	3	3	4
182	R:R:K300	R:R:Y296	7.17	No	Yes	3	5	4
183	R:R:I297	R:R:L345	2.85	Yes	Yes	6	9	8
184	R:R:K300	R:R:W299	2.32	No	No	3	5	3
185	R:R:H302	R:R:V306	4.15	No	No	0	5	5
186	R:R:D338	R:R:H302	8.82	No	No	0	7	5
187	R:R:A305	R:R:D338	4.63	No	No	0	5	7
188	R:R:K343	R:R:R400	3.71	No	No	0	7	7
189	R:R:L345	R:R:T344	2.95	Yes	No	0	8	8
190	R:R:I396	R:R:L347	4.28	No	No	0	9	7
191	R:R:L347	R:R:R400	2.43	No	No	0	7	7
192	R:R:I348	R:R:I396	2.94	No	No	0	8	9
193	R:R:L352	R:R:W356	3.42	No	Yes	7	9	8
194	R:R:C355	R:R:N389	6.3	No	No	0	8	9
195	R:R:C386	R:R:W356	5.22	No	Yes	0	7	8
196	R:R:N389	R:R:W356	3.39	No	Yes	0	9	8
197	R:R:G357	R:R:P358	4.06	No	No	0	5	9
198	R:R:L359	R:R:M363	4.24	No	Yes	1	7	6
199	R:R:F379	R:R:L359	4.87	Yes	No	1	4	7
200	R:R:F379	R:R:I362	8.79	Yes	No	0	4	4
201	R:R:C382	R:R:I362	3.27	No	No	0	5	4
202	R:R:F379	R:R:M363	4.98	Yes	Yes	1	4	6
203	R:R:I375	R:R:Y365	6.04	No	No	0	3	4
204	R:R:D366	R:R:M371	2.77	No	Yes	1	4	1
205	R:R:K370	R:R:N372	13.99	No	No	0	1	1
206	R:R:I375	R:R:M371	2.92	No	Yes	0	3	1
207	R:R:K376	R:R:M371	5.76	No	Yes	0	2	1
208	R:R:I375	R:R:N372	5.66	No	No	0	3	1
209	R:R:F379	R:R:S383	3.96	Yes	No	1	4	6
210	R:R:N389	R:R:N393	12.26	No	Yes	0	9	9
211	R:R:I395	R:R:L399	2.85	No	No	0	6	5
212	R:R:I396	R:R:Y397	2.42	No	No	0	9	9
213	R:R:A398	R:R:L404	3.15	No	Yes	0	7	8
214	R:R:D403	R:R:S401	4.42	No	No	2	6	8
215	R:R:L404	R:R:S401	3	Yes	No	2	8	8
216	R:R:K402	R:R:R405	2.48	No	No	0	5	8
217	R:R:H406	R:R:K402	3.93	No	No	0	4	5
218	R:R:F408	R:R:R409	2.14	No	No	0	7	5
219	R:R:R405	R:R:R409	2.13	No	No	0	8	5
220	R:R:G194	R:R:G195	2.11	No	No	0	6	4
221	R:R:Y292	R:R:Y296	1.99	No	Yes	0	4	4
222	R:R:A160	R:R:G157	1.95	No	No	0	9	6
223	R:R:A248	R:R:G194	1.95	No	No	0	7	6
224	R:R:A198	R:R:G195	1.95	No	No	0	5	4
225	R:R:C382	R:R:P358	1.88	No	No	0	5	9
226	R:R:P151	R:R:V228	1.77	No	No	0	5	6
227	R:R:G166	R:R:L165	1.71	No	No	0	8	6
228	R:R:G254	R:R:L253	1.71	No	No	0	5	5
229	R:R:C355	R:R:V351	1.71	No	No	0	8	6
230	R:R:A398	R:R:V137	1.7	No	No	0	7	9
231	R:R:G254	R:R:N256	1.7	No	No	0	5	6
232	R:R:L385	R:R:P358	1.64	No	No	0	7	9
233	R:R:N112	R:R:P113	1.63	No	No	0	6	2
234	R:R:S167	R:R:V171	1.62	No	No	0	7	7
235	R:R:A198	R:R:I245	1.62	No	No	0	5	4
236	R:R:A223	R:R:I227	1.62	No	No	0	5	4
237	R:R:A305	R:R:M337	1.61	No	No	0	5	6
238	R:R:V346	R:R:V350	1.6	No	No	0	6	6
239	R:R:V351	R:R:V392	1.6	No	No	0	6	6
240	R:R:T377	R:R:V110	1.59	No	No	0	1	3
241	R:R:T283	R:R:V282	1.59	No	No	0	8	6
242	R:R:T377	R:R:V378	1.59	No	No	0	1	4
243	R:R:A118	R:R:L122	1.58	No	No	0	5	5
244	R:R:A236	R:R:L209	1.58	No	No	0	5	6
245	R:R:A342	R:R:L298	1.58	No	No	0	7	6
246	R:R:A301	R:R:L341	1.58	No	No	0	8	8
247	R:R:C257	R:R:D272	1.56	No	No	0	9	5
248	R:R:I119	R:R:S123	1.55	Yes	No	0	5	7
249	R:R:I156	R:R:V137	1.54	No	No	0	8	9
250	R:R:I216	R:R:V228	1.54	No	No	0	5	6
251	R:R:I245	R:R:V249	1.54	No	No	0	4	5
252	R:R:I353	R:R:V291	1.54	No	No	0	6	5
253	R:R:A301	R:R:D338	1.54	No	No	0	8	7
254	R:R:I354	R:R:V350	1.54	No	No	0	5	6
255	R:R:I395	R:R:V392	1.54	No	No	0	6	6
256	R:R:K192	R:R:V188	1.52	Yes	No	0	6	5
257	R:R:F208	R:R:G205	1.51	Yes	No	0	7	5
258	R:R:L360	R:R:S284	1.5	No	No	0	7	5
259	R:R:L122	R:R:V121	1.49	No	No	0	5	4
260	R:R:L136	R:R:V140	1.49	No	Yes	0	7	8
261	R:R:L276	R:R:V367	1.49	No	No	0	5	4
262	R:R:D213	R:R:S152	1.47	No	No	0	9	8
263	R:R:I212	R:R:I216	1.47	No	No	0	7	5
264	R:R:I218	R:R:I297	1.47	No	Yes	0	9	9
265	R:R:L239	R:R:T242	1.47	No	No	0	3	4
266	R:R:L388	R:R:T391	1.47	No	Yes	0	5	7
267	R:R:I227	R:R:K232	1.45	No	No	0	4	5
268	R:R:P221	R:R:R220	1.44	No	No	0	8	5
269	R:R:P231	R:R:R230	1.44	No	No	0	4	1
270	R:R:I297	R:R:L341	1.43	Yes	No	0	9	8
271	R:R:L126	R:R:M384	1.41	No	No	0	6	5
272	R:R:L126	R:R:L387	1.38	No	No	0	6	7
273	R:R:L298	R:R:L341	1.38	No	No	0	6	8
274	R:R:L298	R:R:L345	1.38	No	Yes	0	6	8
275	R:R:N112	R:R:Q115	1.32	No	No	0	6	2
276	R:R:R145	R:R:S146	1.32	No	No	0	6	5
277	R:R:H304	R:R:M337	1.31	No	No	0	7	6
278	R:R:F129	R:R:T391	1.3	No	Yes	0	4	7
279	L:L:?1	R:R:A380	1.25	Yes	No	0	0	4
280	R:R:F191	R:R:K192	1.24	No	Yes	0	5	6
281	R:R:M337	R:R:R340	1.24	No	No	0	6	7
282	R:R:D176	R:R:R182	1.19	No	No	0	3	4
283	R:R:D184	R:R:R182	1.19	No	No	0	2	4
284	R:R:F155	R:R:H154	1.13	Yes	No	0	8	3
285	R:R:R336	R:R:R340	1.07	No	No	0	4	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	5.19625	16	1	0
2	R:R:I119	3.0275	4	1	5
3	R:R:V140	2.6275	4	0	8
4	R:R:L147	5.915	4	2	9
5	R:R:R150	4.485	4	2	5
6	R:R:Y153	5.08429	7	2	9
7	R:R:F155	3.742	5	0	8
8	R:R:L159	5.27	4	4	9
9	R:R:D163	6.236	5	4	9
10	R:R:F174	5.82	4	1	5
11	R:R:F177	6.584	5	1	4
12	R:R:K192	2.435	4	0	6
13	R:R:T197	4.5	4	1	6
14	R:R:F208	5.562	5	0	7
15	R:R:W241	5.286	5	5	9
16	R:R:I267	5.91667	6	1	4
17	R:R:F268	4.21286	7	1	5
18	R:R:W279	4.81	7	1	6
19	R:R:I280	4.8425	4	1	5
20	R:R:Y294	4.376	5	6	9
21	R:R:Y296	7.474	5	3	4
22	R:R:I297	2.0425	4	6	9
23	R:R:L345	2.675	4	6	8
24	R:R:W356	4.1475	4	7	8
25	R:R:M363	4.672	5	1	6
26	R:R:M371	4.272	5	1	1
27	R:R:F379	5.31833	6	1	4
28	R:R:T391	4.4575	4	0	7
29	R:R:N393	6.48	4	4	9
30	R:R:L404	3.386	5	2	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F177	22.267	6.76	Yes	Yes	1	0	4
2	R:R:F177	R:R:F189	16.7441	2.14	Yes	No	0	4	9
3	R:R:F189	R:R:P269	15.7623	7.22	No	No	0	9	3
4	L:L:?1	R:R:K376	13.0008	3.35	Yes	No	0	0	2
5	L:L:?1	R:R:F174	12.8255	2.9	Yes	Yes	1	0	5
6	R:R:F174	R:R:I119	13.1454	3.77	Yes	Yes	1	5	5
7	L:L:?1	R:R:S173	16.1173	2.38	Yes	No	0	0	4
8	R:R:K192	R:R:S173	15.188	4.59	Yes	No	0	6	4
9	L:L:?1	R:R:F200	78.7543	5.79	Yes	No	0	0	7
10	R:R:C386	R:R:F200	78.7543	5.59	No	No	0	7	7
11	R:R:C386	R:R:W356	78.7148	5.22	No	Yes	0	7	8
12	R:R:N389	R:R:W356	100	3.39	No	Yes	0	9	8
13	R:R:N389	R:R:N393	98.6061	12.26	No	Yes	0	9	9
14	R:R:D163	R:R:N393	32.1513	4.04	Yes	Yes	4	9	9
15	R:R:D163	R:R:N134	39.4451	4.04	Yes	No	0	9	9
16	R:R:N134	R:R:P394	27.4174	6.52	No	No	0	9	9
17	R:R:E133	R:R:P394	25.8745	7.86	No	No	0	8	9
18	R:R:E133	R:R:T391	24.3228	5.64	No	Yes	0	8	7
19	R:R:T130	R:R:T391	16.4329	9.42	No	Yes	0	7	7
20	R:R:S167	R:R:T130	13.2156	7.99	No	No	0	7	7
21	R:R:A160	R:R:N134	11.5938	4.69	No	No	0	9	9
22	R:R:L207	R:R:N393	70.9126	2.75	No	Yes	4	8	9
23	R:R:L207	R:R:Y397	82.4713	4.69	No	No	0	8	9
24	R:R:R214	R:R:Y397	76.9177	6.17	No	No	0	9	9
25	R:R:R214	R:R:T210	51.2975	3.88	No	No	0	9	9
26	R:R:F155	R:R:T210	50.3024	3.89	Yes	No	0	8	9
27	R:R:D213	R:R:F155	44.2009	2.39	No	Yes	0	9	8
28	R:R:D213	R:R:S152	39.9404	1.47	No	No	0	9	8
29	R:R:S152	R:R:Y153	23.2752	5.09	No	Yes	2	8	9
30	R:R:L404	R:R:Y153	16.4592	3.52	Yes	Yes	2	8	9
31	R:R:L404	R:R:V140	11.4929	2.98	Yes	Yes	0	8	8
32	R:R:R150	R:R:S152	15.5913	5.27	Yes	No	2	5	8
33	R:R:P151	R:R:R150	15.2275	5.76	No	Yes	0	5	5
34	R:R:P151	R:R:R230	11.322	2.88	No	No	0	5	1
35	R:R:L159	R:R:N393	14.1711	6.87	Yes	Yes	4	9	9
36	R:R:L159	R:R:S206	18.1205	6.01	Yes	No	0	9	8
37	R:R:S158	R:R:S206	16.994	4.89	No	No	0	9	8
38	R:R:S158	R:R:W241	14.9557	3.71	No	Yes	5	9	9
39	R:R:H270	R:R:P269	12.4441	6.1	No	No	0	3	3
40	L:L:?1	R:R:T197	20.505	8.18	Yes	Yes	1	0	6
41	R:R:T197	R:R:Y275	21.0879	3.75	Yes	No	0	6	7
42	R:R:P251	R:R:Y275	16.0121	8.34	No	No	0	6	7
43	R:R:L190	R:R:P251	12.729	6.57	No	No	0	5	6
44	R:R:G194	R:R:T197	10.9363	3.64	No	Yes	0	6	6
45	R:R:M240	R:R:W241	12.4047	2.33	No	Yes	0	6	9
46	R:R:G205	R:R:M240	11.4535	5.24	No	No	0	5	6
47	R:R:F208	R:R:G205	10.5462	1.51	Yes	No	0	7	5
48	R:R:R214	R:R:Y294	35.3993	5.14	No	Yes	0	9	9
49	R:R:I297	R:R:Y294	25.8525	2.42	Yes	Yes	6	9	9
50	R:R:I218	R:R:I297	11.5368	1.47	No	Yes	0	9	9
51	R:R:I218	R:R:K300	10.1385	7.27	No	No	0	9	5
52	L:L:?1	R:R:I267	18.3352	6.79	Yes	Yes	1	0	4
53	R:R:T283	R:R:W279	21.6709	10.92	No	Yes	0	8	6
54	R:R:L287	R:R:T283	21.7936	2.95	No	No	0	6	8
55	R:R:I297	R:R:L341	14.0659	1.43	Yes	No	0	9	8
56	R:R:A301	R:R:L341	12.9657	1.58	No	No	0	8	8
57	R:R:A301	R:R:D338	11.5675	1.54	No	No	0	8	7
58	R:R:F379	R:R:I362	27.2596	8.79	Yes	No	0	4	4
59	R:R:C382	R:R:I362	21.8243	3.27	No	No	0	5	4
60	R:R:C382	R:R:P358	16.3803	1.88	No	No	0	5	9
61	R:R:T197	R:R:W279	12.4704	2.43	Yes	Yes	1	6	6
62	R:R:L287	R:R:W356	21.3378	4.56	No	Yes	7	6	8
63	R:R:L159	R:R:L207	12.3827	2.77	Yes	No	4	9	8
64	R:R:D163	R:R:L159	11.6551	5.43	Yes	Yes	4	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:F170	5.79	1	Yes	No	0	7	0	1
L:L:?1	R:R:S173	2.38	1	Yes	No	0	4	0	1
L:L:?1	R:R:F174	2.9	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:F177	6.76	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:H178	11.21	1	Yes	No	0	4	0	1
L:L:?1	R:R:L193	4.39	1	Yes	No	0	4	0	1
L:L:?1	R:R:T197	8.18	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F200	5.79	1	Yes	No	0	7	0	1
L:L:?1	R:R:I267	6.79	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:F268	7.72	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:W279	6.32	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:L359	2.19	1	Yes	No	0	7	0	1
L:L:?1	R:R:M363	3.36	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:K376	3.35	1	Yes	No	0	2	0	1
L:L:?1	R:R:S383	4.76	1	Yes	No	0	6	0	1
R:R:I105	R:R:M109	2.92	1	No	No	3	3	2	2
R:R:F177	R:R:I105	5.02	1	Yes	No	4	3	1	2
R:R:F177	R:R:M109	9.95	1	Yes	No	4	3	1	2
R:R:K376	R:R:V110	12.14	0	No	No	2	3	1	2
R:R:F174	R:R:I119	3.77	1	Yes	Yes	5	5	1	2
R:R:F170	R:R:F174	6.43	1	No	Yes	7	5	1	1
R:R:F170	R:R:S383	2.64	1	No	No	7	6	1	1
R:R:K192	R:R:S173	4.59	0	Yes	No	6	4	2	1
R:R:F174	R:R:H178	10.18	1	Yes	No	5	4	1	1
R:R:F177	R:R:H178	9.05	1	Yes	No	4	4	1	1
R:R:F177	R:R:F189	2.14	1	Yes	No	4	9	1	2
R:R:F268	R:R:L193	4.87	1	Yes	No	5	4	1	1
R:R:I271	R:R:L193	2.85	1	No	No	3	4	2	1
R:R:G194	R:R:T197	3.64	0	No	Yes	6	6	2	1
R:R:F200	R:R:V196	2.62	0	No	No	7	7	1	2
R:R:T197	R:R:Y275	3.75	1	Yes	No	6	7	1	2
R:R:T197	R:R:W279	2.43	1	Yes	Yes	6	6	1	1
R:R:C386	R:R:F200	5.59	0	No	No	7	7	2	1
R:R:T201	R:R:W279	2.43	0	No	Yes	6	6	2	1
R:R:I267	R:R:S265	3.1	1	Yes	No	4	4	1	2
R:R:F268	R:R:S265	2.64	1	Yes	No	5	4	1	2
R:R:I271	R:R:S265	3.1	1	No	No	3	4	2	2
R:R:F268	R:R:I267	5.02	1	Yes	Yes	5	4	1	1
R:R:D366	R:R:I267	11.2	1	No	Yes	4	4	2	1
R:R:I267	R:R:M371	4.37	1	Yes	Yes	4	1	1	2
R:R:F379	R:R:I267	5.02	1	Yes	Yes	4	4	2	1
R:R:F268	R:R:I271	2.51	1	Yes	No	5	3	1	2
R:R:F268	R:R:L276	2.44	1	Yes	No	5	5	1	2
R:R:F268	R:R:F379	4.29	1	Yes	Yes	5	4	1	2
R:R:I280	R:R:L276	4.28	1	Yes	No	5	5	2	2
R:R:I280	R:R:W279	3.52	1	Yes	Yes	5	6	2	1
R:R:T283	R:R:W279	10.92	0	No	Yes	8	6	2	1
R:R:L360	R:R:W279	4.56	1	No	Yes	7	6	2	1
R:R:M363	R:R:W279	3.49	1	Yes	Yes	6	6	1	1
R:R:I280	R:R:L360	4.28	1	Yes	No	5	7	2	2
R:R:I280	R:R:M363	7.29	1	Yes	Yes	5	6	2	1
R:R:L359	R:R:M363	4.24	1	No	Yes	7	6	1	1
R:R:F379	R:R:L359	4.87	1	Yes	No	4	7	2	1
R:R:F379	R:R:M363	4.98	1	Yes	Yes	4	6	2	1
R:R:D366	R:R:M371	2.77	1	No	Yes	4	1	2	2
R:R:K376	R:R:M371	5.76	0	No	Yes	2	1	1	2
R:R:F379	R:R:S383	3.96	1	Yes	No	4	6	2	1
L:L:?1	R:R:A380	1.25	1	Yes	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8GHV_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.14
Number of Linked Nodes	247
Number of Links	285
Number of Hubs	30
Number of Links mediated by Hubs	128
Number of Communities	7
Number of Nodes involved in Communities	55
Number of Links involved in Communities	84

Path Summary
Number Of Nodes in MetaPath	65
Number Of Links MetaPath	64
Number of Shortest Paths	42786
Length Of Smallest Path	3
Average Path Length	13.8465
Length of Longest Path	32
Minimum Path Strength	1.155
Average Path Strength	4.93812
Maximum Path Strength	12.1833
Minimum Path Correlation	0.7
Average Path Correlation	0.919963
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	45.6874
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	34.4624
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	ZI5
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	ZI5
Name	(5Z,8Z,11Z,13S,14Z)-N-[(2R)-1-hydroxypropan-2-yl]-13-methylicosa-5,8,11,14-tetraenamide
Synonyms
Identifier
Formula	C24 H41 N O2
Molecular Weight	375.588
SMILES
PubChem	145964903
Formal Charge	0
Total Atoms	68
Total Chiral Atoms	2
Total Bonds	67
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21554
Sequence	>8GHV_nogp_Chain_R D I E C F M V L N P S Q Q L A I A V L S L T L G T F T V L E N L L V L C V I L H S R S L R C R P S Y H F I G S L A V A D L L G S V I F V Y S F I D F H V F H R K D S R N V F L F K L G G V T A S F T A S V G S L F L T A I D R Y I S I H R P L A Y K R I V T R P K A V V A F C L M W T I A I V I A V L P L L G W N C E K L Q S V C S D I F P H I D E T Y L M F W I G V T S V L L L F I V Y A Y M Y I L W K A H S H A V R M D I R L A K T L V L I L V V L I I C W G P L L A I M V Y D V F G K M N K L I K T V F A F C S M L C L L N S T V N P I I Y A L R S K D L R H A F R S M F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7FEE	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	ZCZ011	-	2.7	2022-06-15	doi.org/10.1038/s41589-022-01038-y
	7WV9	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	ZCZ011	Gi2/β1/γ2	3.36	2022-06-15	doi.org/10.1038/s41589-022-01038-y
	7WV9 (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	ZCZ011		3.36	2022-06-15	doi.org/10.1038/s41589-022-01038-y
	8IKH	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	Q2L	Gi1/β1/γ1	3.3	2024-06-05	doi.org/10.1073/pnas.2321532121
	8IKH (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	Q2L		3.3	2024-06-05	doi.org/10.1073/pnas.2321532121
	8IKG	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	Q2B	Gi1/β1/γ1	3.4	2024-06-05	doi.org/10.1073/pnas.2321532121
	8IKG (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	Q2B		3.4	2024-06-05	doi.org/10.1073/pnas.2321532121
	6KQI	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	Org27569	-	3.25	2019-10-23	doi.org/10.1038/s41589-019-0387-2
	8K8J	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Fenofibrate	-	chim(Gs-CtGq)/β1/γ2	2.88	2024-02-14	doi.org/10.1002/advs.202306311
	8K8J (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Fenofibrate	-		2.88	2024-02-14	doi.org/10.1002/advs.202306311
	5TGZ	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM6538	-	-	2.8	2016-11-02	doi.org/10.1016/j.cell.2016.10.004
	6N4B	A	Lipid	Cannabinoid	CB₁	Homo sapiens	MDMB-Fubinaca	-	Gi1/β1/γ2	3	2019-01-30	doi.org/10.1016/j.cell.2018.11.040
	6N4B (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	MDMB-Fubinaca	-		3	2019-01-30	doi.org/10.1016/j.cell.2018.11.040
	6KPG	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM841	-	Gi1/β1/γ2	3	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	6KPG (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM841	-		3	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	7V3Z	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	-	-	3.29	2021-11-24	doi.org/10.1021/jacs.1c06847
	5U09	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Taranabant	-	-	2.6	2016-12-07	doi.org/10.1038/nature20613
	5XR8	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM841	-	-	2.95	2017-07-12	doi.org/10.1038/nature23272
	5XRA	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM11542	-	-	2.8	2017-07-12	doi.org/10.1038/nature23272
	8GHV	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AMG315	-	Gi1/β1/γ2	2.8	2023-05-24	doi.org/10.1038/s41467-023-37864-4
	8GHV (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AMG315	-		2.8	2023-05-24	doi.org/10.1038/s41467-023-37864-4
	9B9Z	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AKO	-	-	3.3	2024-11-20	doi.org/10.1038/s41467-024-54206-0
	9BA0	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AKN	-	-	3.13	2024-11-20	doi.org/10.1038/s41467-024-54206-0
	9B9Y	A	Lipid	Cannabinoid	CB₁	Homo sapiens	7DY	-	-	3.5	2024-11-20	doi.org/10.1038/s41467-024-54206-0
	9B54	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AIW	-	Gi1/β1/γ2	2.86	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	9B54 (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	A1AIW	-		2.86	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	9B65	A	Lipid	Cannabinoid	CB₁	Homo sapiens	KCA	-	Gi1/β1/γ2	3.03	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	9B65 (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	KCA	-		3.03	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	8WRZ	A	Lipid	Cannabinoid	CB₁	Homo sapiens	PubChem 102336704	-	Arrestin2	3.6	2024-02-28	doi.org/10.1093/procel/pwad055
	9ERX	A	Lipid	Cannabinoid	CB₁	Homo sapiens	D9-THC analog	-	Gi1/β1/γ2	2.9	2024-06-26	doi.org/10.21203/rs.3.rs-4277209/v1
	9ERX (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	D9-THC analog	-		2.9	2024-06-26	doi.org/10.21203/rs.3.rs-4277209/v1
	8WU1	A	Lipid	Cannabinoid	CB₁	Homo sapiens	PubChem 119025665	-	Arrestin2	3.2	2024-03-20	doi.org/10.1016/j.cell.2023.11.017
	9DGI	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Z8526711350	-	-	3.35	2025-04-30	doi.org/10.1038/s41467-025-57136-7
	9EGO	A	Lipid	Cannabinoid	CB₁	Homo sapiens	YVF	-	Gi1/β1/γ2	3.2	2025-04-30	doi.org/10.1038/s41467-025-57136-7
	9EGO (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	YVF	-		3.2	2025-04-30	doi.org/10.1038/s41467-025-57136-7
	8GAG	A	Lipid	Cannabinoid	CB₁	Homo sapiens	PubChem 170838490	-	Gi1/β1/γ2	3.3	2024-02-28	To be published
	8GAG (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	PubChem 170838490	-		3.3	2024-02-28	To be published

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