psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C107	R:R:E106	4.56	No	No	4	2	4
2	R:R:E106	R:R:K183	6.75	No	No	4	4	6
3	R:R:C107	R:R:K183	3.23	No	No	4	2	6
4	R:R:F108	R:R:P269	4.33	No	No	0	5	3
5	L:L:?1	R:R:F108	3.88	Yes	No	0	0	5
6	R:R:F177	R:R:M109	7.46	No	No	0	4	3
7	R:R:H181	R:R:M109	14.44	No	No	0	3	3
8	R:R:K376	R:R:V110	4.55	No	No	0	2	3
9	R:R:T377	R:R:V110	4.76	No	No	0	1	3
10	R:R:L111	R:R:Q115	3.99	No	No	0	4	2
11	R:R:L111	R:R:Q116	5.32	No	No	0	4	4
12	R:R:H178	R:R:L111	9	Yes	No	0	4	4
13	R:R:Q115	R:R:T377	4.25	No	No	0	2	1
14	R:R:F381	R:R:Q115	8.2	No	No	0	4	2
15	R:R:H181	R:R:Q116	8.65	No	No	0	3	4
16	R:R:F381	R:R:I119	8.79	No	No	5	4	5
17	R:R:I119	R:R:M384	5.83	No	Yes	5	5	5
18	R:R:L122	R:R:M384	4.24	No	Yes	0	5	5
19	R:R:M384	R:R:S123	4.6	Yes	No	0	5	7
20	R:R:L126	R:R:L387	5.54	No	Yes	0	6	7
21	R:R:L126	R:R:T391	5.9	No	No	0	6	7
22	R:R:G127	R:R:T130	3.64	No	Yes	0	6	7
23	R:R:N134	R:R:T130	4.39	Yes	Yes	0	9	7
24	R:R:S167	R:R:T130	7.99	No	Yes	0	7	7
25	R:R:L387	R:R:T130	2.95	Yes	Yes	0	7	7
26	R:R:S390	R:R:T130	3.2	No	Yes	0	9	7
27	R:R:T130	R:R:T391	4.71	Yes	No	0	7	7
28	R:R:L164	R:R:V131	2.98	No	No	0	7	6
29	R:R:E133	R:R:P394	11	No	No	0	8	9
30	R:R:E133	R:R:I395	4.1	No	No	0	8	6
31	R:R:D163	R:R:N134	6.73	Yes	Yes	0	9	9
32	R:R:N134	R:R:P394	6.52	Yes	No	0	9	9
33	R:R:P394	R:R:V137	3.53	No	No	0	9	9
34	R:R:A160	R:R:L138	3.15	No	No	0	9	7
35	R:R:L138	R:R:V161	2.98	No	No	0	7	6
36	R:R:L404	R:R:V140	4.47	Yes	No	0	8	8
37	R:R:I141	R:R:L147	4.28	No	Yes	3	7	9
38	R:R:I141	R:R:Y153	3.63	No	Yes	3	7	9
39	R:R:L142	R:R:R148	7.29	No	No	0	4	8
40	R:R:H143	R:R:S144	9.76	No	No	0	5	6
41	R:R:H143	R:R:M411	15.76	No	No	0	5	5
42	R:R:S144	R:R:S146	3.26	No	No	0	6	5
43	R:R:L147	R:R:S144	4.5	Yes	No	0	9	6
44	R:R:R145	R:R:R148	7.46	No	No	0	6	8
45	R:R:C149	R:R:R145	4.18	No	No	0	7	6
46	R:R:L147	R:R:Y153	8.21	Yes	Yes	3	9	9
47	R:R:D403	R:R:L147	5.43	No	Yes	0	6	9
48	R:R:L147	R:R:L404	4.15	Yes	Yes	3	9	8
49	R:R:A407	R:R:L147	3.15	No	Yes	0	7	9
50	R:R:R150	R:R:Y153	8.23	No	Yes	0	5	9
51	R:R:D403	R:R:R150	10.72	No	No	0	6	5
52	R:R:P151	R:R:V228	3.53	No	Yes	0	5	6
53	R:R:D213	R:R:S152	7.36	Yes	No	0	9	8
54	R:R:S401	R:R:Y153	7.63	No	Yes	3	8	9
55	R:R:L404	R:R:Y153	3.52	Yes	Yes	3	8	9
56	R:R:H154	R:R:R230	10.16	No	No	0	3	1
57	R:R:F155	R:R:L209	12.18	No	No	0	8	6
58	R:R:D213	R:R:F155	7.17	Yes	No	0	9	8
59	R:R:I156	R:R:Y397	3.63	No	Yes	0	8	9
60	R:R:S158	R:R:S206	3.26	No	No	0	9	8
61	R:R:F237	R:R:S158	6.61	No	No	7	8	9
62	R:R:S158	R:R:W241	4.94	No	Yes	7	9	9
63	R:R:D163	R:R:L159	8.14	Yes	Yes	2	9	9
64	R:R:L159	R:R:S203	3	Yes	No	2	9	9
65	R:R:L159	R:R:S206	7.51	Yes	No	0	9	8
66	R:R:L159	R:R:L207	5.54	Yes	No	2	9	8
67	R:R:L159	R:R:N393	6.87	Yes	Yes	2	9	9
68	R:R:L159	R:R:Y397	3.52	Yes	Yes	2	9	9
69	R:R:L165	R:R:V161	2.98	No	No	0	6	6
70	R:R:D163	R:R:S203	5.89	Yes	No	2	9	9
71	R:R:D163	R:R:S390	10.31	Yes	No	0	9	9
72	R:R:D163	R:R:N393	6.73	Yes	Yes	2	9	9
73	R:R:G166	R:R:S199	3.71	No	No	0	8	7
74	R:R:F200	R:R:G166	3.01	Yes	No	0	7	8
75	R:R:S167	R:R:V168	3.23	No	No	0	7	4
76	R:R:I169	R:R:V196	3.07	No	No	0	5	7
77	R:R:F170	R:R:F174	16.08	Yes	Yes	1	7	5
78	R:R:F170	R:R:V196	5.24	Yes	No	1	7	7
79	R:R:F170	R:R:F200	3.22	Yes	Yes	1	7	7
80	R:R:F170	R:R:S383	5.28	Yes	No	1	7	6
81	R:R:F170	R:R:L387	4.87	Yes	Yes	0	7	7
82	L:L:?1	R:R:F170	13.97	Yes	Yes	1	0	7
83	R:R:L387	R:R:V171	2.98	Yes	No	0	7	7
84	R:R:D176	R:R:Y172	3.45	No	No	0	3	7
85	R:R:K192	R:R:S173	12.24	Yes	No	0	6	4
86	R:R:F174	R:R:H178	9.05	Yes	Yes	1	5	4
87	L:L:?1	R:R:F174	8.54	Yes	Yes	1	0	5
88	R:R:I175	R:R:V179	3.07	No	No	0	5	4
89	R:R:D176	R:R:R182	14.29	No	No	0	3	4
90	R:R:F177	R:R:H178	3.39	No	Yes	1	4	4
91	L:L:?1	R:R:F177	13.19	Yes	No	1	0	4
92	L:L:?1	R:R:H178	4.1	Yes	Yes	1	0	4
93	R:R:F180	R:R:V179	10.49	No	No	0	4	4
94	R:R:D184	R:R:V188	5.84	No	No	0	2	5
95	R:R:D184	R:R:K192	4.15	No	Yes	0	2	6
96	R:R:S185	R:R:V188	4.85	No	No	0	7	5
97	R:R:N187	R:R:R186	12.05	No	No	0	1	3
98	R:R:E258	R:R:R186	23.26	No	No	0	1	3
99	R:R:H270	R:R:R186	4.51	No	No	0	3	3
100	R:R:F189	R:R:K192	6.2	Yes	Yes	0	9	6
101	R:R:F189	R:R:L193	3.65	Yes	No	1	9	4
102	R:R:F189	R:R:P269	4.33	Yes	No	0	9	3
103	R:R:F189	R:R:H270	9.05	Yes	No	0	9	3
104	L:L:?1	R:R:F189	3.1	Yes	Yes	1	0	9
105	R:R:L190	R:R:P251	3.28	No	No	0	5	6
106	R:R:L190	R:R:N256	4.12	No	No	0	5	6
107	R:R:F268	R:R:L193	7.31	Yes	No	1	5	4
108	L:L:?1	R:R:L193	6.17	Yes	No	1	0	4
109	L:L:?1	R:R:V196	7.59	Yes	No	1	0	7
110	R:R:T197	R:R:W279	8.49	No	Yes	1	6	6
111	L:L:?1	R:R:T197	3.76	Yes	No	1	0	6
112	R:R:C386	R:R:F200	9.78	No	Yes	0	7	7
113	L:L:?1	R:R:F200	3.1	Yes	Yes	1	0	7
114	R:R:A244	R:R:T201	3.36	No	No	0	8	6
115	R:R:T201	R:R:W279	6.06	No	Yes	0	6	6
116	R:R:A202	R:R:W241	11.67	No	Yes	0	7	9
117	R:R:L286	R:R:V204	4.47	No	No	0	8	7
118	R:R:V204	R:R:W356	4.9	No	No	0	7	8
119	R:R:G205	R:R:M240	3.49	No	No	0	5	6
120	R:R:L207	R:R:N393	4.12	No	Yes	2	8	9
121	R:R:L207	R:R:Y397	7.03	No	Yes	2	8	9
122	R:R:F208	R:R:I212	6.28	No	No	0	7	7
123	R:R:F208	R:R:L286	9.74	No	No	0	7	8
124	R:R:F208	R:R:F289	6.43	No	No	0	7	6
125	R:R:A236	R:R:L209	3.15	No	No	0	5	6
126	R:R:R214	R:R:T210	6.47	No	No	2	9	9
127	R:R:T210	R:R:Y397	3.75	No	Yes	2	9	9
128	R:R:A211	R:R:I290	4.87	No	No	0	8	8
129	R:R:A211	R:R:Y294	5.34	No	Yes	0	8	9
130	R:R:D213	R:R:Y224	9.2	Yes	Yes	6	9	7
131	R:R:D213	R:R:V228	8.76	Yes	Yes	6	9	6
132	R:R:R214	R:R:Y294	9.26	No	Yes	2	9	9
133	R:R:R214	R:R:Y397	6.17	No	Yes	2	9	9
134	R:R:H219	R:R:Y215	13.07	No	Yes	8	6	8
135	R:R:Y215	R:R:Y292	4.96	Yes	No	0	8	4
136	R:R:Y215	R:R:Y296	6.95	Yes	Yes	8	8	4
137	R:R:S217	R:R:Y224	6.36	No	Yes	0	8	7
138	R:R:I218	R:R:I297	5.89	No	No	0	9	9
139	R:R:I218	R:R:K300	2.91	No	No	0	9	5
140	R:R:H219	R:R:R220	16.93	No	No	0	6	5
141	R:R:H219	R:R:Y296	16.33	No	Yes	8	6	4
142	R:R:A223	R:R:I227	3.25	No	No	0	5	4
143	R:R:K225	R:R:Y224	3.58	No	Yes	0	4	7
144	R:R:V228	R:R:Y224	6.31	Yes	Yes	6	6	7
145	R:R:P231	R:R:T229	5.25	No	No	0	4	8
146	R:R:P231	R:R:R230	2.88	No	No	0	4	1
147	R:R:F237	R:R:W241	7.02	No	Yes	7	8	9
148	R:R:M240	R:R:W241	5.82	No	Yes	0	6	9
149	R:R:I247	R:R:Y275	3.63	No	Yes	0	5	7
150	R:R:F278	R:R:I247	3.77	No	No	0	6	5
151	R:R:L250	R:R:W255	19.36	No	Yes	0	5	5
152	R:R:I271	R:R:P251	3.39	No	No	1	3	6
153	R:R:P251	R:R:Y275	13.91	No	Yes	1	6	7
154	R:R:D272	R:R:W255	3.35	No	Yes	1	5	5
155	R:R:T274	R:R:W255	4.85	No	Yes	1	5	5
156	R:R:W255	R:R:Y275	5.79	Yes	Yes	1	5	7
157	R:R:F278	R:R:W255	5.01	No	Yes	0	6	5
158	R:R:E258	R:R:N256	11.83	No	No	0	1	6
159	R:R:C257	R:R:C264	7.28	No	No	0	9	9
160	R:R:E258	R:R:K259	4.05	No	No	0	1	4
161	R:R:E273	R:R:V263	8.56	No	No	0	3	4
162	R:R:I271	R:R:S265	3.1	No	No	0	3	4
163	R:R:E273	R:R:S265	2.87	No	No	0	3	4
164	R:R:L276	R:R:S265	4.5	No	No	0	5	4
165	R:R:D266	R:R:I267	4.2	No	Yes	1	4	4
166	R:R:D266	R:R:M371	9.7	No	Yes	1	4	1
167	R:R:D266	R:R:K376	4.15	No	No	1	4	2
168	R:R:F268	R:R:I267	7.54	Yes	Yes	1	5	4
169	R:R:D366	R:R:I267	11.2	No	Yes	0	4	4
170	R:R:F379	R:R:I267	13.82	Yes	Yes	1	4	4
171	R:R:F268	R:R:F379	4.29	Yes	Yes	1	5	4
172	L:L:?1	R:R:F268	20.95	Yes	Yes	1	0	5
173	R:R:I271	R:R:Y275	4.84	No	Yes	1	3	7
174	R:R:D272	R:R:T274	5.78	No	No	1	5	5
175	R:R:E273	R:R:V367	8.56	No	No	0	3	4
176	L:L:?1	R:R:Y275	2.99	Yes	Yes	1	0	7
177	R:R:M277	R:R:V367	3.04	No	No	0	4	4
178	R:R:F278	R:R:V282	3.93	No	No	0	6	6
179	R:R:T283	R:R:W279	8.49	No	Yes	0	8	6
180	R:R:M363	R:R:W279	4.65	No	Yes	0	6	6
181	L:L:?1	R:R:W279	13.79	Yes	Yes	1	0	6
182	R:R:I280	R:R:M363	5.83	No	No	0	5	6
183	R:R:I280	R:R:V364	3.07	No	No	0	5	6
184	R:R:L287	R:R:T283	2.95	No	No	0	6	8
185	R:R:L360	R:R:T283	4.42	No	No	0	7	8
186	R:R:L288	R:R:S284	3	No	No	0	4	5
187	R:R:F289	R:R:V285	3.93	No	No	0	6	6
188	R:R:L287	R:R:L352	4.15	No	No	0	6	9
189	R:R:L349	R:R:V291	2.98	No	No	0	8	5
190	R:R:L345	R:R:Y294	8.21	No	Yes	0	8	9
191	R:R:I348	R:R:Y294	6.04	No	Yes	2	8	9
192	R:R:L349	R:R:Y294	5.86	No	Yes	0	8	9
193	R:R:Y294	R:R:Y397	4.96	Yes	Yes	2	9	9
194	R:R:W299	R:R:Y296	6.75	No	Yes	0	3	4
195	R:R:K300	R:R:Y296	7.17	No	Yes	0	5	4
196	R:R:A342	R:R:L298	3.15	No	No	0	7	6
197	R:R:A301	R:R:L341	4.73	No	No	0	8	8
198	R:R:H302	R:R:V306	5.54	No	No	0	5	5
199	R:R:D338	R:R:H302	3.78	Yes	No	0	7	5
200	R:R:H304	R:R:R307	3.39	No	No	0	7	4
201	R:R:H304	R:R:M308	10.51	No	No	0	7	7
202	R:R:H304	R:R:M337	6.57	No	No	0	7	6
203	R:R:A305	R:R:D338	4.63	No	Yes	0	5	7
204	R:R:Q310	R:R:V306	5.73	No	No	0	4	5
205	R:R:R307	R:R:R311	5.33	No	No	0	4	5
206	R:R:M308	R:R:T313	4.52	No	No	0	7	3
207	R:R:M308	R:R:Q314	6.8	No	No	0	7	3
208	R:R:A335	R:R:D338	3.09	No	Yes	0	4	7
209	R:R:D338	R:R:I339	4.2	Yes	No	0	7	5
210	R:R:R400	R:R:T344	6.47	No	No	0	7	8
211	R:R:I396	R:R:L347	5.71	No	No	0	9	7
212	R:R:L347	R:R:R400	3.64	No	No	0	7	7
213	R:R:I348	R:R:Y397	9.67	No	Yes	2	8	9
214	R:R:V351	R:R:V392	3.21	No	No	0	6	6
215	R:R:I396	R:R:V351	4.61	No	No	0	9	6
216	R:R:C355	R:R:L388	3.17	No	No	0	8	5
217	R:R:C355	R:R:N389	9.45	No	No	0	8	9
218	R:R:N389	R:R:W356	6.78	No	No	0	9	8
219	R:R:G357	R:R:P358	4.06	No	No	0	5	9
220	R:R:I362	R:R:I375	2.94	No	No	0	4	3
221	R:R:F379	R:R:I362	6.28	Yes	No	0	4	4
222	R:R:C382	R:R:I362	3.27	No	No	0	5	4
223	R:R:G369	R:R:Y365	2.9	No	No	0	3	4
224	R:R:K370	R:R:Y365	10.75	No	No	0	1	4
225	R:R:I375	R:R:Y365	9.67	No	No	0	3	4
226	R:R:D366	R:R:M371	6.93	No	Yes	0	4	1
227	R:R:K376	R:R:M371	2.88	No	Yes	1	2	1
228	L:L:?1	R:R:F379	6.21	Yes	Yes	1	0	4
229	R:R:F381	R:R:M384	3.73	No	Yes	5	4	5
230	R:R:C382	R:R:L385	3.17	No	No	0	5	7
231	L:L:?1	R:R:S383	9.57	Yes	No	1	0	6
232	R:R:N389	R:R:N393	12.26	No	Yes	0	9	9
233	R:R:I395	R:R:V392	3.07	No	No	0	6	6
234	R:R:I395	R:R:L399	4.28	No	No	0	6	5
235	R:R:I396	R:R:Y397	4.84	No	Yes	0	9	9
236	R:R:A398	R:R:L404	4.73	No	Yes	0	7	8
237	R:R:L404	R:R:S401	3	Yes	No	3	8	8
238	R:R:R405	R:R:R409	6.4	No	No	0	8	5
239	R:R:I141	R:R:L142	2.85	No	No	0	7	4
240	R:R:I212	R:R:L209	2.85	No	No	0	7	6
241	R:R:I297	R:R:L341	2.85	No	No	0	9	8
242	R:R:I297	R:R:L345	2.85	No	No	0	9	8
243	R:R:L359	R:R:M363	2.83	No	No	0	7	6
244	R:R:I375	R:R:N372	2.83	No	No	0	3	1
245	R:R:D213	R:R:I216	2.8	Yes	No	0	9	5
246	R:R:K373	R:R:N372	2.8	No	No	0	3	1
247	R:R:C238	R:R:F237	2.79	No	No	0	4	8
248	R:R:A233	R:R:F155	2.77	No	No	0	7	8
249	R:R:A380	R:R:F174	2.77	No	Yes	0	4	5
250	R:R:L190	R:R:L252	2.77	No	No	0	5	5
251	R:R:A223	R:R:R226	2.77	No	No	0	5	4
252	R:R:L298	R:R:L341	2.77	No	No	0	6	8
253	R:R:L164	R:R:N134	2.75	No	Yes	0	7	9
254	R:R:A293	R:R:Y215	2.67	No	Yes	0	7	8
255	R:R:F408	R:R:V140	2.62	No	No	0	7	8
256	R:R:A162	R:R:W241	2.59	No	Yes	0	8	9
257	R:R:F408	R:R:L399	2.44	No	No	0	7	5
258	R:R:F408	R:R:R405	2.14	No	No	0	7	8
259	R:R:G194	R:R:G195	2.11	No	No	0	6	4
260	R:R:A160	R:R:G157	1.95	No	No	0	9	6
261	R:R:A248	R:R:G194	1.95	No	No	0	7	6
262	R:R:A198	R:R:G195	1.95	No	No	0	5	4
263	R:R:G194	R:R:T197	1.82	No	No	0	6	6
264	R:R:G166	R:R:L165	1.71	No	No	0	8	6
265	R:R:G254	R:R:L253	1.71	No	No	0	5	5
266	R:R:G254	R:R:N256	1.7	No	No	0	5	6
267	R:R:C355	R:R:I354	1.64	No	No	0	8	5
268	R:R:L385	R:R:P358	1.64	No	No	0	7	9
269	R:R:N112	R:R:P113	1.63	No	No	0	6	2
270	R:R:C107	R:R:M109	1.62	No	No	0	2	3
271	R:R:A120	R:R:I175	1.62	No	No	0	5	5
272	R:R:C139	R:R:M411	1.62	No	No	0	4	5
273	R:R:A301	R:R:M337	1.61	No	No	0	8	6
274	R:R:C257	R:R:D272	1.56	No	No	0	9	5
275	R:R:I227	R:R:V228	1.54	No	Yes	0	4	6
276	R:R:I243	R:R:V246	1.54	No	No	0	5	3
277	R:R:A301	R:R:D338	1.54	No	Yes	0	8	7
278	R:R:I354	R:R:V350	1.54	No	No	0	5	6
279	R:R:K300	R:R:S303	1.53	No	No	0	5	5
280	R:R:M411	R:R:S410	1.53	No	No	0	5	3
281	R:R:K232	R:R:T229	1.5	No	No	0	5	8
282	R:R:G312	R:R:R311	1.5	No	No	0	4	5
283	R:R:L117	R:R:V121	1.49	No	No	0	5	4
284	R:R:L122	R:R:V121	1.49	No	No	0	5	4
285	R:R:L135	R:R:V131	1.49	No	No	0	3	6
286	R:R:L252	R:R:V249	1.49	No	No	0	5	5
287	R:R:I243	R:R:I247	1.47	No	No	0	5	5
288	R:R:L374	R:R:T377	1.47	No	No	0	4	1
289	R:R:P221	R:R:R220	1.44	No	No	0	8	5
290	R:R:Q116	R:R:V179	1.43	No	No	0	4	4
291	R:R:K259	R:R:L260	1.41	No	No	0	4	3
292	R:R:L298	R:R:M295	1.41	No	No	0	6	3
293	R:R:L349	R:R:M295	1.41	No	No	0	8	3
294	R:R:H154	R:R:V234	1.38	No	No	0	3	1
295	R:R:D176	R:R:K192	1.38	No	Yes	0	3	6
296	R:R:M103	R:R:Q261	1.36	No	No	0	4	1
297	R:R:F368	R:R:V364	1.31	No	No	0	5	6
298	R:R:F368	R:R:V367	1.31	No	No	0	5	4
299	R:R:F129	R:R:T391	1.3	No	No	0	4	7
300	R:R:F108	R:R:I105	1.26	No	No	0	5	3
301	R:R:I339	R:R:R336	1.25	No	No	0	5	4
302	R:R:F102	R:R:M371	1.24	No	Yes	0	5	1
303	R:R:I245	R:R:W241	1.17	No	Yes	0	4	9
304	R:R:H406	R:R:R409	1.13	No	No	0	4	5
305	R:R:R145	R:R:R230	1.07	No	No	0	6	1

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:T130	4.48	6	0	7
2	R:R:N134	5.0975	4	0	9
3	R:R:L147	4.95333	6	3	9
4	R:R:Y153	6.244	5	3	9
5	R:R:L159	5.76333	6	2	9
6	R:R:D163	7.56	5	2	9
7	R:R:F170	8.11	6	1	7
8	R:R:F174	9.11	4	1	5
9	R:R:H178	6.385	4	1	4
10	R:R:F189	5.266	5	1	9
11	R:R:K192	5.9925	4	0	6
12	R:R:F200	4.7775	4	1	7
13	R:R:D213	7.058	5	6	9
14	R:R:Y215	6.9125	4	8	8
15	R:R:Y224	6.3625	4	6	7
16	R:R:V228	5.035	4	6	6
17	R:R:W241	5.535	6	7	9
18	R:R:W255	7.672	5	1	5
19	R:R:I267	9.19	4	1	4
20	R:R:F268	10.0225	4	1	5
21	R:R:Y275	6.232	5	1	7
22	R:R:W279	8.296	5	1	6
23	R:R:Y294	6.61167	6	2	9
24	R:R:Y296	9.3	4	8	4
25	R:R:D338	3.448	5	0	7
26	R:R:M371	5.1875	4	1	1
27	R:R:F379	7.65	4	1	4
28	R:R:M384	4.6	4	5	5
29	R:R:L387	4.085	4	0	7
30	R:R:N393	7.495	4	2	9
31	R:R:Y397	5.44625	8	2	9
32	R:R:L404	3.974	5	3	8
33	L:L:?1	8.06067	15	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F189	14.8356	3.1	Yes	Yes	1	0	9
2	L:L:?1	R:R:F379	18.8611	6.21	Yes	Yes	1	0	4
3	R:R:H178	R:R:L111	26.7751	9	Yes	No	0	4	4
4	R:R:L111	R:R:Q115	17.6842	3.99	No	No	0	4	2
5	R:R:F381	R:R:Q115	11.4235	8.2	No	No	0	4	2
6	L:L:?1	R:R:F170	78.8142	13.97	Yes	Yes	1	0	7
7	R:R:F170	R:R:L387	100	4.87	Yes	Yes	0	7	7
8	R:R:L387	R:R:T130	99.8447	2.95	Yes	Yes	0	7	7
9	R:R:N134	R:R:T130	61.9382	4.39	Yes	Yes	0	9	7
10	R:R:S390	R:R:T130	40.0653	3.2	No	Yes	0	9	7
11	R:R:N134	R:R:P394	26.7146	6.52	Yes	No	0	9	9
12	R:R:E133	R:R:P394	25.6036	11	No	No	0	8	9
13	R:R:E133	R:R:I395	25.1665	4.1	No	No	0	8	6
14	R:R:D163	R:R:N134	45.9153	6.73	Yes	Yes	0	9	9
15	R:R:D163	R:R:S390	39.8784	10.31	Yes	No	0	9	9
16	R:R:I395	R:R:L399	30.4926	4.28	No	No	0	6	5
17	R:R:F408	R:R:L399	29.8713	2.44	No	No	0	7	5
18	R:R:F408	R:R:V140	27.3833	2.62	No	No	0	7	8
19	R:R:L404	R:R:V140	26.7356	4.47	Yes	No	0	8	8
20	R:R:L147	R:R:L404	14.9804	4.15	Yes	Yes	3	9	8
21	R:R:I141	R:R:L142	15.2963	2.85	No	No	0	7	4
22	R:R:L142	R:R:R148	13.7851	7.29	No	No	0	4	8
23	R:R:R145	R:R:R148	12.2686	7.46	No	No	0	6	8
24	R:R:D163	R:R:N393	28.8945	6.73	Yes	Yes	2	9	9
25	R:R:N389	R:R:N393	35.1025	12.26	No	Yes	0	9	9
26	R:R:N389	R:R:W356	28.8761	6.78	No	No	0	9	8
27	R:R:V204	R:R:W356	27.615	4.9	No	No	0	7	8
28	R:R:L286	R:R:V204	26.3486	4.47	No	No	0	8	7
29	R:R:F208	R:R:L286	25.077	9.74	No	No	0	7	8
30	R:R:F208	R:R:I212	21.2306	6.28	No	No	0	7	7
31	R:R:I212	R:R:L209	19.9379	2.85	No	No	0	7	6
32	R:R:F155	R:R:L209	17.3367	12.18	No	No	0	8	6
33	R:R:D213	R:R:F155	14.7066	7.17	Yes	No	0	9	8
34	R:R:D163	R:R:L159	54.9456	8.14	Yes	Yes	2	9	9
35	R:R:L159	R:R:Y397	49.5616	3.52	Yes	Yes	2	9	9
36	R:R:L159	R:R:S206	13.2665	7.51	Yes	No	0	9	8
37	R:R:S158	R:R:S206	11.9632	3.26	No	No	0	9	8
38	R:R:F174	R:R:H178	11.929	9.05	Yes	Yes	1	5	4
39	L:L:?1	R:R:Y275	25.5325	2.99	Yes	Yes	1	0	7
40	L:L:?1	R:R:W279	11.2866	13.79	Yes	Yes	1	0	6
41	R:R:Y294	R:R:Y397	46.9579	4.96	Yes	Yes	2	9	9
42	R:R:L345	R:R:Y294	37.938	8.21	No	Yes	0	8	9
43	R:R:I297	R:R:L345	36.7849	2.85	No	No	0	9	8
44	R:R:I218	R:R:I297	14.0984	5.89	No	No	0	9	9
45	R:R:I218	R:R:K300	12.9189	2.91	No	No	0	9	5
46	R:R:K300	R:R:Y296	10.3783	7.17	No	Yes	0	5	4
47	R:R:A301	R:R:L341	21.6518	4.73	No	No	0	8	8
48	R:R:I297	R:R:L341	22.7391	2.85	No	No	0	9	8
49	R:R:A301	R:R:D338	10.381	1.54	No	Yes	0	8	7
50	R:R:A301	R:R:M337	10.3757	1.61	No	No	0	8	6
51	R:R:I396	R:R:Y397	12.503	4.84	No	Yes	0	9	9
52	R:R:F379	R:R:I362	10.5968	6.28	Yes	No	0	4	4
53	L:L:?1	R:R:H178	16.1651	4.1	Yes	Yes	1	0	4
54	R:R:F170	R:R:F174	13.1243	16.08	Yes	Yes	1	7	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F108	R:R:P269	4.33	0	No	No	5	3	1	2
L:L:?1	R:R:F108	3.88	1	Yes	No	0	5	0	1
R:R:F177	R:R:M109	7.46	1	No	No	4	3	1	2
R:R:H178	R:R:L111	9	1	Yes	No	4	4	1	2
R:R:F200	R:R:G166	3.01	1	Yes	No	7	8	1	2
R:R:I169	R:R:V196	3.07	0	No	No	5	7	2	1
R:R:F170	R:R:F174	16.08	1	Yes	Yes	7	5	1	1
R:R:F170	R:R:V196	5.24	1	Yes	No	7	7	1	1
R:R:F170	R:R:F200	3.22	1	Yes	Yes	7	7	1	1
R:R:F170	R:R:S383	5.28	1	Yes	No	7	6	1	1
R:R:F170	R:R:L387	4.87	1	Yes	Yes	7	7	1	2
L:L:?1	R:R:F170	13.97	1	Yes	Yes	0	7	0	1
R:R:F174	R:R:H178	9.05	1	Yes	Yes	5	4	1	1
L:L:?1	R:R:F174	8.54	1	Yes	Yes	0	5	0	1
R:R:F177	R:R:H178	3.39	1	No	Yes	4	4	1	1
L:L:?1	R:R:F177	13.19	1	Yes	No	0	4	0	1
L:L:?1	R:R:H178	4.1	1	Yes	Yes	0	4	0	1
R:R:F189	R:R:K192	6.2	1	Yes	Yes	9	6	1	2
R:R:F189	R:R:L193	3.65	1	Yes	No	9	4	1	1
R:R:F189	R:R:P269	4.33	1	Yes	No	9	3	1	2
R:R:F189	R:R:H270	9.05	1	Yes	No	9	3	1	2
L:L:?1	R:R:F189	3.1	1	Yes	Yes	0	9	0	1
R:R:F268	R:R:L193	7.31	1	Yes	No	5	4	1	1
L:L:?1	R:R:L193	6.17	1	Yes	No	0	4	0	1
L:L:?1	R:R:V196	7.59	1	Yes	No	0	7	0	1
R:R:T197	R:R:W279	8.49	1	No	Yes	6	6	1	1
L:L:?1	R:R:T197	3.76	1	Yes	No	0	6	0	1
R:R:C386	R:R:F200	9.78	0	No	Yes	7	7	2	1
L:L:?1	R:R:F200	3.1	1	Yes	Yes	0	7	0	1
R:R:T201	R:R:W279	6.06	0	No	Yes	6	6	2	1
R:R:I247	R:R:Y275	3.63	0	No	Yes	5	7	2	1
R:R:I271	R:R:P251	3.39	1	No	No	3	6	2	2
R:R:P251	R:R:Y275	13.91	1	No	Yes	6	7	2	1
R:R:W255	R:R:Y275	5.79	1	Yes	Yes	5	7	2	1
R:R:F268	R:R:I267	7.54	1	Yes	Yes	5	4	1	2
R:R:F379	R:R:I267	13.82	1	Yes	Yes	4	4	1	2
R:R:F268	R:R:F379	4.29	1	Yes	Yes	5	4	1	1
L:L:?1	R:R:F268	20.95	1	Yes	Yes	0	5	0	1
R:R:I271	R:R:Y275	4.84	1	No	Yes	3	7	2	1
L:L:?1	R:R:Y275	2.99	1	Yes	Yes	0	7	0	1
R:R:T283	R:R:W279	8.49	0	No	Yes	8	6	2	1
R:R:M363	R:R:W279	4.65	0	No	Yes	6	6	2	1
L:L:?1	R:R:W279	13.79	1	Yes	Yes	0	6	0	1
R:R:F379	R:R:I362	6.28	1	Yes	No	4	4	1	2
L:L:?1	R:R:F379	6.21	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:S383	9.57	1	Yes	No	0	6	0	1
R:R:A380	R:R:F174	2.77	0	No	Yes	4	5	2	1
R:R:G194	R:R:T197	1.82	0	No	No	6	6	2	1
R:R:F108	R:R:I105	1.26	0	No	No	5	3	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9ERX_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.87
Number of Linked Nodes	268
Number of Links	305
Number of Hubs	33
Number of Links mediated by Hubs	135
Number of Communities	8
Number of Nodes involved in Communities	54
Number of Links involved in Communities	75

Path Summary
Number Of Nodes in MetaPath	55
Number Of Links MetaPath	54
Number of Shortest Paths	60866
Length Of Smallest Path	3
Average Path Length	14.3014
Length of Longest Path	32
Minimum Path Strength	1.31
Average Path Strength	5.91755
Maximum Path Strength	17.655
Minimum Path Correlation	0.7
Average Path Correlation	0.926636
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	48.0866
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.8448
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21554
Sequence	>9ERX_nogp_Chain_R E N F M D I E C F M V L N P S Q Q L A I A V L S L T L G T F T V L E N L L V L C V I L H S R S L R C R P S Y H F I G S L A V A D L L G S V I F V Y S F I D F H V F H R K D S R N V F L F K L G G V T A S F T A S V G S L F L T A I D R Y I S I H R P L A Y K R I V T R P K A V V A F C L M W T I A I V I A V L P L L G W N C E K L Q S V C S D I F P H I D E T Y L M F W I G V T S V L L L F I V Y A Y M Y I L W K A H S H A V R M I Q R G T Q K A R M D I R L A K T L V L I L V V L I I C W G P L L A I M V Y D V F G K M N K L I K T V F A F C S M L C L L N S T V N P I I Y A L R S K D L R H A F R S M F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	5TGZ	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM6538	-	-	2.8	2016-11-02	doi.org/10.1016/j.cell.2016.10.004
	5U09	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Taranabant	-	-	2.6	2016-12-07	doi.org/10.1038/nature20613
	5XR8	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM12033	-	-	2.95	2017-07-12	doi.org/10.1038/nature23272
	5XRA	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM11542	-	-	2.8	2017-07-12	doi.org/10.1038/nature23272
	6N4B	A	Lipid	Cannabinoid	CB₁	Homo sapiens	MDMB-Fubinaca	-	Gi1/β1/γ2	3	2019-01-30	doi.org/10.1016/j.cell.2018.11.040
	6N4B (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	MDMB-Fubinaca	-		3	2019-01-30	doi.org/10.1016/j.cell.2018.11.040
	6KQI	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	Org27569	-	3.25	2019-10-23	doi.org/10.1038/s41589-019-0387-2
	6KPG	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM841	-	Gi1/β1/γ2	3	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	6KPG (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM841	-		3	2020-02-12	doi.org/10.1016/j.cell.2020.01.008
	7V3Z	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	-	-	3.29	2021-11-24	doi.org/10.1021/jacs.1c06847
	7FEE	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	ZCZ011	-	2.7	2022-06-15	doi.org/10.1038/s41589-022-01038-y
	7WV9	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	ZCZ011	Gi2/β1/γ2	3.36	2022-06-15	doi.org/10.1038/s41589-022-01038-y
	7WV9 (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	CP55940	ZCZ011		3.36	2022-06-15	doi.org/10.1038/s41589-022-01038-y
	8GHV	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AMG315	-	Gi1/β1/γ2	2.8	2023-05-24	doi.org/10.1038/s41467-023-37864-4
	8GHV (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AMG315	-		2.8	2023-05-24	doi.org/10.1038/s41467-023-37864-4
	8IKG	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	PubChem 703205	Gi1/β1/γ1	3.4	2024-06-05	doi.org/10.1073/pnas.2321532121
	8IKG (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	PubChem 703205		3.4	2024-06-05	doi.org/10.1073/pnas.2321532121
	8IKH	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	PubChem 171393541	Gi1/β1/γ1	3.3	2024-06-05	doi.org/10.1073/pnas.2321532121
	8IKH (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	-	PubChem 171393541		3.3	2024-06-05	doi.org/10.1073/pnas.2321532121
	9ERX	A	Lipid	Cannabinoid	CB₁	Homo sapiens	D9-THC analog	-	Gi1/β1/γ2	2.9	2024-06-26	doi.org/10.21203/rs.3.rs-4277209/v1
	9ERX (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	D9-THC analog	-		2.9	2024-06-26	doi.org/10.21203/rs.3.rs-4277209/v1
	9B9Z	A	Lipid	Cannabinoid	CB₁	Homo sapiens	MRI-1867	-	-	3.3	2024-11-20	doi.org/10.1038/s41467-024-54206-0
	9BA0	A	Lipid	Cannabinoid	CB₁	Homo sapiens	MRI-1891	-	-	3.13	2024-11-20	doi.org/10.1038/s41467-024-54206-0
	9B54	A	Lipid	Cannabinoid	CB₁	Homo sapiens	VIP36	-	Gi1/β1/γ2	2.86	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	9B54 (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	VIP36	-		2.86	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	9B65	A	Lipid	Cannabinoid	CB₁	Homo sapiens	MDMB-Fubinaca	-	Gi1/β1/γ2	3.03	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	9B65 (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	MDMB-Fubinaca	-		3.03	2025-03-05	doi.org/10.1038/s41586-025-08618-7
	8K8J	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Fenofibrate	-	chim(Gs-CtGq)/β1/γ2	2.88	2024-02-14	doi.org/10.1002/advs.202306311
	8K8J (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Fenofibrate	-		2.88	2024-02-14	doi.org/10.1002/advs.202306311
	8GAG	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Z8526711350	-	Gi1/β1/γ2	3.3	2024-02-28	To be published
	8GAG (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Z8526711350	-		3.3	2024-02-28	To be published
	8WRZ	A	Lipid	Cannabinoid	CB₁	Homo sapiens	AM841	-	Arrestin2	3.6	2024-02-28	AM841
	8WU1	A	Lipid	Cannabinoid	CB₁	Homo sapiens	MDMB-Fubinaca	-	Arrestin2	3.2	2024-03-20	doi.org/10.1016/j.cell.2023.11.017
	9B9Y	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Taranabant	-	-	3.5	2024-11-20	doi.org/10.1038/s41467-024-54206-0
	9DGI	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Z8526711350	-	-	3.35	2025-04-30	doi.org/10.1038/s41467-025-57136-7
	9EGO	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Z8526711350	-	Gi1/β1/γ2	3.2	2025-04-30	doi.org/10.1038/s41467-025-57136-7
	9EGO (No Gprot)	A	Lipid	Cannabinoid	CB₁	Homo sapiens	Z8526711350	-		3.2	2025-04-30	doi.org/10.1038/s41467-025-57136-7

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9ERX_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.